SUPERFAMILY 1.75 HMM library and genome assignments server

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EF-hand superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   EF Hand-like [ 47472] (4)
Superfamily:   EF-hand [ 47473] (11)
Families:   Calbindin D9K [ 47474]
  S100 proteins [ 47478]
  Polcalcin [ 89048] (3)
  Osteonectin [ 47489]
  Parvalbumin [ 47492] (2)
  Calmodulin-like [ 47502] (23)
  Eps15 homology domain (EH domain) [ 47543] (3)
  Cbp40 (plasmodial specific CaII-binding protein LAV1-2) [ 81758]
  Penta-EF-hand proteins [ 63550] (6)
  EF-hand modules in multidomain proteins [ 47547] (8)
  p25-alpha [ 140538] (2)


Superfamily statistics
Genomes (1,137) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 68,412 81,218 217
Proteins 60,485 72,530 215


Functional annotation
General category General
Detailed category General

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism cellular process0.000018990Least InformativeDirect
Biological Process (BP)response to stimulus0.0000000027720.00000000002666Least InformativeDirect
Biological Process (BP)biological regulation0.0000000000000059440.000000000001534Least InformativeDirect
Biological Process (BP)cellular component organization or biogenesis0.000000000016740Least InformativeDirect
Biological Process (BP)organelle organization0.0001280Moderately InformativeDirect
Biological Process (BP)cell communication0.000021590.0002243Moderately InformativeDirect
Biological Process (BP)signaling0.00000001810Moderately InformativeDirect
Biological Process (BP)cellular localization0.000014890.0000002368Moderately InformativeDirect
Biological Process (BP)regulation of molecular function0.000012170.00000001167Moderately InformativeDirect
Biological Process (BP)regulation of cell communication0.012040.0001189Moderately InformativeInherited
Biological Process (BP)response to organic substance0.92261Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.078490.001086Moderately InformativeInherited
Biological Process (BP)immune system process0.0000024510.4441Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.0032260.006746Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.0029790.777Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.0036480.8437Moderately InformativeInherited
Biological Process (BP)single-organism transport0.038750.2108Moderately InformativeInherited
Biological Process (BP)organic substance transport0.86481Moderately InformativeInherited
Biological Process (BP)regulation of response to stimulus0.014910.187Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.00038930.01388Moderately InformativeInherited
Biological Process (BP)response to external stimulus10.9756Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.0099250.7896Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound10.9691Moderately InformativeInherited
Biological Process (BP)system development0.16710.5589Moderately InformativeInherited
Biological Process (BP)macromolecular complex subunit organization0.87551Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.56111Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.15650.0000001069Moderately InformativeInherited
Biological Process (BP)cellular developmental process0.01780.0000006417Moderately InformativeInherited
Biological Process (BP)regulation of localization0.0016380.000000000000009009Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.052370.009673Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process0.8651Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process11Moderately InformativeInherited
Biological Process (BP)regulation of biosynthetic process0.0075441Moderately InformativeInherited
Biological Process (BP)regulation of cellular metabolic process0.96131Moderately InformativeInherited
Biological Process (BP)regulation of nitrogen compound metabolic process0.010911Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.045711Moderately InformativeInherited
Biological Process (BP)cellular component assembly0.33120Moderately InformativeInherited
Biological Process (BP)regulation of signaling0.013120.00001049Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.1960.002846Moderately InformativeInherited
Biological Process (BP)response to stress0.93321Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.37920.0000000004044Moderately InformativeInherited
Biological Process (BP)cytoskeleton organization00InformativeDirect
Biological Process (BP)microtubule-based process00.000000000009217InformativeDirect
Biological Process (BP)vesicle-mediated transport0.0000000011920.000005068InformativeDirect
Biological Process (BP)actin filament-based process00InformativeDirect
Biological Process (BP)regulation of response to external stimulus0.00000016030.000003544InformativeDirect
Biological Process (BP)positive regulation of cellular protein metabolic process0.00075650.0002049InformativeDirect
Biological Process (BP)cellular component morphogenesis0.000036710InformativeDirect
Biological Process (BP)response to cytokine0.00036610.000297InformativeDirect
Biological Process (BP)regulation of transmembrane transport0.00039970InformativeDirect
Biological Process (BP)locomotion0.000095990.0001389InformativeDirect
Biological Process (BP)regulation of ion transport0.00079440.00000000000004691InformativeDirect
Biological Process (BP)cell development0.00055370.0000000000008563InformativeDirect
Biological Process (BP)ion homeostasis0.000000020620.00000007239InformativeDirect
Biological Process (BP)positive regulation of signal transduction0.6511InformativeInherited
Biological Process (BP)positive regulation of cell death0.022670.1947InformativeInherited
Biological Process (BP)regulation of apoptotic process0.0004671InformativeInherited
Biological Process (BP)secretion0.042310.2876InformativeInherited
Biological Process (BP)movement of cell or subcellular component0.0007130.001189InformativeInherited
Biological Process (BP)positive regulation of cellular component organization0.45280.08546InformativeInherited
Biological Process (BP)regulation of cellular localization0.065740.5168InformativeInherited
Biological Process (BP)positive regulation of immune system process0.019410.3023InformativeInherited
Biological Process (BP)protein targeting0.95311InformativeInherited
Biological Process (BP)single-organism intracellular transport0.001380.0004389InformativeInherited
Biological Process (BP)single-organism membrane organization0.0016990.000000000008275InformativeInherited
Biological Process (BP)regulation of locomotion0.00055810.0109InformativeInherited
Biological Process (BP)regulation of cellular component movement0.0002170.01711InformativeInherited
Biological Process (BP)response to organic cyclic compound0.92610.2473InformativeInherited
Biological Process (BP)response to nitrogen compound10.09731InformativeInherited
Biological Process (BP)cellular response to oxygen-containing compound11InformativeInherited
Biological Process (BP)cell adhesion0.000089510.9274InformativeInherited
Biological Process (BP)system process0.00000075070.007653InformativeInherited
Biological Process (BP)regulation of hydrolase activity0.28351InformativeInherited
Biological Process (BP)cellular macromolecular complex assembly0.0000086661InformativeInherited
Biological Process (BP)regulation of transcription, DNA-templated0.0077361InformativeInherited
Biological Process (BP)regulation of intracellular signal transduction0.0036530.9691InformativeInherited
Biological Process (BP)negative regulation of cell communication0.046390.03557InformativeInherited
Biological Process (BP)negative regulation of signaling0.021040.03883InformativeInherited
Biological Process (BP)negative regulation of response to stimulus0.240.1837InformativeInherited
Biological Process (BP)embryo development11InformativeInherited
Biological Process (BP)animal organ morphogenesis0.27460.6241InformativeInherited
Biological Process (BP)regulation of cell cycle0.037131InformativeInherited
Biological Process (BP)regulation of proteolysis0.063860.00000000007192InformativeInherited
Biological Process (BP)regulation of cell proliferation0.0060870.929InformativeInherited
Biological Process (BP)response to radiation0.77421InformativeInherited
Biological Process (BP)regulation of protein localization0.73491InformativeInherited
Biological Process (BP)positive regulation of transport0.0091810.0001932InformativeInherited
Biological Process (BP)regulation of protein modification process0.9620.536InformativeInherited
Biological Process (BP)negative regulation of cellular protein metabolic process0.52670.0000008596InformativeInherited
Biological Process (BP)regulation of organelle organization0.99060.5187InformativeInherited
Biological Process (BP)positive regulation of phosphate metabolic process0.50230.9262InformativeInherited
Biological Process (BP)positive regulation of nitrogen compound metabolic process0.16831InformativeInherited
Biological Process (BP)anatomical structure formation involved in morphogenesis0.0099990InformativeInherited
Biological Process (BP)organelle assembly0.058440InformativeInherited
Biological Process (BP)intracellular signal transduction0.0096430.3359InformativeInherited
Biological Process (BP)regulation of cell differentiation0.13060.02193InformativeInherited
Biological Process (BP)generation of neurons0.2180.02068InformativeInherited
Biological Process (BP)regulation of nervous system development0.12540.02983InformativeInherited
Biological Process (BP)positive regulation of developmental process0.61420.000002362InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis0.28070.4488InformativeInherited
Biological Process (BP)positive regulation of macromolecule biosynthetic process0.28391InformativeInherited
Biological Process (BP)positive regulation of cellular biosynthetic process0.050921InformativeInherited
Biological Process (BP)negative regulation of cellular component organization0.60.007294InformativeInherited
Biological Process (BP)response to inorganic substance0.0012180.0000008307InformativeInherited
Biological Process (BP)positive regulation of multicellular organismal process0.83190.3992InformativeInherited
Biological Process (BP)regulation of system process0.0021490.004763InformativeInherited
Biological Process (BP)regulation of leukocyte migration0.000000074590.0000001977Highly InformativeDirect
Biological Process (BP)muscle system process0.0000000069360.000000000000003692Highly InformativeDirect
Biological Process (BP)inflammatory response0.0000000000047480.000003624Highly InformativeDirect
Biological Process (BP)cellular component assembly involved in morphogenesis0.00000033580Highly InformativeDirect
Biological Process (BP)regulation of neuron projection development0.00011950.0000005319Highly InformativeDirect
Biological Process (BP)calcium-mediated signaling0.00000000060280Highly InformativeDirect
Biological Process (BP)actomyosin structure organization0.00097140Highly InformativeDirect
Biological Process (BP)negative regulation of protein modification process0.00036310.000004071Highly InformativeDirect
Biological Process (BP)positive regulation of response to external stimulus0.00000000000076090.00007933Highly InformativeDirect
Biological Process (BP)positive regulation of transporter activity0.00000047510.000000000004736Highly InformativeDirect
Biological Process (BP)positive regulation of transmembrane transport0.0000120.000000000001265Highly InformativeDirect
Biological Process (BP)positive regulation of proteolysis0.00010980.0000003624Highly InformativeDirect
Biological Process (BP)positive regulation of mitotic cell cycle0.000000035480.00004433Highly InformativeDirect
Biological Process (BP)regulation of smooth muscle cell proliferation0.0000064850.0003216Highly InformativeDirect
Biological Process (BP)regulation of calcium-mediated signaling0.000020480.00000001114Highly InformativeDirect
Biological Process (BP)protein polymerization0.00000000099050.000000003971Highly InformativeDirect
Biological Process (BP)response to calcium ion0.0000000000000030420Highly InformativeDirect
Biological Process (BP)heart contraction0.000006590.000000005109Highly InformativeDirect
Biological Process (BP)muscle structure development0.00000015440Highly InformativeDirect
Biological Process (BP)positive regulation of cell cycle process0.00090260.0003863Highly InformativeDirect
Biological Process (BP)vesicle-mediated transport to the plasma membrane0.0000014620.0001192Highly InformativeDirect
Biological Process (BP)regulation of purine nucleotide metabolic process0.000055410.0007875Highly InformativeDirect
Biological Process (BP)regulation of mitotic cell cycle phase transition0.0000000034240.0004316Highly InformativeDirect
Biological Process (BP)negative regulation of cellular protein localization0.00025290.0009298Highly InformativeDirect
Biological Process (BP)regulation of cation transmembrane transport0.00000000076320.0006722Highly InformativeDirect
Biological Process (BP)positive regulation of apoptotic process0.0011711Highly InformativeInherited
Biological Process (BP)regulation of apoptotic signaling pathway0.0019210.3852Highly InformativeInherited
Biological Process (BP)cellular response to growth factor stimulus0.39840.9877Highly InformativeInherited
Biological Process (BP)positive regulation of cellular protein localization0.0000035870.007894Highly InformativeInherited
Biological Process (BP)synaptic signaling0.070220.5836Highly InformativeInherited
Biological Process (BP)signal release0.060380.3177Highly InformativeInherited
Biological Process (BP)cell projection organization0.00000080580.2215Highly InformativeInherited
Biological Process (BP)positive regulation of intracellular transport0.0000030230.2687Highly InformativeInherited
Biological Process (BP)positive regulation of cell migration0.000000000000096310.009428Highly InformativeInherited
Biological Process (BP)endomembrane system organization0.0038460.006461Highly InformativeInherited
Biological Process (BP)establishment of protein localization to membrane0.00074260.001278Highly InformativeInherited
Biological Process (BP)chemotaxis0.036620.09775Highly InformativeInherited
Biological Process (BP)cellular response to abiotic stimulus0.20660.09525Highly InformativeInherited
Biological Process (BP)response to organophosphorus0.051210.00000000009334Highly InformativeInherited
Biological Process (BP)cellular response to organonitrogen compound0.53640.04397Highly InformativeInherited
Biological Process (BP)leukocyte cell-cell adhesion0.13110.061Highly InformativeInherited
Biological Process (BP)regulation of sequence-specific DNA binding transcription factor activity0.0030080.00000003422Highly InformativeInherited
Biological Process (BP)actin filament organization0.000170.003209Highly InformativeInherited
Biological Process (BP)negative regulation of intracellular signal transduction0.0015650.834Highly InformativeInherited
Biological Process (BP)positive regulation of lymphocyte activation0.0000000050130.008018Highly InformativeInherited
Biological Process (BP)positive regulation of leukocyte proliferation0.00049520.001939Highly InformativeInherited
Biological Process (BP)inner ear development0.062920.6675Highly InformativeInherited
Biological Process (BP)tube morphogenesis0.49960.002696Highly InformativeInherited
Biological Process (BP)embryonic organ morphogenesis0.11270.5119Highly InformativeInherited
Biological Process (BP)sensory organ morphogenesis0.13691Highly InformativeInherited
Biological Process (BP)regulation of lymphocyte proliferation0.000000014860.001934Highly InformativeInherited
Biological Process (BP)regulation of T cell activation0.0000000056230.006343Highly InformativeInherited
Biological Process (BP)positive regulation of cell adhesion0.00000098060.00716Highly InformativeInherited
Biological Process (BP)cell morphogenesis involved in differentiation0.088431Highly InformativeInherited
Biological Process (BP)positive regulation of ion transport0.0026130.000003046Highly InformativeInherited
Biological Process (BP)response to purine-containing compound0.0077560Highly InformativeInherited
Biological Process (BP)regulation of transmembrane transporter activity0.00013090.6082Highly InformativeInherited
Biological Process (BP)regulation of cyclic nucleotide metabolic process0.0000025690.3217Highly InformativeInherited
Biological Process (BP)negative regulation of cytoskeleton organization0.067780.00000002251Highly InformativeInherited
Biological Process (BP)regulation of leukocyte differentiation0.089530.9637Highly InformativeInherited
Biological Process (BP)positive regulation of nucleotide metabolic process0.0062830.04182Highly InformativeInherited
Biological Process (BP)regulation of G-protein coupled receptor protein signaling pathway0.087450.0007866Highly InformativeInherited
Biological Process (BP)small GTPase mediated signal transduction0.025810.000877Highly InformativeInherited
Biological Process (BP)positive regulation of cell development0.3680.007455Highly InformativeInherited
Biological Process (BP)regulation of cell morphogenesis involved in differentiation0.37370.008209Highly InformativeInherited
Biological Process (BP)regulation of protein complex disassembly0.094640.0000000001094Highly InformativeInherited
Biological Process (BP)endocytosis11Highly InformativeInherited
Biological Process (BP)detection of stimulus0.0017250.02088Highly InformativeInherited
Biological Process (BP)cell migration0.16611Highly InformativeInherited
Biological Process (BP)microtubule cytoskeleton organization0.000000034080.8227Highly InformativeInherited
Molecular Function (MF)binding00Least InformativeDirect
Molecular Function (MF)hydrolase activity10.0002239Least InformativeInherited
Molecular Function (MF)metal ion binding00Moderately InformativeDirect
Molecular Function (MF)molecular function regulator0.000000000043580Moderately InformativeDirect
Molecular Function (MF)protein binding10.4062Moderately InformativeInherited
Molecular Function (MF)hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides11Moderately InformativeInherited
Molecular Function (MF)structural molecule activity0.0058420.00000000000008927Moderately InformativeInherited
Molecular Function (MF)transporter activity10.8415Moderately InformativeInherited
Molecular Function (MF)hydrolase activity, acting on ester bonds10.0000000000001191Moderately InformativeInherited
Molecular Function (MF)cytoskeletal protein binding00InformativeDirect
Molecular Function (MF)macromolecular complex binding0.0023541InformativeInherited
Molecular Function (MF)receptor binding0.6131InformativeInherited
Molecular Function (MF)identical protein binding0.018470.00000000002384InformativeInherited
Molecular Function (MF)protein dimerization activity0.002510.0000000000001389InformativeInherited
Molecular Function (MF)ATPase activity0.53151InformativeInherited
Molecular Function (MF)enzyme activator activity0.0000053281InformativeInherited
Molecular Function (MF)metal ion transmembrane transporter activity0.083110.001043InformativeInherited
Molecular Function (MF)passive transmembrane transporter activity0.1440.002332InformativeInherited
Molecular Function (MF)phosphoric ester hydrolase activity10InformativeInherited
Molecular Function (MF)calcium ion binding00Highly InformativeDirect
Molecular Function (MF)protein homodimerization activity0.00056538.405e-16Highly InformativeDirect
Molecular Function (MF)actin filament binding0.00000080920.0000009848Highly InformativeDirect
Molecular Function (MF)ion channel activity0.0017780.002757Highly InformativeInherited
Molecular Function (MF)phosphoprotein phosphatase activity0.077610.08926Highly InformativeInherited
Cellular Component (CC)non-membrane-bounded organelle00Least InformativeDirect
Cellular Component (CC)cytoplasmic part10Least InformativeInherited
Cellular Component (CC)membrane0.15580Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.0011560.000008282Least InformativeInherited
Cellular Component (CC)protein complex0.000063820.007596Least InformativeInherited
Cellular Component (CC)cytoskeleton00Moderately InformativeDirect
Cellular Component (CC)cell projection00Moderately InformativeDirect
Cellular Component (CC)vesicle0.019630.000000005792Moderately InformativeInherited
Cellular Component (CC)extracellular region part0.1480.002561Moderately InformativeInherited
Cellular Component (CC)plasma membrane0.041910Moderately InformativeInherited
Cellular Component (CC)cilium0.00017840.0002606InformativeDirect
Cellular Component (CC)actin cytoskeleton0.0000000002280InformativeDirect
Cellular Component (CC)site of polarized growth0.000027190.000000000817InformativeDirect
Cellular Component (CC)cell projection part00InformativeDirect
Cellular Component (CC)synapse0.0000095960InformativeDirect
Cellular Component (CC)side of membrane0.010270.5406InformativeInherited
Cellular Component (CC)cell junction0.03250InformativeInherited
Cellular Component (CC)extracellular organelle0.027670.000138InformativeInherited
Cellular Component (CC)extrinsic component of membrane0.002070.07534InformativeInherited
Cellular Component (CC)ruffle0.000000000068080.00009453Highly InformativeDirect
Cellular Component (CC)protein serine/threonine phosphatase complex0.00015690.0002153Highly InformativeDirect
Cellular Component (CC)sarcoplasm0.000000022870Highly InformativeDirect
Cellular Component (CC)lamellipodium0.0000000028680Highly InformativeDirect
Cellular Component (CC)extrinsic component of cytoplasmic side of plasma membrane0.00060510.0001179Highly InformativeDirect
Cellular Component (CC)cell division site0.00069920.0008675Highly InformativeDirect
Cellular Component (CC)contractile fiber part00Highly InformativeDirect
Cellular Component (CC)extracellular exosome0.00018260.0000001106Highly InformativeDirect
Cellular Component (CC)anchoring junction0.00024030Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)