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SAM/Pointed domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   SAM domain-like [ 47768] (16)
Superfamily:   SAM/Pointed domain [ 47769] (3)
Families:   Pointed domain [ 47770] (6)
  SAM (sterile alpha motif) domain [ 47773] (15)
  Variant SAM domain [ 158526] (2)


Superfamily statistics
Genomes (520) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 17,664 43,135 33
Proteins 15,309 36,552 33


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details) Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.00008067 Least Informative Direct
Biological Process (BP) response to stimulus 0.0001878 Least Informative Direct
Biological Process (BP) macromolecule metabolic process 0.0006965 Least Informative Direct
Biological Process (BP) primary metabolic process 0.06689 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 0.03995 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.9552 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.9674 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cell communication 0 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.00000000001774 Moderately Informative Direct
Biological Process (BP) single organism signaling 0.00000000009449 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 0.000000001946 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.000000002633 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.0000000101 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.0000000455 Moderately Informative Direct
Biological Process (BP) reproduction 0.000008348 Moderately Informative Direct
Biological Process (BP) cellular developmental process 0.0000133 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.0001043 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 0.5161 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.4926 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.04001 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.7101 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.0147 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.3658 Moderately Informative Inherited
Biological Process (BP) amide biosynthetic process 0.673 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.02933 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.2859 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.3105 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.06255 Moderately Informative Inherited
Biological Process (BP) immune system process 0.01388 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.2755 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.8379 Moderately Informative Inherited
Biological Process (BP) nucleoside phosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) purine-containing compound metabolic process 0.5246 Moderately Informative Inherited
Biological Process (BP) single-organism transport 1 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 1 Moderately Informative Inherited
Biological Process (BP) organophosphate biosynthetic process 0.065 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.9164 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.9883 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 1 Moderately Informative Inherited
Biological Process (BP) ion transport 0.9914 Moderately Informative Inherited
Biological Process (BP) system development 0.01018 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0 Informative Direct
Biological Process (BP) locomotion 0.00000000002307 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0.00000002577 Informative Direct
Biological Process (BP) phosphorylation 0.0000003912 Informative Direct
Biological Process (BP) regulation of transmembrane transport 0.000001365 Informative Direct
Biological Process (BP) multi-organism reproductive process 0.00000308 Informative Direct
Biological Process (BP) cell surface receptor signaling pathway 0.000005983 Informative Direct
Biological Process (BP) regulation of nervous system development 0.000006955 Informative Direct
Biological Process (BP) cell cycle process 0.000007856 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.000009285 Informative Direct
Biological Process (BP) behavior 0.00001256 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0.00004158 Informative Direct
Biological Process (BP) regulation of ion transport 0.00005968 Informative Direct
Biological Process (BP) regulation of phosphorylation 0.0006298 Informative Direct
Biological Process (BP) membrane lipid metabolic process 0.0008416 Informative Direct
Biological Process (BP) regulation of hydrolase activity 0.006911 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.1584 Informative Inherited
Biological Process (BP) regulation of cellular localization 0.998 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.9749 Informative Inherited
Biological Process (BP) positive regulation of transport 0.8862 Informative Inherited
Biological Process (BP) cell-cell signaling 0.2542 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.05539 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.959 Informative Inherited
Biological Process (BP) regulation of cell differentiation 0.02046 Informative Inherited
Biological Process (BP) cell death 0.07315 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.6464 Informative Inherited
Biological Process (BP) cell development 0.01186 Informative Inherited
Biological Process (BP) tissue development 1 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.001133 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.1955 Informative Inherited
Biological Process (BP) growth 0.1867 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 1 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.1137 Informative Inherited
Biological Process (BP) regulation of protein modification process 0.001161 Informative Inherited
Biological Process (BP) nucleobase-containing compound catabolic process 0.08284 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.2365 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.5236 Informative Inherited
Biological Process (BP) sensory organ development 0.9534 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.001128 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.2962 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.7487 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.8926 Informative Inherited
Biological Process (BP) pigment metabolic process 0.05242 Informative Inherited
Biological Process (BP) immune effector process 0.4644 Informative Inherited
Biological Process (BP) immune response 1 Informative Inherited
Biological Process (BP) secondary metabolic process 0.2962 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.1661 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.2051 Informative Inherited
Biological Process (BP) regulation of locomotion 0.351 Informative Inherited
Biological Process (BP) generation of neurons 0.009937 Informative Inherited
Biological Process (BP) central nervous system development 0.08517 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.0218 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.05031 Informative Inherited
Biological Process (BP) organophosphate catabolic process 0.01275 Informative Inherited
Biological Process (BP) microtubule-based process 0.2522 Informative Inherited
Biological Process (BP) single-organism intracellular transport 0.3258 Informative Inherited
Biological Process (BP) system process 1 Informative Inherited
Biological Process (BP) single organism reproductive process 0.04006 Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 1 Informative Inherited
Biological Process (BP) phospholipid metabolic process 0.4704 Informative Inherited
Biological Process (BP) ammonium ion metabolic process 0.005841 Informative Inherited
Biological Process (BP) DNA metabolic process 0.01191 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 0.08653 Informative Inherited
Biological Process (BP) response to metal ion 0.8938 Informative Inherited
Biological Process (BP) metal ion transport 0.4803 Informative Inherited
Biological Process (BP) circulatory system development 0.01144 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.009961 Informative Inherited
Biological Process (BP) spermatogenesis 0 Highly Informative Direct
Biological Process (BP) plasma membrane bounded cell projection organization 0 Highly Informative Direct
Biological Process (BP) DNA methylation or demethylation 0 Highly Informative Direct
Biological Process (BP) nuclear division 0.000000000000001945 Highly Informative Direct
Biological Process (BP) meiotic cell cycle 0.0000000000006116 Highly Informative Direct
Biological Process (BP) chemotaxis 0.000000000008751 Highly Informative Direct
Biological Process (BP) macromolecule methylation 0.00000000002787 Highly Informative Direct
Biological Process (BP) angiogenesis 0.0000000000282 Highly Informative Direct
Biological Process (BP) regulation of transmembrane transporter activity 0.00000000003848 Highly Informative Direct
Biological Process (BP) neuron development 0.00000000004602 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.0000000002523 Highly Informative Direct
Biological Process (BP) multi-organism behavior 0.000000000288 Highly Informative Direct
Biological Process (BP) regulation of cation transmembrane transport 0.000000001975 Highly Informative Direct
Biological Process (BP) regulation of GTPase activity 0.000000002727 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 0.000000003432 Highly Informative Direct
Biological Process (BP) positive regulation of transmembrane transport 0.00000001379 Highly Informative Direct
Biological Process (BP) positive regulation of ion transport 0.00000002693 Highly Informative Direct
Biological Process (BP) sphingolipid biosynthetic process 0.000000137 Highly Informative Direct
Biological Process (BP) nucleoside triphosphate catabolic process 0.0000001957 Highly Informative Direct
Biological Process (BP) positive regulation of transporter activity 0.0000007039 Highly Informative Direct
Biological Process (BP) deoxyribonucleoside triphosphate metabolic process 0.000001488 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.00003877 Highly Informative Direct
Biological Process (BP) ceramide metabolic process 0.00005264 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 0.00005398 Highly Informative Direct
Biological Process (BP) positive regulation of cellular component biogenesis 0.00006777 Highly Informative Direct
Biological Process (BP) deoxyribonucleotide metabolic process 0.0001368 Highly Informative Direct
Biological Process (BP) nucleotide catabolic process 0.0003548 Highly Informative Direct
Biological Process (BP) biological adhesion 0.0005139 Highly Informative Direct
Biological Process (BP) negative regulation of cytoskeleton organization 0.0005168 Highly Informative Direct
Biological Process (BP) negative regulation of nervous system development 0.0006237 Highly Informative Direct
Biological Process (BP) purine-containing compound catabolic process 0.0007077 Highly Informative Direct
Biological Process (BP) single-organism behavior 0.0007218 Highly Informative Direct
Biological Process (BP) trans-synaptic signaling 0.0007692 Highly Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0.3773 Highly Informative Inherited
Biological Process (BP) regulation of binding 0.1136 Highly Informative Inherited
Biological Process (BP) regulation of calcium ion transport 0.1213 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 0.4558 Highly Informative Inherited
Biological Process (BP) apoptotic process 0.009173 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.06823 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.001728 Highly Informative Inherited
Biological Process (BP) positive regulation of nervous system development 0.001248 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.04147 Highly Informative Inherited
Biological Process (BP) negative regulation of cell development 0.411 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 0.2218 Highly Informative Inherited
Biological Process (BP) tube morphogenesis 0.1922 Highly Informative Inherited
Biological Process (BP) positive regulation of homeostatic process 0.07485 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular signal transduction 0.3675 Highly Informative Inherited
Biological Process (BP) phenol-containing compound metabolic process 0.02374 Highly Informative Inherited
Biological Process (BP) innate immune response 0.2057 Highly Informative Inherited
Biological Process (BP) negative regulation of supramolecular fiber organization 0.001451 Highly Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 0.006933 Highly Informative Inherited
Biological Process (BP) cell maturation 0.3488 Highly Informative Inherited
Biological Process (BP) regulation of epithelial cell migration 0.05649 Highly Informative Inherited
Biological Process (BP) deoxyribose phosphate metabolic process 0.003259 Highly Informative Inherited
Biological Process (BP) microtubule-based movement 0.8614 Highly Informative Inherited
Biological Process (BP) neurological system process 0.001334 Highly Informative Inherited
Biological Process (BP) small GTPase mediated signal transduction 0.3874 Highly Informative Inherited
Biological Process (BP) glycoprotein metabolic process 0.4622 Highly Informative Inherited
Biological Process (BP) macromolecule glycosylation 0.5772 Highly Informative Inherited
Biological Process (BP) divalent metal ion transport 0.03783 Highly Informative Inherited
Biological Process (BP) sensory organ morphogenesis 0.2701 Highly Informative Inherited
Molecular Function (MF) binding 0.00000000000002588 Least Informative Direct
Molecular Function (MF) transferase activity 0.00000000000004639 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) nucleic acid binding 0.0008527 Moderately Informative Direct
Molecular Function (MF) molecular function regulator 0.03226 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.7146 Moderately Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 1 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 1 Moderately Informative Inherited
Molecular Function (MF) structural molecule activity 0.111 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 1 Moderately Informative Inherited
Molecular Function (MF) signal transducer activity 0 Informative Direct
Molecular Function (MF) molecular transducer activity 0.0000000001561 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.0000007724 Informative Direct
Molecular Function (MF) transcription factor activity, sequence-specific DNA binding 0.00001666 Informative Direct
Molecular Function (MF) kinase activity 0.0007298 Informative Direct
Molecular Function (MF) receptor binding 0.164 Informative Inherited
Molecular Function (MF) purine nucleotide binding 0.2566 Informative Inherited
Molecular Function (MF) enzyme activator activity 0.009048 Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 1 Informative Inherited
Molecular Function (MF) DNA binding 0.01635 Informative Inherited
Molecular Function (MF) transmembrane signaling receptor activity 0 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0.000000000002864 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0.0000001018 Highly Informative Direct
Molecular Function (MF) GTPase regulator activity 0.00004273 Highly Informative Direct
Molecular Function (MF) transferase activity, transferring pentosyl groups 0.00239 Highly Informative Inherited
Molecular Function (MF) transcription regulatory region DNA binding 0.01832 Highly Informative Inherited
Molecular Function (MF) double-stranded DNA binding 0.8049 Highly Informative Inherited
Molecular Function (MF) sequence-specific DNA binding 1 Highly Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.06851 Least Informative Inherited
Cellular Component (CC) membrane 0.009139 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) macromolecular complex 0.6231 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.6995 Least Informative Inherited
Cellular Component (CC) cell projection 0.0000008833 Moderately Informative Direct
Cellular Component (CC) intrinsic component of membrane 0.00004218 Moderately Informative Direct
Cellular Component (CC) bounding membrane of organelle 0.0002523 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.0006035 Moderately Informative Direct
Cellular Component (CC) transferase complex 0.2975 Moderately Informative Inherited
Cellular Component (CC) vesicle 0.04731 Moderately Informative Inherited
Cellular Component (CC) whole membrane 0.7781 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.1415 Moderately Informative Inherited
Cellular Component (CC) ribonucleoprotein granule 0 Informative Direct
Cellular Component (CC) synapse 0 Informative Direct
Cellular Component (CC) cytoplasmic region 0.00000006263 Informative Direct
Cellular Component (CC) apical part of cell 0.00003528 Informative Direct
Cellular Component (CC) endosome 0.00004275 Informative Direct
Cellular Component (CC) plasma membrane bounded cell projection part 1 Informative Inherited
Cellular Component (CC) plasma membrane region 0.01506 Informative Inherited
Cellular Component (CC) cilium 0.6567 Informative Inherited
Cellular Component (CC) neuron projection 0.007533 Informative Inherited
Cellular Component (CC) cytoplasmic vesicle part 0.2885 Informative Inherited
Cellular Component (CC) ubiquitin ligase complex 0.01047 Informative Inherited
Cellular Component (CC) pole plasm 0 Highly Informative Direct
Cellular Component (CC) nuclear ubiquitin ligase complex 0.00000000123 Highly Informative Direct
Cellular Component (CC) intrinsic component of plasma membrane 0.000002523 Highly Informative Direct
Cellular Component (CC) dendrite 0.0001954 Highly Informative Direct
Cellular Component (CC) receptor complex 0.09694 Highly Informative Inherited
Cellular Component (CC) endosome membrane 0.001035 Highly Informative Inherited
Cellular Component (CC) cell-substrate adherens junction 0.4093 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0.558Least InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0.007561Moderately InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0.00471Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep1Moderately InformativeInherited
Enzyme Commission (EC)Receptor protein-tyrosine kinase0.00000000001004InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-3,4,5-trisphosphate 5-phospha0Highly InformativeDirect
Enzyme Commission (EC)Diacylglycerol kinase0Highly InformativeDirect
Enzyme Commission (EC)Mitogen-activated protein kinase kinase kinase0.0000000000009763Highly InformativeDirect
Enzyme Commission (EC)Transferases for other substituted phosphate group0.01424Highly InformativeInherited

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.4748Least InformativeInherited
Disease Ontology (DO)breast carcinoma0.4826InformativeInherited
Disease Ontology (DO)invasive ductal carcinoma0.0004261Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.2907Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.4814Least InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.2381Moderately InformativeInherited
Mammalian Phenotype (MP)embryo phenotype0.2753Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development0.4113Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell differentiation0.2428InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.0727Least InformativeInherited
Worm Phenotype (WP)chemical response variant0.09396Moderately InformativeInherited
Worm Phenotype (WP)aldicarb response variant0.000105InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)metabolism and growth0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)cell number defective0.007311InformativeInherited

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)multi-tissue structure0.7579Moderately InformativeInherited
Xenopus ANatomical entity (XAN)circulatory system0.01975Highly InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0.003614Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0.008677Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Pentosyltransferases0.0225InformativeInherited
Enzyme Commission (EC)Diacylglycerol kinase (ATP)0Highly InformativeDirect
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase0.000000000001651Highly InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0.000000000006681Highly InformativeDirect
Enzyme Commission (EC)Transferases for other substituted phosphate groups0.01071Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processApoptosis0Moderately InformativeDirect
Biological processDifferentiation0Moderately InformativeDirect
Biological processTranscription regulation0Moderately InformativeDirect
Biological processImmunity0.0000000000004837Moderately InformativeDirect
Biological processProtein transport0.00004162Moderately InformativeDirect
Biological processLipid metabolism0.5158Moderately InformativeInherited
Biological processIon transport0.829Moderately InformativeInherited
Biological processCell adhesion0InformativeDirect
Biological processMeiosis0InformativeDirect
Biological processNeurogenesis0InformativeDirect
Biological processAngiogenesis0.0000000002977InformativeDirect
Biological processTranslation regulation0.000002585InformativeDirect
Biological processRNA-mediated gene silencing0Highly InformativeDirect
Biological processSphingolipid metabolism0.00000000000003208Highly InformativeDirect
Biological processSpermatogenesis0.00000000006138Highly InformativeDirect
Biological processCalcium transport0.000000000648Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentMembrane0.0001858Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentEndosome0.0000000004609Moderately InformativeDirect
Cellular componentCytoskeleton0.00000002727Moderately InformativeDirect
Coding sequence diversityAlternative splicing0.00000001346Least InformativeDirect
Coding sequence diversityAlternative promoter usage0.000001619Moderately InformativeDirect
DiseaseProto-oncogene0.00008859Moderately InformativeDirect
DiseaseTumor suppressor0.0001757Moderately InformativeDirect
DomainRepeat0Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainCoiled coil0.000000000399Moderately InformativeDirect
DomainANK repeat0InformativeDirect
DomainSH3 domain0InformativeDirect
DomainSH3-binding0.0000000002103InformativeDirect
DomainSH2 domain0.00003355InformativeDirect
Molecular functionZinc0.0002291Least InformativeDirect
Post-translational modificationTransferase0.1354Least InformativeInherited
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationRepressor0Moderately InformativeDirect
Post-translational modificationDNA-binding0.000000000000006267Moderately InformativeDirect
Post-translational modificationActivator0.000004719Moderately InformativeDirect
Post-translational modificationGTPase activation0.000000000000604InformativeDirect
Post-translational modificationChromatin regulator0.00000000702InformativeDirect
Post-translational modificationActin-binding0.0000004901InformativeDirect
Post-translational modificationTyrosine-protein kinase0Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation0.0009237Moderately InformativeDirect
Post-translational modificationHydroxylation0.00045InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR010993 SSF47769 Protein matches
Abstract

Sterile alpha motif (SAM) domains are known to be involved in diverse protein-protein interactions, associating with both SAM-containing and non-SAM-containing proteins pathway [PubMed14659692]. SAM domains exhibit a conserved structure, consisting of a 4-5-helical bundle of two orthogonally packed alpha-hairpins. However SAM domains display a diversity of function, being involved in interactions with proteins, DNA and RNA [PubMed12858164]. The name sterile alpha motif arose from its presence in proteins that are essential for yeast sexual differentiation. The SAM domain has had various names, including SPM, PTN (pointed), SEP (yeast sterility, Ets-related, PcG proteins), NCR (N-terminal conserved region) and HLH (helix-loop-helix) domain, all of which are related and can be classified as SAM domains.

SAM domains occur in eukaryotic and in some bacterial proteins. Structures have been determined for several proteins that contain SAM domains, including Ets-1 transcription factor, which plays a role in the development and invasion of tumour cells by regulating the expression of matrix-degrading proteases [PubMed14704859]; Etv6 transcription factor, gene rearrangements of which have been demonstrated in several malignancies [PubMed9031109]; EphA4 receptor tyrosine kinase, which is believed to be important for the correct localization of a motoneuron pool to a specific position in the spinal cord [PubMed12577325]; EphB2 receptor, which is involved in spine morphogenesis via intersectin, Cdc42 and N-Wasp [PubMed12389031]; p73, a p53 homologue involved in neuronal development [PubMed14659698]; and polyhomeotic, which is a member of the Polycomb group of genes (Pc-G) required for the maintenance of the spatial expression pattern of homeotic genes [PubMed14499651].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 24 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a SAM/Pointed domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 24 hidden Markov models representing the SAM/Pointed domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]