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Calponin-homology domain, CH-domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   CH domain-like [ 47575] (3)
Superfamily:   Calponin-homology domain, CH-domain [ 47576]
Families:   Calponin-homology domain, CH-domain [ 47577] (9)


Superfamily statistics
Genomes (502) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 12,544 13,257 21
Proteins 12,293 13,060 21


Functional annotation
General category General
Detailed category General

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism cellular process0.26010Least InformativeInherited
Biological Process (BP)system development0.46760.448Moderately InformativeInherited
Biological Process (BP)cell adhesion0.00011010.0000001183InformativeDirect
Biological Process (BP)actin filament-based process0.00044670InformativeDirect
Biological Process (BP)muscle structure development0.000033040Highly InformativeDirect
Molecular Function (MF)binding0.0074840Least InformativeInherited
Molecular Function (MF)protein binding0.00010340Moderately InformativeDirect
Molecular Function (MF)cytoskeletal protein binding0.000000000012860InformativeDirect
Cellular Component (CC)non-membrane-bounded organelle0.0000000013120Least InformativeDirect
Cellular Component (CC)intracellular organelle part0.049930Least InformativeInherited
Cellular Component (CC)cytoplasmic part10.1304Least InformativeInherited
Cellular Component (CC)cell projection0.0004870Moderately InformativeDirect
Cellular Component (CC)cytoskeleton0.001870Moderately InformativeInherited
Cellular Component (CC)cell projection part0.000021950InformativeDirect
Cellular Component (CC)cytoplasmic region0.00010280InformativeDirect
Cellular Component (CC)contractile fiber part0.0000010220Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) biological regulation 0.00000926 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.9318 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular developmental process 0 Moderately Informative Direct
Biological Process (BP) organelle organization 0 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.000563 Moderately Informative Direct
Biological Process (BP) signaling 0.0003777 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.00000002524 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0 Moderately Informative Direct
Biological Process (BP) cellular localization 0.00000001046 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.00000005021 Moderately Informative Direct
Biological Process (BP) cellular component assembly 0.000000301 Moderately Informative Direct
Biological Process (BP) response to external stimulus 0.000002256 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.0003023 Moderately Informative Direct
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) system development 0.448 Moderately Informative Inherited
Biological Process (BP) reproduction 0.002239 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.9621 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.0597 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.3758 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.002107 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.1989 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.05701 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.4097 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.8008 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.8465 Moderately Informative Inherited
Biological Process (BP) oxidation-reduction process 0.004956 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.07073 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to stress 1 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.5829 Moderately Informative Inherited
Biological Process (BP) cell adhesion 0.0000001183 Informative Direct
Biological Process (BP) actin filament-based process 0 Informative Direct
Biological Process (BP) cytoskeleton organization 0 Informative Direct
Biological Process (BP) cellular component morphogenesis 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) cell development 0 Informative Direct
Biological Process (BP) organelle assembly 0 Informative Direct
Biological Process (BP) microtubule-based process 0 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0.00000000000001746 Informative Direct
Biological Process (BP) regulation of growth 0.000000000001156 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.00000000003635 Informative Direct
Biological Process (BP) regulation of organelle organization 0.0000000003408 Informative Direct
Biological Process (BP) behavior 0.00000004438 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.0000003958 Informative Direct
Biological Process (BP) single-organism membrane organization 0.000004403 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0.000005305 Informative Direct
Biological Process (BP) multi-organism reproductive process 0.00001844 Informative Direct
Biological Process (BP) positive regulation of developmental process 0.00001927 Informative Direct
Biological Process (BP) cell cycle process 0.00002415 Informative Direct
Biological Process (BP) generation of neurons 0.00009499 Informative Direct
Biological Process (BP) regulation of cell differentiation 0.0002714 Informative Direct
Biological Process (BP) regulation of nervous system development 0.0004131 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0.000538 Informative Direct
Biological Process (BP) cellular response to hormone stimulus 0.01702 Informative Inherited
Biological Process (BP) circulatory system development 1 Informative Inherited
Biological Process (BP) reproductive system development 1 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.02674 Informative Inherited
Biological Process (BP) protein localization to organelle 0.8777 Informative Inherited
Biological Process (BP) regulation of protein localization 0.7945 Informative Inherited
Biological Process (BP) regulation of cellular localization 0.166 Informative Inherited
Biological Process (BP) regulation of catabolic process 0.1025 Informative Inherited
Biological Process (BP) regulation of protein modification process 0.06404 Informative Inherited
Biological Process (BP) regulation of phosphorylation 0.1248 Informative Inherited
Biological Process (BP) positive regulation of transport 0.7032 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.001818 Informative Inherited
Biological Process (BP) regulation of transmembrane transport 0.1006 Informative Inherited
Biological Process (BP) central nervous system development 0.3973 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.01348 Informative Inherited
Biological Process (BP) positive regulation of gene expression 1 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 1 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) regulation of transcription, DNA-templated 1 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 1 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.4138 Informative Inherited
Biological Process (BP) regulation of system process 0.02578 Informative Inherited
Biological Process (BP) embryo development 1 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.6333 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) single organism reproductive process 0.5228 Informative Inherited
Biological Process (BP) post-embryonic development 0.009767 Informative Inherited
Biological Process (BP) multicellular organism reproduction 1 Informative Inherited
Biological Process (BP) DNA metabolic process 1 Informative Inherited
Biological Process (BP) system process 1 Informative Inherited
Biological Process (BP) regulation of ion transport 0.03864 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.8056 Informative Inherited
Biological Process (BP) muscle structure development 0 Highly Informative Direct
Biological Process (BP) actin filament organization 0 Highly Informative Direct
Biological Process (BP) negative regulation of cytoskeleton organization 0 Highly Informative Direct
Biological Process (BP) regulation of protein complex disassembly 0 Highly Informative Direct
Biological Process (BP) chemotaxis 0 Highly Informative Direct
Biological Process (BP) cellular component assembly involved in morphogenesis 0 Highly Informative Direct
Biological Process (BP) positive regulation of growth 0 Highly Informative Direct
Biological Process (BP) cell projection organization 0.000000000000003692 Highly Informative Direct
Biological Process (BP) instar larval or pupal morphogenesis 0.0000000000001678 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 0.00000000001393 Highly Informative Direct
Biological Process (BP) positive regulation of cell development 0.0000000000652 Highly Informative Direct
Biological Process (BP) locomotory behavior 0.000000003428 Highly Informative Direct
Biological Process (BP) endosomal transport 0.00000007 Highly Informative Direct
Biological Process (BP) positive regulation of nervous system development 0.00000007898 Highly Informative Direct
Biological Process (BP) positive regulation of cellular component biogenesis 0.0000002135 Highly Informative Direct
Biological Process (BP) female gamete generation 0.0000009005 Highly Informative Direct
Biological Process (BP) establishment of protein localization to membrane 0.0000009642 Highly Informative Direct
Biological Process (BP) establishment of organelle localization 0.00000247 Highly Informative Direct
Biological Process (BP) cellular component disassembly 0.000003055 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.000003865 Highly Informative Direct
Biological Process (BP) actomyosin structure organization 0.00001051 Highly Informative Direct
Biological Process (BP) maintenance of location in cell 0.00001283 Highly Informative Direct
Biological Process (BP) cell division 0.00006611 Highly Informative Direct
Biological Process (BP) DNA methylation or demethylation 0.00007046 Highly Informative Direct
Biological Process (BP) vesicle-mediated transport to the plasma membrane 0.00008634 Highly Informative Direct
Biological Process (BP) negative regulation of homeostatic process 0.0000953 Highly Informative Direct
Biological Process (BP) negative regulation of protein polymerization 0.0001038 Highly Informative Direct
Biological Process (BP) negative regulation of catabolic process 0.0001332 Highly Informative Direct
Biological Process (BP) regulation of cell growth 0.0001856 Highly Informative Direct
Biological Process (BP) wound healing 0.0003862 Highly Informative Direct
Biological Process (BP) metamorphosis 0.0005345 Highly Informative Direct
Biological Process (BP) positive regulation of transporter activity 0.0007506 Highly Informative Direct
Biological Process (BP) regulation of transmembrane transporter activity 0.0008847 Highly Informative Direct
Biological Process (BP) epithelial cell differentiation 0.5334 Highly Informative Inherited
Biological Process (BP) regulation of cell size 0.02378 Highly Informative Inherited
Biological Process (BP) pattern specification process 1 Highly Informative Inherited
Biological Process (BP) tube morphogenesis 0.05996 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.0103 Highly Informative Inherited
Biological Process (BP) neuron development 1 Highly Informative Inherited
Biological Process (BP) appendage development 0.2224 Highly Informative Inherited
Biological Process (BP) anatomical structure homeostasis 0.005009 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.2293 Highly Informative Inherited
Biological Process (BP) cell maturation 0.9604 Highly Informative Inherited
Biological Process (BP) cell junction assembly 0.002368 Highly Informative Inherited
Biological Process (BP) regulation of protein import into nucleus 0.08107 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular protein localization 0.002845 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.0298 Highly Informative Inherited
Biological Process (BP) regulation of protein catabolic process 0.1134 Highly Informative Inherited
Biological Process (BP) response to nutrient levels 0.006463 Highly Informative Inherited
Biological Process (BP) hemostasis 0.00104 Highly Informative Inherited
Biological Process (BP) coagulation 0.1619 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 1 Highly Informative Inherited
Biological Process (BP) brain development 0.6249 Highly Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 1 Highly Informative Inherited
Biological Process (BP) positive regulation of transcription, DNA-templated 1 Highly Informative Inherited
Biological Process (BP) cellular response to external stimulus 0.07198 Highly Informative Inherited
Biological Process (BP) germ cell development 1 Highly Informative Inherited
Biological Process (BP) sensory perception 0.003924 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.1975 Highly Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 0.5725 Highly Informative Inherited
Biological Process (BP) endomembrane system organization 0.05909 Highly Informative Inherited
Biological Process (BP) muscle system process 0.01287 Highly Informative Inherited
Biological Process (BP) macromolecule methylation 0.07357 Highly Informative Inherited
Biological Process (BP) regulation of blood pressure 0.005563 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 0.8944 Highly Informative Inherited
Biological Process (BP) microtubule cytoskeleton organization 0.1443 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) protein binding 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.000103 Moderately Informative Direct
Molecular Function (MF) small molecule binding 1 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 1 Moderately Informative Inherited
Molecular Function (MF) structural molecule activity 0.006578 Moderately Informative Inherited
Molecular Function (MF) molecular function regulator 0.009775 Moderately Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0 Informative Direct
Molecular Function (MF) macromolecular complex binding 0.00000000000006362 Informative Direct
Molecular Function (MF) protein dimerization activity 0.000000001805 Informative Direct
Molecular Function (MF) coenzyme binding 0.00000006622 Informative Direct
Molecular Function (MF) identical protein binding 0.00000007716 Informative Direct
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) enzyme binding 0.8932 Informative Inherited
Molecular Function (MF) sulfur compound binding 0.06709 Informative Inherited
Molecular Function (MF) actin filament binding 0.0000001365 Highly Informative Direct
Molecular Function (MF) protein homodimerization activity 0 Highly Informative Direct
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0.000000006646 Highly Informative Direct
Molecular Function (MF) monooxygenase activity 0.000000007137 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 0.0000001603 Highly Informative Direct
Molecular Function (MF) heparin binding 0.0003071 Highly Informative Direct
Molecular Function (MF) tubulin binding 0.7613 Highly Informative Inherited
Molecular Function (MF) transcription factor binding 0.7299 Highly Informative Inherited
Molecular Function (MF) transcription factor activity, transcription factor binding 0.1806 Highly Informative Inherited
Molecular Function (MF) small GTPase binding 0.7693 Highly Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0 Least Informative Direct
Cellular Component (CC) membrane 0.000000000000909 Least Informative Direct
Cellular Component (CC) protein complex 0.000008841 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.1304 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) membrane protein complex 0.1617 Moderately Informative Inherited
Cellular Component (CC) vesicle 0.01917 Moderately Informative Inherited
Cellular Component (CC) whole membrane 1 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 1 Moderately Informative Inherited
Cellular Component (CC) intrinsic component of membrane 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 1 Moderately Informative Inherited
Cellular Component (CC) extracellular region part 0.5506 Moderately Informative Inherited
Cellular Component (CC) cell projection part 0 Informative Direct
Cellular Component (CC) cytoplasmic region 0 Informative Direct
Cellular Component (CC) actin cytoskeleton 0 Informative Direct
Cellular Component (CC) site of polarized growth 0 Informative Direct
Cellular Component (CC) cell junction 0 Informative Direct
Cellular Component (CC) apical part of cell 0.000000001313 Informative Direct
Cellular Component (CC) nuclear envelope 0.0000003488 Informative Direct
Cellular Component (CC) plasma membrane protein complex 0.000006452 Informative Direct
Cellular Component (CC) plasma membrane region 0.00001582 Informative Direct
Cellular Component (CC) synapse 0.0004017 Informative Direct
Cellular Component (CC) cell surface 1 Informative Inherited
Cellular Component (CC) cytoplasmic vesicle part 0.951 Informative Inherited
Cellular Component (CC) endosome 0.3362 Informative Inherited
Cellular Component (CC) neuron projection 1 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) outer membrane 0.0383 Informative Inherited
Cellular Component (CC) contractile fiber part 0 Highly Informative Direct
Cellular Component (CC) cell-substrate junction 0 Highly Informative Direct
Cellular Component (CC) growth cone 0 Highly Informative Direct
Cellular Component (CC) lateral plasma membrane 0 Highly Informative Direct
Cellular Component (CC) lamellipodium 0 Highly Informative Direct
Cellular Component (CC) cortical cytoskeleton 0 Highly Informative Direct
Cellular Component (CC) anchoring junction 0 Highly Informative Direct
Cellular Component (CC) polymeric cytoskeletal fiber 0.00000000000000601 Highly Informative Direct
Cellular Component (CC) nuclear membrane 0.0000001111 Highly Informative Direct
Cellular Component (CC) spindle 0.00001592 Highly Informative Direct
Cellular Component (CC) apical plasma membrane 0.00001752 Highly Informative Direct
Cellular Component (CC) receptor complex 0.0003357 Highly Informative Direct
Cellular Component (CC) extracellular matrix 0.000385 Highly Informative Direct
Cellular Component (CC) cell division site 0.0004897 Highly Informative Direct
Cellular Component (CC) endosome membrane 0.1499 Highly Informative Inherited
Cellular Component (CC) neuronal cell body 1 Highly Informative Inherited
Cellular Component (CC) basolateral plasma membrane 0.04276 Highly Informative Inherited
Cellular Component (CC) intrinsic component of plasma membrane 1 Highly Informative Inherited
Cellular Component (CC) cell-cell junction 1 Highly Informative Inherited

Document: GO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the musculature0.01734Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.09141Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.2363Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the face0.332Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of long bone morphology0.1387Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle physiology0.2862Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle morphology0.3921Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digit0.4654Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the hand0.9946Moderately InformativeInherited
Phenotypic Abnormality (PA)Proximal muscle weakness0.0005139InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the musculature of the upper limbs0.01971InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the thorax0.02213InformativeInherited
Phenotypic Abnormality (PA)Abnormal facial shape0.1807InformativeInherited
Phenotypic Abnormality (PA)Abnormality of phalanx of finger0.1883InformativeInherited
Phenotypic Abnormality (PA)Abnormality of upper limb bone0.2889InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle size0.3074InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the calf musculature0.00001132Highly InformativeDirect
Phenotypic Abnormality (PA)Broad thumb0.0001455Highly InformativeDirect
Phenotypic Abnormality (PA)Flat face0.0005485Highly InformativeDirect
Phenotypic Abnormality (PA)Scapular winging0.0008015Highly InformativeDirect
Phenotypic Abnormality (PA)Distal amyotrophy0.1334Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.1377Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.4315Least InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.02969Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.1236Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.3959Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.4836Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.6448Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.8703Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mature B cell morphology0.1183InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation0.3144InformativeInherited
Mammalian Phenotype (MP)abnormal intestine morphology0.3555InformativeInherited
Mammalian Phenotype (MP)increased hematopoietic cell number0.6048InformativeInherited
Mammalian Phenotype (MP)abnormal exercise endurance0.000131Highly InformativeDirect
Mammalian Phenotype (MP)abnormal transitional stage T1 B cell morphology0.0001556Highly InformativeDirect
Mammalian Phenotype (MP)abnormal transitional stage T2 B cell morphology0.000216Highly InformativeDirect
Mammalian Phenotype (MP)intestinal ulcer0.0009169Highly InformativeDirect
Mammalian Phenotype (MP)decreased immature B cell number0.1521Highly InformativeInherited
Mammalian Phenotype (MP)increased B cell number0.2457Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell morphology variant0.000005519Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.0005257Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.001367Least InformativeInherited
Worm Phenotype (WP)cell development variant0.04787Least InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.001828Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.2692Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.291Moderately InformativeInherited
Worm Phenotype (WP)brood size variant0.0000004816InformativeDirect
Worm Phenotype (WP)muscle system morphology variant0.000002277InformativeDirect
Worm Phenotype (WP)cytokinesis variant emb0.00001633InformativeDirect
Worm Phenotype (WP)neuronal outgrowth variant0.0003752InformativeDirect
Worm Phenotype (WP)protein metabolism variant0.005163InformativeInherited
Worm Phenotype (WP)epithelial system development variant0.04931InformativeInherited
Worm Phenotype (WP)axon guidance variant0.0001187Highly InformativeDirect
Worm Phenotype (WP)exploded through vulva0.0003392Highly InformativeDirect
Worm Phenotype (WP)cytokinesis defective early emb0.006426Highly InformativeInherited
Worm Phenotype (WP)body wall muscle thick filament variant0.2634Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)cell0.0249Least InformativeInherited
Fly Anatomy (FA)muscle system0.002034InformativeInherited
Fly Anatomy (FA)syncytium0.004259InformativeInherited
Fly Anatomy (FA)muscle cell0.00938InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)anatomical cluster0.597Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.8533Least InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.004998Moderately InformativeInherited
Xenopus ANatomical entity (XAN)connective tissue0.0007238InformativeDirect
Xenopus ANatomical entity (XAN)skeletal system0.00501InformativeInherited
Xenopus ANatomical entity (XAN)solid compound organ0.06702InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCell cycle0Moderately InformativeDirect
Biological processMitosis0InformativeDirect
Biological processAngiogenesis0.000000008805InformativeDirect
Biological processCell adhesion0.0000004557InformativeDirect
Biological processWnt signaling pathway0.0000009304InformativeDirect
Biological processEndocytosis0.00003136InformativeDirect
Biological processExocytosis0.0000001573Highly InformativeDirect
Biological processCilium biogenesis/degradation0.0000008279Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentNucleus0.00001276Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentEndosome0.0002348Moderately InformativeDirect
Cellular componentMicrotubule0InformativeDirect
Cellular componentSynapse1InformativeInherited
Cellular componentPostsynaptic cell membrane0.00000348Highly InformativeDirect
Coding sequence diversityAlternative splicing0.000433Least InformativeDirect
DomainRepeat0Least InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
DomainSH3 domain0.000000000000005184InformativeDirect
DomainSH2 domain0.00000002013InformativeDirect
DomainLeucine-rich repeat0.0004017InformativeDirect
DomainLIM domain0Highly InformativeDirect
Molecular functionZinc0.00000423Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionActin-binding0InformativeDirect
Molecular functionCalmodulin-binding0InformativeDirect
Molecular functionFAD0.000001554InformativeDirect
Post-translational modificationOxidoreductase1Moderately InformativeInherited
Post-translational modificationGuanine-nucleotide releasing factor0InformativeDirect
Post-translational modificationActin capping4.502e-16Highly InformativeDirect
Post-translational modificationMuscle protein0.000000000009615Highly InformativeDirect
Post-translational modificationMonooxygenase0.00000000003816Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationAcetylation0.000000000004047Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 17 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Calponin-homology domain, CH-domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 17 hidden Markov models representing the Calponin-homology domain, CH-domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]