SUPERFAMILY 1.75 HMM library and genome assignments server

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EF-hand superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   EF Hand-like [ 47472] (4)
Superfamily:   EF-hand [ 47473] (11)
Families:   Calbindin D9K [ 47474]
  S100 proteins [ 47478]
  Polcalcin [ 89048] (3)
  Osteonectin [ 47489]
  Parvalbumin [ 47492] (2)
  Calmodulin-like [ 47502] (23)
  Eps15 homology domain (EH domain) [ 47543] (3)
  Cbp40 (plasmodial specific CaII-binding protein LAV1-2) [ 81758]
  Penta-EF-hand proteins [ 63550] (6)
  EF-hand modules in multidomain proteins [ 47547] (8)
  p25-alpha [ 140538] (2)


Superfamily statistics
Genomes (1,135) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 67,240 81,218 217
Proteins 59,403 72,530 215


Functional annotation
General category General
Detailed category General

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process0.00000000000010120.0000000000001174Least InformativeDirect
Biological Process (BP)developmental process0.00000061380.000000001012Least InformativeDirect
Biological Process (BP)single-organism cellular process00Least InformativeDirect
Biological Process (BP)response to stimulus0.00000000013310Least InformativeDirect
Biological Process (BP)localization0.00000001520Least InformativeDirect
Biological Process (BP)cellular component organization or biogenesis00.00000000008187Least InformativeDirect
Biological Process (BP)regulation of cellular process0.087040.0003672Least InformativeInherited
Biological Process (BP)regulation of metabolic process11Least InformativeInherited
Biological Process (BP)system process0.0000094320.00002197Moderately InformativeDirect
Biological Process (BP)signal transduction0.00021530.0000002666Moderately InformativeDirect
Biological Process (BP)regulation of catalytic activity0.00000000093070Moderately InformativeDirect
Biological Process (BP)response to endogenous stimulus0.84850.1681Moderately InformativeInherited
Biological Process (BP)response to organic substance0.84521Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.037670.6998Moderately InformativeInherited
Biological Process (BP)cellular component biogenesis0.27970.008713Moderately InformativeInherited
Biological Process (BP)organelle organization0.00000044870.004993Moderately InformativeInherited
Biological Process (BP)positive regulation of response to stimulus0.00072490.2127Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.39390.006677Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.20051Moderately InformativeInherited
Biological Process (BP)tissue development0.021310.02446Moderately InformativeInherited
Biological Process (BP)cellular localization0.010740Moderately InformativeInherited
Biological Process (BP)positive regulation of molecular function0.000020340.05163Moderately InformativeInherited
Biological Process (BP)regulation of macromolecule biosynthetic process0.55391Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.047611Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.0012731Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process0.00030921Moderately InformativeInherited
Biological Process (BP)macromolecular complex subunit organization0.11910.001383Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.13290.000000006038Moderately InformativeInherited
Biological Process (BP)single-organism developmental process0.85860.7369Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process11Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.97350.05133Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process0.8781Moderately InformativeInherited
Biological Process (BP)regulation of phosphate metabolic process10.0000009685Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.0075930.02303Moderately InformativeInherited
Biological Process (BP)ion transport10.05007Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.0013640.3033Moderately InformativeInherited
Biological Process (BP)organic substance transport0.94241Moderately InformativeInherited
Biological Process (BP)regulation of localization0.0018870.00000001775Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.47920.005666Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.045410.06092Moderately InformativeInherited
Biological Process (BP)cell differentiation0.054720.3568Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.1320.003854Moderately InformativeInherited
Biological Process (BP)nervous system development0.89860.7214Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.04040.0001615Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.80361Moderately InformativeInherited
Biological Process (BP)multi-organism process0.34480.5777Moderately InformativeInherited
Biological Process (BP)immune system process0.000000028850.06255Moderately InformativeInherited
Biological Process (BP)muscle system process0.0000000053370InformativeDirect
Biological Process (BP)cellular component movement0.000027320.0000000004408InformativeDirect
Biological Process (BP)cytoskeleton organization00InformativeDirect
Biological Process (BP)microtubule-based process0.0000000023660.00000000000001604InformativeDirect
Biological Process (BP)response to wounding0.000000085610.0000002253InformativeDirect
Biological Process (BP)protein transport0.00000067320.000002727InformativeDirect
Biological Process (BP)cellular membrane organization0.0000010410.0000000006772InformativeDirect
Biological Process (BP)metal ion transport0.00078420.000002168InformativeDirect
Biological Process (BP)actin filament-based process00InformativeDirect
Biological Process (BP)regulation of response to external stimulus0.00000002120.000000125InformativeDirect
Biological Process (BP)regulation of intracellular transport0.00061950.000007046InformativeDirect
Biological Process (BP)cellular component morphogenesis0.0000031540.00003027InformativeDirect
Biological Process (BP)intracellular signal transduction0.000016130.0001866InformativeDirect
Biological Process (BP)anatomical structure formation involved in morphogenesis0.00027880.000000000001185InformativeDirect
Biological Process (BP)positive regulation of transport0.00091960.000006243InformativeDirect
Biological Process (BP)muscle tissue development0.00000010130.000000008492InformativeDirect
Biological Process (BP)muscle structure development0.00000000035420InformativeDirect
Biological Process (BP)organelle assembly0.00049850.000000001863InformativeDirect
Biological Process (BP)regulation of purine nucleotide metabolic process0.00000067430.00005605InformativeDirect
Biological Process (BP)regulation of apoptotic process0.82631InformativeInherited
Biological Process (BP)positive regulation of signal transduction0.25981InformativeInherited
Biological Process (BP)regulation of ion transport0.0016610.0000000002144InformativeInherited
Biological Process (BP)positive regulation of immune system process0.22380.6295InformativeInherited
Biological Process (BP)regulation of cellular component movement0.00002550.02664InformativeInherited
Biological Process (BP)regulation of locomotion0.000060580.02768InformativeInherited
Biological Process (BP)cellular response to endogenous stimulus0.39890.7821InformativeInherited
Biological Process (BP)regulation of cell cycle process0.002760.2589InformativeInherited
Biological Process (BP)negative regulation of cellular component organization0.71060.003054InformativeInherited
Biological Process (BP)regulation of mitotic cell cycle0.025660.09786InformativeInherited
Biological Process (BP)regulation of peptidase activity0.22390.08202InformativeInherited
Biological Process (BP)positive regulation of hydrolase activity0.27930.8194InformativeInherited
Biological Process (BP)regulation of establishment of protein localization0.042760.136InformativeInherited
Biological Process (BP)regulation of cell proliferation0.016360.9553InformativeInherited
Biological Process (BP)transmembrane transport10.9684InformativeInherited
Biological Process (BP)biological adhesion0.000051020.9239InformativeInherited
Biological Process (BP)blood circulation0.00000000000021480.7582InformativeInherited
Biological Process (BP)regulation of intracellular protein kinase cascade0.54780.5792InformativeInherited
Biological Process (BP)organelle localization0.10840.003535InformativeInherited
Biological Process (BP)response to inorganic substance0.0096330.00000002487InformativeInherited
Biological Process (BP)cellular macromolecular complex assembly0.013761InformativeInherited
Biological Process (BP)vesicle-mediated transport0.026350.1182InformativeInherited
Biological Process (BP)immune effector process10.791InformativeInherited
Biological Process (BP)secretion by cell0.11360.0005256InformativeInherited
Biological Process (BP)cell projection organization0.0014130.8965InformativeInherited
Biological Process (BP)negative regulation of protein metabolic process0.01970.0000127InformativeInherited
Biological Process (BP)regulation of organelle organization0.64430.2743InformativeInherited
Biological Process (BP)positive regulation of developmental process0.3060.000000311InformativeInherited
Biological Process (BP)locomotion0.0000027120.002805InformativeInherited
Biological Process (BP)localization of cell0.012571InformativeInherited
Biological Process (BP)generation of neurons0.025380.2834InformativeInherited
Biological Process (BP)regulation of nervous system development0.21910.14InformativeInherited
Biological Process (BP)regulation of cell development0.40570.000002211InformativeInherited
Biological Process (BP)positive regulation of macromolecule biosynthetic process0.093871InformativeInherited
Biological Process (BP)positive regulation of cellular biosynthetic process0.35371InformativeInherited
Biological Process (BP)immune response0.0039340.324InformativeInherited
Biological Process (BP)defense response0.012020.0007768InformativeInherited
Biological Process (BP)response to other organism0.22950.0173InformativeInherited
Biological Process (BP)response to light stimulus0.00440.07558InformativeInherited
Biological Process (BP)leukocyte activation0.83450.882InformativeInherited
Biological Process (BP)myeloid leukocyte activation0.000099640.0002832Highly InformativeDirect
Biological Process (BP)inflammatory response0.0000000010470.0009492Highly InformativeDirect
Biological Process (BP)detection of light stimulus0.00000014220.00000001349Highly InformativeDirect
Biological Process (BP)cellular component assembly involved in morphogenesis0.0000000011310.0000000000000126Highly InformativeDirect
Biological Process (BP)regulation of neuron projection development0.0001030.00000001969Highly InformativeDirect
Biological Process (BP)actin filament-based movement0.00000019850.000000000000895Highly InformativeDirect
Biological Process (BP)actomyosin structure organization0.0000023090.000000009884Highly InformativeDirect
Biological Process (BP)negative regulation of protein modification process0.00081420.00000003014Highly InformativeDirect
Biological Process (BP)positive regulation of response to external stimulus0.00000000000094170.0002314Highly InformativeDirect
Biological Process (BP)positive regulation of intracellular transport0.000010050.000000549Highly InformativeDirect
Biological Process (BP)regulation of transporter activity0.00000043440Highly InformativeDirect
Biological Process (BP)regulation of mononuclear cell proliferation0.000000016170.0007355Highly InformativeDirect
Biological Process (BP)regulation of transmembrane transport0.0000053920.00000000000001083Highly InformativeDirect
Biological Process (BP)regulation of smooth muscle cell proliferation0.0000026310.0001809Highly InformativeDirect
Biological Process (BP)regulation of calcium-mediated signaling0.00000250.0007668Highly InformativeDirect
Biological Process (BP)positive regulation of cell activation0.000056140.0000000000451Highly InformativeDirect
Biological Process (BP)protein polymerization0.00000000023160.000000002361Highly InformativeDirect
Biological Process (BP)response to calcium ion0.000000000056150Highly InformativeDirect
Biological Process (BP)regulation of protein kinase B signaling cascade0.000068010.0007536Highly InformativeDirect
Biological Process (BP)heart contraction0.00060880.000000004371Highly InformativeDirect
Biological Process (BP)positive regulation of leukocyte proliferation0.000120.0007345Highly InformativeDirect
Biological Process (BP)regulation of G1/S transition of mitotic cell cycle0.000000000074420.000000001279Highly InformativeDirect
Biological Process (BP)regulation of intrinsic apoptotic signaling pathway0.0000009770.0001283Highly InformativeDirect
Biological Process (BP)positive regulation of apoptotic signaling pathway0.00074940.1095Highly InformativeInherited
Biological Process (BP)regulation of lymphocyte migration0.014570.004175Highly InformativeInherited
Biological Process (BP)positive regulation of cell migration0.0000000000000063810.001465Highly InformativeInherited
Biological Process (BP)cellular response to growth factor stimulus0.59811Highly InformativeInherited
Biological Process (BP)positive regulation of cell cycle process0.00010850.02796Highly InformativeInherited
Biological Process (BP)regulation of protein complex disassembly0.045650.00000000009286Highly InformativeInherited
Biological Process (BP)positive regulation of endopeptidase activity0.000000001160.4264Highly InformativeInherited
Biological Process (BP)cell projection assembly0.00037940.1563Highly InformativeInherited
Biological Process (BP)regulation of intracellular protein transport0.0000011510.06166Highly InformativeInherited
Biological Process (BP)calcium ion transport0.41730.0004611Highly InformativeInherited
Biological Process (BP)cell adhesion0.011881Highly InformativeInherited
Biological Process (BP)positive regulation of sequence-specific DNA binding transcription factor activity0.17170.0005347Highly InformativeInherited
Biological Process (BP)actin filament organization0.00065360.2178Highly InformativeInherited
Biological Process (BP)regulation of behavior0.0000015720.07903Highly InformativeInherited
Biological Process (BP)leukocyte mediated immunity0.57720.1812Highly InformativeInherited
Biological Process (BP)leukocyte activation involved in immune response0.12620.0001949Highly InformativeInherited
Biological Process (BP)exocytosis0.26540.3099Highly InformativeInherited
Biological Process (BP)cell fate commitment0.0050160.09094Highly InformativeInherited
Biological Process (BP)regulation of T cell activation0.000000016170.01882Highly InformativeInherited
Biological Process (BP)regulation of proton transport0.0000073270.001137Highly InformativeInherited
Biological Process (BP)regulation of cyclic nucleotide metabolic process0.000000091560.00125Highly InformativeInherited
Biological Process (BP)regulation of myeloid cell differentiation0.0013040.4691Highly InformativeInherited
Biological Process (BP)regulation of leukocyte differentiation0.12081Highly InformativeInherited
Biological Process (BP)chemotaxis0.014670.3981Highly InformativeInherited
Biological Process (BP)regulation of G-protein coupled receptor protein signaling pathway0.059930.003783Highly InformativeInherited
Biological Process (BP)small GTPase mediated signal transduction0.11880.0005624Highly InformativeInherited
Biological Process (BP)G-protein coupled receptor signaling pathway0.33090.8862Highly InformativeInherited
Biological Process (BP)cellular response to radiation0.03440.3397Highly InformativeInherited
Biological Process (BP)innate immune response0.010510.819Highly InformativeInherited
Biological Process (BP)regulation of microtubule polymerization or depolymerization0.37430.00000007048Highly InformativeInherited
Biological Process (BP)negative regulation of cytoskeleton organization0.08190.0000000385Highly InformativeInherited
Biological Process (BP)phagocytosis0.001651Highly InformativeInherited
Biological Process (BP)leukocyte migration0.00069280.04088Highly InformativeInherited
Molecular Function (MF)binding00Least InformativeDirect
Molecular Function (MF)hydrolase activity10.02641Least InformativeInherited
Molecular Function (MF)enzyme regulator activity0.0000000093170Moderately InformativeDirect
Molecular Function (MF)cation binding00Moderately InformativeDirect
Molecular Function (MF)hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides0.93431Moderately InformativeInherited
Molecular Function (MF)transporter activity10.2393Moderately InformativeInherited
Molecular Function (MF)structural molecule activity0.0011630.000000000003095Moderately InformativeInherited
Molecular Function (MF)hydrolase activity, acting on ester bonds10.06913Moderately InformativeInherited
Molecular Function (MF)cytoskeletal protein binding00InformativeDirect
Molecular Function (MF)inorganic cation transmembrane transporter activity0.46350.1881InformativeInherited
Molecular Function (MF)receptor binding0.25951InformativeInherited
Molecular Function (MF)nucleoside-triphosphatase activity0.76431InformativeInherited
Molecular Function (MF)metal ion transmembrane transporter activity0.038820.00005984InformativeInherited
Molecular Function (MF)enzyme activator activity0.000063880.8195InformativeInherited
Molecular Function (MF)phosphoric ester hydrolase activity0.99370.0000000001558InformativeInherited
Molecular Function (MF)cation channel activity0.00049620.00000007216Highly InformativeDirect
Molecular Function (MF)calcium ion binding00Highly InformativeDirect
Molecular Function (MF)calcium ion transmembrane transporter activity0.000033990.000000001041Highly InformativeDirect
Molecular Function (MF)phosphatase regulator activity0.000015140.0001877Highly InformativeDirect
Molecular Function (MF)protein complex binding0.0015360.1974Highly InformativeInherited
Molecular Function (MF)phosphoprotein phosphatase activity0.06260.1334Highly InformativeInherited
Cellular Component (CC)intracellular non-membrane-bounded organelle00Least InformativeDirect
Cellular Component (CC)protein complex00.000000000003975Least InformativeDirect
Cellular Component (CC)intracellular organelle part0.000021380.01254Least InformativeInherited
Cellular Component (CC)cytoplasmic part10Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)membrane0.014950Least InformativeInherited
Cellular Component (CC)cytoskeleton00Moderately InformativeDirect
Cellular Component (CC)cell projection00Moderately InformativeDirect
Cellular Component (CC)endoplasmic reticulum0.0051620.00000001976Moderately InformativeInherited
Cellular Component (CC)plasma membrane0.037550Moderately InformativeInherited
Cellular Component (CC)actin cytoskeleton0.0000029210.000000000000003092InformativeDirect
Cellular Component (CC)cell leading edge00InformativeDirect
Cellular Component (CC)contractile fiber part00InformativeDirect
Cellular Component (CC)lytic vacuole0.95181InformativeInherited
Cellular Component (CC)microtubule cytoskeleton11InformativeInherited
Cellular Component (CC)protein serine/threonine phosphatase complex0.000024750.00007148Highly InformativeDirect
Cellular Component (CC)sarcoplasmic reticulum0.00093250.0000006579Highly InformativeDirect
Cellular Component (CC)cell division site part0.00036940.00005636Highly InformativeDirect
Cellular Component (CC)cilium part0.00020030.0001408Highly InformativeDirect
Cellular Component (CC)lysosome0.53340.9761Highly InformativeInherited
Cellular Component (CC)centrosome0.0000014050.002291Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)