SUPERFAMILY 1.75 HMM library and genome assignments server

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STAT superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   STAT-like [ 47654] (6)
Superfamily:   STAT [ 47655]
Families:   STAT [ 47656] (3)

Superfamily statistics
Genomes (166) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 718 2,193 3
Proteins 708 2,168 3

Functional annotation
General category Regulation
Detailed category DNA-binding

Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.09213Least InformativeInherited
Disease Ontology (DO)lower respiratory tract disease0.00008071Moderately InformativeDirect
Disease Ontology (DO)urinary system disease0.001681Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.00267Moderately InformativeInherited
Disease Ontology (DO)hematologic cancer0.0171Moderately InformativeInherited
Disease Ontology (DO)disease by infectious agent0.01793Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.7675Moderately InformativeInherited
Disease Ontology (DO)inflammatory bowel disease0.000001177InformativeDirect
Disease Ontology (DO)head and neck carcinoma0.0000191InformativeDirect
Disease Ontology (DO)asthma0.0001194InformativeDirect
Disease Ontology (DO)nephritis0.0003477InformativeDirect
Disease Ontology (DO)myeloid leukemia0.1327InformativeInherited
Disease Ontology (DO)viral infectious disease0.2685InformativeInherited
Disease Ontology (DO)mumps0.000000003951Highly InformativeDirect
Disease Ontology (DO)colitis0.0000001594Highly InformativeDirect
Disease Ontology (DO)Sjogren's syndrome0.00001043Highly InformativeDirect
Disease Ontology (DO)chronic leukemia0.00001099Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of immune system physiology0.07714Moderately InformativeInherited
Phenotypic Abnormality (PA)Autoimmunity0.0001335Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)hematopoietic system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect
Mammalian Phenotype (MP)abnormal homeostasis0.02171Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.07389Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body region phenotype0.1054Least InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal leukocyte physiology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal blood cell morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal protein level0.00001724Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal gland morphology0.0006682Moderately InformativeDirect
Mammalian Phenotype (MP)liver/biliary system phenotype0.0008923Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cell death0.001834Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.005089Moderately InformativeInherited
Mammalian Phenotype (MP)neoplasm0.02365Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.03098Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.03707Moderately InformativeInherited
Mammalian Phenotype (MP)reproductive system phenotype0.03744Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal postnatal growth/weight/body size0.04053Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.04572Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal body composition0.1735Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal myeloid cell morphology0.4352Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.7146Moderately InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to infection0.8287Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin level0.000000004266InformativeDirect
Mammalian Phenotype (MP)abnormal circulating cytokine level0.000000008389InformativeDirect
Mammalian Phenotype (MP)abnormal interleukin secretion0.0000001329InformativeDirect
Mammalian Phenotype (MP)abnormal mammary gland morphology0.0000003329InformativeDirect
Mammalian Phenotype (MP)abnormal B lymphocyte antigen presentation0.0000003822InformativeDirect
Mammalian Phenotype (MP)abnormal liver physiology0.000003434InformativeDirect
Mammalian Phenotype (MP)abnormal adaptive thermogenesis0.0000635InformativeDirect
Mammalian Phenotype (MP)increased apoptosis0.0001341InformativeDirect
Mammalian Phenotype (MP)increased susceptibility to infection0.0002424InformativeDirect
Mammalian Phenotype (MP)abnormal circulating leptin level0.0003292InformativeDirect
Mammalian Phenotype (MP)decreased cell proliferation0.0003418InformativeDirect
Mammalian Phenotype (MP)altered tumor pathology0.0008784InformativeDirect
Mammalian Phenotype (MP)increased body weight0.001125InformativeInherited
Mammalian Phenotype (MP)abnormal female reproductive gland morphology0.001149InformativeInherited
Mammalian Phenotype (MP)abnormal internal female genitalia morphology0.002381InformativeInherited
Mammalian Phenotype (MP)abnormal adipose tissue amount0.009383InformativeInherited
Mammalian Phenotype (MP)abnormal gland physiology0.009859InformativeInherited
Mammalian Phenotype (MP)abnormal lean body mass0.01064InformativeInherited
Mammalian Phenotype (MP)abnormal T cell differentiation0.01335InformativeInherited
Mammalian Phenotype (MP)abnormal consumption behavior0.04317InformativeInherited
Mammalian Phenotype (MP)abnormal glucose homeostasis0.05126InformativeInherited
Mammalian Phenotype (MP)abnormal pancreas morphology0.05152InformativeInherited
Mammalian Phenotype (MP)abnormal interferon level0.05161InformativeInherited
Mammalian Phenotype (MP)abnormal triglyceride level0.1353InformativeInherited
Mammalian Phenotype (MP)abnormal T cell physiology0.145InformativeInherited
Mammalian Phenotype (MP)abnormal circulating lipid level0.1656InformativeInherited
Mammalian Phenotype (MP)abnormal interferon secretion0.2328InformativeInherited
Mammalian Phenotype (MP)abnormal effector T cell morphology0.2465InformativeInherited
Mammalian Phenotype (MP)abnormal natural killer cell mediated cytotoxicity0.3235InformativeInherited
Mammalian Phenotype (MP)abnormal alpha-beta T cell morphology0.3291InformativeInherited
Mammalian Phenotype (MP)abnormal erythroid lineage cell morphology0.3707InformativeInherited
Mammalian Phenotype (MP)abnormal T cell activation0.00000002746Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mammary gland epithelium physiology0.0000001538Highly InformativeDirect
Mammalian Phenotype (MP)abnormal CD4-positive, alpha beta T cell morphology0.000000156Highly InformativeDirect
Mammalian Phenotype (MP)abnormal level of surface class II molecules0.0000001813Highly InformativeDirect
Mammalian Phenotype (MP)increased interferon-gamma secretion0.000001083Highly InformativeDirect
Mammalian Phenotype (MP)impaired adaptive thermogenesis0.000001601Highly InformativeDirect
Mammalian Phenotype (MP)increased percent body fat/body weight0.000005301Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating insulin-like growth factor I level0.000005965Highly InformativeDirect
Mammalian Phenotype (MP)decreased mean corpuscular hemoglobin0.000007512Highly InformativeDirect
Mammalian Phenotype (MP)obese0.00002113Highly InformativeDirect
Mammalian Phenotype (MP)abnormal corpus luteum morphology0.00003129Highly InformativeDirect
Mammalian Phenotype (MP)increased lean body mass0.0000788Highly InformativeDirect
Mammalian Phenotype (MP)increased total body fat amount0.0001044Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating triglyceride level0.0001347Highly InformativeDirect
Mammalian Phenotype (MP)abnormal endocrine pancreas secretion0.0001611Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pancreatic beta cell physiology0.0002342Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating insulin level0.0002864Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pancreatic islet morphology0.0004467Highly InformativeDirect
Mammalian Phenotype (MP)decreased lean body mass0.0005283Highly InformativeDirect
Mammalian Phenotype (MP)abnormal fat pad morphology0.0006714Highly InformativeDirect
Mammalian Phenotype (MP)abnormal food intake0.002522Highly InformativeInherited
Mammalian Phenotype (MP)abnormal liver size0.0843Highly InformativeInherited

Document: MP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0Least InformativeDirect
Zebrafish Anatomy (ZA)portion of organism substance0Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

InterPro annotation
Cross references IPR015988 SSF47655 Protein matches

This entry represents a domain consisting of four long helices that forms a bundle with a left-handed twist (coiled coil), in a right-handed superhelix.

InterPro database

PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Browse and view proteins in genomes which have different domain combinations including a STAT domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the STAT superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]