SUPERFAMILY 1.75 HMM library and genome assignments server


Calponin-homology domain, CH-domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   CH domain-like [ 47575] (3)
Superfamily:   Calponin-homology domain, CH-domain [ 47576]
Families:   Calponin-homology domain, CH-domain [ 47577] (9)


Superfamily statistics
Genomes (500) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 12,471 13,257 21
Proteins 12,220 13,060 21


Functional annotation
General category General
Detailed category General

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)localization0.032310Least InformativeInherited
Biological Process (BP)multicellular organismal process0.014990Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.013040Least InformativeInherited
Biological Process (BP)developmental process0.014970Least InformativeInherited
Biological Process (BP)single-organism cellular process0.0070450Least InformativeInherited
Biological Process (BP)macromolecule localization0.013132.657e-06Moderately InformativeInherited
Biological Process (BP)cell differentiation0.012180.1162Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.072170.2219Moderately InformativeInherited
Biological Process (BP)nervous system development0.13880.5118Moderately InformativeInherited
Biological Process (BP)system process0.072421Moderately InformativeInherited
Biological Process (BP)muscle system process0.00068070.0004452InformativeDirect
Biological Process (BP)generation of neurons0.0066420.0001052InformativeInherited
Biological Process (BP)cell projection organization0.011390InformativeInherited
Biological Process (BP)cellular component morphogenesis0.041350.001766InformativeInherited
Biological Process (BP)establishment or maintenance of cell polarity0.00028872.823e-09Highly InformativeDirect
Biological Process (BP)axon development9.774e-050.7241Highly InformativeInherited
Biological Process (BP)cell morphogenesis involved in neuron differentiation0.00010610.2141Highly InformativeInherited
Biological Process (BP)cell projection morphogenesis0.0003380.8138Highly InformativeInherited
Molecular Function (MF)binding2.221e-060Least InformativeDirect
Molecular Function (MF)cytoskeletal protein binding6.847e-160InformativeDirect
Molecular Function (MF)tubulin binding0.8540.1829Highly InformativeInherited
Cellular Component (CC)intracellular non-membrane-bounded organelle3.586e-070Least InformativeDirect
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.14094.054e-10Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)cytoskeleton0.00017920Moderately InformativeDirect
Cellular Component (CC)cell projection0.00055180Moderately InformativeDirect
Cellular Component (CC)endomembrane system0.055040.02436Moderately InformativeInherited
Cellular Component (CC)organelle envelope0.15380.04699Moderately InformativeInherited
Cellular Component (CC)nuclear part0.53971Moderately InformativeInherited
Cellular Component (CC)contractile fiber part3.53e-090InformativeDirect
Cellular Component (CC)cell cortex2.914e-070InformativeDirect
Cellular Component (CC)nuclear envelope0.00017323.128e-15InformativeDirect
Cellular Component (CC)cell-substrate junction1.932e-065.562e-08Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.05649 Least Informative Inherited
Biological Process (BP) response to stimulus 0.005144 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular localization 0 Moderately Informative Direct
Biological Process (BP) organelle organization 0 Moderately Informative Direct
Biological Process (BP) macromolecule localization 2.657e-06 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 0.0007031 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 7.432e-09 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 5.735e-05 Moderately Informative Direct
Biological Process (BP) reproduction 0.0004764 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.2585 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.421 Moderately Informative Inherited
Biological Process (BP) tissue development 0.03541 Moderately Informative Inherited
Biological Process (BP) immune system process 0.1213 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.1719 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.8471 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.2219 Moderately Informative Inherited
Biological Process (BP) homeostatic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.001582 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.1374 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.679 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.5093 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.1397 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.1162 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.5118 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.6957 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.02268 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.003556 Moderately Informative Inherited
Biological Process (BP) muscle system process 0.0004452 Informative Direct
Biological Process (BP) cellular component movement 0 Informative Direct
Biological Process (BP) generation of neurons 0.0001052 Informative Direct
Biological Process (BP) cellular membrane organization 9.528e-08 Informative Direct
Biological Process (BP) cell projection organization 0 Informative Direct
Biological Process (BP) cytoskeleton organization 0 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0 Informative Direct
Biological Process (BP) microtubule-based process 0 Informative Direct
Biological Process (BP) actin filament-based process 0 Informative Direct
Biological Process (BP) regulation of organelle organization 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) muscle structure development 1.871e-12 Informative Direct
Biological Process (BP) regulation of anatomical structure size 6.442e-12 Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 2.457e-11 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 2.409e-10 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 1.882e-09 Informative Direct
Biological Process (BP) regulation of growth 2.543e-08 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 2.986e-07 Informative Direct
Biological Process (BP) vesicle-mediated transport 9.489e-07 Informative Direct
Biological Process (BP) biological adhesion 8.392e-06 Informative Direct
Biological Process (BP) response to wounding 5.955e-05 Informative Direct
Biological Process (BP) localization of cell 0.00013 Informative Direct
Biological Process (BP) cell cycle process 0.0001973 Informative Direct
Biological Process (BP) regulation of nervous system development 0.0009704 Informative Direct
Biological Process (BP) cellular response to endogenous stimulus 0.1933 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.6988 Informative Inherited
Biological Process (BP) protein localization to organelle 0.1777 Informative Inherited
Biological Process (BP) epithelium development 0.859 Informative Inherited
Biological Process (BP) cardiovascular system development 1 Informative Inherited
Biological Process (BP) regulation of system process 0.6287 Informative Inherited
Biological Process (BP) organ morphogenesis 0.5297 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.001582 Informative Inherited
Biological Process (BP) organelle localization 0.06332 Informative Inherited
Biological Process (BP) organelle assembly 0.5932 Informative Inherited
Biological Process (BP) protein complex assembly 1 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 0.5474 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.04309 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.01246 Informative Inherited
Biological Process (BP) regulation of cell development 0.008382 Informative Inherited
Biological Process (BP) negative regulation of transport 0.06279 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.1909 Informative Inherited
Biological Process (BP) positive regulation of transport 0.9398 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.002781 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.927 Informative Inherited
Biological Process (BP) sensory organ development 0.2793 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.2605 Informative Inherited
Biological Process (BP) regulation of establishment of protein localization 0.6042 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.3453 Informative Inherited
Biological Process (BP) leukocyte activation 0.03036 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.1951 Informative Inherited
Biological Process (BP) tube development 0.1515 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.01351 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.283 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.003102 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) reproductive system development 1 Informative Inherited
Biological Process (BP) response to nutrient levels 0.00874 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.09916 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.718 Informative Inherited
Biological Process (BP) central nervous system development 0.01614 Informative Inherited
Biological Process (BP) muscle tissue development 0.7589 Informative Inherited
Biological Process (BP) positive regulation of gene expression 1 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 1 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 1 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 1 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.01255 Informative Inherited
Biological Process (BP) single-organism behavior 0.169 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.001766 Informative Inherited
Biological Process (BP) sexual reproduction 0.08768 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.6398 Informative Inherited
Biological Process (BP) single organism reproductive process 0.7272 Informative Inherited
Biological Process (BP) protein transport 0.006549 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.9086 Informative Inherited
Biological Process (BP) phosphorylation 1 Informative Inherited
Biological Process (BP) regulation of ion transport 0.1472 Informative Inherited
Biological Process (BP) blood circulation 0.001614 Informative Inherited
Biological Process (BP) embryonic organ development 1 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.5549 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.5262 Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 2.823e-09 Highly Informative Direct
Biological Process (BP) negative regulation of protein complex disassembly 0 Highly Informative Direct
Biological Process (BP) negative regulation of cytoskeleton organization 0 Highly Informative Direct
Biological Process (BP) chemotaxis 0 Highly Informative Direct
Biological Process (BP) regulation of protein depolymerization 0 Highly Informative Direct
Biological Process (BP) positive regulation of growth 1.18e-13 Highly Informative Direct
Biological Process (BP) positive regulation of neurogenesis 1.414e-13 Highly Informative Direct
Biological Process (BP) muscle organ development 1.496e-12 Highly Informative Direct
Biological Process (BP) regulation of microtubule polymerization or depolymerization 3.211e-12 Highly Informative Direct
Biological Process (BP) actin filament organization 3.246e-12 Highly Informative Direct
Biological Process (BP) maintenance of location 7.362e-12 Highly Informative Direct
Biological Process (BP) cell junction organization 6.266e-11 Highly Informative Direct
Biological Process (BP) cell division 1.781e-09 Highly Informative Direct
Biological Process (BP) female gamete generation 8.915e-08 Highly Informative Direct
Biological Process (BP) cellular component disassembly 9.576e-08 Highly Informative Direct
Biological Process (BP) wound healing 1.109e-07 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 2.881e-07 Highly Informative Direct
Biological Process (BP) post-embryonic organ development 1.229e-05 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 3.046e-05 Highly Informative Direct
Biological Process (BP) locomotory behavior 4.83e-05 Highly Informative Direct
Biological Process (BP) sensory perception 0.000147 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 0.0002527 Highly Informative Direct
Biological Process (BP) regulation of myeloid cell differentiation 0.0004001 Highly Informative Direct
Biological Process (BP) leukocyte migration 0.0004009 Highly Informative Direct
Biological Process (BP) nucleus organization 0.0005707 Highly Informative Direct
Biological Process (BP) renal system development 1 Highly Informative Inherited
Biological Process (BP) epithelial cell development 0.91 Highly Informative Inherited
Biological Process (BP) regulation of cell size 0.01078 Highly Informative Inherited
Biological Process (BP) pattern specification process 1 Highly Informative Inherited
Biological Process (BP) spindle organization 0.3888 Highly Informative Inherited
Biological Process (BP) regulation of protein stability 0.1612 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.007965 Highly Informative Inherited
Biological Process (BP) regulation of endocytosis 1 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.001981 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.02026 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0.3376 Highly Informative Inherited
Biological Process (BP) developmental maturation 1 Highly Informative Inherited
Biological Process (BP) regulation of nucleocytoplasmic transport 0.3031 Highly Informative Inherited
Biological Process (BP) regulation of intracellular protein transport 0.007366 Highly Informative Inherited
Biological Process (BP) regulation of protein localization to nucleus 0.0326 Highly Informative Inherited
Biological Process (BP) regulation of protein catabolic process 0.2591 Highly Informative Inherited
Biological Process (BP) regulation of multicellular organism growth 0.001262 Highly Informative Inherited
Biological Process (BP) branching morphogenesis of an epithelial tube 0.008395 Highly Informative Inherited
Biological Process (BP) respiratory system development 0.003968 Highly Informative Inherited
Biological Process (BP) regulation of Rho GTPase activity 0.001387 Highly Informative Inherited
Biological Process (BP) positive regulation of Ras GTPase activity 0.1704 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane transport 0.05164 Highly Informative Inherited
Biological Process (BP) regulation of protein complex assembly 0.4156 Highly Informative Inherited
Biological Process (BP) cell adhesion 0.02358 Highly Informative Inherited
Biological Process (BP) cell fate commitment 0.3885 Highly Informative Inherited
Biological Process (BP) cell projection assembly 0.05693 Highly Informative Inherited
Biological Process (BP) regulation of transporter activity 0.01427 Highly Informative Inherited
Biological Process (BP) positive regulation of transcription, DNA-dependent 1 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.6462 Highly Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.002898 Highly Informative Inherited
Biological Process (BP) actomyosin structure organization 1 Highly Informative Inherited
Biological Process (BP) microtubule-based movement 1 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in neuron differentiation 0.2141 Highly Informative Inherited
Biological Process (BP) cell projection morphogenesis 0.8138 Highly Informative Inherited
Biological Process (BP) axon development 0.7241 Highly Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 0.1006 Highly Informative Inherited
Biological Process (BP) protein localization to nucleus 0.7266 Highly Informative Inherited
Biological Process (BP) nuclear import 0.1677 Highly Informative Inherited
Biological Process (BP) protein import 0.3901 Highly Informative Inherited
Biological Process (BP) protein targeting to nucleus 0.7029 Highly Informative Inherited
Biological Process (BP) protein phosphorylation 0.9867 Highly Informative Inherited
Biological Process (BP) establishment of protein localization to organelle 0.7959 Highly Informative Inherited
Biological Process (BP) regulation of blood pressure 0.01537 Highly Informative Inherited
Biological Process (BP) heart morphogenesis 0.3271 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 1 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) anion binding 3.764e-05 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 6.562e-05 Moderately Informative Direct
Molecular Function (MF) oxidoreductase activity 0.7663 Moderately Informative Inherited
Molecular Function (MF) structural molecule activity 0.007119 Moderately Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0 Informative Direct
Molecular Function (MF) cofactor binding 0.003213 Informative Inherited
Molecular Function (MF) nucleotide binding 0.2323 Informative Inherited
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) GTPase regulator activity 0.3831 Informative Inherited
Molecular Function (MF) enzyme binding 0.02236 Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 0.09193 Informative Inherited
Molecular Function (MF) sulfur compound binding 0.03039 Informative Inherited
Molecular Function (MF) actin binding 0 Highly Informative Direct
Molecular Function (MF) Ras GTPase binding 0 Highly Informative Direct
Molecular Function (MF) monooxygenase activity 6.216e-11 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 6.421e-08 Highly Informative Direct
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0.0001293 Highly Informative Direct
Molecular Function (MF) heparin binding 0.0004523 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0.4778 Highly Informative Inherited
Molecular Function (MF) small GTPase regulator activity 0.7077 Highly Informative Inherited
Molecular Function (MF) kinase binding 0.1045 Highly Informative Inherited
Molecular Function (MF) tubulin binding 0.1829 Highly Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 4.054e-10 Least Informative Direct
Cellular Component (CC) protein complex 7.5e-06 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) membrane 0.002786 Least Informative Inherited
Cellular Component (CC) cytoskeleton 0 Moderately Informative Direct
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0.9087 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 0.02436 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 0.04699 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 1 Moderately Informative Inherited
Cellular Component (CC) extracellular region part 0.3557 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 0.01022 Moderately Informative Inherited
Cellular Component (CC) contractile fiber part 0 Informative Direct
Cellular Component (CC) cell cortex 0 Informative Direct
Cellular Component (CC) nuclear envelope 3.128e-15 Informative Direct
Cellular Component (CC) actin cytoskeleton 0 Informative Direct
Cellular Component (CC) cell leading edge 0 Informative Direct
Cellular Component (CC) endosome 0.7335 Informative Inherited
Cellular Component (CC) neuron projection 0.7604 Informative Inherited
Cellular Component (CC) cell-cell junction 1 Informative Inherited
Cellular Component (CC) integral to membrane 1 Informative Inherited
Cellular Component (CC) intrinsic to plasma membrane 1 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) extracellular matrix 0.05685 Informative Inherited
Cellular Component (CC) cell-substrate junction 5.562e-08 Highly Informative Direct
Cellular Component (CC) cortical cytoskeleton 8.975e-10 Highly Informative Direct
Cellular Component (CC) adherens junction 0 Highly Informative Direct
Cellular Component (CC) nuclear membrane 1.61e-15 Highly Informative Direct
Cellular Component (CC) spindle 8.178e-12 Highly Informative Direct
Cellular Component (CC) growth cone 1.332e-07 Highly Informative Direct
Cellular Component (CC) apical plasma membrane 1.082e-06 Highly Informative Direct
Cellular Component (CC) cell division site part 1.905e-05 Highly Informative Direct
Cellular Component (CC) endosomal part 0.3847 Highly Informative Inherited
Cellular Component (CC) cell body 0.2964 Highly Informative Inherited
Cellular Component (CC) basolateral plasma membrane 0.06904 Highly Informative Inherited
Cellular Component (CC) receptor complex 0.3142 Highly Informative Inherited
Cellular Component (CC) integral to plasma membrane 0.7179 Highly Informative Inherited
Cellular Component (CC) intermediate filament cytoskeleton 0.05968 Highly Informative Inherited
Cellular Component (CC) organelle outer membrane 0.002712 Highly Informative Inherited
Cellular Component (CC) proteinaceous extracellular matrix 0.004101 Highly Informative Inherited

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.7043Least InformativeInherited
Disease Ontology (DO)neuropathy0.02686InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.2627Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle physiology0.2741Moderately InformativeInherited
Phenotypic Abnormality (PA)Proximal muscle weakness7.469e-05InformativeDirect
Phenotypic Abnormality (PA)Abnormality of circulating enzyme level0.0002977InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.1229Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.8753Least InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.09261Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.2516Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal systemic arterial blood pressure0.07989InformativeInherited
Mammalian Phenotype (MP)abnormal exercise endurance0.0002891Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.001041Least InformativeInherited
Worm Phenotype (WP)locomotion variant0.0003113Moderately InformativeDirect
Worm Phenotype (WP)early embryonic lethal0.005971Moderately InformativeInherited
Worm Phenotype (WP)organ system development variant0.006891Moderately InformativeInherited
Worm Phenotype (WP)brood size variant9.212e-07InformativeDirect
Worm Phenotype (WP)body wall muscle morphology variant1.303e-06InformativeDirect
Worm Phenotype (WP)exploded through vulva0.0002208InformativeDirect
Worm Phenotype (WP)cell division variant0.1266InformativeInherited
Worm Phenotype (WP)body wall muscle myosin organization defective3.592e-05Highly InformativeDirect
Worm Phenotype (WP)cleavage furrow defective early emb4.908e-05Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)cell0.1364Least InformativeInherited
Fly Anatomy (FA)organ system0.3826Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)adult segment0.06985Moderately InformativeInherited
Fly Anatomy (FA)adult thorax0.3916Moderately InformativeInherited
Fly Anatomy (FA)thoracic segment0.9283Moderately InformativeInherited
Fly Anatomy (FA)syncytium0.007959InformativeInherited
Fly Anatomy (FA)muscle system0.008371InformativeInherited
Fly Anatomy (FA)muscle cell0.0162InformativeInherited

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)portion of tissue0.2348Least InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.0001383Moderately InformativeDirect
Xenopus ANatomical entity (XAN)skeletal system0.0008158InformativeDirect
Xenopus ANatomical entity (XAN)bone tissue0.0001534Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCell cycle0Moderately InformativeDirect
Biological processMitosis0InformativeDirect
Biological processAngiogenesis5.77e-09InformativeDirect
Biological processCell adhesion2.607e-07InformativeDirect
Biological processWnt signaling pathway6.384e-07InformativeDirect
Biological processEndocytosis2.113e-05InformativeDirect
Biological processExocytosis8.703e-08Highly InformativeDirect
Biological processCilium biogenesis/degradation1.629e-07Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentNucleus1.846e-06Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentEndosome7.17e-05Moderately InformativeDirect
Cellular componentMicrotubule0InformativeDirect
Cellular componentSynapse1InformativeInherited
Cellular componentPostsynaptic cell membrane1.727e-06Highly InformativeDirect
Coding sequence diversityAlternative splicing0.0004542Least InformativeDirect
DomainRepeat0Least InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
DomainSH3 domain3.337e-15InformativeDirect
DomainSH2 domain1.612e-08InformativeDirect
DomainLeucine-rich repeat0.0002833InformativeDirect
DomainLIM domain0Highly InformativeDirect
Molecular functionZinc5.171e-07Least InformativeDirect
Molecular functionMetal-binding0.0004954Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionFlavoprotein3.353e-05Moderately InformativeDirect
Molecular functionActin-binding0InformativeDirect
Molecular functionCalmodulin-binding0InformativeDirect
Molecular functionFAD1.669e-07InformativeDirect
Post-translational modificationOxidoreductase1Moderately InformativeInherited
Post-translational modificationGuanine-nucleotide releasing factor0InformativeDirect
Post-translational modificationActin capping0Highly InformativeDirect
Post-translational modificationMuscle protein6.672e-12Highly InformativeDirect
Post-translational modificationMonooxygenase6.992e-12Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationAcetylation6.821e-08Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 17 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Calponin-homology domain, CH-domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 17 hidden Markov models representing the Calponin-homology domain, CH-domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]