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Calponin-homology domain, CH-domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   CH domain-like [ 47575] (3)
Superfamily:   Calponin-homology domain, CH-domain [ 47576]
Families:   Calponin-homology domain, CH-domain [ 47577] (9)


Superfamily statistics
Genomes (509) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 12,940 0 21
Proteins 12,673 0 21


Functional annotation
General category General
Detailed category General

Document:
Function annotation of SCOP domain superfamilies

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.09723Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature0.1698Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of circulating protein level0.00309InformativeInherited
Phenotypic Abnormality (PA)Muscle weakness0.3513InformativeInherited
Phenotypic Abnormality (PA)Proximal muscle weakness0.0003372Highly InformativeDirect
Phenotypic Abnormality (PA)Elevated serum creatine phosphokinase0.0005301Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.1196Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.5389Least InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.02426Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.1102Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.3984Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.4632Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.7021Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.7829Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mature B cell morphology0.1097InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation0.318InformativeInherited
Mammalian Phenotype (MP)abnormal intestine morphology0.3477InformativeInherited
Mammalian Phenotype (MP)increased leukocyte cell number0.6737InformativeInherited
Mammalian Phenotype (MP)abnormal exercise endurance0.0001406Highly InformativeDirect
Mammalian Phenotype (MP)abnormal transitional stage T1 B cell morphology0.000161Highly InformativeDirect
Mammalian Phenotype (MP)abnormal transitional stage T2 B cell morphology0.0002205Highly InformativeDirect
Mammalian Phenotype (MP)intestinal ulcer0.0008045Highly InformativeDirect
Mammalian Phenotype (MP)decreased immature B cell number0.1487Highly InformativeInherited
Mammalian Phenotype (MP)increased B cell number0.2536Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell morphology variant0.0000002853Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.0000504Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.0006164Least InformativeDirect
Worm Phenotype (WP)cell development variant0.05002Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.1961Least InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.001836Moderately InformativeInherited
Worm Phenotype (WP)metabolic pathway variant0.006742Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.468Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.5342Moderately InformativeInherited
Worm Phenotype (WP)reduced brood size0.0000002561InformativeDirect
Worm Phenotype (WP)protein degradation variant0.00005151InformativeDirect
Worm Phenotype (WP)muscle cell physiology variant0.00008751InformativeDirect
Worm Phenotype (WP)cytokinesis variant emb0.0001557InformativeDirect
Worm Phenotype (WP)neuronal outgrowth variant0.0005395InformativeDirect
Worm Phenotype (WP)epithelial system development variant0.05053InformativeInherited
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.6843InformativeInherited
Worm Phenotype (WP)cleavage furrow defective0.000003438Highly InformativeDirect
Worm Phenotype (WP)axon guidance variant0.0001478Highly InformativeDirect
Worm Phenotype (WP)exploded through vulva0.0003342Highly InformativeDirect
Worm Phenotype (WP)cytokinesis defective early emb0.007031Highly InformativeInherited
Worm Phenotype (WP)body wall muscle thick filament variant0.1996Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)somatic cell0.06059Least InformativeInherited
Fly Anatomy (FA)adult0.07056Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)adult segment0.1926Moderately InformativeInherited
Fly Anatomy (FA)adult thorax0.4965Moderately InformativeInherited
Fly Anatomy (FA)thoracic segment0.9319Moderately InformativeInherited
Fly Anatomy (FA)muscle system0.002454InformativeInherited
Fly Anatomy (FA)syncytium0.003093InformativeInherited
Fly Anatomy (FA)flight muscle0.0002911Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0.00000000000001354Least InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation of one atom of oxygen0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCell cycle0Moderately InformativeDirect
Biological processMitosis0InformativeDirect
Biological processAngiogenesis0.00000001428InformativeDirect
Biological processEndocytosis0.0000002436InformativeDirect
Biological processCell adhesion0.000000662InformativeDirect
Biological processWnt signaling pathway0.000001224InformativeDirect
Biological processExocytosis0.0000001994Highly InformativeDirect
Biological processCilium biogenesis/degradation0.00000185Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentNucleus0.00002796Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentEndosome0.0000006862Moderately InformativeDirect
Cellular componentMicrotubule0InformativeDirect
Cellular componentSynapse1InformativeInherited
Cellular componentPostsynaptic cell membrane0.0000004443Highly InformativeDirect
Coding sequence diversityAlternative splicing0.000161Least InformativeDirect
DomainRepeat0Least InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
DomainSH3 domain0InformativeDirect
DomainSH2 domain0.0000000431InformativeDirect
DomainLIM domain0Highly InformativeDirect
Molecular functionZinc0.000008805Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionFlavoprotein0.0002804Moderately InformativeDirect
Molecular functionFAD0.000003096InformativeDirect
Post-translational modificationOxidoreductase1Moderately InformativeInherited
Post-translational modificationActin-binding0InformativeDirect
Post-translational modificationCalmodulin-binding0InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor0InformativeDirect
Post-translational modificationActin capping4.464e-16Highly InformativeDirect
Post-translational modificationMuscle protein0.00000000001607Highly InformativeDirect
Post-translational modificationMonooxygenase0.0000000001299Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationAcetylation0.00000000002797Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 17 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Calponin-homology domain, CH-domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 17 hidden Markov models representing the Calponin-homology domain, CH-domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]