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Calponin-homology domain, CH-domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   CH domain-like [ 47575] (3)
Superfamily:   Calponin-homology domain, CH-domain [ 47576]
Families:   Calponin-homology domain, CH-domain [ 47577] (9)


Superfamily statistics
Genomes (507) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 12,765 32,034 21
Proteins 12,503 31,474 21


Functional annotation
General category General
Detailed category General

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism cellular process0.36550Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.086170Least InformativeInherited
Biological Process (BP)biological regulation0.095450.001075Least InformativeInherited
Biological Process (BP)multicellular organismal process0.0079590Least InformativeInherited
Biological Process (BP)regulation of cellular component organization0.002620Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.18370.004938Moderately InformativeInherited
Biological Process (BP)animal organ development0.35530.00004446Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular component organization0.000035470InformativeDirect
Biological Process (BP)supramolecular fiber organization0.00046880InformativeDirect
Biological Process (BP)regulation of organelle organization0.035640.000000000125InformativeInherited
Biological Process (BP)muscle organ development0.00099010Highly InformativeDirect
Biological Process (BP)regulation of microtubule-based process0.000000019640Highly InformativeDirect
Biological Process (BP)regulation of protein complex disassembly0.0000039250Highly InformativeDirect
Biological Process (BP)negative regulation of cytoskeleton organization0.000000011770Highly InformativeDirect
Biological Process (BP)negative regulation of supramolecular fiber organization0.000000008910Highly InformativeDirect
Molecular Function (MF)binding0.00076570Least InformativeDirect
Molecular Function (MF)cytoskeletal protein binding7.1e-160InformativeDirect
Molecular Function (MF)tubulin binding0.29650.5916Highly InformativeInherited
Cellular Component (CC)non-membrane-bounded organelle0.00000013570Least InformativeDirect
Cellular Component (CC)intracellular organelle part0.085460Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.4910.0006526Least InformativeInherited
Cellular Component (CC)cell projection0.00079770Moderately InformativeDirect
Cellular Component (CC)cytoskeleton0.003250Moderately InformativeInherited
Cellular Component (CC)supramolecular polymer0.0000009050InformativeDirect
Cellular Component (CC)cytoplasmic region0.00011160InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) biological regulation 0.001075 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) organelle organization 0 Moderately Informative Direct
Biological Process (BP) response to external stimulus 0.000001143 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.0000000001167 Moderately Informative Direct
Biological Process (BP) tissue development 0 Moderately Informative Direct
Biological Process (BP) cellular component assembly 0.000001454 Moderately Informative Direct
Biological Process (BP) animal organ development 0.00004446 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.00003453 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.0000115 Moderately Informative Direct
Biological Process (BP) cellular localization 0.000000003059 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.000000001308 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.0488 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.8124 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.9712 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.3929 Moderately Informative Inherited
Biological Process (BP) protein complex biogenesis 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.9402 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.116 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.01066 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.6023 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.1771 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.004938 Moderately Informative Inherited
Biological Process (BP) reproduction 0.02621 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.127 Moderately Informative Inherited
Biological Process (BP) oxidation-reduction process 0.01437 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) cell communication 0.07284 Moderately Informative Inherited
Biological Process (BP) single organism signaling 1 Moderately Informative Inherited
Biological Process (BP) movement of cell or subcellular component 0.000003493 Informative Direct
Biological Process (BP) microtubule-based process 0 Informative Direct
Biological Process (BP) behavior 0.00000005874 Informative Direct
Biological Process (BP) response to wounding 0.000002237 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.0000003376 Informative Direct
Biological Process (BP) cell cycle process 0.0006281 Informative Direct
Biological Process (BP) actin cytoskeleton organization 0 Informative Direct
Biological Process (BP) cellular component morphogenesis 0 Informative Direct
Biological Process (BP) regulation of organelle organization 0.000000000125 Informative Direct
Biological Process (BP) regulation of growth 0.00000000000001422 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) regulation of locomotion 0.0003394 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.00000000000006022 Informative Direct
Biological Process (BP) multi-organism reproductive process 0.000008574 Informative Direct
Biological Process (BP) single-organism membrane organization 0.0001414 Informative Direct
Biological Process (BP) regulation of cell differentiation 0.00001003 Informative Direct
Biological Process (BP) intracellular transport 0.0001899 Informative Direct
Biological Process (BP) cell development 0 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0 Informative Direct
Biological Process (BP) positive regulation of developmental process 0.00000004034 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.0003492 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0.00002063 Informative Direct
Biological Process (BP) regulation of nervous system development 0.0001143 Informative Direct
Biological Process (BP) organelle assembly 0 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0 Informative Direct
Biological Process (BP) supramolecular fiber organization 0 Informative Direct
Biological Process (BP) regulation of transmembrane transport 0.02701 Informative Inherited
Biological Process (BP) regulation of ion transport 0.008896 Informative Inherited
Biological Process (BP) cellular response to hormone stimulus 0.01028 Informative Inherited
Biological Process (BP) protein localization to organelle 0.6935 Informative Inherited
Biological Process (BP) circulatory system development 1 Informative Inherited
Biological Process (BP) reproductive system development 1 Informative Inherited
Biological Process (BP) organelle localization 0.1037 Informative Inherited
Biological Process (BP) cellular protein complex assembly 0.07917 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.005303 Informative Inherited
Biological Process (BP) generation of neurons 0.06248 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.6537 Informative Inherited
Biological Process (BP) regulation of protein localization 0.9736 Informative Inherited
Biological Process (BP) positive regulation of transport 0.834 Informative Inherited
Biological Process (BP) regulation of cellular localization 0.2251 Informative Inherited
Biological Process (BP) regulation of peptide transport 0.9148 Informative Inherited
Biological Process (BP) regulation of protein modification process 0.08556 Informative Inherited
Biological Process (BP) regulation of phosphorylation 0.1067 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.02666 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.05154 Informative Inherited
Biological Process (BP) cell activation 1 Informative Inherited
Biological Process (BP) central nervous system development 0.3715 Informative Inherited
Biological Process (BP) system process 1 Informative Inherited
Biological Process (BP) regulation of system process 0.003373 Informative Inherited
Biological Process (BP) single-organism cellular localization 0.01762 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 1 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 1 Informative Inherited
Biological Process (BP) positive regulation of gene expression 1 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 1 Informative Inherited
Biological Process (BP) response to extracellular stimulus 0.8023 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.3476 Informative Inherited
Biological Process (BP) post-embryonic development 0.004205 Informative Inherited
Biological Process (BP) single organism reproductive process 0.8595 Informative Inherited
Biological Process (BP) multicellular organism reproduction 1 Informative Inherited
Biological Process (BP) regulation of cell cycle 0.7901 Informative Inherited
Biological Process (BP) DNA metabolic process 1 Informative Inherited
Biological Process (BP) embryo development 1 Informative Inherited
Biological Process (BP) regulation of cell growth 0.00001126 Highly Informative Direct
Biological Process (BP) female gamete generation 0.00000002898 Highly Informative Direct
Biological Process (BP) muscle organ development 0 Highly Informative Direct
Biological Process (BP) hemostasis 0.0005484 Highly Informative Direct
Biological Process (BP) locomotory behavior 0.0000000001454 Highly Informative Direct
Biological Process (BP) positive regulation of cell development 0.00000000000006667 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.0000007728 Highly Informative Direct
Biological Process (BP) cellular component assembly involved in morphogenesis 0 Highly Informative Direct
Biological Process (BP) cellular component disassembly 0.00009508 Highly Informative Direct
Biological Process (BP) biological adhesion 0.000002333 Highly Informative Direct
Biological Process (BP) actomyosin structure organization 0.000003425 Highly Informative Direct
Biological Process (BP) negative regulation of homeostatic process 0.00001185 Highly Informative Direct
Biological Process (BP) regulation of microtubule-based process 0 Highly Informative Direct
Biological Process (BP) positive regulation of transmembrane transport 0.0002752 Highly Informative Direct
Biological Process (BP) wound healing 0.000224 Highly Informative Direct
Biological Process (BP) regulation of protein complex disassembly 0 Highly Informative Direct
Biological Process (BP) positive regulation of cellular component biogenesis 0.0000000009533 Highly Informative Direct
Biological Process (BP) DNA methylation or demethylation 0.000002601 Highly Informative Direct
Biological Process (BP) positive regulation of growth 0 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 0.0000000000004409 Highly Informative Direct
Biological Process (BP) protein polymerization 0.0007866 Highly Informative Direct
Biological Process (BP) negative regulation of cytoskeleton organization 0 Highly Informative Direct
Biological Process (BP) establishment of organelle localization 0.000005518 Highly Informative Direct
Biological Process (BP) positive regulation of nervous system development 0.0000000002385 Highly Informative Direct
Biological Process (BP) striated muscle cell development 0.000000001083 Highly Informative Direct
Biological Process (BP) muscle tissue development 0 Highly Informative Direct
Biological Process (BP) plasma membrane bounded cell projection organization 0 Highly Informative Direct
Biological Process (BP) negative regulation of supramolecular fiber organization 0 Highly Informative Direct
Biological Process (BP) regulation of cation transmembrane transport 0.0009093 Highly Informative Direct
Biological Process (BP) regulation of hemopoiesis 0.01147 Highly Informative Inherited
Biological Process (BP) protein localization to membrane 0.002511 Highly Informative Inherited
Biological Process (BP) epithelial cell differentiation 0.9446 Highly Informative Inherited
Biological Process (BP) kidney development 1 Highly Informative Inherited
Biological Process (BP) cytokinesis 0.2876 Highly Informative Inherited
Biological Process (BP) regulation of cell size 0.009996 Highly Informative Inherited
Biological Process (BP) actin filament organization 0.9386 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.01077 Highly Informative Inherited
Biological Process (BP) neuron development 1 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.02668 Highly Informative Inherited
Biological Process (BP) anatomical structure homeostasis 0.004444 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.02451 Highly Informative Inherited
Biological Process (BP) maintenance of location 0.001142 Highly Informative Inherited
Biological Process (BP) cell maturation 1 Highly Informative Inherited
Biological Process (BP) anatomical structure maturation 0.584 Highly Informative Inherited
Biological Process (BP) regulation of intracellular protein transport 0.01929 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.0036 Highly Informative Inherited
Biological Process (BP) positive regulation of protein transport 0.1418 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular protein localization 0.005994 Highly Informative Inherited
Biological Process (BP) regulation of nucleocytoplasmic transport 0.4448 Highly Informative Inherited
Biological Process (BP) regulation of protein localization to nucleus 0.6999 Highly Informative Inherited
Biological Process (BP) regulation of protein import 0.02861 Highly Informative Inherited
Biological Process (BP) tube morphogenesis 0.01692 Highly Informative Inherited
Biological Process (BP) appendage development 0.0312 Highly Informative Inherited
Biological Process (BP) microtubule cytoskeleton organization 0.9691 Highly Informative Inherited
Biological Process (BP) negative regulation of protein complex assembly 0.2432 Highly Informative Inherited
Biological Process (BP) regulation of protein polymerization 0.01232 Highly Informative Inherited
Biological Process (BP) cellular response to extracellular stimulus 0.00391 Highly Informative Inherited
Biological Process (BP) coagulation 0.1448 Highly Informative Inherited
Biological Process (BP) cell projection assembly 0.8423 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 1 Highly Informative Inherited
Biological Process (BP) cell-cell signaling 0.003654 Highly Informative Inherited
Biological Process (BP) positive regulation of transcription from RNA polymerase II promoter 1 Highly Informative Inherited
Biological Process (BP) response to nutrient levels 0.01054 Highly Informative Inherited
Biological Process (BP) germ cell development 1 Highly Informative Inherited
Biological Process (BP) post-embryonic animal morphogenesis 0.001435 Highly Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 0.6335 Highly Informative Inherited
Biological Process (BP) endomembrane system organization 0.04665 Highly Informative Inherited
Biological Process (BP) muscle system process 0.03652 Highly Informative Inherited
Biological Process (BP) macromolecule methylation 0.02518 Highly Informative Inherited
Biological Process (BP) nervous system process 0.7886 Highly Informative Inherited
Biological Process (BP) regulation of blood pressure 0.008444 Highly Informative Inherited
Biological Process (BP) heart development 1 Highly Informative Inherited
Biological Process (BP) embryonic organ development 1 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) anion binding 0.001375 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 1 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 1 Moderately Informative Inherited
Molecular Function (MF) structural molecule activity 0.03307 Moderately Informative Inherited
Molecular Function (MF) molecular function regulator 0.01277 Moderately Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0 Informative Direct
Molecular Function (MF) identical protein binding 0.00000001189 Informative Direct
Molecular Function (MF) macromolecular complex binding 0 Informative Direct
Molecular Function (MF) protein dimerization activity 0.00000000006277 Informative Direct
Molecular Function (MF) coenzyme binding 0.0000006843 Informative Direct
Molecular Function (MF) enzyme binding 0.9352 Informative Inherited
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) sulfur compound binding 0.1014 Informative Inherited
Molecular Function (MF) monooxygenase activity 0.00000003839 Highly Informative Direct
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0.00000009363 Highly Informative Direct
Molecular Function (MF) heparin binding 0.0002809 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 0.0000008007 Highly Informative Direct
Molecular Function (MF) protein homodimerization activity 0 Highly Informative Direct
Molecular Function (MF) cell adhesion molecule binding 0.000499 Highly Informative Direct
Molecular Function (MF) actin filament binding 0.00000004392 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0.7098 Highly Informative Inherited
Molecular Function (MF) transcription factor activity, transcription factor binding 0.2689 Highly Informative Inherited
Molecular Function (MF) small GTPase binding 0.6787 Highly Informative Inherited
Molecular Function (MF) tubulin binding 0.5916 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.0006526 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0 Least Informative Direct
Cellular Component (CC) protein complex 0.00337 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoskeleton 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) endomembrane system 1 Moderately Informative Inherited
Cellular Component (CC) vesicle 0.03339 Moderately Informative Inherited
Cellular Component (CC) membrane protein complex 0.2809 Moderately Informative Inherited
Cellular Component (CC) intrinsic component of membrane 1 Moderately Informative Inherited
Cellular Component (CC) bounding membrane of organelle 0.2714 Moderately Informative Inherited
Cellular Component (CC) whole membrane 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) extracellular region part 0.8322 Moderately Informative Inherited
Cellular Component (CC) nuclear envelope 0.00000001813 Informative Direct
Cellular Component (CC) actin cytoskeleton 0 Informative Direct
Cellular Component (CC) apical part of cell 0.000000000522 Informative Direct
Cellular Component (CC) plasma membrane region 0.000081 Informative Direct
Cellular Component (CC) plasma membrane protein complex 0.0002709 Informative Direct
Cellular Component (CC) supramolecular polymer 0 Informative Direct
Cellular Component (CC) cytoplasmic region 0 Informative Direct
Cellular Component (CC) endosome 0.6609 Informative Inherited
Cellular Component (CC) neuron projection 1 Informative Inherited
Cellular Component (CC) plasma membrane bounded cell projection part 1 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) outer membrane 0.04605 Informative Inherited
Cellular Component (CC) spindle 0.000001238 Highly Informative Direct
Cellular Component (CC) cytoplasmic microtubule 0 Highly Informative Direct
Cellular Component (CC) cell-substrate adherens junction 0.0000000376 Highly Informative Direct
Cellular Component (CC) apical plasma membrane 0.00009044 Highly Informative Direct
Cellular Component (CC) lamellipodium 0 Highly Informative Direct
Cellular Component (CC) growth cone 0 Highly Informative Direct
Cellular Component (CC) cortical cytoskeleton 0 Highly Informative Direct
Cellular Component (CC) nuclear membrane 0.000000001896 Highly Informative Direct
Cellular Component (CC) cell division site part 0.00001725 Highly Informative Direct
Cellular Component (CC) receptor complex 0.0008056 Highly Informative Direct
Cellular Component (CC) basal part of cell 0.0000000004225 Highly Informative Direct
Cellular Component (CC) contractile ring 0.0000000002035 Highly Informative Direct
Cellular Component (CC) neuronal cell body 1 Highly Informative Inherited
Cellular Component (CC) basolateral plasma membrane 0.3298 Highly Informative Inherited
Cellular Component (CC) intrinsic component of plasma membrane 1 Highly Informative Inherited
Cellular Component (CC) cell-cell junction 1 Highly Informative Inherited

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCell cycle0Moderately InformativeDirect
Biological processMitosis0InformativeDirect
Biological processAngiogenesis0.00000001274InformativeDirect
Biological processEndocytosis0.0000002216InformativeDirect
Biological processCell adhesion0.0000006583InformativeDirect
Biological processWnt signaling pathway0.000001148InformativeDirect
Biological processExocytosis0.0000002005Highly InformativeDirect
Biological processCilium biogenesis/degradation0.00000143Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentNucleus0.00006012Least InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentEndosome0.0000003353Moderately InformativeDirect
Cellular componentMicrotubule0InformativeDirect
Cellular componentSynapse1InformativeInherited
Cellular componentPostsynaptic cell membrane0.0000003441Highly InformativeDirect
Coding sequence diversityAlternative splicing0.0002169Least InformativeDirect
DomainRepeat0Least InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
DomainSH3 domain0.00000000000001274InformativeDirect
DomainSH2 domain0.00000002947InformativeDirect
DomainLeucine-rich repeat0.0006484InformativeDirect
DomainLIM domain0Highly InformativeDirect
Molecular functionZinc0.000005549Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionFlavoprotein0.0002539Moderately InformativeDirect
Molecular functionFAD0.000002699InformativeDirect
Post-translational modificationOxidoreductase1Moderately InformativeInherited
Post-translational modificationActin-binding0InformativeDirect
Post-translational modificationCalmodulin-binding0InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor0InformativeDirect
Post-translational modificationActin capping4.406e-16Highly InformativeDirect
Post-translational modificationMuscle protein0.00000000001445Highly InformativeDirect
Post-translational modificationMonooxygenase0.00000000007887Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationAcetylation0.000000000004653Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 17 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Calponin-homology domain, CH-domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 17 hidden Markov models representing the Calponin-homology domain, CH-domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]