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Transducin (alpha subunit), insertion domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Transducin (alpha subunit), insertion domain [ 47894]
Superfamily:   Transducin (alpha subunit), insertion domain [ 47895]
Families:   Transducin (alpha subunit), insertion domain [ 47896]


Superfamily statistics
Genomes (442) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 3,793 4,305 25
Proteins 3,754 4,275 25


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) response to abiotic stimulus 0 Moderately Informative Direct
Biological Process (BP) cell communication 0 Moderately Informative Direct
Biological Process (BP) signaling 0 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.0000000000001571 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.000001199 Moderately Informative Direct
Biological Process (BP) glycosyl compound metabolic process 0.03879 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.00154 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.07851 Moderately Informative Inherited
Biological Process (BP) purine-containing compound metabolic process 0.0553 Moderately Informative Inherited
Biological Process (BP) ribose phosphate metabolic process 0.0392 Moderately Informative Inherited
Biological Process (BP) nucleoside phosphate metabolic process 0.1294 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.1744 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.8591 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.871 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.1894 Moderately Informative Inherited
Biological Process (BP) system development 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 0.7367 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to stress 1 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.01733 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.01036 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.2994 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 0.7753 Moderately Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0 Informative Direct
Biological Process (BP) response to radiation 0 Informative Direct
Biological Process (BP) response to nitrogen compound 0 Informative Direct
Biological Process (BP) system process 0.00003219 Informative Direct
Biological Process (BP) cellular response to lipid 0.0001057 Informative Direct
Biological Process (BP) response to organic cyclic compound 1 Informative Inherited
Biological Process (BP) epithelium development 0.01193 Informative Inherited
Biological Process (BP) locomotion 0.113 Informative Inherited
Biological Process (BP) circulatory system development 0.06104 Informative Inherited
Biological Process (BP) embryo development 0.09364 Informative Inherited
Biological Process (BP) ion homeostasis 0.3513 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 0.1661 Informative Inherited
Biological Process (BP) central nervous system development 0.0254 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.08845 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.1321 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.03808 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.8241 Informative Inherited
Biological Process (BP) movement of cell or subcellular component 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.06896 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.1538 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0.0539 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.04758 Informative Inherited
Biological Process (BP) actin filament-based process 0.1552 Informative Inherited
Biological Process (BP) cell development 0.0203 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 0.0359 Informative Inherited
Biological Process (BP) growth 0.01294 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.09789 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.008249 Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 0 Highly Informative Direct
Biological Process (BP) regulation of cyclic nucleotide metabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of circadian rhythm 0 Highly Informative Direct
Biological Process (BP) detection of stimulus 0 Highly Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0.00000000000003395 Highly Informative Direct
Biological Process (BP) positive regulation of nucleotide metabolic process 0.000000000006377 Highly Informative Direct
Biological Process (BP) cell division 0.0000000001127 Highly Informative Direct
Biological Process (BP) guanosine-containing compound metabolic process 0.00000005379 Highly Informative Direct
Biological Process (BP) hemostasis 0.00000007771 Highly Informative Direct
Biological Process (BP) coagulation 0.0000001022 Highly Informative Direct
Biological Process (BP) gliogenesis 0.000001563 Highly Informative Direct
Biological Process (BP) actin filament organization 0.0001574 Highly Informative Direct
Biological Process (BP) wound healing 0.0001833 Highly Informative Direct
Biological Process (BP) small GTPase mediated signal transduction 0.0003161 Highly Informative Direct
Biological Process (BP) protein folding 0.0003576 Highly Informative Direct
Biological Process (BP) response to nutrient levels 0.0007132 Highly Informative Direct
Biological Process (BP) cell migration 0.08465 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.0402 Highly Informative Inherited
Biological Process (BP) cellular calcium ion homeostasis 0.4701 Highly Informative Inherited
Biological Process (BP) sensory perception 0.09334 Highly Informative Inherited
Biological Process (BP) endocytosis 0.03049 Highly Informative Inherited
Biological Process (BP) actomyosin structure organization 0.02135 Highly Informative Inherited
Biological Process (BP) gastrulation 0.002764 Highly Informative Inherited
Biological Process (BP) developmental growth involved in morphogenesis 0.00559 Highly Informative Inherited
Biological Process (BP) cell growth 0.03695 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 0.004546 Least Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 0 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0 Moderately Informative Direct
Molecular Function (MF) protein binding 0.08529 Moderately Informative Inherited
Molecular Function (MF) metal ion binding 0.1381 Moderately Informative Inherited
Molecular Function (MF) purine nucleoside binding 0 Informative Direct
Molecular Function (MF) ribonucleoside binding 0 Informative Direct
Molecular Function (MF) purine nucleotide binding 0 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.0000000000001079 Informative Direct
Molecular Function (MF) ribonucleotide binding 0.000000000005789 Informative Direct
Molecular Function (MF) receptor binding 0.0000003808 Informative Direct
Molecular Function (MF) signal transducer activity 0.000004261 Informative Direct
Molecular Function (MF) magnesium ion binding 0.000007591 Informative Direct
Molecular Function (MF) G-protein coupled receptor binding 0 Highly Informative Direct
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) protein complex 0.0000000005934 Least Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0.9535 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.0000000000003696 Moderately Informative Direct
Cellular Component (CC) membrane protein complex 0.0000000007946 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.000001912 Moderately Informative Direct
Cellular Component (CC) whole membrane 1 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.7934 Moderately Informative Inherited
Cellular Component (CC) vesicle 0.001765 Moderately Informative Inherited
Cellular Component (CC) extrinsic component of membrane 0 Informative Direct
Cellular Component (CC) cell projection part 0 Informative Direct
Cellular Component (CC) cilium 0 Informative Direct
Cellular Component (CC) plasma membrane protein complex 0 Informative Direct
Cellular Component (CC) side of membrane 0 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 0.00004091 Informative Direct
Cellular Component (CC) membrane region 0.4605 Informative Inherited
Cellular Component (CC) secretory vesicle 0.005776 Informative Inherited
Cellular Component (CC) centrosome 0 Highly Informative Direct
Cellular Component (CC) GTPase complex 0 Highly Informative Direct
Cellular Component (CC) extrinsic component of cytoplasmic side of plasma membrane 0 Highly Informative Direct
Cellular Component (CC) midbody 0 Highly Informative Direct
Cellular Component (CC) 9+2 non-motile cilium 0.001464 Highly Informative Inherited

Document: GO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.8475Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of forebrain morphology0.1774Moderately InformativeInherited
Phenotypic Abnormality (PA)Ectopic calcification0.003347Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.04192Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.06106Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.06763Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.1561Least InformativeInherited
Mammalian Phenotype (MP)abnormal muscle physiology0.02475Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.03557Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.0799Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.1218Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.2014Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology0.2319Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.2678Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood coagulation0.001395InformativeInherited
Mammalian Phenotype (MP)abnormal systemic arterial blood pressure0.001581InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin secretion0.002043InformativeInherited
Mammalian Phenotype (MP)impaired muscle contractility0.002596InformativeInherited
Mammalian Phenotype (MP)abnormal touch/ nociception0.008507InformativeInherited
Mammalian Phenotype (MP)abnormal thoracic cage morphology0.01876InformativeInherited
Mammalian Phenotype (MP)abnormal eye physiology0.04283InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel physiology0.07953InformativeInherited
Mammalian Phenotype (MP)abnormal ion homeostasis0.1249InformativeInherited
Mammalian Phenotype (MP)abnormal appendicular skeleton morphology0.1891InformativeInherited
Mammalian Phenotype (MP)abnormal vertebral column morphology0.6932InformativeInherited
Mammalian Phenotype (MP)decreased systemic arterial blood pressure0.000001358Highly InformativeDirect
Mammalian Phenotype (MP)decreased platelet aggregation0.000003703Highly InformativeDirect
Mammalian Phenotype (MP)abnormal rib morphology0.0002591Highly InformativeDirect
Mammalian Phenotype (MP)abnormal vascular smooth muscle physiology0.0009555Highly InformativeDirect
Mammalian Phenotype (MP)abnormal calcium ion homeostasis0.001417Highly InformativeInherited
Mammalian Phenotype (MP)abnormal joint morphology0.001702Highly InformativeInherited
Mammalian Phenotype (MP)abnormal lumbar vertebrae morphology0.002351Highly InformativeInherited
Mammalian Phenotype (MP)abnormal eye electrophysiology0.004209Highly InformativeInherited
Mammalian Phenotype (MP)abnormal mineral level0.02601Highly InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin-2 secretion0.09355Highly InformativeInherited
Mammalian Phenotype (MP)abnormal tumor necrosis factor secretion0.1555Highly InformativeInherited
Mammalian Phenotype (MP)abnormal sternum morphology0.2895Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)general pace of development variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Least InformativeDirect
Worm Phenotype (WP)retarded heterochronic variations0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval growth variant0Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.000000000000001712Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.00000000000007186Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.05835Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.356Least InformativeInherited
Worm Phenotype (WP)cell morphology variant0.4356Least InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0Moderately InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect
Worm Phenotype (WP)movement variant0Moderately InformativeDirect
Worm Phenotype (WP)cell component morphology variant0.1653Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant1Moderately InformativeInherited
Worm Phenotype (WP)body posture variant0InformativeDirect
Worm Phenotype (WP)foraging behavior variant0InformativeDirect
Worm Phenotype (WP)localized movement variant0InformativeDirect
Worm Phenotype (WP)locomotor coordination variant0.0000000000006934InformativeDirect
Worm Phenotype (WP)forward locomotion variant0.00000000008126InformativeDirect
Worm Phenotype (WP)velocity of movement variant0.0000002385InformativeDirect
Worm Phenotype (WP)electrophysiology variant0.00002014InformativeDirect
Worm Phenotype (WP)aldicarb response variant0.0005298InformativeDirect
Worm Phenotype (WP)chemotaxis variant0.002117InformativeInherited
Worm Phenotype (WP)protein modification variant0.02061InformativeInherited
Worm Phenotype (WP)organelle organization biogenesis variant0.02621InformativeInherited
Worm Phenotype (WP)body width variant0.7399InformativeInherited
Worm Phenotype (WP)body length variant0.8629InformativeInherited
Worm Phenotype (WP)locomotion reduced1InformativeInherited
Worm Phenotype (WP)carbon dioxide avoidance variant0Highly InformativeDirect
Worm Phenotype (WP)coiling frequency0Highly InformativeDirect
Worm Phenotype (WP)amplitude of sinusoidal movement variant0Highly InformativeDirect
Worm Phenotype (WP)fat0.000000000004072Highly InformativeDirect
Worm Phenotype (WP)roaming variant0.0000000002201Highly InformativeDirect
Worm Phenotype (WP)foraging hyperactive0.0000000004301Highly InformativeDirect
Worm Phenotype (WP)drug induced gene expression variant0.000000001888Highly InformativeDirect
Worm Phenotype (WP)pausing variant0.0000002199Highly InformativeDirect
Worm Phenotype (WP)protein phosphorylation variant0.00009404Highly InformativeDirect
Worm Phenotype (WP)cytoskeleton organization biogenesis variant0.000156Highly InformativeDirect
Worm Phenotype (WP)path curvature variant0.0002835Highly InformativeDirect
Worm Phenotype (WP)backward point velocity variant0.5957Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)wild-type0.0005756InformativeDirect
Fly Phenotype (FP)sensory perception defective0.0008314InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)nervous system0.09327Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.1552Least InformativeInherited
Fly Anatomy (FA)cell0.2166Least InformativeInherited
Fly Anatomy (FA)anatomical group0.2826Least InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.08489Moderately InformativeInherited
Fly Anatomy (FA)neuron0.1644Moderately InformativeInherited
Fly Anatomy (FA)cell cluster organ0.2799Moderately InformativeInherited
Fly Anatomy (FA)sense organ0.3789Moderately InformativeInherited
Fly Anatomy (FA)chemosensory system0.00008737InformativeDirect
Fly Anatomy (FA)eo neuron0.00004047Highly InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system0.2673Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.4089Least InformativeInherited
Xenopus ANatomical entity (XAN)sensory system0.06398Moderately InformativeInherited
Xenopus ANatomical entity (XAN)brain0.07701Moderately InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.5981Moderately InformativeInherited
Xenopus ANatomical entity (XAN)forebrain0.0356InformativeInherited
Xenopus ANatomical entity (XAN)telencephalon0.000191Highly InformativeDirect
Xenopus ANatomical entity (XAN)olfactory system0.005412Highly InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)portion of meristem tissue0Least InformativeDirect
Plant ANatomical entity (PAN)megasporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)sporangium0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence meristem0Moderately InformativeDirect
Plant ANatomical entity (PAN)cotyledon0Moderately InformativeDirect
Plant ANatomical entity (PAN)rosette leaf0.000002288InformativeDirect
Plant ANatomical entity (PAN)fruit0.00001326InformativeDirect
Plant ANatomical entity (PAN)shoot axis stele0.0000000006626Highly InformativeDirect
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.12 twelve leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.08 eight leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.02 two leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCell cycle0.00000000007275Moderately InformativeDirect
Biological processSensory transduction0.000000000000617InformativeDirect
Biological processVision0.0001447Highly InformativeDirect
Cellular componentMembrane0.00000002712Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentCytoskeleton0.0000000000005911Moderately InformativeDirect
Cellular componentCell membrane0.000004961Moderately InformativeDirect
DiseaseDisease mutation0.00006662Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionMagnesium0Moderately InformativeDirect
Molecular functionGTP-binding0InformativeDirect
Post-translational modificationPalmitate0Moderately InformativeDirect
Post-translational modificationMyristate0InformativeDirect
Post-translational modificationADP-ribosylation0Highly InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR011025 SSF47895 Protein matches
Abstract

Guanine nucleotide binding proteins (G proteins) are membrane-associated, heterotrimeric proteins composed of three subunits: alpha , beta and gamma [PubMed15119945]. G proteins act as signal transducers, relaying a signal from a ligand-activated GPCR (G protein-coupled receptor) to an enzyme or ion channel effector. The activated GPCR promotes the exchange of GDP for GTP on the G protein alpha subunit, allowing the trimeric G protein to be released from the receptor and to dissociate into active (GTP-bound) alpha subunit and beta/gamma dimer, both of which activate distinct downstream effectors. There are several isoforms of each subunit, which together can makeup hundreds of combinations of G proteins, each one linking a specific receptor to a certain effector.

The heterotrimeric G protein alpha subunit is composed of two domains: a GTP-binding domain and a helical insertion domain. The GTP-binding domain is homologous to Ras-like small GTPases, and includes switch regions I and II, which change conformation during activation. The helical insertion domain is inserted into the GTP-binding domain before switch region I, and is unique to heterotrimeric G proteins. This helical insertion domain functions to sequester the guanine nucleotide at the interface with the GTP-binding domain and must be displaced to enable nucleotide dissociation [PubMed12517447]. This entry represents the G protein alpha subunit helical insertion domain.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 6 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Transducin (alpha subunit), insertion domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 6 hidden Markov models representing the Transducin (alpha subunit), insertion domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]