SUPERFAMILY 1.75 HMM library and genome assignments server


Calponin-homology domain, CH-domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   CH domain-like [ 47575] (3)
Superfamily:   Calponin-homology domain, CH-domain [ 47576]
Families:   Calponin-homology domain, CH-domain [ 47577] (9)


Superfamily statistics
Genomes (489) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 11,908 0 21
Proteins 11,656 0 21


Functional annotation
General category General
Detailed category General

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)localization0.039050Least InformativeInherited
Biological Process (BP)multicellular organismal process0.018110Least InformativeInherited
Biological Process (BP)developmental process0.017720Least InformativeInherited
Biological Process (BP)single-organism cellular process0.0096460Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.01480Least InformativeInherited
Biological Process (BP)macromolecule localization0.013040.0006819Moderately InformativeInherited
Biological Process (BP)nervous system development0.13980.4442Moderately InformativeInherited
Biological Process (BP)system process0.072731Moderately InformativeInherited
Biological Process (BP)cell differentiation0.013220.1092Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.069670.1758Moderately InformativeInherited
Biological Process (BP)single-organism developmental process0.12481.413e-13Moderately InformativeInherited
Biological Process (BP)muscle system process0.00067630.0004538InformativeDirect
Biological Process (BP)generation of neurons0.0071188.849e-05InformativeInherited
Biological Process (BP)cell projection organization0.011130InformativeInherited
Biological Process (BP)cellular component morphogenesis0.041650.0007916InformativeInherited
Biological Process (BP)establishment or maintenance of cell polarity0.00028682.458e-09Highly InformativeDirect
Biological Process (BP)axon development0.00010640.6718Highly InformativeInherited
Biological Process (BP)cell morphogenesis involved in neuron differentiation0.00011590.1556Highly InformativeInherited
Biological Process (BP)cell projection morphogenesis0.00037220.7319Highly InformativeInherited
Molecular Function (MF)binding5.485e-060Least InformativeDirect
Molecular Function (MF)cytoskeletal protein binding6.754e-160InformativeDirect
Molecular Function (MF)tubulin binding0.84850.1603Highly InformativeInherited
Cellular Component (CC)intracellular non-membrane-bounded organelle3.582e-070Least InformativeDirect
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.14241.077e-09Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)cytoskeleton0.00017670Moderately InformativeDirect
Cellular Component (CC)cell projection0.00061310Moderately InformativeDirect
Cellular Component (CC)endomembrane system0.056760.02826Moderately InformativeInherited
Cellular Component (CC)organelle envelope0.15550.04765Moderately InformativeInherited
Cellular Component (CC)nuclear part0.54011Moderately InformativeInherited
Cellular Component (CC)contractile fiber part3.868e-090InformativeDirect
Cellular Component (CC)cell cortex3.611e-070InformativeDirect
Cellular Component (CC)nuclear envelope0.00019663.132e-15InformativeDirect
Cellular Component (CC)cell-substrate junction2.069e-074.787e-09Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.05548 Least Informative Inherited
Biological Process (BP) response to stimulus 0.00372 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular localization 0 Moderately Informative Direct
Biological Process (BP) organelle organization 0 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.0006819 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 1.413e-13 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 5.551e-09 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 6.849e-05 Moderately Informative Direct
Biological Process (BP) reproduction 0.0004021 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.3404 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.9793 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.4233 Moderately Informative Inherited
Biological Process (BP) tissue development 0.04041 Moderately Informative Inherited
Biological Process (BP) immune system process 0.1135 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.2431 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.001197 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.8828 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.1758 Moderately Informative Inherited
Biological Process (BP) homeostatic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.001457 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.1664 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.7102 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.4806 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.1298 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.1092 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.4442 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.6843 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) oxidation-reduction process 0.004292 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.0211 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.004481 Moderately Informative Inherited
Biological Process (BP) muscle system process 0.0004538 Informative Direct
Biological Process (BP) cellular component movement 0 Informative Direct
Biological Process (BP) generation of neurons 8.849e-05 Informative Direct
Biological Process (BP) cellular membrane organization 8.939e-08 Informative Direct
Biological Process (BP) cell projection organization 0 Informative Direct
Biological Process (BP) cytoskeleton organization 0 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.0007916 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0 Informative Direct
Biological Process (BP) microtubule-based process 0 Informative Direct
Biological Process (BP) actin filament-based process 0 Informative Direct
Biological Process (BP) regulation of organelle organization 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) regulation of anatomical structure size 2.648e-13 Informative Direct
Biological Process (BP) muscle structure development 2.005e-12 Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 1.663e-11 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 3.054e-10 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 1.38e-09 Informative Direct
Biological Process (BP) regulation of growth 3.319e-08 Informative Direct
Biological Process (BP) cellular component disassembly 1.589e-07 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 2.265e-07 Informative Direct
Biological Process (BP) vesicle-mediated transport 2.625e-06 Informative Direct
Biological Process (BP) response to wounding 5.064e-05 Informative Direct
Biological Process (BP) biological adhesion 5.131e-05 Informative Direct
Biological Process (BP) localization of cell 0.0001714 Informative Direct
Biological Process (BP) regulation of nervous system development 0.0008991 Informative Direct
Biological Process (BP) cellular response to endogenous stimulus 0.1783 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.634 Informative Inherited
Biological Process (BP) protein localization to organelle 0.02546 Informative Inherited
Biological Process (BP) epithelium development 0.8865 Informative Inherited
Biological Process (BP) cardiovascular system development 1 Informative Inherited
Biological Process (BP) regulation of system process 0.6322 Informative Inherited
Biological Process (BP) organ morphogenesis 0.5747 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.001966 Informative Inherited
Biological Process (BP) cell cycle process 0.002444 Informative Inherited
Biological Process (BP) organelle assembly 0.8007 Informative Inherited
Biological Process (BP) protein complex assembly 1 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 0.5246 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.07609 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.02477 Informative Inherited
Biological Process (BP) regulation of cell development 0.01164 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.1837 Informative Inherited
Biological Process (BP) positive regulation of transport 0.9352 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.004863 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.9242 Informative Inherited
Biological Process (BP) sensory organ development 0.3034 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.367 Informative Inherited
Biological Process (BP) regulation of establishment of protein localization 0.5853 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.3316 Informative Inherited
Biological Process (BP) leukocyte activation 0.03015 Informative Inherited
Biological Process (BP) organelle localization 0.0736 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.2013 Informative Inherited
Biological Process (BP) tube development 0.1674 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.01358 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.2792 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.002854 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) reproductive system development 1 Informative Inherited
Biological Process (BP) response to nutrient levels 0.007835 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.07547 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.7308 Informative Inherited
Biological Process (BP) central nervous system development 0.01854 Informative Inherited
Biological Process (BP) cell-cell signaling 0.01992 Informative Inherited
Biological Process (BP) muscle tissue development 0.7533 Informative Inherited
Biological Process (BP) positive regulation of gene expression 1 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 1 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 1 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 1 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.05753 Informative Inherited
Biological Process (BP) single-organism behavior 0.1626 Informative Inherited
Biological Process (BP) sexual reproduction 0.08741 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.6444 Informative Inherited
Biological Process (BP) single organism reproductive process 0.7303 Informative Inherited
Biological Process (BP) protein transport 0.006612 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.8886 Informative Inherited
Biological Process (BP) phosphorylation 1 Informative Inherited
Biological Process (BP) regulation of ion transport 0.1409 Informative Inherited
Biological Process (BP) blood circulation 0.001508 Informative Inherited
Biological Process (BP) embryonic organ development 1 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.5621 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.3811 Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 2.458e-09 Highly Informative Direct
Biological Process (BP) negative regulation of protein complex disassembly 0 Highly Informative Direct
Biological Process (BP) negative regulation of cytoskeleton organization 0 Highly Informative Direct
Biological Process (BP) chemotaxis 0 Highly Informative Direct
Biological Process (BP) regulation of protein depolymerization 0 Highly Informative Direct
Biological Process (BP) cellular protein complex disassembly 0 Highly Informative Direct
Biological Process (BP) positive regulation of growth 2.722e-13 Highly Informative Direct
Biological Process (BP) muscle organ development 1.212e-12 Highly Informative Direct
Biological Process (BP) regulation of microtubule polymerization or depolymerization 1.281e-12 Highly Informative Direct
Biological Process (BP) actin filament organization 1.69e-12 Highly Informative Direct
Biological Process (BP) regulation of cell growth 6.455e-12 Highly Informative Direct
Biological Process (BP) cell junction organization 3.778e-10 Highly Informative Direct
Biological Process (BP) cell division 6.556e-09 Highly Informative Direct
Biological Process (BP) female gamete generation 6.375e-08 Highly Informative Direct
Biological Process (BP) wound healing 1.043e-07 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 3.914e-07 Highly Informative Direct
Biological Process (BP) maintenance of location 2.837e-06 Highly Informative Direct
Biological Process (BP) positive regulation of cell differentiation 1.253e-05 Highly Informative Direct
Biological Process (BP) plasma membrane organization 1.348e-05 Highly Informative Direct
Biological Process (BP) post-embryonic organ development 3.828e-05 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 5.065e-05 Highly Informative Direct
Biological Process (BP) locomotory behavior 5.126e-05 Highly Informative Direct
Biological Process (BP) sensory perception 0.0001548 Highly Informative Direct
Biological Process (BP) regulation of myeloid cell differentiation 0.0003595 Highly Informative Direct
Biological Process (BP) leukocyte migration 0.0004029 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 0.0006231 Highly Informative Direct
Biological Process (BP) renal system development 1 Highly Informative Inherited
Biological Process (BP) epithelial cell development 0.9106 Highly Informative Inherited
Biological Process (BP) regulation of cell size 0.01158 Highly Informative Inherited
Biological Process (BP) pattern specification process 1 Highly Informative Inherited
Biological Process (BP) negative regulation of protein transport 0.13 Highly Informative Inherited
Biological Process (BP) regulation of protein stability 0.1223 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.002993 Highly Informative Inherited
Biological Process (BP) regulation of endocytosis 1 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.003261 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.01908 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0.3383 Highly Informative Inherited
Biological Process (BP) developmental maturation 1 Highly Informative Inherited
Biological Process (BP) regulation of nucleocytoplasmic transport 0.3189 Highly Informative Inherited
Biological Process (BP) regulation of intracellular protein transport 0.007947 Highly Informative Inherited
Biological Process (BP) regulation of protein localization to nucleus 0.03422 Highly Informative Inherited
Biological Process (BP) regulation of protein catabolic process 0.2468 Highly Informative Inherited
Biological Process (BP) regulation of multicellular organism growth 0.001288 Highly Informative Inherited
Biological Process (BP) branching morphogenesis of an epithelial tube 0.008463 Highly Informative Inherited
Biological Process (BP) respiratory system development 0.004789 Highly Informative Inherited
Biological Process (BP) regulation of Rho GTPase activity 0.004109 Highly Informative Inherited
Biological Process (BP) positive regulation of Ras GTPase activity 0.4707 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane transport 0.05283 Highly Informative Inherited
Biological Process (BP) regulation of protein complex assembly 0.4272 Highly Informative Inherited
Biological Process (BP) cell adhesion 0.05929 Highly Informative Inherited
Biological Process (BP) cell fate commitment 0.4343 Highly Informative Inherited
Biological Process (BP) fruiting body development 0.001178 Highly Informative Inherited
Biological Process (BP) cell projection assembly 0.04805 Highly Informative Inherited
Biological Process (BP) regulation of transporter activity 0.01321 Highly Informative Inherited
Biological Process (BP) positive regulation of transcription, DNA-dependent 1 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.6516 Highly Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.002767 Highly Informative Inherited
Biological Process (BP) actomyosin structure organization 1 Highly Informative Inherited
Biological Process (BP) microtubule-based movement 0.9096 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in neuron differentiation 0.1556 Highly Informative Inherited
Biological Process (BP) cell projection morphogenesis 0.7319 Highly Informative Inherited
Biological Process (BP) axon development 0.6718 Highly Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 0.1034 Highly Informative Inherited
Biological Process (BP) protein localization to nucleus 0.7255 Highly Informative Inherited
Biological Process (BP) nuclear import 0.1817 Highly Informative Inherited
Biological Process (BP) protein import 0.4143 Highly Informative Inherited
Biological Process (BP) protein targeting to nucleus 0.7011 Highly Informative Inherited
Biological Process (BP) protein phosphorylation 0.981 Highly Informative Inherited
Biological Process (BP) establishment of protein localization to organelle 0.7991 Highly Informative Inherited
Biological Process (BP) regulation of blood pressure 0.009418 Highly Informative Inherited
Biological Process (BP) heart morphogenesis 0.3156 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 1 Highly Informative Inherited
Biological Process (BP) microtubule cytoskeleton organization 0.1178 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) anion binding 3.158e-05 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 5.736e-05 Moderately Informative Direct
Molecular Function (MF) oxidoreductase activity 0.7485 Moderately Informative Inherited
Molecular Function (MF) structural molecule activity 0.006332 Moderately Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0 Informative Direct
Molecular Function (MF) cofactor binding 0.003019 Informative Inherited
Molecular Function (MF) nucleotide binding 0.2322 Informative Inherited
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) GTPase regulator activity 0.3903 Informative Inherited
Molecular Function (MF) enzyme binding 0.2375 Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 0.09346 Informative Inherited
Molecular Function (MF) sulfur compound binding 0.03059 Informative Inherited
Molecular Function (MF) actin binding 0 Highly Informative Direct
Molecular Function (MF) Ras GTPase binding 0 Highly Informative Direct
Molecular Function (MF) monooxygenase activity 5.112e-11 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 5.38e-08 Highly Informative Direct
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0.0001317 Highly Informative Direct
Molecular Function (MF) heparin binding 0.0004661 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0.4739 Highly Informative Inherited
Molecular Function (MF) small GTPase regulator activity 0.7071 Highly Informative Inherited
Molecular Function (MF) tubulin binding 0.1603 Highly Informative Inherited
Molecular Function (MF) kinase binding 0.7009 Highly Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1.077e-09 Least Informative Direct
Cellular Component (CC) protein complex 5.985e-06 Least Informative Direct
Cellular Component (CC) membrane 0.0003995 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoskeleton 0 Moderately Informative Direct
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0.9344 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 0.02826 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 0.04765 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 1 Moderately Informative Inherited
Cellular Component (CC) extracellular region part 0.3971 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 0.003993 Moderately Informative Inherited
Cellular Component (CC) contractile fiber part 0 Informative Direct
Cellular Component (CC) cell cortex 0 Informative Direct
Cellular Component (CC) nuclear envelope 3.132e-15 Informative Direct
Cellular Component (CC) actin cytoskeleton 0 Informative Direct
Cellular Component (CC) cell leading edge 0 Informative Direct
Cellular Component (CC) endosome 0.7367 Informative Inherited
Cellular Component (CC) neuron projection 0.8417 Informative Inherited
Cellular Component (CC) cell-cell junction 1 Informative Inherited
Cellular Component (CC) integral to membrane 1 Informative Inherited
Cellular Component (CC) intrinsic to plasma membrane 1 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) extracellular matrix 0.04607 Informative Inherited
Cellular Component (CC) cell-substrate junction 4.787e-09 Highly Informative Direct
Cellular Component (CC) cortical cytoskeleton 1.411e-09 Highly Informative Direct
Cellular Component (CC) cytoplasmic microtubule 0 Highly Informative Direct
Cellular Component (CC) adherens junction 0 Highly Informative Direct
Cellular Component (CC) nuclear membrane 0 Highly Informative Direct
Cellular Component (CC) actin filament 0 Highly Informative Direct
Cellular Component (CC) spindle 1.006e-11 Highly Informative Direct
Cellular Component (CC) lateral plasma membrane 1.292e-08 Highly Informative Direct
Cellular Component (CC) growth cone 2.211e-07 Highly Informative Direct
Cellular Component (CC) apical plasma membrane 1.287e-06 Highly Informative Direct
Cellular Component (CC) recycling endosome 1.464e-06 Highly Informative Direct
Cellular Component (CC) contractile ring 2.278e-06 Highly Informative Direct
Cellular Component (CC) cell division site part 2.095e-05 Highly Informative Direct
Cellular Component (CC) neuromuscular junction 6.165e-05 Highly Informative Direct
Cellular Component (CC) endosomal part 0.3821 Highly Informative Inherited
Cellular Component (CC) cell body 0.3153 Highly Informative Inherited
Cellular Component (CC) basolateral plasma membrane 0.07253 Highly Informative Inherited
Cellular Component (CC) receptor complex 0.3179 Highly Informative Inherited
Cellular Component (CC) integral to plasma membrane 0.6867 Highly Informative Inherited
Cellular Component (CC) intermediate filament cytoskeleton 0.02471 Highly Informative Inherited
Cellular Component (CC) proteinaceous extracellular matrix 0.002946 Highly Informative Inherited

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.8196Least InformativeInherited
Disease Ontology (DO)neuromuscular disease0.002374InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.2656Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle physiology0.2732Moderately InformativeInherited
Phenotypic Abnormality (PA)Proximal muscle weakness7.775e-05InformativeDirect
Phenotypic Abnormality (PA)Abnormality of circulating enzyme level0.0003072InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.1235Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.8737Least InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.09316Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.2497Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal systemic arterial blood pressure0.07815InformativeInherited
Mammalian Phenotype (MP)abnormal exercise endurance0.0003245Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.001041Least InformativeInherited
Worm Phenotype (WP)locomotion variant0.0003113Moderately InformativeDirect
Worm Phenotype (WP)early embryonic lethal0.005971Moderately InformativeInherited
Worm Phenotype (WP)organ system development variant0.006891Moderately InformativeInherited
Worm Phenotype (WP)brood size variant9.212e-07InformativeDirect
Worm Phenotype (WP)body wall muscle morphology variant1.303e-06InformativeDirect
Worm Phenotype (WP)exploded through vulva0.0002208InformativeDirect
Worm Phenotype (WP)cell division variant0.1266InformativeInherited
Worm Phenotype (WP)body wall muscle myosin organization defective3.592e-05Highly InformativeDirect
Worm Phenotype (WP)cleavage furrow defective early emb4.908e-05Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)cell0.05027Least InformativeInherited
Fly Anatomy (FA)organ system0.4342Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)adult segment0.1015Moderately InformativeInherited
Fly Anatomy (FA)adult thorax0.2566Moderately InformativeInherited
Fly Anatomy (FA)thoracic segment0.807Moderately InformativeInherited
Fly Anatomy (FA)muscle system0.004825InformativeInherited
Fly Anatomy (FA)syncytium0.008284InformativeInherited
Fly Anatomy (FA)muscle cell0.0166InformativeInherited

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)portion of tissue0.2346Least InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.0001382Moderately InformativeDirect
Xenopus ANatomical entity (XAN)skeletal system0.0008152InformativeDirect
Xenopus ANatomical entity (XAN)bone tissue0.0001533Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCell cycle0Moderately InformativeDirect
Biological processMitosis0InformativeDirect
Biological processAngiogenesis5.829e-09InformativeDirect
Biological processCell adhesion2.643e-07InformativeDirect
Biological processWnt signaling pathway6.445e-07InformativeDirect
Biological processEndocytosis2.13e-05InformativeDirect
Biological processExocytosis8.774e-08Highly InformativeDirect
Biological processCilium biogenesis/degradation1.642e-07Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentNucleus1.899e-06Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentEndosome7.229e-05Moderately InformativeDirect
Cellular componentMicrotubule0InformativeDirect
Cellular componentSynapse1InformativeInherited
Cellular componentPostsynaptic cell membrane1.746e-06Highly InformativeDirect
Coding sequence diversityAlternative splicing0.0004555Least InformativeDirect
DomainRepeat0Least InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
DomainSH3 domain3.628e-15InformativeDirect
DomainSH2 domain1.639e-08InformativeDirect
DomainLeucine-rich repeat0.0002876InformativeDirect
DomainLIM domain0Highly InformativeDirect
Molecular functionZinc5.266e-07Least InformativeDirect
Molecular functionMetal-binding0.0004932Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionFlavoprotein3.262e-05Moderately InformativeDirect
Molecular functionActin-binding0InformativeDirect
Molecular functionCalmodulin-binding0InformativeDirect
Molecular functionFAD1.604e-07InformativeDirect
Post-translational modificationOxidoreductase1Moderately InformativeInherited
Post-translational modificationGuanine-nucleotide releasing factor0InformativeDirect
Post-translational modificationActin capping0Highly InformativeDirect
Post-translational modificationMonooxygenase6.55e-12Highly InformativeDirect
Post-translational modificationMuscle protein6.783e-12Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationAcetylation5.655e-08Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 17 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Calponin-homology domain, CH-domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 17 hidden Markov models representing the Calponin-homology domain, CH-domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]