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Transducin (alpha subunit), insertion domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Transducin (alpha subunit), insertion domain [ 47894]
Superfamily:   Transducin (alpha subunit), insertion domain [ 47895]
Families:   Transducin (alpha subunit), insertion domain [ 47896]


Superfamily statistics
Genomes (449) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 3,875 0 25
Proteins 3,834 0 25


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.04754Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.06841Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.08037Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.1604Least InformativeInherited
Mammalian Phenotype (MP)abnormal muscle physiology0.02372Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.04011Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.08209Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.1071Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.2059Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology0.2266Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.2706Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood coagulation0.001282InformativeInherited
Mammalian Phenotype (MP)abnormal systemic arterial blood pressure0.001458InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin secretion0.001908InformativeInherited
Mammalian Phenotype (MP)impaired muscle contractility0.00249InformativeInherited
Mammalian Phenotype (MP)abnormal touch/ nociception0.007459InformativeInherited
Mammalian Phenotype (MP)abnormal vertebrae morphology0.01026InformativeInherited
Mammalian Phenotype (MP)abnormal thoracic cage morphology0.01746InformativeInherited
Mammalian Phenotype (MP)abnormal eye physiology0.0414InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel physiology0.0754InformativeInherited
Mammalian Phenotype (MP)abnormal ion homeostasis0.1387InformativeInherited
Mammalian Phenotype (MP)abnormal appendicular skeleton morphology0.1731InformativeInherited
Mammalian Phenotype (MP)decreased systemic arterial blood pressure0.000001232Highly InformativeDirect
Mammalian Phenotype (MP)decreased platelet aggregation0.000003417Highly InformativeDirect
Mammalian Phenotype (MP)abnormal rib morphology0.0002589Highly InformativeDirect
Mammalian Phenotype (MP)abnormal vascular smooth muscle physiology0.0009398Highly InformativeDirect
Mammalian Phenotype (MP)abnormal joint morphology0.001552Highly InformativeInherited
Mammalian Phenotype (MP)abnormal calcium ion homeostasis0.001669Highly InformativeInherited
Mammalian Phenotype (MP)abnormal lumbar vertebrae morphology0.002376Highly InformativeInherited
Mammalian Phenotype (MP)abnormal eye electrophysiology0.004002Highly InformativeInherited
Mammalian Phenotype (MP)abnormal mineral level0.02989Highly InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin-2 secretion0.09379Highly InformativeInherited
Mammalian Phenotype (MP)abnormal tumor necrosis factor secretion0.1559Highly InformativeInherited
Mammalian Phenotype (MP)abnormal sternum morphology0.2825Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)general pace of development variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Least InformativeDirect
Worm Phenotype (WP)retarded heterochronic variations0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval growth variant0Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.0000000000000283Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.00000000000009789Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.08137Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.4067Least InformativeInherited
Worm Phenotype (WP)cell morphology variant0.4937Least InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0Moderately InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect
Worm Phenotype (WP)movement variant0Moderately InformativeDirect
Worm Phenotype (WP)protein expression variant0.1586Moderately InformativeInherited
Worm Phenotype (WP)cell component morphology variant0.2179Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant1Moderately InformativeInherited
Worm Phenotype (WP)body posture variant0InformativeDirect
Worm Phenotype (WP)foraging behavior variant0InformativeDirect
Worm Phenotype (WP)localized movement variant0InformativeDirect
Worm Phenotype (WP)locomotor coordination variant0.0000000000007605InformativeDirect
Worm Phenotype (WP)forward locomotion variant0.000000000086InformativeDirect
Worm Phenotype (WP)velocity of movement variant0.0000001987InformativeDirect
Worm Phenotype (WP)electrophysiology variant0.00002902InformativeDirect
Worm Phenotype (WP)aldicarb response variant0.0006091InformativeDirect
Worm Phenotype (WP)chemotaxis variant0.002352InformativeInherited
Worm Phenotype (WP)protein modification variant0.01388InformativeInherited
Worm Phenotype (WP)organelle organization biogenesis variant0.0305InformativeInherited
Worm Phenotype (WP)body width variant0.7289InformativeInherited
Worm Phenotype (WP)body length variant0.8628InformativeInherited
Worm Phenotype (WP)locomotion reduced1InformativeInherited
Worm Phenotype (WP)carbon dioxide avoidance variant0Highly InformativeDirect
Worm Phenotype (WP)coiling frequency0Highly InformativeDirect
Worm Phenotype (WP)nose movement variant0Highly InformativeDirect
Worm Phenotype (WP)amplitude of sinusoidal movement variant0Highly InformativeDirect
Worm Phenotype (WP)fat0.000000000004078Highly InformativeDirect
Worm Phenotype (WP)roaming variant0.0000000001841Highly InformativeDirect
Worm Phenotype (WP)foraging hyperactive0.0000000002526Highly InformativeDirect
Worm Phenotype (WP)drug induced gene expression variant0.000000001612Highly InformativeDirect
Worm Phenotype (WP)pausing variant0.0000001808Highly InformativeDirect
Worm Phenotype (WP)protein phosphorylation variant0.0001471Highly InformativeDirect
Worm Phenotype (WP)cytoskeleton organization biogenesis variant0.000172Highly InformativeDirect
Worm Phenotype (WP)path curvature variant0.0002835Highly InformativeDirect
Worm Phenotype (WP)backward point velocity variant0.5996Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)wild-type0.000521InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)nervous system0.09781Least InformativeInherited
Fly Anatomy (FA)somatic cell0.1621Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.1692Least InformativeInherited
Fly Anatomy (FA)anatomical group0.2789Least InformativeInherited
Fly Anatomy (FA)sensory neuron0.07543Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.09462Moderately InformativeInherited
Fly Anatomy (FA)cell cluster organ0.2693Moderately InformativeInherited
Fly Anatomy (FA)sense organ0.3671Moderately InformativeInherited
Fly Anatomy (FA)chemosensory system0.00008091InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system0.1575Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.1869Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.209Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.2925Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.3607Least InformativeInherited
Xenopus ANatomical entity (XAN)sensory system0.002476Moderately InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.01085Moderately InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.1769Moderately InformativeInherited
Xenopus ANatomical entity (XAN)brain0.1824Moderately InformativeInherited
Xenopus ANatomical entity (XAN)epithelium0.008063InformativeInherited
Xenopus ANatomical entity (XAN)forebrain0.02672InformativeInherited
Xenopus ANatomical entity (XAN)animal hemisphere0.00002104Highly InformativeDirect
Xenopus ANatomical entity (XAN)dorsal marginal zone0.000551Highly InformativeDirect
Xenopus ANatomical entity (XAN)neuron0.0006727Highly InformativeDirect
Xenopus DEvelopment stage (XDE)post-embryonic stage0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)portion of meristem tissue0Least InformativeDirect
Plant ANatomical entity (PAN)megasporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)sporangium0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence meristem0Moderately InformativeDirect
Plant ANatomical entity (PAN)cotyledon0Moderately InformativeDirect
Plant ANatomical entity (PAN)rosette leaf0.000002288InformativeDirect
Plant ANatomical entity (PAN)fruit0.00001326InformativeDirect
Plant ANatomical entity (PAN)shoot axis stele0.0000000006626Highly InformativeDirect
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.12 twelve leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.08 eight leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.02 two leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCell cycle0.0000000001224Moderately InformativeDirect
Biological processSensory transduction0.0000000000005721InformativeDirect
Biological processVision0.0001374Highly InformativeDirect
Cellular componentMembrane0.000000000839Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentCytoskeleton0.0000000000009646Moderately InformativeDirect
Cellular componentCell membrane0.000001343Moderately InformativeDirect
DiseaseDisease mutation0.0001169Least InformativeDirect
Molecular functionMagnesium0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionGTP-binding0InformativeDirect
Post-translational modificationTransducer0InformativeDirect
Post-translational modificationPalmitate0Moderately InformativeDirect
Post-translational modificationMyristate0InformativeDirect
Post-translational modificationADP-ribosylation0.000000000000001936InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR011025 SSF47895 Protein matches
Abstract

Guanine nucleotide binding proteins (G proteins) are membrane-associated, heterotrimeric proteins composed of three subunits: alpha , beta and gamma [PubMed15119945]. G proteins act as signal transducers, relaying a signal from a ligand-activated GPCR (G protein-coupled receptor) to an enzyme or ion channel effector. The activated GPCR promotes the exchange of GDP for GTP on the G protein alpha subunit, allowing the trimeric G protein to be released from the receptor and to dissociate into active (GTP-bound) alpha subunit and beta/gamma dimer, both of which activate distinct downstream effectors. There are several isoforms of each subunit, which together can makeup hundreds of combinations of G proteins, each one linking a specific receptor to a certain effector.

The heterotrimeric G protein alpha subunit is composed of two domains: a GTP-binding domain and a helical insertion domain. The GTP-binding domain is homologous to Ras-like small GTPases, and includes switch regions I and II, which change conformation during activation. The helical insertion domain is inserted into the GTP-binding domain before switch region I, and is unique to heterotrimeric G proteins. This helical insertion domain functions to sequester the guanine nucleotide at the interface with the GTP-binding domain and must be displaced to enable nucleotide dissociation [PubMed12517447]. This entry represents the G protein alpha subunit helical insertion domain.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 6 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Transducin (alpha subunit), insertion domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 6 hidden Markov models representing the Transducin (alpha subunit), insertion domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]