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HLH, helix-loop-helix DNA-binding domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   HLH-like [ 47458] (2)
Superfamily:   HLH, helix-loop-helix DNA-binding domain [ 47459]
Families:   HLH, helix-loop-helix DNA-binding domain [ 47460] (8)


Superfamily statistics
Genomes (466) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 26,209 65,201 13
Proteins 26,141 65,023 13


Functional annotation
General category coiled coil
Detailed category This is a complex coiled arrangement. The details of which will appear on this page shortly (some coiled coil details are being checked before they are included on the site). If you want to see examples of the states please click here here. If you require further details urgently please contact Owen Rackham

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.0319Least InformativeInherited
Disease Ontology (DO)nervous system cancer0.002062Moderately InformativeInherited
Disease Ontology (DO)disease of mental health0.1457Moderately InformativeInherited
Disease Ontology (DO)peripheral nervous system neoplasm0.01664InformativeInherited
Disease Ontology (DO)developmental disorder of mental health0.278InformativeInherited
Disease Ontology (DO)autonomic nervous system neoplasm0.000001415Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Polygenic inheritance0.00002679Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of limbs0.2739Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the skeletal system0.4746Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the head0.5139Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.8968Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper limb0.08834Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the skull0.1947Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limb bone morphology0.4879Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of central motor function0.9031Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the calvaria0.4941InformativeInherited
Phenotypic Abnormality (PA)Abnormality of phalanx of finger0.565InformativeInherited
Phenotypic Abnormality (PA)Paralysis0.04222Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of calvarial morphology0.1568Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the voice0.3291Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging0.000001977Least InformativeDirect
Mammalian Phenotype (MP)growth/size/body region phenotype0.00001315Least InformativeDirect
Mammalian Phenotype (MP)nervous system phenotype0.00002425Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0.0027Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.3476Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.6966Least InformativeInherited
Mammalian Phenotype (MP)lethality during fetal growth through weaning0.0001244Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal muscle morphology0.0001415Moderately InformativeDirect
Mammalian Phenotype (MP)embryo phenotype0.0004392Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal nervous system development0.0009624Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal gland morphology0.001122Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.001255Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.009884Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.03903Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.05508Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.1193Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.1886Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.2266Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.2694Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.4028Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.6331Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.8073Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle physiology0.9644Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)normal phenotype0.00003919InformativeDirect
Mammalian Phenotype (MP)abnormal cell differentiation0.000191InformativeDirect
Mammalian Phenotype (MP)perinatal lethality0.0009313InformativeDirect
Mammalian Phenotype (MP)abnormal gas homeostasis0.009135InformativeInherited
Mammalian Phenotype (MP)abnormal neuron number0.01703InformativeInherited
Mammalian Phenotype (MP)abnormal coat appearance0.06081InformativeInherited
Mammalian Phenotype (MP)abnormal sensory neuron morphology0.09246InformativeInherited
Mammalian Phenotype (MP)abnormal brain development0.1InformativeInherited
Mammalian Phenotype (MP)abnormal neuron physiology0.1306InformativeInherited
Mammalian Phenotype (MP)abnormal heart ventricle morphology0.1398InformativeInherited
Mammalian Phenotype (MP)abnormal respiratory function0.2161InformativeInherited
Mammalian Phenotype (MP)abnormal pancreas morphology0.393InformativeInherited
Mammalian Phenotype (MP)abnormal retinal neuronal layer morphology0.6393InformativeInherited
Mammalian Phenotype (MP)abnormal appendicular skeleton morphology0.8631InformativeInherited
Mammalian Phenotype (MP)increased sensory neuron number0.00003154Highly InformativeDirect
Mammalian Phenotype (MP)premature neuronal precursor differentiation0.0001012Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pancreatic acinus morphology0.000158Highly InformativeDirect
Mammalian Phenotype (MP)abnormal breathing pattern0.0003424Highly InformativeDirect
Mammalian Phenotype (MP)thin retinal inner nuclear layer0.0003437Highly InformativeDirect
Mammalian Phenotype (MP)postnatal lethality0.0005017Highly InformativeDirect
Mammalian Phenotype (MP)cyanosis0.0005898Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating estradiol level0.0006635Highly InformativeDirect
Mammalian Phenotype (MP)abnormal skeletal muscle regeneration0.0007726Highly InformativeDirect
Mammalian Phenotype (MP)abnormal amacrine cell morphology0.0008718Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circadian rhythm0.001309Highly InformativeInherited
Mammalian Phenotype (MP)abnormal telencephalon development0.001593Highly InformativeInherited
Mammalian Phenotype (MP)abnormal brain ventricle morphology0.001929Highly InformativeInherited
Mammalian Phenotype (MP)abnormal CNS glial cell morphology0.003772Highly InformativeInherited
Mammalian Phenotype (MP)abnormal circumventricular organ morphology0.004567Highly InformativeInherited
Mammalian Phenotype (MP)decreased sensory neuron number0.05738Highly InformativeInherited
Mammalian Phenotype (MP)abnormal catecholamine level0.2298Highly InformativeInherited
Mammalian Phenotype (MP)abnormal coat/hair pigmentation0.2965Highly InformativeInherited
Mammalian Phenotype (MP)abnormal skeletal muscle fiber morphology0.4331Highly InformativeInherited
Mammalian Phenotype (MP)abnormal pituitary gland morphology0.6854Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell development variant0.000002195Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.000006489Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.0001265Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.0001422Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.001432Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.09586Least InformativeInherited
Worm Phenotype (WP)apoptosis variant0.00279Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.7442Moderately InformativeInherited
Worm Phenotype (WP)pattern of transgene expression variant1Moderately InformativeInherited
Worm Phenotype (WP)RNA expression variant0.0004975InformativeDirect
Worm Phenotype (WP)chemotaxis variant0.002517InformativeInherited
Worm Phenotype (WP)oxygen response variant0.00456InformativeInherited
Worm Phenotype (WP)neuronal outgrowth variant0.8032InformativeInherited
Worm Phenotype (WP)neuronal cell fate specification variant0.000003423Highly InformativeDirect
Worm Phenotype (WP)ectopic expression transgene0.00007303Highly InformativeDirect
Worm Phenotype (WP)aqueous positive chemotaxis defective0.0004995Highly InformativeDirect
Worm Phenotype (WP)nervous system physiology variant0.0005503Highly InformativeDirect
Worm Phenotype (WP)gene expression level reduced0.0006011Highly InformativeDirect
Worm Phenotype (WP)apoptosis reduced0.005451Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect
Yeast Phenotype (YP)metabolism and growth0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)behavior defective0.1719Moderately InformativeInherited
Fly Phenotype (FP)visible0.00000000008494InformativeDirect
Fly Phenotype (FP)circadian rhythm defective0.007743InformativeInherited
Fly Phenotype (FP)locomotor behavior defective0.5967InformativeInherited
Fly Phenotype (FP)circadian behavior defective0.004294Highly InformativeInherited

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

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FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)adult0.000002215Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0.00002048Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0.1187Least InformativeInherited
Fly Anatomy (FA)embryo0.1514Least InformativeInherited
Fly Anatomy (FA)somatic cell0.3025Least InformativeInherited
Fly Anatomy (FA)larva0.4226Least InformativeInherited
Fly Anatomy (FA)nervous system0.4289Least InformativeInherited
Fly Anatomy (FA)anatomical group0.4674Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)adult integumentary system0.006769Moderately InformativeInherited
Fly Anatomy (FA)appendage0.01068Moderately InformativeInherited
Fly Anatomy (FA)adult thorax0.03731Moderately InformativeInherited
Fly Anatomy (FA)neuron0.04434Moderately InformativeInherited
Fly Anatomy (FA)adult segment0.05273Moderately InformativeInherited
Fly Anatomy (FA)cell cluster organ0.1098Moderately InformativeInherited
Fly Anatomy (FA)thoracic segment0.1176Moderately InformativeInherited
Fly Anatomy (FA)tagmatic subdivision of integument0.213Moderately InformativeInherited
Fly Anatomy (FA)sense organ0.2957Moderately InformativeInherited
Fly Anatomy (FA)ganglion0.3395Moderately InformativeInherited
Fly Anatomy (FA)somatic precursor cell0.3429Moderately InformativeInherited
Fly Anatomy (FA)late embryo0.4039Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.667Moderately InformativeInherited
Fly Anatomy (FA)head1Moderately InformativeInherited
Fly Anatomy (FA)chaeta0.006048InformativeInherited
Fly Anatomy (FA)mechanosensory system0.007296InformativeInherited
Fly Anatomy (FA)interneuron0.08792InformativeInherited
Fly Anatomy (FA)ventral nerve cord0.1374InformativeInherited
Fly Anatomy (FA)adult procephalic segment0.214InformativeInherited
Fly Anatomy (FA)neuromere0.2445InformativeInherited
Fly Anatomy (FA)adult external head0.2809InformativeInherited
Fly Anatomy (FA)larval thoracic segment0.3665InformativeInherited
Fly Anatomy (FA)leg0.4488InformativeInherited
Fly Anatomy (FA)sensory mother cell0.00008935Highly InformativeDirect
Fly Anatomy (FA)third segment of antenna0.000666Highly InformativeDirect
Fly Anatomy (FA)5-6I of thorax0.0008472Highly InformativeDirect
Fly Anatomy (FA)head bristle0.02625Highly InformativeInherited
Fly Anatomy (FA)mechanosensory chaeta0.05975Highly InformativeInherited
Fly Anatomy (FA)segment of leg0.2292Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)portion of tissue0.01554Moderately InformativeInherited
Zebrafish Anatomy (ZA)cardiovascular system0.6524Moderately InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.00000227Least InformativeDirect
Xenopus ANatomical entity (XAN)tissue0.0002373Least InformativeDirect
Xenopus ANatomical entity (XAN)nervous system0.004562Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.01955Least InformativeInherited
Xenopus ANatomical entity (XAN)trunk1Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ1Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)sensory system0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)embryonic structure0.00000000000002189Moderately InformativeDirect
Xenopus ANatomical entity (XAN)ectoderm0.02851Moderately InformativeInherited
Xenopus ANatomical entity (XAN)brain0.03294Moderately InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.09945Moderately InformativeInherited
Xenopus ANatomical entity (XAN)alimentary system1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)viscus1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)anatomical direction0InformativeDirect
Xenopus ANatomical entity (XAN)spinal cord7.314e-16InformativeDirect
Xenopus ANatomical entity (XAN)eye0.000000000000002923InformativeDirect
Xenopus ANatomical entity (XAN)neural plate0.0000000000001078InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0.0000000000005479InformativeDirect
Xenopus ANatomical entity (XAN)pharyngeal region0.0000000002852InformativeDirect
Xenopus ANatomical entity (XAN)neuron0.0000000007328InformativeDirect
Xenopus ANatomical entity (XAN)hindbrain0.0000000007764InformativeDirect
Xenopus ANatomical entity (XAN)epithelium0.000000001767InformativeDirect
Xenopus ANatomical entity (XAN)mesenchyme0.000000004291InformativeDirect
Xenopus ANatomical entity (XAN)cranial placode0.0000001115InformativeDirect
Xenopus ANatomical entity (XAN)peripheral nervous system0.0000001541InformativeDirect
Xenopus ANatomical entity (XAN)cardiovascular system0.0000006306InformativeDirect
Xenopus ANatomical entity (XAN)surface structure0.00005183InformativeDirect
Xenopus ANatomical entity (XAN)vestibuloauditory system0.02195InformativeInherited
Xenopus ANatomical entity (XAN)dermal system0.1806InformativeInherited
Xenopus ANatomical entity (XAN)skeletal system0.2668InformativeInherited
Xenopus ANatomical entity (XAN)tail0.5741InformativeInherited
Xenopus ANatomical entity (XAN)skeletal muscle1InformativeInherited
Xenopus ANatomical entity (XAN)proliferative region0.0000000000005718Highly InformativeDirect
Xenopus ANatomical entity (XAN)chordal neural plate0.0000000000005738Highly InformativeDirect
Xenopus ANatomical entity (XAN)neural plate border0.0000000002357Highly InformativeDirect
Xenopus ANatomical entity (XAN)otic vesicle0.000000002417Highly InformativeDirect
Xenopus ANatomical entity (XAN)anterior neural fold0.00000001684Highly InformativeDirect
Xenopus ANatomical entity (XAN)midbrain0.00000005456Highly InformativeDirect
Xenopus ANatomical entity (XAN)forebrain0.0000001063Highly InformativeDirect
Xenopus ANatomical entity (XAN)non-neural ectoderm0.000000306Highly InformativeDirect
Xenopus ANatomical entity (XAN)cranium0.0000003695Highly InformativeDirect
Xenopus ANatomical entity (XAN)optic vesicle0.0000006487Highly InformativeDirect
Xenopus ANatomical entity (XAN)intersomitic region0.0000007949Highly InformativeDirect
Xenopus ANatomical entity (XAN)ganglion0.000001131Highly InformativeDirect
Xenopus ANatomical entity (XAN)trunk musculature0.00000209Highly InformativeDirect
Xenopus ANatomical entity (XAN)neural tube0.000007737Highly InformativeDirect
Xenopus ANatomical entity (XAN)neural groove0.00001575Highly InformativeDirect
Xenopus ANatomical entity (XAN)blastema0.00002534Highly InformativeDirect
Xenopus ANatomical entity (XAN)foregut0.0000337Highly InformativeDirect
Xenopus ANatomical entity (XAN)circulatory system0.00003695Highly InformativeDirect
Xenopus ANatomical entity (XAN)presumptive midbrain-hindbrain boundary0.00006598Highly InformativeDirect
Xenopus ANatomical entity (XAN)chordoneural hinge0.00009426Highly InformativeDirect
Xenopus ANatomical entity (XAN)retinal ganglion cell layer0.00009426Highly InformativeDirect
Xenopus ANatomical entity (XAN)anatomical line0.0001726Highly InformativeDirect
Xenopus ANatomical entity (XAN)involuted ventral mesoderm0.0003157Highly InformativeDirect
Xenopus ANatomical entity (XAN)primordium0.0004732Highly InformativeDirect
Xenopus ANatomical entity (XAN)involuted dorsal mesoderm0.000509Highly InformativeDirect
Xenopus ANatomical entity (XAN)optic field0.000544Highly InformativeDirect
Xenopus ANatomical entity (XAN)cranial nerve0.0005759Highly InformativeDirect
Xenopus ANatomical entity (XAN)marginal zone1Highly InformativeInherited
Xenopus DEvelopment stage (XDE)embryonic stage0.01207Moderately InformativeInherited
Xenopus DEvelopment stage (XDE)late tailbud stage0.7872InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)megasporophyll1Least InformativeInherited
Plant ANatomical entity (PAN)flower1Least InformativeInherited
Plant ANatomical entity (PAN)collective phyllome structure1Least InformativeInherited
Plant ANatomical entity (PAN)root system1Least InformativeInherited
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure1Least InformativeInherited
Plant ANatomical entity (PAN)root epidermis0.0000355InformativeDirect
Plant ANatomical entity (PAN)portion of ground tissue0.003117InformativeInherited
Plant ANatomical entity (PAN)primary root0.0003545Highly InformativeDirect
Plant ANatomical entity (PAN)style0.001016Highly InformativeInherited

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect

Document: EC annotation of SCOP domains

InterPro annotation
Cross references IPR011598 SSF47459 Protein matches
Abstract

The helix-loop-helix (HLH) DNA-binding domain consists of a closed bundle of four helices in a left-handed twist with two crossover connections. The HLH domain directs dimerisation, and is juxtaposed to basic regions to create a DNA interaction interface surface that recognises specific DNA sequences. Basic region/HLH (bHLH) proteins regulate diverse biological pathways [PubMed10710415]. bHLH proteins include MyoD [PubMed12783965], SREBPs (sterol regulatory element binding proteins) [PubMed9634703], and yeast Pho4 (phosphatase system) [PubMed9303313].

In certain proteins the bHLH domain contains a leucine-zipper motif. The bHLH/leucine zipper (bHLHZip) domain specifies dimerisation within a network of proteins and determines sequence-specific DNA binding [PubMed10378692]. bHLHZip domains occur in the transcription factors Myc, Mad, Max and Usf [PubMed12553908, PubMed8306960].

This entry is bHLHZip, which covers the bHLH domain and the leucine zipper motif, when present.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 10 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a HLH, helix-loop-helix DNA-binding domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 10 hidden Markov models representing the HLH, helix-loop-helix DNA-binding domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]