SUPERFAMILY 1.75 HMM library and genome assignments server


Calponin-homology domain, CH-domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   CH domain-like [ 47575] (3)
Superfamily:   Calponin-homology domain, CH-domain [ 47576]
Families:   Calponin-homology domain, CH-domain [ 47577] (9)


Superfamily statistics
Genomes (500) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 12,471 13,257 21
Proteins 12,220 13,060 21


Functional annotation
General category General
Detailed category General

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)localization0.11870Least InformativeInherited
Biological Process (BP)single-organism cellular process0.018490Least InformativeInherited
Biological Process (BP)multicellular organismal process0.058830Least InformativeInherited
Biological Process (BP)macromolecule localization0.0012129.165e-07Moderately InformativeInherited
Biological Process (BP)system process0.022061Moderately InformativeInherited
Biological Process (BP)muscle system process0.00066290.0004633InformativeDirect
Biological Process (BP)establishment or maintenance of cell polarity0.00015891.599e-09Highly InformativeDirect
Molecular Function (MF)binding8.231e-060Least InformativeDirect
Molecular Function (MF)cytoskeletal protein binding8.375e-140InformativeDirect
Cellular Component (CC)intracellular non-membrane-bounded organelle2.986e-060Least InformativeDirect
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.081289.108e-10Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)cell projection0.00039330Moderately InformativeDirect
Cellular Component (CC)cytoskeleton0.00071030Moderately InformativeDirect
Cellular Component (CC)endomembrane system0.051090.03489Moderately InformativeInherited
Cellular Component (CC)organelle envelope0.15450.02916Moderately InformativeInherited
Cellular Component (CC)nuclear part0.53641Moderately InformativeInherited
Cellular Component (CC)contractile fiber part3.447e-090InformativeDirect
Cellular Component (CC)cell cortex1.807e-070InformativeDirect
Cellular Component (CC)nuclear envelope0.00012580InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.06234 Least Informative Inherited
Biological Process (BP) response to stimulus 0.00551 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) macromolecule localization 9.165e-07 Moderately Informative Direct
Biological Process (BP) cellular localization 0 Moderately Informative Direct
Biological Process (BP) organelle organization 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 1.477e-08 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 9.892e-06 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 9.371e-05 Moderately Informative Direct
Biological Process (BP) reproduction 0.0004277 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.2443 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.4482 Moderately Informative Inherited
Biological Process (BP) tissue development 0.02599 Moderately Informative Inherited
Biological Process (BP) immune system process 0.1155 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.1595 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.001753 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.7729 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.2429 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.002098 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.1302 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.7366 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.5254 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.1234 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.1168 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.5714 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.722 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.02844 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.946 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.002726 Moderately Informative Inherited
Biological Process (BP) muscle system process 0.0004633 Informative Direct
Biological Process (BP) cellular membrane organization 8.025e-08 Informative Direct
Biological Process (BP) cellular component movement 0 Informative Direct
Biological Process (BP) cytoskeleton organization 0 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0 Informative Direct
Biological Process (BP) microtubule-based process 0 Informative Direct
Biological Process (BP) actin filament-based process 0 Informative Direct
Biological Process (BP) regulation of organelle organization 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) cell projection organization 0 Informative Direct
Biological Process (BP) muscle structure development 1.198e-12 Informative Direct
Biological Process (BP) regulation of anatomical structure size 3.123e-12 Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 2.343e-11 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 8.022e-11 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 2.081e-09 Informative Direct
Biological Process (BP) regulation of growth 1.913e-08 Informative Direct
Biological Process (BP) vesicle-mediated transport 1.846e-07 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 4.84e-07 Informative Direct
Biological Process (BP) biological adhesion 7.807e-06 Informative Direct
Biological Process (BP) response to wounding 7.483e-05 Informative Direct
Biological Process (BP) localization of cell 7.725e-05 Informative Direct
Biological Process (BP) cell cycle process 0.0001391 Informative Direct
Biological Process (BP) generation of neurons 0.0001448 Informative Direct
Biological Process (BP) regulation of nervous system development 0.0008806 Informative Direct
Biological Process (BP) cellular response to endogenous stimulus 0.2247 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.7263 Informative Inherited
Biological Process (BP) protein localization to organelle 0.1778 Informative Inherited
Biological Process (BP) epithelium development 0.8669 Informative Inherited
Biological Process (BP) cardiovascular system development 1 Informative Inherited
Biological Process (BP) regulation of system process 0.6599 Informative Inherited
Biological Process (BP) organ morphogenesis 0.476 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.001339 Informative Inherited
Biological Process (BP) organelle localization 0.04272 Informative Inherited
Biological Process (BP) organelle assembly 0.5861 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.0239 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.01245 Informative Inherited
Biological Process (BP) regulation of cell development 0.009179 Informative Inherited
Biological Process (BP) negative regulation of transport 0.06705 Informative Inherited
Biological Process (BP) regulation of vesicle-mediated transport 0.559 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.1883 Informative Inherited
Biological Process (BP) positive regulation of transport 0.9472 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.002771 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.9267 Informative Inherited
Biological Process (BP) sensory organ development 0.2473 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.1335 Informative Inherited
Biological Process (BP) regulation of protein localization 0.8235 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.3527 Informative Inherited
Biological Process (BP) leukocyte activation 0.03045 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.1903 Informative Inherited
Biological Process (BP) tube development 0.1325 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.01175 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.2809 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.002331 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) reproductive system development 1 Informative Inherited
Biological Process (BP) response to nutrient levels 0.01359 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.09178 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.6901 Informative Inherited
Biological Process (BP) central nervous system development 0.01419 Informative Inherited
Biological Process (BP) muscle tissue development 0.7692 Informative Inherited
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of gene expression 1 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 1 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 1 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.01033 Informative Inherited
Biological Process (BP) single-organism behavior 0.1684 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.003155 Informative Inherited
Biological Process (BP) sexual reproduction 0.08985 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.6397 Informative Inherited
Biological Process (BP) single organism reproductive process 0.7093 Informative Inherited
Biological Process (BP) protein transport 0.007013 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.9476 Informative Inherited
Biological Process (BP) phosphorylation 1 Informative Inherited
Biological Process (BP) regulation of ion transport 0.145 Informative Inherited
Biological Process (BP) blood circulation 0.001758 Informative Inherited
Biological Process (BP) embryonic organ development 1 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.5024 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.52 Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 1.599e-09 Highly Informative Direct
Biological Process (BP) negative regulation of cytoskeleton organization 0 Highly Informative Direct
Biological Process (BP) regulation of protein complex disassembly 0 Highly Informative Direct
Biological Process (BP) chemotaxis 0 Highly Informative Direct
Biological Process (BP) positive regulation of neurogenesis 1.412e-13 Highly Informative Direct
Biological Process (BP) positive regulation of growth 1.979e-13 Highly Informative Direct
Biological Process (BP) actin filament organization 2.929e-13 Highly Informative Direct
Biological Process (BP) muscle organ development 3.263e-12 Highly Informative Direct
Biological Process (BP) maintenance of location 5.166e-12 Highly Informative Direct
Biological Process (BP) regulation of microtubule polymerization or depolymerization 7.344e-12 Highly Informative Direct
Biological Process (BP) cell junction organization 3.849e-11 Highly Informative Direct
Biological Process (BP) cell division 1.166e-09 Highly Informative Direct
Biological Process (BP) cellular component disassembly 8.027e-08 Highly Informative Direct
Biological Process (BP) female gamete generation 1.189e-07 Highly Informative Direct
Biological Process (BP) wound healing 1.332e-07 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 2.427e-07 Highly Informative Direct
Biological Process (BP) post-embryonic organ development 8.968e-06 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 2.093e-05 Highly Informative Direct
Biological Process (BP) locomotory behavior 5.796e-05 Highly Informative Direct
Biological Process (BP) positive regulation of GTPase activity 6.815e-05 Highly Informative Direct
Biological Process (BP) sensory perception 0.0001352 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 0.000222 Highly Informative Direct
Biological Process (BP) regulation of myeloid cell differentiation 0.0003753 Highly Informative Direct
Biological Process (BP) regulation of Rho protein signal transduction 0.0004003 Highly Informative Direct
Biological Process (BP) leukocyte migration 0.0004166 Highly Informative Direct
Biological Process (BP) nucleus organization 0.0005086 Highly Informative Direct
Biological Process (BP) renal system development 1 Highly Informative Inherited
Biological Process (BP) epithelial cell development 0.8882 Highly Informative Inherited
Biological Process (BP) regulation of cell size 0.02779 Highly Informative Inherited
Biological Process (BP) pattern specification process 1 Highly Informative Inherited
Biological Process (BP) spindle organization 0.3585 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.006375 Highly Informative Inherited
Biological Process (BP) regulation of endocytosis 1 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.001571 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.02019 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0.3352 Highly Informative Inherited
Biological Process (BP) regulation of nucleocytoplasmic transport 0.285 Highly Informative Inherited
Biological Process (BP) regulation of intracellular protein transport 0.006958 Highly Informative Inherited
Biological Process (BP) regulation of protein localization to nucleus 0.02886 Highly Informative Inherited
Biological Process (BP) regulation of protein catabolic process 0.2628 Highly Informative Inherited
Biological Process (BP) regulation of multicellular organism growth 0.00115 Highly Informative Inherited
Biological Process (BP) branching morphogenesis of an epithelial tube 0.007847 Highly Informative Inherited
Biological Process (BP) respiratory system development 0.003067 Highly Informative Inherited
Biological Process (BP) regulation of Ras GTPase activity 0.009821 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane transport 0.04992 Highly Informative Inherited
Biological Process (BP) regulation of protein complex assembly 0.2735 Highly Informative Inherited
Biological Process (BP) cell adhesion 0.01974 Highly Informative Inherited
Biological Process (BP) cell fate commitment 0.3241 Highly Informative Inherited
Biological Process (BP) cell projection assembly 0.05813 Highly Informative Inherited
Biological Process (BP) regulation of transporter activity 0.01347 Highly Informative Inherited
Biological Process (BP) positive regulation of transcription, DNA-dependent 1 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.6404 Highly Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.003396 Highly Informative Inherited
Biological Process (BP) actomyosin structure organization 1 Highly Informative Inherited
Biological Process (BP) neuron projection development 0.02415 Highly Informative Inherited
Biological Process (BP) cell part morphogenesis 0.1254 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.005126 Highly Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 0.06847 Highly Informative Inherited
Biological Process (BP) protein localization to nucleus 0.7406 Highly Informative Inherited
Biological Process (BP) nuclear import 0.1514 Highly Informative Inherited
Biological Process (BP) protein import 0.3627 Highly Informative Inherited
Biological Process (BP) protein targeting to nucleus 0.7064 Highly Informative Inherited
Biological Process (BP) protein phosphorylation 0.9884 Highly Informative Inherited
Biological Process (BP) establishment of protein localization to organelle 0.7813 Highly Informative Inherited
Biological Process (BP) regulation of blood pressure 0.01506 Highly Informative Inherited
Biological Process (BP) heart morphogenesis 0.325 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 1 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) anion binding 5.938e-05 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 6.776e-05 Moderately Informative Direct
Molecular Function (MF) oxidoreductase activity 0.8082 Moderately Informative Inherited
Molecular Function (MF) structural molecule activity 0.006795 Moderately Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0 Informative Direct
Molecular Function (MF) cofactor binding 0.004382 Informative Inherited
Molecular Function (MF) nucleotide binding 0.2252 Informative Inherited
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) GTPase regulator activity 0.3722 Informative Inherited
Molecular Function (MF) enzyme binding 0.01613 Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 0.08669 Informative Inherited
Molecular Function (MF) sulfur compound binding 0.03024 Informative Inherited
Molecular Function (MF) Ras GTPase binding 0 Highly Informative Direct
Molecular Function (MF) monooxygenase activity 1.161e-10 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 9.447e-08 Highly Informative Direct
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0.0001205 Highly Informative Direct
Molecular Function (MF) heparin binding 0.0003982 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0.4588 Highly Informative Inherited
Molecular Function (MF) small GTPase regulator activity 0.734 Highly Informative Inherited
Molecular Function (MF) kinase binding 0.1217 Highly Informative Inherited
Molecular Function (MF) tubulin binding 0.2526 Highly Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 9.108e-10 Least Informative Direct
Cellular Component (CC) protein complex 8.086e-06 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) membrane 0.006607 Least Informative Inherited
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0.9111 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 0.03489 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 0.02916 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 1 Moderately Informative Inherited
Cellular Component (CC) extracellular region part 0.4095 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 0.01816 Moderately Informative Inherited
Cellular Component (CC) contractile fiber part 0 Informative Direct
Cellular Component (CC) cell cortex 0 Informative Direct
Cellular Component (CC) nuclear envelope 0 Informative Direct
Cellular Component (CC) actin cytoskeleton 0 Informative Direct
Cellular Component (CC) cell leading edge 0 Informative Direct
Cellular Component (CC) cell junction 0 Informative Direct
Cellular Component (CC) endosome 0.7498 Informative Inherited
Cellular Component (CC) neuron projection 0.1917 Informative Inherited
Cellular Component (CC) integral to membrane 1 Informative Inherited
Cellular Component (CC) intrinsic to plasma membrane 1 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) extracellular matrix 0.06403 Informative Inherited
Cellular Component (CC) cortical cytoskeleton 2.721e-09 Highly Informative Direct
Cellular Component (CC) growth cone 0 Highly Informative Direct
Cellular Component (CC) adherens junction 0 Highly Informative Direct
Cellular Component (CC) nuclear membrane 1.589e-15 Highly Informative Direct
Cellular Component (CC) spindle 1.846e-11 Highly Informative Direct
Cellular Component (CC) apical plasma membrane 1.348e-06 Highly Informative Direct
Cellular Component (CC) cell division site part 2.292e-05 Highly Informative Direct
Cellular Component (CC) endosomal part 0.3829 Highly Informative Inherited
Cellular Component (CC) cell body 0.3205 Highly Informative Inherited
Cellular Component (CC) basolateral plasma membrane 0.08664 Highly Informative Inherited
Cellular Component (CC) receptor complex 0.3095 Highly Informative Inherited
Cellular Component (CC) integral to plasma membrane 0.7197 Highly Informative Inherited
Cellular Component (CC) intermediate filament cytoskeleton 0.2197 Highly Informative Inherited
Cellular Component (CC) organelle outer membrane 0.00294 Highly Informative Inherited
Cellular Component (CC) proteinaceous extracellular matrix 0.004586 Highly Informative Inherited

Document: GO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.2591Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle physiology0.269Moderately InformativeInherited
Phenotypic Abnormality (PA)Proximal muscle weakness7.795e-05InformativeDirect
Phenotypic Abnormality (PA)Abnormality of circulating enzyme level0.0002844InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.09113Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.7508Least InformativeInherited
Mammalian Phenotype (MP)muscle phenotype0.0006042Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal metabolism0.05005Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.2181Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal systemic arterial blood pressure0.1044InformativeInherited
Mammalian Phenotype (MP)abnormal exercise endurance4.22e-05Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.001041Least InformativeInherited
Worm Phenotype (WP)locomotion variant0.0003113Moderately InformativeDirect
Worm Phenotype (WP)early embryonic lethal0.005971Moderately InformativeInherited
Worm Phenotype (WP)organ system development variant0.006891Moderately InformativeInherited
Worm Phenotype (WP)brood size variant9.212e-07InformativeDirect
Worm Phenotype (WP)body wall muscle morphology variant1.303e-06InformativeDirect
Worm Phenotype (WP)exploded through vulva0.0002208InformativeDirect
Worm Phenotype (WP)cell division variant0.1266InformativeInherited
Worm Phenotype (WP)body wall muscle myosin organization defective3.592e-05Highly InformativeDirect
Worm Phenotype (WP)cleavage furrow defective early emb4.908e-05Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)cell0.1312Least InformativeInherited
Fly Anatomy (FA)adult0.1406Least InformativeInherited
Fly Anatomy (FA)organ system0.3767Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)adult segment0.07047Moderately InformativeInherited
Fly Anatomy (FA)adult thorax0.3926Moderately InformativeInherited
Fly Anatomy (FA)thoracic segment0.9229Moderately InformativeInherited
Fly Anatomy (FA)syncytium0.00876InformativeInherited
Fly Anatomy (FA)muscle system0.009009InformativeInherited
Fly Anatomy (FA)muscle cell0.01784InformativeInherited

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)portion of tissue0.2378Least InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.0001405Moderately InformativeDirect
Xenopus ANatomical entity (XAN)skeletal system0.0008294InformativeDirect
Xenopus ANatomical entity (XAN)bone tissue0.0001534Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCell cycle0Moderately InformativeDirect
Biological processMitosis0InformativeDirect
Biological processAngiogenesis5.722e-09InformativeDirect
Biological processCell adhesion2.624e-07InformativeDirect
Biological processWnt signaling pathway6.339e-07InformativeDirect
Biological processEndocytosis2.194e-05InformativeDirect
Biological processExocytosis8.649e-08Highly InformativeDirect
Biological processCilium biogenesis/degradation1.766e-07Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentNucleus1.92e-06Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentEndosome7.575e-05Moderately InformativeDirect
Cellular componentMicrotubule0InformativeDirect
Cellular componentSynapse1InformativeInherited
Cellular componentPostsynaptic cell membrane1.721e-06Highly InformativeDirect
Coding sequence diversityAlternative splicing0.0003726Least InformativeDirect
DomainRepeat0Least InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
DomainSH3 domain3.027e-15InformativeDirect
DomainSH2 domain1.582e-08InformativeDirect
DomainLeucine-rich repeat0.0002789InformativeDirect
DomainLIM domain0Highly InformativeDirect
Molecular functionZinc6.086e-07Least InformativeDirect
Molecular functionMetal-binding0.0006987Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionFlavoprotein3.302e-05Moderately InformativeDirect
Molecular functionActin-binding0InformativeDirect
Molecular functionCalmodulin-binding0InformativeDirect
Molecular functionFAD1.671e-07InformativeDirect
Post-translational modificationOxidoreductase1Moderately InformativeInherited
Post-translational modificationGuanine-nucleotide releasing factor0InformativeDirect
Post-translational modificationActin capping0Highly InformativeDirect
Post-translational modificationMuscle protein6.613e-12Highly InformativeDirect
Post-translational modificationMonooxygenase7.208e-12Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationAcetylation6.87e-08Least InformativeDirect

Document: KW annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 17 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Calponin-homology domain, CH-domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 17 hidden Markov models representing the Calponin-homology domain, CH-domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]