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Cyclin-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Cyclin-like [ 47953]
Superfamily:   Cyclin-like [ 47954] (3)
Families:   Cyclin [ 47955] (8)
  Transcription factor IIB (TFIIB), core domain [ 47965]
  Retinoblastoma tumor suppressor domains [ 47969]


Superfamily statistics
Genomes (726) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 26,119 74,787 69
Proteins 16,157 45,966 37


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.03963Least InformativeInherited
Disease Ontology (DO)nervous system cancer0.007334Moderately InformativeInherited
Disease Ontology (DO)respiratory system cancer0.007257InformativeInherited
Disease Ontology (DO)retinal cell cancer0.000000004332Highly InformativeDirect
Disease Ontology (DO)laryngeal carcinoma0.000008157Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the respiratory system0.005027Moderately InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging0.00004143Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0.03769Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body region phenotype0.2353Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.2389Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.4884Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.861Least InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.002638Moderately InformativeInherited
Mammalian Phenotype (MP)neoplasm0.002722Moderately InformativeInherited
Mammalian Phenotype (MP)embryo phenotype0.03467Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.04728Moderately InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.08482Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.1285Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.1367Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.187Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system physiology0.199Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal myeloid cell morphology0.2396Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.2649Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.2933Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.4997Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.5762Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.7627Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.7932Moderately InformativeInherited
Mammalian Phenotype (MP)increased carcinoma incidence0.003549InformativeInherited
Mammalian Phenotype (MP)abnormal metencephalon morphology0.005009InformativeInherited
Mammalian Phenotype (MP)abnormal prenatal growth/weight/body size0.01248InformativeInherited
Mammalian Phenotype (MP)abnormal retinal neuronal layer morphology0.02003InformativeInherited
Mammalian Phenotype (MP)abnormal erythroid lineage cell morphology0.03065InformativeInherited
Mammalian Phenotype (MP)abnormal urine homeostasis0.04774InformativeInherited
Mammalian Phenotype (MP)abnormal eye physiology0.13InformativeInherited
Mammalian Phenotype (MP)abnormal appendicular skeleton morphology0.2894InformativeInherited
Mammalian Phenotype (MP)abnormal sensory neuron morphology0.4642InformativeInherited
Mammalian Phenotype (MP)abnormal neuron number0.564InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic stem cell morphology0.0003409Highly InformativeDirect
Mammalian Phenotype (MP)abnormal bone marrow cell morphology/development0.0006156Highly InformativeDirect
Mammalian Phenotype (MP)increased urinary system tumor incidence0.0008018Highly InformativeDirect
Mammalian Phenotype (MP)abnormal myeloid cell number0.007764Highly InformativeInherited
Mammalian Phenotype (MP)abnormal embryo size0.009431Highly InformativeInherited
Mammalian Phenotype (MP)abnormal retinal ganglion cell morphology0.01274Highly InformativeInherited
Mammalian Phenotype (MP)decreased sensory neuron number0.01762Highly InformativeInherited
Mammalian Phenotype (MP)abnormal fibroblast proliferation0.07761Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.002064Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.1062Least InformativeInherited
Worm Phenotype (WP)cell morphology variant0.1907Least InformativeInherited
Worm Phenotype (WP)retarded heterochronic variations1Least InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.000004231Moderately InformativeDirect
Worm Phenotype (WP)protein expression variant0.01237Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.08881Moderately InformativeInherited
Worm Phenotype (WP)reproductive system development variant0.09736Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.1296Moderately InformativeInherited
Worm Phenotype (WP)cell component morphology variant0.1628Moderately InformativeInherited
Worm Phenotype (WP)pigmentation variant0.00009236InformativeDirect
Worm Phenotype (WP)chromosome segregation variant0.000173InformativeDirect
Worm Phenotype (WP)embryonic cell organization biogenesis variant0.0005091InformativeDirect
Worm Phenotype (WP)somatic gonad development variant0.0006064InformativeDirect
Worm Phenotype (WP)protein modification variant0.09396InformativeInherited
Worm Phenotype (WP)cell number increased0.7312InformativeInherited
Worm Phenotype (WP)cell cycle variant0.0001659Highly InformativeDirect
Worm Phenotype (WP)slow embryonic development0.0001779Highly InformativeDirect
Worm Phenotype (WP)protein phosphorylation variant0.0003479Highly InformativeDirect
Worm Phenotype (WP)cytoplasmic appearance defective early emb0.03197Highly InformativeInherited
Worm Phenotype (WP)pronucleus centrosomes defective early emb0.177Highly InformativeInherited
Worm Phenotype (WP)multiple nuclei0.9491Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)morphology0.09924Moderately InformativeInherited
Yeast Phenotype (YP)subcellular morphology0.000461InformativeDirect
Yeast Phenotype (YP)budding0.02309Highly InformativeInherited

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)cell cycle defective0.00107InformativeInherited
Fly Phenotype (FP)mitotic cell cycle defective0.00006743Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)germline cell0.08899InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)nervous system0.318Least InformativeInherited
Zebrafish Anatomy (ZA)multi-tissue structure0.3496Least InformativeInherited
Zebrafish Anatomy (ZA)compound organ0.3891Least InformativeInherited
Zebrafish Anatomy (ZA)central nervous system0.01919Moderately InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.5411Moderately InformativeInherited
Zebrafish Anatomy (ZA)forebrain0.1402InformativeInherited
Zebrafish Anatomy (ZA)cranial nerve II0.0004124Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect
Xenopus ANatomical entity (XAN)embryo0.004949Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.01719Least InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.001782Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.5412Moderately InformativeInherited
Xenopus ANatomical entity (XAN)animal hemisphere0.002826InformativeInherited
Xenopus ANatomical entity (XAN)animal pole0.0003404Highly InformativeDirect
Xenopus ANatomical entity (XAN)neural tube0.07311Highly InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0.606Least InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0.00000000227Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.00002359Moderately InformativeDirect
Enzyme Commission (EC)Histone acetyltransferase0.0000001205InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0.00000665InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Post-translational modificationCyclin0InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR011028 SSF47954 Protein matches
Abstract

This domain is also found as the core domain in transcription factor IIB (TFIIB) and in the retinoblastoma tumour suppressor.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 29 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Cyclin-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 29 hidden Markov models representing the Cyclin-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]