SUPERFAMILY 1.75 HMM library and genome assignments server

GST C-terminal domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   GST C-terminal domain-like [ 47615]
Superfamily:   GST C-terminal domain-like [ 47616] (2)
Families:   Glutathione S-transferase (GST), C-terminal domain [ 47617] (18)
  Arc1p N-terminal domain-like [ 158491]


Superfamily statistics
Genomes (1,847) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 28,227 87,307 104
Proteins 27,967 87,112 104


Functional annotation
General category General
Detailed category Small molecule binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Molecular Function (MF)transferase activity0.021540Least InformativeInherited
Molecular Function (MF)transferase activity, transferring alkyl or aryl (other than methyl) groups0.00000083590InformativeDirect
Molecular Function (MF)glutathione transferase activity0.000000000077660Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism cellular process 0.0002601 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.00007146 Least Informative Direct
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.005952 Least Informative Inherited
Biological Process (BP) positive regulation of biological process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular amino acid metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0.0000008779 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.0002281 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) defense response 0.1878 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) immune system process 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 0.007929 Moderately Informative Inherited
Biological Process (BP) ion transport 0.7185 Moderately Informative Inherited
Biological Process (BP) oxidation-reduction process 0.0863 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) gene expression 0.2721 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.04018 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) peptide metabolic process 0 Informative Direct
Biological Process (BP) cellular modified amino acid metabolic process 0 Informative Direct
Biological Process (BP) secondary metabolic process 0 Informative Direct
Biological Process (BP) response to organic cyclic compound 0.000002154 Informative Direct
Biological Process (BP) response to oxidative stress 0.00001036 Informative Direct
Biological Process (BP) ion transmembrane transport 0.2844 Informative Inherited
Biological Process (BP) protein localization to organelle 0.2212 Informative Inherited
Biological Process (BP) positive regulation of intracellular signal transduction 0.8581 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 0.5433 Informative Inherited
Biological Process (BP) ncRNA metabolic process 0.002185 Informative Inherited
Biological Process (BP) immune response 0.233 Informative Inherited
Biological Process (BP) response to cytokine 1 Informative Inherited
Biological Process (BP) vitamin metabolic process 0.3371 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 1 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 1 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.8003 Informative Inherited
Biological Process (BP) anion transport 0.002839 Informative Inherited
Biological Process (BP) fatty acid metabolic process 0.01289 Informative Inherited
Biological Process (BP) lipid catabolic process 0.219 Informative Inherited
Biological Process (BP) single-organism intracellular transport 1 Informative Inherited
Biological Process (BP) mitochondrion organization 0.03015 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.6057 Informative Inherited
Biological Process (BP) single-organism cellular localization 0.7629 Informative Inherited
Biological Process (BP) protein transport 0.7804 Informative Inherited
Biological Process (BP) xenobiotic metabolic process 0 Highly Informative Direct
Biological Process (BP) secondary metabolite catabolic process 0 Highly Informative Direct
Biological Process (BP) toxin metabolic process 0 Highly Informative Direct
Biological Process (BP) glutathione metabolic process 0 Highly Informative Direct
Biological Process (BP) protein localization to mitochondrion 0.00000066 Highly Informative Direct
Biological Process (BP) benzene-containing compound metabolic process 0.000009543 Highly Informative Direct
Biological Process (BP) inorganic anion transport 0.00002309 Highly Informative Direct
Biological Process (BP) anion transmembrane transport 0.0000593 Highly Informative Direct
Biological Process (BP) mitochondrial transport 0.0001214 Highly Informative Direct
Biological Process (BP) response to topologically incorrect protein 0.05792 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.2207 Highly Informative Inherited
Biological Process (BP) innate immune response 0.002893 Highly Informative Inherited
Biological Process (BP) lipid modification 0.01319 Highly Informative Inherited
Biological Process (BP) fatty acid catabolic process 0.01333 Highly Informative Inherited
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) small molecule binding 0.0000001783 Moderately Informative Direct
Molecular Function (MF) anion binding 0.002466 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity 0.3681 Moderately Informative Inherited
Molecular Function (MF) isomerase activity 0.128 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 1 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring alkyl or aryl (other than methyl) groups 0 Informative Direct
Molecular Function (MF) sulfur compound binding 0 Informative Direct
Molecular Function (MF) carboxylic acid binding 0 Informative Direct
Molecular Function (MF) amide binding 0 Informative Direct
Molecular Function (MF) protein dimerization activity 0.0007766 Informative Direct
Molecular Function (MF) ligase activity 0.05157 Informative Inherited
Molecular Function (MF) anion transmembrane transporter activity 0.001325 Informative Inherited
Molecular Function (MF) RNA binding 0.5442 Informative Inherited
Molecular Function (MF) glutathione transferase activity 0 Highly Informative Direct
Molecular Function (MF) amino acid binding 0 Highly Informative Direct
Molecular Function (MF) peptide binding 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on a sulfur group of donors 0 Highly Informative Direct
Molecular Function (MF) antioxidant activity 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on peroxide as acceptor 0.00000000003324 Highly Informative Direct
Molecular Function (MF) inorganic anion transmembrane transporter activity 0.000001248 Highly Informative Direct
Molecular Function (MF) protein homodimerization activity 0.000002697 Highly Informative Direct
Molecular Function (MF) translation factor activity, nucleic acid binding 0.0000127 Highly Informative Direct
Molecular Function (MF) drug binding 0.00008263 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0.0004211 Least Informative Direct
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytosol 0.0000572 Moderately Informative Direct
Cellular Component (CC) organelle envelope 0.00009965 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.2059 Moderately Informative Inherited
Cellular Component (CC) vesicle 0.04614 Moderately Informative Inherited
Cellular Component (CC) mitochondrial part 0.02063 Moderately Informative Inherited
Cellular Component (CC) bounding membrane of organelle 0.8281 Moderately Informative Inherited
Cellular Component (CC) extracellular membrane-bounded organelle 0.0001918 Informative Direct
Cellular Component (CC) organelle outer membrane 0.000000004382 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Isomerases0.6406Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Acting on a sulfur group of donors0.00000003662Moderately InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0.3581Moderately InformativeInherited
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than meth1Moderately InformativeInherited
Enzyme Commission (EC)Glutathione transferase0Highly InformativeDirect
Enzyme Commission (EC)Other intramolecular oxidoreductases0.000000000000002558Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)esophageal disease0.002089InformativeInherited

Document: DO annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.00000002937Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.0003836Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.9124Least InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.2189Moderately InformativeInherited
Worm Phenotype (WP)organism stress response variant0.000000000003137InformativeDirect
Worm Phenotype (WP)metal response variant0.0003784InformativeDirect
Worm Phenotype (WP)cell stress response variant0.01053InformativeInherited
Worm Phenotype (WP)enzyme activity reduced0Highly InformativeDirect
Worm Phenotype (WP)oxidative stress response variant0.0002748Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cavitated compound organ0Least InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant1Least InformativeInherited
Plant ANatomical entity (PAN)vascular system0.002619InformativeInherited
Plant ANatomical entity (PAN)phloem0.0002207Highly InformativeDirect
Plant structure DEvelopment stage (PDE)seed development stage0.000565InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Isomerases0.5181Moderately InformativeInherited
Enzyme Commission (EC)Ligases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on a sulfur group of donors0.00000002572InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0.3526InformativeInherited
Enzyme Commission (EC)Ligases forming aminoacyl-tRNA and related compounds0.9358InformativeInherited
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than methyl groups1InformativeInherited
Enzyme Commission (EC)Other intramolecular oxidoreductases0.00000000000000168Highly InformativeDirect
Enzyme Commission (EC)Valine--tRNA ligase0.000393Highly InformativeDirect

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)all other therapeutic products1Moderately InformativeInherited
Drugbank ATC_code (DB)glutathione0InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.4642Least InformativeInherited
Biological processIon transport0.0001539Moderately InformativeDirect
Biological processProtein transport0.0002839Moderately InformativeDirect
Biological processLipid metabolism0.9521Moderately InformativeInherited
Biological processProtein biosynthesis9.345e-16InformativeDirect
Biological processStress response0.0000000002721InformativeDirect
Biological processFatty acid metabolism0.0459InformativeInherited
Biological processDetoxification0Highly InformativeDirect
Biological processPhenylalanine catabolism0Highly InformativeDirect
Biological processProstaglandin biosynthesis0.000000000000002773Highly InformativeDirect
Biological processNitrate assimilation0.00000000000001002Highly InformativeDirect
Biological processAuxin signaling pathway0.000000000000219Highly InformativeDirect
Cellular componentCytoplasm0.000000000226Least InformativeDirect
Cellular componentMitochondrion0.000000006253Moderately InformativeDirect
Cellular componentMitochondrion outer membrane0InformativeDirect
Molecular functionChloride0Highly InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationOxidoreductase1Moderately InformativeInherited
Post-translational modificationIon channel0InformativeDirect
Post-translational modificationElongation factor0Highly InformativeDirect
Post-translational modificationVoltage-gated channel0Highly InformativeDirect
Post-translational modificationEye lens protein0.000000000000001766Highly InformativeDirect
Post-translational modificationPeroxidase0.0000003809Highly InformativeDirect
Post-translational modificationAcetylation0Least InformativeDirect
Post-translational modificationPhosphoprotein0.00000501Least InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)amino-acid metabolism0.008095Least InformativeInherited
UniPathway (UP)lipid metabolism0.1734Least InformativeInherited
UniPathway (UP)biopolymer metabolism0.4247Least InformativeInherited
UniPathway (UP)amino-acid degradation0.0000000000003587Moderately InformativeDirect
UniPathway (UP)fatty acid metabolism0.001078Moderately InformativeInherited
UniPathway (UP)biopolymer biosynthesis0.0259Moderately InformativeInherited
UniPathway (UP)lipid biosynthesis0.06793Moderately InformativeInherited
UniPathway (UP)protein biosynthesis0.00003347InformativeDirect
UniPathway (UP)fatty acid biosynthesis0.0001951InformativeDirect
UniPathway (UP)L-phenylalanine degradation0Highly InformativeDirect
UniPathway (UP)prostaglandin biosynthesis0.0000000000003175Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR010987 SSF47616 Protein matches
Abstract

In eukaryotes, glutathione S-transferases (GSTs) participate in the detoxification of reactive electrophilic compounds by catalysing their conjugation to glutathione. GST is found as a domain in S-crystallins from squid, and proteins with no known GST activity, such as eukaryotic elongation factors 1-gamma and the HSP26 family of stress-related proteins, which include auxin-regulated proteins in plants and stringent starvation proteins in Escherichia coli. The major lens polypeptide of cephalopods is also a GST [PubMed9074797]. Bacterial GSTs of known function often have a specific, growth-supporting role in biodegradative metabolism: epoxide ring opening and tetrachlorohydroquinone reductive dehalogenation are two examples of the reactions catalysed by these bacterial GSTs. Some regulatory proteins, like the stringent starvation proteins, also belong to the GST family [PubMed9045797]. GST seems to be absent from Archaea in which gamma-glutamylcysteine substitute to glutathione as major thiol.

Glutathione S-transferases form homodimers, but in eukaryotes can also form heterodimers of the A1 and A2 or YC1 and YC2 subunits. The homodimeric enzymes display a conserved structural fold. Each monomer is composed of a distinct N-terminal sub-domain, which adopts the thioredoxin fold, and a C-terminal all-helical sub-domain, which adopts a 4-helical bundle fold. This entry is the C-terminal domain.

Glutaredoxin 2 (Grx2), glutathione-dependent disulphide oxidoreductases, is structurally similar to GSTs, even though they lack any sequence similarity. Grx2 is also composed of N and C terminal subdomains. It is thought that the primary function of Grx2 is to catalyse reversible glutathionylation of proteins with glutathione in cellular redox regulation including the response to oxidative stress. Grx2 is dissimilar to other glutaredoxins apart from containing the conserved active site residues [PubMed14713336].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 52 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a GST C-terminal domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 52 hidden Markov models representing the GST C-terminal domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]