SUPERFAMILY 1.75 HMM library and genome assignments server


EF-hand superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   EF Hand-like [ 47472] (4)
Superfamily:   EF-hand [ 47473] (11)
Families:   Calbindin D9K [ 47474]
  S100 proteins [ 47478]
  Polcalcin [ 89048] (3)
  Osteonectin [ 47489]
  Parvalbumin [ 47492] (2)
  Calmodulin-like [ 47502] (23)
  Eps15 homology domain (EH domain) [ 47543] (3)
  Cbp40 (plasmodial specific CaII-binding protein LAV1-2) [ 81758]
  Penta-EF-hand proteins [ 63550] (6)
  EF-hand modules in multidomain proteins [ 47547] (8)
  p25-alpha [ 140538] (2)


Superfamily statistics
Genomes (1,084) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 59,587 56,593 217
Proteins 52,395 50,361 215


Functional annotation
General category General
Detailed category General

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process5.139e-141.515e-13Least InformativeDirect
Biological Process (BP)developmental process2.443e-072.47e-09Least InformativeDirect
Biological Process (BP)single-organism cellular process00Least InformativeDirect
Biological Process (BP)response to stimulus6.911e-120Least InformativeDirect
Biological Process (BP)localization7.089e-090Least InformativeDirect
Biological Process (BP)cellular component organization or biogenesis07.962e-10Least InformativeDirect
Biological Process (BP)regulation of cellular process0.12290.0006113Least InformativeInherited
Biological Process (BP)regulation of metabolic process11Least InformativeInherited
Biological Process (BP)system process1.926e-061.479e-05Moderately InformativeDirect
Biological Process (BP)signal transduction0.00065424.847e-07Moderately InformativeDirect
Biological Process (BP)regulation of localization0.00078342.083e-09Moderately InformativeDirect
Biological Process (BP)regulation of catalytic activity4.652e-100Moderately InformativeDirect
Biological Process (BP)regulation of programmed cell death0.00011151Moderately InformativeInherited
Biological Process (BP)response to endogenous stimulus0.85550.1293Moderately InformativeInherited
Biological Process (BP)response to organic substance0.91781Moderately InformativeInherited
Biological Process (BP)cellular component biogenesis0.31690.00817Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.029620.7413Moderately InformativeInherited
Biological Process (BP)positive regulation of response to stimulus0.00084610.1274Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.42920.007873Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.20461Moderately InformativeInherited
Biological Process (BP)tissue development0.0097310.01961Moderately InformativeInherited
Biological Process (BP)organ development0.012421Moderately InformativeInherited
Biological Process (BP)reproduction0.0070731Moderately InformativeInherited
Biological Process (BP)cellular localization0.0079720Moderately InformativeInherited
Biological Process (BP)positive regulation of molecular function9.584e-070.007521Moderately InformativeInherited
Biological Process (BP)regulation of macromolecule biosynthetic process0.65861Moderately InformativeInherited
Biological Process (BP)macromolecular complex subunit organization0.10230.0005891Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.03591Moderately InformativeInherited
Biological Process (BP)homeostatic process0.40582.066e-08Moderately InformativeInherited
Biological Process (BP)single-organism developmental process0.84930.862Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process11Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process10.1061Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process0.91951Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.00072111Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process0.00049971Moderately InformativeInherited
Biological Process (BP)organelle organization8.141e-070.007512Moderately InformativeInherited
Biological Process (BP)regulation of phosphate metabolic process13.487e-07Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.0046540.01878Moderately InformativeInherited
Biological Process (BP)ion transport10.03838Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.0013420.2981Moderately InformativeInherited
Biological Process (BP)organic substance transport0.94041Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.39060.006678Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.074360.1157Moderately InformativeInherited
Biological Process (BP)cell differentiation2.54e-060.2445Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.15820.007947Moderately InformativeInherited
Biological Process (BP)nervous system development0.90670.6198Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.03770.0003165Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.85251Moderately InformativeInherited
Biological Process (BP)multi-organism process0.25710.3701Moderately InformativeInherited
Biological Process (BP)immune system process1.765e-080.09092Moderately InformativeInherited
Biological Process (BP)cellular component movement1.006e-051.599e-10InformativeDirect
Biological Process (BP)cytoskeleton organization00InformativeDirect
Biological Process (BP)microtubule-based process1.792e-091.431e-14InformativeDirect
Biological Process (BP)response to wounding1.158e-068.116e-07InformativeDirect
Biological Process (BP)protein transport3.613e-072.593e-06InformativeDirect
Biological Process (BP)metal ion transport0.00065221.758e-06InformativeDirect
Biological Process (BP)actin filament-based process00InformativeDirect
Biological Process (BP)regulation of response to external stimulus1.671e-084.927e-08InformativeDirect
Biological Process (BP)regulation of intracellular transport0.00047651.242e-05InformativeDirect
Biological Process (BP)cellular component morphogenesis6.632e-062.064e-05InformativeDirect
Biological Process (BP)intracellular signal transduction2.732e-050.0005364InformativeDirect
Biological Process (BP)anatomical structure formation involved in morphogenesis0.00066596.268e-13InformativeDirect
Biological Process (BP)positive regulation of transport0.00080465.892e-06InformativeDirect
Biological Process (BP)muscle tissue development1.566e-081.776e-08InformativeDirect
Biological Process (BP)membrane organization9.962e-071.235e-13InformativeDirect
Biological Process (BP)muscle structure development3.143e-110InformativeDirect
Biological Process (BP)regulation of purine nucleotide metabolic process2.073e-084.029e-06InformativeDirect
Biological Process (BP)regulation of apoptotic signaling pathway0.058640.9531InformativeInherited
Biological Process (BP)positive regulation of signal transduction0.27071InformativeInherited
Biological Process (BP)regulation of ion transport0.0042464.099e-10InformativeInherited
Biological Process (BP)positive regulation of immune system process0.25970.6578InformativeInherited
Biological Process (BP)regulation of cellular component movement1.275e-050.02273InformativeInherited
Biological Process (BP)regulation of locomotion9.268e-050.03597InformativeInherited
Biological Process (BP)cellular response to endogenous stimulus0.42490.8447InformativeInherited
Biological Process (BP)regulation of cell cycle0.12881InformativeInherited
Biological Process (BP)negative regulation of cellular component organization0.75430.001822InformativeInherited
Biological Process (BP)regulation of peptidase activity0.27050.1117InformativeInherited
Biological Process (BP)positive regulation of hydrolase activity0.050170.3657InformativeInherited
Biological Process (BP)positive regulation of cell proliferation0.00035710.6506InformativeInherited
Biological Process (BP)transmembrane transport10.9488InformativeInherited
Biological Process (BP)biological adhesion0.00068011InformativeInherited
Biological Process (BP)blood circulation6.167e-150.7011InformativeInherited
Biological Process (BP)response to nutrient levels0.73970.7451InformativeInherited
Biological Process (BP)reproductive structure development0.67991InformativeInherited
Biological Process (BP)organelle localization0.099280.008163InformativeInherited
Biological Process (BP)response to inorganic substance0.013695.91e-08InformativeInherited
Biological Process (BP)protein complex assembly0.95710.05551InformativeInherited
Biological Process (BP)cellular macromolecular complex assembly0.017141InformativeInherited
Biological Process (BP)posttranscriptional regulation of gene expression0.0018941InformativeInherited
Biological Process (BP)vesicle-mediated transport0.029680.1188InformativeInherited
Biological Process (BP)immune effector process10.7567InformativeInherited
Biological Process (BP)secretion by cell0.11840.001475InformativeInherited
Biological Process (BP)cell projection organization0.0026920.9465InformativeInherited
Biological Process (BP)negative regulation of protein metabolic process0.016553.606e-05InformativeInherited
Biological Process (BP)regulation of organelle organization0.70730.4231InformativeInherited
Biological Process (BP)positive regulation of developmental process0.36053.191e-06InformativeInherited
Biological Process (BP)locomotion1.64e-060.001517InformativeInherited
Biological Process (BP)localization of cell0.012671InformativeInherited
Biological Process (BP)organelle assembly0.0020258.308e-10InformativeInherited
Biological Process (BP)generation of neurons0.024350.4023InformativeInherited
Biological Process (BP)regulation of nervous system development0.19190.1974InformativeInherited
Biological Process (BP)regulation of cell development0.40766.498e-06InformativeInherited
Biological Process (BP)positive regulation of macromolecule biosynthetic process0.089781InformativeInherited
Biological Process (BP)positive regulation of cellular biosynthetic process0.38281InformativeInherited
Biological Process (BP)positive regulation of protein metabolic process0.015653.247e-05InformativeInherited
Biological Process (BP)immune response0.0037910.2935InformativeInherited
Biological Process (BP)defense response0.006220.0003856InformativeInherited
Biological Process (BP)response to light stimulus0.0034960.05236InformativeInherited
Biological Process (BP)cell activation0.56770.1787InformativeInherited
Biological Process (BP)myeloid leukocyte activation8.813e-050.0001767Highly InformativeDirect
Biological Process (BP)muscle organ development0.00068870Highly InformativeDirect
Biological Process (BP)detection of light stimulus2.232e-071.859e-08Highly InformativeDirect
Biological Process (BP)cellular component assembly involved in morphogenesis7.441e-095.586e-15Highly InformativeDirect
Biological Process (BP)regulation of neuron projection development7.248e-056.351e-11Highly InformativeDirect
Biological Process (BP)actin filament-based movement4.219e-082.548e-13Highly InformativeDirect
Biological Process (BP)actomyosin structure organization2.631e-063.139e-09Highly InformativeDirect
Biological Process (BP)negative regulation of protein modification process0.00060121.932e-10Highly InformativeDirect
Biological Process (BP)positive regulation of response to external stimulus2.387e-130.0001408Highly InformativeDirect
Biological Process (BP)positive regulation of intracellular transport2.485e-052.735e-06Highly InformativeDirect
Biological Process (BP)regulation of transporter activity1.914e-070Highly InformativeDirect
Biological Process (BP)regulation of mononuclear cell proliferation1.614e-080.0004773Highly InformativeDirect
Biological Process (BP)regulation of transmembrane transport3.661e-060Highly InformativeDirect
Biological Process (BP)negative regulation of protein complex disassembly0.000530Highly InformativeDirect
Biological Process (BP)regulation of smooth muscle cell proliferation3.484e-069.92e-05Highly InformativeDirect
Biological Process (BP)regulation of calcium-mediated signaling3.817e-060.00077Highly InformativeDirect
Biological Process (BP)positive regulation of cell activation8.374e-055.407e-11Highly InformativeDirect
Biological Process (BP)protein polymerization1.501e-101.228e-09Highly InformativeDirect
Biological Process (BP)response to calcium ion9.335e-110Highly InformativeDirect
Biological Process (BP)heart contraction0.00056682.089e-10Highly InformativeDirect
Biological Process (BP)positive regulation of leukocyte proliferation0.00017770.0002393Highly InformativeDirect
Biological Process (BP)regulation of protein depolymerization0.00078380Highly InformativeDirect
Biological Process (BP)regulation of G1/S transition of mitotic cell cycle2.853e-113.357e-10Highly InformativeDirect
Biological Process (BP)regulation of intrinsic apoptotic signaling pathway9.24e-074.527e-05Highly InformativeDirect
Biological Process (BP)positive regulation of apoptotic signaling pathway0.00079720.1223Highly InformativeInherited
Biological Process (BP)regulation of sodium ion transport0.0032060.3483Highly InformativeInherited
Biological Process (BP)regulation of lymphocyte migration0.014850.003892Highly InformativeInherited
Biological Process (BP)positive regulation of cell migration6.167e-150.002228Highly InformativeInherited
Biological Process (BP)cellular response to growth factor stimulus0.58820.9705Highly InformativeInherited
Biological Process (BP)positive regulation of cell cycle process0.00014420.0272Highly InformativeInherited
Biological Process (BP)positive regulation of peptidase activity4.181e-060.3753Highly InformativeInherited
Biological Process (BP)regulation of cysteine-type endopeptidase activity6.295e-081Highly InformativeInherited
Biological Process (BP)cell projection assembly0.0012250.1694Highly InformativeInherited
Biological Process (BP)plasma membrane organization0.00930.03195Highly InformativeInherited
Biological Process (BP)regulation of behavior2.159e-060.08151Highly InformativeInherited
Biological Process (BP)calcium ion transport0.39170.0007355Highly InformativeInherited
Biological Process (BP)ion transmembrane transport0.012430.1646Highly InformativeInherited
Biological Process (BP)cell adhesion0.054551Highly InformativeInherited
Biological Process (BP)fruiting body development0.00016450.003893Highly InformativeInherited
Biological Process (BP)positive regulation of sequence-specific DNA binding transcription factor activity0.26520.001689Highly InformativeInherited
Biological Process (BP)actin filament organization0.00063350.1598Highly InformativeInherited
Biological Process (BP)regulation of protein stability0.00012930.2946Highly InformativeInherited
Biological Process (BP)leukocyte mediated immunity0.60920.1942Highly InformativeInherited
Biological Process (BP)leukocyte activation involved in immune response0.13030.0001519Highly InformativeInherited
Biological Process (BP)exocytosis0.26490.2179Highly InformativeInherited
Biological Process (BP)cell fate commitment0.005170.06274Highly InformativeInherited
Biological Process (BP)regulation of T cell activation1.614e-080.02118Highly InformativeInherited
Biological Process (BP)regulation of proton transport1.226e-050.002105Highly InformativeInherited
Biological Process (BP)regulation of cyclic nucleotide metabolic process2.887e-070.001456Highly InformativeInherited
Biological Process (BP)regulation of myeloid cell differentiation0.0017370.4956Highly InformativeInherited
Biological Process (BP)positive regulation of cell differentiation0.05360.005896Highly InformativeInherited
Biological Process (BP)regulation of leukocyte differentiation0.13351Highly InformativeInherited
Biological Process (BP)chemotaxis0.019810.4304Highly InformativeInherited
Biological Process (BP)regulation of G-protein coupled receptor protein signaling pathway0.071320.004174Highly InformativeInherited
Biological Process (BP)small GTPase mediated signal transduction0.11620.0004419Highly InformativeInherited
Biological Process (BP)G-protein coupled receptor signaling pathway0.29650.9023Highly InformativeInherited
Biological Process (BP)cellular response to radiation0.041550.3478Highly InformativeInherited
Biological Process (BP)innate immune response0.010280.823Highly InformativeInherited
Biological Process (BP)regulation of microtubule polymerization or depolymerization0.38281.789e-07Highly InformativeInherited
Biological Process (BP)negative regulation of cytoskeleton organization0.084847.987e-09Highly InformativeInherited
Biological Process (BP)phagocytosis0.0018461Highly InformativeInherited
Biological Process (BP)leukocyte migration0.00054460.03607Highly InformativeInherited
Biological Process (BP)inflammatory response4.499e-100.001321Highly InformativeInherited
Biological Process (BP)microtubule cytoskeleton organization0.031990.4491Highly InformativeInherited
Molecular Function (MF)binding00Least InformativeDirect
Molecular Function (MF)hydrolase activity10.02085Least InformativeInherited
Molecular Function (MF)structural molecule activity0.00024396.392e-14Moderately InformativeDirect
Molecular Function (MF)enzyme regulator activity6.404e-090Moderately InformativeDirect
Molecular Function (MF)cation binding00Moderately InformativeDirect
Molecular Function (MF)transporter activity10.1613Moderately InformativeInherited
Molecular Function (MF)hydrolase activity, acting on ester bonds10.1338Moderately InformativeInherited
Molecular Function (MF)cytoskeletal protein binding00InformativeDirect
Molecular Function (MF)inorganic cation transmembrane transporter activity0.43370.1791InformativeInherited
Molecular Function (MF)receptor binding0.25021InformativeInherited
Molecular Function (MF)nucleoside-triphosphatase activity0.76331InformativeInherited
Molecular Function (MF)metal ion transmembrane transporter activity0.033174.884e-05InformativeInherited
Molecular Function (MF)enzyme activator activity8.341e-050.8417InformativeInherited
Molecular Function (MF)phosphatase activity0.90851InformativeInherited
Molecular Function (MF)calcium ion binding00Highly InformativeDirect
Molecular Function (MF)phosphatase regulator activity1.256e-058.122e-05Highly InformativeDirect
Molecular Function (MF)protein complex binding0.0036930.2194Highly InformativeInherited
Molecular Function (MF)ion channel activity0.00097390.001309Highly InformativeInherited
Molecular Function (MF)phosphoprotein phosphatase activity0.059290.1812Highly InformativeInherited
Cellular Component (CC)intracellular non-membrane-bounded organelle00Least InformativeDirect
Cellular Component (CC)protein complex05.016e-12Least InformativeDirect
Cellular Component (CC)intracellular organelle part2.298e-060.0007912Least InformativeDirect
Cellular Component (CC)cytoplasmic part10Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)membrane0.0076570Least InformativeInherited
Cellular Component (CC)cytoskeleton00Moderately InformativeDirect
Cellular Component (CC)cell projection00Moderately InformativeDirect
Cellular Component (CC)plasma membrane part0.00066166.19e-06Moderately InformativeDirect
Cellular Component (CC)endoplasmic reticulum0.0079463.65e-08Moderately InformativeInherited
Cellular Component (CC)actin cytoskeleton2.205e-060InformativeDirect
Cellular Component (CC)cell leading edge00InformativeDirect
Cellular Component (CC)contractile fiber part00InformativeDirect
Cellular Component (CC)lytic vacuole0.93821InformativeInherited
Cellular Component (CC)microtubule cytoskeleton11InformativeInherited
Cellular Component (CC)ruffle1.213e-131.442e-09Highly InformativeDirect
Cellular Component (CC)actin filament2.676e-154.09e-14Highly InformativeDirect
Cellular Component (CC)cilium5.741e-060.0001146Highly InformativeDirect
Cellular Component (CC)protein serine/threonine phosphatase complex0.0001560.0002347Highly InformativeDirect
Cellular Component (CC)myosin complex00Highly InformativeDirect
Cellular Component (CC)sarcoplasmic reticulum0.00018172.499e-07Highly InformativeDirect
Cellular Component (CC)cell-substrate junction0.00058159.828e-05Highly InformativeDirect
Cellular Component (CC)leading edge membrane1.202e-080.0009091Highly InformativeDirect
Cellular Component (CC)cell division site part0.00040013.078e-05Highly InformativeDirect
Cellular Component (CC)microtubule organizing center part02.346e-09Highly InformativeDirect
Cellular Component (CC)contractile ring0.00018980.0005303Highly InformativeDirect
Cellular Component (CC)lysosome0.5070.9262Highly InformativeInherited
Cellular Component (CC)centrosome1.026e-050.01717Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)