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Calponin-homology domain, CH-domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   CH domain-like [ 47575] (3)
Superfamily:   Calponin-homology domain, CH-domain [ 47576]
Families:   Calponin-homology domain, CH-domain [ 47577] (9)


Superfamily statistics
Genomes (509) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 12,940 39,216 21
Proteins 12,673 38,606 21


Functional annotation
General category General
Detailed category General

Document:
Function annotation of SCOP domain superfamilies

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.1336Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature0.2159Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.2446Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the skeletal system0.6269Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiovascular system physiology0.0143Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.04002Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.06315Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper limb0.1091Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal muscle morphology0.1815Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.3306Moderately InformativeInherited
Phenotypic Abnormality (PA)Lipodystrophy0.0001738InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the thorax0.1022InformativeInherited
Phenotypic Abnormality (PA)Abnormality of joint mobility0.1623InformativeInherited
Phenotypic Abnormality (PA)Decreased cervical spine flexion due to contractures of posterior cervical muscles0.00001617Highly InformativeDirect
Phenotypic Abnormality (PA)Heart block0.0005543Highly InformativeDirect
Phenotypic Abnormality (PA)Contractures involving the joints of the feet0.0008828Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the Achilles tendon0.0009947Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.1191Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.5374Least InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.02416Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.11Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.3975Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.4623Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.702Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.7829Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mature B cell morphology0.1094InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation0.3181InformativeInherited
Mammalian Phenotype (MP)abnormal intestine morphology0.3478InformativeInherited
Mammalian Phenotype (MP)increased leukocyte cell number0.6739InformativeInherited
Mammalian Phenotype (MP)abnormal exercise endurance0.0001408Highly InformativeDirect
Mammalian Phenotype (MP)abnormal transitional stage T1 B cell morphology0.0001607Highly InformativeDirect
Mammalian Phenotype (MP)abnormal transitional stage T2 B cell morphology0.0002201Highly InformativeDirect
Mammalian Phenotype (MP)intestinal ulcer0.0008029Highly InformativeDirect
Mammalian Phenotype (MP)decreased immature B cell number0.1488Highly InformativeInherited
Mammalian Phenotype (MP)increased B cell number0.2538Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell morphology variant0.00000004203Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.00005067Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.0006582Least InformativeDirect
Worm Phenotype (WP)cell development variant0.05177Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.3261Least InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.001666Moderately InformativeInherited
Worm Phenotype (WP)metabolic pathway variant0.005127Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.4583Moderately InformativeInherited
Worm Phenotype (WP)cell component morphology variant0.5125Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.5567Moderately InformativeInherited
Worm Phenotype (WP)brood size variant0.0000007035InformativeDirect
Worm Phenotype (WP)protein degradation variant0.00005722InformativeDirect
Worm Phenotype (WP)muscle cell physiology variant0.00008677InformativeDirect
Worm Phenotype (WP)cytokinesis variant emb0.000155InformativeDirect
Worm Phenotype (WP)axon outgrowth variant0.00103InformativeInherited
Worm Phenotype (WP)epithelial system development variant0.05137InformativeInherited
Worm Phenotype (WP)organelle organization biogenesis variant0.1974InformativeInherited
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.6973InformativeInherited
Worm Phenotype (WP)cleavage furrow defective0.000003418Highly InformativeDirect
Worm Phenotype (WP)axon guidance variant0.0001619Highly InformativeDirect
Worm Phenotype (WP)exploded through vulva0.0003221Highly InformativeDirect
Worm Phenotype (WP)cytoskeleton organization biogenesis variant0.0003554Highly InformativeDirect
Worm Phenotype (WP)cytokinesis defective early emb0.008026Highly InformativeInherited
Worm Phenotype (WP)body wall muscle thick filament variant0.1862Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)somatic cell0.06502Least InformativeInherited
Fly Anatomy (FA)adult0.06667Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)adult segment0.1687Moderately InformativeInherited
Fly Anatomy (FA)thorax0.6929Moderately InformativeInherited
Fly Anatomy (FA)muscle system0.002358InformativeInherited
Fly Anatomy (FA)syncytium0.002921InformativeInherited
Fly Anatomy (FA)flight muscle0.0003251Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0.000000000000005945Least InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation of one atom of oxygen0Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 46 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Calponin-homology domain, CH-domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 46 hidden Markov models representing the Calponin-homology domain, CH-domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]