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GST C-terminal domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   GST C-terminal domain-like [ 47615]
Superfamily:   GST C-terminal domain-like [ 47616] (2)
Families:   Glutathione S-transferase (GST), C-terminal domain [ 47617] (18)
  Arc1p N-terminal domain-like [ 158491]


Superfamily statistics
Genomes (1,848) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 28,156 87,307 104
Proteins 27,899 87,112 104


Functional annotation
General category General
Detailed category Small molecule binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) organonitrogen compound metabolic process 0 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.000000002987 Least Informative Direct
Biological Process (BP) cellular nitrogen compound metabolic process 0.00000009805 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.1783 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) peptide metabolic process 0 Moderately Informative Direct
Biological Process (BP) single-organism catabolic process 0.000000000004927 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0.00000006291 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.3139 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.8677 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) response to stress 0.1665 Moderately Informative Inherited
Biological Process (BP) ion transport 0.9378 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.01673 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.05923 Moderately Informative Inherited
Biological Process (BP) amide biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) gene expression 0.1829 Moderately Informative Inherited
Biological Process (BP) secondary metabolic process 0 Informative Direct
Biological Process (BP) cellular modified amino acid metabolic process 0 Informative Direct
Biological Process (BP) tRNA metabolic process 0.0000002475 Informative Direct
Biological Process (BP) response to inorganic substance 0.000005695 Informative Direct
Biological Process (BP) response to oxidative stress 0.000246 Informative Direct
Biological Process (BP) sulfur compound biosynthetic process 0.0442 Informative Inherited
Biological Process (BP) protein localization to organelle 0.2157 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.6047 Informative Inherited
Biological Process (BP) cellular ketone metabolic process 0.001205 Informative Inherited
Biological Process (BP) fatty acid metabolic process 0.28 Informative Inherited
Biological Process (BP) monosaccharide metabolic process 0.01348 Informative Inherited
Biological Process (BP) anion transport 0.05332 Informative Inherited
Biological Process (BP) mitochondrion organization 0.0153 Informative Inherited
Biological Process (BP) protein targeting 0.07913 Informative Inherited
Biological Process (BP) organelle fission 0.2604 Informative Inherited
Biological Process (BP) glutathione metabolic process 0 Highly Informative Direct
Biological Process (BP) cellular response to xenobiotic stimulus 0 Highly Informative Direct
Biological Process (BP) detoxification 0.000000006985 Highly Informative Direct
Biological Process (BP) protein localization to mitochondrion 0.000004287 Highly Informative Direct
Biological Process (BP) response to arsenic-containing substance 0.00001253 Highly Informative Direct
Biological Process (BP) mitochondrial transport 0.0002207 Highly Informative Direct
Biological Process (BP) benzene-containing compound metabolic process 0.0004195 Highly Informative Direct
Biological Process (BP) endocytosis 0.06346 Highly Informative Inherited
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) anion binding 0.00165 Moderately Informative Inherited
Molecular Function (MF) protein binding 1 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity 0.3463 Moderately Informative Inherited
Molecular Function (MF) isomerase activity 0.2162 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 1 Moderately Informative Inherited
Molecular Function (MF) amide binding 0 Informative Direct
Molecular Function (MF) sulfur compound binding 0 Informative Direct
Molecular Function (MF) transferase activity, transferring alkyl or aryl (other than methyl) groups 0 Informative Direct
Molecular Function (MF) identical protein binding 0.0001996 Informative Direct
Molecular Function (MF) protein dimerization activity 0.001354 Informative Inherited
Molecular Function (MF) anion transmembrane transporter activity 0.001611 Informative Inherited
Molecular Function (MF) passive transmembrane transporter activity 0.03952 Informative Inherited
Molecular Function (MF) ligase activity 0.05552 Informative Inherited
Molecular Function (MF) RNA binding 0.8106 Informative Inherited
Molecular Function (MF) modified amino acid binding 0 Highly Informative Direct
Molecular Function (MF) peptide binding 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on a sulfur group of donors 0.000000000000007904 Highly Informative Direct
Molecular Function (MF) drug binding 0.00003445 Highly Informative Direct
Molecular Function (MF) protein homodimerization activity 0.00007362 Highly Informative Direct
Molecular Function (MF) translation factor activity, RNA binding 0.0005266 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-NH group of donors 0.005337 Highly Informative Inherited
Molecular Function (MF) ion channel activity 0.01717 Highly Informative Inherited
Molecular Function (MF) peroxidase activity 1 Highly Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) protein complex 0.9314 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.7977 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) vesicle 0.3773 Moderately Informative Inherited
Cellular Component (CC) extracellular region part 0.6798 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.4233 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 0.01663 Moderately Informative Inherited
Cellular Component (CC) whole membrane 0.05796 Moderately Informative Inherited
Cellular Component (CC) mitochondrial part 0.6521 Moderately Informative Inherited
Cellular Component (CC) outer membrane 0.0000001181 Informative Direct
Cellular Component (CC) extracellular organelle 0.001176 Informative Inherited
Cellular Component (CC) mitochondrial outer membrane 0.0001016 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Isomerases0.6406Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Acting on a sulfur group of donors0.00000003662Moderately InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0.3581Moderately InformativeInherited
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than meth1Moderately InformativeInherited
Enzyme Commission (EC)Glutathione transferase0Highly InformativeDirect
Enzyme Commission (EC)Other intramolecular oxidoreductases0.000000000000002558Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.7625Least InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.4623Moderately InformativeInherited
Disease Ontology (DO)anemia0.01712InformativeInherited
Disease Ontology (DO)congenital hemolytic anemia0.00000594Highly InformativeDirect
Disease Ontology (DO)Barrett's esophagus0.000953Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Neurodevelopmental abnormality0Moderately InformativeDirect
Phenotypic Abnormality (PA)Neurodevelopmental delay0InformativeDirect

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.00000002148Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.006425Least InformativeInherited
Worm Phenotype (WP)organism stress response variant0.000000000001008Moderately InformativeDirect
Worm Phenotype (WP)metal response variant0.002631InformativeInherited
Worm Phenotype (WP)pericellular component morphology variant0.01086InformativeInherited
Worm Phenotype (WP)enzyme activity reduced0Highly InformativeDirect
Worm Phenotype (WP)cadmium hypersensitive0.0000001143Highly InformativeDirect
Worm Phenotype (WP)organism heat response variant0.5797Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant1Least InformativeInherited
Plant ANatomical entity (PAN)portion of vascular tissue0.0004888InformativeDirect
Plant ANatomical entity (PAN)phloem0.0003031Highly InformativeDirect
Plant structure DEvelopment stage (PDE)seed development stage0.0005661InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Isomerases0.5355Moderately InformativeInherited
Enzyme Commission (EC)Ligases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on a sulfur group of donors0.00000002649InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0.3566InformativeInherited
Enzyme Commission (EC)Ligases forming aminoacyl-tRNA and related compounds0.8511InformativeInherited
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than methyl groups1InformativeInherited
Enzyme Commission (EC)With a quinone or similar compound as acceptor0Highly InformativeDirect
Enzyme Commission (EC)Other intramolecular oxidoreductases0.000000000000003382Highly InformativeDirect
Enzyme Commission (EC)Valine--tRNA ligase0.0003946Highly InformativeDirect

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)all other therapeutic products1Moderately InformativeInherited
Drugbank ATC_code (DB)glutathione0InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.5874Least InformativeInherited
Biological processIon transport0.0002688Moderately InformativeDirect
Biological processProtein transport0.0005467Moderately InformativeDirect
Biological processLipid metabolism0.9229Moderately InformativeInherited
Biological processProtein biosynthesis0.000000000000001433InformativeDirect
Biological processStress response0.000000001423InformativeDirect
Biological processFatty acid metabolism0.05849InformativeInherited
Biological processDetoxification0Highly InformativeDirect
Biological processPhenylalanine catabolism0Highly InformativeDirect
Biological processProstaglandin biosynthesis0.00000000000000379Highly InformativeDirect
Biological processNitrate assimilation0.00000000000001423Highly InformativeDirect
Biological processAuxin signaling pathway0.0000000000004226Highly InformativeDirect
Cellular componentCytoplasm0.0000000003177Least InformativeDirect
Cellular componentMitochondrion0.00000002395Moderately InformativeDirect
Cellular componentMitochondrion outer membrane0InformativeDirect
Molecular functionChloride0Highly InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationOxidoreductase1Moderately InformativeInherited
Post-translational modificationIon channel0InformativeDirect
Post-translational modificationElongation factor0Highly InformativeDirect
Post-translational modificationVoltage-gated channel0Highly InformativeDirect
Post-translational modificationEye lens protein0.000000000000002231Highly InformativeDirect
Post-translational modificationPeroxidase0.0000005379Highly InformativeDirect
Post-translational modificationAcetylation0Least InformativeDirect
Post-translational modificationPhosphoprotein0.0000001387Least InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)amino-acid metabolism0.007836Least InformativeInherited
UniPathway (UP)lipid metabolism0.1768Least InformativeInherited
UniPathway (UP)biopolymer metabolism0.4364Least InformativeInherited
UniPathway (UP)amino-acid degradation0.0000000000003418Moderately InformativeDirect
UniPathway (UP)fatty acid metabolism0.001187Moderately InformativeInherited
UniPathway (UP)biopolymer biosynthesis0.02674Moderately InformativeInherited
UniPathway (UP)lipid biosynthesis0.06885Moderately InformativeInherited
UniPathway (UP)protein biosynthesis0.0000332InformativeDirect
UniPathway (UP)fatty acid biosynthesis0.0002211InformativeDirect
UniPathway (UP)L-phenylalanine degradation0Highly InformativeDirect
UniPathway (UP)prostaglandin biosynthesis0.0000000000003107Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR010987 SSF47616 Protein matches
Abstract

In eukaryotes, glutathione S-transferases (GSTs) participate in the detoxification of reactive electrophilic compounds by catalysing their conjugation to glutathione. GST is found as a domain in S-crystallins from squid, and proteins with no known GST activity, such as eukaryotic elongation factors 1-gamma and the HSP26 family of stress-related proteins, which include auxin-regulated proteins in plants and stringent starvation proteins in Escherichia coli. The major lens polypeptide of cephalopods is also a GST [PubMed9074797]. Bacterial GSTs of known function often have a specific, growth-supporting role in biodegradative metabolism: epoxide ring opening and tetrachlorohydroquinone reductive dehalogenation are two examples of the reactions catalysed by these bacterial GSTs. Some regulatory proteins, like the stringent starvation proteins, also belong to the GST family [PubMed9045797]. GST seems to be absent from Archaea in which gamma-glutamylcysteine substitute to glutathione as major thiol.

Glutathione S-transferases form homodimers, but in eukaryotes can also form heterodimers of the A1 and A2 or YC1 and YC2 subunits. The homodimeric enzymes display a conserved structural fold. Each monomer is composed of a distinct N-terminal sub-domain, which adopts the thioredoxin fold, and a C-terminal all-helical sub-domain, which adopts a 4-helical bundle fold. This entry is the C-terminal domain.

Glutaredoxin 2 (Grx2), glutathione-dependent disulphide oxidoreductases, is structurally similar to GSTs, even though they lack any sequence similarity. Grx2 is also composed of N and C terminal subdomains. It is thought that the primary function of Grx2 is to catalyse reversible glutathionylation of proteins with glutathione in cellular redox regulation including the response to oxidative stress. Grx2 is dissimilar to other glutaredoxins apart from containing the conserved active site residues [PubMed14713336].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 52 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a GST C-terminal domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 52 hidden Markov models representing the GST C-terminal domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]