SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.


HLH, helix-loop-helix DNA-binding domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   HLH-like [ 47458] (2)
Superfamily:   HLH, helix-loop-helix DNA-binding domain [ 47459]
Families:   HLH, helix-loop-helix DNA-binding domain [ 47460] (8)


Superfamily statistics
Genomes (466) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 26,209 65,201 13
Proteins 26,141 65,023 13


Functional annotation
General category coiled coil
Detailed category This is a complex coiled arrangement. The details of which will appear on this page shortly (some coiled coil details are being checked before they are included on the site). If you want to see examples of the states please click here here. If you require further details urgently please contact Owen Rackham

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.03205Least InformativeInherited
Disease Ontology (DO)nervous system cancer0.002076Moderately InformativeInherited
Disease Ontology (DO)disease of mental health0.1458Moderately InformativeInherited
Disease Ontology (DO)peripheral nervous system neoplasm0.01671InformativeInherited
Disease Ontology (DO)developmental disorder of mental health0.2782InformativeInherited
Disease Ontology (DO)autonomic nervous system neoplasm0.000001434Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Multifactorial inheritance0.0002871InformativeDirect
Mode of Inheritance (MI)Polygenic inheritance0.00004023Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of limbs0.264Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the head0.3825Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the skeletal system0.4585Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper limb0.08041Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the skull0.224Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limb bone morphology0.4683Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of finger0.05855InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the calvaria0.5454InformativeInherited
Phenotypic Abnormality (PA)Abnormality of calvarial morphology0.1826Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging0.000001992Least InformativeDirect
Mammalian Phenotype (MP)growth/size/body region phenotype0.00001323Least InformativeDirect
Mammalian Phenotype (MP)nervous system phenotype0.00002448Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0.002691Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.3473Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.6961Least InformativeInherited
Mammalian Phenotype (MP)lethality during fetal growth through weaning0.0001229Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal muscle morphology0.0001412Moderately InformativeDirect
Mammalian Phenotype (MP)embryo phenotype0.0004434Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal nervous system development0.000974Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal gland morphology0.00112Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.001267Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.009873Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.03898Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.05503Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.1185Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.1892Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.226Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.2696Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.4027Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.632Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.8073Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle physiology0.9644Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)normal phenotype0.00003972InformativeDirect
Mammalian Phenotype (MP)abnormal cell differentiation0.000191InformativeDirect
Mammalian Phenotype (MP)perinatal lethality0.0009258InformativeDirect
Mammalian Phenotype (MP)abnormal gas homeostasis0.009128InformativeInherited
Mammalian Phenotype (MP)abnormal neuron number0.01704InformativeInherited
Mammalian Phenotype (MP)abnormal coat appearance0.06077InformativeInherited
Mammalian Phenotype (MP)abnormal sensory neuron morphology0.09245InformativeInherited
Mammalian Phenotype (MP)abnormal brain development0.1008InformativeInherited
Mammalian Phenotype (MP)abnormal neuron physiology0.1305InformativeInherited
Mammalian Phenotype (MP)abnormal heart ventricle morphology0.1396InformativeInherited
Mammalian Phenotype (MP)abnormal respiratory function0.2161InformativeInherited
Mammalian Phenotype (MP)abnormal pancreas morphology0.393InformativeInherited
Mammalian Phenotype (MP)abnormal retinal neuronal layer morphology0.6393InformativeInherited
Mammalian Phenotype (MP)abnormal appendicular skeleton morphology0.8625InformativeInherited
Mammalian Phenotype (MP)increased sensory neuron number0.00003157Highly InformativeDirect
Mammalian Phenotype (MP)premature neuronal precursor differentiation0.0001013Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pancreatic acinus morphology0.0001579Highly InformativeDirect
Mammalian Phenotype (MP)abnormal breathing pattern0.0003421Highly InformativeDirect
Mammalian Phenotype (MP)thin retinal inner nuclear layer0.0003435Highly InformativeDirect
Mammalian Phenotype (MP)postnatal lethality0.0004987Highly InformativeDirect
Mammalian Phenotype (MP)cyanosis0.0005893Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating estradiol level0.0006632Highly InformativeDirect
Mammalian Phenotype (MP)abnormal skeletal muscle regeneration0.0007726Highly InformativeDirect
Mammalian Phenotype (MP)abnormal amacrine cell morphology0.0008714Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circadian rhythm0.001307Highly InformativeInherited
Mammalian Phenotype (MP)abnormal telencephalon development0.001593Highly InformativeInherited
Mammalian Phenotype (MP)abnormal brain ventricle morphology0.001929Highly InformativeInherited
Mammalian Phenotype (MP)abnormal CNS glial cell morphology0.00377Highly InformativeInherited
Mammalian Phenotype (MP)abnormal circumventricular organ morphology0.004559Highly InformativeInherited
Mammalian Phenotype (MP)decreased sensory neuron number0.05738Highly InformativeInherited
Mammalian Phenotype (MP)abnormal catecholamine level0.2298Highly InformativeInherited
Mammalian Phenotype (MP)abnormal coat/hair pigmentation0.2966Highly InformativeInherited
Mammalian Phenotype (MP)abnormal skeletal muscle fiber morphology0.4331Highly InformativeInherited
Mammalian Phenotype (MP)abnormal pituitary gland morphology0.6854Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell development variant0.000002518Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.000007279Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.0001458Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.0001478Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.001514Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.02369Least InformativeInherited
Worm Phenotype (WP)apoptosis variant0.002734Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.9155Moderately InformativeInherited
Worm Phenotype (WP)pattern of transgene expression variant1Moderately InformativeInherited
Worm Phenotype (WP)RNA expression variant0.0005007InformativeDirect
Worm Phenotype (WP)oxygen response variant0.009001InformativeInherited
Worm Phenotype (WP)positive chemotaxis variant0.2955InformativeInherited
Worm Phenotype (WP)organism pathogen response variant0.493InformativeInherited
Worm Phenotype (WP)neuronal cell fate specification variant0.000003018Highly InformativeDirect
Worm Phenotype (WP)ectopic expression transgene0.00007695Highly InformativeDirect
Worm Phenotype (WP)pathogen resistance increased0.0001221Highly InformativeDirect
Worm Phenotype (WP)aqueous positive chemotaxis defective0.0005226Highly InformativeDirect
Worm Phenotype (WP)nervous system physiology variant0.0005748Highly InformativeDirect
Worm Phenotype (WP)gene expression level reduced0.0006358Highly InformativeDirect
Worm Phenotype (WP)apoptosis reduced0.005348Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect
Yeast Phenotype (YP)metabolism and growth0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)behavior defective0.1945Moderately InformativeInherited
Fly Phenotype (FP)visible0.0000000001127InformativeDirect
Fly Phenotype (FP)circadian rhythm defective0.00796InformativeInherited
Fly Phenotype (FP)locomotor behavior defective0.6351InformativeInherited
Fly Phenotype (FP)locomotor rhythm defective0.000613Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)adult0.000001397Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0.0000593Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0.1111Least InformativeInherited
Fly Anatomy (FA)somatic cell0.2891Least InformativeInherited
Fly Anatomy (FA)nervous system0.3805Least InformativeInherited
Fly Anatomy (FA)larva0.5128Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)adult integumentary system0.01372Moderately InformativeInherited
Fly Anatomy (FA)appendage0.01768Moderately InformativeInherited
Fly Anatomy (FA)adult segment0.04962Moderately InformativeInherited
Fly Anatomy (FA)adult thorax0.05951Moderately InformativeInherited
Fly Anatomy (FA)neuron0.06332Moderately InformativeInherited
Fly Anatomy (FA)cell cluster organ0.1378Moderately InformativeInherited
Fly Anatomy (FA)thoracic segment0.1958Moderately InformativeInherited
Fly Anatomy (FA)tagmatic subdivision of integument0.2141Moderately InformativeInherited
Fly Anatomy (FA)ganglion0.2832Moderately InformativeInherited
Fly Anatomy (FA)sense organ0.3404Moderately InformativeInherited
Fly Anatomy (FA)somatic precursor cell0.3751Moderately InformativeInherited
Fly Anatomy (FA)late embryo0.4343Moderately InformativeInherited
Fly Anatomy (FA)portion of tissue0.5494Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.5553Moderately InformativeInherited
Fly Anatomy (FA)head1Moderately InformativeInherited
Fly Anatomy (FA)chaeta0.008364InformativeInherited
Fly Anatomy (FA)mechanosensory system0.00931InformativeInherited
Fly Anatomy (FA)interneuron0.0838InformativeInherited
Fly Anatomy (FA)adult procephalic segment0.1507InformativeInherited
Fly Anatomy (FA)neuromere0.195InformativeInherited
Fly Anatomy (FA)ventral nerve cord0.2104InformativeInherited
Fly Anatomy (FA)adult external head0.3091InformativeInherited
Fly Anatomy (FA)larval thoracic segment0.39InformativeInherited
Fly Anatomy (FA)leg0.4441InformativeInherited
Fly Anatomy (FA)sensory mother cell0.0001053Highly InformativeDirect
Fly Anatomy (FA)third segment of antenna0.000947Highly InformativeDirect
Fly Anatomy (FA)5-6I of thorax0.000947Highly InformativeDirect
Fly Anatomy (FA)head bristle0.02552Highly InformativeInherited
Fly Anatomy (FA)mechanosensory chaeta0.05833Highly InformativeInherited
Fly Anatomy (FA)segment of leg0.2357Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)portion of tissue0.01034Moderately InformativeInherited
Zebrafish Anatomy (ZA)cardiovascular system0.6126Moderately InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.000002893Least InformativeDirect
Xenopus ANatomical entity (XAN)tissue0.0002811Least InformativeDirect
Xenopus ANatomical entity (XAN)nervous system0.004742Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.019Least InformativeInherited
Xenopus ANatomical entity (XAN)cell0.1322Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.9405Least InformativeInherited
Xenopus ANatomical entity (XAN)trunk1Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)sensory system7.369e-16Moderately InformativeDirect
Xenopus ANatomical entity (XAN)embryonic structure0.000000000000005881Moderately InformativeDirect
Xenopus ANatomical entity (XAN)ectoderm0.009728Moderately InformativeInherited
Xenopus ANatomical entity (XAN)brain0.02004Moderately InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.1002Moderately InformativeInherited
Xenopus ANatomical entity (XAN)alimentary system1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)viscus1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)anatomical direction0InformativeDirect
Xenopus ANatomical entity (XAN)spinal cord0.000000000000001473InformativeDirect
Xenopus ANatomical entity (XAN)eye0.000000000000004413InformativeDirect
Xenopus ANatomical entity (XAN)neural plate0.000000000000184InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0.0000000000002638InformativeDirect
Xenopus ANatomical entity (XAN)anatomical space0.00000000001612InformativeDirect
Xenopus ANatomical entity (XAN)hindbrain0.00000000007352InformativeDirect
Xenopus ANatomical entity (XAN)pharyngeal region0.000000000891InformativeDirect
Xenopus ANatomical entity (XAN)epithelium0.000000004705InformativeDirect
Xenopus ANatomical entity (XAN)cranial placode0.000000007051InformativeDirect
Xenopus ANatomical entity (XAN)mesenchyme0.00000000734InformativeDirect
Xenopus ANatomical entity (XAN)forebrain0.00000001592InformativeDirect
Xenopus ANatomical entity (XAN)peripheral nervous system0.0000001565InformativeDirect
Xenopus ANatomical entity (XAN)cardiovascular system0.00000105InformativeDirect
Xenopus ANatomical entity (XAN)surface structure0.00006988InformativeDirect
Xenopus ANatomical entity (XAN)vestibuloauditory system0.01356InformativeInherited
Xenopus ANatomical entity (XAN)dermal system0.184InformativeInherited
Xenopus ANatomical entity (XAN)skeletal system0.2654InformativeInherited
Xenopus ANatomical entity (XAN)tail0.5792InformativeInherited
Xenopus ANatomical entity (XAN)skeletal muscle1InformativeInherited
Xenopus ANatomical entity (XAN)chordal neural plate0.0000000000009656Highly InformativeDirect
Xenopus ANatomical entity (XAN)proliferative region0.000000000002082Highly InformativeDirect
Xenopus ANatomical entity (XAN)neural plate border0.0000000005537Highly InformativeDirect
Xenopus ANatomical entity (XAN)neuron0.000000001215Highly InformativeDirect
Xenopus ANatomical entity (XAN)midbrain0.000000001364Highly InformativeDirect
Xenopus ANatomical entity (XAN)somite0.000000005825Highly InformativeDirect
Xenopus ANatomical entity (XAN)anterior neural fold0.0000000251Highly InformativeDirect
Xenopus ANatomical entity (XAN)intersomitic region0.00000002695Highly InformativeDirect
Xenopus ANatomical entity (XAN)non-neural ectoderm0.00000008457Highly InformativeDirect
Xenopus ANatomical entity (XAN)ganglion0.0000002205Highly InformativeDirect
Xenopus ANatomical entity (XAN)cranium0.0000003946Highly InformativeDirect
Xenopus ANatomical entity (XAN)tail tip0.0000005247Highly InformativeDirect
Xenopus ANatomical entity (XAN)anterior neural ridge0.000001119Highly InformativeDirect
Xenopus ANatomical entity (XAN)trunk musculature0.000003376Highly InformativeDirect
Xenopus ANatomical entity (XAN)circulatory system0.00001027Highly InformativeDirect
Xenopus ANatomical entity (XAN)neural groove0.00001426Highly InformativeDirect
Xenopus ANatomical entity (XAN)neural tube0.00001432Highly InformativeDirect
Xenopus ANatomical entity (XAN)intermediate mesoderm0.00001844Highly InformativeDirect
Xenopus ANatomical entity (XAN)blastema0.0000386Highly InformativeDirect
Xenopus ANatomical entity (XAN)foregut0.00006055Highly InformativeDirect
Xenopus ANatomical entity (XAN)presumptive midbrain-hindbrain boundary0.00006477Highly InformativeDirect
Xenopus ANatomical entity (XAN)optic field0.00008908Highly InformativeDirect
Xenopus ANatomical entity (XAN)retinal outer plexiform layer0.000117Highly InformativeDirect
Xenopus ANatomical entity (XAN)retinal ganglion cell layer0.0001239Highly InformativeDirect
Xenopus ANatomical entity (XAN)anatomical line0.0002466Highly InformativeDirect
Xenopus ANatomical entity (XAN)tail bud0.0003494Highly InformativeDirect
Xenopus ANatomical entity (XAN)involuted dorsal mesoderm0.0004937Highly InformativeDirect
Xenopus ANatomical entity (XAN)cranial nerve0.0006466Highly InformativeDirect
Xenopus ANatomical entity (XAN)primordium0.0007087Highly InformativeDirect
Xenopus ANatomical entity (XAN)ventral blood island0.002765Highly InformativeInherited
Xenopus ANatomical entity (XAN)cranial neural crest0.008781Highly InformativeInherited
Xenopus ANatomical entity (XAN)marginal zone1Highly InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)megasporophyll1Least InformativeInherited
Plant ANatomical entity (PAN)flower1Least InformativeInherited
Plant ANatomical entity (PAN)collective phyllome structure1Least InformativeInherited
Plant ANatomical entity (PAN)root system1Least InformativeInherited
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure1Least InformativeInherited
Plant ANatomical entity (PAN)root epidermis0.00003565InformativeDirect
Plant ANatomical entity (PAN)portion of ground tissue0.00313InformativeInherited
Plant ANatomical entity (PAN)primary root0.000356Highly InformativeDirect
Plant ANatomical entity (PAN)style0.001021Highly InformativeInherited

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect

Document: EC annotation of SCOP domains

InterPro annotation
Cross references IPR011598 SSF47459 Protein matches
Abstract

The helix-loop-helix (HLH) DNA-binding domain consists of a closed bundle of four helices in a left-handed twist with two crossover connections. The HLH domain directs dimerisation, and is juxtaposed to basic regions to create a DNA interaction interface surface that recognises specific DNA sequences. Basic region/HLH (bHLH) proteins regulate diverse biological pathways [PubMed10710415]. bHLH proteins include MyoD [PubMed12783965], SREBPs (sterol regulatory element binding proteins) [PubMed9634703], and yeast Pho4 (phosphatase system) [PubMed9303313].

In certain proteins the bHLH domain contains a leucine-zipper motif. The bHLH/leucine zipper (bHLHZip) domain specifies dimerisation within a network of proteins and determines sequence-specific DNA binding [PubMed10378692]. bHLHZip domains occur in the transcription factors Myc, Mad, Max and Usf [PubMed12553908, PubMed8306960].

This entry is bHLHZip, which covers the bHLH domain and the leucine zipper motif, when present.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 11 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a HLH, helix-loop-helix DNA-binding domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 11 hidden Markov models representing the HLH, helix-loop-helix DNA-binding domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]