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Calponin-homology domain, CH-domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   CH domain-like [ 47575] (3)
Superfamily:   Calponin-homology domain, CH-domain [ 47576]
Families:   Calponin-homology domain, CH-domain [ 47577] (9)


Superfamily statistics
Genomes (500) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 12,471 13,257 21
Proteins 12,220 13,060 21


Functional annotation
General category General
Detailed category General

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)localization0.11750Least InformativeInherited
Biological Process (BP)single-organism cellular process0.018330Least InformativeInherited
Biological Process (BP)multicellular organismal process0.058420Least InformativeInherited
Biological Process (BP)macromolecule localization0.0012280.000001092Moderately InformativeInherited
Biological Process (BP)system process0.021581Moderately InformativeInherited
Biological Process (BP)muscle system process0.00068020.0004827InformativeDirect
Biological Process (BP)establishment or maintenance of cell polarity0.00015130.000000001542Highly InformativeDirect
Molecular Function (MF)binding0.0000080450Least InformativeDirect
Molecular Function (MF)cytoskeletal protein binding0.000000000000089250InformativeDirect
Cellular Component (CC)intracellular non-membrane-bounded organelle0.00000310Least InformativeDirect
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.080720.000000001715Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)cell projection0.00036030Moderately InformativeDirect
Cellular Component (CC)cytoskeleton0.00071240Moderately InformativeDirect
Cellular Component (CC)endomembrane system0.04360.02746Moderately InformativeInherited
Cellular Component (CC)organelle envelope0.15420.04537Moderately InformativeInherited
Cellular Component (CC)nuclear part0.53711Moderately InformativeInherited
Cellular Component (CC)contractile fiber part0.000000003520InformativeDirect
Cellular Component (CC)cell cortex0.00000017210InformativeDirect
Cellular Component (CC)nuclear envelope0.00012380.000000000000003092InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.05998 Least Informative Inherited
Biological Process (BP) response to stimulus 0.00505 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) macromolecule localization 0.000001092 Moderately Informative Direct
Biological Process (BP) cellular localization 0 Moderately Informative Direct
Biological Process (BP) organelle organization 0 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 0.000000000001112 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0.00000001255 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.00001481 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0.00007903 Moderately Informative Direct
Biological Process (BP) reproduction 0.0004114 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.2362 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.4301 Moderately Informative Inherited
Biological Process (BP) tissue development 0.02515 Moderately Informative Inherited
Biological Process (BP) immune system process 0.1152 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.1483 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.002138 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.7958 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.2383 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.002134 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.1118 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.714 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.5173 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.1478 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.1261 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.561 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.7032 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.02787 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.9608 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.002372 Moderately Informative Inherited
Biological Process (BP) muscle system process 0.0004827 Informative Direct
Biological Process (BP) cellular membrane organization 0.00000007657 Informative Direct
Biological Process (BP) cellular component movement 0 Informative Direct
Biological Process (BP) cytoskeleton organization 0 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0 Informative Direct
Biological Process (BP) microtubule-based process 0 Informative Direct
Biological Process (BP) actin filament-based process 0 Informative Direct
Biological Process (BP) regulation of organelle organization 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) cell projection organization 0 Informative Direct
Biological Process (BP) muscle structure development 0.000000000001043 Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 0.00000000005353 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.0000000002934 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0.000000003514 Informative Direct
Biological Process (BP) regulation of growth 0.00000001819 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.0000002246 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0.0000005062 Informative Direct
Biological Process (BP) biological adhesion 0.000007795 Informative Direct
Biological Process (BP) response to wounding 0.00007092 Informative Direct
Biological Process (BP) localization of cell 0.00008418 Informative Direct
Biological Process (BP) generation of neurons 0.0001351 Informative Direct
Biological Process (BP) cell cycle process 0.0001438 Informative Direct
Biological Process (BP) regulation of nervous system development 0.0009161 Informative Direct
Biological Process (BP) cellular response to endogenous stimulus 0.2156 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.715 Informative Inherited
Biological Process (BP) protein localization to organelle 0.1714 Informative Inherited
Biological Process (BP) epithelium development 0.8592 Informative Inherited
Biological Process (BP) cardiovascular system development 1 Informative Inherited
Biological Process (BP) regulation of system process 0.647 Informative Inherited
Biological Process (BP) organ morphogenesis 0.4738 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.00143 Informative Inherited
Biological Process (BP) organelle localization 0.04402 Informative Inherited
Biological Process (BP) organelle assembly 0.5631 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.0359 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.01108 Informative Inherited
Biological Process (BP) regulation of cell development 0.008108 Informative Inherited
Biological Process (BP) negative regulation of transport 0.06518 Informative Inherited
Biological Process (BP) regulation of vesicle-mediated transport 0.5493 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.1967 Informative Inherited
Biological Process (BP) positive regulation of transport 0.9349 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.002891 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.9186 Informative Inherited
Biological Process (BP) sensory organ development 0.2448 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.1349 Informative Inherited
Biological Process (BP) regulation of establishment of protein localization 0.603 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.3509 Informative Inherited
Biological Process (BP) leukocyte activation 0.03049 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.1911 Informative Inherited
Biological Process (BP) tube development 0.1336 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.01057 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.2833 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.003543 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) reproductive system development 1 Informative Inherited
Biological Process (BP) response to nutrient levels 0.01229 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.09307 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.6901 Informative Inherited
Biological Process (BP) central nervous system development 0.01337 Informative Inherited
Biological Process (BP) muscle tissue development 0.7587 Informative Inherited
Biological Process (BP) positive regulation of gene expression 1 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 1 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 1 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 1 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.01022 Informative Inherited
Biological Process (BP) single-organism behavior 0.1753 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.003059 Informative Inherited
Biological Process (BP) sexual reproduction 0.08403 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.6392 Informative Inherited
Biological Process (BP) single organism reproductive process 0.6988 Informative Inherited
Biological Process (BP) protein transport 0.007114 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.9072 Informative Inherited
Biological Process (BP) phosphorylation 1 Informative Inherited
Biological Process (BP) regulation of ion transport 0.147 Informative Inherited
Biological Process (BP) blood circulation 0.001758 Informative Inherited
Biological Process (BP) embryonic organ development 1 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.5082 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.5188 Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 0.000000001542 Highly Informative Direct
Biological Process (BP) negative regulation of cytoskeleton organization 0 Highly Informative Direct
Biological Process (BP) regulation of protein complex disassembly 0 Highly Informative Direct
Biological Process (BP) chemotaxis 0 Highly Informative Direct
Biological Process (BP) positive regulation of neurogenesis 0.00000000000009548 Highly Informative Direct
Biological Process (BP) positive regulation of growth 0.0000000000001362 Highly Informative Direct
Biological Process (BP) actin filament organization 0.0000000000009539 Highly Informative Direct
Biological Process (BP) muscle organ development 0.000000000002628 Highly Informative Direct
Biological Process (BP) maintenance of location 0.000000000005201 Highly Informative Direct
Biological Process (BP) regulation of microtubule polymerization or depolymerization 0.000000000008337 Highly Informative Direct
Biological Process (BP) cell junction organization 0.00000000004728 Highly Informative Direct
Biological Process (BP) cell division 0.000000001241 Highly Informative Direct
Biological Process (BP) cellular component disassembly 0.00000008295 Highly Informative Direct
Biological Process (BP) female gamete generation 0.00000009364 Highly Informative Direct
Biological Process (BP) wound healing 0.0000001239 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 0.0000002694 Highly Informative Direct
Biological Process (BP) post-embryonic organ development 0.000009202 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.00002694 Highly Informative Direct
Biological Process (BP) locomotory behavior 0.0000658 Highly Informative Direct
Biological Process (BP) sensory perception 0.0001472 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 0.0002127 Highly Informative Direct
Biological Process (BP) regulation of myeloid cell differentiation 0.0003913 Highly Informative Direct
Biological Process (BP) leukocyte migration 0.0004018 Highly Informative Direct
Biological Process (BP) nucleus organization 0.0005114 Highly Informative Direct
Biological Process (BP) renal system development 1 Highly Informative Inherited
Biological Process (BP) epithelial cell development 0.882 Highly Informative Inherited
Biological Process (BP) regulation of cell size 0.009744 Highly Informative Inherited
Biological Process (BP) pattern specification process 1 Highly Informative Inherited
Biological Process (BP) spindle organization 0.3577 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.006577 Highly Informative Inherited
Biological Process (BP) regulation of endocytosis 1 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.001612 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.02017 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0.3258 Highly Informative Inherited
Biological Process (BP) developmental maturation 1 Highly Informative Inherited
Biological Process (BP) regulation of nucleocytoplasmic transport 0.2933 Highly Informative Inherited
Biological Process (BP) regulation of intracellular protein transport 0.00699 Highly Informative Inherited
Biological Process (BP) regulation of protein localization to nucleus 0.03081 Highly Informative Inherited
Biological Process (BP) regulation of protein catabolic process 0.2599 Highly Informative Inherited
Biological Process (BP) regulation of multicellular organism growth 0.001223 Highly Informative Inherited
Biological Process (BP) branching morphogenesis of an epithelial tube 0.007912 Highly Informative Inherited
Biological Process (BP) respiratory system development 0.003061 Highly Informative Inherited
Biological Process (BP) regulation of Rho GTPase activity 0.001188 Highly Informative Inherited
Biological Process (BP) positive regulation of Ras GTPase activity 0.1836 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane transport 0.0481 Highly Informative Inherited
Biological Process (BP) regulation of protein complex assembly 0.3742 Highly Informative Inherited
Biological Process (BP) cell adhesion 0.0207 Highly Informative Inherited
Biological Process (BP) cell fate commitment 0.3399 Highly Informative Inherited
Biological Process (BP) cell projection assembly 0.05311 Highly Informative Inherited
Biological Process (BP) regulation of transporter activity 0.01385 Highly Informative Inherited
Biological Process (BP) positive regulation of transcription, DNA-dependent 1 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.6402 Highly Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.00284 Highly Informative Inherited
Biological Process (BP) actomyosin structure organization 1 Highly Informative Inherited
Biological Process (BP) neuron projection development 0.02651 Highly Informative Inherited
Biological Process (BP) cell part morphogenesis 0.1263 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.005959 Highly Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 0.1031 Highly Informative Inherited
Biological Process (BP) protein localization to nucleus 0.7351 Highly Informative Inherited
Biological Process (BP) nuclear import 0.1499 Highly Informative Inherited
Biological Process (BP) protein import 0.3613 Highly Informative Inherited
Biological Process (BP) protein targeting to nucleus 0.701 Highly Informative Inherited
Biological Process (BP) protein phosphorylation 0.9868 Highly Informative Inherited
Biological Process (BP) establishment of protein localization to organelle 0.7896 Highly Informative Inherited
Biological Process (BP) regulation of blood pressure 0.01497 Highly Informative Inherited
Biological Process (BP) heart morphogenesis 0.3268 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 1 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) anion binding 0.00005176 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 0.00006426 Moderately Informative Direct
Molecular Function (MF) oxidoreductase activity 0.8004 Moderately Informative Inherited
Molecular Function (MF) structural molecule activity 0.006776 Moderately Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0 Informative Direct
Molecular Function (MF) cofactor binding 0.004148 Informative Inherited
Molecular Function (MF) nucleotide binding 0.2268 Informative Inherited
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) GTPase regulator activity 0.379 Informative Inherited
Molecular Function (MF) enzyme binding 0.02266 Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 0.08643 Informative Inherited
Molecular Function (MF) sulfur compound binding 0.02967 Informative Inherited
Molecular Function (MF) Ras GTPase binding 0 Highly Informative Direct
Molecular Function (MF) monooxygenase activity 0.0000000001071 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 0.00000008977 Highly Informative Direct
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0.0001205 Highly Informative Direct
Molecular Function (MF) heparin binding 0.0004209 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0.4651 Highly Informative Inherited
Molecular Function (MF) small GTPase regulator activity 0.7353 Highly Informative Inherited
Molecular Function (MF) kinase binding 0.09986 Highly Informative Inherited
Molecular Function (MF) tubulin binding 0.2414 Highly Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.000000001715 Least Informative Direct
Cellular Component (CC) protein complex 0.000007309 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) membrane 0.005673 Least Informative Inherited
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0.9033 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 0.02746 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 0.04537 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 1 Moderately Informative Inherited
Cellular Component (CC) extracellular region part 0.4066 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 0.01682 Moderately Informative Inherited
Cellular Component (CC) contractile fiber part 0 Informative Direct
Cellular Component (CC) cell cortex 0 Informative Direct
Cellular Component (CC) nuclear envelope 0.000000000000003092 Informative Direct
Cellular Component (CC) actin cytoskeleton 0 Informative Direct
Cellular Component (CC) cell leading edge 0 Informative Direct
Cellular Component (CC) cell junction 0 Informative Direct
Cellular Component (CC) endosome 0.7441 Informative Inherited
Cellular Component (CC) neuron projection 0.1475 Informative Inherited
Cellular Component (CC) integral to membrane 1 Informative Inherited
Cellular Component (CC) intrinsic to plasma membrane 1 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) extracellular matrix 0.06357 Informative Inherited
Cellular Component (CC) cortical cytoskeleton 0.000000003051 Highly Informative Direct
Cellular Component (CC) growth cone 0 Highly Informative Direct
Cellular Component (CC) adherens junction 0 Highly Informative Direct
Cellular Component (CC) nuclear membrane 0.000000000000001594 Highly Informative Direct
Cellular Component (CC) spindle 0.00000000001809 Highly Informative Direct
Cellular Component (CC) apical plasma membrane 0.00000131 Highly Informative Direct
Cellular Component (CC) cell division site part 0.00002169 Highly Informative Direct
Cellular Component (CC) endosomal part 0.3844 Highly Informative Inherited
Cellular Component (CC) cell body 0.3216 Highly Informative Inherited
Cellular Component (CC) basolateral plasma membrane 0.08634 Highly Informative Inherited
Cellular Component (CC) receptor complex 0.311 Highly Informative Inherited
Cellular Component (CC) integral to plasma membrane 0.7188 Highly Informative Inherited
Cellular Component (CC) intermediate filament cytoskeleton 0.2233 Highly Informative Inherited
Cellular Component (CC) organelle outer membrane 0.00293 Highly Informative Inherited
Cellular Component (CC) proteinaceous extracellular matrix 0.004073 Highly Informative Inherited

Document: GO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.2591Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle physiology0.2714Moderately InformativeInherited
Phenotypic Abnormality (PA)Proximal muscle weakness0.00007902InformativeDirect
Phenotypic Abnormality (PA)Abnormality of circulating enzyme level0.0002876InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.1228Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.6944Least InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.09329Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.2539Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal systemic arterial blood pressure0.08142InformativeInherited
Mammalian Phenotype (MP)abnormal exercise endurance0.0002828Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.001041Least InformativeInherited
Worm Phenotype (WP)locomotion variant0.0003113Moderately InformativeDirect
Worm Phenotype (WP)early embryonic lethal0.005971Moderately InformativeInherited
Worm Phenotype (WP)organ system development variant0.006891Moderately InformativeInherited
Worm Phenotype (WP)brood size variant0.0000009212InformativeDirect
Worm Phenotype (WP)body wall muscle morphology variant0.000001303InformativeDirect
Worm Phenotype (WP)exploded through vulva0.0002208InformativeDirect
Worm Phenotype (WP)cell division variant0.1266InformativeInherited
Worm Phenotype (WP)body wall muscle myosin organization defective0.00003592Highly InformativeDirect
Worm Phenotype (WP)cleavage furrow defective early emb0.00004908Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)cell0.1316Least InformativeInherited
Fly Anatomy (FA)adult0.1402Least InformativeInherited
Fly Anatomy (FA)organ system0.3763Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)adult segment0.07026Moderately InformativeInherited
Fly Anatomy (FA)adult thorax0.3917Moderately InformativeInherited
Fly Anatomy (FA)thoracic segment0.9225Moderately InformativeInherited
Fly Anatomy (FA)syncytium0.008763InformativeInherited
Fly Anatomy (FA)muscle system0.009025InformativeInherited
Fly Anatomy (FA)muscle cell0.01785InformativeInherited

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)portion of tissue0.2356Least InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.0001384Moderately InformativeDirect
Xenopus ANatomical entity (XAN)skeletal system0.0008153InformativeDirect
Xenopus ANatomical entity (XAN)bone tissue0.0001535Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCell cycle0Moderately InformativeDirect
Biological processMitosis0InformativeDirect
Biological processAngiogenesis0.00000000577InformativeDirect
Biological processCell adhesion0.0000002607InformativeDirect
Biological processWnt signaling pathway0.0000006384InformativeDirect
Biological processEndocytosis0.00002113InformativeDirect
Biological processExocytosis0.00000008703Highly InformativeDirect
Biological processCilium biogenesis/degradation0.0000001629Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentNucleus0.000001846Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentEndosome0.0000717Moderately InformativeDirect
Cellular componentMicrotubule0InformativeDirect
Cellular componentSynapse1InformativeInherited
Cellular componentPostsynaptic cell membrane0.000001727Highly InformativeDirect
Coding sequence diversityAlternative splicing0.0004542Least InformativeDirect
DomainRepeat0Least InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
DomainSH3 domain0.000000000000003337InformativeDirect
DomainSH2 domain0.00000001612InformativeDirect
DomainLeucine-rich repeat0.0002833InformativeDirect
DomainLIM domain0Highly InformativeDirect
Molecular functionZinc0.0000005171Least InformativeDirect
Molecular functionMetal-binding0.0004954Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionFlavoprotein0.00003353Moderately InformativeDirect
Molecular functionActin-binding0InformativeDirect
Molecular functionCalmodulin-binding0InformativeDirect
Molecular functionFAD0.0000001669InformativeDirect
Post-translational modificationOxidoreductase1Moderately InformativeInherited
Post-translational modificationGuanine-nucleotide releasing factor0InformativeDirect
Post-translational modificationActin capping0Highly InformativeDirect
Post-translational modificationMuscle protein0.000000000006672Highly InformativeDirect
Post-translational modificationMonooxygenase0.000000000006992Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationAcetylation0.00000006821Least InformativeDirect

Document: KW annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 17 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Calponin-homology domain, CH-domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 17 hidden Markov models representing the Calponin-homology domain, CH-domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]