SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.


GST C-terminal domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   GST C-terminal domain-like [ 47615]
Superfamily:   GST C-terminal domain-like [ 47616] (2)
Families:   Glutathione S-transferase (GST), C-terminal domain [ 47617] (18)
  Arc1p N-terminal domain-like [ 158491]


Superfamily statistics
Genomes (1,853) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 28,342 115,255 104
Proteins 28,080 114,577 104


Functional annotation
General category General
Detailed category Small molecule binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) organonitrogen compound metabolic process 0.000000000000007296 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.00000000009223 Least Informative Direct
Biological Process (BP) cellular nitrogen compound metabolic process 0.0000000008234 Least Informative Direct
Biological Process (BP) response to stimulus 0.00001121 Least Informative Direct
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) peptide metabolic process 0 Moderately Informative Direct
Biological Process (BP) single-organism catabolic process 0.0000000004104 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0.000001046 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 0.4553 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) ion transport 0.9913 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) nitrogen compound transport 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.001567 Moderately Informative Inherited
Biological Process (BP) amide biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.002937 Moderately Informative Inherited
Biological Process (BP) gene expression 0.01984 Moderately Informative Inherited
Biological Process (BP) cellular modified amino acid metabolic process 0 Informative Direct
Biological Process (BP) secondary metabolic process 0 Informative Direct
Biological Process (BP) tRNA metabolic process 0.0000000006409 Informative Direct
Biological Process (BP) response to oxidative stress 0.00008997 Informative Direct
Biological Process (BP) cellular ketone metabolic process 0.0005216 Informative Direct
Biological Process (BP) sulfur compound biosynthetic process 0.06453 Informative Inherited
Biological Process (BP) response to metal ion 0.07664 Informative Inherited
Biological Process (BP) fatty acid metabolic process 0.1352 Informative Inherited
Biological Process (BP) monosaccharide metabolic process 0.0281 Informative Inherited
Biological Process (BP) anion transport 0.06896 Informative Inherited
Biological Process (BP) protein localization to organelle 0.2292 Informative Inherited
Biological Process (BP) intracellular transport 1 Informative Inherited
Biological Process (BP) mitochondrion organization 0.001087 Informative Inherited
Biological Process (BP) protein transport 0.8029 Informative Inherited
Biological Process (BP) xenobiotic metabolic process 0 Highly Informative Direct
Biological Process (BP) detoxification 0 Highly Informative Direct
Biological Process (BP) glutathione metabolic process 0 Highly Informative Direct
Biological Process (BP) establishment of protein localization to mitochondrion 0.00000252 Highly Informative Direct
Biological Process (BP) benzene-containing compound metabolic process 0.00007526 Highly Informative Direct
Biological Process (BP) mitochondrial transport 0.0001287 Highly Informative Direct
Biological Process (BP) response to arsenic-containing substance 0.0001604 Highly Informative Direct
Biological Process (BP) protein targeting 0.002325 Highly Informative Inherited
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) anion binding 0.001185 Moderately Informative Inherited
Molecular Function (MF) isomerase activity 0.1463 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity 0.4357 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 1 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) amide binding 0 Informative Direct
Molecular Function (MF) transferase activity, transferring alkyl or aryl (other than methyl) groups 0 Informative Direct
Molecular Function (MF) sulfur compound binding 0 Informative Direct
Molecular Function (MF) identical protein binding 0.0002947 Informative Direct
Molecular Function (MF) protein dimerization activity 0.0013 Informative Inherited
Molecular Function (MF) anion transmembrane transporter activity 0.00168 Informative Inherited
Molecular Function (MF) RNA binding 0.7903 Informative Inherited
Molecular Function (MF) passive transmembrane transporter activity 0.0475 Informative Inherited
Molecular Function (MF) ligase activity 0.006214 Informative Inherited
Molecular Function (MF) modified amino acid binding 0 Highly Informative Direct
Molecular Function (MF) peptide binding 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on a sulfur group of donors 0.000000000000007771 Highly Informative Direct
Molecular Function (MF) inorganic anion transmembrane transporter activity 0.000001777 Highly Informative Direct
Molecular Function (MF) protein homodimerization activity 0.00002804 Highly Informative Direct
Molecular Function (MF) drug binding 0.00003732 Highly Informative Direct
Molecular Function (MF) translation factor activity, RNA binding 0.00008988 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-NH group of donors 0.005616 Highly Informative Inherited
Molecular Function (MF) ion channel activity 0.02213 Highly Informative Inherited
Molecular Function (MF) peroxidase activity 0.9989 Highly Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) protein complex 0.1857 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cell projection 1 Moderately Informative Inherited
Cellular Component (CC) vesicle 0.356 Moderately Informative Inherited
Cellular Component (CC) extracellular region part 0.7926 Moderately Informative Inherited
Cellular Component (CC) bounding membrane of organelle 0.06076 Moderately Informative Inherited
Cellular Component (CC) whole membrane 0.06336 Moderately Informative Inherited
Cellular Component (CC) mitochondrial envelope 0.1555 Moderately Informative Inherited
Cellular Component (CC) outer membrane 0.00000003673 Informative Direct
Cellular Component (CC) extracellular organelle 0.0008688 Informative Direct
Cellular Component (CC) plasma membrane bounded cell projection part 0.7977 Informative Inherited
Cellular Component (CC) cilium 0.186 Informative Inherited
Cellular Component (CC) extracellular space 0.2734 Informative Inherited
Cellular Component (CC) neuron projection 1 Informative Inherited
Cellular Component (CC) mitochondrial outer membrane 0.00003853 Highly Informative Direct
Cellular Component (CC) extracellular exosome 0.0005684 Highly Informative Direct
Cellular Component (CC) dendrite 0.2647 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Isomerases0.6406Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Acting on a sulfur group of donors0.00000003662Moderately InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0.3581Moderately InformativeInherited
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than meth1Moderately InformativeInherited
Enzyme Commission (EC)Glutathione transferase0Highly InformativeDirect
Enzyme Commission (EC)Other intramolecular oxidoreductases0.000000000000002558Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.6051Least InformativeInherited
Biological processIon transport0.0002858Moderately InformativeDirect
Biological processProtein transport0.0005585Moderately InformativeDirect
Biological processLipid metabolism0.8254Moderately InformativeInherited
Biological processProtein biosynthesis0.000000000000001442InformativeDirect
Biological processStress response0.000000001918InformativeDirect
Biological processFatty acid metabolism0.02575InformativeInherited
Biological processDetoxification0Highly InformativeDirect
Biological processProstaglandin biosynthesis0Highly InformativeDirect
Biological processPhenylalanine catabolism0Highly InformativeDirect
Biological processNitrate assimilation0.00000000000001864Highly InformativeDirect
Biological processAuxin signaling pathway0.0000000000004861Highly InformativeDirect
Cellular componentCytoplasm0.0000000002994Least InformativeDirect
Cellular componentMitochondrion0.00000002766Moderately InformativeDirect
Cellular componentMitochondrion outer membrane0InformativeDirect
Molecular functionChloride0InformativeDirect
Molecular functionChloride channel0Highly InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationOxidoreductase1Moderately InformativeInherited
Post-translational modificationIon channel0InformativeDirect
Post-translational modificationElongation factor0Highly InformativeDirect
Post-translational modificationVoltage-gated channel0Highly InformativeDirect
Post-translational modificationPeroxidase0.0000005511Highly InformativeDirect
Post-translational modificationAcetylation0Least InformativeDirect
Post-translational modificationPhosphoprotein0.00000008135Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR010987 SSF47616 Protein matches
Abstract

In eukaryotes, glutathione S-transferases (GSTs) participate in the detoxification of reactive electrophilic compounds by catalysing their conjugation to glutathione. GST is found as a domain in S-crystallins from squid, and proteins with no known GST activity, such as eukaryotic elongation factors 1-gamma and the HSP26 family of stress-related proteins, which include auxin-regulated proteins in plants and stringent starvation proteins in Escherichia coli. The major lens polypeptide of cephalopods is also a GST [PubMed9074797]. Bacterial GSTs of known function often have a specific, growth-supporting role in biodegradative metabolism: epoxide ring opening and tetrachlorohydroquinone reductive dehalogenation are two examples of the reactions catalysed by these bacterial GSTs. Some regulatory proteins, like the stringent starvation proteins, also belong to the GST family [PubMed9045797]. GST seems to be absent from Archaea in which gamma-glutamylcysteine substitute to glutathione as major thiol.

Glutathione S-transferases form homodimers, but in eukaryotes can also form heterodimers of the A1 and A2 or YC1 and YC2 subunits. The homodimeric enzymes display a conserved structural fold. Each monomer is composed of a distinct N-terminal sub-domain, which adopts the thioredoxin fold, and a C-terminal all-helical sub-domain, which adopts a 4-helical bundle fold. This entry is the C-terminal domain.

Glutaredoxin 2 (Grx2), glutathione-dependent disulphide oxidoreductases, is structurally similar to GSTs, even though they lack any sequence similarity. Grx2 is also composed of N and C terminal subdomains. It is thought that the primary function of Grx2 is to catalyse reversible glutathionylation of proteins with glutathione in cellular redox regulation including the response to oxidative stress. Grx2 is dissimilar to other glutaredoxins apart from containing the conserved active site residues [PubMed14713336].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 52 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a GST C-terminal domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 52 hidden Markov models representing the GST C-terminal domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]