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Transducin (alpha subunit), insertion domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Transducin (alpha subunit), insertion domain [ 47894]
Superfamily:   Transducin (alpha subunit), insertion domain [ 47895]
Families:   Transducin (alpha subunit), insertion domain [ 47896]


Superfamily statistics
Genomes (449) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 3,875 9,580 25
Proteins 3,834 9,487 25


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.6439 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) response to abiotic stimulus 0 Moderately Informative Direct
Biological Process (BP) single organism signaling 0 Moderately Informative Direct
Biological Process (BP) cell communication 0 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.000000000000007296 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.0000002975 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.003742 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.8339 Moderately Informative Inherited
Biological Process (BP) purine-containing compound metabolic process 0.06637 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) animal organ development 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.209 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.08245 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.5574 Moderately Informative Inherited
Biological Process (BP) nucleoside phosphate metabolic process 0.1594 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.6736 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.7789 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.94 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.6184 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.3597 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.7656 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.961 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.9669 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.1031 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.05341 Moderately Informative Inherited
Biological Process (BP) response to nitrogen compound 0 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0 Informative Direct
Biological Process (BP) response to radiation 0 Informative Direct
Biological Process (BP) system process 0.000001184 Informative Direct
Biological Process (BP) cellular response to lipid 0.0001292 Informative Direct
Biological Process (BP) glycosyl compound metabolic process 0.0007043 Informative Direct
Biological Process (BP) regulation of system process 0.0008731 Informative Direct
Biological Process (BP) regulation of protein localization 0.05307 Informative Inherited
Biological Process (BP) response to organic cyclic compound 1 Informative Inherited
Biological Process (BP) regulation of cellular localization 0.219 Informative Inherited
Biological Process (BP) actin cytoskeleton organization 0.01082 Informative Inherited
Biological Process (BP) localization of cell 0.2139 Informative Inherited
Biological Process (BP) movement of cell or subcellular component 0.451 Informative Inherited
Biological Process (BP) circulatory system development 0.09846 Informative Inherited
Biological Process (BP) regulation of cell cycle 1 Informative Inherited
Biological Process (BP) embryo development 0.1499 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.02417 Informative Inherited
Biological Process (BP) supramolecular fiber organization 0.01652 Informative Inherited
Biological Process (BP) central nervous system development 0.04315 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.01033 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.9453 Informative Inherited
Biological Process (BP) locomotion 0.218 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.08962 Informative Inherited
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 0.1866 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.1478 Informative Inherited
Biological Process (BP) cell activation 0.007416 Informative Inherited
Biological Process (BP) cell development 0.04446 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 0.03373 Informative Inherited
Biological Process (BP) growth 0.03054 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.1637 Informative Inherited
Biological Process (BP) response to wounding 0.004687 Informative Inherited
Biological Process (BP) cation homeostasis 0.002773 Informative Inherited
Biological Process (BP) inorganic ion homeostasis 0.003106 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 0.1814 Informative Inherited
Biological Process (BP) epithelium development 0.02111 Informative Inherited
Biological Process (BP) regulation of circadian rhythm 0 Highly Informative Direct
Biological Process (BP) regulation of cyclic nucleotide metabolic process 0 Highly Informative Direct
Biological Process (BP) G-protein coupled receptor signaling pathway 0 Highly Informative Direct
Biological Process (BP) positive regulation of nucleotide metabolic process 0.000000000007075 Highly Informative Direct
Biological Process (BP) second-messenger-mediated signaling 0.00000000009001 Highly Informative Direct
Biological Process (BP) coagulation 0.00000012 Highly Informative Direct
Biological Process (BP) hemostasis 0.0000001411 Highly Informative Direct
Biological Process (BP) purine ribonucleoside metabolic process 0.000007365 Highly Informative Direct
Biological Process (BP) gliogenesis 0.000008668 Highly Informative Direct
Biological Process (BP) positive regulation of cellular protein localization 0.00003475 Highly Informative Direct
Biological Process (BP) wound healing 0.000386 Highly Informative Direct
Biological Process (BP) protein folding 0.000402 Highly Informative Direct
Biological Process (BP) response to ketone 0.09355 Highly Informative Inherited
Biological Process (BP) actin filament organization 0.004195 Highly Informative Inherited
Biological Process (BP) heart development 0.02631 Highly Informative Inherited
Biological Process (BP) regulation of microtubule-based process 0.003083 Highly Informative Inherited
Biological Process (BP) gastrulation 0.002431 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.02795 Highly Informative Inherited
Biological Process (BP) actomyosin structure organization 0.03083 Highly Informative Inherited
Biological Process (BP) cell growth 0.001359 Highly Informative Inherited
Biological Process (BP) developmental growth involved in morphogenesis 0.004247 Highly Informative Inherited
Biological Process (BP) nervous system process 0.00364 Highly Informative Inherited
Biological Process (BP) small GTPase mediated signal transduction 0.1365 Highly Informative Inherited
Biological Process (BP) cellular calcium ion homeostasis 0.5534 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0.00000000000000397 Least Informative Direct
Molecular Function (MF) binding 0.06274 Least Informative Inherited
Molecular Function (MF) anion binding 0 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0 Moderately Informative Direct
Molecular Function (MF) metal ion binding 0.1993 Moderately Informative Inherited
Molecular Function (MF) purine nucleotide binding 0 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.00000000000003587 Informative Direct
Molecular Function (MF) ribonucleotide binding 0.00000000002029 Informative Direct
Molecular Function (MF) receptor binding 0.0000001342 Informative Direct
Molecular Function (MF) signal transducer activity 0.000004553 Informative Direct
Molecular Function (MF) magnesium ion binding 0.00001667 Informative Direct
Molecular Function (MF) purine nucleoside binding 0 Highly Informative Direct
Molecular Function (MF) G-protein coupled receptor binding 0 Highly Informative Direct
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) protein complex 0.000000003722 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.9278 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) membrane protein complex 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.00000000008371 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.0000007546 Moderately Informative Direct
Cellular Component (CC) whole membrane 1 Moderately Informative Inherited
Cellular Component (CC) cilium 0 Informative Direct
Cellular Component (CC) side of membrane 0 Informative Direct
Cellular Component (CC) plasma membrane protein complex 0 Informative Direct
Cellular Component (CC) extrinsic component of membrane 0 Informative Direct
Cellular Component (CC) neuron projection 0.000000001037 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 0.0000054 Informative Direct
Cellular Component (CC) cytoplasmic region 0.000005785 Informative Direct
Cellular Component (CC) plasma membrane bounded cell projection part 0.00001737 Informative Direct
Cellular Component (CC) membrane region 0.5593 Informative Inherited
Cellular Component (CC) GTPase complex 0 Highly Informative Direct
Cellular Component (CC) extrinsic component of cytoplasmic side of plasma membrane 0 Highly Informative Direct
Cellular Component (CC) photoreceptor cell cilium 0 Highly Informative Direct
Cellular Component (CC) midbody 0 Highly Informative Direct
Cellular Component (CC) microtubule organizing center 0.00000000006806 Highly Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCell cycle0.00000000007341Moderately InformativeDirect
Biological processSensory transduction0.0000000000006149InformativeDirect
Biological processVision0.0001454Highly InformativeDirect
Cellular componentMembrane0.00000003528Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentCytoskeleton0.0000000000008315Moderately InformativeDirect
Cellular componentCell membrane0.000000014Moderately InformativeDirect
DiseaseDisease mutation0.00009511Least InformativeDirect
Molecular functionMagnesium0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionGTP-binding0InformativeDirect
Post-translational modificationPalmitate0Moderately InformativeDirect
Post-translational modificationMyristate0InformativeDirect
Post-translational modificationADP-ribosylation9.634e-16InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR011025 SSF47895 Protein matches
Abstract

Guanine nucleotide binding proteins (G proteins) are membrane-associated, heterotrimeric proteins composed of three subunits: alpha , beta and gamma [PubMed15119945]. G proteins act as signal transducers, relaying a signal from a ligand-activated GPCR (G protein-coupled receptor) to an enzyme or ion channel effector. The activated GPCR promotes the exchange of GDP for GTP on the G protein alpha subunit, allowing the trimeric G protein to be released from the receptor and to dissociate into active (GTP-bound) alpha subunit and beta/gamma dimer, both of which activate distinct downstream effectors. There are several isoforms of each subunit, which together can makeup hundreds of combinations of G proteins, each one linking a specific receptor to a certain effector.

The heterotrimeric G protein alpha subunit is composed of two domains: a GTP-binding domain and a helical insertion domain. The GTP-binding domain is homologous to Ras-like small GTPases, and includes switch regions I and II, which change conformation during activation. The helical insertion domain is inserted into the GTP-binding domain before switch region I, and is unique to heterotrimeric G proteins. This helical insertion domain functions to sequester the guanine nucleotide at the interface with the GTP-binding domain and must be displaced to enable nucleotide dissociation [PubMed12517447]. This entry represents the G protein alpha subunit helical insertion domain.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 6 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Transducin (alpha subunit), insertion domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 6 hidden Markov models representing the Transducin (alpha subunit), insertion domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]