SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.


EF-hand superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   EF Hand-like [ 47472] (4)
Superfamily:   EF-hand [ 47473] (11)
Families:   Calbindin D9K [ 47474]
  S100 proteins [ 47478]
  Polcalcin [ 89048] (3)
  Osteonectin [ 47489]
  Parvalbumin [ 47492] (2)
  Calmodulin-like [ 47502] (23)
  Eps15 homology domain (EH domain) [ 47543] (3)
  Cbp40 (plasmodial specific CaII-binding protein LAV1-2) [ 81758]
  Penta-EF-hand proteins [ 63550] (6)
  EF-hand modules in multidomain proteins [ 47547] (8)
  p25-alpha [ 140538] (2)


Superfamily statistics
Genomes (1,141) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 69,394 81,218 217
Proteins 61,377 72,530 215


Functional annotation
General category General
Detailed category General

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus0.000000077920.0000000001439Least InformativeDirect
Biological Process (BP)biological regulation0.000000000000064040.0000000000002635Least InformativeDirect
Biological Process (BP)cellular component organization or biogenesis0.00000000007460Least InformativeDirect
Biological Process (BP)single-organism cellular process0.010090Least InformativeInherited
Biological Process (BP)organelle organization0.00096410.00000003747Moderately InformativeDirect
Biological Process (BP)cell communication0.000000190.000000008037Moderately InformativeDirect
Biological Process (BP)regulation of localization0.00013190Moderately InformativeDirect
Biological Process (BP)single organism signaling0.000000054960.0000002211Moderately InformativeDirect
Biological Process (BP)cellular developmental process0.000020880.0000000002451Moderately InformativeDirect
Biological Process (BP)cellular localization0.00013010Moderately InformativeDirect
Biological Process (BP)regulation of molecular function0.000013550.000000004929Moderately InformativeDirect
Biological Process (BP)macromolecule localization0.0068391Moderately InformativeInherited
Biological Process (BP)response to organic substance0.78051Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.11280.00589Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.064180.04472Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.020990.001607Moderately InformativeInherited
Biological Process (BP)single-organism transport0.0024780.2286Moderately InformativeInherited
Biological Process (BP)organic substance transport11Moderately InformativeInherited
Biological Process (BP)nitrogen compound transport0.50571Moderately InformativeInherited
Biological Process (BP)regulation of response to stimulus0.00065220.04067Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.00052550.005662Moderately InformativeInherited
Biological Process (BP)macromolecular complex subunit organization0.70820.3986Moderately InformativeInherited
Biological Process (BP)cellular component assembly0.20760Moderately InformativeInherited
Biological Process (BP)protein complex biogenesis0.0059220.0333Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process0.043321Moderately InformativeInherited
Biological Process (BP)regulation of macromolecule biosynthetic process0.26521Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.80131Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.085930.00000000000007709Moderately InformativeInherited
Biological Process (BP)system development0.16960.5752Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.0030930.8816Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.072111Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.018670.7597Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound11Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.054781Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process11Moderately InformativeInherited
Biological Process (BP)response to external stimulus11Moderately InformativeInherited
Biological Process (BP)immune system process0.00000033970.17Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.057020.00000001822Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.10710.005953Moderately InformativeInherited
Biological Process (BP)regulation of signaling0.0047990.000003677Moderately InformativeInherited
Biological Process (BP)regulation of cell communication0.0062110.0000557Moderately InformativeInherited
Biological Process (BP)movement of cell or subcellular component0.00058150.0008724InformativeDirect
Biological Process (BP)cytoskeleton organization00InformativeDirect
Biological Process (BP)microtubule-based process00InformativeDirect
Biological Process (BP)vesicle-mediated transport0.000000015960.000001266InformativeDirect
Biological Process (BP)actin filament-based process00InformativeDirect
Biological Process (BP)regulation of response to external stimulus0.000001560.0000007994InformativeDirect
Biological Process (BP)positive regulation of cellular protein metabolic process0.000084480.00001521InformativeDirect
Biological Process (BP)secretion by cell0.00040570.0000316InformativeDirect
Biological Process (BP)cellular component morphogenesis0.0000050820InformativeDirect
Biological Process (BP)response to cytokine0.00013950.0002219InformativeDirect
Biological Process (BP)regulation of transmembrane transport0.000048130InformativeDirect
Biological Process (BP)locomotion0.00077570.0007026InformativeDirect
Biological Process (BP)regulation of ion transport0.00011030.00000000000002971InformativeDirect
Biological Process (BP)cell development0.000055530.0000000000003479InformativeDirect
Biological Process (BP)anatomical structure formation involved in morphogenesis0.00030880InformativeDirect
Biological Process (BP)ion homeostasis0.000000006250.0000000004409InformativeDirect
Biological Process (BP)membrane organization0.00000000094620.0000000000003209InformativeDirect
Biological Process (BP)supramolecular fiber organization00InformativeDirect
Biological Process (BP)positive regulation of cell death0.024480.2521InformativeInherited
Biological Process (BP)regulation of apoptotic process0.00052381InformativeInherited
Biological Process (BP)regulation of protein modification process0.51790.126InformativeInherited
Biological Process (BP)regulation of cell cycle0.064621InformativeInherited
Biological Process (BP)cell-cell signaling0.1250.0001342InformativeInherited
Biological Process (BP)regulation of peptide transport0.19011InformativeInherited
Biological Process (BP)intracellular protein transport0.017831InformativeInherited
Biological Process (BP)single-organism intracellular transport0.0019380.03154InformativeInherited
Biological Process (BP)response to organic cyclic compound0.98140.1651InformativeInherited
Biological Process (BP)response to nitrogen compound10.4373InformativeInherited
Biological Process (BP)cellular response to oxygen-containing compound11InformativeInherited
Biological Process (BP)cellular response to inorganic substance0.56180.00000003096InformativeInherited
Biological Process (BP)regulation of intracellular signal transduction0.0047860.9011InformativeInherited
Biological Process (BP)tissue development0.64860.000007071InformativeInherited
Biological Process (BP)regulation of proteolysis0.16760.00000001102InformativeInherited
Biological Process (BP)regulation of hydrolase activity0.32491InformativeInherited
Biological Process (BP)response to metal ion0.028110.000004404InformativeInherited
Biological Process (BP)cellular protein complex assembly0.00000072170.8252InformativeInherited
Biological Process (BP)regulation of transcription, DNA-templated0.018121InformativeInherited
Biological Process (BP)positive regulation of signal transduction0.75711InformativeInherited
Biological Process (BP)negative regulation of cell communication0.020360.03384InformativeInherited
Biological Process (BP)negative regulation of signaling0.010010.03195InformativeInherited
Biological Process (BP)negative regulation of response to stimulus0.22640.21InformativeInherited
Biological Process (BP)sensory organ development0.63390.1704InformativeInherited
Biological Process (BP)embryo development0.81151InformativeInherited
Biological Process (BP)animal organ morphogenesis0.28170.5701InformativeInherited
Biological Process (BP)organelle localization0.051190.172InformativeInherited
Biological Process (BP)regulation of cell proliferation0.002830.9274InformativeInherited
Biological Process (BP)response to radiation0.77691InformativeInherited
Biological Process (BP)immune response0.00082080.4813InformativeInherited
Biological Process (BP)regulation of establishment of protein localization0.12370.2904InformativeInherited
Biological Process (BP)regulation of cellular localization0.17420.2674InformativeInherited
Biological Process (BP)positive regulation of transport0.012710.0006413InformativeInherited
Biological Process (BP)regulation of organelle organization11InformativeInherited
Biological Process (BP)positive regulation of developmental process0.3980.000005006InformativeInherited
Biological Process (BP)positive regulation of multicellular organismal process0.61470.3676InformativeInherited
Biological Process (BP)positive regulation of nucleobase-containing compound metabolic process0.31961InformativeInherited
Biological Process (BP)positive regulation of phosphate metabolic process0.55410.9384InformativeInherited
Biological Process (BP)organelle assembly0.10620InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis0.11870.1891InformativeInherited
Biological Process (BP)intracellular signal transduction0.027860.3724InformativeInherited
Biological Process (BP)generation of neurons0.76250.1639InformativeInherited
Biological Process (BP)regulation of nervous system development0.022980.01288InformativeInherited
Biological Process (BP)regulation of cell differentiation0.053640.03751InformativeInherited
Biological Process (BP)positive regulation of cellular component organization10.3643InformativeInherited
Biological Process (BP)positive regulation of macromolecule biosynthetic process0.26111InformativeInherited
Biological Process (BP)positive regulation of cellular biosynthetic process0.067881InformativeInherited
Biological Process (BP)system process0.0000000090690.008059InformativeInherited
Biological Process (BP)negative regulation of cellular component organization0.57980.01575InformativeInherited
Biological Process (BP)regulation of locomotion0.000036530.006438InformativeInherited
Biological Process (BP)regulation of cellular component movement0.000013920.006421InformativeInherited
Biological Process (BP)immune effector process0.97110.06102InformativeInherited
Biological Process (BP)cell activation0.00014940.001835InformativeInherited
Biological Process (BP)regulation of system process0.00047970.001584InformativeInherited
Biological Process (BP)regulation of leukocyte migration0.00000060240.0000001051Highly InformativeDirect
Biological Process (BP)muscle system process0.000000028080Highly InformativeDirect
Biological Process (BP)inflammatory response0.00000000000019630.000001531Highly InformativeDirect
Biological Process (BP)cellular component assembly involved in morphogenesis0.0000000016340Highly InformativeDirect
Biological Process (BP)regulation of neuron projection development0.0000051780.000000167Highly InformativeDirect
Biological Process (BP)calcium-mediated signaling0.000000012170.0000000000001701Highly InformativeDirect
Biological Process (BP)positive regulation of response to external stimulus0.000000000001450.0001994Highly InformativeDirect
Biological Process (BP)positive regulation of transporter activity0.00000010090.000000000000904Highly InformativeDirect
Biological Process (BP)positive regulation of transmembrane transport0.0000051780.000000000002128Highly InformativeDirect
Biological Process (BP)neutrophil activation0.00086340.0006259Highly InformativeDirect
Biological Process (BP)leukocyte degranulation0.00003340.0001666Highly InformativeDirect
Biological Process (BP)positive regulation of proteolysis0.000071620.00000209Highly InformativeDirect
Biological Process (BP)regulation of smooth muscle cell proliferation0.0000019690.0001047Highly InformativeDirect
Biological Process (BP)regulation of lymphocyte proliferation0.0000000017430.0009439Highly InformativeDirect
Biological Process (BP)regulation of calcium-mediated signaling0.0000032620.0000000004275Highly InformativeDirect
Biological Process (BP)protein polymerization0.00000000063780.000000001677Highly InformativeDirect
Biological Process (BP)heart contraction0.0000066660.000000008869Highly InformativeDirect
Biological Process (BP)muscle structure development0.000000015670Highly InformativeDirect
Biological Process (BP)positive regulation of leukocyte proliferation0.0001870.0008313Highly InformativeDirect
Biological Process (BP)cellular response to calcium ion0.0000040790.00000000000003137Highly InformativeDirect
Biological Process (BP)plasma membrane bounded cell projection organization0.000000000046090.0005402Highly InformativeDirect
Biological Process (BP)positive regulation of mitotic cell cycle phase transition0.0000023920.00000002142Highly InformativeDirect
Biological Process (BP)regulation of protein modification by small protein conjugation or removal0.00058220.000000000007223Highly InformativeDirect
Biological Process (BP)positive regulation of apoptotic process0.0015151Highly InformativeInherited
Biological Process (BP)regulation of apoptotic signaling pathway0.0024780.4301Highly InformativeInherited
Biological Process (BP)cellular response to growth factor stimulus0.44181Highly InformativeInherited
Biological Process (BP)signal release0.094870.3058Highly InformativeInherited
Biological Process (BP)trans-synaptic signaling0.013310.00005143Highly InformativeInherited
Biological Process (BP)cell projection assembly0.0000045440.3275Highly InformativeInherited
Biological Process (BP)positive regulation of intracellular transport0.000050270.0108Highly InformativeInherited
Biological Process (BP)positive regulation of protein transport0.0023491Highly InformativeInherited
Biological Process (BP)positive regulation of cellular protein localization0.000019320.01735Highly InformativeInherited
Biological Process (BP)endomembrane system organization0.0037910.0162Highly InformativeInherited
Biological Process (BP)positive regulation of cell migration0.000000000000025970.007565Highly InformativeInherited
Biological Process (BP)chemotaxis0.037160.1234Highly InformativeInherited
Biological Process (BP)cellular response to abiotic stimulus0.30770.1348Highly InformativeInherited
Biological Process (BP)response to organophosphorus0.05810.000000000005945Highly InformativeInherited
Biological Process (BP)cellular response to organonitrogen compound0.54920.02632Highly InformativeInherited
Biological Process (BP)biological adhesion0.0000035690.7554Highly InformativeInherited
Biological Process (BP)regulation of sequence-specific DNA binding transcription factor activity0.0017420.000000136Highly InformativeInherited
Biological Process (BP)actin filament organization0.97571Highly InformativeInherited
Biological Process (BP)neurological system process11Highly InformativeInherited
Biological Process (BP)regulation of T cell activation0.0000000006840.00384Highly InformativeInherited
Biological Process (BP)negative regulation of intracellular signal transduction0.00065010.7505Highly InformativeInherited
Biological Process (BP)inner ear development0.079250.753Highly InformativeInherited
Biological Process (BP)tube morphogenesis0.4560.002312Highly InformativeInherited
Biological Process (BP)embryonic organ morphogenesis0.1280.713Highly InformativeInherited
Biological Process (BP)sensory organ morphogenesis0.10910.944Highly InformativeInherited
Biological Process (BP)vesicle localization0.60920.2395Highly InformativeInherited
Biological Process (BP)Golgi vesicle transport10.8375Highly InformativeInherited
Biological Process (BP)regulation of protein complex disassembly0.05780.00000000006258Highly InformativeInherited
Biological Process (BP)positive regulation of cell adhesion0.00000033670.004749Highly InformativeInherited
Biological Process (BP)positive regulation of lymphocyte activation0.00000000060530.004913Highly InformativeInherited
Biological Process (BP)cell morphogenesis involved in differentiation0.24331Highly InformativeInherited
Biological Process (BP)innate immune response0.00012480.7519Highly InformativeInherited
Biological Process (BP)response to purine-containing compound0.0085120Highly InformativeInherited
Biological Process (BP)positive regulation of ion transport0.0013750.000001858Highly InformativeInherited
Biological Process (BP)regulation of cation transmembrane transport0.000000000021190.002331Highly InformativeInherited
Biological Process (BP)regulation of transmembrane transporter activity0.000048830.4681Highly InformativeInherited
Biological Process (BP)regulation of microtubule-based process0.0021320.000000002101Highly InformativeInherited
Biological Process (BP)regulation of leukocyte differentiation0.13180.9815Highly InformativeInherited
Biological Process (BP)regulation of cyclic nucleotide metabolic process0.00002320.4346Highly InformativeInherited
Biological Process (BP)regulation of purine nucleotide metabolic process0.00036850.004465Highly InformativeInherited
Biological Process (BP)positive regulation of nucleotide metabolic process0.019810.1466Highly InformativeInherited
Biological Process (BP)actomyosin structure organization0.0022750Highly InformativeInherited
Biological Process (BP)regulation of G-protein coupled receptor protein signaling pathway0.034560.0001772Highly InformativeInherited
Biological Process (BP)small GTPase mediated signal transduction0.013070.0004424Highly InformativeInherited
Biological Process (BP)positive regulation of cell development0.33730.004882Highly InformativeInherited
Biological Process (BP)regulation of cell morphogenesis involved in differentiation0.18130.008937Highly InformativeInherited
Biological Process (BP)negative regulation of cytoskeleton organization0.053670.000000004763Highly InformativeInherited
Biological Process (BP)negative regulation of supramolecular fiber organization0.0014050.000000001636Highly InformativeInherited
Biological Process (BP)phagocytosis0.00012630.8227Highly InformativeInherited
Biological Process (BP)protein localization to membrane0.0018440.0000004674Highly InformativeInherited
Biological Process (BP)leukocyte migration0.082890.02852Highly InformativeInherited
Biological Process (BP)microtubule cytoskeleton organization0.00010281Highly InformativeInherited
Molecular Function (MF)binding00Least InformativeDirect
Molecular Function (MF)hydrolase activity10.0004514Least InformativeInherited
Molecular Function (MF)metal ion binding00Moderately InformativeDirect
Molecular Function (MF)molecular function regulator0.000000000084740Moderately InformativeDirect
Molecular Function (MF)hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides11Moderately InformativeInherited
Molecular Function (MF)structural molecule activity0.017290.000000000005965Moderately InformativeInherited
Molecular Function (MF)transporter activity10.2815Moderately InformativeInherited
Molecular Function (MF)hydrolase activity, acting on ester bonds10.0000000000002864Moderately InformativeInherited
Molecular Function (MF)cytoskeletal protein binding00InformativeDirect
Molecular Function (MF)protein dimerization activity0.0007780.0000000000005076InformativeDirect
Molecular Function (MF)identical protein binding0.021230.000000000044InformativeInherited
Molecular Function (MF)receptor binding0.64081InformativeInherited
Molecular Function (MF)macromolecular complex binding0.00022580.009515InformativeInherited
Molecular Function (MF)ATPase activity0.51831InformativeInherited
Molecular Function (MF)enzyme activator activity0.0000074251InformativeInherited
Molecular Function (MF)metal ion transmembrane transporter activity0.090090.0000001208InformativeInherited
Molecular Function (MF)passive transmembrane transporter activity0.14060.0006498InformativeInherited
Molecular Function (MF)phosphatase activity11InformativeInherited
Molecular Function (MF)calcium ion binding00Highly InformativeDirect
Molecular Function (MF)protein homodimerization activity0.00074070.0000000000001272Highly InformativeDirect
Molecular Function (MF)actin filament binding0.00000012850.00000001767Highly InformativeDirect
Molecular Function (MF)ion channel activity0.0018990.01235Highly InformativeInherited
Molecular Function (MF)phosphoprotein phosphatase activity0.080660.0957Highly InformativeInherited
Cellular Component (CC)non-membrane-bounded organelle00Least InformativeDirect
Cellular Component (CC)intracellular organelle part0.0000063120.00000004027Least InformativeDirect
Cellular Component (CC)membrane0.18690Least InformativeInherited
Cellular Component (CC)macromolecular complex0.098481Least InformativeInherited
Cellular Component (CC)cytoplasmic part10Least InformativeInherited
Cellular Component (CC)cytoskeleton00Moderately InformativeDirect
Cellular Component (CC)cell projection00Moderately InformativeDirect
Cellular Component (CC)vesicle0.0022740.0000000001324Moderately InformativeInherited
Cellular Component (CC)extracellular region part0.12040.002423Moderately InformativeInherited
Cellular Component (CC)plasma membrane0.096940Moderately InformativeInherited
Cellular Component (CC)transferase complex11Moderately InformativeInherited
Cellular Component (CC)cilium0.00042190.00002698InformativeDirect
Cellular Component (CC)actin cytoskeleton0.0000000020410InformativeDirect
Cellular Component (CC)synapse0.000056930InformativeDirect
Cellular Component (CC)supramolecular polymer00InformativeDirect
Cellular Component (CC)cytoplasmic region0.000082040InformativeDirect
Cellular Component (CC)extracellular space0.1440.02032InformativeInherited
Cellular Component (CC)extracellular organelle0.045970.0002323InformativeInherited
Cellular Component (CC)ubiquitin ligase complex0.2531InformativeInherited
Cellular Component (CC)side of membrane0.0059520.9674InformativeInherited
Cellular Component (CC)extrinsic component of membrane0.001540.05151InformativeInherited
Cellular Component (CC)ruffle0.000000000034380.00009688Highly InformativeDirect
Cellular Component (CC)protein serine/threonine phosphatase complex0.00014030.0002209Highly InformativeDirect
Cellular Component (CC)sarcoplasm0.000000020510Highly InformativeDirect
Cellular Component (CC)lamellipodium0.0000000031390Highly InformativeDirect
Cellular Component (CC)extrinsic component of cytoplasmic side of plasma membrane0.0005280.0001387Highly InformativeDirect
Cellular Component (CC)sarcolemma0.0001030Highly InformativeDirect
Cellular Component (CC)contractile fiber part00Highly InformativeDirect
Cellular Component (CC)extracellular vesicle0.059260.03998Highly InformativeInherited
Cellular Component (CC)cortical actin cytoskeleton0.50510Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)