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STAT superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   STAT-like [ 47654] (6)
Superfamily:   STAT [ 47655]
Families:   STAT [ 47656] (3)


Superfamily statistics
Genomes (164) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 711 1,751 3
Proteins 701 1,732 3


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.079 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.3646 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.8588 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 0.5482 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.8701 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.206 Least Informative Inherited
Biological Process (BP) cell differentiation 0 Moderately Informative Direct
Biological Process (BP) cell communication 0 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0 Moderately Informative Direct
Biological Process (BP) single organism signaling 0 Moderately Informative Direct
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.000000000000003734 Moderately Informative Direct
Biological Process (BP) animal organ development 0.0000000000006237 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.00000000001094 Moderately Informative Direct
Biological Process (BP) defense response 0.0000000001481 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0.0000000001741 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 0.0000000002268 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.0000000004399 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0.000000001337 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.000000004052 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.00000001453 Moderately Informative Direct
Biological Process (BP) reproduction 0.0000001628 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.000003578 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 0.0001307 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 0.0002865 Moderately Informative Direct
Biological Process (BP) single-organism transport 0.0009983 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.001069 Moderately Informative Inherited
Biological Process (BP) tissue development 0.02369 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.001664 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.008936 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.1092 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.02798 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.07885 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.007728 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.001954 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.1427 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.126 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.2774 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.01156 Moderately Informative Inherited
Biological Process (BP) nitrogen compound transport 0.2368 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.5107 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.004616 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.0225 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.05169 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.08972 Moderately Informative Inherited
Biological Process (BP) gene expression 0.1507 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) regulation of apoptotic process 0 Informative Direct
Biological Process (BP) regulation of cell differentiation 0 Informative Direct
Biological Process (BP) hemopoiesis 0 Informative Direct
Biological Process (BP) intracellular signal transduction 0 Informative Direct
Biological Process (BP) regulation of cell proliferation 0 Informative Direct
Biological Process (BP) immune response 0.00000000000004577 Informative Direct
Biological Process (BP) regulation of hydrolase activity 0.0000000000003143 Informative Direct
Biological Process (BP) cell activation 0.0000000000009054 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.000000000001495 Informative Direct
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 0.0000000002952 Informative Direct
Biological Process (BP) positive regulation of gene expression 0.000000001237 Informative Direct
Biological Process (BP) cell death 0.000000001446 Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.00000003411 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0.00000004975 Informative Direct
Biological Process (BP) response to nitrogen compound 0.00000007929 Informative Direct
Biological Process (BP) positive regulation of immune system process 0.0000007966 Informative Direct
Biological Process (BP) cellular response to hormone stimulus 0.000001995 Informative Direct
Biological Process (BP) response to extracellular stimulus 0.000002848 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.000006353 Informative Direct
Biological Process (BP) positive regulation of developmental process 0.00001505 Informative Direct
Biological Process (BP) lipid localization 0.00002084 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0.00002166 Informative Direct
Biological Process (BP) regulation of proteolysis 0.0000287 Informative Direct
Biological Process (BP) system process 0.00004553 Informative Direct
Biological Process (BP) cell surface receptor signaling pathway 0.00004778 Informative Direct
Biological Process (BP) cellular ketone metabolic process 0.00006259 Informative Direct
Biological Process (BP) generation of neurons 0.00006466 Informative Direct
Biological Process (BP) behavior 0.00008803 Informative Direct
Biological Process (BP) negative regulation of signaling 0.00009955 Informative Direct
Biological Process (BP) transcription, DNA-templated 0.0001322 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.0001559 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.0001896 Informative Direct
Biological Process (BP) protein localization to organelle 0.0008287 Informative Direct
Biological Process (BP) single-organism cellular localization 0.03391 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.002597 Informative Inherited
Biological Process (BP) growth 0.06764 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.01713 Informative Inherited
Biological Process (BP) intracellular transport 0.1395 Informative Inherited
Biological Process (BP) central nervous system development 1 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.07434 Informative Inherited
Biological Process (BP) regulation of cell cycle 0.01469 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.3434 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.04459 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 0.2822 Informative Inherited
Biological Process (BP) response to oxidative stress 0.2509 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.4325 Informative Inherited
Biological Process (BP) localization of cell 0.03868 Informative Inherited
Biological Process (BP) embryo development 1 Informative Inherited
Biological Process (BP) response to wounding 0.6658 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.2807 Informative Inherited
Biological Process (BP) regulation of growth 0.001145 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.1509 Informative Inherited
Biological Process (BP) regulation of defense response 0.001979 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.01353 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.06007 Informative Inherited
Biological Process (BP) regulation of nervous system development 1 Informative Inherited
Biological Process (BP) single organism reproductive process 0.2857 Informative Inherited
Biological Process (BP) reproductive system development 0.4489 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.4503 Informative Inherited
Biological Process (BP) cell development 1 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.7807 Informative Inherited
Biological Process (BP) multi-organism reproductive process 0.002555 Informative Inherited
Biological Process (BP) protein transport 0.00863 Informative Inherited
Biological Process (BP) immune effector process 1 Informative Inherited
Biological Process (BP) movement of cell or subcellular component 0.1818 Informative Inherited
Biological Process (BP) locomotion 0.03104 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.5299 Informative Inherited
Biological Process (BP) cytokine-mediated signaling pathway 0 Highly Informative Direct
Biological Process (BP) response to nutrient levels 0 Highly Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0 Highly Informative Direct
Biological Process (BP) apoptotic process 0 Highly Informative Direct
Biological Process (BP) response to peptide hormone 0 Highly Informative Direct
Biological Process (BP) lymphocyte activation 0 Highly Informative Direct
Biological Process (BP) response to organophosphorus 0.000000000000001925 Highly Informative Direct
Biological Process (BP) cell proliferation 0.000000000000003734 Highly Informative Direct
Biological Process (BP) regulation of smooth muscle cell proliferation 0.00000000000002436 Highly Informative Direct
Biological Process (BP) response to purine-containing compound 0.0000000000001109 Highly Informative Direct
Biological Process (BP) positive regulation of proteolysis 0.00000000000171 Highly Informative Direct
Biological Process (BP) regulation of hemopoiesis 0.000000000003442 Highly Informative Direct
Biological Process (BP) kidney development 0.00000000003356 Highly Informative Direct
Biological Process (BP) ovulation cycle process 0.0000000001233 Highly Informative Direct
Biological Process (BP) leukocyte differentiation 0.0000000001643 Highly Informative Direct
Biological Process (BP) positive regulation of mitotic cell cycle 0.000000000165 Highly Informative Direct
Biological Process (BP) positive regulation of lymphocyte activation 0.0000000001672 Highly Informative Direct
Biological Process (BP) positive regulation of homeostatic process 0.000000004178 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular signal transduction 0.000000007549 Highly Informative Direct
Biological Process (BP) innate immune response 0.000000009105 Highly Informative Direct
Biological Process (BP) response to hydrogen peroxide 0.0000000406 Highly Informative Direct
Biological Process (BP) maintenance of location 0.00000005555 Highly Informative Direct
Biological Process (BP) cellular response to organonitrogen compound 0.00000006575 Highly Informative Direct
Biological Process (BP) negative regulation of homeostatic process 0.000000513 Highly Informative Direct
Biological Process (BP) gastrulation 0.0000006576 Highly Informative Direct
Biological Process (BP) single-organism nuclear import 0.000001124 Highly Informative Direct
Biological Process (BP) cellular hormone metabolic process 0.000001217 Highly Informative Direct
Biological Process (BP) sensory organ morphogenesis 0.000001359 Highly Informative Direct
Biological Process (BP) protein localization to nucleus 0.000003579 Highly Informative Direct
Biological Process (BP) sex differentiation 0.00001095 Highly Informative Direct
Biological Process (BP) carbohydrate homeostasis 0.00001289 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 0.00001714 Highly Informative Direct
Biological Process (BP) regulation of cell size 0.00002214 Highly Informative Direct
Biological Process (BP) positive regulation of response to external stimulus 0.00008637 Highly Informative Direct
Biological Process (BP) multicellular organismal homeostasis 0.000156 Highly Informative Direct
Biological Process (BP) protein import 0.0002093 Highly Informative Direct
Biological Process (BP) multi-multicellular organism process 0.0004115 Highly Informative Direct
Biological Process (BP) wound healing 0.0004437 Highly Informative Direct
Biological Process (BP) negative regulation of immune system process 0.0004488 Highly Informative Direct
Biological Process (BP) regulation of cysteine-type endopeptidase activity 0.08526 Highly Informative Inherited
Biological Process (BP) response to growth factor 1 Highly Informative Inherited
Biological Process (BP) regeneration 0.01047 Highly Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 1 Highly Informative Inherited
Biological Process (BP) neuron development 1 Highly Informative Inherited
Biological Process (BP) camera-type eye development 1 Highly Informative Inherited
Biological Process (BP) regulation of epithelial cell proliferation 0.008608 Highly Informative Inherited
Biological Process (BP) gliogenesis 0.003222 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.06102 Highly Informative Inherited
Biological Process (BP) positive regulation of apoptotic process 0.02342 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 0.0684 Highly Informative Inherited
Biological Process (BP) positive regulation of cell adhesion 0.01712 Highly Informative Inherited
Biological Process (BP) regulation of lymphocyte proliferation 0.01088 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.02558 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.02816 Highly Informative Inherited
Biological Process (BP) epithelial cell differentiation 0.3505 Highly Informative Inherited
Biological Process (BP) positive regulation of leukocyte proliferation 0.2066 Highly Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 0.003071 Highly Informative Inherited
Biological Process (BP) positive regulation of nervous system development 0.7762 Highly Informative Inherited
Biological Process (BP) positive regulation of cell development 1 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.04238 Highly Informative Inherited
Biological Process (BP) plasma membrane bounded cell projection organization 0.06643 Highly Informative Inherited
Biological Process (BP) developmental growth involved in morphogenesis 0.003946 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.9063 Highly Informative Inherited
Molecular Function (MF) binding 0.00000004209 Least Informative Direct
Molecular Function (MF) nucleic acid binding 0 Moderately Informative Direct
Molecular Function (MF) DNA binding 0 Informative Direct
Molecular Function (MF) transcription factor activity, sequence-specific DNA binding 0 Informative Direct
Molecular Function (MF) enzyme binding 0.00000000001572 Informative Direct
Molecular Function (MF) protein dimerization activity 0.000000001528 Informative Direct
Molecular Function (MF) identical protein binding 0.0009935 Informative Direct
Molecular Function (MF) receptor binding 0.01555 Informative Inherited
Molecular Function (MF) protein phosphatase binding 0.00000000003957 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0.00000003688 Highly Informative Direct
Molecular Function (MF) chromatin binding 0.000002349 Highly Informative Direct
Molecular Function (MF) cytokine receptor binding 0.00001996 Highly Informative Direct
Molecular Function (MF) G-protein coupled receptor binding 0.00002112 Highly Informative Direct
Molecular Function (MF) transcription regulatory region DNA binding 0.0004774 Highly Informative Direct
Molecular Function (MF) kinase binding 0.001191 Highly Informative Inherited
Molecular Function (MF) sequence-specific DNA binding 0.571 Highly Informative Inherited
Molecular Function (MF) double-stranded DNA binding 1 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.8038 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.5712 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.0003939 Moderately Informative Direct
Cellular Component (CC) cell projection 0.1583 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.1686 Moderately Informative Inherited
Cellular Component (CC) neuron projection 0.0004106 Informative Direct
Cellular Component (CC) dendrite 0.0000004644 Highly Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation0Moderately InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm0.0000000003389Least InformativeDirect
DomainSH2 domain0InformativeDirect
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationDNA-binding0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0.000004188Moderately InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation0.0004154Moderately InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR015988 SSF47655 Protein matches
Abstract

This entry represents a domain consisting of four long helices that forms a bundle with a left-handed twist (coiled coil), in a right-handed superhelix.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a STAT domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the STAT superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]