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EF-hand superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   EF Hand-like [ 47472] (4)
Superfamily:   EF-hand [ 47473] (11)
Families:   Calbindin D9K [ 47474]
  S100 proteins [ 47478]
  Polcalcin [ 89048] (3)
  Osteonectin [ 47489]
  Parvalbumin [ 47492] (2)
  Calmodulin-like [ 47502] (23)
  Eps15 homology domain (EH domain) [ 47543] (3)
  Cbp40 (plasmodial specific CaII-binding protein LAV1-2) [ 81758]
  Penta-EF-hand proteins [ 63550] (6)
  EF-hand modules in multidomain proteins [ 47547] (8)
  p25-alpha [ 140538] (2)


Superfamily statistics
Genomes (1,144) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 70,336 170,185 217
Proteins 62,203 150,401 215


Functional annotation
General category General
Detailed category General

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biological regulation0.0000000000044390.0000000002432Least InformativeDirect
Biological Process (BP)multicellular organismal process0.000000000035410Least InformativeDirect
Biological Process (BP)cellular component organization or biogenesis0.00000000068920Least InformativeDirect
Biological Process (BP)response to stimulus0.0000011120.0000000146Least InformativeDirect
Biological Process (BP)single-organism cellular process0.054220Least InformativeInherited
Biological Process (BP)single organism signaling0.00000000980.00004807Moderately InformativeDirect
Biological Process (BP)cell communication0.00000029960.000002631Moderately InformativeDirect
Biological Process (BP)regulation of molecular function0.000013510.00000001117Moderately InformativeDirect
Biological Process (BP)cellular localization0.000079470Moderately InformativeDirect
Biological Process (BP)regulation of localization0.00020780Moderately InformativeDirect
Biological Process (BP)organelle organization0.00067180.0000000007702Moderately InformativeDirect
Biological Process (BP)response to endogenous stimulus0.86951Moderately InformativeInherited
Biological Process (BP)response to organic substance0.83811Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.058221Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.0033840.6516Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.071080.02126Moderately InformativeInherited
Biological Process (BP)immune system process0.0000051020.3879Moderately InformativeInherited
Biological Process (BP)cellular component assembly0.27150Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.0071981Moderately InformativeInherited
Biological Process (BP)response to external stimulus10.945Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.00068430.006789Moderately InformativeInherited
Biological Process (BP)tissue development0.67070.00000001976Moderately InformativeInherited
Biological Process (BP)macromolecular complex subunit organization0.79370.7768Moderately InformativeInherited
Biological Process (BP)protein complex biogenesis0.0065060.1305Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process0.047821Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.84861Moderately InformativeInherited
Biological Process (BP)regulation of cell communication0.011080.00007414Moderately InformativeInherited
Biological Process (BP)regulation of signaling0.0062620.000003994Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process11Moderately InformativeInherited
Biological Process (BP)regulation of response to stimulus0.00092230.02241Moderately InformativeInherited
Biological Process (BP)animal organ development0.13870.000009307Moderately InformativeInherited
Biological Process (BP)single-organism transport0.81610.8825Moderately InformativeInherited
Biological Process (BP)cell differentiation0.0000029960.02086Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.011110.8801Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound11Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.091280.0000000004802Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.074750.0249Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.07721Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.081190.003232Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.024520.000611Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.062060.000000000001311Moderately InformativeInherited
Biological Process (BP)regulation of macromolecule biosynthetic process0.2991Moderately InformativeInherited
Biological Process (BP)defense response0.0035070.3531Moderately InformativeInherited
Biological Process (BP)microtubule-based process00InformativeDirect
Biological Process (BP)supramolecular fiber organization00InformativeDirect
Biological Process (BP)vesicle-mediated transport0.000000011480.000000199InformativeDirect
Biological Process (BP)regulation of response to external stimulus0.0000011790.000002766InformativeDirect
Biological Process (BP)cellular component morphogenesis0.000005120InformativeDirect
Biological Process (BP)regulation of transmembrane transport0.000032880InformativeDirect
Biological Process (BP)regulation of ion transport0.000070920.0000000000000376InformativeDirect
Biological Process (BP)positive regulation of cellular protein metabolic process0.000090860.00009129InformativeDirect
Biological Process (BP)cell development0.000093060InformativeDirect
Biological Process (BP)single-organism membrane organization0.00016610.0000000004926InformativeDirect
Biological Process (BP)anatomical structure formation involved in morphogenesis0.00029450InformativeDirect
Biological Process (BP)regulation of system process0.00033740.000366InformativeDirect
Biological Process (BP)positive regulation of signal transduction0.68551InformativeInherited
Biological Process (BP)regulation of apoptotic process0.00098841InformativeInherited
Biological Process (BP)positive regulation of immune system process0.0012880.2629InformativeInherited
Biological Process (BP)regulation of cell cycle0.061831InformativeInherited
Biological Process (BP)regulation of protein modification process0.57560.139InformativeInherited
Biological Process (BP)negative regulation of cellular component organization0.56930.001364InformativeInherited
Biological Process (BP)movement of cell or subcellular component0.0013110.0006939InformativeInherited
Biological Process (BP)localization of cell0.23641InformativeInherited
Biological Process (BP)regulation of peptide transport0.38161InformativeInherited
Biological Process (BP)intracellular transport0.69010.00002102InformativeInherited
Biological Process (BP)regulation of locomotion0.00003480.01014InformativeInherited
Biological Process (BP)single-organism cellular localization0.0049650.0003063InformativeInherited
Biological Process (BP)regulation of cellular component movement0.000015940.007229InformativeInherited
Biological Process (BP)locomotion0.0029330.0004519InformativeInherited
Biological Process (BP)response to organic cyclic compound0.97920.1995InformativeInherited
Biological Process (BP)response to nitrogen compound10.644InformativeInherited
Biological Process (BP)cellular response to oxygen-containing compound11InformativeInherited
Biological Process (BP)cellular response to inorganic substance0.58180.00000006978InformativeInherited
Biological Process (BP)actin cytoskeleton organization0.086540InformativeInherited
Biological Process (BP)regulation of proteolysis0.1780.00000001031InformativeInherited
Biological Process (BP)regulation of hydrolase activity0.30491InformativeInherited
Biological Process (BP)response to metal ion0.031240.00001267InformativeInherited
Biological Process (BP)cellular protein complex assembly0.00000082540.8563InformativeInherited
Biological Process (BP)negative regulation of signaling0.0085790.08755InformativeInherited
Biological Process (BP)negative regulation of cell communication0.017580.09111InformativeInherited
Biological Process (BP)negative regulation of response to stimulus0.20350.3228InformativeInherited
Biological Process (BP)regulation of intracellular signal transduction0.0021690.9071InformativeInherited
Biological Process (BP)animal organ morphogenesis0.42360.4783InformativeInherited
Biological Process (BP)embryo development0.91671InformativeInherited
Biological Process (BP)organelle localization0.030060.1563InformativeInherited
Biological Process (BP)immune effector process0.92280.05969InformativeInherited
Biological Process (BP)secretion by cell0.00031940.03862InformativeInherited
Biological Process (BP)regulation of cell proliferation0.003060.9938InformativeInherited
Biological Process (BP)response to radiation0.71311InformativeInherited
Biological Process (BP)immune response0.00090070.5557InformativeInherited
Biological Process (BP)regulation of protein localization11InformativeInherited
Biological Process (BP)regulation of cellular localization0.34750.2986InformativeInherited
Biological Process (BP)positive regulation of transport0.018580.0006573InformativeInherited
Biological Process (BP)regulation of organelle organization10.8966InformativeInherited
Biological Process (BP)regulation of cell differentiation0.056410.01466InformativeInherited
Biological Process (BP)positive regulation of multicellular organismal process0.57750.1195InformativeInherited
Biological Process (BP)positive regulation of nucleobase-containing compound metabolic process0.2781InformativeInherited
Biological Process (BP)positive regulation of phosphate metabolic process0.53160.9332InformativeInherited
Biological Process (BP)intracellular signal transduction0.022080.4872InformativeInherited
Biological Process (BP)regulation of nervous system development0.033060.00194InformativeInherited
Biological Process (BP)generation of neurons0.77270.1088InformativeInherited
Biological Process (BP)positive regulation of developmental process0.38580.0000001664InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis0.14450.108InformativeInherited
Biological Process (BP)positive regulation of cellular component organization10.1375InformativeInherited
Biological Process (BP)positive regulation of cellular biosynthetic process0.057711InformativeInherited
Biological Process (BP)positive regulation of macromolecule biosynthetic process0.23761InformativeInherited
Biological Process (BP)system process0.0000000041490.02625InformativeInherited
Biological Process (BP)cell activation0.00012060.003234InformativeInherited
Biological Process (BP)inflammatory response0.00000000000019790.000004619Highly InformativeDirect
Biological Process (BP)positive regulation of response to external stimulus0.0000000000024320.0002068Highly InformativeDirect
Biological Process (BP)protein polymerization0.00000000018050.000000000676Highly InformativeDirect
Biological Process (BP)plasma membrane bounded cell projection organization0.00000000019990.0001024Highly InformativeDirect
Biological Process (BP)cellular component assembly involved in morphogenesis0.0000000048740Highly InformativeDirect
Biological Process (BP)striated muscle cell development0.000000010010.0000000000005513Highly InformativeDirect
Biological Process (BP)muscle system process0.000000015080Highly InformativeDirect
Biological Process (BP)regulation of mitotic cell cycle phase transition0.000000020240.0004334Highly InformativeDirect
Biological Process (BP)muscle tissue development0.00000010640Highly InformativeDirect
Biological Process (BP)positive regulation of transporter activity0.00000011760.000000000001735Highly InformativeDirect
Biological Process (BP)regulation of intracellular protein transport0.00000032420.0004222Highly InformativeDirect
Biological Process (BP)positive regulation of mitotic cell cycle0.0000011160.0001491Highly InformativeDirect
Biological Process (BP)regulation of leukocyte migration0.000001170.0000002908Highly InformativeDirect
Biological Process (BP)regulation of smooth muscle cell proliferation0.0000017390.0001078Highly InformativeDirect
Biological Process (BP)regulation of calcium-mediated signaling0.0000030810.0000000001838Highly InformativeDirect
Biological Process (BP)positive regulation of transmembrane transport0.0000033450.000000000003257Highly InformativeDirect
Biological Process (BP)cellular response to calcium ion0.0000056820.00000000000002102Highly InformativeDirect
Biological Process (BP)regulation of neuron projection development0.0000093790.00000001426Highly InformativeDirect
Biological Process (BP)heart contraction0.000018540.0000000878Highly InformativeDirect
Biological Process (BP)establishment of organelle localization0.000028510.000000187Highly InformativeDirect
Biological Process (BP)leukocyte degranulation0.000044450.00009953Highly InformativeDirect
Biological Process (BP)positive regulation of proteolysis0.000067450.000001646Highly InformativeDirect
Biological Process (BP)positive regulation of leukocyte proliferation0.00016670.0009798Highly InformativeDirect
Biological Process (BP)regulation of protein import0.00021240.00006892Highly InformativeDirect
Biological Process (BP)regulation of protein modification by small protein conjugation or removal0.00065890.000000000004524Highly InformativeDirect
Biological Process (BP)positive regulation of ion transport0.00093790.000003076Highly InformativeDirect
Biological Process (BP)muscle organ development0.00094670Highly InformativeDirect
Biological Process (BP)positive regulation of apoptotic process0.0015781Highly InformativeInherited
Biological Process (BP)regulation of apoptotic signaling pathway0.0019160.4088Highly InformativeInherited
Biological Process (BP)positive regulation of cell migration0.000000000000083520.007162Highly InformativeInherited
Biological Process (BP)response to growth factor0.25730.6873Highly InformativeInherited
Biological Process (BP)regulation of protein complex disassembly0.093980.0000000000001924Highly InformativeInherited
Biological Process (BP)positive regulation of cell cycle process0.0011760.001154Highly InformativeInherited
Biological Process (BP)leukocyte migration0.060080.02637Highly InformativeInherited
Biological Process (BP)cell projection assembly0.0000039820.4951Highly InformativeInherited
Biological Process (BP)positive regulation of cellular protein localization0.00015010.01859Highly InformativeInherited
Biological Process (BP)positive regulation of intracellular transport0.00067480.0151Highly InformativeInherited
Biological Process (BP)positive regulation of protein transport0.011031Highly InformativeInherited
Biological Process (BP)vesicle organization0.43250.7153Highly InformativeInherited
Biological Process (BP)protein localization to membrane0.0021410.000001251Highly InformativeInherited
Biological Process (BP)cellular response to abiotic stimulus0.36890.1647Highly InformativeInherited
Biological Process (BP)response to purine-containing compound0.0096520Highly InformativeInherited
Biological Process (BP)cellular response to organonitrogen compound0.4990.01776Highly InformativeInherited
Biological Process (BP)biological adhesion0.0000065210.8715Highly InformativeInherited
Biological Process (BP)actin filament organization0.92271Highly InformativeInherited
Biological Process (BP)positive regulation of sequence-specific DNA binding transcription factor activity0.0065940.0000002429Highly InformativeInherited
Biological Process (BP)positive regulation of lymphocyte activation0.00000000095110.007786Highly InformativeInherited
Biological Process (BP)positive regulation of cell adhesion0.00000020220.006113Highly InformativeInherited
Biological Process (BP)negative regulation of intracellular signal transduction0.00064850.7464Highly InformativeInherited
Biological Process (BP)sensory organ morphogenesis0.064681Highly InformativeInherited
Biological Process (BP)tube morphogenesis0.45260.000383Highly InformativeInherited
Biological Process (BP)embryonic organ development0.7520.9392Highly InformativeInherited
Biological Process (BP)Golgi vesicle transport10.8495Highly InformativeInherited
Biological Process (BP)regulation of T cell activation0.0000000019390.006989Highly InformativeInherited
Biological Process (BP)regulation of lymphocyte proliferation0.0000000030480.001585Highly InformativeInherited
Biological Process (BP)cell morphogenesis involved in differentiation0.18631Highly InformativeInherited
Biological Process (BP)innate immune response0.00020220.7457Highly InformativeInherited
Biological Process (BP)response to organophosphorus0.050470.00000000001307Highly InformativeInherited
Biological Process (BP)regulation of cation transmembrane transport0.000000000069740.002668Highly InformativeInherited
Biological Process (BP)regulation of transmembrane transporter activity0.000065170.5012Highly InformativeInherited
Biological Process (BP)regulation of hemopoiesis0.030960.8736Highly InformativeInherited
Biological Process (BP)positive regulation of nucleotide metabolic process0.019010.1792Highly InformativeInherited
Biological Process (BP)regulation of cyclic nucleotide metabolic process0.000032070.3617Highly InformativeInherited
Biological Process (BP)cell chemotaxis0.0012610.07651Highly InformativeInherited
Biological Process (BP)regulation of G-protein coupled receptor protein signaling pathway0.029620.000181Highly InformativeInherited
Biological Process (BP)second-messenger-mediated signaling0.0029430.0004925Highly InformativeInherited
Biological Process (BP)small GTPase mediated signal transduction0.019780.0002919Highly InformativeInherited
Biological Process (BP)regulation of cell morphogenesis involved in differentiation0.17880.001986Highly InformativeInherited
Biological Process (BP)positive regulation of cell development0.33270.0002213Highly InformativeInherited
Biological Process (BP)regulation of microtubule-based process0.0032650.0000000000002241Highly InformativeInherited
Biological Process (BP)negative regulation of cytoskeleton organization0.068450.000000000005512Highly InformativeInherited
Biological Process (BP)negative regulation of supramolecular fiber organization0.0020920.0000000000007186Highly InformativeInherited
Biological Process (BP)endomembrane system organization0.0032690.04253Highly InformativeInherited
Biological Process (BP)phagocytosis0.0000022110.7431Highly InformativeInherited
Biological Process (BP)microtubule cytoskeleton organization0.000048811Highly InformativeInherited
Molecular Function (MF)binding00Least InformativeDirect
Molecular Function (MF)hydrolase activity10.0000197Least InformativeInherited
Molecular Function (MF)metal ion binding00Moderately InformativeDirect
Molecular Function (MF)molecular function regulator0.000000000031060Moderately InformativeDirect
Molecular Function (MF)hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides11Moderately InformativeInherited
Molecular Function (MF)structural molecule activity0.023090.000000000003824Moderately InformativeInherited
Molecular Function (MF)transporter activity10.3753Moderately InformativeInherited
Molecular Function (MF)hydrolase activity, acting on ester bonds10Moderately InformativeInherited
Molecular Function (MF)cytoskeletal protein binding00InformativeDirect
Molecular Function (MF)protein dimerization activity0.00084550.000000000000001615InformativeDirect
Molecular Function (MF)receptor binding0.57211InformativeInherited
Molecular Function (MF)identical protein binding0.019650.0000000000001823InformativeInherited
Molecular Function (MF)macromolecular complex binding0.0005130.005019InformativeInherited
Molecular Function (MF)ATPase activity0.56241InformativeInherited
Molecular Function (MF)enzyme activator activity0.0000019891InformativeInherited
Molecular Function (MF)metal ion transmembrane transporter activity0.10030.0000003959InformativeInherited
Molecular Function (MF)passive transmembrane transporter activity0.15810.0008774InformativeInherited
Molecular Function (MF)phosphatase activity0.98261InformativeInherited
Molecular Function (MF)calcium ion binding00Highly InformativeDirect
Molecular Function (MF)actin filament binding0.0000015520.00000001913Highly InformativeDirect
Molecular Function (MF)protein homodimerization activity0.00070850Highly InformativeDirect
Molecular Function (MF)ion channel activity0.0018670.01551Highly InformativeInherited
Molecular Function (MF)phosphoprotein phosphatase activity0.036710.07421Highly InformativeInherited
Cellular Component (CC)non-membrane-bounded organelle00Least InformativeDirect
Cellular Component (CC)protein complex0.000029730.0006231Least InformativeDirect
Cellular Component (CC)intracellular organelle part0.000053720.000000006323Least InformativeDirect
Cellular Component (CC)cytoplasmic part10Least InformativeInherited
Cellular Component (CC)membrane0.31680Least InformativeInherited
Cellular Component (CC)cell projection00Moderately InformativeDirect
Cellular Component (CC)cytoskeleton00Moderately InformativeDirect
Cellular Component (CC)vesicle0.0024530.0000000002666Moderately InformativeInherited
Cellular Component (CC)extracellular region part0.18250.005639Moderately InformativeInherited
Cellular Component (CC)transferase complex11Moderately InformativeInherited
Cellular Component (CC)plasma membrane0.20190Moderately InformativeInherited
Cellular Component (CC)supramolecular polymer00InformativeDirect
Cellular Component (CC)actin cytoskeleton0.000000012750InformativeDirect
Cellular Component (CC)cytoplasmic region0.000036450InformativeDirect
Cellular Component (CC)cilium0.00048310.00001728InformativeDirect
Cellular Component (CC)side of membrane0.0073631InformativeInherited
Cellular Component (CC)extracellular organelle0.057420.0005081InformativeInherited
Cellular Component (CC)extracellular space0.10340.01261InformativeInherited
Cellular Component (CC)ubiquitin ligase complex0.27461InformativeInherited
Cellular Component (CC)extrinsic component of membrane0.0013830.05222InformativeInherited
Cellular Component (CC)ruffle0.000000000091370.0003872Highly InformativeDirect
Cellular Component (CC)sarcoplasm0.0000000038460Highly InformativeDirect
Cellular Component (CC)lamellipodium0.000000019720Highly InformativeDirect
Cellular Component (CC)protein serine/threonine phosphatase complex0.000026040.00008648Highly InformativeDirect
Cellular Component (CC)contractile ring0.00028860.00006883Highly InformativeDirect
Cellular Component (CC)cell division site part0.00043940.0003652Highly InformativeDirect
Cellular Component (CC)extracellular exosome0.00053310.0001106Highly InformativeDirect
Cellular Component (CC)extrinsic component of cytoplasmic side of plasma membrane0.0005920.0001725Highly InformativeDirect
Cellular Component (CC)basal part of cell0.00060550.0006055Highly InformativeDirect
Cellular Component (CC)cortical cytoskeleton0.48930Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)