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Transducin (alpha subunit), insertion domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Transducin (alpha subunit), insertion domain [ 47894]
Superfamily:   Transducin (alpha subunit), insertion domain [ 47895]
Families:   Transducin (alpha subunit), insertion domain [ 47896]


Superfamily statistics
Genomes (447) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 3,847 9,580 25
Proteins 3,807 9,487 25


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cell communication 0 Moderately Informative Direct
Biological Process (BP) single organism signaling 0 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 0.000000000000003764 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.0000000000001962 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.000001301 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.7833 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.009356 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.7052 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.8759 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.0626 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.07045 Moderately Informative Inherited
Biological Process (BP) nucleoside phosphate metabolic process 0.1391 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.788 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.9357 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.2692 Moderately Informative Inherited
Biological Process (BP) purine-containing compound metabolic process 0.05676 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.8713 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.5005 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.627 Moderately Informative Inherited
Biological Process (BP) system development 1 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 0.1116 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.03122 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 0 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0 Informative Direct
Biological Process (BP) response to radiation 0 Informative Direct
Biological Process (BP) response to nitrogen compound 0 Informative Direct
Biological Process (BP) system process 0.000001305 Informative Direct
Biological Process (BP) cellular response to lipid 0.00006711 Informative Direct
Biological Process (BP) regulation of system process 0.0005498 Informative Direct
Biological Process (BP) glycosyl compound metabolic process 0.0005666 Informative Direct
Biological Process (BP) regulation of cellular localization 0.2141 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.959 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.02697 Informative Inherited
Biological Process (BP) regulation of cell cycle 1 Informative Inherited
Biological Process (BP) actin filament-based process 0.002382 Informative Inherited
Biological Process (BP) locomotion 0.1295 Informative Inherited
Biological Process (BP) circulatory system development 0.05982 Informative Inherited
Biological Process (BP) ion homeostasis 0.4487 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 0.2649 Informative Inherited
Biological Process (BP) central nervous system development 0.02618 Informative Inherited
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 0.14 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.0115 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.9142 Informative Inherited
Biological Process (BP) supramolecular fiber organization 0.01377 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.006799 Informative Inherited
Biological Process (BP) movement of cell or subcellular component 0.3826 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.09155 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.1067 Informative Inherited
Biological Process (BP) cell activation 0.007709 Informative Inherited
Biological Process (BP) cell development 0.03431 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 0.03461 Informative Inherited
Biological Process (BP) growth 0.02831 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.1036 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) tissue development 0.2027 Informative Inherited
Biological Process (BP) embryo development 0.096 Informative Inherited
Biological Process (BP) regulation of cyclic nucleotide metabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of circadian rhythm 0 Highly Informative Direct
Biological Process (BP) cell division 0 Highly Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0.00000000000007551 Highly Informative Direct
Biological Process (BP) positive regulation of nucleotide metabolic process 0.000000000004445 Highly Informative Direct
Biological Process (BP) coagulation 0.00000006741 Highly Informative Direct
Biological Process (BP) hemostasis 0.00000007851 Highly Informative Direct
Biological Process (BP) purine ribonucleoside metabolic process 0.000005207 Highly Informative Direct
Biological Process (BP) gliogenesis 0.000007506 Highly Informative Direct
Biological Process (BP) positive regulation of cellular protein localization 0.00003598 Highly Informative Direct
Biological Process (BP) small GTPase mediated signal transduction 0.0001639 Highly Informative Direct
Biological Process (BP) wound healing 0.0001878 Highly Informative Direct
Biological Process (BP) protein folding 0.0004233 Highly Informative Direct
Biological Process (BP) regulation of microtubule-based process 0.002355 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.02607 Highly Informative Inherited
Biological Process (BP) cellular calcium ion homeostasis 0.336 Highly Informative Inherited
Biological Process (BP) actomyosin structure organization 0.02409 Highly Informative Inherited
Biological Process (BP) gastrulation 0.002773 Highly Informative Inherited
Biological Process (BP) actin filament organization 0.004888 Highly Informative Inherited
Biological Process (BP) cell growth 0.001094 Highly Informative Inherited
Biological Process (BP) developmental growth involved in morphogenesis 0.004171 Highly Informative Inherited
Biological Process (BP) neurological system process 0.003123 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 0.01288 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0 Moderately Informative Direct
Molecular Function (MF) metal ion binding 0.1563 Moderately Informative Inherited
Molecular Function (MF) purine nucleotide binding 0 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.00000000000006229 Informative Direct
Molecular Function (MF) ribonucleotide binding 0.000000000004601 Informative Direct
Molecular Function (MF) receptor binding 0.0000001753 Informative Direct
Molecular Function (MF) magnesium ion binding 0.00001062 Informative Direct
Molecular Function (MF) signal transducer activity 0.00001783 Informative Direct
Molecular Function (MF) purine nucleoside binding 0 Highly Informative Direct
Molecular Function (MF) G-protein coupled receptor binding 0 Highly Informative Direct
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) macromolecular complex 0.01681 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.8456 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) membrane protein complex 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.000000000001241 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.0000001796 Moderately Informative Direct
Cellular Component (CC) whole membrane 1 Moderately Informative Inherited
Cellular Component (CC) side of membrane 0 Informative Direct
Cellular Component (CC) plasma membrane protein complex 0 Informative Direct
Cellular Component (CC) cilium 0 Informative Direct
Cellular Component (CC) extrinsic component of membrane 0 Informative Direct
Cellular Component (CC) neuron projection 0.000000001764 Informative Direct
Cellular Component (CC) cytoplasmic region 0.000002534 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 0.000008636 Informative Direct
Cellular Component (CC) plasma membrane bounded cell projection part 0.00008503 Informative Direct
Cellular Component (CC) membrane region 0.4696 Informative Inherited
Cellular Component (CC) photoreceptor cell cilium 0 Highly Informative Direct
Cellular Component (CC) midbody 0 Highly Informative Direct
Cellular Component (CC) extrinsic component of cytoplasmic side of plasma membrane 0 Highly Informative Direct
Cellular Component (CC) GTPase complex 0 Highly Informative Direct
Cellular Component (CC) microtubule organizing center 0.0000000001212 Highly Informative Direct

Document: GO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.9606Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of forebrain morphology0.2536Moderately InformativeInherited
Phenotypic Abnormality (PA)Ectopic calcification0.005012Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.04815Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.06857Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.08075Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.1606Least InformativeInherited
Mammalian Phenotype (MP)abnormal muscle physiology0.02384Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.04012Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.08268Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.1071Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.2057Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology0.2288Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.2714Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood coagulation0.001303InformativeInherited
Mammalian Phenotype (MP)abnormal systemic arterial blood pressure0.001471InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin secretion0.001941InformativeInherited
Mammalian Phenotype (MP)impaired muscle contractility0.002483InformativeInherited
Mammalian Phenotype (MP)abnormal touch/ nociception0.007406InformativeInherited
Mammalian Phenotype (MP)abnormal vertebrae morphology0.01039InformativeInherited
Mammalian Phenotype (MP)abnormal thoracic cage morphology0.01785InformativeInherited
Mammalian Phenotype (MP)abnormal eye physiology0.04156InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel physiology0.07517InformativeInherited
Mammalian Phenotype (MP)abnormal ion homeostasis0.1391InformativeInherited
Mammalian Phenotype (MP)abnormal appendicular skeleton morphology0.1731InformativeInherited
Mammalian Phenotype (MP)decreased systemic arterial blood pressure0.000001225Highly InformativeDirect
Mammalian Phenotype (MP)decreased platelet aggregation0.000003654Highly InformativeDirect
Mammalian Phenotype (MP)abnormal rib morphology0.0002672Highly InformativeDirect
Mammalian Phenotype (MP)abnormal vascular smooth muscle physiology0.0009592Highly InformativeDirect
Mammalian Phenotype (MP)abnormal joint morphology0.001577Highly InformativeInherited
Mammalian Phenotype (MP)abnormal calcium ion homeostasis0.001748Highly InformativeInherited
Mammalian Phenotype (MP)abnormal lumbar vertebrae morphology0.002421Highly InformativeInherited
Mammalian Phenotype (MP)abnormal eye electrophysiology0.00406Highly InformativeInherited
Mammalian Phenotype (MP)abnormal mineral level0.03002Highly InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin-2 secretion0.09271Highly InformativeInherited
Mammalian Phenotype (MP)abnormal tumor necrosis factor secretion0.1564Highly InformativeInherited
Mammalian Phenotype (MP)abnormal sternum morphology0.2779Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)general pace of development variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Least InformativeDirect
Worm Phenotype (WP)retarded heterochronic variations0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval growth variant0Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.000000000000004766Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.00000000000008875Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.07126Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.4016Least InformativeInherited
Worm Phenotype (WP)cell morphology variant0.4828Least InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0Moderately InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect
Worm Phenotype (WP)movement variant0Moderately InformativeDirect
Worm Phenotype (WP)protein expression variant0.1377Moderately InformativeInherited
Worm Phenotype (WP)cell component morphology variant0.2098Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant1Moderately InformativeInherited
Worm Phenotype (WP)body posture variant0InformativeDirect
Worm Phenotype (WP)foraging behavior variant0InformativeDirect
Worm Phenotype (WP)localized movement variant0InformativeDirect
Worm Phenotype (WP)locomotor coordination variant0.0000000000006935InformativeDirect
Worm Phenotype (WP)forward locomotion variant0.00000000008327InformativeDirect
Worm Phenotype (WP)velocity of movement variant0.0000002022InformativeDirect
Worm Phenotype (WP)electrophysiology variant0.00002331InformativeDirect
Worm Phenotype (WP)aldicarb response variant0.0005951InformativeDirect
Worm Phenotype (WP)chemotaxis variant0.002332InformativeInherited
Worm Phenotype (WP)protein modification variant0.01494InformativeInherited
Worm Phenotype (WP)body width variant0.7323InformativeInherited
Worm Phenotype (WP)body length variant0.8685InformativeInherited
Worm Phenotype (WP)locomotion reduced1InformativeInherited
Worm Phenotype (WP)carbon dioxide avoidance variant0Highly InformativeDirect
Worm Phenotype (WP)coiling frequency0Highly InformativeDirect
Worm Phenotype (WP)nose movement variant0Highly InformativeDirect
Worm Phenotype (WP)amplitude of sinusoidal movement variant0Highly InformativeDirect
Worm Phenotype (WP)fat0.000000000004127Highly InformativeDirect
Worm Phenotype (WP)roaming variant0.0000000002156Highly InformativeDirect
Worm Phenotype (WP)foraging hyperactive0.0000000003272Highly InformativeDirect
Worm Phenotype (WP)drug induced gene expression variant0.000000001583Highly InformativeDirect
Worm Phenotype (WP)pausing variant0.0000001836Highly InformativeDirect
Worm Phenotype (WP)protein phosphorylation variant0.0001455Highly InformativeDirect
Worm Phenotype (WP)cytoskeleton organization biogenesis variant0.0001638Highly InformativeDirect
Worm Phenotype (WP)path curvature variant0.000289Highly InformativeDirect
Worm Phenotype (WP)backward point velocity variant0.5991Highly InformativeInherited
Worm Phenotype (WP)forward point velocity variant0.9408Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)wild-type0.0005364InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)nervous system0.1006Least InformativeInherited
Fly Anatomy (FA)somatic cell0.1569Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.1645Least InformativeInherited
Fly Anatomy (FA)anatomical group0.2844Least InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.08814Moderately InformativeInherited
Fly Anatomy (FA)neuron0.1731Moderately InformativeInherited
Fly Anatomy (FA)cell cluster organ0.2778Moderately InformativeInherited
Fly Anatomy (FA)sense organ0.3746Moderately InformativeInherited
Fly Anatomy (FA)chemosensory system0.00007771InformativeDirect
Fly Anatomy (FA)eo neuron0.0000324Highly InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system0.07209Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.187Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.2483Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical cluster0.7995Least InformativeInherited
Xenopus ANatomical entity (XAN)brain0.01308Moderately InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.1442Moderately InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.1904Moderately InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.1996Moderately InformativeInherited
Xenopus ANatomical entity (XAN)forebrain0.01227InformativeInherited
Xenopus ANatomical entity (XAN)skeletal system0.04631InformativeInherited
Xenopus ANatomical entity (XAN)animal hemisphere0.000009307Highly InformativeDirect
Xenopus ANatomical entity (XAN)dorsal marginal zone0.0003475Highly InformativeDirect
Xenopus ANatomical entity (XAN)cranium0.0006549Highly InformativeDirect
Xenopus ANatomical entity (XAN)telencephalon0.0007731Highly InformativeDirect
Xenopus ANatomical entity (XAN)olfactory system0.0186Highly InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)portion of meristem tissue0Least InformativeDirect
Plant ANatomical entity (PAN)megasporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)sporangium0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence meristem0Moderately InformativeDirect
Plant ANatomical entity (PAN)cotyledon0Moderately InformativeDirect
Plant ANatomical entity (PAN)rosette leaf0.000002288InformativeDirect
Plant ANatomical entity (PAN)fruit0.00001326InformativeDirect
Plant ANatomical entity (PAN)shoot axis stele0.0000000006626Highly InformativeDirect
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.12 twelve leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.08 eight leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.02 two leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCell cycle0.00000000007201Moderately InformativeDirect
Biological processSensory transduction0.0000000000006107InformativeDirect
Biological processVision0.0001478Highly InformativeDirect
Cellular componentMembrane0.00000002994Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentCytoskeleton0.0000000000007952Moderately InformativeDirect
Cellular componentCell membrane0.00000001194Moderately InformativeDirect
DiseaseDisease mutation0.00009011Least InformativeDirect
Molecular functionMagnesium0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionGTP-binding0InformativeDirect
Post-translational modificationPalmitate0Moderately InformativeDirect
Post-translational modificationMyristate0InformativeDirect
Post-translational modificationADP-ribosylation9.536e-16InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR011025 SSF47895 Protein matches
Abstract

Guanine nucleotide binding proteins (G proteins) are membrane-associated, heterotrimeric proteins composed of three subunits: alpha , beta and gamma [PubMed15119945]. G proteins act as signal transducers, relaying a signal from a ligand-activated GPCR (G protein-coupled receptor) to an enzyme or ion channel effector. The activated GPCR promotes the exchange of GDP for GTP on the G protein alpha subunit, allowing the trimeric G protein to be released from the receptor and to dissociate into active (GTP-bound) alpha subunit and beta/gamma dimer, both of which activate distinct downstream effectors. There are several isoforms of each subunit, which together can makeup hundreds of combinations of G proteins, each one linking a specific receptor to a certain effector.

The heterotrimeric G protein alpha subunit is composed of two domains: a GTP-binding domain and a helical insertion domain. The GTP-binding domain is homologous to Ras-like small GTPases, and includes switch regions I and II, which change conformation during activation. The helical insertion domain is inserted into the GTP-binding domain before switch region I, and is unique to heterotrimeric G proteins. This helical insertion domain functions to sequester the guanine nucleotide at the interface with the GTP-binding domain and must be displaced to enable nucleotide dissociation [PubMed12517447]. This entry represents the G protein alpha subunit helical insertion domain.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 6 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Transducin (alpha subunit), insertion domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 6 hidden Markov models representing the Transducin (alpha subunit), insertion domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]