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Annexin superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Annexin [ 47873]
Superfamily:   Annexin [ 47874]
Families:   Annexin [ 47875] (9)


Superfamily statistics
Genomes (347) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 3,071 3,553 37
Proteins 2,910 3,372 35


Functional annotation
General category Processes_IC
Detailed category Phospholipid metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)localization0.000023490.000004311Least InformativeDirect
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.99161Least InformativeInherited
Biological Process (BP)single-organism cellular process0.000004910.006785Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.00041890.1888Least InformativeInherited
Biological Process (BP)response to stimulus0.0012020.04534Least InformativeInherited
Biological Process (BP)multicellular organismal process0.0010130.2223Least InformativeInherited
Biological Process (BP)developmental process0.00015310.4732Least InformativeInherited
Biological Process (BP)positive regulation of cellular process0.00016170.3049Moderately InformativeInherited
Biological Process (BP)positive regulation of molecular function0.50240.7555Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.011340.003048Moderately InformativeInherited
Biological Process (BP)ion transport0.061950.0003676Moderately InformativeInherited
Biological Process (BP)regulation of catalytic activity0.37360.1954Moderately InformativeInherited
Biological Process (BP)organic substance transport0.30231Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.028920.6931Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.0072850.02494Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.0052240.0002947Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.080270.4406Moderately InformativeInherited
Biological Process (BP)response to inorganic substance0.0000027320.0000004378InformativeDirect
Biological Process (BP)lipid localization0.0001080.00005774InformativeDirect
Biological Process (BP)metal ion transport0.00039240.0000000001236InformativeDirect
Biological Process (BP)regulation of response to external stimulus0.000000055140.00001911InformativeDirect
Biological Process (BP)negative regulation of catalytic activity0.000022360.000519InformativeDirect
Biological Process (BP)cardiovascular system development0.000018240.0009429InformativeDirect
Biological Process (BP)regulation of cell cycle process0.000048080.01042InformativeInherited
Biological Process (BP)regulation of mitotic cell cycle0.000020770.003197InformativeInherited
Biological Process (BP)anion transport0.68311InformativeInherited
Biological Process (BP)organic acid transport0.018640.03988InformativeInherited
Biological Process (BP)anatomical structure formation involved in morphogenesis0.00029520.01109InformativeInherited
Biological Process (BP)angiogenesis0.0000000070180.00000004758Highly InformativeDirect
Biological Process (BP)calcium ion transport0.0000039670Highly InformativeDirect
Biological Process (BP)response to heat0.0000000049110.000001235Highly InformativeDirect
Biological Process (BP)response to cold0.00000000015390.0000001817Highly InformativeDirect
Biological Process (BP)response to water deprivation0.0000000000086010.000000001646Highly InformativeDirect
Biological Process (BP)response to salt stress0.00000000071260.000000000000001938Highly InformativeDirect
Biological Process (BP)monocarboxylic acid transport0.000000049330.000000566Highly InformativeDirect
Biological Process (BP)regulation of coagulation0.00000000000033730.0000000003965Highly InformativeDirect
Biological Process (BP)regulation of binding0.0000053740.0000188Highly InformativeDirect
Biological Process (BP)negative regulation of multicellular organismal process0.00000032740.00003487Highly InformativeDirect
Biological Process (BP)regulation of wound healing0.0000000000000016880.00000000001109Highly InformativeDirect
Biological Process (BP)positive regulation of cell cycle process0.00011170.00004938Highly InformativeDirect
Biological Process (BP)regulation of hemostasis0.00000000000014010.0000000002379Highly InformativeDirect
Biological Process (BP)regulation of G1/S transition of mitotic cell cycle0.000000017840.000000829Highly InformativeDirect
Biological Process (BP)extracellular matrix organization10.0000008229Highly InformativeInherited
Molecular Function (MF)binding0.00000000027260.00000001724Least InformativeDirect
Molecular Function (MF)anion binding0.000005580.000005669Moderately InformativeDirect
Molecular Function (MF)transporter activity0.20340.04364Moderately InformativeInherited
Molecular Function (MF)cation binding11Moderately InformativeInherited
Molecular Function (MF)enzyme regulator activity0.0018980.02542Moderately InformativeInherited
Molecular Function (MF)enzyme inhibitor activity0.000046660.00003353InformativeDirect
Molecular Function (MF)lipid binding0.0000000000079150InformativeDirect
Molecular Function (MF)metal ion transmembrane transporter activity0.00017470.0001378InformativeDirect
Molecular Function (MF)carbohydrate derivative binding0.00018130.000008269InformativeDirect
Molecular Function (MF)sulfur compound binding0.00013030.000002061InformativeDirect
Molecular Function (MF)inorganic cation transmembrane transporter activity0.0042320.0009409InformativeInherited
Molecular Function (MF)carboxylic acid binding0.13130.06585InformativeInherited
Molecular Function (MF)cytoskeletal protein binding0.068890.07909InformativeInherited
Molecular Function (MF)calcium ion binding0.000010890.000000003648Highly InformativeDirect
Molecular Function (MF)calcium ion transmembrane transporter activity0.00000029930.000000611Highly InformativeDirect
Molecular Function (MF)amino acid binding0.000000021060.0000000007923Highly InformativeDirect
Molecular Function (MF)cation channel activity0.0000029820.003298Highly InformativeInherited
Cellular Component (CC)membrane0.000000000031230.00000001033Least InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle0.56590.8349Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.44130.004813Least InformativeInherited
Cellular Component (CC)plasma membrane0.0000000012350.00000000323Moderately InformativeDirect
Cellular Component (CC)vesicle0.000029420.0000000000002337Moderately InformativeDirect
Cellular Component (CC)extracellular region part0.000061420.0005777Moderately InformativeDirect
Cellular Component (CC)endosome0.000000010850.0000001314InformativeDirect
Cellular Component (CC)extracellular membrane-bounded organelle0.00021890.000007541InformativeDirect
Cellular Component (CC)extrinsic to plasma membrane0.0000015110.00000009588Highly InformativeDirect
Cellular Component (CC)sarcolemma00.0000000000053Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) localization 0.000004311 Least Informative Direct
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.1888 Least Informative Inherited
Biological Process (BP) response to stimulus 0.04534 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.006785 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.2223 Least Informative Inherited
Biological Process (BP) developmental process 0.4732 Least Informative Inherited
Biological Process (BP) ion transport 0.0003676 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 0.0002947 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.3049 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.7555 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.151 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.003048 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.1954 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.3097 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.6931 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.02494 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.5837 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.4406 Moderately Informative Inherited
Biological Process (BP) response to inorganic substance 0.0000004378 Informative Direct
Biological Process (BP) lipid localization 0.00005774 Informative Direct
Biological Process (BP) metal ion transport 0.0000000001236 Informative Direct
Biological Process (BP) regulation of response to external stimulus 0.00001911 Informative Direct
Biological Process (BP) negative regulation of catalytic activity 0.000519 Informative Direct
Biological Process (BP) regulation of body fluid levels 0.00002105 Informative Direct
Biological Process (BP) cation homeostasis 0.00000007663 Informative Direct
Biological Process (BP) cardiovascular system development 0.0009429 Informative Direct
Biological Process (BP) regulation of cell cycle process 0.01042 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.003197 Informative Inherited
Biological Process (BP) anion transport 1 Informative Inherited
Biological Process (BP) organic acid transport 0.03988 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.002097 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 0.09631 Informative Inherited
Biological Process (BP) regulation of system process 0.01754 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.01109 Informative Inherited
Biological Process (BP) angiogenesis 0.00000004758 Highly Informative Direct
Biological Process (BP) calcium ion transport 0 Highly Informative Direct
Biological Process (BP) regulation of muscle contraction 0.00000000005989 Highly Informative Direct
Biological Process (BP) response to heat 0.000001235 Highly Informative Direct
Biological Process (BP) response to cold 0.0000001817 Highly Informative Direct
Biological Process (BP) response to water deprivation 0.000000001646 Highly Informative Direct
Biological Process (BP) response to salt stress 0.000000000000001938 Highly Informative Direct
Biological Process (BP) monocarboxylic acid transport 0.000000566 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0.0000008229 Highly Informative Direct
Biological Process (BP) regulation of coagulation 0.0000000003965 Highly Informative Direct
Biological Process (BP) regulation of binding 0.0000188 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.00003487 Highly Informative Direct
Biological Process (BP) regulation of wound healing 0.00000000001109 Highly Informative Direct
Biological Process (BP) positive regulation of cell cycle process 0.00004938 Highly Informative Direct
Biological Process (BP) regulation of hemostasis 0.0000000002379 Highly Informative Direct
Biological Process (BP) regulation of G1/S transition of mitotic cell cycle 0.000000829 Highly Informative Direct
Molecular Function (MF) binding 0.00000001724 Least Informative Direct
Molecular Function (MF) anion binding 0.000005669 Moderately Informative Direct
Molecular Function (MF) transporter activity 0.04364 Moderately Informative Inherited
Molecular Function (MF) cation binding 1 Moderately Informative Inherited
Molecular Function (MF) enzyme regulator activity 0.02542 Moderately Informative Inherited
Molecular Function (MF) enzyme inhibitor activity 0.00003353 Informative Direct
Molecular Function (MF) lipid binding 0 Informative Direct
Molecular Function (MF) inorganic cation transmembrane transporter activity 0.0009409 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 0.0001378 Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.000008269 Informative Direct
Molecular Function (MF) sulfur compound binding 0.000002061 Informative Direct
Molecular Function (MF) carboxylic acid binding 0.06585 Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0.07909 Informative Inherited
Molecular Function (MF) calcium ion binding 0.000000003648 Highly Informative Direct
Molecular Function (MF) calcium ion transmembrane transporter activity 0.000000611 Highly Informative Direct
Molecular Function (MF) amino acid binding 0.0000000007923 Highly Informative Direct
Molecular Function (MF) cation channel activity 0.003298 Highly Informative Inherited
Cellular Component (CC) membrane 0.00000001033 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.004813 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.8731 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.8349 Least Informative Inherited
Cellular Component (CC) plasma membrane 0.00000000323 Moderately Informative Direct
Cellular Component (CC) endomembrane system 0.00003161 Moderately Informative Direct
Cellular Component (CC) vesicle 0.0000000000002337 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.0005777 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0.005614 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 0.00144 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.4749 Moderately Informative Inherited
Cellular Component (CC) nuclear envelope 0.0000047 Informative Direct
Cellular Component (CC) endosome 0.0000001314 Informative Direct
Cellular Component (CC) extracellular membrane-bounded organelle 0.000007541 Informative Direct
Cellular Component (CC) extrinsic to plasma membrane 0.00000009588 Highly Informative Direct
Cellular Component (CC) sarcolemma 0.0000000000053 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 0.0000009276 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)connective tissue disease0.0146Moderately InformativeInherited

Document: DO annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Moderately InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect
Worm Phenotype (WP)germ cell morphology variant0.00007938Moderately InformativeDirect
Worm Phenotype (WP)brood size variant0.0002426InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processHemostasis0InformativeDirect
Biological processBlood coagulation0Highly InformativeDirect
Cellular componentNucleus0.000143Least InformativeDirect
Cellular componentCytoplasm0.5139Least InformativeInherited
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentCytoskeleton0.0000000007372Moderately InformativeDirect
Cellular componentSecreted0.0007966Moderately InformativeDirect
Cellular componentExtracellular matrix0InformativeDirect
Cellular componentMicrotubule0.0000000004781InformativeDirect
Cellular componentBasement membrane0Highly InformativeDirect
Cellular componentCilium0Highly InformativeDirect
DomainRepeat0Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Post-translational modificationAcetylation0Least InformativeDirect
Post-translational modificationPhosphoprotein0.0005791Least InformativeDirect
Post-translational modificationIsopeptide bond0.00000001037Moderately InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR001464 SSF47874 Protein matches
Abstract


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 16 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Annexin domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 16 hidden Markov models representing the Annexin superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]