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SAM/Pointed domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   SAM domain-like [ 47768] (16)
Superfamily:   SAM/Pointed domain [ 47769] (3)
Families:   Pointed domain [ 47770] (6)
  SAM (sterile alpha motif) domain [ 47773] (15)
  Variant SAM domain [ 158526] (2)


Superfamily statistics
Genomes (515) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 17,420 18,588 33
Proteins 15,115 16,171 33


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details) Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.000001653 Least Informative Direct
Biological Process (BP) response to stimulus 0.00002109 Least Informative Direct
Biological Process (BP) macromolecule metabolic process 0.00003046 Least Informative Direct
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.006298 Least Informative Inherited
Biological Process (BP) signaling 0 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.00000000000003068 Moderately Informative Direct
Biological Process (BP) cell communication 0.000000000001458 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 0.0000000008385 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.00000000109 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.000000001758 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.0000003768 Moderately Informative Direct
Biological Process (BP) reproduction 0.000003313 Moderately Informative Direct
Biological Process (BP) cellular developmental process 0.000005027 Moderately Informative Direct
Biological Process (BP) regulation of biosynthetic process 0.916 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) nucleoside phosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.05339 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.2478 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.3191 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.004298 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.5802 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) system development 0.005437 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.03094 Moderately Informative Inherited
Biological Process (BP) amide biosynthetic process 0.6157 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 0.515 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.315 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.4013 Moderately Informative Inherited
Biological Process (BP) immune system process 0.01359 Moderately Informative Inherited
Biological Process (BP) response to stress 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.7452 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.3932 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.1717 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.9592 Moderately Informative Inherited
Biological Process (BP) organophosphate biosynthetic process 0.04753 Moderately Informative Inherited
Biological Process (BP) single-organism transport 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) purine-containing compound metabolic process 0.2777 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0 Informative Direct
Biological Process (BP) locomotion 0.0000000000071 Informative Direct
Biological Process (BP) organelle fission 0.000000001533 Informative Direct
Biological Process (BP) phosphorylation 0.0000005024 Informative Direct
Biological Process (BP) regulation of transmembrane transport 0.0000006734 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.000004075 Informative Direct
Biological Process (BP) cell cycle process 0.000005047 Informative Direct
Biological Process (BP) behavior 0.00000964 Informative Direct
Biological Process (BP) generation of neurons 0.00001171 Informative Direct
Biological Process (BP) multi-organism reproductive process 0.00001626 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0.00002344 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0.00002481 Informative Direct
Biological Process (BP) regulation of ion transport 0.0000511 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.0001269 Informative Direct
Biological Process (BP) cell adhesion 0.0002769 Informative Direct
Biological Process (BP) cell surface receptor signaling pathway 0.0002999 Informative Direct
Biological Process (BP) regulation of nervous system development 0.0004511 Informative Direct
Biological Process (BP) epithelium development 0.0005327 Informative Direct
Biological Process (BP) membrane lipid metabolic process 0.0006217 Informative Direct
Biological Process (BP) regulation of organelle organization 0.0006263 Informative Direct
Biological Process (BP) regulation of phosphorylation 0.0008845 Informative Direct
Biological Process (BP) regulation of intracellular signal transduction 0.0009821 Informative Direct
Biological Process (BP) regulation of hydrolase activity 0.004859 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.1337 Informative Inherited
Biological Process (BP) single organism reproductive process 0.01781 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 1 Informative Inherited
Biological Process (BP) circulatory system development 0.01436 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.8028 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.2515 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.4983 Informative Inherited
Biological Process (BP) growth 0.1635 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.9527 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.8374 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.9221 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 1 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.06215 Informative Inherited
Biological Process (BP) nucleobase-containing compound catabolic process 0.07021 Informative Inherited
Biological Process (BP) regulation of cell differentiation 0.02706 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.2284 Informative Inherited
Biological Process (BP) positive regulation of immune system process 1 Informative Inherited
Biological Process (BP) regulation of protein modification process 0.001018 Informative Inherited
Biological Process (BP) secondary metabolic process 0.2771 Informative Inherited
Biological Process (BP) pigment metabolic process 0.04616 Informative Inherited
Biological Process (BP) immune response 0.9717 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.04449 Informative Inherited
Biological Process (BP) positive regulation of transport 0.868 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.1565 Informative Inherited
Biological Process (BP) central nervous system development 0.04454 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.002702 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.01055 Informative Inherited
Biological Process (BP) regulation of locomotion 0.3025 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 0.07259 Informative Inherited
Biological Process (BP) organophosphate catabolic process 0.01037 Informative Inherited
Biological Process (BP) phospholipid metabolic process 0.4339 Informative Inherited
Biological Process (BP) microtubule-based process 0.551 Informative Inherited
Biological Process (BP) single-organism intracellular transport 0.6185 Informative Inherited
Biological Process (BP) system process 1 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.582 Informative Inherited
Biological Process (BP) cell death 0.07966 Informative Inherited
Biological Process (BP) DNA metabolic process 0.02405 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 0.8212 Informative Inherited
Biological Process (BP) response to inorganic substance 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.004645 Informative Inherited
Biological Process (BP) cell development 0.001702 Informative Inherited
Biological Process (BP) spermatogenesis 0 Highly Informative Direct
Biological Process (BP) DNA methylation or demethylation 0 Highly Informative Direct
Biological Process (BP) cell projection organization 0.00000000000006134 Highly Informative Direct
Biological Process (BP) meiotic cell cycle process 0.000000000001344 Highly Informative Direct
Biological Process (BP) angiogenesis 0.000000000008551 Highly Informative Direct
Biological Process (BP) regulation of transmembrane transporter activity 0.00000000001157 Highly Informative Direct
Biological Process (BP) neuron development 0.00000000003178 Highly Informative Direct
Biological Process (BP) chemotaxis 0.00000000003346 Highly Informative Direct
Biological Process (BP) macromolecule methylation 0.00000000004484 Highly Informative Direct
Biological Process (BP) multi-organism behavior 0.000000001173 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.000000001203 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 0.000000002184 Highly Informative Direct
Biological Process (BP) positive regulation of transmembrane transport 0.000000006084 Highly Informative Direct
Biological Process (BP) positive regulation of ion transport 0.00000002236 Highly Informative Direct
Biological Process (BP) sphingolipid biosynthetic process 0.0000000911 Highly Informative Direct
Biological Process (BP) nucleoside triphosphate catabolic process 0.0000001075 Highly Informative Direct
Biological Process (BP) positive regulation of transporter activity 0.0000005994 Highly Informative Direct
Biological Process (BP) deoxyribonucleoside triphosphate metabolic process 0.0000008111 Highly Informative Direct
Biological Process (BP) positive regulation of cellular component biogenesis 0.000007375 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.00001772 Highly Informative Direct
Biological Process (BP) ceramide metabolic process 0.00004152 Highly Informative Direct
Biological Process (BP) apoptotic process 0.00004634 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 0.00006171 Highly Informative Direct
Biological Process (BP) deoxyribonucleotide metabolic process 0.00009697 Highly Informative Direct
Biological Process (BP) positive regulation of nervous system development 0.0001437 Highly Informative Direct
Biological Process (BP) nucleotide catabolic process 0.0002659 Highly Informative Direct
Biological Process (BP) single-organism behavior 0.000377 Highly Informative Direct
Biological Process (BP) purine-containing compound catabolic process 0.0006182 Highly Informative Direct
Biological Process (BP) regulation of cation transmembrane transport 1 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 0.2785 Highly Informative Inherited
Biological Process (BP) regulation of binding 0.07154 Highly Informative Inherited
Biological Process (BP) regulation of calcium ion transport 0.1086 Highly Informative Inherited
Biological Process (BP) positive regulation of GTPase activity 1 Highly Informative Inherited
Biological Process (BP) negative regulation of cell development 0.2897 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular signal transduction 0.5063 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.06012 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 0.2761 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.001671 Highly Informative Inherited
Biological Process (BP) regulation of response to wounding 0.2289 Highly Informative Inherited
Biological Process (BP) tube morphogenesis 0.2087 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.05185 Highly Informative Inherited
Biological Process (BP) sensory organ morphogenesis 0.2138 Highly Informative Inherited
Biological Process (BP) innate immune response 0.2837 Highly Informative Inherited
Biological Process (BP) phenol-containing compound metabolic process 0.01783 Highly Informative Inherited
Biological Process (BP) negative regulation of cytoskeleton organization 0.003137 Highly Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 0.006556 Highly Informative Inherited
Biological Process (BP) cell maturation 0.3103 Highly Informative Inherited
Biological Process (BP) regulation of epithelial cell migration 0.03082 Highly Informative Inherited
Biological Process (BP) deoxyribose phosphate metabolic process 0.002741 Highly Informative Inherited
Biological Process (BP) microtubule-based movement 0.8034 Highly Informative Inherited
Biological Process (BP) small GTPase mediated signal transduction 0.3662 Highly Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 1 Highly Informative Inherited
Biological Process (BP) cell migration 0.04433 Highly Informative Inherited
Biological Process (BP) ammonium ion metabolic process 0.001422 Highly Informative Inherited
Biological Process (BP) glycoprotein metabolic process 0.5118 Highly Informative Inherited
Biological Process (BP) macromolecule glycosylation 0.6941 Highly Informative Inherited
Biological Process (BP) response to calcium ion 0.002238 Highly Informative Inherited
Biological Process (BP) detection of stimulus 0.2221 Highly Informative Inherited
Molecular Function (MF) transferase activity 0.000000000000007904 Least Informative Direct
Molecular Function (MF) binding 0.00000000000006362 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) protein binding 0.000000004127 Moderately Informative Direct
Molecular Function (MF) nucleic acid binding 0.0001407 Moderately Informative Direct
Molecular Function (MF) molecular function regulator 0.02068 Moderately Informative Inherited
Molecular Function (MF) structural molecule activity 0.09468 Moderately Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 1 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.6353 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 1 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 1 Moderately Informative Inherited
Molecular Function (MF) signal transducer activity 0 Informative Direct
Molecular Function (MF) molecular transducer activity 0.0000000000443 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.0000001473 Informative Direct
Molecular Function (MF) transcription factor activity, sequence-specific DNA binding 0.00001824 Informative Direct
Molecular Function (MF) kinase activity 0.0001791 Informative Direct
Molecular Function (MF) receptor binding 0.9438 Informative Inherited
Molecular Function (MF) purine nucleotide binding 0.2058 Informative Inherited
Molecular Function (MF) phosphoric ester hydrolase activity 0.68 Informative Inherited
Molecular Function (MF) enzyme activator activity 0.0086 Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 1 Informative Inherited
Molecular Function (MF) DNA binding 0.01714 Informative Inherited
Molecular Function (MF) transmembrane signaling receptor activity 0 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0.00000009197 Highly Informative Direct
Molecular Function (MF) GTPase regulator activity 0.00003778 Highly Informative Direct
Molecular Function (MF) transferase activity, transferring pentosyl groups 0.002548 Highly Informative Inherited
Molecular Function (MF) transcription regulatory region DNA binding 0.01488 Highly Informative Inherited
Molecular Function (MF) sequence-specific DNA binding 1 Highly Informative Inherited
Cellular Component (CC) membrane 0.008322 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.08361 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) cell projection 0.0000002955 Moderately Informative Direct
Cellular Component (CC) intrinsic component of membrane 0.0002194 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.0007424 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0.06218 Moderately Informative Inherited
Cellular Component (CC) transferase complex 0.2536 Moderately Informative Inherited
Cellular Component (CC) whole membrane 0.5791 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.4149 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.9753 Moderately Informative Inherited
Cellular Component (CC) vesicle 0.01935 Moderately Informative Inherited
Cellular Component (CC) ribonucleoprotein granule 0 Informative Direct
Cellular Component (CC) synapse 0 Informative Direct
Cellular Component (CC) cytoplasmic region 0.00000001241 Informative Direct
Cellular Component (CC) endosome 0.00002299 Informative Direct
Cellular Component (CC) apical part of cell 0.00002756 Informative Direct
Cellular Component (CC) neuron projection 0.0005343 Informative Direct
Cellular Component (CC) site of polarized growth 0.0006107 Informative Direct
Cellular Component (CC) plasma membrane region 0.0105 Informative Inherited
Cellular Component (CC) cilium 0.5379 Informative Inherited
Cellular Component (CC) cell projection part 0.01692 Informative Inherited
Cellular Component (CC) cytoplasmic vesicle part 0.04688 Informative Inherited
Cellular Component (CC) actin cytoskeleton 0.007781 Informative Inherited
Cellular Component (CC) cell junction 0.00748 Informative Inherited
Cellular Component (CC) ubiquitin ligase complex 0.007369 Informative Inherited
Cellular Component (CC) pole plasm 0 Highly Informative Direct
Cellular Component (CC) nuclear ubiquitin ligase complex 0.000000000445 Highly Informative Direct
Cellular Component (CC) intrinsic component of plasma membrane 0.0000002169 Highly Informative Direct
Cellular Component (CC) cell-substrate junction 0.00001284 Highly Informative Direct
Cellular Component (CC) dendrite 0.0004882 Highly Informative Direct
Cellular Component (CC) early endosome 0.0008808 Highly Informative Direct
Cellular Component (CC) receptor complex 0.1275 Highly Informative Inherited
Cellular Component (CC) endosome membrane 0.001375 Highly Informative Inherited
Cellular Component (CC) cortical cytoskeleton 0.01854 Highly Informative Inherited
Cellular Component (CC) anchoring junction 0.04848 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0.558Least InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0.007561Moderately InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0.00471Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep1Moderately InformativeInherited
Enzyme Commission (EC)Receptor protein-tyrosine kinase0.00000000001004InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-3,4,5-trisphosphate 5-phospha0Highly InformativeDirect
Enzyme Commission (EC)Diacylglycerol kinase0Highly InformativeDirect
Enzyme Commission (EC)Mitogen-activated protein kinase kinase kinase0.0000000000009763Highly InformativeDirect
Enzyme Commission (EC)Transferases for other substituted phosphate group0.01424Highly InformativeInherited

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.393Least InformativeInherited
Disease Ontology (DO)breast carcinoma0.48InformativeInherited
Disease Ontology (DO)invasive ductal carcinoma0.0003884Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.2124Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.4564Least InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.1946Moderately InformativeInherited
Mammalian Phenotype (MP)embryo phenotype0.2237Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development0.3599Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell differentiation0.2436InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.07444Least InformativeInherited
Worm Phenotype (WP)chemical response variant0.1018Moderately InformativeInherited
Worm Phenotype (WP)aldicarb response variant0.0001153InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)metabolism and growth0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)cell number defective0.04757InformativeInherited
Fly Phenotype (FP)size defective0.144InformativeInherited
Fly Phenotype (FP)neoplasia0.0001788Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)multi-tissue structure0.8332Moderately InformativeInherited
Xenopus ANatomical entity (XAN)circulatory system0.0247InformativeInherited
Xenopus ANatomical entity (XAN)blood vessel0.02387Highly InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0.003354Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0.008083Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Pentosyltransferases0.01849InformativeInherited
Enzyme Commission (EC)Diacylglycerol kinase (ATP)0Highly InformativeDirect
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase0.000000000001537Highly InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0.000000000005837Highly InformativeDirect
Enzyme Commission (EC)Transferases for other substituted phosphate groups0.01019Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processApoptosis0Moderately InformativeDirect
Biological processDifferentiation0Moderately InformativeDirect
Biological processTranscription regulation0Moderately InformativeDirect
Biological processImmunity0.0000000000003351Moderately InformativeDirect
Biological processProtein transport0.00004Moderately InformativeDirect
Biological processLipid metabolism0.51Moderately InformativeInherited
Biological processIon transport0.823Moderately InformativeInherited
Biological processCell adhesion0InformativeDirect
Biological processMeiosis0InformativeDirect
Biological processNeurogenesis0InformativeDirect
Biological processAngiogenesis0.0000000002673InformativeDirect
Biological processTranslation regulation0.000002166InformativeDirect
Biological processRNA-mediated gene silencing0Highly InformativeDirect
Biological processSphingolipid metabolism0.00000000000002636Highly InformativeDirect
Biological processSpermatogenesis0.00000000002453Highly InformativeDirect
Biological processCalcium transport0.0000000004798Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentMembrane0.000122Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentEndosome0.00000001331Moderately InformativeDirect
Cellular componentCytoskeleton0.00000002113Moderately InformativeDirect
Coding sequence diversityAlternative splicing0.00000001572Least InformativeDirect
Coding sequence diversityAlternative promoter usage0.000001325Moderately InformativeDirect
DiseaseProto-oncogene0.00006818Moderately InformativeDirect
DiseaseTumor suppressor0.0001255Moderately InformativeDirect
DomainRepeat0Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainCoiled coil0.0000000003441Moderately InformativeDirect
DomainANK repeat0InformativeDirect
DomainSH3 domain0InformativeDirect
DomainSH3-binding0.0000000002115InformativeDirect
DomainSH2 domain0.00003317InformativeDirect
Molecular functionDNA-binding0.00000000000001459Least InformativeDirect
Molecular functionZinc0.0001909Least InformativeDirect
Molecular functionActin-binding0.0000005214InformativeDirect
Post-translational modificationTransferase0.1462Least InformativeInherited
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationRepressor0Moderately InformativeDirect
Post-translational modificationActivator0.000004049Moderately InformativeDirect
Post-translational modificationGTPase activation0.0000000000005782InformativeDirect
Post-translational modificationChromatin regulator0.000000006514InformativeDirect
Post-translational modificationTyrosine-protein kinase0Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation0.0005644Moderately InformativeDirect
Post-translational modificationHydroxylation0.0004415InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR010993 SSF47769 Protein matches
Abstract

Sterile alpha motif (SAM) domains are known to be involved in diverse protein-protein interactions, associating with both SAM-containing and non-SAM-containing proteins pathway [PubMed14659692]. SAM domains exhibit a conserved structure, consisting of a 4-5-helical bundle of two orthogonally packed alpha-hairpins. However SAM domains display a diversity of function, being involved in interactions with proteins, DNA and RNA [PubMed12858164]. The name sterile alpha motif arose from its presence in proteins that are essential for yeast sexual differentiation. The SAM domain has had various names, including SPM, PTN (pointed), SEP (yeast sterility, Ets-related, PcG proteins), NCR (N-terminal conserved region) and HLH (helix-loop-helix) domain, all of which are related and can be classified as SAM domains.

SAM domains occur in eukaryotic and in some bacterial proteins. Structures have been determined for several proteins that contain SAM domains, including Ets-1 transcription factor, which plays a role in the development and invasion of tumour cells by regulating the expression of matrix-degrading proteases [PubMed14704859]; Etv6 transcription factor, gene rearrangements of which have been demonstrated in several malignancies [PubMed9031109]; EphA4 receptor tyrosine kinase, which is believed to be important for the correct localization of a motoneuron pool to a specific position in the spinal cord [PubMed12577325]; EphB2 receptor, which is involved in spine morphogenesis via intersectin, Cdc42 and N-Wasp [PubMed12389031]; p73, a p53 homologue involved in neuronal development [PubMed14659698]; and polyhomeotic, which is a member of the Polycomb group of genes (Pc-G) required for the maintenance of the spatial expression pattern of homeotic genes [PubMed14499651].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 24 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a SAM/Pointed domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 24 hidden Markov models representing the SAM/Pointed domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]