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DEATH domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   DEATH domain [ 47985]
Superfamily:   DEATH domain [ 47986] (4)
Families:   DEATH domain, DD [ 81312] (8)
  DEATH effector domain, DED [ 81388] (2)
  Caspase recruitment domain, CARD [ 81313] (5)
  Pyrin domain, PYD [ 101298] (2)


Superfamily statistics
Genomes (147) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 9,260 18,386 25
Proteins 8,457 16,713 25


Functional annotation
General category Processes_IC
Detailed category Cell cycle, Apoptosis

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biological regulation0.00030240Least InformativeDirect
Biological Process (BP)regulation of localization0.0000000073630.0003263Moderately InformativeDirect
Biological Process (BP)regulation of multicellular organismal process0.00024840.000000000000197Moderately InformativeDirect
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.068891Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.029031Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.000033621Moderately InformativeInherited
Biological Process (BP)regulation of molecular function0.0010470Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process0.13071Moderately InformativeInherited
Biological Process (BP)regulation of macromolecule biosynthetic process0.075271Moderately InformativeInherited
Biological Process (BP)regulation of response to stimulus0.01820.0000000000000874Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.00000016350.06007Moderately InformativeInherited
Biological Process (BP)regulation of signaling0.0051120.000009725Moderately InformativeInherited
Biological Process (BP)regulation of cell communication0.0092490.000008136Moderately InformativeInherited
Biological Process (BP)regulation of cytokine production0.00000000011150InformativeDirect
Biological Process (BP)negative regulation of signaling0.00043850.000771InformativeDirect
Biological Process (BP)regulation of cellular component biogenesis0.00031520.02429InformativeInherited
Biological Process (BP)regulation of protein localization0.0057840.001299InformativeInherited
Biological Process (BP)negative regulation of response to stimulus0.0017450.5408InformativeInherited
Biological Process (BP)regulation of secretion0.019290.0007347InformativeInherited
Biological Process (BP)negative regulation of molecular function0.000000058351InformativeInherited
Biological Process (BP)negative regulation of multicellular organismal process0.000021210.4362InformativeInherited
Biological Process (BP)negative regulation of cellular component organization0.0030050.8968InformativeInherited
Biological Process (BP)regulation of peptide transport0.015530.000000188InformativeInherited
Biological Process (BP)negative regulation of cell communication0.00075920.00182InformativeInherited
Biological Process (BP)regulation of interleukin-1 production0.0000000000000031440.0000000031Highly InformativeDirect
Biological Process (BP)regulation of cytokine secretion0.00000000000016170.0002061Highly InformativeDirect
Biological Process (BP)negative regulation of protein complex assembly0.0000000019310.0001909Highly InformativeDirect
Biological Process (BP)negative regulation of sequence-specific DNA binding transcription factor activity0.000011030.0000005177Highly InformativeDirect
Biological Process (BP)negative regulation of cytokine production0.00000000000028820.2856Highly InformativeInherited
Molecular Function (MF)binding0.016140Least InformativeInherited
Molecular Function (MF)enzyme binding0.00033940.0000003531InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.0000000000002603 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.0000000000027 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.0000006335 Least Informative Direct
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 0.2913 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 0.2746 Least Informative Inherited
Biological Process (BP) regulation of localization 0.0003263 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.000000000000197 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 0 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.0000006323 Moderately Informative Direct
Biological Process (BP) regulation of signaling 0.000009725 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 0.000008136 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0.0000000000000874 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0 Moderately Informative Direct
Biological Process (BP) response to biotic stimulus 0 Moderately Informative Direct
Biological Process (BP) cell communication 0 Moderately Informative Direct
Biological Process (BP) multi-organism process 0 Moderately Informative Direct
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) single organism signaling 0 Moderately Informative Direct
Biological Process (BP) defense response 0 Moderately Informative Direct
Biological Process (BP) protein complex biogenesis 0.00000000000001079 Moderately Informative Direct
Biological Process (BP) response to external stimulus 0.0000000004819 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 0.000000448 Moderately Informative Direct
Biological Process (BP) cellular component assembly 0.00002242 Moderately Informative Direct
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.06007 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.308 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.008404 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.4733 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.02076 Moderately Informative Inherited
Biological Process (BP) gene expression 0.9074 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.866 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.004049 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) animal organ development 0.7528 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.5221 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) regulation of cytokine production 0 Informative Direct
Biological Process (BP) negative regulation of signaling 0.000771 Informative Direct
Biological Process (BP) regulation of peptide transport 0.000000188 Informative Direct
Biological Process (BP) regulation of secretion 0.0007347 Informative Direct
Biological Process (BP) cell death 0 Informative Direct
Biological Process (BP) regulation of proteolysis 0 Informative Direct
Biological Process (BP) regulation of immune response 0 Informative Direct
Biological Process (BP) positive regulation of immune system process 0 Informative Direct
Biological Process (BP) positive regulation of cellular protein metabolic process 0.000000000000001925 Informative Direct
Biological Process (BP) regulation of phosphorylation 0.00000000000002769 Informative Direct
Biological Process (BP) regulation of defense response 0.00000000000939 Informative Direct
Biological Process (BP) negative regulation of cell death 0.00000000003763 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0.00000000006911 Informative Direct
Biological Process (BP) generation of neurons 0.000000002774 Informative Direct
Biological Process (BP) cell activation 0.0000000104 Informative Direct
Biological Process (BP) immune response 0.00000002044 Informative Direct
Biological Process (BP) response to bacterium 0.00000002973 Informative Direct
Biological Process (BP) regulation of hydrolase activity 0.000000067 Informative Direct
Biological Process (BP) protein oligomerization 0.00000118 Informative Direct
Biological Process (BP) proteolysis 0.000007503 Informative Direct
Biological Process (BP) regulation of intracellular signal transduction 0.00000963 Informative Direct
Biological Process (BP) intracellular signal transduction 0.000146 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.0001619 Informative Direct
Biological Process (BP) regulation of transmembrane transport 0.5659 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.006496 Informative Inherited
Biological Process (BP) regulation of locomotion 0.01017 Informative Inherited
Biological Process (BP) localization of cell 0.3244 Informative Inherited
Biological Process (BP) growth 0.09233 Informative Inherited
Biological Process (BP) supramolecular fiber organization 0.004917 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) regulation of cell differentiation 1 Informative Inherited
Biological Process (BP) negative regulation of gene expression 1 Informative Inherited
Biological Process (BP) negative regulation of cellular protein metabolic process 1 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 0.002179 Informative Inherited
Biological Process (BP) single-organism cellular localization 0.3146 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.06932 Informative Inherited
Biological Process (BP) cellular response to lipid 0.1772 Informative Inherited
Biological Process (BP) cell development 0.3446 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.5408 Informative Inherited
Biological Process (BP) phosphorylation 0.05339 Informative Inherited
Biological Process (BP) regulation of protein localization 0.001299 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.00182 Informative Inherited
Biological Process (BP) positive regulation of transport 0.5615 Informative Inherited
Biological Process (BP) positive regulation of developmental process 1 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.009233 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.02429 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.07697 Informative Inherited
Biological Process (BP) regulation of growth 0.5573 Informative Inherited
Biological Process (BP) negative regulation of molecular function 1 Informative Inherited
Biological Process (BP) response to nitrogen compound 0.06974 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.7991 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.1254 Informative Inherited
Biological Process (BP) regulation of ion transport 1 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.01842 Informative Inherited
Biological Process (BP) defense response to other organism 0.01793 Informative Inherited
Biological Process (BP) immune effector process 1 Informative Inherited
Biological Process (BP) response to radiation 1 Informative Inherited
Biological Process (BP) locomotion 0.05515 Informative Inherited
Biological Process (BP) movement of cell or subcellular component 0.8829 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.4362 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.1658 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.203 Informative Inherited
Biological Process (BP) response to extracellular stimulus 1 Informative Inherited
Biological Process (BP) response to metal ion 0.1349 Informative Inherited
Biological Process (BP) regulation of protein modification process 1 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.8968 Informative Inherited
Biological Process (BP) interspecies interaction between organisms 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) regulation of catabolic process 0.4875 Informative Inherited
Biological Process (BP) cellular response to DNA damage stimulus 1 Informative Inherited
Biological Process (BP) system process 0.2825 Informative Inherited
Biological Process (BP) behavior 0.01372 Informative Inherited
Biological Process (BP) regulation of transferase activity 1 Informative Inherited
Biological Process (BP) single-organism membrane organization 0.4008 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.3491 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.00184 Informative Inherited
Biological Process (BP) hemopoiesis 0.4192 Informative Inherited
Biological Process (BP) embryo development 1 Informative Inherited
Biological Process (BP) epithelium development 0.2523 Informative Inherited
Biological Process (BP) circulatory system development 1 Informative Inherited
Biological Process (BP) regulation of interleukin-1 production 0.0000000031 Highly Informative Direct
Biological Process (BP) regulation of cytokine secretion 0.0002061 Highly Informative Direct
Biological Process (BP) negative regulation of protein complex assembly 0.0001909 Highly Informative Direct
Biological Process (BP) negative regulation of sequence-specific DNA binding transcription factor activity 0.0000005177 Highly Informative Direct
Biological Process (BP) regulation of cysteine-type endopeptidase activity 0 Highly Informative Direct
Biological Process (BP) negative regulation of homeostatic process 0 Highly Informative Direct
Biological Process (BP) positive regulation of cytokine production 0 Highly Informative Direct
Biological Process (BP) positive regulation of sequence-specific DNA binding transcription factor activity 0 Highly Informative Direct
Biological Process (BP) regulation of cell killing 0 Highly Informative Direct
Biological Process (BP) positive regulation of proteolysis 0.00000000000002436 Highly Informative Direct
Biological Process (BP) positive regulation of leukocyte proliferation 0.000000000003404 Highly Informative Direct
Biological Process (BP) leukocyte differentiation 0.00000000000952 Highly Informative Direct
Biological Process (BP) response to molecule of bacterial origin 0.00000000004262 Highly Informative Direct
Biological Process (BP) activation of innate immune response 0.000000000528 Highly Informative Direct
Biological Process (BP) negative regulation of immune system process 0.000000002213 Highly Informative Direct
Biological Process (BP) positive regulation of apoptotic process 0.000000004255 Highly Informative Direct
Biological Process (BP) positive regulation of cell adhesion 0.00000001539 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 0.00000004243 Highly Informative Direct
Biological Process (BP) plasma membrane bounded cell projection organization 0.00000006621 Highly Informative Direct
Biological Process (BP) regulation of leukocyte migration 0.0000001133 Highly Informative Direct
Biological Process (BP) positive regulation of protein transport 0.0000001831 Highly Informative Direct
Biological Process (BP) apoptotic process 0.0000003962 Highly Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0.000000703 Highly Informative Direct
Biological Process (BP) regulation of apoptotic signaling pathway 0.000001288 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0.000003502 Highly Informative Direct
Biological Process (BP) killing of cells of other organism 0.000003961 Highly Informative Direct
Biological Process (BP) positive regulation of immune effector process 0.00001511 Highly Informative Direct
Biological Process (BP) protein maturation 0.00001842 Highly Informative Direct
Biological Process (BP) cytokine-mediated signaling pathway 0.00002786 Highly Informative Direct
Biological Process (BP) neuron development 0.00004547 Highly Informative Direct
Biological Process (BP) regulation of leukocyte mediated immunity 0.00009963 Highly Informative Direct
Biological Process (BP) developmental growth involved in morphogenesis 0.000147 Highly Informative Direct
Biological Process (BP) positive regulation of peptide secretion 0.0001796 Highly Informative Direct
Biological Process (BP) activation of protein kinase activity 0.0005099 Highly Informative Direct
Biological Process (BP) regulation of autophagy 0.0007476 Highly Informative Direct
Biological Process (BP) regulation of T cell activation 0.0009552 Highly Informative Direct
Biological Process (BP) regulation of transmembrane transporter activity 0.02215 Highly Informative Inherited
Biological Process (BP) positive regulation of transporter activity 0.2483 Highly Informative Inherited
Biological Process (BP) regulation of cation transmembrane transport 0.377 Highly Informative Inherited
Biological Process (BP) positive regulation of transmembrane transport 0.3795 Highly Informative Inherited
Biological Process (BP) positive regulation of ion transport 0.8643 Highly Informative Inherited
Biological Process (BP) positive regulation of cell migration 0.03299 Highly Informative Inherited
Biological Process (BP) regulation of protein modification by small protein conjugation or removal 0.005918 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 0.2726 Highly Informative Inherited
Biological Process (BP) leukocyte migration 0.236 Highly Informative Inherited
Biological Process (BP) negative regulation of endopeptidase activity 1 Highly Informative Inherited
Biological Process (BP) protein localization to membrane 0.02985 Highly Informative Inherited
Biological Process (BP) response to mechanical stimulus 0.003929 Highly Informative Inherited
Biological Process (BP) cellular response to organonitrogen compound 0.3846 Highly Informative Inherited
Biological Process (BP) negative regulation of apoptotic process 1 Highly Informative Inherited
Biological Process (BP) response to endoplasmic reticulum stress 0.04442 Highly Informative Inherited
Biological Process (BP) anatomical structure homeostasis 0.06129 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular component biogenesis 0.1176 Highly Informative Inherited
Biological Process (BP) positive regulation of nervous system development 0.7615 Highly Informative Inherited
Biological Process (BP) modification of morphology or physiology of other organism involved in symbiotic interaction 0.003825 Highly Informative Inherited
Biological Process (BP) MAPK cascade 1 Highly Informative Inherited
Biological Process (BP) immune response-activating signal transduction 0.03199 Highly Informative Inherited
Biological Process (BP) positive regulation of secretion by cell 0.002205 Highly Informative Inherited
Biological Process (BP) cell growth 0.001163 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.002198 Highly Informative Inherited
Biological Process (BP) positive regulation of lymphocyte activation 0.0417 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.1296 Highly Informative Inherited
Biological Process (BP) positive regulation of MAPK cascade 0.957 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.3039 Highly Informative Inherited
Biological Process (BP) regulation of hemopoiesis 0.8516 Highly Informative Inherited
Biological Process (BP) regulation of lymphocyte proliferation 0.03063 Highly Informative Inherited
Biological Process (BP) multi-organism cellular process 0.1007 Highly Informative Inherited
Biological Process (BP) response to virus 0.6897 Highly Informative Inherited
Biological Process (BP) cellular response to abiotic stimulus 0.001028 Highly Informative Inherited
Biological Process (BP) response to UV 0.01613 Highly Informative Inherited
Biological Process (BP) negative regulation of cytokine production 0.2856 Highly Informative Inherited
Biological Process (BP) response to nutrient levels 0.0599 Highly Informative Inherited
Biological Process (BP) cellular component assembly involved in morphogenesis 0.05103 Highly Informative Inherited
Biological Process (BP) lymphocyte activation 0.008483 Highly Informative Inherited
Biological Process (BP) viral process 0.00579 Highly Informative Inherited
Biological Process (BP) regulation of protein processing 1 Highly Informative Inherited
Biological Process (BP) single-organism behavior 0.007022 Highly Informative Inherited
Biological Process (BP) nervous system process 0.1416 Highly Informative Inherited
Biological Process (BP) positive regulation of protein serine/threonine kinase activity 0.001118 Highly Informative Inherited
Biological Process (BP) endomembrane system organization 0.3153 Highly Informative Inherited
Biological Process (BP) positive regulation of response to external stimulus 0.8995 Highly Informative Inherited
Biological Process (BP) regulation of humoral immune response 1 Highly Informative Inherited
Biological Process (BP) positive regulation of adaptive immune response based on somatic recombination of immune receptors b 0.003189 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.09906 Highly Informative Inherited
Biological Process (BP) tube morphogenesis 0.4036 Highly Informative Inherited
Biological Process (BP) angiogenesis 0.06329 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) hydrolase activity 0.05653 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) molecular function regulator 0.0006909 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.6833 Moderately Informative Inherited
Molecular Function (MF) structural molecule activity 0.01281 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.09299 Moderately Informative Inherited
Molecular Function (MF) enzyme binding 0.0000003531 Informative Direct
Molecular Function (MF) enzyme activator activity 0.000005091 Informative Direct
Molecular Function (MF) peptidase regulator activity 0.00004442 Informative Direct
Molecular Function (MF) amide binding 0.2214 Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0.001487 Informative Inherited
Molecular Function (MF) receptor binding 0.7526 Informative Inherited
Molecular Function (MF) signal transducer activity 0.006197 Informative Inherited
Molecular Function (MF) molecular transducer activity 0.03185 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.005153 Informative Inherited
Molecular Function (MF) kinase activity 0.01147 Informative Inherited
Molecular Function (MF) peptidase activity, acting on L-amino acid peptides 0.02855 Informative Inherited
Molecular Function (MF) protein domain specific binding 0 Highly Informative Direct
Molecular Function (MF) protease binding 0 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase activity 0 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase regulator activity involved in apoptotic process 0.000000000198 Highly Informative Direct
Molecular Function (MF) cytokine receptor binding 0.000000000356 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0.00007247 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0.313 Highly Informative Inherited
Molecular Function (MF) kinase binding 0.3367 Highly Informative Inherited
Molecular Function (MF) peptide binding 0.007329 Highly Informative Inherited
Molecular Function (MF) transmembrane signaling receptor activity 0.002248 Highly Informative Inherited
Molecular Function (MF) transcription factor activity, transcription factor binding 0.03434 Highly Informative Inherited
Cellular Component (CC) membrane 0.0000000001154 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.00000001079 Least Informative Direct
Cellular Component (CC) protein complex 0.3938 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.006025 Least Informative Inherited
Cellular Component (CC) cytosolic part 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.00000001481 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.0004034 Moderately Informative Direct
Cellular Component (CC) cell projection 0.0004773 Moderately Informative Direct
Cellular Component (CC) whole membrane 0.003327 Moderately Informative Inherited
Cellular Component (CC) intrinsic component of membrane 1 Moderately Informative Inherited
Cellular Component (CC) membrane protein complex 1 Moderately Informative Inherited
Cellular Component (CC) membrane region 0.0000000000003002 Informative Direct
Cellular Component (CC) plasma membrane region 0.00001009 Informative Direct
Cellular Component (CC) neuron projection 0.00004276 Informative Direct
Cellular Component (CC) plasma membrane bounded cell projection part 0.1399 Informative Inherited
Cellular Component (CC) plasma membrane protein complex 0.007476 Informative Inherited
Cellular Component (CC) presynapse 0.05384 Highly Informative Inherited
Cellular Component (CC) receptor complex 0.06484 Highly Informative Inherited
Cellular Component (CC) cell-cell junction 0.3434 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Cysteine endopeptidases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processImmunity0Moderately InformativeDirect
Biological processApoptosis0Moderately InformativeDirect
Biological processDifferentiation0.00003137Moderately InformativeDirect
Biological processHost-virus interaction0.0005588Moderately InformativeDirect
Biological processInflammatory response0InformativeDirect
Biological processInnate immunity0.000000000000002156InformativeDirect
Biological processBiological rhythms0.0000000194InformativeDirect
Cellular componentNucleus0.000000000002257Least InformativeDirect
Cellular componentCytoplasm0.0000000000085Least InformativeDirect
Cellular componentMembrane0.000004143Least InformativeDirect
Cellular componentCell junction0.0000004493Moderately InformativeDirect
Cellular componentCell projection0.00002282Moderately InformativeDirect
Cellular componentCytoskeleton0.00008144Moderately InformativeDirect
Cellular componentSynapse0.00000000001618InformativeDirect
Cellular componentSarcoplasmic reticulum0.00000003068Highly InformativeDirect
Coding sequence diversityPolymorphism0.0003289Moderately InformativeDirect
DiseaseAmyloidosis0.00000006537Highly InformativeDirect
DomainRepeat0Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainANK repeat0InformativeDirect
DomainLeucine-rich repeat0InformativeDirect
DomainImmunoglobulin domain0.0000000008966InformativeDirect
Molecular functionNucleotide-binding0.05143Least InformativeInherited
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationProtease0.000000000004658Moderately InformativeDirect
Post-translational modificationActivator0.00000163Moderately InformativeDirect
Post-translational modificationKinase0.1711Moderately InformativeInherited
Post-translational modificationThiol protease0InformativeDirect
Post-translational modificationCalmodulin-binding0.000000000004791InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0.000000003965InformativeDirect
Post-translational modificationPhosphoprotein0.0000000000001081Least InformativeDirect
Post-translational modificationUbl conjugation0.00000000787Moderately InformativeDirect
Post-translational modificationZymogen0.00000000007154InformativeDirect
Post-translational modificationHydroxylation0.0004997InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR011029 SSF47986 Protein matches
Abstract

The death domain (DD) is a conserved region of about 80 residues found on death receptors, and which is required for death signalling, as well as a variety of non-apoptotic functions [PubMed11828422, PubMed12655292]. Proteins containing this domain include the low affinity neurotrophin receptor p73, Fas, FADD (Fas-associated death domain protein), TNF-1 (tumour necrosis factor receptor-1), Pelle protein kinase, and the Tube adaptor protein [PubMed15226512].

The induction of apoptosis also relies on the presence of a second domain, called the death effector domain. The death effector domain (DED) occurs in proteins that regulate programmed cell death, including both pro- and anti-apoptotic proteins; many of these proteins are also involved in controlling cellular activation and proliferation pathways [PubMed12719729]. Proteins containing this domain include FADD (DED N-terminal, DD C-terminal), PEA-15 (phosphoproteins enriched in astrocytes 15kDa), caspases and FLIP.

The induction of apoptosis results in the activation of caspases, a family of aspartyl-specific cysteine proteases that are the main executioners of apoptosis. For example, the DED of FADD recruits two DED-containing caspases, caspase-8 and caspase-10, to form the death-inducing signal complex, which initiates apoptosis. Proteins containing the caspase recruitment domain (CARD) are involved in the recruitment and activation of caspases during apoptosis [PubMed12101092]. Other CARD proteins participate in NF-kappaB signalling pathways associated with innate or adaptive immune responses. Proteins containing CARD include Raidd, APAF-1 (apoptotic protease activating factor 1), procaspase 9 and iceberg (inhibitor of interleukin-1-beta generation).

The DD shows strong structural similarity to both DED and CARD. They all display a 6-helical closed bundle fold, with greek key topology and an internal psuedo two-fold symmetry. However, despite their overall similarity in topology, each domain forms specialised interactions, typically only with members of its own subfamily, for example DED with DED.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 18 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a DEATH domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 18 hidden Markov models representing the DEATH domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]