SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.


Calponin-homology domain, CH-domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   CH domain-like [ 47575] (3)
Superfamily:   Calponin-homology domain, CH-domain [ 47576]
Families:   Calponin-homology domain, CH-domain [ 47577] (9)


Superfamily statistics
Genomes (507) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 12,765 32,034 21
Proteins 12,503 31,474 21


Functional annotation
General category General
Detailed category General

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular component organization or biogenesis0.019340Least InformativeInherited
Biological Process (BP)single-organism cellular process0.44170Least InformativeInherited
Biological Process (BP)system development0.45340.3309Moderately InformativeInherited
Biological Process (BP)supramolecular fiber organization0.00010290InformativeDirect
Biological Process (BP)actin filament-based process0.0002990InformativeDirect
Biological Process (BP)muscle structure development0.000033320Highly InformativeDirect
Molecular Function (MF)binding0.0082760Least InformativeInherited
Molecular Function (MF)cytoskeletal protein binding0.0000000000074870InformativeDirect
Cellular Component (CC)non-membrane-bounded organelle0.0000000071970Least InformativeDirect
Cellular Component (CC)intracellular organelle part0.088090Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.50260.003518Least InformativeInherited
Cellular Component (CC)cell projection0.00034840Moderately InformativeDirect
Cellular Component (CC)cytoskeleton0.0031910Moderately InformativeInherited
Cellular Component (CC)supramolecular polymer0.00000017410InformativeDirect
Cellular Component (CC)cytoplasmic region0.00011950InformativeDirect
Cellular Component (CC)contractile fiber part0.0000016710Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) biological regulation 0.00001948 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular developmental process 0 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.00007527 Moderately Informative Direct
Biological Process (BP) organelle organization 0 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.00000004958 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0 Moderately Informative Direct
Biological Process (BP) cellular localization 0.0000000000821 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.000000003492 Moderately Informative Direct
Biological Process (BP) response to external stimulus 0.000002637 Moderately Informative Direct
Biological Process (BP) cellular component assembly 0.00001779 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.00009837 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.5023 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) system development 0.3309 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.04341 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.4897 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.8925 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.8052 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.008655 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.5107 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.2409 Moderately Informative Inherited
Biological Process (BP) cell communication 0.03306 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.038 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) oxidation-reduction process 0.00608 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.08016 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.05375 Moderately Informative Inherited
Biological Process (BP) reproduction 0.004838 Moderately Informative Inherited
Biological Process (BP) single organism signaling 0.9717 Moderately Informative Inherited
Biological Process (BP) supramolecular fiber organization 0 Informative Direct
Biological Process (BP) actin filament-based process 0 Informative Direct
Biological Process (BP) cytoskeleton organization 0 Informative Direct
Biological Process (BP) tissue development 0.000000000000003764 Informative Direct
Biological Process (BP) cell development 0 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0 Informative Direct
Biological Process (BP) cellular component morphogenesis 0 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) microtubule-based process 0 Informative Direct
Biological Process (BP) organelle assembly 0 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0.000000000000259 Informative Direct
Biological Process (BP) regulation of growth 0.0000000000003763 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.000000000004119 Informative Direct
Biological Process (BP) regulation of organelle organization 0.00000001575 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.00000001903 Informative Direct
Biological Process (BP) behavior 0.00000004299 Informative Direct
Biological Process (BP) multi-organism reproductive process 0.000001307 Informative Direct
Biological Process (BP) positive regulation of developmental process 0.000006349 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0.00004097 Informative Direct
Biological Process (BP) regulation of cell differentiation 0.0000478 Informative Direct
Biological Process (BP) cell cycle process 0.0001757 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0.0005493 Informative Direct
Biological Process (BP) regulation of locomotion 0.0005651 Informative Direct
Biological Process (BP) regulation of transmembrane transport 0.02699 Informative Inherited
Biological Process (BP) regulation of ion transport 0.009232 Informative Inherited
Biological Process (BP) regulation of system process 0.009608 Informative Inherited
Biological Process (BP) cellular response to hormone stimulus 0.004779 Informative Inherited
Biological Process (BP) reproductive system development 1 Informative Inherited
Biological Process (BP) organelle localization 0.1246 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.001054 Informative Inherited
Biological Process (BP) generation of neurons 0.1014 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.0157 Informative Inherited
Biological Process (BP) membrane organization 0.9199 Informative Inherited
Biological Process (BP) sensory organ development 0.2831 Informative Inherited
Biological Process (BP) regulation of peptide transport 0.9307 Informative Inherited
Biological Process (BP) positive regulation of transport 0.7648 Informative Inherited
Biological Process (BP) regulation of cellular localization 0.1599 Informative Inherited
Biological Process (BP) regulation of establishment of protein localization 0.6983 Informative Inherited
Biological Process (BP) regulation of catabolic process 0.4914 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.827 Informative Inherited
Biological Process (BP) protein localization to organelle 0.7022 Informative Inherited
Biological Process (BP) regulation of protein modification process 0.0767 Informative Inherited
Biological Process (BP) regulation of phosphorylation 0.1158 Informative Inherited
Biological Process (BP) single-organism intracellular transport 0.102 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.04413 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.03784 Informative Inherited
Biological Process (BP) cell activation 0.9369 Informative Inherited
Biological Process (BP) central nervous system development 0.3493 Informative Inherited
Biological Process (BP) cell-cell signaling 0.01488 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.002734 Informative Inherited
Biological Process (BP) positive regulation of gene expression 1 Informative Inherited
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) regulation of transcription, DNA-templated 1 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 1 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.4547 Informative Inherited
Biological Process (BP) embryo development 1 Informative Inherited
Biological Process (BP) response to extracellular stimulus 0.5219 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) system process 1 Informative Inherited
Biological Process (BP) single organism reproductive process 0.5759 Informative Inherited
Biological Process (BP) multicellular organism reproduction 1 Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 0.5711 Informative Inherited
Biological Process (BP) regulation of cell cycle 0.8851 Informative Inherited
Biological Process (BP) DNA metabolic process 1 Informative Inherited
Biological Process (BP) post-embryonic development 0.005599 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.4618 Informative Inherited
Biological Process (BP) circulatory system development 1 Informative Inherited
Biological Process (BP) muscle structure development 0 Highly Informative Direct
Biological Process (BP) negative regulation of cytoskeleton organization 0 Highly Informative Direct
Biological Process (BP) regulation of microtubule-based process 0 Highly Informative Direct
Biological Process (BP) positive regulation of growth 0 Highly Informative Direct
Biological Process (BP) negative regulation of supramolecular fiber organization 0 Highly Informative Direct
Biological Process (BP) regulation of protein complex disassembly 0 Highly Informative Direct
Biological Process (BP) cellular component assembly involved in morphogenesis 0 Highly Informative Direct
Biological Process (BP) plasma membrane bounded cell projection organization 0 Highly Informative Direct
Biological Process (BP) chemotaxis 0 Highly Informative Direct
Biological Process (BP) positive regulation of cell development 0.00000000001594 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 0.00000000004843 Highly Informative Direct
Biological Process (BP) locomotory behavior 0.000000005088 Highly Informative Direct
Biological Process (BP) female gamete generation 0.00000001245 Highly Informative Direct
Biological Process (BP) positive regulation of nervous system development 0.00000005007 Highly Informative Direct
Biological Process (BP) positive regulation of cellular component biogenesis 0.0000003326 Highly Informative Direct
Biological Process (BP) negative regulation of homeostatic process 0.000004459 Highly Informative Direct
Biological Process (BP) biological adhesion 0.000006895 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.000009149 Highly Informative Direct
Biological Process (BP) cellular component disassembly 0.00001106 Highly Informative Direct
Biological Process (BP) actomyosin structure organization 0.00003386 Highly Informative Direct
Biological Process (BP) DNA methylation or demethylation 0.00007469 Highly Informative Direct
Biological Process (BP) regulation of cell growth 0.00009752 Highly Informative Direct
Biological Process (BP) positive regulation of transmembrane transport 0.0002253 Highly Informative Direct
Biological Process (BP) hemostasis 0.0002422 Highly Informative Direct
Biological Process (BP) wound healing 0.0002442 Highly Informative Direct
Biological Process (BP) regulation of cation transmembrane transport 0.0004301 Highly Informative Direct
Biological Process (BP) positive regulation of transporter activity 0.0008102 Highly Informative Direct
Biological Process (BP) maintenance of location 0.0009013 Highly Informative Direct
Biological Process (BP) negative regulation of immune system process 0.06285 Highly Informative Inherited
Biological Process (BP) protein localization to membrane 0.002252 Highly Informative Inherited
Biological Process (BP) epithelial cell differentiation 0.7693 Highly Informative Inherited
Biological Process (BP) kidney development 1 Highly Informative Inherited
Biological Process (BP) cell division 0.008493 Highly Informative Inherited
Biological Process (BP) actin filament organization 0.5261 Highly Informative Inherited
Biological Process (BP) neuron development 1 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 1 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.09177 Highly Informative Inherited
Biological Process (BP) tube morphogenesis 0.03021 Highly Informative Inherited
Biological Process (BP) anatomical structure homeostasis 0.005979 Highly Informative Inherited
Biological Process (BP) cell maturation 0.9979 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.002249 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular protein localization 0.004679 Highly Informative Inherited
Biological Process (BP) positive regulation of protein transport 0.2646 Highly Informative Inherited
Biological Process (BP) regulation of protein import into nucleus 0.1561 Highly Informative Inherited
Biological Process (BP) negative regulation of catabolic process 0.001963 Highly Informative Inherited
Biological Process (BP) microtubule cytoskeleton organization 0.8405 Highly Informative Inherited
Biological Process (BP) regulation of protein polymerization 0.01176 Highly Informative Inherited
Biological Process (BP) negative regulation of protein complex assembly 0.1604 Highly Informative Inherited
Biological Process (BP) response to nutrient levels 0.002482 Highly Informative Inherited
Biological Process (BP) cellular response to extracellular stimulus 0.001188 Highly Informative Inherited
Biological Process (BP) regulation of cell size 0.02637 Highly Informative Inherited
Biological Process (BP) negative regulation of growth 0.01735 Highly Informative Inherited
Biological Process (BP) coagulation 0.08449 Highly Informative Inherited
Biological Process (BP) cell projection assembly 0.6244 Highly Informative Inherited
Biological Process (BP) brain development 0.4771 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.04193 Highly Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 1 Highly Informative Inherited
Biological Process (BP) positive regulation of transcription, DNA-templated 1 Highly Informative Inherited
Biological Process (BP) appendage development 0.0932 Highly Informative Inherited
Biological Process (BP) post-embryonic animal morphogenesis 0.004309 Highly Informative Inherited
Biological Process (BP) germ cell development 1 Highly Informative Inherited
Biological Process (BP) neurological system process 0.6663 Highly Informative Inherited
Biological Process (BP) pattern specification process 1 Highly Informative Inherited
Biological Process (BP) endomembrane system organization 0.025 Highly Informative Inherited
Biological Process (BP) muscle system process 0.03499 Highly Informative Inherited
Biological Process (BP) macromolecule methylation 0.08548 Highly Informative Inherited
Biological Process (BP) regulation of blood pressure 0.006634 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 0.9344 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) anion binding 0.000248 Moderately Informative Direct
Molecular Function (MF) small molecule binding 1 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 1 Moderately Informative Inherited
Molecular Function (MF) structural molecule activity 0.01784 Moderately Informative Inherited
Molecular Function (MF) molecular function regulator 0.003724 Moderately Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0 Informative Direct
Molecular Function (MF) macromolecular complex binding 0 Informative Direct
Molecular Function (MF) protein dimerization activity 0.00000004782 Informative Direct
Molecular Function (MF) coenzyme binding 0.0000001697 Informative Direct
Molecular Function (MF) identical protein binding 0.000002098 Informative Direct
Molecular Function (MF) enzyme binding 0.8572 Informative Inherited
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) sulfur compound binding 0.07691 Informative Inherited
Molecular Function (MF) actin filament binding 0.00000001389 Highly Informative Direct
Molecular Function (MF) protein homodimerization activity 8.425e-16 Highly Informative Direct
Molecular Function (MF) monooxygenase activity 0.000000007091 Highly Informative Direct
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0.00000007039 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 0.0000001669 Highly Informative Direct
Molecular Function (MF) heparin binding 0.0003167 Highly Informative Direct
Molecular Function (MF) cell adhesion molecule binding 0.0005591 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0.5086 Highly Informative Inherited
Molecular Function (MF) transcription factor activity, transcription factor binding 0.187 Highly Informative Inherited
Molecular Function (MF) small GTPase binding 0.6768 Highly Informative Inherited
Molecular Function (MF) tubulin binding 0.6502 Highly Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0 Least Informative Direct
Cellular Component (CC) membrane 0.000000000001621 Least Informative Direct
Cellular Component (CC) macromolecular complex 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.003518 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) vesicle 0.01438 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 0.9546 Moderately Informative Inherited
Cellular Component (CC) extracellular region part 0.5493 Moderately Informative Inherited
Cellular Component (CC) membrane protein complex 0.4772 Moderately Informative Inherited
Cellular Component (CC) intrinsic component of membrane 1 Moderately Informative Inherited
Cellular Component (CC) bounding membrane of organelle 0.1335 Moderately Informative Inherited
Cellular Component (CC) whole membrane 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) supramolecular polymer 0 Informative Direct
Cellular Component (CC) cytoplasmic region 0 Informative Direct
Cellular Component (CC) actin cytoskeleton 0 Informative Direct
Cellular Component (CC) apical part of cell 0.0000000007605 Informative Direct
Cellular Component (CC) nuclear envelope 0.0000001043 Informative Direct
Cellular Component (CC) plasma membrane region 0.00001639 Informative Direct
Cellular Component (CC) synapse 0.00007629 Informative Direct
Cellular Component (CC) neuron projection 1 Informative Inherited
Cellular Component (CC) endosome 0.5616 Informative Inherited
Cellular Component (CC) plasma membrane bounded cell projection part 1 Informative Inherited
Cellular Component (CC) plasma membrane protein complex 0.002464 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) outer membrane 0.05009 Informative Inherited
Cellular Component (CC) contractile fiber part 0 Highly Informative Direct
Cellular Component (CC) lamellipodium 0 Highly Informative Direct
Cellular Component (CC) lateral plasma membrane 0 Highly Informative Direct
Cellular Component (CC) cytoplasmic microtubule 0 Highly Informative Direct
Cellular Component (CC) cortical actin cytoskeleton 0 Highly Informative Direct
Cellular Component (CC) sarcolemma 0 Highly Informative Direct
Cellular Component (CC) growth cone 0 Highly Informative Direct
Cellular Component (CC) nuclear membrane 0.0000000317 Highly Informative Direct
Cellular Component (CC) cell-substrate adherens junction 0.0000006506 Highly Informative Direct
Cellular Component (CC) cell division site part 0.000005189 Highly Informative Direct
Cellular Component (CC) spindle 0.00001002 Highly Informative Direct
Cellular Component (CC) receptor complex 0.0002474 Highly Informative Direct
Cellular Component (CC) apical plasma membrane 0.000397 Highly Informative Direct
Cellular Component (CC) neuronal cell body 1 Highly Informative Inherited
Cellular Component (CC) cell-cell junction 1 Highly Informative Inherited
Cellular Component (CC) basolateral plasma membrane 0.2577 Highly Informative Inherited
Cellular Component (CC) intrinsic component of plasma membrane 1 Highly Informative Inherited

Document: GO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the musculature0.03734Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.1364Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.3307Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the face0.4317Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of long bone morphology0.1621Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle physiology0.2573Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle morphology0.4027Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digit0.5225Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the hand0.9955Moderately InformativeInherited
Phenotypic Abnormality (PA)Proximal muscle weakness0.0007982InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the musculature of the limbs0.01772InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the thorax0.03004InformativeInherited
Phenotypic Abnormality (PA)Abnormal facial shape0.1788InformativeInherited
Phenotypic Abnormality (PA)Abnormality of phalanx of finger0.1873InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal muscles0.2608InformativeInherited
Phenotypic Abnormality (PA)Abnormality of upper limb bone0.2888InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle size0.3085InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the calf musculature0.00001479Highly InformativeDirect
Phenotypic Abnormality (PA)Broad thumb0.0002218Highly InformativeDirect
Phenotypic Abnormality (PA)Flat face0.0005708Highly InformativeDirect
Phenotypic Abnormality (PA)Scapular winging0.0009651Highly InformativeDirect
Phenotypic Abnormality (PA)Distal amyotrophy0.1337Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.12Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.5394Least InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.02442Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.1121Moderately InformativeInherited
Mammalian Phenotype (MP)decreased hematopoietic cell number0.24Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte cell number0.3635Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.4639Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.7006Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.7826Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mature B cell morphology0.1098InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation0.3169InformativeInherited
Mammalian Phenotype (MP)abnormal intestine morphology0.3456InformativeInherited
Mammalian Phenotype (MP)increased leukocyte cell number0.6747InformativeInherited
Mammalian Phenotype (MP)abnormal exercise endurance0.0001495Highly InformativeDirect
Mammalian Phenotype (MP)abnormal transitional stage T1 B cell morphology0.0001604Highly InformativeDirect
Mammalian Phenotype (MP)abnormal transitional stage T2 B cell morphology0.0002197Highly InformativeDirect
Mammalian Phenotype (MP)intestinal ulcer0.0008029Highly InformativeDirect
Mammalian Phenotype (MP)decreased immature B cell number0.1479Highly InformativeInherited
Mammalian Phenotype (MP)increased B cell number0.2542Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell morphology variant0.0000002505Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.00004692Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.000594Least InformativeDirect
Worm Phenotype (WP)cell development variant0.04863Least InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.001718Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.4452Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.4894Moderately InformativeInherited
Worm Phenotype (WP)brood size variant0.0000006155InformativeDirect
Worm Phenotype (WP)protein degradation variant0.00004824InformativeDirect
Worm Phenotype (WP)muscle cell physiology variant0.0000912InformativeDirect
Worm Phenotype (WP)cytokinesis variant emb0.0001356InformativeDirect
Worm Phenotype (WP)neuronal outgrowth variant0.0004868InformativeDirect
Worm Phenotype (WP)epithelial system development variant0.05124InformativeInherited
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.7018InformativeInherited
Worm Phenotype (WP)cleavage furrow defective0.000002665Highly InformativeDirect
Worm Phenotype (WP)axon guidance variant0.0001373Highly InformativeDirect
Worm Phenotype (WP)exploded through vulva0.0003378Highly InformativeDirect
Worm Phenotype (WP)cytokinesis defective early emb0.006518Highly InformativeInherited
Worm Phenotype (WP)body wall muscle thick filament variant0.2044Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)anatomical cluster0.5927Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.8642Least InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.00525Moderately InformativeInherited
Xenopus ANatomical entity (XAN)connective tissue0.0007123InformativeDirect
Xenopus ANatomical entity (XAN)skeletal system0.005295InformativeInherited
Xenopus ANatomical entity (XAN)solid compound organ0.06681InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0.00000000000001202Least InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation of one atom of oxygen0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCell cycle0Moderately InformativeDirect
Biological processMitosis0InformativeDirect
Biological processAngiogenesis0.00000001128InformativeDirect
Biological processEndocytosis0.0000002104InformativeDirect
Biological processCell adhesion0.0000005874InformativeDirect
Biological processWnt signaling pathway0.000001082InformativeDirect
Biological processExocytosis0.0000001839Highly InformativeDirect
Biological processCilium biogenesis/degradation0.000001331Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentNucleus0.00004585Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentEndosome0.0000003003Moderately InformativeDirect
Cellular componentMicrotubule0InformativeDirect
Cellular componentSynapse1InformativeInherited
Cellular componentPostsynaptic cell membrane0.000004422Highly InformativeDirect
Coding sequence diversityAlternative splicing0.0004454Least InformativeDirect
DomainRepeat0Least InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
DomainSH3 domain0.00000000000001155InformativeDirect
DomainSH2 domain0.00000002857InformativeDirect
DomainLeucine-rich repeat0.0006008InformativeDirect
DomainLIM domain0Highly InformativeDirect
Molecular functionZinc0.000009389Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionFlavoprotein0.0002291Moderately InformativeDirect
Molecular functionFAD0.000002373InformativeDirect
Post-translational modificationOxidoreductase1Moderately InformativeInherited
Post-translational modificationActin-binding0InformativeDirect
Post-translational modificationCalmodulin-binding0InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor0InformativeDirect
Post-translational modificationActin capping4.405e-16Highly InformativeDirect
Post-translational modificationMuscle protein0.00000000001296Highly InformativeDirect
Post-translational modificationMonooxygenase0.00000000006192Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationAcetylation0.000000000004752Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 17 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Calponin-homology domain, CH-domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 17 hidden Markov models representing the Calponin-homology domain, CH-domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]