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N-terminal domain of cbl (N-cbl) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   N-cbl like [ 47667] (5)
Superfamily:   N-terminal domain of cbl (N-cbl) [ 47668]
Families:   N-terminal domain of cbl (N-cbl) [ 47669]


Superfamily statistics
Genomes (139) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 324 719 4
Proteins 324 717 4


Functional annotation
General category coiled coil
Detailed category The code refers to a 2-stranded_canonical_parallel_coiled_coils in the CC+ database. Please click on the link for more information and to visit the CC+ website.

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biological regulation 0.000008228 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0.001781 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 0.002856 Least Informative Inherited
Biological Process (BP) response to stimulus 0.006412 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.02127 Least Informative Inherited
Biological Process (BP) cellular protein modification process 0.000006627 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0.00001485 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.0000223 Moderately Informative Direct
Biological Process (BP) cell communication 0.00002267 Moderately Informative Direct
Biological Process (BP) single organism signaling 0.00009265 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.000184 Moderately Informative Direct
Biological Process (BP) regulation of signaling 0.007726 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.001417 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.05448 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.03388 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 0.0000005002 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.000005986 Informative Direct
Biological Process (BP) proteolysis 0.0001742 Informative Direct
Biological Process (BP) negative regulation of signaling 0.0001987 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.0005829 Informative Direct
Biological Process (BP) protein modification by small protein conjugation 0.00000000007243 Highly Informative Direct
Biological Process (BP) modification-dependent macromolecule catabolic process 0.0000000005476 Highly Informative Direct
Biological Process (BP) cellular protein catabolic process 0.000002655 Highly Informative Direct
Molecular Function (MF) binding 0.00002538 Least Informative Direct
Molecular Function (MF) transferase activity 0.000572 Least Informative Direct
Molecular Function (MF) receptor binding 0.000009318 Informative Direct
Molecular Function (MF) enzyme binding 0.001868 Informative Inherited
Molecular Function (MF) ubiquitin-like protein transferase activity 0.0000000005535 Highly Informative Direct
Molecular Function (MF) kinase binding 0.000000006934 Highly Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processUbl conjugation pathway0Moderately InformativeDirect
DomainRepeat0.000001804Least InformativeDirect
DomainZinc-finger0.00000000000462Moderately InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0.0000000004633Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Post-translational modificationTransferase0.000000007495Least InformativeDirect
Post-translational modificationPhosphoprotein0.0000002701Least InformativeDirect
Post-translational modificationUbl conjugation0.0000000000004039Moderately InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR003153 SSF47668 Protein matches
Abstract

Cbl adaptor proteins are RING-type E3 ubiquitin ligases. Cbl may be involved in the negative regulation of thymocyte development, targeting its substrate for ubiquitination [PubMed11864842]. The ubiquitin ligase activity of Cbl, and of its homologue Cbl-b, plays a role in the negative regulation of upstream kinases, such as Lck, Syk and PI3K, in T and B cells [PubMed12787751]. Cbl can interact with the EGF receptor (EGFR), causing the ubiquitination of the receptor following EGF ligand binding and Grb2 association. Ubiquitination is required for ligand-induced endocytosis of the EGFR [PubMed15194809].

The N-terminal region is composed of three evolutionarily conserved domains: an N-terminal four-helix bundle domain, an EF Hand-like domain and a SH2-like domain, which together are known to bind to phosphorylated tyrosine residues. This entry represents the N-terminal four-helical bundle domain.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a N-terminal domain of cbl (N-cbl) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the N-terminal domain of cbl (N-cbl) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]