SUPERFAMILY 1.75 HMM library and genome assignments server

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Calponin-homology domain, CH-domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   CH domain-like [ 47575] (3)
Superfamily:   Calponin-homology domain, CH-domain [ 47576]
Families:   Calponin-homology domain, CH-domain [ 47577] (9)


Superfamily statistics
Genomes (509) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 12,940 39,216 21
Proteins 12,673 38,606 21


Functional annotation
General category General
Detailed category General

Document:
Function annotation of SCOP domain superfamilies

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.08538Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.1003Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.1357Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature0.179Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.403Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.01961Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system physiology0.03565Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the thorax0.08856Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper limb0.1241Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of circulating protein level0.003996InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system electrophysiology0.04018InformativeInherited
Phenotypic Abnormality (PA)Functional motor deficit0.1571InformativeInherited
Phenotypic Abnormality (PA)Muscle weakness0.3636InformativeInherited
Phenotypic Abnormality (PA)Lipodystrophy0.00005957Highly InformativeDirect
Phenotypic Abnormality (PA)Pectus excavatum0.0003277Highly InformativeDirect
Phenotypic Abnormality (PA)Atrioventricular block0.0005879Highly InformativeDirect
Phenotypic Abnormality (PA)Elevated serum creatine phosphokinase0.0007507Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.1193Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.5385Least InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.02423Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.1101Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.3981Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.4629Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.702Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.7829Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mature B cell morphology0.1096InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation0.3179InformativeInherited
Mammalian Phenotype (MP)abnormal intestine morphology0.3477InformativeInherited
Mammalian Phenotype (MP)increased leukocyte cell number0.6736InformativeInherited
Mammalian Phenotype (MP)abnormal exercise endurance0.0001405Highly InformativeDirect
Mammalian Phenotype (MP)abnormal transitional stage T1 B cell morphology0.0001608Highly InformativeDirect
Mammalian Phenotype (MP)abnormal transitional stage T2 B cell morphology0.0002202Highly InformativeDirect
Mammalian Phenotype (MP)intestinal ulcer0.0008036Highly InformativeDirect
Mammalian Phenotype (MP)decreased immature B cell number0.1487Highly InformativeInherited
Mammalian Phenotype (MP)increased B cell number0.2536Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell morphology variant0.0000003158Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.00005177Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.0006582Least InformativeDirect
Worm Phenotype (WP)cell development variant0.05509Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.1964Least InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.001881Moderately InformativeInherited
Worm Phenotype (WP)metabolic pathway variant0.00682Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.4675Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.5378Moderately InformativeInherited
Worm Phenotype (WP)brood size variant0.0000006838InformativeDirect
Worm Phenotype (WP)protein degradation variant0.00005177InformativeDirect
Worm Phenotype (WP)muscle cell physiology variant0.00008699InformativeDirect
Worm Phenotype (WP)cytokinesis variant emb0.000153InformativeDirect
Worm Phenotype (WP)axon outgrowth variant0.0008659InformativeDirect
Worm Phenotype (WP)epithelial system development variant0.0511InformativeInherited
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.6884InformativeInherited
Worm Phenotype (WP)cleavage furrow defective0.000003296Highly InformativeDirect
Worm Phenotype (WP)axon guidance variant0.0001486Highly InformativeDirect
Worm Phenotype (WP)exploded through vulva0.0003469Highly InformativeDirect
Worm Phenotype (WP)cytokinesis defective early emb0.006738Highly InformativeInherited
Worm Phenotype (WP)body wall muscle thick filament variant0.2054Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)somatic cell0.06514Least InformativeInherited
Fly Anatomy (FA)adult0.07173Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)adult segment0.1898Moderately InformativeInherited
Fly Anatomy (FA)adult thorax0.4883Moderately InformativeInherited
Fly Anatomy (FA)thoracic segment0.9382Moderately InformativeInherited
Fly Anatomy (FA)muscle system0.00237InformativeInherited
Fly Anatomy (FA)syncytium0.002791InformativeInherited
Fly Anatomy (FA)flight muscle0.0003098Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0.0000000000000136Least InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation of one atom of oxygen0Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 17 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Calponin-homology domain, CH-domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 17 hidden Markov models representing the Calponin-homology domain, CH-domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]