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C-terminal domain of alpha and beta subunits of F1 ATP synthase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Left-handed superhelix [ 47916] (4)
Superfamily:   C-terminal domain of alpha and beta subunits of F1 ATP synthase [ 47917]
Families:   C-terminal domain of alpha and beta subunits of F1 ATP synthase [ 47918] (2)


Superfamily statistics
Genomes (3,128) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 7,989 59,779 12
Proteins 7,982 59,762 12


Functional annotation
General category Metabolism
Detailed category Energy

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular nitrogen compound metabolic process 0.01352 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.01321 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.01986 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.004401 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.5731 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.003862 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 0.1068 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.293 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.009611 Least Informative Inherited
Biological Process (BP) purine-containing compound metabolic process 0.000000000000003764 Moderately Informative Direct
Biological Process (BP) nucleoside phosphate metabolic process 0.0000000000002377 Moderately Informative Direct
Biological Process (BP) organophosphate biosynthetic process 0.000000000003296 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0.000000004386 Moderately Informative Direct
Biological Process (BP) ion transport 0.00000002208 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0.0000001061 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0.0000001912 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0.000001019 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.1163 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.002402 Moderately Informative Inherited
Biological Process (BP) ATP metabolic process 0 Informative Direct
Biological Process (BP) purine-containing compound biosynthetic process 0 Informative Direct
Biological Process (BP) ribose phosphate biosynthetic process 0.00000000002804 Informative Direct
Biological Process (BP) transmembrane transport 0.00000000004293 Informative Direct
Biological Process (BP) ion homeostasis 0.000001123 Informative Direct
Biological Process (BP) nucleotide biosynthetic process 0.0000358 Informative Direct
Biological Process (BP) cellular chemical homeostasis 0.008823 Informative Inherited
Biological Process (BP) inorganic cation transmembrane transport 0 Highly Informative Direct
Biological Process (BP) pH reduction 0.00000000001019 Highly Informative Direct
Biological Process (BP) proton transport 0.00000000003224 Highly Informative Direct
Biological Process (BP) nucleoside triphosphate biosynthetic process 0.00000000009118 Highly Informative Direct
Biological Process (BP) regulation of intracellular pH 0.0000000002887 Highly Informative Direct
Biological Process (BP) purine ribonucleoside monophosphate biosynthetic process 0.00000006182 Highly Informative Direct
Molecular Function (MF) hydrolase activity 0.000003899 Least Informative Direct
Molecular Function (MF) binding 0.3873 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.000000000000001646 Moderately Informative Direct
Molecular Function (MF) transporter activity 0.00000000004211 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.006132 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 0.02083 Moderately Informative Inherited
Molecular Function (MF) monovalent inorganic cation transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) ATPase activity 0 Informative Direct
Molecular Function (MF) active transmembrane transporter activity 0.00000007521 Informative Direct
Molecular Function (MF) purine nucleotide binding 0.0005761 Informative Direct
Molecular Function (MF) ribonucleotide binding 0.0006626 Informative Direct
Molecular Function (MF) ATPase coupled ion transmembrane transporter activity 0 Highly Informative Direct
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) macromolecular complex 0.00000003766 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.000001449 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.00000656 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.007252 Least Informative Inherited
Cellular Component (CC) organelle envelope 0 Moderately Informative Direct
Cellular Component (CC) membrane protein complex 0 Moderately Informative Direct
Cellular Component (CC) mitochondrial part 0.0000000000002498 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.00002703 Moderately Informative Direct
Cellular Component (CC) whole membrane 0.4361 Moderately Informative Inherited
Cellular Component (CC) bounding membrane of organelle 1 Moderately Informative Inherited
Cellular Component (CC) apical part of cell 0 Informative Direct
Cellular Component (CC) proton-transporting two-sector ATPase complex 0 Informative Direct
Cellular Component (CC) inner mitochondrial membrane protein complex 0.000000007588 Informative Direct
Cellular Component (CC) plasma membrane region 0.0000001591 Informative Direct
Cellular Component (CC) vacuolar part 0.000006638 Informative Direct
Cellular Component (CC) plastid 0.0009029 Informative Direct
Cellular Component (CC) apical plasma membrane 0 Highly Informative Direct
Cellular Component (CC) proton-transporting ATP synthase complex, catalytic core F(1) 0 Highly Informative Direct
Cellular Component (CC) mitochondrial proton-transporting ATP synthase complex 0.000003833 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; catalyzing transmembran0InformativeDirect
Enzyme Commission (EC)H(+)-transporting two-sector ATPase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell morphology variant0Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)retarded heterochronic variations0Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0Least InformativeDirect
Worm Phenotype (WP)general pace of development variant0Least InformativeDirect
Worm Phenotype (WP)cell development variant0Least InformativeDirect
Worm Phenotype (WP)larval growth variant0Least InformativeDirect
Worm Phenotype (WP)gametogenesis variant0Moderately InformativeDirect
Worm Phenotype (WP)protein protein interaction variant0Moderately InformativeDirect
Worm Phenotype (WP)reproductive system morphology variant0Moderately InformativeDirect
Worm Phenotype (WP)cell division variant0Moderately InformativeDirect
Worm Phenotype (WP)cell component morphology variant0Moderately InformativeDirect
Worm Phenotype (WP)apoptosis variant0Moderately InformativeDirect
Worm Phenotype (WP)reproductive system development variant0Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0Moderately InformativeDirect
Worm Phenotype (WP)germ cell morphology variant0Moderately InformativeDirect
Worm Phenotype (WP)oocyte morphology variant0InformativeDirect
Worm Phenotype (WP)gonad development variant0InformativeDirect
Worm Phenotype (WP)endosome morphology variant0InformativeDirect
Worm Phenotype (WP)diplotene progression during oogenesis variant0InformativeDirect
Worm Phenotype (WP)cell membrane organization biogenesis variant0Highly InformativeDirect
Worm Phenotype (WP)lysosome-related organelle morphology variant0Highly InformativeDirect
Worm Phenotype (WP)oocyte septum formation variant0Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect
Yeast Phenotype (YP)metabolism and growth0Least InformativeDirect
Yeast Phenotype (YP)morphology0Moderately InformativeDirect
Yeast Phenotype (YP)nutrient utilization0Moderately InformativeDirect
Yeast Phenotype (YP)lifespan0InformativeDirect
Yeast Phenotype (YP)chemical compound accumulation0InformativeDirect
Yeast Phenotype (YP)respiratory metabolism0InformativeDirect
Yeast Phenotype (YP)vegetative growth0InformativeDirect
Yeast Phenotype (YP)respiratory growth0Highly InformativeDirect
Yeast Phenotype (YP)chronological lifespan0Highly InformativeDirect
Yeast Phenotype (YP)desiccation resistance0Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect
Fly Phenotype (FP)increased mortality0Least InformativeDirect
Fly Phenotype (FP)sterile0InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)anatomical cluster0Least InformativeDirect
Xenopus ANatomical entity (XAN)nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)cell0Least InformativeDirect
Xenopus ANatomical entity (XAN)embryo0Least InformativeDirect
Xenopus ANatomical entity (XAN)tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)brain0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)ectoderm0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)multi-tissue structure0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)visual system0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)immune system0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)alimentary system0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)skin0InformativeDirect
Xenopus ANatomical entity (XAN)endomesoderm0InformativeDirect
Xenopus ANatomical entity (XAN)intestine0InformativeDirect
Xenopus ANatomical entity (XAN)limb0InformativeDirect
Xenopus ANatomical entity (XAN)kidney0InformativeDirect
Xenopus ANatomical entity (XAN)lung0InformativeDirect
Xenopus ANatomical entity (XAN)spleen0InformativeDirect
Xenopus ANatomical entity (XAN)heart0InformativeDirect
Xenopus ANatomical entity (XAN)oocyte0Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)sporangium0Least InformativeDirect
Plant structure DEvelopment stage (PDE)seed development stage0InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; catalyzing transmembrane movement of substances0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processIon transport0Moderately InformativeDirect
Biological processATP synthesis0Highly InformativeDirect
Biological processHydrogen ion transport0Highly InformativeDirect
Biological processIntron homing0.00009906Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentPlastid0Moderately InformativeDirect
Cellular componentCell membrane0Moderately InformativeDirect
Cellular componentMitochondrion1Moderately InformativeInherited
Cellular componentThylakoid0InformativeDirect
Cellular componentCell inner membrane0InformativeDirect
Cellular componentMitochondrion inner membrane0.0000000004291InformativeDirect
Cellular componentCF(1)0Highly InformativeDirect
Coding sequence diversityRNA editing0.0007178Moderately InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationAutocatalytic cleavage0.6435InformativeInherited
Post-translational modificationProtein splicing0.000000007668Highly InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR000793 SSF47917 Protein matches
Abstract

This entry represents the alpha and beta subunits found in the F1, V1, and A1 complexes of F-, V- and A-ATPases, respectively (sometimes called the A and B subunits in V- and A-ATPases). The F-ATPases (or F1F0-ATPases), V-ATPases (or V1V0-ATPases) and A-ATPases (or A1A0-ATPases) are composed of two linked complexes: the F1, V1 or A1 complex contains the catalytic core that synthesizes/hydrolyses ATP, and the F0, V0 or A0 complex that forms the membrane-spanning pore. The F-, V- and A-ATPases all contain rotary motors, one that drives proton translocation across the membrane and one that drives ATP synthesis/hydrolysis [PubMed11309608, PubMed15629643].

In F-ATPases, there are three copies each of the alpha and beta subunits that form the catalytic core of the F1 complex, while the remaining F1 subunits (gamma, delta, epsilon) form part of the stalks. There is a substrate-binding site on each of the alpha and beta subunits, those on the beta subunits being catalytic, while those on the alpha subunits are regulatory. The alpha and beta subunits form a cylinder that is attached to the central stalk. The alpha/beta subunits undergo a sequence of conformational changes leading to the formation of ATP from ADP, which are induced by the rotation of the gamma subunit, itself is driven by the movement of protons through the F0 complex C subunit [PubMed12745923].

In V- and A-ATPases, the alpha/A and beta/B subunits of the V1 or A1 complex are homologous to the alpha and beta subunits in the F1 complex of F-ATPases, except that the alpha subunit is catalytic and the beta subunit is regulatory.

The alpha/A and beta/B subunits can each be divided into three regions, or domains, centred around the ATP-binding pocket, and based on structure and function, where the central region is the nucleotide-binding domain [PubMed12885621]. This entry represents the C-terminal domain of the alpha/A/beta/B subunits, which forms a left-handed superhelix composed of 4-5 individual helices. The C-terminal domain can vary between the alpha and beta subunits, and between different ATPases [PubMed11309608].

More information about this protein can be found at Protein of the Month: ATP Synthases.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 6 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a C-terminal domain of alpha and beta subunits of F1 ATP synthase domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 6 hidden Markov models representing the C-terminal domain of alpha and beta subunits of F1 ATP synthase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]