SUPERFAMILY 1.75 HMM library and genome assignments server


GST C-terminal domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   GST C-terminal domain-like [ 47615]
Superfamily:   GST C-terminal domain-like [ 47616] (2)
Families:   Glutathione S-transferase (GST), C-terminal domain [ 47617] (18)
  Arc1p N-terminal domain-like [ 158491]


Superfamily statistics
Genomes (1,846) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 28,165 87,307 104
Proteins 27,906 87,112 104


Functional annotation
General category General
Detailed category Small molecule binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Molecular Function (MF)transferase activity0.012280Least InformativeInherited
Molecular Function (MF)transferase activity, transferring alkyl or aryl (other than methyl) groups5.124e-070InformativeDirect
Molecular Function (MF)glutathione transferase activity5.377e-110Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 5.349e-05 Least Informative Direct
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.02145 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0 Moderately Informative Direct
Biological Process (BP) sulfur compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 1.106e-06 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound catabolic process 0.4491 Moderately Informative Inherited
Biological Process (BP) ion transport 0.7831 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.002441 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.03262 Moderately Informative Inherited
Biological Process (BP) gene expression 0.1773 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular modified amino acid metabolic process 0 Informative Direct
Biological Process (BP) cellular amide metabolic process 0 Informative Direct
Biological Process (BP) secondary metabolic process 0 Informative Direct
Biological Process (BP) translation 1.178e-12 Informative Direct
Biological Process (BP) response to organic cyclic compound 1.243e-07 Informative Direct
Biological Process (BP) response to oxidative stress 9.203e-05 Informative Direct
Biological Process (BP) cellular macromolecular complex assembly 0.4739 Informative Inherited
Biological Process (BP) protein complex assembly 0.7511 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.7546 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) vitamin metabolic process 0.3656 Informative Inherited
Biological Process (BP) anion transport 0.01114 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 1 Informative Inherited
Biological Process (BP) fatty acid metabolic process 0.0107 Informative Inherited
Biological Process (BP) lipid catabolic process 0.0531 Informative Inherited
Biological Process (BP) protein localization to organelle 0.2014 Informative Inherited
Biological Process (BP) mitochondrion organization 0.02764 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.5067 Informative Inherited
Biological Process (BP) protein transport 0.7506 Informative Inherited
Biological Process (BP) ncRNA metabolic process 0.001935 Informative Inherited
Biological Process (BP) xenobiotic metabolic process 0 Highly Informative Direct
Biological Process (BP) glutathione metabolic process 0 Highly Informative Direct
Biological Process (BP) toxin metabolic process 0 Highly Informative Direct
Biological Process (BP) protein localization to mitochondrion 5.778e-07 Highly Informative Direct
Biological Process (BP) benzene-containing compound metabolic process 9.059e-06 Highly Informative Direct
Biological Process (BP) inorganic anion transport 4.621e-05 Highly Informative Direct
Biological Process (BP) mitochondrial transport 0.0001073 Highly Informative Direct
Biological Process (BP) establishment of protein localization to organelle 0.003169 Highly Informative Inherited
Biological Process (BP) response to topologically incorrect protein 0.04132 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.1753 Highly Informative Inherited
Biological Process (BP) lipid modification 0.01158 Highly Informative Inherited
Biological Process (BP) fatty acid catabolic process 0.01397 Highly Informative Inherited
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) anion binding 0.007156 Moderately Informative Inherited
Molecular Function (MF) isomerase activity 0.1159 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity 0.334 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 1 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring alkyl or aryl (other than methyl) groups 0 Informative Direct
Molecular Function (MF) carboxylic acid binding 0 Informative Direct
Molecular Function (MF) sulfur compound binding 0 Informative Direct
Molecular Function (MF) amide binding 0 Informative Direct
Molecular Function (MF) protein dimerization activity 0.006191 Informative Inherited
Molecular Function (MF) anion transmembrane transporter activity 0.001081 Informative Inherited
Molecular Function (MF) RNA binding 0.2543 Informative Inherited
Molecular Function (MF) glutathione transferase activity 0 Highly Informative Direct
Molecular Function (MF) peptide binding 0 Highly Informative Direct
Molecular Function (MF) amino acid binding 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on a sulfur group of donors 0 Highly Informative Direct
Molecular Function (MF) antioxidant activity 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on peroxide as acceptor 1.198e-11 Highly Informative Direct
Molecular Function (MF) translation factor activity, nucleic acid binding 1.178e-05 Highly Informative Direct
Molecular Function (MF) protein homodimerization activity 6.099e-05 Highly Informative Direct
Molecular Function (MF) drug binding 6.874e-05 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0.0006232 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytosol 1.852e-05 Moderately Informative Direct
Cellular Component (CC) organelle envelope 9.086e-05 Moderately Informative Direct
Cellular Component (CC) vesicle 0.03657 Moderately Informative Inherited
Cellular Component (CC) extracellular region part 0.1865 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.09334 Moderately Informative Inherited
Cellular Component (CC) mitochondrial part 0.01872 Moderately Informative Inherited
Cellular Component (CC) extracellular membrane-bounded organelle 0.0001307 Informative Direct
Cellular Component (CC) organelle outer membrane 2.89e-09 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Isomerases0.6406Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Acting on a sulfur group of donors3.662e-08Moderately InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0.3581Moderately InformativeInherited
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than meth1Moderately InformativeInherited
Enzyme Commission (EC)Glutathione transferase0Highly InformativeDirect
Enzyme Commission (EC)Other intramolecular oxidoreductases2.558e-15Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)gastrointestinal system disease0.4223Moderately InformativeInherited
Disease Ontology (DO)esophageal disease0.002028InformativeInherited

Document: DO annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant2.937e-08Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.0003836Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.9124Least InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.2189Moderately InformativeInherited
Worm Phenotype (WP)organism stress response variant3.137e-12InformativeDirect
Worm Phenotype (WP)metal response variant0.0003784InformativeDirect
Worm Phenotype (WP)cell stress response variant0.01053InformativeInherited
Worm Phenotype (WP)enzyme activity reduced0Highly InformativeDirect
Worm Phenotype (WP)oxidative stress response variant0.0002748Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cavitated compound organ0Least InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant1Least InformativeInherited
Plant ANatomical entity (PAN)vascular system0.002619InformativeInherited
Plant ANatomical entity (PAN)phloem0.0002207Highly InformativeDirect
Plant structure DEvelopment stage (PDE)seed development stage0.000565InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Isomerases0.5206Moderately InformativeInherited
Enzyme Commission (EC)Ligases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on a sulfur group of donors2.528e-08InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0.3543InformativeInherited
Enzyme Commission (EC)Ligases forming aminoacyl-tRNA and related compounds0.9397InformativeInherited
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than methyl groups1InformativeInherited
Enzyme Commission (EC)Other intramolecular oxidoreductases1.909e-15Highly InformativeDirect
Enzyme Commission (EC)Valine--tRNA ligase0.0003969Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.4637Least InformativeInherited
Biological processIon transport0.0001524Moderately InformativeDirect
Biological processProtein transport0.0002835Moderately InformativeDirect
Biological processLipid metabolism0.9532Moderately InformativeInherited
Biological processProtein biosynthesis9.352e-16InformativeDirect
Biological processStress response2.495e-10InformativeDirect
Biological processFatty acid metabolism0.04626InformativeInherited
Biological processDetoxification0Highly InformativeDirect
Biological processPhenylalanine catabolism0Highly InformativeDirect
Biological processProstaglandin biosynthesis2.776e-15Highly InformativeDirect
Biological processNitrate assimilation9.138e-15Highly InformativeDirect
Cellular componentCytoplasm7.577e-10Least InformativeDirect
Cellular componentMitochondrion1.936e-08Moderately InformativeDirect
Cellular componentMitochondrion outer membrane0InformativeDirect
Molecular functionChloride0Highly InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationOxidoreductase1Moderately InformativeInherited
Post-translational modificationIon channel0InformativeDirect
Post-translational modificationElongation factor0Highly InformativeDirect
Post-translational modificationVoltage-gated channel0Highly InformativeDirect
Post-translational modificationEye lens protein1.762e-15Highly InformativeDirect
Post-translational modificationPeroxidase3.846e-07Highly InformativeDirect
Post-translational modificationAcetylation0Least InformativeDirect
Post-translational modificationPhosphoprotein4.798e-06Least InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)amino-acid metabolism0.008114Least InformativeInherited
UniPathway (UP)lipid metabolism0.1738Least InformativeInherited
UniPathway (UP)biopolymer metabolism0.4248Least InformativeInherited
UniPathway (UP)amino-acid degradation3.552e-13Moderately InformativeDirect
UniPathway (UP)fatty acid metabolism0.00108Moderately InformativeInherited
UniPathway (UP)biopolymer biosynthesis0.02596Moderately InformativeInherited
UniPathway (UP)lipid biosynthesis0.06807Moderately InformativeInherited
UniPathway (UP)protein biosynthesis3.35e-05InformativeDirect
UniPathway (UP)fatty acid biosynthesis0.0001953InformativeDirect
UniPathway (UP)L-phenylalanine degradation0Highly InformativeDirect
UniPathway (UP)prostaglandin biosynthesis3.18e-13Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR010987 SSF47616 Protein matches
Abstract

In eukaryotes, glutathione S-transferases (GSTs) participate in the detoxification of reactive electrophilic compounds by catalysing their conjugation to glutathione. GST is found as a domain in S-crystallins from squid, and proteins with no known GST activity, such as eukaryotic elongation factors 1-gamma and the HSP26 family of stress-related proteins, which include auxin-regulated proteins in plants and stringent starvation proteins in Escherichia coli. The major lens polypeptide of cephalopods is also a GST [PubMed9074797]. Bacterial GSTs of known function often have a specific, growth-supporting role in biodegradative metabolism: epoxide ring opening and tetrachlorohydroquinone reductive dehalogenation are two examples of the reactions catalysed by these bacterial GSTs. Some regulatory proteins, like the stringent starvation proteins, also belong to the GST family [PubMed9045797]. GST seems to be absent from Archaea in which gamma-glutamylcysteine substitute to glutathione as major thiol.

Glutathione S-transferases form homodimers, but in eukaryotes can also form heterodimers of the A1 and A2 or YC1 and YC2 subunits. The homodimeric enzymes display a conserved structural fold. Each monomer is composed of a distinct N-terminal sub-domain, which adopts the thioredoxin fold, and a C-terminal all-helical sub-domain, which adopts a 4-helical bundle fold. This entry is the C-terminal domain.

Glutaredoxin 2 (Grx2), glutathione-dependent disulphide oxidoreductases, is structurally similar to GSTs, even though they lack any sequence similarity. Grx2 is also composed of N and C terminal subdomains. It is thought that the primary function of Grx2 is to catalyse reversible glutathionylation of proteins with glutathione in cellular redox regulation including the response to oxidative stress. Grx2 is dissimilar to other glutaredoxins apart from containing the conserved active site residues [PubMed14713336].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 52 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a GST C-terminal domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 52 hidden Markov models representing the GST C-terminal domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]