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Annexin superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Annexin [ 47873]
Superfamily:   Annexin [ 47874]
Families:   Annexin [ 47875] (9)

Superfamily statistics
Genomes (354) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 3,176 0 37
Proteins 3,009 0 35

Functional annotation
General category Processes_IC
Detailed category Phospholipid metabolism and transport

Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)connective tissue disease0.01504Moderately InformativeInherited

Document: DO annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)general pace of development variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Least InformativeDirect
Worm Phenotype (WP)retarded heterochronic variations0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval growth variant0Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0.002565Least InformativeInherited
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect
Worm Phenotype (WP)germ cell morphology variant0.0001459Moderately InformativeDirect
Worm Phenotype (WP)reduced brood size0.0002276InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)tissue0.3685Least InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.0503Moderately InformativeInherited
Xenopus ANatomical entity (XAN)solid compound organ0.001586InformativeInherited
Xenopus ANatomical entity (XAN)skeletal system0.004591InformativeInherited
Xenopus ANatomical entity (XAN)bone tissue0.0009213Highly InformativeDirect
Xenopus DEvelopment stage (XDE)unspecified stage0.0004006Moderately InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processImmunity0.00000000000005459Moderately InformativeDirect
Biological processHemostasis0InformativeDirect
Biological processInflammatory response0InformativeDirect
Biological processInnate immunity0InformativeDirect
Biological processBlood coagulation0Highly InformativeDirect
Biological processAdaptive immunity0Highly InformativeDirect
Cellular componentNucleus0.0002386Least InformativeDirect
Cellular componentCytoplasm0.4849Least InformativeInherited
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.00000000000000261Moderately InformativeDirect
Cellular componentEndosome0.00000000000002082Moderately InformativeDirect
Cellular componentSecreted0.000000000006005Moderately InformativeDirect
Cellular componentCytoskeleton0.000000001754Moderately InformativeDirect
Cellular componentCilium0InformativeDirect
Cellular componentExtracellular matrix0.00000000001409InformativeDirect
Cellular componentMicrotubule0.0000000008094InformativeDirect
Cellular componentBasement membrane0Highly InformativeDirect
DomainRepeat0Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Post-translational modificationAcetylation0Least InformativeDirect
Post-translational modificationPhosphoprotein0.0000000001568Least InformativeDirect
Post-translational modificationIsopeptide bond0.000000000000001457Moderately InformativeDirect
Post-translational modificationUbl conjugation0.0000000004651Moderately InformativeDirect
Post-translational modificationS-nitrosylation0.000004488InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR001464 SSF47874 Protein matches

InterPro database

PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Disease Ontology (DO) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 16 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Browse and view proteins in genomes which have different domain combinations including a Annexin domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 16 hidden Markov models representing the Annexin superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Disease Ontology (DO) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]