SUPERFAMILY 1.75 HMM library and genome assignments server


Calponin-homology domain, CH-domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   CH domain-like [ 47575] (3)
Superfamily:   Calponin-homology domain, CH-domain [ 47576]
Families:   Calponin-homology domain, CH-domain [ 47577] (9)


Superfamily statistics
Genomes (449) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 11,270 10,185 21
Proteins 11,048 10,032 21


Functional annotation
General category General
Detailed category General

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)localization0.05420Least InformativeInherited
Biological Process (BP)single-organism cellular process0.008040Least InformativeInherited
Biological Process (BP)macromolecule localization0.00094352.235e-05Moderately InformativeDirect
Biological Process (BP)establishment or maintenance of cell polarity0.000121.772e-10Highly InformativeDirect
Molecular Function (MF)binding7.546e-050Least InformativeDirect
Molecular Function (MF)cytoskeletal protein binding8.83e-130InformativeDirect
Cellular Component (CC)intracellular non-membrane-bounded organelle0.00014920Least InformativeDirect
Cellular Component (CC)cytoplasmic part10.6542Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.16163.446e-10Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)cell projection4.021e-050Moderately InformativeDirect
Cellular Component (CC)cytoskeleton0.033480Moderately InformativeInherited
Cellular Component (CC)endomembrane system0.017130.3732Moderately InformativeInherited
Cellular Component (CC)organelle envelope0.085590.5268Moderately InformativeInherited
Cellular Component (CC)nuclear part0.151Moderately InformativeInherited
Cellular Component (CC)contractile fiber part2.113e-080InformativeDirect
Cellular Component (CC)cell cortex6.682e-080InformativeDirect
Cellular Component (CC)nuclear envelope4.385e-051.968e-08InformativeDirect
Cellular Component (CC)cortical cytoskeleton8.739e-055.908e-11Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.09092 Least Informative Inherited
Biological Process (BP) response to stimulus 0.004844 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) macromolecule localization 2.235e-05 Moderately Informative Direct
Biological Process (BP) cellular localization 1.263e-14 Moderately Informative Direct
Biological Process (BP) organelle organization 0 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 9.08e-11 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 8.602e-10 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 2.704e-05 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0.0005577 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.2262 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.4784 Moderately Informative Inherited
Biological Process (BP) immune system process 0.07514 Moderately Informative Inherited
Biological Process (BP) tissue development 0.4258 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.0785 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.03362 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.883 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.062 Moderately Informative Inherited
Biological Process (BP) homeostatic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.07019 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.9123 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.9789 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.3208 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.1935 Moderately Informative Inherited
Biological Process (BP) reproduction 0.01357 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.1117 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.2318 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.5419 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.03331 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.9936 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.001063 Moderately Informative Inherited
Biological Process (BP) cellular component movement 0 Informative Direct
Biological Process (BP) cytoskeleton organization 0 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0 Informative Direct
Biological Process (BP) microtubule-based process 0 Informative Direct
Biological Process (BP) actin filament-based process 0 Informative Direct
Biological Process (BP) regulation of organelle organization 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) cell projection organization 0 Informative Direct
Biological Process (BP) regulation of anatomical structure size 5.98e-13 Informative Direct
Biological Process (BP) muscle structure development 1.273e-11 Informative Direct
Biological Process (BP) regulation of nucleotide catabolic process 1.402e-11 Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 2.481e-11 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 4.769e-10 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 1.894e-09 Informative Direct
Biological Process (BP) vesicle-mediated transport 2.002e-09 Informative Direct
Biological Process (BP) regulation of growth 1.828e-08 Informative Direct
Biological Process (BP) biological adhesion 8.336e-06 Informative Direct
Biological Process (BP) response to wounding 5.626e-05 Informative Direct
Biological Process (BP) generation of neurons 0.0002049 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.0006042 Informative Direct
Biological Process (BP) regulation of nervous system development 0.0007508 Informative Direct
Biological Process (BP) cellular response to endogenous stimulus 0.4053 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.7023 Informative Inherited
Biological Process (BP) protein localization to organelle 0.04406 Informative Inherited
Biological Process (BP) epithelium development 0.2778 Informative Inherited
Biological Process (BP) regulation of system process 0.6086 Informative Inherited
Biological Process (BP) organ morphogenesis 0.6725 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.002839 Informative Inherited
Biological Process (BP) organelle localization 0.3307 Informative Inherited
Biological Process (BP) cell cycle process 0.002701 Informative Inherited
Biological Process (BP) organelle assembly 0.6851 Informative Inherited
Biological Process (BP) protein complex assembly 1 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 0.451 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.03147 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.01429 Informative Inherited
Biological Process (BP) regulation of cell development 0.01116 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.1793 Informative Inherited
Biological Process (BP) positive regulation of transport 0.8247 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.003706 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.8888 Informative Inherited
Biological Process (BP) membrane organization 0.007132 Informative Inherited
Biological Process (BP) sensory organ development 0.1134 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.3426 Informative Inherited
Biological Process (BP) regulation of establishment of protein localization 0.5961 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.2831 Informative Inherited
Biological Process (BP) cell activation 0.0362 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.1524 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.2786 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.04222 Informative Inherited
Biological Process (BP) localization of cell 0.002766 Informative Inherited
Biological Process (BP) response to nutrient levels 0.004479 Informative Inherited
Biological Process (BP) reproductive structure development 1 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.07487 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.4375 Informative Inherited
Biological Process (BP) central nervous system development 0.005372 Informative Inherited
Biological Process (BP) cell-cell signaling 0.01137 Informative Inherited
Biological Process (BP) single-organism behavior 0.2178 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.001668 Informative Inherited
Biological Process (BP) sexual reproduction 0.3954 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 1 Informative Inherited
Biological Process (BP) protein transport 0.006974 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 1 Informative Inherited
Biological Process (BP) phosphorylation 1 Informative Inherited
Biological Process (BP) regulation of ion transport 0.1033 Informative Inherited
Biological Process (BP) blood circulation 0.008456 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.8562 Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 1.772e-10 Highly Informative Direct
Biological Process (BP) negative regulation of protein complex disassembly 0 Highly Informative Direct
Biological Process (BP) negative regulation of cytoskeleton organization 0 Highly Informative Direct
Biological Process (BP) chemotaxis 0 Highly Informative Direct
Biological Process (BP) regulation of protein depolymerization 0 Highly Informative Direct
Biological Process (BP) positive regulation of growth 7.006e-14 Highly Informative Direct
Biological Process (BP) regulation of cell growth 1.7e-12 Highly Informative Direct
Biological Process (BP) regulation of microtubule polymerization or depolymerization 8.696e-11 Highly Informative Direct
Biological Process (BP) actin filament organization 1.524e-10 Highly Informative Direct
Biological Process (BP) cell junction organization 1.791e-10 Highly Informative Direct
Biological Process (BP) muscle organ development 4.961e-10 Highly Informative Direct
Biological Process (BP) cell division 1.446e-08 Highly Informative Direct
Biological Process (BP) cellular component disassembly 4.833e-08 Highly Informative Direct
Biological Process (BP) tube formation 1.247e-07 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 1.814e-07 Highly Informative Direct
Biological Process (BP) wound healing 1.893e-07 Highly Informative Direct
Biological Process (BP) maintenance of location 2.767e-07 Highly Informative Direct
Biological Process (BP) positive regulation of cell differentiation 3.178e-06 Highly Informative Direct
Biological Process (BP) regulation of sodium ion transport 4.227e-06 Highly Informative Direct
Biological Process (BP) plasma membrane organization 1.816e-05 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 9.177e-05 Highly Informative Direct
Biological Process (BP) morphogenesis of a branching epithelium 0.0001215 Highly Informative Direct
Biological Process (BP) leukocyte migration 0.0001311 Highly Informative Direct
Biological Process (BP) locomotory behavior 0.0002144 Highly Informative Direct
Biological Process (BP) positive regulation of GTPase activity 0.0002908 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 0.0003276 Highly Informative Direct
Biological Process (BP) regulation of myeloid cell differentiation 0.0004391 Highly Informative Direct
Biological Process (BP) post-embryonic organ development 0.0005501 Highly Informative Direct
Biological Process (BP) sensory perception 0.0007132 Highly Informative Direct
Biological Process (BP) female gamete generation 0.0007508 Highly Informative Direct
Biological Process (BP) fruiting body development 0.0008846 Highly Informative Direct
Biological Process (BP) renal system development 1 Highly Informative Inherited
Biological Process (BP) epithelial cell development 0.8295 Highly Informative Inherited
Biological Process (BP) regulation of cell size 0.003767 Highly Informative Inherited
Biological Process (BP) regulation of protein stability 0.1007 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.001146 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.01347 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.02121 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0.3191 Highly Informative Inherited
Biological Process (BP) developmental maturation 1 Highly Informative Inherited
Biological Process (BP) positive regulation of protein transport 0.1066 Highly Informative Inherited
Biological Process (BP) regulation of nucleocytoplasmic transport 0.3231 Highly Informative Inherited
Biological Process (BP) regulation of intracellular protein transport 0.008585 Highly Informative Inherited
Biological Process (BP) regulation of protein localization to nucleus 0.03264 Highly Informative Inherited
Biological Process (BP) regulation of protein catabolic process 0.1908 Highly Informative Inherited
Biological Process (BP) regulation of multicellular organism growth 0.001314 Highly Informative Inherited
Biological Process (BP) epithelial tube morphogenesis 0.06502 Highly Informative Inherited
Biological Process (BP) regulation of Rho protein signal transduction 0.00192 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane transport 0.02541 Highly Informative Inherited
Biological Process (BP) regulation of Ras GTPase activity 0.05981 Highly Informative Inherited
Biological Process (BP) regulation of protein complex assembly 0.409 Highly Informative Inherited
Biological Process (BP) cell adhesion 0.01721 Highly Informative Inherited
Biological Process (BP) cell fate commitment 0.3441 Highly Informative Inherited
Biological Process (BP) cell projection assembly 0.0346 Highly Informative Inherited
Biological Process (BP) regulation of transporter activity 0.007327 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.6107 Highly Informative Inherited
Biological Process (BP) neuron projection development 0.03287 Highly Informative Inherited
Biological Process (BP) cell part morphogenesis 0.1272 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.002911 Highly Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 0.0671 Highly Informative Inherited
Biological Process (BP) protein localization to nucleus 0.7614 Highly Informative Inherited
Biological Process (BP) nuclear import 0.1116 Highly Informative Inherited
Biological Process (BP) protein import 0.2794 Highly Informative Inherited
Biological Process (BP) protein targeting to nucleus 0.7118 Highly Informative Inherited
Biological Process (BP) protein phosphorylation 0.9156 Highly Informative Inherited
Biological Process (BP) regulation of blood pressure 0.05179 Highly Informative Inherited
Biological Process (BP) microtubule cytoskeleton organization 0.09791 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) enzyme regulator activity 2.052e-05 Moderately Informative Direct
Molecular Function (MF) anion binding 5.705e-05 Moderately Informative Direct
Molecular Function (MF) oxidoreductase activity 0.7574 Moderately Informative Inherited
Molecular Function (MF) structural molecule activity 0.002677 Moderately Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0 Informative Direct
Molecular Function (MF) cofactor binding 0.001117 Informative Inherited
Molecular Function (MF) nucleotide binding 0.2217 Informative Inherited
Molecular Function (MF) receptor binding 0.9138 Informative Inherited
Molecular Function (MF) GTPase regulator activity 0.3872 Informative Inherited
Molecular Function (MF) enzyme binding 0.07841 Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 0.2109 Informative Inherited
Molecular Function (MF) Ras GTPase binding 0 Highly Informative Direct
Molecular Function (MF) monooxygenase activity 2.376e-11 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 2.617e-08 Highly Informative Direct
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0.0001179 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0.3446 Highly Informative Inherited
Molecular Function (MF) small GTPase regulator activity 0.7069 Highly Informative Inherited
Molecular Function (MF) tubulin binding 0.09018 Highly Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 3.446e-10 Least Informative Direct
Cellular Component (CC) protein complex 7.514e-05 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.6542 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) membrane 0.003598 Least Informative Inherited
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane part 4.836e-06 Moderately Informative Direct
Cellular Component (CC) organelle membrane 1 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 0.3732 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 0.5268 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) extracellular region part 0.5063 Moderately Informative Inherited
Cellular Component (CC) contractile fiber part 0 Informative Direct
Cellular Component (CC) cell cortex 0 Informative Direct
Cellular Component (CC) nuclear envelope 1.968e-08 Informative Direct
Cellular Component (CC) actin cytoskeleton 0 Informative Direct
Cellular Component (CC) cell leading edge 0 Informative Direct
Cellular Component (CC) endosome 0.6439 Informative Inherited
Cellular Component (CC) neuron projection 0.6126 Informative Inherited
Cellular Component (CC) cell-cell junction 1 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) extracellular matrix 0.1258 Informative Inherited
Cellular Component (CC) cortical cytoskeleton 5.908e-11 Highly Informative Direct
Cellular Component (CC) cytoplasmic microtubule 0 Highly Informative Direct
Cellular Component (CC) adherens junction 0 Highly Informative Direct
Cellular Component (CC) actin filament 0 Highly Informative Direct
Cellular Component (CC) spindle 2.335e-12 Highly Informative Direct
Cellular Component (CC) lateral plasma membrane 3.447e-09 Highly Informative Direct
Cellular Component (CC) growth cone 1.12e-07 Highly Informative Direct
Cellular Component (CC) axon part 1.568e-07 Highly Informative Direct
Cellular Component (CC) cell-substrate junction 3.582e-07 Highly Informative Direct
Cellular Component (CC) apical plasma membrane 6.975e-07 Highly Informative Direct
Cellular Component (CC) recycling endosome 8.265e-07 Highly Informative Direct
Cellular Component (CC) contractile ring 1.077e-06 Highly Informative Direct
Cellular Component (CC) nuclear membrane 1.972e-05 Highly Informative Direct
Cellular Component (CC) cell division site part 3.452e-05 Highly Informative Direct
Cellular Component (CC) neuromuscular junction 7.948e-05 Highly Informative Direct
Cellular Component (CC) intermediate filament 0.0002062 Highly Informative Direct
Cellular Component (CC) midbody 0.0004891 Highly Informative Direct
Cellular Component (CC) endosomal part 0.3428 Highly Informative Inherited
Cellular Component (CC) cell body 0.1815 Highly Informative Inherited
Cellular Component (CC) basolateral plasma membrane 0.03223 Highly Informative Inherited
Cellular Component (CC) proteinaceous extracellular matrix 0.01191 Highly Informative Inherited

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.8333Least InformativeInherited
Disease Ontology (DO)neuromuscular disease0.002374InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.2655Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle physiology0.3133Moderately InformativeInherited
Phenotypic Abnormality (PA)Proximal muscle weakness7.794e-05InformativeDirect
Phenotypic Abnormality (PA)Abnormality of circulating enzyme level0.0003071InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.1186Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.8365Least InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.2115Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.07227InformativeInherited
Mammalian Phenotype (MP)abnormal systemic arterial blood pressure0.08141InformativeInherited
Mammalian Phenotype (MP)abnormal exercise endurance0.0004326Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.001041Least InformativeInherited
Worm Phenotype (WP)locomotion variant0.0003113Moderately InformativeDirect
Worm Phenotype (WP)early embryonic lethal0.005971Moderately InformativeInherited
Worm Phenotype (WP)organ system development variant0.006891Moderately InformativeInherited
Worm Phenotype (WP)brood size variant9.212e-07InformativeDirect
Worm Phenotype (WP)body wall muscle morphology variant1.303e-06InformativeDirect
Worm Phenotype (WP)exploded through vulva0.0002208InformativeDirect
Worm Phenotype (WP)cell division variant0.1266InformativeInherited
Worm Phenotype (WP)body wall muscle myosin organization defective3.592e-05Highly InformativeDirect
Worm Phenotype (WP)cleavage furrow defective early emb4.908e-05Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)cell0.04621Least InformativeInherited
Fly Anatomy (FA)organ system0.4303Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)adult segment0.1029Moderately InformativeInherited
Fly Anatomy (FA)adult thorax0.2547Moderately InformativeInherited
Fly Anatomy (FA)thoracic segment0.798Moderately InformativeInherited
Fly Anatomy (FA)muscle system0.004749InformativeInherited
Fly Anatomy (FA)syncytium0.008412InformativeInherited
Fly Anatomy (FA)muscle cell0.01653InformativeInherited

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)portion of tissue0.2319Least InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.000135Moderately InformativeDirect
Xenopus ANatomical entity (XAN)skeletal system0.0007957InformativeDirect
Xenopus ANatomical entity (XAN)bone tissue0.0001528Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCell cycle0Moderately InformativeDirect
Biological processMitosis0InformativeDirect
Biological processAngiogenesis5.422e-09InformativeDirect
Biological processCell adhesion2.26e-07InformativeDirect
Biological processWnt signaling pathway6.145e-07InformativeDirect
Biological processEndocytosis1.957e-05InformativeDirect
Biological processExocytosis8.431e-08Highly InformativeDirect
Biological processCilium biogenesis/degradation1.35e-07Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentEndosome6.42e-05Moderately InformativeDirect
Cellular componentMicrotubule0InformativeDirect
Cellular componentSynapse1InformativeInherited
Cellular componentPostsynaptic cell membrane1.534e-06Highly InformativeDirect
Coding sequence diversityAlternative promoter usage0.0009961Moderately InformativeDirect
DomainRepeat0Least InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
DomainSH3 domain3.044e-15InformativeDirect
DomainSH2 domain1.504e-08InformativeDirect
DomainLeucine-rich repeat0.0002584InformativeDirect
DomainLIM domain0Highly InformativeDirect
Molecular functionZinc8.102e-07Least InformativeDirect
Molecular functionMetal-binding0.0003518Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionFlavoprotein9.611e-05Moderately InformativeDirect
Molecular functionActin-binding0InformativeDirect
Molecular functionCalmodulin-binding0InformativeDirect
Molecular functionFAD7.14e-07InformativeDirect
Post-translational modificationOxidoreductase1Moderately InformativeInherited
Post-translational modificationGuanine-nucleotide releasing factor0InformativeDirect
Post-translational modificationActin capping0Highly InformativeDirect
Post-translational modificationMuscle protein6.145e-12Highly InformativeDirect
Post-translational modificationMonooxygenase5.705e-11Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationAcetylation5.293e-08Least InformativeDirect

Document: KW annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 17 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Calponin-homology domain, CH-domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 17 hidden Markov models representing the Calponin-homology domain, CH-domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]