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N-terminal domain of cbl (N-cbl) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   N-cbl like [ 47667] (5)
Superfamily:   N-terminal domain of cbl (N-cbl) [ 47668]
Families:   N-terminal domain of cbl (N-cbl) [ 47669]


Superfamily statistics
Genomes (137) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 320 719 4
Proteins 320 717 4


Functional annotation
General category coiled coil
Detailed category The code refers to a 2-stranded_canonical_parallel_coiled_coils in the CC+ database. Please click on the link for more information and to visit the CC+ website.

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biological regulation 0.000002163 Least Informative Direct
Biological Process (BP) macromolecule metabolic process 0.002086 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.01643 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 0.001303 Least Informative Inherited
Biological Process (BP) response to stimulus 0.004529 Least Informative Inherited
Biological Process (BP) cellular protein modification process 0.000004382 Moderately Informative Direct
Biological Process (BP) cell communication 0.00002274 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0.00001534 Moderately Informative Direct
Biological Process (BP) single organism signaling 0.0001008 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.0001382 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.00002361 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0.03757 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.001476 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.0545 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.00812 Moderately Informative Inherited
Biological Process (BP) proteolysis 0.0002049 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.000006213 Informative Direct
Biological Process (BP) negative regulation of signaling 0.0002028 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0.0000004991 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.0007016 Informative Direct
Biological Process (BP) protein modification by small protein conjugation 0.00000000004821 Highly Informative Direct
Biological Process (BP) modification-dependent macromolecule catabolic process 0.0000000004047 Highly Informative Direct
Biological Process (BP) proteolysis involved in cellular protein catabolic process 0.0000000006245 Highly Informative Direct
Molecular Function (MF) binding 0.00006122 Least Informative Direct
Molecular Function (MF) transferase activity 0.0004237 Least Informative Direct
Molecular Function (MF) receptor binding 0.000005263 Informative Direct
Molecular Function (MF) enzyme binding 0.001364 Informative Inherited
Molecular Function (MF) ubiquitin-like protein transferase activity 0.000000000394 Highly Informative Direct
Molecular Function (MF) kinase binding 0.000000005368 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)RING-type E3 ubiquitin transferase0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processUbl conjugation pathway0Moderately InformativeDirect
DomainRepeat0.000001849Least InformativeDirect
DomainZinc-finger0.000000000004866Moderately InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0.0000000004559Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Post-translational modificationTransferase0.000000007591Least InformativeDirect
Post-translational modificationPhosphoprotein0.0000002558Least InformativeDirect
Post-translational modificationUbl conjugation0.00000000000007561Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR003153 SSF47668 Protein matches
Abstract

Cbl adaptor proteins are RING-type E3 ubiquitin ligases. Cbl may be involved in the negative regulation of thymocyte development, targeting its substrate for ubiquitination [PubMed11864842]. The ubiquitin ligase activity of Cbl, and of its homologue Cbl-b, plays a role in the negative regulation of upstream kinases, such as Lck, Syk and PI3K, in T and B cells [PubMed12787751]. Cbl can interact with the EGF receptor (EGFR), causing the ubiquitination of the receptor following EGF ligand binding and Grb2 association. Ubiquitination is required for ligand-induced endocytosis of the EGFR [PubMed15194809].

The N-terminal region is composed of three evolutionarily conserved domains: an N-terminal four-helix bundle domain, an EF Hand-like domain and a SH2-like domain, which together are known to bind to phosphorylated tyrosine residues. This entry represents the N-terminal four-helical bundle domain.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a N-terminal domain of cbl (N-cbl) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the N-terminal domain of cbl (N-cbl) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]