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SAM/Pointed domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   SAM domain-like [ 47768] (16)
Superfamily:   SAM/Pointed domain [ 47769] (3)
Families:   Pointed domain [ 47770] (6)
  SAM (sterile alpha motif) domain [ 47773] (15)
  Variant SAM domain [ 158526] (2)


Superfamily statistics
Genomes (520) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 17,664 43,135 33
Proteins 15,309 36,552 33


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details) Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.000005866 Least Informative Direct
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0.09487 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.9312 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.9535 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.1588 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.001353 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 0.995 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 0.004741 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) reproduction 0.00003351 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.0000000003364 Moderately Informative Direct
Biological Process (BP) cell communication 0 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.000000005834 Moderately Informative Direct
Biological Process (BP) single organism signaling 0.0000000002226 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.0001836 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.000000001447 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.00000007404 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 0.000000000608 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.249 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.01653 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.7556 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.6869 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.05728 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.2207 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.0157 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.05501 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.02455 Moderately Informative Inherited
Biological Process (BP) amide biosynthetic process 0.7418 Moderately Informative Inherited
Biological Process (BP) animal organ development 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.2284 Moderately Informative Inherited
Biological Process (BP) immune system process 0.008845 Moderately Informative Inherited
Biological Process (BP) defense response 0.06674 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.2699 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.9435 Moderately Informative Inherited
Biological Process (BP) nucleoside phosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) purine-containing compound metabolic process 0.3727 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 1 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.8956 Moderately Informative Inherited
Biological Process (BP) organophosphate biosynthetic process 0.08335 Moderately Informative Inherited
Biological Process (BP) single-organism transport 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.5966 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.2371 Moderately Informative Inherited
Biological Process (BP) movement of cell or subcellular component 0.00007845 Informative Direct
Biological Process (BP) cell surface receptor signaling pathway 0.000003176 Informative Direct
Biological Process (BP) behavior 0.00001801 Informative Direct
Biological Process (BP) phosphorylation 0.000001865 Informative Direct
Biological Process (BP) cell cycle process 0.000006623 Informative Direct
Biological Process (BP) regulation of protein modification process 0.0001836 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.0000003313 Informative Direct
Biological Process (BP) regulation of transmembrane transport 0.0000001137 Informative Direct
Biological Process (BP) locomotion 0.00000000002556 Informative Direct
Biological Process (BP) regulation of phosphorylation 0.000434 Informative Direct
Biological Process (BP) regulation of ion transport 0.00001004 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0 Informative Direct
Biological Process (BP) multi-organism reproductive process 0.000006009 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0.00000000508 Informative Direct
Biological Process (BP) localization of cell 0.00003402 Informative Direct
Biological Process (BP) regulation of nervous system development 0.000002659 Informative Direct
Biological Process (BP) epithelium development 0.0007776 Informative Direct
Biological Process (BP) regulation of intracellular signal transduction 0.0005073 Informative Direct
Biological Process (BP) regulation of hydrolase activity 0.01433 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.0406 Informative Inherited
Biological Process (BP) regulation of cellular localization 1 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 1 Informative Inherited
Biological Process (BP) regulation of protein localization 1 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.09077 Informative Inherited
Biological Process (BP) cell death 0.1057 Informative Inherited
Biological Process (BP) circulatory system development 0.01951 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.7521 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.001219 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.2274 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.5264 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.2468 Informative Inherited
Biological Process (BP) single organism reproductive process 0.05918 Informative Inherited
Biological Process (BP) growth 0.3435 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.7699 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.6376 Informative Inherited
Biological Process (BP) system process 1 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 1 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.1968 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 0.04024 Informative Inherited
Biological Process (BP) generation of neurons 0.005482 Informative Inherited
Biological Process (BP) regulation of cell differentiation 0.02495 Informative Inherited
Biological Process (BP) positive regulation of immune system process 1 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.5118 Informative Inherited
Biological Process (BP) DNA metabolic process 0.01005 Informative Inherited
Biological Process (BP) pigment metabolic process 0.06331 Informative Inherited
Biological Process (BP) immune effector process 0.4374 Informative Inherited
Biological Process (BP) immune response 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.1953 Informative Inherited
Biological Process (BP) positive regulation of transport 0.6832 Informative Inherited
Biological Process (BP) cell development 0.001909 Informative Inherited
Biological Process (BP) central nervous system development 0.1764 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.02171 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.05003 Informative Inherited
Biological Process (BP) regulation of locomotion 0.3808 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.2317 Informative Inherited
Biological Process (BP) organophosphate catabolic process 0.004033 Informative Inherited
Biological Process (BP) nucleobase-containing compound catabolic process 0.04631 Informative Inherited
Biological Process (BP) phospholipid metabolic process 0.3653 Informative Inherited
Biological Process (BP) microtubule-based process 0.2136 Informative Inherited
Biological Process (BP) intracellular transport 0.7432 Informative Inherited
Biological Process (BP) single-organism cellular localization 0.4786 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.8293 Informative Inherited
Biological Process (BP) membrane lipid metabolic process 0.001245 Informative Inherited
Biological Process (BP) ammonium ion metabolic process 0.006053 Informative Inherited
Biological Process (BP) secondary metabolic process 0.3291 Informative Inherited
Biological Process (BP) response to metal ion 0.9483 Informative Inherited
Biological Process (BP) metal ion transport 0.5685 Informative Inherited
Biological Process (BP) embryo development 0.5179 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.01537 Informative Inherited
Biological Process (BP) nuclear division 0.000000000000007296 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 0.00000000001209 Highly Informative Direct
Biological Process (BP) angiogenesis 0.00000000002913 Highly Informative Direct
Biological Process (BP) ceramide metabolic process 0.00008226 Highly Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 0 Highly Informative Direct
Biological Process (BP) spermatogenesis 0.000000000000003734 Highly Informative Direct
Biological Process (BP) nucleoside triphosphate catabolic process 0.000000008548 Highly Informative Direct
Biological Process (BP) nucleotide catabolic process 0.00005586 Highly Informative Direct
Biological Process (BP) deoxyribonucleoside triphosphate metabolic process 0.00000008943 Highly Informative Direct
Biological Process (BP) deoxyribonucleotide metabolic process 0.00001757 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.00003067 Highly Informative Direct
Biological Process (BP) deoxyribose phosphate metabolic process 0.0006125 Highly Informative Direct
Biological Process (BP) biological adhesion 0.0009134 Highly Informative Direct
Biological Process (BP) regulation of transmembrane transporter activity 0.000000000001136 Highly Informative Direct
Biological Process (BP) sphingolipid biosynthetic process 0.0000002158 Highly Informative Direct
Biological Process (BP) positive regulation of transporter activity 0.00000002992 Highly Informative Direct
Biological Process (BP) positive regulation of transmembrane transport 0.0000000004294 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 0.00009053 Highly Informative Direct
Biological Process (BP) regulation of GTPase activity 0.000000003181 Highly Informative Direct
Biological Process (BP) positive regulation of ion transport 0.000000001456 Highly Informative Direct
Biological Process (BP) macromolecule methylation 0.00000000001813 Highly Informative Direct
Biological Process (BP) positive regulation of cellular component biogenesis 0.00009245 Highly Informative Direct
Biological Process (BP) single-organism behavior 0.0006932 Highly Informative Direct
Biological Process (BP) DNA methylation or demethylation 0 Highly Informative Direct
Biological Process (BP) neuron development 0.0000000000006121 Highly Informative Direct
Biological Process (BP) nervous system process 0.0001858 Highly Informative Direct
Biological Process (BP) meiotic cell cycle 0.0000000000007698 Highly Informative Direct
Biological Process (BP) negative regulation of cytoskeleton organization 0.0005209 Highly Informative Direct
Biological Process (BP) multi-organism behavior 0.0000000006668 Highly Informative Direct
Biological Process (BP) negative regulation of nervous system development 0.0001881 Highly Informative Direct
Biological Process (BP) positive regulation of nervous system development 0.0009749 Highly Informative Direct
Biological Process (BP) purine-containing compound catabolic process 0.0001224 Highly Informative Direct
Biological Process (BP) plasma membrane bounded cell projection organization 0 Highly Informative Direct
Biological Process (BP) regulation of cation transmembrane transport 0.00000000009337 Highly Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0.3769 Highly Informative Inherited
Biological Process (BP) regulation of binding 0.1382 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular protein localization 0.3693 Highly Informative Inherited
Biological Process (BP) regulation of calcium ion transport 0.1246 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 0.5212 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.003799 Highly Informative Inherited
Biological Process (BP) negative regulation of cell development 0.3142 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.03327 Highly Informative Inherited
Biological Process (BP) apoptotic process 0.008354 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.06741 Highly Informative Inherited
Biological Process (BP) regulation of response to wounding 0.1869 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 0.1666 Highly Informative Inherited
Biological Process (BP) tube morphogenesis 0.2861 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular signal transduction 0.1937 Highly Informative Inherited
Biological Process (BP) positive regulation of homeostatic process 0.08086 Highly Informative Inherited
Biological Process (BP) regulation of hemopoiesis 0.5401 Highly Informative Inherited
Biological Process (BP) innate immune response 0.2454 Highly Informative Inherited
Biological Process (BP) phenol-containing compound metabolic process 0.02767 Highly Informative Inherited
Biological Process (BP) negative regulation of supramolecular fiber organization 0.002166 Highly Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 0.01271 Highly Informative Inherited
Biological Process (BP) cell maturation 0.4601 Highly Informative Inherited
Biological Process (BP) anatomical structure maturation 0.1006 Highly Informative Inherited
Biological Process (BP) regulation of epithelial cell migration 0.05822 Highly Informative Inherited
Biological Process (BP) microtubule-based movement 0.9129 Highly Informative Inherited
Biological Process (BP) small GTPase mediated signal transduction 0.3358 Highly Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 1 Highly Informative Inherited
Biological Process (BP) glycoprotein metabolic process 0.5234 Highly Informative Inherited
Biological Process (BP) macromolecule glycosylation 0.5876 Highly Informative Inherited
Biological Process (BP) divalent inorganic cation transport 0.05245 Highly Informative Inherited
Biological Process (BP) sensory organ morphogenesis 0.2575 Highly Informative Inherited
Molecular Function (MF) binding 0.0000000000001275 Least Informative Direct
Molecular Function (MF) transferase activity 0.0000000000021 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) nucleic acid binding 0.0004638 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) molecular function regulator 0.0475 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.7181 Moderately Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 1 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 1 Moderately Informative Inherited
Molecular Function (MF) structural molecule activity 0.1257 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 1 Moderately Informative Inherited
Molecular Function (MF) transcription factor activity, sequence-specific DNA binding 0.000006639 Informative Direct
Molecular Function (MF) signal transducer activity 0 Informative Direct
Molecular Function (MF) kinase activity 0.0005994 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.0000006696 Informative Direct
Molecular Function (MF) molecular transducer activity 0.0000000009851 Informative Direct
Molecular Function (MF) receptor binding 0.1672 Informative Inherited
Molecular Function (MF) purine nucleotide binding 0.1975 Informative Inherited
Molecular Function (MF) enzyme activator activity 0.009555 Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 1 Informative Inherited
Molecular Function (MF) DNA binding 0.01527 Informative Inherited
Molecular Function (MF) protein kinase activity 0.0000001341 Highly Informative Direct
Molecular Function (MF) transmembrane signaling receptor activity 0 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0.000000000008007 Highly Informative Direct
Molecular Function (MF) GTPase regulator activity 0.00008498 Highly Informative Direct
Molecular Function (MF) transferase activity, transferring pentosyl groups 0.002994 Highly Informative Inherited
Molecular Function (MF) transcription regulatory region DNA binding 0.006562 Highly Informative Inherited
Molecular Function (MF) double-stranded DNA binding 0.8053 Highly Informative Inherited
Molecular Function (MF) sequence-specific DNA binding 1 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 0.6684 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.1315 Least Informative Inherited
Cellular Component (CC) protein complex 0.9771 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.9764 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) membrane 0.02496 Least Informative Inherited
Cellular Component (CC) intrinsic component of membrane 0.00004126 Moderately Informative Direct
Cellular Component (CC) cell projection 0.0000000292 Moderately Informative Direct
Cellular Component (CC) bounding membrane of organelle 0.0005793 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.04688 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.924 Moderately Informative Inherited
Cellular Component (CC) whole membrane 0.7784 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 0.001814 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 0.001187 Moderately Informative Inherited
Cellular Component (CC) vesicle 0.06817 Moderately Informative Inherited
Cellular Component (CC) transferase complex 0.365 Moderately Informative Inherited
Cellular Component (CC) endosome 0.00005515 Informative Direct
Cellular Component (CC) ribonucleoprotein granule 0 Informative Direct
Cellular Component (CC) apical part of cell 0.00007836 Informative Direct
Cellular Component (CC) cytoplasmic region 0.000000234 Informative Direct
Cellular Component (CC) plasma membrane bounded cell projection part 1 Informative Inherited
Cellular Component (CC) cilium 0.7364 Informative Inherited
Cellular Component (CC) plasma membrane region 0.0178 Informative Inherited
Cellular Component (CC) neuron projection 0.00163 Informative Inherited
Cellular Component (CC) cytoplasmic vesicle part 0.3415 Informative Inherited
Cellular Component (CC) ubiquitin ligase complex 0.01175 Informative Inherited
Cellular Component (CC) nuclear ubiquitin ligase complex 0.00000000311 Highly Informative Direct
Cellular Component (CC) dendrite 0.00007121 Highly Informative Direct
Cellular Component (CC) intrinsic component of plasma membrane 0.000002713 Highly Informative Direct
Cellular Component (CC) pole plasm 0 Highly Informative Direct
Cellular Component (CC) contractile ring 0.000000002367 Highly Informative Direct
Cellular Component (CC) receptor complex 0.1486 Highly Informative Inherited
Cellular Component (CC) presynapse 0.6109 Highly Informative Inherited
Cellular Component (CC) endosome membrane 0.001095 Highly Informative Inherited
Cellular Component (CC) cell-substrate adherens junction 0.3096 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0.558Least InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0.007561Moderately InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0.00471Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep1Moderately InformativeInherited
Enzyme Commission (EC)Receptor protein-tyrosine kinase0.00000000001004InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-3,4,5-trisphosphate 5-phospha0Highly InformativeDirect
Enzyme Commission (EC)Diacylglycerol kinase0Highly InformativeDirect
Enzyme Commission (EC)Mitogen-activated protein kinase kinase kinase0.0000000000009763Highly InformativeDirect
Enzyme Commission (EC)Transferases for other substituted phosphate group0.01424Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processApoptosis0Moderately InformativeDirect
Biological processDifferentiation0Moderately InformativeDirect
Biological processTranscription regulation0Moderately InformativeDirect
Biological processImmunity0.000000000001006Moderately InformativeDirect
Biological processProtein transport0.00004121Moderately InformativeDirect
Biological processLipid metabolism0.516Moderately InformativeInherited
Biological processIon transport0.8296Moderately InformativeInherited
Biological processCell adhesion0InformativeDirect
Biological processMeiosis0InformativeDirect
Biological processNeurogenesis0InformativeDirect
Biological processAngiogenesis0.0000000003174InformativeDirect
Biological processTranslation regulation0.000002578InformativeDirect
Biological processRNA-mediated gene silencing0Highly InformativeDirect
Biological processSphingolipid metabolism0.00000000000003144Highly InformativeDirect
Biological processSpermatogenesis0.00000000005981Highly InformativeDirect
Biological processCalcium transport0.0000000007738Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentMembrane0.0002148Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentEndosome0.0000000004726Moderately InformativeDirect
Cellular componentCytoskeleton0.00000003004Moderately InformativeDirect
Coding sequence diversityAlternative splicing0.000000009384Least InformativeDirect
Coding sequence diversityAlternative promoter usage0.000001614Moderately InformativeDirect
DiseaseProto-oncogene0.00008727Moderately InformativeDirect
DiseaseTumor suppressor0.0001686Moderately InformativeDirect
DomainRepeat0Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainCoiled coil0.0000000003551Moderately InformativeDirect
DomainANK repeat0InformativeDirect
DomainSH3 domain0InformativeDirect
DomainSH3-binding0.0000000002082InformativeDirect
DomainSH2 domain0.00003243InformativeDirect
Molecular functionZinc0.000224Least InformativeDirect
Post-translational modificationTransferase0.1321Least InformativeInherited
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationRepressor0Moderately InformativeDirect
Post-translational modificationDNA-binding0.000000000000006056Moderately InformativeDirect
Post-translational modificationActivator0.000004725Moderately InformativeDirect
Post-translational modificationGTPase activation0.0000000000006269InformativeDirect
Post-translational modificationChromatin regulator0.000000006835InformativeDirect
Post-translational modificationActin-binding0.0000004865InformativeDirect
Post-translational modificationTyrosine-protein kinase0Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation0.0008714Moderately InformativeDirect
Post-translational modificationHydroxylation0.0005282InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR010993 SSF47769 Protein matches
Abstract

Sterile alpha motif (SAM) domains are known to be involved in diverse protein-protein interactions, associating with both SAM-containing and non-SAM-containing proteins pathway [PubMed14659692]. SAM domains exhibit a conserved structure, consisting of a 4-5-helical bundle of two orthogonally packed alpha-hairpins. However SAM domains display a diversity of function, being involved in interactions with proteins, DNA and RNA [PubMed12858164]. The name sterile alpha motif arose from its presence in proteins that are essential for yeast sexual differentiation. The SAM domain has had various names, including SPM, PTN (pointed), SEP (yeast sterility, Ets-related, PcG proteins), NCR (N-terminal conserved region) and HLH (helix-loop-helix) domain, all of which are related and can be classified as SAM domains.

SAM domains occur in eukaryotic and in some bacterial proteins. Structures have been determined for several proteins that contain SAM domains, including Ets-1 transcription factor, which plays a role in the development and invasion of tumour cells by regulating the expression of matrix-degrading proteases [PubMed14704859]; Etv6 transcription factor, gene rearrangements of which have been demonstrated in several malignancies [PubMed9031109]; EphA4 receptor tyrosine kinase, which is believed to be important for the correct localization of a motoneuron pool to a specific position in the spinal cord [PubMed12577325]; EphB2 receptor, which is involved in spine morphogenesis via intersectin, Cdc42 and N-Wasp [PubMed12389031]; p73, a p53 homologue involved in neuronal development [PubMed14659698]; and polyhomeotic, which is a member of the Polycomb group of genes (Pc-G) required for the maintenance of the spatial expression pattern of homeotic genes [PubMed14499651].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 24 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a SAM/Pointed domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 24 hidden Markov models representing the SAM/Pointed domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


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