SUPERFAMILY 1.75 HMM library and genome assignments server

Calponin-homology domain, CH-domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   CH domain-like [ 47575] (3)
Superfamily:   Calponin-homology domain, CH-domain [ 47576]
Families:   Calponin-homology domain, CH-domain [ 47577] (9)


Superfamily statistics
Genomes (501) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 12,486 13,257 21
Proteins 12,235 13,060 21


Functional annotation
General category General
Detailed category General

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular component organization or biogenesis0.0083780Least InformativeInherited
Biological Process (BP)localization0.13450Least InformativeInherited
Biological Process (BP)single-organism cellular process0.23340.00000000009597Least InformativeInherited
Biological Process (BP)multicellular organismal process0.11960Least InformativeInherited
Biological Process (BP)macromolecule localization0.0012030.00001065Moderately InformativeInherited
Biological Process (BP)cellular localization0.0044940Moderately InformativeInherited
Biological Process (BP)single-organism membrane organization0.00019530.000000000000003707InformativeDirect
Biological Process (BP)muscle system process0.0015070.002106InformativeInherited
Biological Process (BP)establishment or maintenance of cell polarity0.000040310.00000000001421Highly InformativeDirect
Molecular Function (MF)binding0.0000090040Least InformativeDirect
Molecular Function (MF)cytoskeletal protein binding0.000000000000084620InformativeDirect
Molecular Function (MF)protein complex binding0.0000064020InformativeDirect
Cellular Component (CC)non-membrane-bounded organelle0.0000033210Least InformativeDirect
Cellular Component (CC)intracellular organelle part0.036050Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.91451Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)cell projection0.000009170Moderately InformativeDirect
Cellular Component (CC)cytoskeleton0.00046120Moderately InformativeDirect
Cellular Component (CC)organelle envelope0.07750.07764Moderately InformativeInherited
Cellular Component (CC)nuclear part0.57181Moderately InformativeInherited
Cellular Component (CC)contractile fiber part0.0000000057310InformativeDirect
Cellular Component (CC)cell cortex0.0000010390InformativeDirect
Cellular Component (CC)nuclear envelope0.00012480InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.00000000009597 Least Informative Direct
Biological Process (BP) response to stimulus 0.006519 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.1088 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) positive regulation of biological process 0.4827 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) macromolecule localization 0.00001065 Moderately Informative Direct
Biological Process (BP) cellular localization 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0 Moderately Informative Direct
Biological Process (BP) single-organism organelle organization 0 Moderately Informative Direct
Biological Process (BP) regulation of phosphorus metabolic process 0.0000003161 Moderately Informative Direct
Biological Process (BP) response to external stimulus 0.000001483 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.000008366 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0.0002141 Moderately Informative Direct
Biological Process (BP) reproductive process 0.000641 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.2803 Moderately Informative Inherited
Biological Process (BP) immune system process 0.1182 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.4481 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.003271 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.8151 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.1021 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.1591 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.8387 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.8479 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.5374 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.859 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.08302 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.003519 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.003434 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.1661 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.7974 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.6841 Moderately Informative Inherited
Biological Process (BP) oxidation-reduction process 0.007694 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.0917 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.9446 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.1259 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) single-organism membrane organization 0.000000000000003707 Informative Direct
Biological Process (BP) cellular component movement 0 Informative Direct
Biological Process (BP) cytoskeleton organization 0 Informative Direct
Biological Process (BP) microtubule-based process 0 Informative Direct
Biological Process (BP) actin filament-based process 0 Informative Direct
Biological Process (BP) cell projection organization 0 Informative Direct
Biological Process (BP) regulation of organelle organization 0 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) muscle structure development 0.000000000000007248 Informative Direct
Biological Process (BP) single-organism intracellular transport 0.0000000000001499 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0.000000000004442 Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 0.00000000008625 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.0000000001874 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0.000000006447 Informative Direct
Biological Process (BP) regulation of growth 0.00000001034 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.00000007413 Informative Direct
Biological Process (BP) cell division 0.00000007747 Informative Direct
Biological Process (BP) positive regulation of catabolic process 0.000001377 Informative Direct
Biological Process (BP) cell cycle process 0.000001384 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0.000001445 Informative Direct
Biological Process (BP) biological adhesion 0.0000055 Informative Direct
Biological Process (BP) localization of cell 0.00004943 Informative Direct
Biological Process (BP) tissue morphogenesis 0.00007606 Informative Direct
Biological Process (BP) generation of neurons 0.000152 Informative Direct
Biological Process (BP) single-organism cellular localization 0.0004797 Informative Direct
Biological Process (BP) regulation of nervous system development 0.0006038 Informative Direct
Biological Process (BP) regulation of ion transport 0.1568 Informative Inherited
Biological Process (BP) regulation of system process 0.3177 Informative Inherited
Biological Process (BP) cellular response to hormone stimulus 0.08804 Informative Inherited
Biological Process (BP) single organism reproductive process 0.1916 Informative Inherited
Biological Process (BP) organelle localization 0.04989 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 0.9389 Informative Inherited
Biological Process (BP) organelle assembly 0.6443 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.01007 Informative Inherited
Biological Process (BP) negative regulation of transport 0.07721 Informative Inherited
Biological Process (BP) regulation of vesicle-mediated transport 0.5851 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.005007 Informative Inherited
Biological Process (BP) positive regulation of transport 0.9672 Informative Inherited
Biological Process (BP) anatomical structure homeostasis 0.04991 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.001099 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.3269 Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.221 Informative Inherited
Biological Process (BP) negative regulation of developmental process 1 Informative Inherited
Biological Process (BP) protein localization to organelle 0.1694 Informative Inherited
Biological Process (BP) sensory organ development 0.08335 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.002782 Informative Inherited
Biological Process (BP) regulation of protein localization 0.833 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.1829 Informative Inherited
Biological Process (BP) leukocyte activation 0.02981 Informative Inherited
Biological Process (BP) tube development 0.498 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.1471 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.955 Informative Inherited
Biological Process (BP) reproductive structure development 1 Informative Inherited
Biological Process (BP) response to nutrient levels 0.02087 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.43 Informative Inherited
Biological Process (BP) central nervous system development 0.01352 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.02962 Informative Inherited
Biological Process (BP) regulation of cell development 0.01064 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.002122 Informative Inherited
Biological Process (BP) positive regulation of RNA metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 1 Informative Inherited
Biological Process (BP) positive regulation of gene expression 1 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 1 Informative Inherited
Biological Process (BP) sexual reproduction 0.1596 Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.009618 Informative Inherited
Biological Process (BP) neurological system process 0.8247 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.5896 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.9465 Informative Inherited
Biological Process (BP) phosphorylation 1 Informative Inherited
Biological Process (BP) muscle system process 0.002106 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.2387 Informative Inherited
Biological Process (BP) protein transport 0.9794 Informative Inherited
Biological Process (BP) blood circulation 0.002172 Informative Inherited
Biological Process (BP) cardiovascular system development 1 Informative Inherited
Biological Process (BP) epithelium development 0.6817 Informative Inherited
Biological Process (BP) organ morphogenesis 0.1498 Informative Inherited
Biological Process (BP) embryonic organ development 1 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.202 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.01072 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.6564 Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 0.00000000001421 Highly Informative Direct
Biological Process (BP) regulation of protein complex disassembly 0 Highly Informative Direct
Biological Process (BP) negative regulation of cytoskeleton organization 0 Highly Informative Direct
Biological Process (BP) chemotaxis 0 Highly Informative Direct
Biological Process (BP) actin filament organization 0.000000000000007248 Highly Informative Direct
Biological Process (BP) muscle organ development 0.00000000000002422 Highly Informative Direct
Biological Process (BP) cell junction organization 0.0000000000005554 Highly Informative Direct
Biological Process (BP) positive regulation of growth 0.0000000000008693 Highly Informative Direct
Biological Process (BP) regulation of microtubule polymerization or depolymerization 0.000000000002734 Highly Informative Direct
Biological Process (BP) positive regulation of neurogenesis 0.0000000003792 Highly Informative Direct
Biological Process (BP) maintenance of location 0.000000001191 Highly Informative Direct
Biological Process (BP) cell recognition 0.000000001774 Highly Informative Direct
Biological Process (BP) cellular component disassembly 0.000000002743 Highly Informative Direct
Biological Process (BP) female gamete generation 0.0000001784 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 0.0000002599 Highly Informative Direct
Biological Process (BP) post-embryonic organ development 0.0000006251 Highly Informative Direct
Biological Process (BP) positive regulation of cellular component biogenesis 0.0000007412 Highly Informative Direct
Biological Process (BP) cell adhesion 0.000002561 Highly Informative Direct
Biological Process (BP) plasma membrane organization 0.000004644 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.0000296 Highly Informative Direct
Biological Process (BP) positive regulation of GTPase activity 0.00004685 Highly Informative Direct
Biological Process (BP) locomotory behavior 0.00005681 Highly Informative Direct
Biological Process (BP) negative regulation of homeostatic process 0.00008841 Highly Informative Direct
Biological Process (BP) sensory perception 0.0001805 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 0.0002269 Highly Informative Direct
Biological Process (BP) wound healing 0.0003099 Highly Informative Direct
Biological Process (BP) protein polymerization 0.0003683 Highly Informative Direct
Biological Process (BP) regulation of myeloid cell differentiation 0.0003702 Highly Informative Direct
Biological Process (BP) regulation of Rho protein signal transduction 0.000401 Highly Informative Direct
Biological Process (BP) leukocyte migration 0.0004105 Highly Informative Direct
Biological Process (BP) regulation of multicellular organism growth 0.0004689 Highly Informative Direct
Biological Process (BP) cytokinesis 0.0005438 Highly Informative Direct
Biological Process (BP) nucleus organization 0.0005844 Highly Informative Direct
Biological Process (BP) negative regulation of protein catabolic process 0.0007569 Highly Informative Direct
Biological Process (BP) regulation of transmembrane transporter activity 0.0015 Highly Informative Inherited
Biological Process (BP) regulation of ion transmembrane transport 0.1197 Highly Informative Inherited
Biological Process (BP) epithelial cell development 0.1029 Highly Informative Inherited
Biological Process (BP) kidney development 1 Highly Informative Inherited
Biological Process (BP) spindle organization 0.2922 Highly Informative Inherited
Biological Process (BP) regulation of endocytosis 1 Highly Informative Inherited
Biological Process (BP) neuron projection development 0.02241 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.03319 Highly Informative Inherited
Biological Process (BP) regulation of cell size 0.02812 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0.4887 Highly Informative Inherited
Biological Process (BP) regulation of protein targeting 0.5948 Highly Informative Inherited
Biological Process (BP) regulation of nucleocytoplasmic transport 0.2657 Highly Informative Inherited
Biological Process (BP) regulation of protein localization to nucleus 0.02591 Highly Informative Inherited
Biological Process (BP) respiratory system development 0.002766 Highly Informative Inherited
Biological Process (BP) branching morphogenesis of an epithelial tube 0.008019 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.001026 Highly Informative Inherited
Biological Process (BP) regulation of Ras GTPase activity 0.009918 Highly Informative Inherited
Biological Process (BP) regulation of protein complex assembly 0.2356 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.006703 Highly Informative Inherited
Biological Process (BP) cell projection assembly 0.05917 Highly Informative Inherited
Biological Process (BP) cell projection morphogenesis 0.9246 Highly Informative Inherited
Biological Process (BP) positive regulation of transcription, DNA-templated 1 Highly Informative Inherited
Biological Process (BP) actomyosin structure organization 1 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.009814 Highly Informative Inherited
Biological Process (BP) germ cell development 0.2915 Highly Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 0.06986 Highly Informative Inherited
Biological Process (BP) protein import 0.3378 Highly Informative Inherited
Biological Process (BP) protein targeting to nucleus 0.8678 Highly Informative Inherited
Biological Process (BP) single-organism nuclear import 0.8921 Highly Informative Inherited
Biological Process (BP) protein phosphorylation 1 Highly Informative Inherited
Biological Process (BP) protein localization to membrane 0.0485 Highly Informative Inherited
Biological Process (BP) regulation of blood pressure 0.01623 Highly Informative Inherited
Biological Process (BP) pattern specification process 1 Highly Informative Inherited
Biological Process (BP) heart morphogenesis 0.3219 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 1 Highly Informative Inherited
Biological Process (BP) cell fate commitment 0.3985 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) anion binding 0.0000978 Moderately Informative Direct
Molecular Function (MF) small molecule binding 1 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity 0.8566 Moderately Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 1 Moderately Informative Inherited
Molecular Function (MF) structural molecule activity 0.006617 Moderately Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0 Informative Direct
Molecular Function (MF) protein complex binding 0 Informative Direct
Molecular Function (MF) cofactor binding 0.004061 Informative Inherited
Molecular Function (MF) nucleotide binding 0.04693 Informative Inherited
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) enzyme binding 0.01726 Informative Inherited
Molecular Function (MF) sulfur compound binding 0.04274 Informative Inherited
Molecular Function (MF) actin filament binding 0.000000000189 Highly Informative Direct
Molecular Function (MF) Ras GTPase binding 0 Highly Informative Direct
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0.00000000000001943 Highly Informative Direct
Molecular Function (MF) monooxygenase activity 0.0000000001744 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 0.00000004141 Highly Informative Direct
Molecular Function (MF) heparin binding 0.0004015 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0.4571 Highly Informative Inherited
Molecular Function (MF) kinase binding 0.1252 Highly Informative Inherited
Molecular Function (MF) tubulin binding 0.255 Highly Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0 Least Informative Direct
Cellular Component (CC) protein complex 0.00000001077 Least Informative Direct
Cellular Component (CC) membrane 0.01949 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0 Moderately Informative Direct
Cellular Component (CC) membrane region 0.000005952 Moderately Informative Direct
Cellular Component (CC) plasma membrane part 0.00003807 Moderately Informative Direct
Cellular Component (CC) intrinsic component of membrane 1 Moderately Informative Inherited
Cellular Component (CC) bounding membrane of organelle 1 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 0.07764 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) extracellular region part 0.4099 Moderately Informative Inherited
Cellular Component (CC) contractile fiber part 0 Informative Direct
Cellular Component (CC) cell cortex 0 Informative Direct
Cellular Component (CC) nuclear envelope 0 Informative Direct
Cellular Component (CC) actin cytoskeleton 0 Informative Direct
Cellular Component (CC) cell junction 0 Informative Direct
Cellular Component (CC) cell leading edge 0 Informative Direct
Cellular Component (CC) synapse 0.0000001521 Informative Direct
Cellular Component (CC) plasma membrane region 0.0000004184 Informative Direct
Cellular Component (CC) endosome 0.7711 Informative Inherited
Cellular Component (CC) neuron projection 0.5329 Informative Inherited
Cellular Component (CC) integral component of membrane 1 Informative Inherited
Cellular Component (CC) intrinsic component of plasma membrane 1 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 0.5434 Informative Inherited
Cellular Component (CC) extracellular matrix 0.06685 Informative Inherited
Cellular Component (CC) cortical cytoskeleton 0.00000001389 Highly Informative Direct
Cellular Component (CC) adherens junction 0 Highly Informative Direct
Cellular Component (CC) nuclear membrane 0.000000000000003071 Highly Informative Direct
Cellular Component (CC) growth cone 0.000000000000003071 Highly Informative Direct
Cellular Component (CC) apical plasma membrane 0.00000000003 Highly Informative Direct
Cellular Component (CC) cell division site part 0.00003042 Highly Informative Direct
Cellular Component (CC) spindle 0.00003696 Highly Informative Direct
Cellular Component (CC) endosomal part 0.528 Highly Informative Inherited
Cellular Component (CC) cell body 0.3672 Highly Informative Inherited
Cellular Component (CC) basolateral plasma membrane 0.001009 Highly Informative Inherited
Cellular Component (CC) receptor complex 0.4915 Highly Informative Inherited
Cellular Component (CC) integral component of plasma membrane 1 Highly Informative Inherited
Cellular Component (CC) intermediate filament cytoskeleton 0.2671 Highly Informative Inherited
Cellular Component (CC) organelle outer membrane 0.004029 Highly Informative Inherited
Cellular Component (CC) proteinaceous extracellular matrix 0.003833 Highly Informative Inherited

Document: GO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.2591Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle physiology0.269Moderately InformativeInherited
Phenotypic Abnormality (PA)Proximal muscle weakness0.00007795InformativeDirect
Phenotypic Abnormality (PA)Abnormality of circulating enzyme level0.0002844InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.09113Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.7508Least InformativeInherited
Mammalian Phenotype (MP)muscle phenotype0.0006042Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal metabolism0.05005Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.2181Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal systemic arterial blood pressure0.1044InformativeInherited
Mammalian Phenotype (MP)abnormal exercise endurance0.0000422Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.001041Least InformativeInherited
Worm Phenotype (WP)locomotion variant0.0003113Moderately InformativeDirect
Worm Phenotype (WP)early embryonic lethal0.005971Moderately InformativeInherited
Worm Phenotype (WP)organ system development variant0.006891Moderately InformativeInherited
Worm Phenotype (WP)brood size variant0.0000009212InformativeDirect
Worm Phenotype (WP)body wall muscle morphology variant0.000001303InformativeDirect
Worm Phenotype (WP)exploded through vulva0.0002208InformativeDirect
Worm Phenotype (WP)cell division variant0.1266InformativeInherited
Worm Phenotype (WP)body wall muscle myosin organization defective0.00003592Highly InformativeDirect
Worm Phenotype (WP)cleavage furrow defective early emb0.00004908Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)cell0.1312Least InformativeInherited
Fly Anatomy (FA)adult0.1406Least InformativeInherited
Fly Anatomy (FA)organ system0.3767Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)adult segment0.07047Moderately InformativeInherited
Fly Anatomy (FA)adult thorax0.3926Moderately InformativeInherited
Fly Anatomy (FA)thoracic segment0.9229Moderately InformativeInherited
Fly Anatomy (FA)syncytium0.00876InformativeInherited
Fly Anatomy (FA)muscle system0.009009InformativeInherited
Fly Anatomy (FA)muscle cell0.01784InformativeInherited

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)portion of tissue0.2378Least InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.0001405Moderately InformativeDirect
Xenopus ANatomical entity (XAN)skeletal system0.0008294InformativeDirect
Xenopus ANatomical entity (XAN)bone tissue0.0001534Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCell cycle0Moderately InformativeDirect
Biological processMitosis0InformativeDirect
Biological processAngiogenesis0.000000005722InformativeDirect
Biological processCell adhesion0.0000002624InformativeDirect
Biological processWnt signaling pathway0.0000006339InformativeDirect
Biological processEndocytosis0.00002194InformativeDirect
Biological processExocytosis0.00000008649Highly InformativeDirect
Biological processCilium biogenesis/degradation0.0000001766Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentNucleus0.00000192Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentEndosome0.00007575Moderately InformativeDirect
Cellular componentMicrotubule0InformativeDirect
Cellular componentSynapse1InformativeInherited
Cellular componentPostsynaptic cell membrane0.000001721Highly InformativeDirect
Coding sequence diversityAlternative splicing0.0003726Least InformativeDirect
DomainRepeat0Least InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
DomainSH3 domain0.000000000000003027InformativeDirect
DomainSH2 domain0.00000001582InformativeDirect
DomainLeucine-rich repeat0.0002789InformativeDirect
DomainLIM domain0Highly InformativeDirect
Molecular functionZinc0.0000006086Least InformativeDirect
Molecular functionMetal-binding0.0006987Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionFlavoprotein0.00003302Moderately InformativeDirect
Molecular functionActin-binding0InformativeDirect
Molecular functionCalmodulin-binding0InformativeDirect
Molecular functionFAD0.0000001671InformativeDirect
Post-translational modificationOxidoreductase1Moderately InformativeInherited
Post-translational modificationGuanine-nucleotide releasing factor0InformativeDirect
Post-translational modificationActin capping0Highly InformativeDirect
Post-translational modificationMuscle protein0.000000000006613Highly InformativeDirect
Post-translational modificationMonooxygenase0.000000000007208Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationAcetylation0.0000000687Least InformativeDirect

Document: KW annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 17 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Calponin-homology domain, CH-domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 17 hidden Markov models representing the Calponin-homology domain, CH-domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]