SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.


Transducin (alpha subunit), insertion domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Transducin (alpha subunit), insertion domain [ 47894]
Superfamily:   Transducin (alpha subunit), insertion domain [ 47895]
Families:   Transducin (alpha subunit), insertion domain [ 47896]


Superfamily statistics
Genomes (449) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 3,875 11,171 25
Proteins 3,834 11,072 25


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.04751Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.06836Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.08045Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.1603Least InformativeInherited
Mammalian Phenotype (MP)abnormal muscle physiology0.0237Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.0401Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.08204Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.1071Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.2057Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology0.2265Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.2706Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood coagulation0.001282InformativeInherited
Mammalian Phenotype (MP)abnormal systemic arterial blood pressure0.001458InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin secretion0.001906InformativeInherited
Mammalian Phenotype (MP)impaired muscle contractility0.002488InformativeInherited
Mammalian Phenotype (MP)abnormal touch/ nociception0.00746InformativeInherited
Mammalian Phenotype (MP)abnormal vertebrae morphology0.01025InformativeInherited
Mammalian Phenotype (MP)abnormal thoracic cage morphology0.01747InformativeInherited
Mammalian Phenotype (MP)abnormal eye physiology0.04138InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel physiology0.0754InformativeInherited
Mammalian Phenotype (MP)abnormal ion homeostasis0.1386InformativeInherited
Mammalian Phenotype (MP)abnormal appendicular skeleton morphology0.1731InformativeInherited
Mammalian Phenotype (MP)decreased systemic arterial blood pressure0.000001231Highly InformativeDirect
Mammalian Phenotype (MP)decreased platelet aggregation0.000003415Highly InformativeDirect
Mammalian Phenotype (MP)abnormal rib morphology0.0002587Highly InformativeDirect
Mammalian Phenotype (MP)abnormal vascular smooth muscle physiology0.00094Highly InformativeDirect
Mammalian Phenotype (MP)abnormal joint morphology0.001552Highly InformativeInherited
Mammalian Phenotype (MP)abnormal calcium ion homeostasis0.001668Highly InformativeInherited
Mammalian Phenotype (MP)abnormal lumbar vertebrae morphology0.002374Highly InformativeInherited
Mammalian Phenotype (MP)abnormal eye electrophysiology0.004Highly InformativeInherited
Mammalian Phenotype (MP)abnormal mineral level0.02988Highly InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin-2 secretion0.09379Highly InformativeInherited
Mammalian Phenotype (MP)abnormal tumor necrosis factor secretion0.1559Highly InformativeInherited
Mammalian Phenotype (MP)abnormal sternum morphology0.2826Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)general pace of development variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Least InformativeDirect
Worm Phenotype (WP)retarded heterochronic variations0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval growth variant0Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.00000000000002911Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.0000000000001002Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.0821Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.4084Least InformativeInherited
Worm Phenotype (WP)cell morphology variant0.5007Least InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0Moderately InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect
Worm Phenotype (WP)movement variant0Moderately InformativeDirect
Worm Phenotype (WP)protein expression variant0.1579Moderately InformativeInherited
Worm Phenotype (WP)cell component morphology variant0.2175Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant1Moderately InformativeInherited
Worm Phenotype (WP)body posture variant0InformativeDirect
Worm Phenotype (WP)foraging behavior variant0InformativeDirect
Worm Phenotype (WP)localized movement variant0InformativeDirect
Worm Phenotype (WP)locomotor coordination variant0.0000000000006991InformativeDirect
Worm Phenotype (WP)forward locomotion variant0.0000000000811InformativeDirect
Worm Phenotype (WP)velocity of movement variant0.0000001982InformativeDirect
Worm Phenotype (WP)electrophysiology variant0.00002864InformativeDirect
Worm Phenotype (WP)aldicarb response variant0.0006113InformativeDirect
Worm Phenotype (WP)chemotaxis variant0.002367InformativeInherited
Worm Phenotype (WP)protein modification variant0.01369InformativeInherited
Worm Phenotype (WP)organelle organization biogenesis variant0.03018InformativeInherited
Worm Phenotype (WP)body width variant0.7303InformativeInherited
Worm Phenotype (WP)body length variant0.8643InformativeInherited
Worm Phenotype (WP)locomotion reduced1InformativeInherited
Worm Phenotype (WP)carbon dioxide avoidance variant0Highly InformativeDirect
Worm Phenotype (WP)coiling frequency0Highly InformativeDirect
Worm Phenotype (WP)nose movement variant0Highly InformativeDirect
Worm Phenotype (WP)amplitude of sinusoidal movement variant0Highly InformativeDirect
Worm Phenotype (WP)fat0.000000000003926Highly InformativeDirect
Worm Phenotype (WP)roaming variant0.0000000001837Highly InformativeDirect
Worm Phenotype (WP)foraging hyperactive0.0000000002519Highly InformativeDirect
Worm Phenotype (WP)drug induced gene expression variant0.000000001563Highly InformativeDirect
Worm Phenotype (WP)pausing variant0.0000001804Highly InformativeDirect
Worm Phenotype (WP)protein phosphorylation variant0.0001453Highly InformativeDirect
Worm Phenotype (WP)cytoskeleton organization biogenesis variant0.0001699Highly InformativeDirect
Worm Phenotype (WP)path curvature variant0.0002831Highly InformativeDirect
Worm Phenotype (WP)backward point velocity variant0.5997Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)wild-type0.000521InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)nervous system0.09781Least InformativeInherited
Fly Anatomy (FA)somatic cell0.1621Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.1692Least InformativeInherited
Fly Anatomy (FA)anatomical group0.2789Least InformativeInherited
Fly Anatomy (FA)sensory neuron0.07543Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.09462Moderately InformativeInherited
Fly Anatomy (FA)cell cluster organ0.2693Moderately InformativeInherited
Fly Anatomy (FA)sense organ0.3671Moderately InformativeInherited
Fly Anatomy (FA)chemosensory system0.00008091InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system0.1583Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.1877Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.2099Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.2918Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.3612Least InformativeInherited
Xenopus ANatomical entity (XAN)sensory system0.002543Moderately InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.01114Moderately InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.177Moderately InformativeInherited
Xenopus ANatomical entity (XAN)brain0.1823Moderately InformativeInherited
Xenopus ANatomical entity (XAN)epithelium0.008502InformativeInherited
Xenopus ANatomical entity (XAN)animal hemisphere0.00002147Highly InformativeDirect
Xenopus ANatomical entity (XAN)dorsal marginal zone0.0005545Highly InformativeDirect
Xenopus ANatomical entity (XAN)neuron0.0006869Highly InformativeDirect
Xenopus ANatomical entity (XAN)forebrain0.02726Highly InformativeInherited
Xenopus DEvelopment stage (XDE)post-embryonic stage0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)portion of meristem tissue0Least InformativeDirect
Plant ANatomical entity (PAN)megasporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)sporangium0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence meristem0Moderately InformativeDirect
Plant ANatomical entity (PAN)cotyledon0Moderately InformativeDirect
Plant ANatomical entity (PAN)rosette leaf0.000002288InformativeDirect
Plant ANatomical entity (PAN)fruit0.00001326InformativeDirect
Plant ANatomical entity (PAN)shoot axis stele0.0000000006626Highly InformativeDirect
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.12 twelve leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.08 eight leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.02 two leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

InterPro annotation
Cross references IPR011025 SSF47895 Protein matches
Abstract

Guanine nucleotide binding proteins (G proteins) are membrane-associated, heterotrimeric proteins composed of three subunits: alpha , beta and gamma [PubMed15119945]. G proteins act as signal transducers, relaying a signal from a ligand-activated GPCR (G protein-coupled receptor) to an enzyme or ion channel effector. The activated GPCR promotes the exchange of GDP for GTP on the G protein alpha subunit, allowing the trimeric G protein to be released from the receptor and to dissociate into active (GTP-bound) alpha subunit and beta/gamma dimer, both of which activate distinct downstream effectors. There are several isoforms of each subunit, which together can makeup hundreds of combinations of G proteins, each one linking a specific receptor to a certain effector.

The heterotrimeric G protein alpha subunit is composed of two domains: a GTP-binding domain and a helical insertion domain. The GTP-binding domain is homologous to Ras-like small GTPases, and includes switch regions I and II, which change conformation during activation. The helical insertion domain is inserted into the GTP-binding domain before switch region I, and is unique to heterotrimeric G proteins. This helical insertion domain functions to sequester the guanine nucleotide at the interface with the GTP-binding domain and must be displaced to enable nucleotide dissociation [PubMed12517447]. This entry represents the G protein alpha subunit helical insertion domain.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 6 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Transducin (alpha subunit), insertion domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 6 hidden Markov models representing the Transducin (alpha subunit), insertion domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Internal database links ]