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STAT superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   STAT-like [ 47654] (6)
Superfamily:   STAT [ 47655]
Families:   STAT [ 47656] (3)


Superfamily statistics
Genomes (161) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 702 960 3
Proteins 692 949 3


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) cellular nitrogen compound metabolic process 0.5645 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.001372 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.879 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.08347 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.8727 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.3799 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) cell communication 0 Moderately Informative Direct
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) signaling 0 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.000000000009599 Moderately Informative Direct
Biological Process (BP) cellular developmental process 0.00000000007512 Moderately Informative Direct
Biological Process (BP) regulation of biosynthetic process 0.000000004339 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0.000000008379 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.00000001091 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.0000000146 Moderately Informative Direct
Biological Process (BP) regulation of cellular metabolic process 0.00000001658 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.00000002593 Moderately Informative Direct
Biological Process (BP) reproduction 0.00000009522 Moderately Informative Direct
Biological Process (BP) regulation of nitrogen compound metabolic process 0.000008346 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.000009738 Moderately Informative Direct
Biological Process (BP) system development 0.0002466 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 0.0005057 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0.0009406 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.003225 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.01236 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.138 Moderately Informative Inherited
Biological Process (BP) response to stress 0.1511 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.1688 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.3247 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.9651 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.1309 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing compound biosynthetic process 0.006006 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.08126 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.002134 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.002595 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.1407 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.01218 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.00766 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.6334 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.09208 Moderately Informative Inherited
Biological Process (BP) gene expression 0.1504 Moderately Informative Inherited
Biological Process (BP) regulation of transcription, DNA-templated 0 Informative Direct
Biological Process (BP) response to cytokine 0 Informative Direct
Biological Process (BP) regulation of apoptotic process 0 Informative Direct
Biological Process (BP) regulation of cell proliferation 0 Informative Direct
Biological Process (BP) intracellular signal transduction 0 Informative Direct
Biological Process (BP) regulation of cell differentiation 0.0000000000002429 Informative Direct
Biological Process (BP) regulation of hydrolase activity 0.000000000003589 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.00000000005588 Informative Direct
Biological Process (BP) immune response 0.0000000001156 Informative Direct
Biological Process (BP) cellular response to hormone stimulus 0.0000000004204 Informative Direct
Biological Process (BP) positive regulation of gene expression 0.000000005037 Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.00000001798 Informative Direct
Biological Process (BP) response to nitrogen compound 0.00000002374 Informative Direct
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0.00000003062 Informative Direct
Biological Process (BP) cell death 0.00000005017 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0.0000002007 Informative Direct
Biological Process (BP) cell surface receptor signaling pathway 0.000004415 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.00001706 Informative Direct
Biological Process (BP) lipid localization 0.00002176 Informative Direct
Biological Process (BP) nucleocytoplasmic transport 0.00003923 Informative Direct
Biological Process (BP) regulation of proteolysis 0.00004591 Informative Direct
Biological Process (BP) behavior 0.00006496 Informative Direct
Biological Process (BP) cellular ketone metabolic process 0.0001027 Informative Direct
Biological Process (BP) transcription, DNA-templated 0.000139 Informative Direct
Biological Process (BP) generation of neurons 0.000146 Informative Direct
Biological Process (BP) protein targeting 0.0002225 Informative Direct
Biological Process (BP) negative regulation of signaling 0.0003957 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.0004644 Informative Direct
Biological Process (BP) positive regulation of cell death 0.0004645 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.0006445 Informative Direct
Biological Process (BP) regulation of growth 0.0007251 Informative Direct
Biological Process (BP) protein localization to organelle 0.0007948 Informative Direct
Biological Process (BP) response to organic cyclic compound 0.04541 Informative Inherited
Biological Process (BP) regulation of defense response 0.001664 Informative Inherited
Biological Process (BP) central nervous system development 1 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.1066 Informative Inherited
Biological Process (BP) regulation of cell cycle 0.009623 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.0041 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.0261 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.005272 Informative Inherited
Biological Process (BP) response to oxidative stress 0.269 Informative Inherited
Biological Process (BP) response to inorganic substance 1 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.1905 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.1999 Informative Inherited
Biological Process (BP) secretion 0.004801 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.02701 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.1284 Informative Inherited
Biological Process (BP) single organism reproductive process 0.2396 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.01059 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.3924 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.06154 Informative Inherited
Biological Process (BP) system process 0.001391 Informative Inherited
Biological Process (BP) multi-organism reproductive process 0.002224 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.3067 Informative Inherited
Biological Process (BP) embryo development 1 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 0.3655 Informative Inherited
Biological Process (BP) single-organism intracellular transport 0.03751 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.3947 Informative Inherited
Biological Process (BP) reproductive system development 0.4253 Informative Inherited
Biological Process (BP) cytokine-mediated signaling pathway 0 Highly Informative Direct
Biological Process (BP) response to nutrient levels 0 Highly Informative Direct
Biological Process (BP) hemopoiesis 0 Highly Informative Direct
Biological Process (BP) lymphocyte activation 0.000000000000003692 Highly Informative Direct
Biological Process (BP) apoptotic process 0.00000000000001068 Highly Informative Direct
Biological Process (BP) cell proliferation 0.00000000000001746 Highly Informative Direct
Biological Process (BP) response to organophosphorus 0.0000000000001404 Highly Informative Direct
Biological Process (BP) regulation of smooth muscle cell proliferation 0.0000000000007904 Highly Informative Direct
Biological Process (BP) response to purine-containing compound 0.000000000009106 Highly Informative Direct
Biological Process (BP) positive regulation of proteolysis 0.00000000001484 Highly Informative Direct
Biological Process (BP) positive regulation of mitotic cell cycle 0.0000000000581 Highly Informative Direct
Biological Process (BP) ovulation cycle process 0.0000000001139 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.0000000001566 Highly Informative Direct
Biological Process (BP) positive regulation of lymphocyte activation 0.0000000001662 Highly Informative Direct
Biological Process (BP) innate immune response 0.0000000007408 Highly Informative Direct
Biological Process (BP) response to peptide hormone 0.0000000009868 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular signal transduction 0.0000000462 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-templated 0.0000001289 Highly Informative Direct
Biological Process (BP) negative regulation of homeostatic process 0.0000002498 Highly Informative Direct
Biological Process (BP) cellular response to organonitrogen compound 0.0000006381 Highly Informative Direct
Biological Process (BP) response to hydrogen peroxide 0.0000009234 Highly Informative Direct
Biological Process (BP) protein targeting to nucleus 0.000001272 Highly Informative Direct
Biological Process (BP) cellular hormone metabolic process 0.000001272 Highly Informative Direct
Biological Process (BP) single-organism nuclear import 0.000001379 Highly Informative Direct
Biological Process (BP) sensory organ morphogenesis 0.000003026 Highly Informative Direct
Biological Process (BP) gastrulation 0.000007341 Highly Informative Direct
Biological Process (BP) sex differentiation 0.00001038 Highly Informative Direct
Biological Process (BP) steroid metabolic process 0.00001188 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 0.00003188 Highly Informative Direct
Biological Process (BP) regulation of inflammatory response 0.00004676 Highly Informative Direct
Biological Process (BP) positive regulation of response to external stimulus 0.00006731 Highly Informative Direct
Biological Process (BP) multicellular organismal homeostasis 0.0001025 Highly Informative Direct
Biological Process (BP) hormone-mediated signaling pathway 0.0003146 Highly Informative Direct
Biological Process (BP) multi-multicellular organism process 0.0003252 Highly Informative Direct
Biological Process (BP) protein import 0.0003688 Highly Informative Direct
Biological Process (BP) negative regulation of immune system process 0.0005639 Highly Informative Direct
Biological Process (BP) positive regulation of cell adhesion 0.01705 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 1 Highly Informative Inherited
Biological Process (BP) gliogenesis 0.001248 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 0.02368 Highly Informative Inherited
Biological Process (BP) positive regulation of apoptotic process 0.0365 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.005064 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 0.06779 Highly Informative Inherited
Biological Process (BP) regulation of lymphocyte proliferation 0.012 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.02278 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.007329 Highly Informative Inherited
Biological Process (BP) positive regulation of leukocyte proliferation 0.1508 Highly Informative Inherited
Biological Process (BP) regulation of cysteine-type endopeptidase activity 0.1113 Highly Informative Inherited
Biological Process (BP) regulation of epithelial cell proliferation 0.01267 Highly Informative Inherited
Molecular Function (MF) binding 0.000000001439 Least Informative Direct
Molecular Function (MF) nucleic acid binding 0 Moderately Informative Direct
Molecular Function (MF) protein binding 0.4274 Moderately Informative Inherited
Molecular Function (MF) DNA binding 0 Informative Direct
Molecular Function (MF) transcription factor activity, sequence-specific DNA binding 0 Informative Direct
Molecular Function (MF) enzyme binding 0.0000000000304 Informative Direct
Molecular Function (MF) protein dimerization activity 0.0000000008276 Informative Direct
Molecular Function (MF) receptor binding 0.05331 Informative Inherited
Molecular Function (MF) macromolecular complex binding 0.003808 Informative Inherited
Molecular Function (MF) protein phosphatase binding 0.00000000004601 Highly Informative Direct
Molecular Function (MF) chromatin binding 0.000000005335 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0.0000003279 Highly Informative Direct
Molecular Function (MF) cytokine receptor binding 0.00008974 Highly Informative Direct
Molecular Function (MF) G-protein coupled receptor binding 0.000124 Highly Informative Direct
Molecular Function (MF) transcription regulatory region DNA binding 0.0007883 Highly Informative Direct
Molecular Function (MF) kinase binding 0.001384 Highly Informative Inherited
Molecular Function (MF) sequence-specific DNA binding 0.3728 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.5397 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.6914 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.00002906 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.05466 Moderately Informative Inherited
Cellular Component (CC) cell projection 0.23 Moderately Informative Inherited
Cellular Component (CC) neuron projection 0.0006088 Informative Direct
Cellular Component (CC) nucleolus 0.00000004082 Highly Informative Direct
Cellular Component (CC) dendrite 0.000002251 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.09117Least InformativeInherited
Disease Ontology (DO)organ system cancer0.09172Least InformativeInherited
Disease Ontology (DO)lower respiratory tract disease0.00007882Moderately InformativeDirect
Disease Ontology (DO)urinary system disease0.001664Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.002601Moderately InformativeInherited
Disease Ontology (DO)hematologic cancer0.01691Moderately InformativeInherited
Disease Ontology (DO)disease by infectious agent0.01724Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.7634Moderately InformativeInherited
Disease Ontology (DO)inflammatory bowel disease0.000001079InformativeDirect
Disease Ontology (DO)head and neck carcinoma0.00001876InformativeDirect
Disease Ontology (DO)asthma0.0001183InformativeDirect
Disease Ontology (DO)nephritis0.0003394InformativeDirect
Disease Ontology (DO)myeloid leukemia0.1327InformativeInherited
Disease Ontology (DO)viral infectious disease0.2667InformativeInherited
Disease Ontology (DO)mumps0.000000004049Highly InformativeDirect
Disease Ontology (DO)colitis0.0000001545Highly InformativeDirect
Disease Ontology (DO)Sjogren's syndrome0.00001014Highly InformativeDirect
Disease Ontology (DO)chronic leukemia0.00001111Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the immune system0.04485Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the face0.4039Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the oral cavity0.1318Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of oral mucosa0.0004558InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)hematopoietic system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect
Mammalian Phenotype (MP)abnormal homeostasis0.01868Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.07846Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body region phenotype0.1066Least InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal leukocyte physiology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal blood cell morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal protein level0.00001204Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal gland morphology0.0006656Moderately InformativeDirect
Mammalian Phenotype (MP)liver/biliary system phenotype0.0009544Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cell death0.001996Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.004935Moderately InformativeInherited
Mammalian Phenotype (MP)neoplasm0.02479Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal body size0.026Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.03013Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.03639Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.04415Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.3376Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.7148Moderately InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to infection0.8286Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin level0.000000004824InformativeDirect
Mammalian Phenotype (MP)abnormal circulating cytokine level0.000000009454InformativeDirect
Mammalian Phenotype (MP)abnormal interleukin secretion0.0000001466InformativeDirect
Mammalian Phenotype (MP)abnormal mammary gland morphology0.0000003591InformativeDirect
Mammalian Phenotype (MP)abnormal B lymphocyte antigen presentation0.0000004059InformativeDirect
Mammalian Phenotype (MP)abnormal liver physiology0.000003739InformativeDirect
Mammalian Phenotype (MP)abnormal adaptive thermogenesis0.00007346InformativeDirect
Mammalian Phenotype (MP)increased apoptosis0.0001466InformativeDirect
Mammalian Phenotype (MP)increased susceptibility to infection0.0002604InformativeDirect
Mammalian Phenotype (MP)abnormal circulating leptin level0.0003417InformativeDirect
Mammalian Phenotype (MP)decreased cell proliferation0.0003646InformativeDirect
Mammalian Phenotype (MP)altered tumor pathology0.0009191InformativeDirect
Mammalian Phenotype (MP)increased body weight0.001165InformativeInherited
Mammalian Phenotype (MP)abnormal female reproductive gland morphology0.001217InformativeInherited
Mammalian Phenotype (MP)abnormal circulating triglyceride level0.00127InformativeInherited
Mammalian Phenotype (MP)abnormal internal female genitalia morphology0.002349InformativeInherited
Mammalian Phenotype (MP)abnormal adipose tissue amount0.008497InformativeInherited
Mammalian Phenotype (MP)abnormal gland physiology0.01034InformativeInherited
Mammalian Phenotype (MP)abnormal glucose homeostasis0.04107InformativeInherited
Mammalian Phenotype (MP)abnormal consumption behavior0.0478InformativeInherited
Mammalian Phenotype (MP)abnormal interferon level0.05121InformativeInherited
Mammalian Phenotype (MP)abnormal pancreas morphology0.05226InformativeInherited
Mammalian Phenotype (MP)abnormal triglyceride level0.1354InformativeInherited
Mammalian Phenotype (MP)abnormal T cell physiology0.147InformativeInherited
Mammalian Phenotype (MP)abnormal interferon secretion0.2329InformativeInherited
Mammalian Phenotype (MP)abnormal effector T cell morphology0.2518InformativeInherited
Mammalian Phenotype (MP)abnormal natural killer cell mediated cytotoxicity0.3168InformativeInherited
Mammalian Phenotype (MP)abnormal alpha-beta T cell morphology0.3384InformativeInherited
Mammalian Phenotype (MP)abnormal T cell activation0.00000003082Highly InformativeDirect
Mammalian Phenotype (MP)abnormal CD4-positive, alpha beta T cell morphology0.0000001426Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mammary gland epithelium physiology0.0000001622Highly InformativeDirect
Mammalian Phenotype (MP)abnormal level of surface class II molecules0.0000001921Highly InformativeDirect
Mammalian Phenotype (MP)increased interferon-gamma secretion0.00000117Highly InformativeDirect
Mammalian Phenotype (MP)impaired adaptive thermogenesis0.000001694Highly InformativeDirect
Mammalian Phenotype (MP)increased percent body fat/body weight0.000005585Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating insulin-like growth factor I level0.000005926Highly InformativeDirect
Mammalian Phenotype (MP)obese0.00002239Highly InformativeDirect
Mammalian Phenotype (MP)abnormal corpus luteum morphology0.00003301Highly InformativeDirect
Mammalian Phenotype (MP)increased total body fat amount0.0000873Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating triglyceride level0.0001341Highly InformativeDirect
Mammalian Phenotype (MP)abnormal endocrine pancreas secretion0.0001708Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pancreatic beta cell physiology0.0002421Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating insulin level0.0002927Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pancreatic islet morphology0.0004742Highly InformativeDirect
Mammalian Phenotype (MP)abnormal fat pad morphology0.0007004Highly InformativeDirect
Mammalian Phenotype (MP)abnormal food intake0.002601Highly InformativeInherited
Mammalian Phenotype (MP)abnormal liver size0.08216Highly InformativeInherited

Document: MP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0Moderately InformativeDirect
Zebrafish Anatomy (ZA)portion of organism substance0Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation0Moderately InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm0.0000000003604Least InformativeDirect
DomainSH2 domain0InformativeDirect
Molecular functionDNA-binding0Least InformativeDirect
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0.000003791Moderately InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation0.00036Moderately InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR015988 SSF47655 Protein matches
Abstract

This entry represents a domain consisting of four long helices that forms a bundle with a left-handed twist (coiled coil), in a right-handed superhelix.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a STAT domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the STAT superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]