SUPERFAMILY 1.75 HMM library and genome assignments server


Calponin-homology domain, CH-domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   CH domain-like [ 47575] (3)
Superfamily:   Calponin-homology domain, CH-domain [ 47576]
Families:   Calponin-homology domain, CH-domain [ 47577] (9)


Superfamily statistics
Genomes (446) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 11,144 10,185 21
Proteins 10,923 10,032 21


Functional annotation
General category General
Detailed category General

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)localization0.12060Least InformativeInherited
Biological Process (BP)single-organism cellular process0.070770Least InformativeInherited
Biological Process (BP)macromolecule localization0.001060.0001607Moderately InformativeInherited
Biological Process (BP)establishment or maintenance of cell polarity7.434e-051.494e-10Highly InformativeDirect
Molecular Function (MF)binding0.0066110Least InformativeInherited
Molecular Function (MF)protein binding6.165e-050Moderately InformativeDirect
Molecular Function (MF)cytoskeletal protein binding4.76e-140InformativeDirect
Cellular Component (CC)intracellular non-membrane-bounded organelle0.00015540Least InformativeDirect
Cellular Component (CC)cytoplasmic part0.51290.7683Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.0085213.213e-07Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)cell projection4.429e-050Moderately InformativeDirect
Cellular Component (CC)cytoskeleton0.010720Moderately InformativeInherited
Cellular Component (CC)endomembrane system0.026390.07921Moderately InformativeInherited
Cellular Component (CC)organelle envelope0.095510.09484Moderately InformativeInherited
Cellular Component (CC)nuclear part0.47771Moderately InformativeInherited
Cellular Component (CC)contractile fiber part2.072e-080InformativeDirect
Cellular Component (CC)cell cortex5.966e-070InformativeDirect
Cellular Component (CC)cell projection part2.857e-059.002e-14InformativeDirect
Cellular Component (CC)nuclear envelope0.00017.342e-11InformativeDirect
Cellular Component (CC)cortical cytoskeleton0.00016961.442e-10Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.1129 Least Informative Inherited
Biological Process (BP) response to stimulus 0.01334 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) macromolecule localization 0.0001607 Moderately Informative Direct
Biological Process (BP) cellular localization 5.837e-13 Moderately Informative Direct
Biological Process (BP) organelle organization 0 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 7.299e-09 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 8.345e-05 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.1865 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.0118 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.05117 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.03648 Moderately Informative Inherited
Biological Process (BP) homeostatic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.1741 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.829 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.654 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.1329 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.07306 Moderately Informative Inherited
Biological Process (BP) organ development 0.7151 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.008534 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.1685 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.6625 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.9126 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.7403 Moderately Informative Inherited
Biological Process (BP) reproduction 0.004369 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.9981 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) system process 0.9629 Moderately Informative Inherited
Biological Process (BP) cellular membrane organization 0.0007539 Informative Direct
Biological Process (BP) cellular component movement 6.697e-06 Informative Direct
Biological Process (BP) cytoskeleton organization 0 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0 Informative Direct
Biological Process (BP) microtubule-based process 0 Informative Direct
Biological Process (BP) actin filament-based process 0 Informative Direct
Biological Process (BP) locomotion 3.682e-14 Informative Direct
Biological Process (BP) muscle structure development 1.743e-13 Informative Direct
Biological Process (BP) regulation of anatomical structure size 1.114e-12 Informative Direct
Biological Process (BP) cell projection organization 4.959e-12 Informative Direct
Biological Process (BP) regulation of organelle organization 8.308e-12 Informative Direct
Biological Process (BP) response to external stimulus 1.286e-09 Informative Direct
Biological Process (BP) regulation of growth 1.764e-08 Informative Direct
Biological Process (BP) cellular component disassembly 4.125e-08 Informative Direct
Biological Process (BP) vesicle-mediated transport 2.494e-07 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 6.557e-06 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.000114 Informative Direct
Biological Process (BP) regulation of hydrolase activity 0.000153 Informative Direct
Biological Process (BP) positive regulation of signal transduction 0.000372 Informative Direct
Biological Process (BP) cell cycle process 0.0004011 Informative Direct
Biological Process (BP) generation of neurons 0.0004801 Informative Direct
Biological Process (BP) muscle system process 0.0006326 Informative Direct
Biological Process (BP) regulation of nervous system development 0.0006631 Informative Direct
Biological Process (BP) biological adhesion 0.0009243 Informative Direct
Biological Process (BP) cellular response to endogenous stimulus 0.4771 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.7253 Informative Inherited
Biological Process (BP) protein localization to organelle 0.1639 Informative Inherited
Biological Process (BP) epithelium development 0.4147 Informative Inherited
Biological Process (BP) regulation of system process 0.6533 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) reproductive system development 1 Informative Inherited
Biological Process (BP) organ morphogenesis 0.6785 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.001431 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.1234 Informative Inherited
Biological Process (BP) positive regulation of transport 0.4852 Informative Inherited
Biological Process (BP) anatomical structure homeostasis 0.07072 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.5126 Informative Inherited
Biological Process (BP) sensory organ development 0.07885 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.01357 Informative Inherited
Biological Process (BP) regulation of protein localization 0.7514 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.2985 Informative Inherited
Biological Process (BP) cell activation 0.02589 Informative Inherited
Biological Process (BP) response to wounding 0.006204 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.1802 Informative Inherited
Biological Process (BP) negative regulation of cellular metabolic process 1 Informative Inherited
Biological Process (BP) tube development 0.3489 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.3402 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.03706 Informative Inherited
Biological Process (BP) single-organism behavior 0.1296 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.2691 Informative Inherited
Biological Process (BP) central nervous system development 0.002306 Informative Inherited
Biological Process (BP) regulation of cell development 0.4418 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.007139 Informative Inherited
Biological Process (BP) localization of cell 0.2497 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.002636 Informative Inherited
Biological Process (BP) sexual reproduction 0.1141 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.7115 Informative Inherited
Biological Process (BP) single organism reproductive process 0.7999 Informative Inherited
Biological Process (BP) protein transport 0.04351 Informative Inherited
Biological Process (BP) nucleocytoplasmic transport 0.2831 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 1 Informative Inherited
Biological Process (BP) protein phosphorylation 0.9172 Informative Inherited
Biological Process (BP) regulation of ion transport 0.09401 Informative Inherited
Biological Process (BP) blood circulation 0.01677 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.8091 Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 1.494e-10 Highly Informative Direct
Biological Process (BP) negative regulation of cytoskeleton organization 0 Highly Informative Direct
Biological Process (BP) regulation of protein complex disassembly 0 Highly Informative Direct
Biological Process (BP) axonogenesis 0 Highly Informative Direct
Biological Process (BP) regulation of cellular component size 0 Highly Informative Direct
Biological Process (BP) cellular protein complex disassembly 0 Highly Informative Direct
Biological Process (BP) chemotaxis 1.391e-12 Highly Informative Direct
Biological Process (BP) regulation of neuron differentiation 1.363e-11 Highly Informative Direct
Biological Process (BP) muscle organ development 6.282e-11 Highly Informative Direct
Biological Process (BP) regulation of microtubule polymerization or depolymerization 1.49e-10 Highly Informative Direct
Biological Process (BP) regulation of purine nucleotide catabolic process 1.105e-09 Highly Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 2.356e-09 Highly Informative Direct
Biological Process (BP) cell division 4.084e-08 Highly Informative Direct
Biological Process (BP) actin filament organization 4.744e-08 Highly Informative Direct
Biological Process (BP) tube formation 9.467e-08 Highly Informative Direct
Biological Process (BP) maintenance of location 3.079e-07 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 3.468e-07 Highly Informative Direct
Biological Process (BP) wound healing 2.69e-06 Highly Informative Direct
Biological Process (BP) plasma membrane organization 3.034e-06 Highly Informative Direct
Biological Process (BP) regulation of sodium ion transport 7.512e-06 Highly Informative Direct
Biological Process (BP) endosomal transport 8.821e-06 Highly Informative Direct
Biological Process (BP) T cell activation 1.216e-05 Highly Informative Direct
Biological Process (BP) female gamete generation 2.152e-05 Highly Informative Direct
Biological Process (BP) post-embryonic organ development 8.613e-05 Highly Informative Direct
Biological Process (BP) regulation of myeloid cell differentiation 0.0001837 Highly Informative Direct
Biological Process (BP) morphogenesis of a branching epithelium 0.0002174 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 0.0002528 Highly Informative Direct
Biological Process (BP) adult behavior 0.0008294 Highly Informative Direct
Biological Process (BP) kidney development 0.9777 Highly Informative Inherited
Biological Process (BP) epithelial cell development 0.4221 Highly Informative Inherited
Biological Process (BP) organelle assembly 0.6283 Highly Informative Inherited
Biological Process (BP) sensory perception 0.001619 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.00338 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.01809 Highly Informative Inherited
Biological Process (BP) positive regulation of protein transport 0.08762 Highly Informative Inherited
Biological Process (BP) regulation of nucleocytoplasmic transport 0.516 Highly Informative Inherited
Biological Process (BP) regulation of intracellular protein transport 0.01075 Highly Informative Inherited
Biological Process (BP) regulation of protein localization to nucleus 0.04014 Highly Informative Inherited
Biological Process (BP) regulation of protein catabolic process 0.1148 Highly Informative Inherited
Biological Process (BP) organelle localization 0.004432 Highly Informative Inherited
Biological Process (BP) regulation of multicellular organism growth 0.002853 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.02828 Highly Informative Inherited
Biological Process (BP) epithelial tube morphogenesis 0.08462 Highly Informative Inherited
Biological Process (BP) regulation of protein complex assembly 0.4528 Highly Informative Inherited
Biological Process (BP) cell fate commitment 0.2532 Highly Informative Inherited
Biological Process (BP) regulation of cell projection organization 0.04848 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis 0.001471 Highly Informative Inherited
Biological Process (BP) cell projection assembly 0.014 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane transport 0.01161 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.6804 Highly Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 1 Highly Informative Inherited
Biological Process (BP) protein localization to nucleus 0.5441 Highly Informative Inherited
Biological Process (BP) nuclear import 0.1176 Highly Informative Inherited
Biological Process (BP) protein import 0.2868 Highly Informative Inherited
Biological Process (BP) protein targeting to nucleus 0.4693 Highly Informative Inherited
Biological Process (BP) negative regulation of cell cycle 0.01196 Highly Informative Inherited
Biological Process (BP) regulation of blood pressure 0.06403 Highly Informative Inherited
Biological Process (BP) gastrulation 0.001798 Highly Informative Inherited
Biological Process (BP) microtubule cytoskeleton organization 0.04394 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) protein binding 0 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 2.682e-05 Moderately Informative Direct
Molecular Function (MF) heterocyclic compound binding 1 Moderately Informative Inherited
Molecular Function (MF) organic cyclic compound binding 1 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity 0.861 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.05326 Moderately Informative Inherited
Molecular Function (MF) structural molecule activity 0.007413 Moderately Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0 Informative Direct
Molecular Function (MF) cofactor binding 0.00166 Informative Inherited
Molecular Function (MF) nucleotide binding 0.2461 Informative Inherited
Molecular Function (MF) receptor binding 0.908 Informative Inherited
Molecular Function (MF) GTPase regulator activity 0.4172 Informative Inherited
Molecular Function (MF) enzyme binding 0.2294 Informative Inherited
Molecular Function (MF) monooxygenase activity 1.654e-10 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 1.074e-07 Highly Informative Direct
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0.0002222 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0.276 Highly Informative Inherited
Molecular Function (MF) small GTPase regulator activity 0.6774 Highly Informative Inherited
Molecular Function (MF) glycosaminoglycan binding 0.001517 Highly Informative Inherited
Molecular Function (MF) sulfur compound binding 0.07406 Highly Informative Inherited
Molecular Function (MF) tubulin binding 0.1746 Highly Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 3.213e-07 Least Informative Direct
Cellular Component (CC) protein complex 3.477e-05 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.7683 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) membrane 0.3444 Least Informative Inherited
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0 Moderately Informative Direct
Cellular Component (CC) endomembrane system 0.07921 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 0.09484 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 1 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 1 Moderately Informative Inherited
Cellular Component (CC) extracellular region 1 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 0.009088 Moderately Informative Inherited
Cellular Component (CC) contractile fiber part 0 Informative Direct
Cellular Component (CC) cell cortex 0 Informative Direct
Cellular Component (CC) cell projection part 9.002e-14 Informative Direct
Cellular Component (CC) nuclear envelope 7.342e-11 Informative Direct
Cellular Component (CC) actin cytoskeleton 0 Informative Direct
Cellular Component (CC) cell leading edge 0 Informative Direct
Cellular Component (CC) cell junction 0 Informative Direct
Cellular Component (CC) neuron part 1.092e-11 Informative Direct
Cellular Component (CC) synapse 0.06482 Informative Inherited
Cellular Component (CC) integral to membrane 1 Informative Inherited
Cellular Component (CC) intrinsic to plasma membrane 1 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) extracellular matrix 0.1989 Informative Inherited
Cellular Component (CC) cortical cytoskeleton 1.442e-10 Highly Informative Direct
Cellular Component (CC) cytoplasmic microtubule 0 Highly Informative Direct
Cellular Component (CC) adherens junction 0 Highly Informative Direct
Cellular Component (CC) actin filament 3.199e-14 Highly Informative Direct
Cellular Component (CC) spindle 1.524e-13 Highly Informative Direct
Cellular Component (CC) growth cone 9.107e-09 Highly Informative Direct
Cellular Component (CC) cell-substrate junction 3.135e-07 Highly Informative Direct
Cellular Component (CC) apical plasma membrane 3.594e-06 Highly Informative Direct
Cellular Component (CC) cell division site part 2.442e-05 Highly Informative Direct
Cellular Component (CC) nuclear membrane 3.463e-05 Highly Informative Direct
Cellular Component (CC) neuromuscular junction 0.0001268 Highly Informative Direct
Cellular Component (CC) midbody 0.0002767 Highly Informative Direct
Cellular Component (CC) axon part 0.4461 Highly Informative Inherited
Cellular Component (CC) cell body 0.08493 Highly Informative Inherited
Cellular Component (CC) cell-cell junction 1 Highly Informative Inherited
Cellular Component (CC) basolateral plasma membrane 0.02957 Highly Informative Inherited
Cellular Component (CC) receptor complex 0.7996 Highly Informative Inherited
Cellular Component (CC) integral to plasma membrane 1 Highly Informative Inherited
Cellular Component (CC) intermediate filament cytoskeleton 0.1904 Highly Informative Inherited
Cellular Component (CC) proteinaceous extracellular matrix 0.01526 Highly Informative Inherited

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.805Least InformativeInherited
Disease Ontology (DO)neuromuscular disease0.03691InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.2572Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle physiology0.3179Moderately InformativeInherited
Phenotypic Abnormality (PA)Proximal muscle weakness8.188e-05InformativeDirect
Phenotypic Abnormality (PA)Abnormality of circulating enzyme level0.0003008InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.8465Least InformativeInherited
Mammalian Phenotype (MP)abnormal cell migration0.02589InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.001041Least InformativeInherited
Worm Phenotype (WP)locomotion variant0.0003113Moderately InformativeDirect
Worm Phenotype (WP)early embryonic lethal0.005971Moderately InformativeInherited
Worm Phenotype (WP)organ system development variant0.006891Moderately InformativeInherited
Worm Phenotype (WP)brood size variant9.212e-07InformativeDirect
Worm Phenotype (WP)body wall muscle morphology variant1.303e-06InformativeDirect
Worm Phenotype (WP)exploded through vulva0.0002208InformativeDirect
Worm Phenotype (WP)cell division variant0.1266InformativeInherited
Worm Phenotype (WP)body wall muscle myosin organization defective3.592e-05Highly InformativeDirect
Worm Phenotype (WP)cleavage furrow defective early emb4.908e-05Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)cell0.0425Least InformativeInherited
Fly Anatomy (FA)organ system0.3869Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)adult segment0.1057Moderately InformativeInherited
Fly Anatomy (FA)adult thorax0.2705Moderately InformativeInherited
Fly Anatomy (FA)thoracic segment0.8149Moderately InformativeInherited
Fly Anatomy (FA)muscle system0.005242InformativeInherited
Fly Anatomy (FA)syncytium0.009052InformativeInherited
Fly Anatomy (FA)muscle cell0.01747InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)trunk0Moderately InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)portion of tissue0.2228Least InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.0001184Moderately InformativeDirect
Xenopus ANatomical entity (XAN)skeletal system0.0007014InformativeDirect
Xenopus ANatomical entity (XAN)bone tissue0.0001539Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCell cycle0Moderately InformativeDirect
Biological processMitosis0InformativeDirect
Biological processAngiogenesis2.27e-09InformativeDirect
Biological processCell adhesion3.698e-07InformativeDirect
Biological processWnt signaling pathway4.958e-07InformativeDirect
Biological processExocytosis6.369e-08Highly InformativeDirect
Biological processCilium biogenesis/degradation6.369e-08Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentMembrane0.8705Least InformativeInherited
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentMicrotubule0InformativeDirect
Cellular componentPostsynaptic cell membrane2.471e-06InformativeDirect
DomainRepeat0Least InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
DomainSH3 domain3.779e-15InformativeDirect
DomainSH2 domain1.777e-08InformativeDirect
DomainLeucine-rich repeat0.0002555InformativeDirect
Molecular functionZinc1.497e-05Least InformativeDirect
Molecular functionMetal-binding0.0003091Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionActin-binding0InformativeDirect
Molecular functionCalmodulin-binding0InformativeDirect
Molecular functionFAD6.846e-07InformativeDirect
Molecular functionFlavoprotein2.735e-05InformativeDirect
Molecular functionLIM domain0Highly InformativeDirect
Post-translational modificationOxidoreductase1Moderately InformativeInherited
Post-translational modificationGuanine-nucleotide releasing factor0InformativeDirect
Post-translational modificationActin capping0Highly InformativeDirect
Post-translational modificationMuscle protein5.207e-12Highly InformativeDirect
Post-translational modificationMonooxygenase3.463e-11Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationAcetylation2.292e-06Moderately InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 17 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Calponin-homology domain, CH-domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 17 hidden Markov models representing the Calponin-homology domain, CH-domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


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