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HLH, helix-loop-helix DNA-binding domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   HLH-like [ 47458] (2)
Superfamily:   HLH, helix-loop-helix DNA-binding domain [ 47459]
Families:   HLH, helix-loop-helix DNA-binding domain [ 47460] (8)


Superfamily statistics
Genomes (466) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 26,209 55,093 13
Proteins 26,141 54,947 13


Functional annotation
General category coiled coil
Detailed category This is a complex coiled arrangement. The details of which will appear on this page shortly (some coiled coil details are being checked before they are included on the site). If you want to see examples of the states please click here here. If you require further details urgently please contact Owen Rackham

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process00Least InformativeDirect
Biological Process (BP)biological regulation0.0000000001880Least InformativeDirect
Biological Process (BP)response to stimulus0.00051620Least InformativeDirect
Biological Process (BP)single-organism cellular process0.027380.0134Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.75371Least InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.000000000000052430Moderately InformativeDirect
Biological Process (BP)regulation of gene expression0.00000000000023660Moderately InformativeDirect
Biological Process (BP)regulation of cellular biosynthetic process0.00000000000028820Moderately InformativeDirect
Biological Process (BP)regulation of developmental process0.000000000096690.0000000008415Moderately InformativeDirect
Biological Process (BP)regulation of macromolecule biosynthetic process0.000016580Moderately InformativeDirect
Biological Process (BP)cellular response to stress0.00061620.04228Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.017790.00000000000008895Moderately InformativeInherited
Biological Process (BP)tissue development0.90920.0000007844Moderately InformativeInherited
Biological Process (BP)cell differentiation0.85770.1653Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.000010880.001461Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.035570Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.00033290.2964Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.10450.8785Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.6911Moderately InformativeInherited
Biological Process (BP)animal organ development0.11240.00001615Moderately InformativeInherited
Biological Process (BP)response to external stimulus0.53121Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.0023980.000000002566Moderately InformativeInherited
Biological Process (BP)response to radiation0.00000000019280.0001118InformativeDirect
Biological Process (BP)regulation of cell differentiation0.000000095370InformativeDirect
Biological Process (BP)negative regulation of multicellular organismal process0.000080260.0000001519InformativeDirect
Biological Process (BP)regulation of nervous system development0.000096750.00001897InformativeDirect
Biological Process (BP)regulation of cell proliferation0.000080320.7314InformativeInherited
Biological Process (BP)regulation of cell cycle0.0000075591InformativeInherited
Biological Process (BP)positive regulation of nucleobase-containing compound metabolic process0.0017960InformativeInherited
Biological Process (BP)generation of neurons00.001653InformativeInherited
Biological Process (BP)embryo development0.016290.0000002099InformativeInherited
Biological Process (BP)animal organ morphogenesis0.00019510.01775InformativeInherited
Biological Process (BP)system process0.15571InformativeInherited
Biological Process (BP)behavior0.000001650.001668InformativeInherited
Biological Process (BP)epithelium development0.045350.02199InformativeInherited
Biological Process (BP)central nervous system development0.024750.0119InformativeInherited
Biological Process (BP)post-embryonic development0.36091InformativeInherited
Biological Process (BP)cellular component morphogenesis0.2781InformativeInherited
Biological Process (BP)circadian rhythm0.000000000034950.000009225Highly InformativeDirect
Biological Process (BP)regulation of circadian rhythm0.00000000019310.0001126Highly InformativeDirect
Biological Process (BP)negative regulation of nervous system development0.0000086930.0000001231Highly InformativeDirect
Biological Process (BP)photoperiodism0.000083640.0000000000004991Highly InformativeDirect
Biological Process (BP)embryonic organ development0.00012130.000007473Highly InformativeDirect
Biological Process (BP)negative regulation of cell proliferation0.00031011Highly InformativeInherited
Biological Process (BP)aging0.0005250.8126Highly InformativeInherited
Biological Process (BP)positive regulation of cell cycle process0.000000000021810.09339Highly InformativeInherited
Biological Process (BP)tube morphogenesis0.00038760.01183Highly InformativeInherited
Biological Process (BP)epithelial cell differentiation0.0019060.001005Highly InformativeInherited
Biological Process (BP)negative regulation of cell development0.00020930.007435Highly InformativeInherited
Biological Process (BP)regulation of smooth muscle cell proliferation0.0000082660.00695Highly InformativeInherited
Biological Process (BP)regulation of blood pressure0.000000000000020640.01613Highly InformativeInherited
Biological Process (BP)locomotory behavior0.00000000027110.01553Highly InformativeInherited
Biological Process (BP)cell proliferation0.0000038650.007493Highly InformativeInherited
Biological Process (BP)response to red or far red light0.0077770.0001595Highly InformativeInherited
Molecular Function (MF)binding0.000046680Least InformativeDirect
Molecular Function (MF)nucleic acid binding0.023560Moderately InformativeInherited
Molecular Function (MF)transcription factor activity, sequence-specific DNA binding0.00000000000017120InformativeDirect
Molecular Function (MF)DNA binding0.00010030InformativeDirect
Molecular Function (MF)protein dimerization activity0.31730InformativeInherited
Molecular Function (MF)transcription factor binding0.0000092510Highly InformativeDirect
Molecular Function (MF)protein heterodimerization activity0.000070480Highly InformativeDirect
Cellular Component (CC)protein complex0.00093660Least InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle0.0012730Least InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.0134 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.7923 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.0000000008415 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 0.000000002566 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.00000000000008895 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0 Moderately Informative Direct
Biological Process (BP) animal organ development 0.00001615 Moderately Informative Direct
Biological Process (BP) tissue development 0.0000007844 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0.00000000000004085 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0.000000000003066 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0.0000000004207 Moderately Informative Direct
Biological Process (BP) reproduction 0.00000006293 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 0.0000002771 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 0.0000005076 Moderately Informative Direct
Biological Process (BP) gene expression 0.00003904 Moderately Informative Direct
Biological Process (BP) cell communication 0.00005791 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.1653 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) single-organism transport 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.1313 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.04228 Moderately Informative Inherited
Biological Process (BP) single organism signaling 0.7277 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.001461 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.8785 Moderately Informative Inherited
Biological Process (BP) immune system process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.2964 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.1597 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.0013 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to radiation 0.0001118 Informative Direct
Biological Process (BP) regulation of cell differentiation 0 Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.0000001519 Informative Direct
Biological Process (BP) regulation of nervous system development 0.00001897 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0 Informative Direct
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 0 Informative Direct
Biological Process (BP) positive regulation of gene expression 0 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0 Informative Direct
Biological Process (BP) response to organic cyclic compound 0 Informative Direct
Biological Process (BP) embryo development 0.0000002099 Informative Direct
Biological Process (BP) transcription, DNA-templated 0 Informative Direct
Biological Process (BP) cellular response to lipid 0.00001322 Informative Direct
Biological Process (BP) cell surface receptor signaling pathway 0.00004087 Informative Direct
Biological Process (BP) single organism reproductive process 0.0001022 Informative Direct
Biological Process (BP) regulation of proteolysis 0.0002175 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.000942 Informative Direct
Biological Process (BP) regulation of hydrolase activity 0.015 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 1 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 1 Informative Inherited
Biological Process (BP) negative regulation of cell death 0.4418 Informative Inherited
Biological Process (BP) regulation of catabolic process 1 Informative Inherited
Biological Process (BP) cellular component morphogenesis 1 Informative Inherited
Biological Process (BP) microtubule-based process 1 Informative Inherited
Biological Process (BP) regulation of secretion 0.0877 Informative Inherited
Biological Process (BP) regulation of peptide transport 0.02229 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.07616 Informative Inherited
Biological Process (BP) regulation of cell cycle 1 Informative Inherited
Biological Process (BP) epithelium development 0.02199 Informative Inherited
Biological Process (BP) circulatory system development 0.5229 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.01775 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.7314 Informative Inherited
Biological Process (BP) hemopoiesis 1 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) cell death 0.6843 Informative Inherited
Biological Process (BP) negative regulation of molecular function 1 Informative Inherited
Biological Process (BP) system process 1 Informative Inherited
Biological Process (BP) regulation of protein localization 0.2779 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.04708 Informative Inherited
Biological Process (BP) generation of neurons 0.001653 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) inorganic ion homeostasis 1 Informative Inherited
Biological Process (BP) cation homeostasis 1 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 0.129 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.0622 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.08125 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 1 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) positive regulation of immune system process 1 Informative Inherited
Biological Process (BP) behavior 0.001668 Informative Inherited
Biological Process (BP) response to oxidative stress 0.6699 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 1 Informative Inherited
Biological Process (BP) regulation of growth 1 Informative Inherited
Biological Process (BP) regulation of apoptotic process 1 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.9084 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 1 Informative Inherited
Biological Process (BP) regulation of phosphorylation 0.04471 Informative Inherited
Biological Process (BP) movement of cell or subcellular component 1 Informative Inherited
Biological Process (BP) single-organism cellular localization 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) regulation of protein modification process 0.2842 Informative Inherited
Biological Process (BP) response to acid chemical 0.4604 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.05321 Informative Inherited
Biological Process (BP) response to extracellular stimulus 0.001122 Informative Inherited
Biological Process (BP) supramolecular fiber organization 1 Informative Inherited
Biological Process (BP) cell activation 1 Informative Inherited
Biological Process (BP) phosphorylation 1 Informative Inherited
Biological Process (BP) intracellular transport 1 Informative Inherited
Biological Process (BP) organelle localization 1 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.7452 Informative Inherited
Biological Process (BP) response to temperature stimulus 1 Informative Inherited
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) cell development 1 Informative Inherited
Biological Process (BP) central nervous system development 0.0119 Informative Inherited
Biological Process (BP) regulation of cytokine production 1 Informative Inherited
Biological Process (BP) reproductive system development 0.02017 Informative Inherited
Biological Process (BP) post-embryonic development 1 Informative Inherited
Biological Process (BP) chromosome organization 0.006533 Informative Inherited
Biological Process (BP) negative regulation of cellular protein metabolic process 1 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) circadian rhythm 0.000009225 Highly Informative Direct
Biological Process (BP) regulation of circadian rhythm 0.0001126 Highly Informative Direct
Biological Process (BP) negative regulation of nervous system development 0.0000001231 Highly Informative Direct
Biological Process (BP) photoperiodism 0.0000000000004991 Highly Informative Direct
Biological Process (BP) embryonic organ development 0.000007473 Highly Informative Direct
Biological Process (BP) response to red or far red light 0.0001595 Highly Informative Direct
Biological Process (BP) positive regulation of nervous system development 0.00001993 Highly Informative Direct
Biological Process (BP) transition metal ion homeostasis 0 Highly Informative Direct
Biological Process (BP) response to hypoxia 0 Highly Informative Direct
Biological Process (BP) regulation of cysteine-type endopeptidase activity 0.0000000000001356 Highly Informative Direct
Biological Process (BP) regulation of fibroblast proliferation 0.000000000001244 Highly Informative Direct
Biological Process (BP) positive regulation of proteolysis 0.0000000003555 Highly Informative Direct
Biological Process (BP) MAPK cascade 0.00000002775 Highly Informative Direct
Biological Process (BP) regulation of chromosome organization 0.00000005492 Highly Informative Direct
Biological Process (BP) positive regulation of transcription from RNA polymerase II promoter 0.0000008104 Highly Informative Direct
Biological Process (BP) regulation of ATP metabolic process 0.00000186 Highly Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0.000002757 Highly Informative Direct
Biological Process (BP) regulation of cell division 0.000003853 Highly Informative Direct
Biological Process (BP) muscle organ development 0.000009653 Highly Informative Direct
Biological Process (BP) regulation of hormone secretion 0.00001002 Highly Informative Direct
Biological Process (BP) xenobiotic metabolic process 0.00001248 Highly Informative Direct
Biological Process (BP) regulation of hemopoiesis 0.00001607 Highly Informative Direct
Biological Process (BP) response to retinoic acid 0.00007613 Highly Informative Direct
Biological Process (BP) regulation of binding 0.0003058 Highly Informative Direct
Biological Process (BP) regulation of epithelial cell proliferation 0.0003588 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular signal transduction 0.0006179 Highly Informative Direct
Biological Process (BP) sex differentiation 0.0007024 Highly Informative Direct
Biological Process (BP) forebrain development 0.000859 Highly Informative Direct
Biological Process (BP) negative regulation of immune system process 0.01748 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 1 Highly Informative Inherited
Biological Process (BP) regulation of autophagy 0.1597 Highly Informative Inherited
Biological Process (BP) regulation of mitochondrion organization 0.3178 Highly Informative Inherited
Biological Process (BP) microtubule-based movement 0.4812 Highly Informative Inherited
Biological Process (BP) aging 0.8126 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.2392 Highly Informative Inherited
Biological Process (BP) kidney development 0.2025 Highly Informative Inherited
Biological Process (BP) angiogenesis 0.1514 Highly Informative Inherited
Biological Process (BP) response to growth factor 1 Highly Informative Inherited
Biological Process (BP) positive regulation of cell cycle process 0.09339 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.3363 Highly Informative Inherited
Biological Process (BP) cellular response to decreased oxygen levels 0.449 Highly Informative Inherited
Biological Process (BP) tube morphogenesis 0.01183 Highly Informative Inherited
Biological Process (BP) epithelial cell differentiation 0.001005 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 1 Highly Informative Inherited
Biological Process (BP) establishment of organelle localization 1 Highly Informative Inherited
Biological Process (BP) apoptotic process 0.02743 Highly Informative Inherited
Biological Process (BP) nervous system process 1 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 1 Highly Informative Inherited
Biological Process (BP) negative regulation of cell development 0.007435 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 1 Highly Informative Inherited
Biological Process (BP) plasma membrane bounded cell projection organization 0.0326 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 1 Highly Informative Inherited
Biological Process (BP) neuron development 0.9745 Highly Informative Inherited
Biological Process (BP) cell maturation 0.4477 Highly Informative Inherited
Biological Process (BP) positive regulation of cell development 0.1449 Highly Informative Inherited
Biological Process (BP) regulation of smooth muscle cell proliferation 0.00695 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular component biogenesis 1 Highly Informative Inherited
Biological Process (BP) positive regulation of nucleotide metabolic process 1 Highly Informative Inherited
Biological Process (BP) regulation of generation of precursor metabolites and energy 0.5623 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular catabolic process 1 Highly Informative Inherited
Biological Process (BP) regulation of blood pressure 0.01613 Highly Informative Inherited
Biological Process (BP) positive regulation of homeostatic process 1 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.01553 Highly Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter in response to stress 1 Highly Informative Inherited
Biological Process (BP) muscle system process 0.02786 Highly Informative Inherited
Biological Process (BP) regulation of response to wounding 0.433 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 1 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 1 Highly Informative Inherited
Biological Process (BP) positive regulation of apoptotic process 0.01782 Highly Informative Inherited
Biological Process (BP) carbohydrate homeostasis 0.1555 Highly Informative Inherited
Biological Process (BP) appendage development 0.476 Highly Informative Inherited
Biological Process (BP) camera-type eye development 0.06609 Highly Informative Inherited
Biological Process (BP) cell proliferation 0.007493 Highly Informative Inherited
Biological Process (BP) negative regulation of protein modification process 0.004744 Highly Informative Inherited
Biological Process (BP) negative regulation of phosphate metabolic process 0.07279 Highly Informative Inherited
Biological Process (BP) response to nutrient levels 0.02758 Highly Informative Inherited
Biological Process (BP) cellular response to extracellular stimulus 0.003103 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to growth factor stimulus 1 Highly Informative Inherited
Biological Process (BP) pigmentation 0.1045 Highly Informative Inherited
Biological Process (BP) extracellular matrix organization 0.4715 Highly Informative Inherited
Biological Process (BP) lymphocyte activation 0.2163 Highly Informative Inherited
Biological Process (BP) leukocyte differentiation 1 Highly Informative Inherited
Biological Process (BP) peptidyl-lysine modification 0.007839 Highly Informative Inherited
Biological Process (BP) histone modification 0.06706 Highly Informative Inherited
Biological Process (BP) cell-cell signaling 0.08003 Highly Informative Inherited
Biological Process (BP) striated muscle cell development 1 Highly Informative Inherited
Biological Process (BP) gliogenesis 0.2124 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 1 Highly Informative Inherited
Biological Process (BP) cellular response to abiotic stimulus 0.2781 Highly Informative Inherited
Biological Process (BP) response to carbohydrate 0.1646 Highly Informative Inherited
Biological Process (BP) heart development 0.01267 Highly Informative Inherited
Biological Process (BP) muscle tissue development 0.001039 Highly Informative Inherited
Biological Process (BP) gastrulation 0.981 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 1 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) nucleic acid binding 0 Moderately Informative Direct
Molecular Function (MF) transcription factor activity, sequence-specific DNA binding 0 Informative Direct
Molecular Function (MF) DNA binding 0 Informative Direct
Molecular Function (MF) protein dimerization activity 0 Informative Direct
Molecular Function (MF) enzyme binding 1 Informative Inherited
Molecular Function (MF) receptor binding 0.1574 Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 0.9374 Informative Inherited
Molecular Function (MF) signal transducer activity 0.07408 Informative Inherited
Molecular Function (MF) molecular transducer activity 0.3579 Informative Inherited
Molecular Function (MF) transcription factor binding 0 Highly Informative Direct
Molecular Function (MF) protein heterodimerization activity 0 Highly Informative Direct
Molecular Function (MF) chromatin binding 0.00000000000001306 Highly Informative Direct
Molecular Function (MF) acetyltransferase activity 0.09773 Highly Informative Inherited
Molecular Function (MF) double-stranded DNA binding 0.6128 Highly Informative Inherited
Molecular Function (MF) transcription factor activity, transcription factor binding 0.05754 Highly Informative Inherited
Molecular Function (MF) sequence-specific DNA binding 0.0288 Highly Informative Inherited
Molecular Function (MF) transcription regulatory region DNA binding 0.874 Highly Informative Inherited
Cellular Component (CC) protein complex 0 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) transferase complex 1 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.08298 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) nucleoplasm part 1 Informative Inherited
Cellular Component (CC) ribonucleoprotein granule 0.006915 Informative Inherited
Cellular Component (CC) chromosome 0.05147 Informative Inherited
Cellular Component (CC) receptor complex 0 Highly Informative Direct
Cellular Component (CC) RNA polymerase II transcription factor complex 0 Highly Informative Direct
Cellular Component (CC) chromatin 0.0000455 Highly Informative Direct
Cellular Component (CC) nuclear body 0.0008606 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation0Moderately InformativeDirect
Biological processDifferentiation0Moderately InformativeDirect
Biological processLipid metabolism1Moderately InformativeInherited
Biological processBiological rhythms0InformativeDirect
Biological processNeurogenesis0InformativeDirect
Biological processSteroid metabolism0.000000001779InformativeDirect
Biological processAngiogenesis0.00002143InformativeDirect
Biological processGrowth regulation0Highly InformativeDirect
Biological processMyogenesis0Highly InformativeDirect
Biological processNotch signaling pathway0Highly InformativeDirect
Biological processCholesterol metabolism0.00000000002791Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Coding sequence diversityChromosomal rearrangement0.000007654InformativeDirect
DiseaseProto-oncogene0Moderately InformativeDirect
DomainRepeat0.0002917Least InformativeDirect
Post-translational modificationRepressor0Moderately InformativeDirect
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationDNA-binding0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationAcetylation0.000002669Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationIsopeptide bond0Moderately InformativeDirect
Post-translational modificationHydroxylation0.0000000002946InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR011598 SSF47459 Protein matches
Abstract

The helix-loop-helix (HLH) DNA-binding domain consists of a closed bundle of four helices in a left-handed twist with two crossover connections. The HLH domain directs dimerisation, and is juxtaposed to basic regions to create a DNA interaction interface surface that recognises specific DNA sequences. Basic region/HLH (bHLH) proteins regulate diverse biological pathways [PubMed10710415]. bHLH proteins include MyoD [PubMed12783965], SREBPs (sterol regulatory element binding proteins) [PubMed9634703], and yeast Pho4 (phosphatase system) [PubMed9303313].

In certain proteins the bHLH domain contains a leucine-zipper motif. The bHLH/leucine zipper (bHLHZip) domain specifies dimerisation within a network of proteins and determines sequence-specific DNA binding [PubMed10378692]. bHLHZip domains occur in the transcription factors Myc, Mad, Max and Usf [PubMed12553908, PubMed8306960].

This entry is bHLHZip, which covers the bHLH domain and the leucine zipper motif, when present.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 10 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a HLH, helix-loop-helix DNA-binding domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 10 hidden Markov models representing the HLH, helix-loop-helix DNA-binding domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]