SUPERFAMILY 1.75 HMM library and genome assignments server


Annexin superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Annexin [ 47873]
Superfamily:   Annexin [ 47874]
Families:   Annexin [ 47875] (9)


Superfamily statistics
Genomes (338) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 2,948 3,553 37
Proteins 2,790 3,372 35


Functional annotation
General category Processes_IC
Detailed category Phospholipid metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus1.865e-070.0002784Least InformativeDirect
Biological Process (BP)localization1.387e-051.655e-06Least InformativeDirect
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.99771Least InformativeInherited
Biological Process (BP)single-organism cellular process1.937e-060.003245Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.00022730.1356Least InformativeInherited
Biological Process (BP)multicellular organismal process0.00022620.1121Least InformativeInherited
Biological Process (BP)developmental process9.615e-050.4039Least InformativeInherited
Biological Process (BP)positive regulation of cellular process0.00013990.2263Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.59750.7572Moderately InformativeInherited
Biological Process (BP)positive regulation of molecular function0.52490.7623Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.011090.002888Moderately InformativeInherited
Biological Process (BP)ion transport0.063610.000392Moderately InformativeInherited
Biological Process (BP)regulation of catalytic activity0.40940.1685Moderately InformativeInherited
Biological Process (BP)organic substance transport0.31281Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.02890.6899Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.29090.3682Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.043140.003434Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.075280.4373Moderately InformativeInherited
Biological Process (BP)single-organism developmental process0.077741Moderately InformativeInherited
Biological Process (BP)lipid localization0.00010895.857e-05InformativeDirect
Biological Process (BP)metal ion transport0.0003427.125e-11InformativeDirect
Biological Process (BP)regulation of response to external stimulus3.535e-081.14e-05InformativeDirect
Biological Process (BP)negative regulation of catalytic activity1.907e-050.0004012InformativeDirect
Biological Process (BP)cardiovascular system development1.821e-050.0007265InformativeDirect
Biological Process (BP)regulation of cell cycle process4.002e-050.008425InformativeInherited
Biological Process (BP)regulation of mitotic cell cycle1.715e-050.002417InformativeInherited
Biological Process (BP)regulation of response to stress1.789e-060.002561InformativeInherited
Biological Process (BP)anion transport0.67871InformativeInherited
Biological Process (BP)organic acid transport0.020330.04228InformativeInherited
Biological Process (BP)response to inorganic substance0.0020332.438e-05InformativeInherited
Biological Process (BP)anatomical structure formation involved in morphogenesis0.00025270.007947InformativeInherited
Biological Process (BP)response to acid1.391e-076.748e-08Highly InformativeDirect
Biological Process (BP)angiogenesis7.928e-093.451e-08Highly InformativeDirect
Biological Process (BP)calcium ion transport3.651e-060Highly InformativeDirect
Biological Process (BP)response to heat5.744e-091.333e-06Highly InformativeDirect
Biological Process (BP)response to cold1.88e-102.063e-07Highly InformativeDirect
Biological Process (BP)response to water deprivation1.151e-111.972e-09Highly InformativeDirect
Biological Process (BP)response to salt stress4.577e-100Highly InformativeDirect
Biological Process (BP)monocarboxylic acid transport4.217e-084.596e-07Highly InformativeDirect
Biological Process (BP)extracellular matrix organization1.574e-116.512e-07Highly InformativeDirect
Biological Process (BP)regulation of coagulation4.399e-134.724e-10Highly InformativeDirect
Biological Process (BP)regulation of binding4.662e-061.529e-05Highly InformativeDirect
Biological Process (BP)negative regulation of multicellular organismal process3.564e-073.696e-05Highly InformativeDirect
Biological Process (BP)regulation of wound healing1.707e-158.228e-12Highly InformativeDirect
Biological Process (BP)positive regulation of cell cycle process0.00011683.713e-05Highly InformativeDirect
Biological Process (BP)regulation of hemostasis1.83e-132.838e-10Highly InformativeDirect
Biological Process (BP)regulation of G1/S transition of mitotic cell cycle1.408e-086.065e-07Highly InformativeDirect
Molecular Function (MF)binding5.046e-111.994e-09Least InformativeDirect
Molecular Function (MF)anion binding7.061e-066.76e-06Moderately InformativeDirect
Molecular Function (MF)transporter activity0.190.03742Moderately InformativeInherited
Molecular Function (MF)cation binding11Moderately InformativeInherited
Molecular Function (MF)enzyme regulator activity0.001580.02099Moderately InformativeInherited
Molecular Function (MF)enzyme inhibitor activity3.804e-052.694e-05InformativeDirect
Molecular Function (MF)lipid binding1.019e-110InformativeDirect
Molecular Function (MF)metal ion transmembrane transporter activity0.00015390.0001091InformativeDirect
Molecular Function (MF)carbohydrate derivative binding0.00020179.01e-06InformativeDirect
Molecular Function (MF)sulfur compound binding0.00014512.045e-06InformativeDirect
Molecular Function (MF)inorganic cation transmembrane transporter activity0.0037170.000756InformativeInherited
Molecular Function (MF)carboxylic acid binding0.13610.06218InformativeInherited
Molecular Function (MF)cytoskeletal protein binding0.068060.07914InformativeInherited
Molecular Function (MF)actin binding3.986e-053.024e-05Highly InformativeDirect
Molecular Function (MF)calcium ion binding8.722e-062.186e-09Highly InformativeDirect
Molecular Function (MF)calcium ion transmembrane transporter activity2.684e-074.789e-07Highly InformativeDirect
Molecular Function (MF)amino acid binding1.646e-084.967e-10Highly InformativeDirect
Molecular Function (MF)cation channel activity2.677e-060.003322Highly InformativeInherited
Cellular Component (CC)membrane9.352e-133.486e-10Least InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle0.35730.6959Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.41950.003996Least InformativeInherited
Cellular Component (CC)plasma membrane2.003e-109.64e-10Moderately InformativeDirect
Cellular Component (CC)vesicle6.06e-054.273e-13Moderately InformativeDirect
Cellular Component (CC)extracellular region part0.00011320.0006884Moderately InformativeDirect
Cellular Component (CC)endosome9.36e-091.179e-07InformativeDirect
Cellular Component (CC)extracellular membrane-bounded organelle0.0004751.456e-05InformativeDirect
Cellular Component (CC)extrinsic to plasma membrane1.588e-061.017e-07Highly InformativeDirect
Cellular Component (CC)sarcolemma1.486e-158.821e-12Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0.0002784 Least Informative Direct
Biological Process (BP) localization 1.655e-06 Least Informative Direct
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.1356 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.003245 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.1121 Least Informative Inherited
Biological Process (BP) developmental process 0.4039 Least Informative Inherited
Biological Process (BP) ion transport 0.000392 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.2263 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.7572 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.7623 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.002888 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.1685 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.3052 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.6899 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.01398 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.3682 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.5742 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.003434 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.4373 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) response to inorganic substance 2.438e-05 Informative Direct
Biological Process (BP) lipid localization 5.857e-05 Informative Direct
Biological Process (BP) metal ion transport 7.125e-11 Informative Direct
Biological Process (BP) regulation of response to external stimulus 1.14e-05 Informative Direct
Biological Process (BP) negative regulation of catalytic activity 0.0004012 Informative Direct
Biological Process (BP) regulation of body fluid levels 2.75e-05 Informative Direct
Biological Process (BP) cardiovascular system development 0.0007265 Informative Direct
Biological Process (BP) regulation of cell cycle process 0.008425 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.002417 Informative Inherited
Biological Process (BP) regulation of response to stress 0.002561 Informative Inherited
Biological Process (BP) metal ion homeostasis 0.1901 Informative Inherited
Biological Process (BP) anion transport 1 Informative Inherited
Biological Process (BP) organic acid transport 0.04228 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.001529 Informative Inherited
Biological Process (BP) regulation of system process 0.01618 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.007947 Informative Inherited
Biological Process (BP) response to acid 6.748e-08 Highly Informative Direct
Biological Process (BP) angiogenesis 3.451e-08 Highly Informative Direct
Biological Process (BP) calcium ion transport 0 Highly Informative Direct
Biological Process (BP) regulation of muscle contraction 3.944e-11 Highly Informative Direct
Biological Process (BP) response to heat 1.333e-06 Highly Informative Direct
Biological Process (BP) response to cold 2.063e-07 Highly Informative Direct
Biological Process (BP) response to water deprivation 1.972e-09 Highly Informative Direct
Biological Process (BP) response to salt stress 0 Highly Informative Direct
Biological Process (BP) monocarboxylic acid transport 4.596e-07 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 6.512e-07 Highly Informative Direct
Biological Process (BP) regulation of coagulation 4.724e-10 Highly Informative Direct
Biological Process (BP) regulation of binding 1.529e-05 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 3.696e-05 Highly Informative Direct
Biological Process (BP) regulation of wound healing 8.228e-12 Highly Informative Direct
Biological Process (BP) positive regulation of cell cycle process 3.713e-05 Highly Informative Direct
Biological Process (BP) regulation of hemostasis 2.838e-10 Highly Informative Direct
Biological Process (BP) regulation of G1/S transition of mitotic cell cycle 6.065e-07 Highly Informative Direct
Molecular Function (MF) binding 1.994e-09 Least Informative Direct
Molecular Function (MF) anion binding 6.76e-06 Moderately Informative Direct
Molecular Function (MF) transporter activity 0.03742 Moderately Informative Inherited
Molecular Function (MF) cation binding 1 Moderately Informative Inherited
Molecular Function (MF) enzyme regulator activity 0.02099 Moderately Informative Inherited
Molecular Function (MF) enzyme inhibitor activity 2.694e-05 Informative Direct
Molecular Function (MF) lipid binding 0 Informative Direct
Molecular Function (MF) inorganic cation transmembrane transporter activity 0.000756 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 0.0001091 Informative Direct
Molecular Function (MF) carbohydrate derivative binding 9.01e-06 Informative Direct
Molecular Function (MF) sulfur compound binding 2.045e-06 Informative Direct
Molecular Function (MF) carboxylic acid binding 0.06218 Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0.07914 Informative Inherited
Molecular Function (MF) actin binding 3.024e-05 Highly Informative Direct
Molecular Function (MF) calcium ion binding 2.186e-09 Highly Informative Direct
Molecular Function (MF) calcium ion transmembrane transporter activity 4.789e-07 Highly Informative Direct
Molecular Function (MF) amino acid binding 4.967e-10 Highly Informative Direct
Molecular Function (MF) cation channel activity 0.003322 Highly Informative Inherited
Cellular Component (CC) membrane 3.486e-10 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.003996 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.8903 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.6959 Least Informative Inherited
Cellular Component (CC) plasma membrane 9.64e-10 Moderately Informative Direct
Cellular Component (CC) endomembrane system 1.857e-05 Moderately Informative Direct
Cellular Component (CC) vesicle 4.273e-13 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.0006884 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0.005288 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 0.001221 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.4935 Moderately Informative Inherited
Cellular Component (CC) nuclear envelope 4.685e-06 Informative Direct
Cellular Component (CC) endosome 1.179e-07 Informative Direct
Cellular Component (CC) extracellular membrane-bounded organelle 1.456e-05 Informative Direct
Cellular Component (CC) extrinsic to plasma membrane 1.017e-07 Highly Informative Direct
Cellular Component (CC) sarcolemma 8.821e-12 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 7.888e-07 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)musculoskeletal system disease0.02357Moderately InformativeInherited

Document: DO annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Moderately InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect
Worm Phenotype (WP)germ cell morphology variant7.938e-05Moderately InformativeDirect
Worm Phenotype (WP)brood size variant0.0002426InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processHemostasis0InformativeDirect
Biological processBlood coagulation0Highly InformativeDirect
Cellular componentNucleus0.000143Least InformativeDirect
Cellular componentCytoplasm0.5166Least InformativeInherited
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentCytoskeleton7.342e-10Moderately InformativeDirect
Cellular componentSecreted0.0007959Moderately InformativeDirect
Cellular componentExtracellular matrix0InformativeDirect
Cellular componentMicrotubule4.871e-10InformativeDirect
Cellular componentBasement membrane0Highly InformativeDirect
Cellular componentCilium0Highly InformativeDirect
DomainRepeat0Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Post-translational modificationAcetylation0Least InformativeDirect
Post-translational modificationPhosphoprotein0.0005765Least InformativeDirect
Post-translational modificationIsopeptide bond7.565e-09Moderately InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR001464 SSF47874 Protein matches
Abstract


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 16 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Annexin domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 16 hidden Markov models representing the Annexin superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]