SUPERFAMILY 1.75 HMM library and genome assignments server


Annexin superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Annexin [ 47873]
Superfamily:   Annexin [ 47874]
Families:   Annexin [ 47875] (9)


Superfamily statistics
Genomes (302) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 2,694 2,617 37
Proteins 2,552 2,472 35


Functional annotation
General category Processes_IC
Detailed category Phospholipid metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus1.991e-091.829e-05Least InformativeDirect
Biological Process (BP)localization0.00013590.0001231Least InformativeDirect
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.99481Least InformativeInherited
Biological Process (BP)single-organism cellular process1.625e-060.01759Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis6.25e-050.1733Least InformativeInherited
Biological Process (BP)multicellular organismal process4.854e-050.1299Least InformativeInherited
Biological Process (BP)developmental process2.191e-050.4617Least InformativeInherited
Biological Process (BP)positive regulation of cellular process0.00020660.08129Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.4740.6864Moderately InformativeInherited
Biological Process (BP)positive regulation of molecular function0.47330.6783Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.048070.006877Moderately InformativeInherited
Biological Process (BP)ion transport0.27370.02266Moderately InformativeInherited
Biological Process (BP)regulation of catalytic activity0.29450.06573Moderately InformativeInherited
Biological Process (BP)organic substance transport0.11360.8134Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.0060370.4068Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.36350.525Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.051660.006037Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.076360.5361Moderately InformativeInherited
Biological Process (BP)single-organism developmental process0.028441Moderately InformativeInherited
Biological Process (BP)lipid localization0.00011146.125e-05InformativeDirect
Biological Process (BP)regulation of response to external stimulus1.234e-085.985e-06InformativeDirect
Biological Process (BP)negative regulation of catalytic activity6.96e-073.484e-05InformativeDirect
Biological Process (BP)cardiovascular system development1.879e-050.0004205InformativeDirect
Biological Process (BP)regulation of cell cycle0.015260.04379InformativeInherited
Biological Process (BP)anion transport0.10180.8264InformativeInherited
Biological Process (BP)organic acid transport0.0094990.02147InformativeInherited
Biological Process (BP)response to inorganic substance0.0033421.458e-05InformativeInherited
Biological Process (BP)anatomical structure formation involved in morphogenesis0.00027080.004992InformativeInherited
Biological Process (BP)response to acid2.429e-071.666e-07Highly InformativeDirect
Biological Process (BP)angiogenesis2.075e-081.883e-08Highly InformativeDirect
Biological Process (BP)response to osmotic stress2.916e-071.285e-12Highly InformativeDirect
Biological Process (BP)response to heat1.415e-082.168e-06Highly InformativeDirect
Biological Process (BP)response to cold7.562e-104.218e-07Highly InformativeDirect
Biological Process (BP)response to water deprivation4.99e-114.309e-09Highly InformativeDirect
Biological Process (BP)monocarboxylic acid transport2.514e-082.984e-07Highly InformativeDirect
Biological Process (BP)extracellular matrix organization7.008e-123.72e-07Highly InformativeDirect
Biological Process (BP)regulation of coagulation7.19e-142.029e-10Highly InformativeDirect
Biological Process (BP)regulation of binding9.889e-062.369e-05Highly InformativeDirect
Biological Process (BP)negative regulation of multicellular organismal process8.343e-073.819e-05Highly InformativeDirect
Biological Process (BP)regulation of wound healing02.357e-12Highly InformativeDirect
Biological Process (BP)positive regulation of cell cycle process0.00022636.5e-05Highly InformativeDirect
Biological Process (BP)regulation of hemostasis2.926e-141.173e-10Highly InformativeDirect
Biological Process (BP)regulation of G1/S transition of mitotic cell cycle5.443e-093.347e-07Highly InformativeDirect
Molecular Function (MF)binding3.397e-131.971e-10Least InformativeDirect
Molecular Function (MF)anion binding1.196e-051.847e-05Moderately InformativeDirect
Molecular Function (MF)cation binding11Moderately InformativeInherited
Molecular Function (MF)enzyme regulator activity0.000130.003805Moderately InformativeInherited
Molecular Function (MF)enzyme inhibitor activity1.33e-061.125e-06InformativeDirect
Molecular Function (MF)lipid binding8.577e-130InformativeDirect
Molecular Function (MF)carboxylic acid binding0.12110.04815InformativeInherited
Molecular Function (MF)cytoskeletal protein binding0.016280.1238InformativeInherited
Molecular Function (MF)calcium ion binding4.896e-069.693e-10Highly InformativeDirect
Molecular Function (MF)amino acid binding9.947e-092.851e-10Highly InformativeDirect
Cellular Component (CC)membrane5.888e-082.55e-05Least InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle0.50321Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.057020.0002033Least InformativeInherited
Cellular Component (CC)extracellular region part0.00018450.0003548Moderately InformativeDirect
Cellular Component (CC)plasma membrane part0.00011970.03197Moderately InformativeInherited
Cellular Component (CC)endosome5.558e-083.057e-06InformativeDirect
Cellular Component (CC)extracellular membrane-bounded organelle0.000411.172e-06InformativeDirect
Cellular Component (CC)extrinsic to plasma membrane5.488e-073.863e-08Highly InformativeDirect
Cellular Component (CC)sarcolemma03.48e-13Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 1.829e-05 Least Informative Direct
Biological Process (BP) localization 0.0001231 Least Informative Direct
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.01759 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.1733 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.1299 Least Informative Inherited
Biological Process (BP) developmental process 0.4617 Least Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.08129 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.6864 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.6783 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.006877 Moderately Informative Inherited
Biological Process (BP) ion transport 0.02266 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.06573 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.1693 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.5576 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.8134 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.4068 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.04112 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.525 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.006037 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.5361 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) response to inorganic substance 1.458e-05 Informative Direct
Biological Process (BP) lipid localization 6.125e-05 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.0008622 Informative Direct
Biological Process (BP) metal ion transport 2.237e-06 Informative Direct
Biological Process (BP) regulation of response to external stimulus 5.985e-06 Informative Direct
Biological Process (BP) negative regulation of catalytic activity 3.484e-05 Informative Direct
Biological Process (BP) regulation of body fluid levels 1.07e-05 Informative Direct
Biological Process (BP) cation homeostasis 9.117e-06 Informative Direct
Biological Process (BP) cellular chemical homeostasis 8.51e-06 Informative Direct
Biological Process (BP) cardiovascular system development 0.0004205 Informative Direct
Biological Process (BP) regulation of cell cycle 0.04379 Informative Inherited
Biological Process (BP) anion transport 0.8264 Informative Inherited
Biological Process (BP) organic acid transport 0.02147 Informative Inherited
Biological Process (BP) regulation of system process 0.01065 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.004992 Informative Inherited
Biological Process (BP) response to acid 1.666e-07 Highly Informative Direct
Biological Process (BP) angiogenesis 1.883e-08 Highly Informative Direct
Biological Process (BP) calcium ion transport 1.373e-09 Highly Informative Direct
Biological Process (BP) cellular calcium ion homeostasis 2.692e-07 Highly Informative Direct
Biological Process (BP) regulation of muscle contraction 2.398e-11 Highly Informative Direct
Biological Process (BP) response to osmotic stress 1.285e-12 Highly Informative Direct
Biological Process (BP) response to heat 2.168e-06 Highly Informative Direct
Biological Process (BP) response to cold 4.218e-07 Highly Informative Direct
Biological Process (BP) response to water deprivation 4.309e-09 Highly Informative Direct
Biological Process (BP) monocarboxylic acid transport 2.984e-07 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 3.72e-07 Highly Informative Direct
Biological Process (BP) regulation of coagulation 2.029e-10 Highly Informative Direct
Biological Process (BP) regulation of binding 2.369e-05 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 3.819e-05 Highly Informative Direct
Biological Process (BP) regulation of wound healing 2.357e-12 Highly Informative Direct
Biological Process (BP) positive regulation of cell cycle process 6.5e-05 Highly Informative Direct
Biological Process (BP) regulation of hemostasis 1.173e-10 Highly Informative Direct
Biological Process (BP) regulation of G1/S transition of mitotic cell cycle 3.347e-07 Highly Informative Direct
Molecular Function (MF) binding 1.971e-10 Least Informative Direct
Molecular Function (MF) anion binding 1.847e-05 Moderately Informative Direct
Molecular Function (MF) cation binding 1 Moderately Informative Inherited
Molecular Function (MF) enzyme regulator activity 0.003805 Moderately Informative Inherited
Molecular Function (MF) enzyme inhibitor activity 1.125e-06 Informative Direct
Molecular Function (MF) lipid binding 0 Informative Direct
Molecular Function (MF) carboxylic acid binding 0.04815 Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0.1238 Informative Inherited
Molecular Function (MF) calcium ion binding 9.693e-10 Highly Informative Direct
Molecular Function (MF) amino acid binding 2.851e-10 Highly Informative Direct
Cellular Component (CC) membrane 2.55e-05 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.0002033 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) endomembrane system 0.0004164 Moderately Informative Direct
Cellular Component (CC) vesicle 2.166e-09 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.0003548 Moderately Informative Direct
Cellular Component (CC) plasma membrane part 0.03197 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 0.002271 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.3035 Moderately Informative Inherited
Cellular Component (CC) nuclear envelope 4.953e-07 Informative Direct
Cellular Component (CC) endosome 3.057e-06 Informative Direct
Cellular Component (CC) extracellular membrane-bounded organelle 1.172e-06 Informative Direct
Cellular Component (CC) extrinsic to plasma membrane 3.863e-08 Highly Informative Direct
Cellular Component (CC) midbody 2.366e-06 Highly Informative Direct
Cellular Component (CC) sarcolemma 3.48e-13 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 2.245e-06 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)musculoskeletal system disease0.02373Moderately InformativeInherited

Document: DO annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Moderately InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect
Worm Phenotype (WP)germ cell morphology variant7.938e-05Moderately InformativeDirect
Worm Phenotype (WP)brood size variant0.0002426InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processHemostasis0InformativeDirect
Biological processBlood coagulation0Highly InformativeDirect
Cellular componentNucleus0.0001112Least InformativeDirect
Cellular componentCytoplasm0.4603Least InformativeInherited
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentCytoskeleton5.837e-10Moderately InformativeDirect
Cellular componentSecreted0.002176Moderately InformativeInherited
Cellular componentExtracellular matrix0InformativeDirect
Cellular componentMicrotubule4.425e-10InformativeDirect
Cellular componentBasement membrane0Highly InformativeDirect
Cellular componentCilium0Highly InformativeDirect
DomainRepeat0Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Post-translational modificationAcetylation0Least InformativeDirect
Post-translational modificationPhosphoprotein0.0009201Least InformativeDirect
Post-translational modificationIsopeptide bond6.091e-09Moderately InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR001464 SSF47874 Protein matches
Abstract


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 16 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Annexin domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 16 hidden Markov models representing the Annexin superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]