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Calponin-homology domain, CH-domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   CH domain-like [ 47575] (3)
Superfamily:   Calponin-homology domain, CH-domain [ 47576]
Families:   Calponin-homology domain, CH-domain [ 47577] (9)


Superfamily statistics
Genomes (509) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 12,940 39,216 21
Proteins 12,673 38,606 21


Functional annotation
General category General
Detailed category General

Document:
Function annotation of SCOP domain superfamilies

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.1194Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature0.1436Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.1715Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the skeletal system0.5331Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.0273Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system physiology0.03252Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the thorax0.0883Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper limb0.1267Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system electrophysiology0.04345InformativeInherited
Phenotypic Abnormality (PA)Lipodystrophy0.00008432Highly InformativeDirect
Phenotypic Abnormality (PA)Atrioventricular block0.0008247Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.1193Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.5385Least InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.02423Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.1101Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.3981Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.4629Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.702Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.7829Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mature B cell morphology0.1096InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation0.3179InformativeInherited
Mammalian Phenotype (MP)abnormal intestine morphology0.3477InformativeInherited
Mammalian Phenotype (MP)increased leukocyte cell number0.6736InformativeInherited
Mammalian Phenotype (MP)abnormal exercise endurance0.0001406Highly InformativeDirect
Mammalian Phenotype (MP)abnormal transitional stage T1 B cell morphology0.0001609Highly InformativeDirect
Mammalian Phenotype (MP)abnormal transitional stage T2 B cell morphology0.0002202Highly InformativeDirect
Mammalian Phenotype (MP)intestinal ulcer0.000804Highly InformativeDirect
Mammalian Phenotype (MP)decreased immature B cell number0.1487Highly InformativeInherited
Mammalian Phenotype (MP)increased B cell number0.2536Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell morphology variant0.0000003651Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.00005362Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.0007162Least InformativeDirect
Worm Phenotype (WP)cell development variant0.05567Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.1984Least InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.001872Moderately InformativeInherited
Worm Phenotype (WP)metabolic pathway variant0.007178Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.4633Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.5387Moderately InformativeInherited
Worm Phenotype (WP)reduced brood size0.0000002613InformativeDirect
Worm Phenotype (WP)protein degradation variant0.00005677InformativeDirect
Worm Phenotype (WP)muscle cell physiology variant0.00008361InformativeDirect
Worm Phenotype (WP)cytokinesis variant emb0.0001533InformativeDirect
Worm Phenotype (WP)axon outgrowth variant0.0009258InformativeDirect
Worm Phenotype (WP)epithelial system development variant0.05155InformativeInherited
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.6894InformativeInherited
Worm Phenotype (WP)cleavage furrow defective0.000003384Highly InformativeDirect
Worm Phenotype (WP)axon guidance variant0.0001506Highly InformativeDirect
Worm Phenotype (WP)exploded through vulva0.0003495Highly InformativeDirect
Worm Phenotype (WP)cytokinesis defective early emb0.006817Highly InformativeInherited
Worm Phenotype (WP)body wall muscle thick filament variant0.209Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)somatic cell0.06712Least InformativeInherited
Fly Anatomy (FA)adult0.07155Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)adult segment0.1909Moderately InformativeInherited
Fly Anatomy (FA)adult thorax0.4903Moderately InformativeInherited
Fly Anatomy (FA)thoracic segment0.9377Moderately InformativeInherited
Fly Anatomy (FA)muscle system0.002464InformativeInherited
Fly Anatomy (FA)syncytium0.002867InformativeInherited
Fly Anatomy (FA)flight muscle0.0003087Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0.00000000000001326Least InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation of one atom of oxygen0Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 46 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Calponin-homology domain, CH-domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 46 hidden Markov models representing the Calponin-homology domain, CH-domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]