SUPERFAMILY 1.75 HMM library and genome assignments server


Annexin superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Annexin [ 47873]
Superfamily:   Annexin [ 47874]
Families:   Annexin [ 47875] (9)


Superfamily statistics
Genomes (347) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 3,071 3,553 37
Proteins 2,910 3,372 35


Functional annotation
General category Processes_IC
Detailed category Phospholipid metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus3.906e-070.0005822Least InformativeDirect
Biological Process (BP)localization2.018e-053.112e-06Least InformativeDirect
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.99151Least InformativeInherited
Biological Process (BP)single-organism cellular process3.757e-060.00508Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.00035020.1685Least InformativeInherited
Biological Process (BP)multicellular organismal process0.00095080.2055Least InformativeInherited
Biological Process (BP)developmental process0.00014040.4528Least InformativeInherited
Biological Process (BP)positive regulation of cellular process0.00013830.2688Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.58770.7558Moderately InformativeInherited
Biological Process (BP)positive regulation of molecular function0.52820.7725Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.010570.002905Moderately InformativeInherited
Biological Process (BP)ion transport0.062090.0003929Moderately InformativeInherited
Biological Process (BP)regulation of catalytic activity0.3940.1844Moderately InformativeInherited
Biological Process (BP)organic substance transport0.30841Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.029160.699Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.28750.3633Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.043070.003439Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.07890.4411Moderately InformativeInherited
Biological Process (BP)lipid localization0.00011145.654e-05InformativeDirect
Biological Process (BP)metal ion transport0.00037861.111e-10InformativeDirect
Biological Process (BP)regulation of response to external stimulus4.541e-081.476e-05InformativeDirect
Biological Process (BP)negative regulation of catalytic activity2.112e-050.0004683InformativeDirect
Biological Process (BP)cardiovascular system development1.862e-050.0008836InformativeDirect
Biological Process (BP)regulation of cell cycle process4.78e-050.009743InformativeInherited
Biological Process (BP)regulation of mitotic cell cycle2.069e-050.002955InformativeInherited
Biological Process (BP)anion transport0.67661InformativeInherited
Biological Process (BP)organic acid transport0.019280.04073InformativeInherited
Biological Process (BP)response to inorganic substance0.0019212.262e-05InformativeInherited
Biological Process (BP)anatomical structure formation involved in morphogenesis0.00027070.01016InformativeInherited
Biological Process (BP)response to acid1.314e-076.693e-08Highly InformativeDirect
Biological Process (BP)angiogenesis7.406e-094.293e-08Highly InformativeDirect
Biological Process (BP)calcium ion transport4.073e-060Highly InformativeDirect
Biological Process (BP)response to heat5.427e-091.332e-06Highly InformativeDirect
Biological Process (BP)response to cold1.661e-101.94e-07Highly InformativeDirect
Biological Process (BP)response to water deprivation9.978e-121.881e-09Highly InformativeDirect
Biological Process (BP)response to salt stress5.619e-100Highly InformativeDirect
Biological Process (BP)monocarboxylic acid transport4.841e-085.335e-07Highly InformativeDirect
Biological Process (BP)extracellular matrix organization1.901e-117.879e-07Highly InformativeDirect
Biological Process (BP)regulation of coagulation4.198e-134.634e-10Highly InformativeDirect
Biological Process (BP)regulation of binding4.863e-061.773e-05Highly InformativeDirect
Biological Process (BP)negative regulation of multicellular organismal process3.431e-073.6e-05Highly InformativeDirect
Biological Process (BP)regulation of wound healing1.72e-151.073e-11Highly InformativeDirect
Biological Process (BP)positive regulation of cell cycle process0.00012224.593e-05Highly InformativeDirect
Biological Process (BP)regulation of hemostasis1.748e-132.787e-10Highly InformativeDirect
Biological Process (BP)regulation of G1/S transition of mitotic cell cycle1.747e-087.826e-07Highly InformativeDirect
Molecular Function (MF)binding1.387e-108.095e-09Least InformativeDirect
Molecular Function (MF)anion binding7.26e-066.728e-06Moderately InformativeDirect
Molecular Function (MF)transporter activity0.20070.04289Moderately InformativeInherited
Molecular Function (MF)cation binding11Moderately InformativeInherited
Molecular Function (MF)enzyme regulator activity0.0018190.02382Moderately InformativeInherited
Molecular Function (MF)enzyme inhibitor activity4.489e-053.149e-05InformativeDirect
Molecular Function (MF)lipid binding9.899e-120InformativeDirect
Molecular Function (MF)metal ion transmembrane transporter activity0.00016740.0001297InformativeDirect
Molecular Function (MF)carbohydrate derivative binding0.00019698.626e-06InformativeDirect
Molecular Function (MF)sulfur compound binding0.00014161.994e-06InformativeDirect
Molecular Function (MF)inorganic cation transmembrane transporter activity0.004130.0008918InformativeInherited
Molecular Function (MF)carboxylic acid binding0.13540.06266InformativeInherited
Molecular Function (MF)cytoskeletal protein binding0.067350.08122InformativeInherited
Molecular Function (MF)actin binding4.463e-053.961e-05Highly InformativeDirect
Molecular Function (MF)calcium ion binding1.065e-053.048e-09Highly InformativeDirect
Molecular Function (MF)calcium ion transmembrane transporter activity2.952e-075.747e-07Highly InformativeDirect
Molecular Function (MF)amino acid binding2.046e-086.353e-10Highly InformativeDirect
Molecular Function (MF)cation channel activity2.933e-060.003332Highly InformativeInherited
Cellular Component (CC)membrane1.521e-114.427e-09Least InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle0.55940.8394Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.43380.004489Least InformativeInherited
Cellular Component (CC)plasma membrane9.575e-102.696e-09Moderately InformativeDirect
Cellular Component (CC)vesicle2.882e-052.137e-13Moderately InformativeDirect
Cellular Component (CC)extracellular region part5.014e-050.0004524Moderately InformativeDirect
Cellular Component (CC)endosome9.731e-091.158e-07InformativeDirect
Cellular Component (CC)extracellular membrane-bounded organelle0.00021887.498e-06InformativeDirect
Cellular Component (CC)extrinsic to plasma membrane1.581e-069.886e-08Highly InformativeDirect
Cellular Component (CC)sarcolemma05.723e-12Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0.0005822 Least Informative Direct
Biological Process (BP) localization 3.112e-06 Least Informative Direct
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.1685 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.00508 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.2055 Least Informative Inherited
Biological Process (BP) developmental process 0.4528 Least Informative Inherited
Biological Process (BP) ion transport 0.0003929 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.2688 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.7558 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.7725 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.002905 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.1844 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.3041 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.699 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.01402 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.3633 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.5728 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.003439 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.4411 Moderately Informative Inherited
Biological Process (BP) response to inorganic substance 2.262e-05 Informative Direct
Biological Process (BP) lipid localization 5.654e-05 Informative Direct
Biological Process (BP) metal ion transport 1.111e-10 Informative Direct
Biological Process (BP) regulation of response to external stimulus 1.476e-05 Informative Direct
Biological Process (BP) negative regulation of catalytic activity 0.0004683 Informative Direct
Biological Process (BP) regulation of body fluid levels 2.188e-05 Informative Direct
Biological Process (BP) cardiovascular system development 0.0008836 Informative Direct
Biological Process (BP) regulation of cell cycle process 0.009743 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.002955 Informative Inherited
Biological Process (BP) metal ion homeostasis 0.1883 Informative Inherited
Biological Process (BP) anion transport 1 Informative Inherited
Biological Process (BP) organic acid transport 0.04073 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.001793 Informative Inherited
Biological Process (BP) regulation of system process 0.01602 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.01016 Informative Inherited
Biological Process (BP) response to acid 6.693e-08 Highly Informative Direct
Biological Process (BP) angiogenesis 4.293e-08 Highly Informative Direct
Biological Process (BP) calcium ion transport 0 Highly Informative Direct
Biological Process (BP) regulation of muscle contraction 5.479e-11 Highly Informative Direct
Biological Process (BP) response to heat 1.332e-06 Highly Informative Direct
Biological Process (BP) response to cold 1.94e-07 Highly Informative Direct
Biological Process (BP) response to water deprivation 1.881e-09 Highly Informative Direct
Biological Process (BP) response to salt stress 0 Highly Informative Direct
Biological Process (BP) monocarboxylic acid transport 5.335e-07 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 7.879e-07 Highly Informative Direct
Biological Process (BP) regulation of coagulation 4.634e-10 Highly Informative Direct
Biological Process (BP) regulation of binding 1.773e-05 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 3.6e-05 Highly Informative Direct
Biological Process (BP) regulation of wound healing 1.073e-11 Highly Informative Direct
Biological Process (BP) positive regulation of cell cycle process 4.593e-05 Highly Informative Direct
Biological Process (BP) regulation of hemostasis 2.787e-10 Highly Informative Direct
Biological Process (BP) regulation of G1/S transition of mitotic cell cycle 7.826e-07 Highly Informative Direct
Molecular Function (MF) binding 8.095e-09 Least Informative Direct
Molecular Function (MF) anion binding 6.728e-06 Moderately Informative Direct
Molecular Function (MF) transporter activity 0.04289 Moderately Informative Inherited
Molecular Function (MF) cation binding 1 Moderately Informative Inherited
Molecular Function (MF) enzyme regulator activity 0.02382 Moderately Informative Inherited
Molecular Function (MF) enzyme inhibitor activity 3.149e-05 Informative Direct
Molecular Function (MF) lipid binding 0 Informative Direct
Molecular Function (MF) inorganic cation transmembrane transporter activity 0.0008918 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 0.0001297 Informative Direct
Molecular Function (MF) carbohydrate derivative binding 8.626e-06 Informative Direct
Molecular Function (MF) sulfur compound binding 1.994e-06 Informative Direct
Molecular Function (MF) carboxylic acid binding 0.06266 Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0.08122 Informative Inherited
Molecular Function (MF) actin binding 3.961e-05 Highly Informative Direct
Molecular Function (MF) calcium ion binding 3.048e-09 Highly Informative Direct
Molecular Function (MF) calcium ion transmembrane transporter activity 5.747e-07 Highly Informative Direct
Molecular Function (MF) amino acid binding 6.353e-10 Highly Informative Direct
Molecular Function (MF) cation channel activity 0.003332 Highly Informative Inherited
Cellular Component (CC) membrane 4.427e-09 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.004489 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.881 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.8394 Least Informative Inherited
Cellular Component (CC) plasma membrane 2.696e-09 Moderately Informative Direct
Cellular Component (CC) endomembrane system 1.704e-05 Moderately Informative Direct
Cellular Component (CC) vesicle 2.137e-13 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.0004524 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0.005561 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 0.001452 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.4914 Moderately Informative Inherited
Cellular Component (CC) nuclear envelope 4.982e-06 Informative Direct
Cellular Component (CC) endosome 1.158e-07 Informative Direct
Cellular Component (CC) extracellular membrane-bounded organelle 7.498e-06 Informative Direct
Cellular Component (CC) extrinsic to plasma membrane 9.886e-08 Highly Informative Direct
Cellular Component (CC) sarcolemma 5.723e-12 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 7.71e-07 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)bone disease0.003276Moderately InformativeInherited

Document: DO annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Moderately InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect
Worm Phenotype (WP)germ cell morphology variant7.938e-05Moderately InformativeDirect
Worm Phenotype (WP)brood size variant0.0002426InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processHemostasis0InformativeDirect
Biological processBlood coagulation0Highly InformativeDirect
Cellular componentNucleus0.0001401Least InformativeDirect
Cellular componentCytoplasm0.5134Least InformativeInherited
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentCytoskeleton7.226e-10Moderately InformativeDirect
Cellular componentSecreted0.0007987Moderately InformativeDirect
Cellular componentExtracellular matrix0InformativeDirect
Cellular componentMicrotubule4.806e-10InformativeDirect
Cellular componentBasement membrane0Highly InformativeDirect
Cellular componentCilium0Highly InformativeDirect
DomainRepeat0Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Post-translational modificationAcetylation0Least InformativeDirect
Post-translational modificationPhosphoprotein0.0005645Least InformativeDirect
Post-translational modificationIsopeptide bond9.508e-09Moderately InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR001464 SSF47874 Protein matches
Abstract


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 16 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Annexin domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 16 hidden Markov models representing the Annexin superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]