SUPERFAMILY 1.75 HMM library and genome assignments server

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DEATH domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   DEATH domain [ 47985]
Superfamily:   DEATH domain [ 47986] (4)
Families:   DEATH domain, DD [ 81312] (8)
  DEATH effector domain, DED [ 81388] (2)
  Caspase recruitment domain, CARD [ 81313] (5)
  Pyrin domain, PYD [ 101298] (2)


Superfamily statistics
Genomes (141) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 9,881 9,865 25
Proteins 8,717 8,797 25


Functional annotation
General category Processes_IC
Detailed category Cell cycle, Apoptosis

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus0.00000020750Least InformativeDirect
Biological Process (BP)regulation of cellular process0.0000004770.00003882Least InformativeDirect
Biological Process (BP)single-organism cellular process0.000019950Least InformativeDirect
Biological Process (BP)regulation of metabolic process0.67570.9278Least InformativeInherited
Biological Process (BP)positive regulation of cellular process0.000000000031670Moderately InformativeDirect
Biological Process (BP)regulation of multicellular organismal process0.000023290.00000000003661Moderately InformativeDirect
Biological Process (BP)regulation of localization0.00011670.000000000004813Moderately InformativeDirect
Biological Process (BP)regulation of cellular biosynthetic process0.0019890.001865Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.0024030.1869Moderately InformativeInherited
Biological Process (BP)regulation of macromolecule biosynthetic process0.12710.06091Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.00023110.00262Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.0000061451Moderately InformativeInherited
Biological Process (BP)positive regulation of response to stimulus0.091180Moderately InformativeInherited
Biological Process (BP)positive regulation of signal transduction0.00000015080.0003471InformativeDirect
Biological Process (BP)positive regulation of multicellular organismal process0.00000099440InformativeDirect
Biological Process (BP)regulation of cytokine production0.0000062850InformativeDirect
Biological Process (BP)defense response0.000085540InformativeDirect
Biological Process (BP)regulation of protein localization0.0081730.01585InformativeInherited
Biological Process (BP)positive regulation of transport0.00017630.008105InformativeInherited
Biological Process (BP)regulation of secretion0.030320.03416InformativeInherited
Biological Process (BP)positive regulation of cytokine production00Highly InformativeDirect
Biological Process (BP)regulation of interleukin-1 beta production0.00000000000004210Highly InformativeDirect
Biological Process (BP)positive regulation of protein secretion0.0000046770.0000000000001302Highly InformativeDirect
Biological Process (BP)regulation of cytokine secretion0.0030390.00291Highly InformativeInherited
Molecular Function (MF)binding0.00013340Least InformativeDirect
Molecular Function (MF)nucleic acid binding0.00018691Moderately InformativeInherited
Molecular Function (MF)DNA binding0.000012770.5771InformativeInherited
Molecular Function (MF)structure-specific DNA binding0.000000061960.05875Highly InformativeInherited
Cellular Component (CC)protein complex0.00061670Least InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.00003882 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.000000000000001938 Least Informative Direct
Biological Process (BP) protein metabolic process 0.000001878 Least Informative Direct
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.9278 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) positive regulation of cellular process 0 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.00000000003661 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.000000000004813 Moderately Informative Direct
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.0000009776 Moderately Informative Direct
Biological Process (BP) signal transduction 0.0000000000002613 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 0 Moderately Informative Direct
Biological Process (BP) multi-organism process 0 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0.0000000002302 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 0.000000005859 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0.0000007984 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.00001022 Moderately Informative Direct
Biological Process (BP) nervous system development 0.0007442 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 0.01549 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.08863 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.3902 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.1869 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.00262 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.06091 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.001865 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.1063 Moderately Informative Inherited
Biological Process (BP) organ development 0.7275 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.02755 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.07385 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.4878 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.02311 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) ion transport 0.9555 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.002898 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cofactor metabolic process 0.111 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.0003471 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0 Informative Direct
Biological Process (BP) regulation of cytokine production 0 Informative Direct
Biological Process (BP) defense response 0 Informative Direct
Biological Process (BP) regulation of apoptotic signaling pathway 0.0000001655 Informative Direct
Biological Process (BP) response to cytokine stimulus 0 Informative Direct
Biological Process (BP) immune response 0 Informative Direct
Biological Process (BP) intracellular signal transduction 0.0001429 Informative Direct
Biological Process (BP) regulation of peptidase activity 0 Informative Direct
Biological Process (BP) positive regulation of immune system process 0 Informative Direct
Biological Process (BP) regulation of immune response 0 Informative Direct
Biological Process (BP) generation of neurons 0 Informative Direct
Biological Process (BP) response to bacterium 0 Informative Direct
Biological Process (BP) regulation of cell activation 0 Informative Direct
Biological Process (BP) regulation of defense response 0.000000000000001938 Informative Direct
Biological Process (BP) locomotion 0.000000000000169 Informative Direct
Biological Process (BP) regulation of intracellular protein kinase cascade 0.00000000003607 Informative Direct
Biological Process (BP) hematopoietic or lymphoid organ development 0.0000000003782 Informative Direct
Biological Process (BP) protein oligomerization 0.0000000004136 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.000000002815 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.00000002368 Informative Direct
Biological Process (BP) cell projection organization 0.0000001555 Informative Direct
Biological Process (BP) regulation of locomotion 0.000000258 Informative Direct
Biological Process (BP) positive regulation of phosphate metabolic process 0.0000003557 Informative Direct
Biological Process (BP) positive regulation of protein metabolic process 0.000001185 Informative Direct
Biological Process (BP) protein transport 0.000001639 Informative Direct
Biological Process (BP) negative regulation of cell death 0.000003855 Informative Direct
Biological Process (BP) blood circulation 0.00001011 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0.00001503 Informative Direct
Biological Process (BP) muscle system process 0.00004803 Informative Direct
Biological Process (BP) proteolysis 0.0002113 Informative Direct
Biological Process (BP) regulation of immune effector process 0.0004664 Informative Direct
Biological Process (BP) regulation of nervous system development 0.178 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 1 Informative Inherited
Biological Process (BP) negative regulation of gene expression 1 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 1 Informative Inherited
Biological Process (BP) apoptotic process 0.1427 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.07938 Informative Inherited
Biological Process (BP) cellular membrane organization 0.1982 Informative Inherited
Biological Process (BP) tube development 0.3009 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.8321 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 1 Informative Inherited
Biological Process (BP) response to organonitrogen compound 0.01258 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.07648 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.8044 Informative Inherited
Biological Process (BP) multi-multicellular organism process 0.9958 Informative Inherited
Biological Process (BP) cation homeostasis 0.02423 Informative Inherited
Biological Process (BP) positive regulation of developmental process 1 Informative Inherited
Biological Process (BP) regulation of protein localization 0.01585 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.002195 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.008914 Informative Inherited
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) synaptic transmission 0.7892 Informative Inherited
Biological Process (BP) regulation of vesicle-mediated transport 0.6685 Informative Inherited
Biological Process (BP) positive regulation of transport 0.008105 Informative Inherited
Biological Process (BP) regulation of secretion 0.03416 Informative Inherited
Biological Process (BP) muscle structure development 0.001151 Informative Inherited
Biological Process (BP) muscle tissue development 0.003753 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 1 Informative Inherited
Biological Process (BP) phosphorylation 0.08419 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.3046 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.02818 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.9915 Informative Inherited
Biological Process (BP) response to organic cyclic compound 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) organ morphogenesis 1 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.5387 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.05007 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.3314 Informative Inherited
Biological Process (BP) cellular component movement 0.009359 Informative Inherited
Biological Process (BP) localization of cell 0.7609 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.7746 Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.00355 Informative Inherited
Biological Process (BP) regulation of ion transport 0.9777 Informative Inherited
Biological Process (BP) response to nutrient levels 0.4888 Informative Inherited
Biological Process (BP) response to lipid 0.005925 Informative Inherited
Biological Process (BP) leukocyte activation 0.4402 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 1 Informative Inherited
Biological Process (BP) response to light stimulus 0.2159 Informative Inherited
Biological Process (BP) secretion by cell 0.9778 Informative Inherited
Biological Process (BP) response to DNA damage stimulus 0.2315 Informative Inherited
Biological Process (BP) regulation of cell development 0.02222 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.5149 Informative Inherited
Biological Process (BP) regulation of growth 0.2581 Informative Inherited
Biological Process (BP) single-organism behavior 0.0274 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.09374 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.9506 Informative Inherited
Biological Process (BP) fatty acid metabolic process 0.5266 Informative Inherited
Biological Process (BP) immune effector process 1 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) embryonic morphogenesis 1 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.01073 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0 Highly Informative Direct
Biological Process (BP) regulation of interleukin-1 beta production 0 Highly Informative Direct
Biological Process (BP) positive regulation of protein secretion 0.0000000000001302 Highly Informative Direct
Biological Process (BP) positive regulation of apoptotic signaling pathway 0.000000000000001938 Highly Informative Direct
Biological Process (BP) positive regulation of defense response 0 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0 Highly Informative Direct
Biological Process (BP) positive regulation of sequence-specific DNA binding transcription factor activity 0 Highly Informative Direct
Biological Process (BP) response to lipopolysaccharide 0 Highly Informative Direct
Biological Process (BP) neuron projection development 0 Highly Informative Direct
Biological Process (BP) regulation of mononuclear cell proliferation 0 Highly Informative Direct
Biological Process (BP) positive regulation of leukocyte proliferation 0 Highly Informative Direct
Biological Process (BP) execution phase of apoptosis 0 Highly Informative Direct
Biological Process (BP) extrinsic apoptotic signaling pathway 0 Highly Informative Direct
Biological Process (BP) heart contraction 0.0000000000005703 Highly Informative Direct
Biological Process (BP) positive regulation of cell activation 0.000000000001642 Highly Informative Direct
Biological Process (BP) positive regulation of endopeptidase activity 0.000000000001735 Highly Informative Direct
Biological Process (BP) striated muscle contraction 0.000000000002472 Highly Informative Direct
Biological Process (BP) regulation of cysteine-type endopeptidase activity involved in apoptotic process 0.0000000003961 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 0.000000000617 Highly Informative Direct
Biological Process (BP) cell part morphogenesis 0.000000001105 Highly Informative Direct
Biological Process (BP) regulation of toll-like receptor signaling pathway 0.000000001316 Highly Informative Direct
Biological Process (BP) leukocyte homeostasis 0.000000002539 Highly Informative Direct
Biological Process (BP) regulation of striated muscle cell differentiation 0.000000002594 Highly Informative Direct
Biological Process (BP) regulation of cytokine biosynthetic process 0.000000006968 Highly Informative Direct
Biological Process (BP) cytokine-mediated signaling pathway 0.00000001261 Highly Informative Direct
Biological Process (BP) hair follicle development 0.00000004015 Highly Informative Direct
Biological Process (BP) regulation of striated muscle tissue development 0.00000007331 Highly Informative Direct
Biological Process (BP) porphyrin-containing compound biosynthetic process 0.00000009104 Highly Informative Direct
Biological Process (BP) regulation of transmembrane transport 0.0000002999 Highly Informative Direct
Biological Process (BP) chemotaxis 0.0000003385 Highly Informative Direct
Biological Process (BP) regulation of membrane potential 0.0000007002 Highly Informative Direct
Biological Process (BP) defense response to bacterium 0.000001077 Highly Informative Direct
Biological Process (BP) learning or memory 0.000002427 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.000002911 Highly Informative Direct
Biological Process (BP) regulation of innate immune response 0.00000413 Highly Informative Direct
Biological Process (BP) regulation of transporter activity 0.000004901 Highly Informative Direct
Biological Process (BP) positive regulation of adaptive immune response 0.00001082 Highly Informative Direct
Biological Process (BP) myeloid cell development 0.00002454 Highly Informative Direct
Biological Process (BP) regulation of autophagy 0.00002931 Highly Informative Direct
Biological Process (BP) regulation of lymphocyte migration 0.00004685 Highly Informative Direct
Biological Process (BP) stress-activated protein kinase signaling cascade 0.000128 Highly Informative Direct
Biological Process (BP) regulation of multi-organism process 0.0001445 Highly Informative Direct
Biological Process (BP) response to UV 0.0002413 Highly Informative Direct
Biological Process (BP) morphogenesis of embryonic epithelium 0.0003298 Highly Informative Direct
Biological Process (BP) T cell differentiation 0.0004818 Highly Informative Direct
Biological Process (BP) positive regulation of lymphocyte mediated immunity 0.0005526 Highly Informative Direct
Biological Process (BP) negative regulation of sequence-specific DNA binding transcription factor activity 0.0005762 Highly Informative Direct
Biological Process (BP) transition metal ion homeostasis 0.000605 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.0006177 Highly Informative Direct
Biological Process (BP) monovalent inorganic cation transport 0.0008654 Highly Informative Direct
Biological Process (BP) epithelial tube formation 0.000906 Highly Informative Direct
Biological Process (BP) positive regulation of cell migration 0.3712 Highly Informative Inherited
Biological Process (BP) negative regulation of transcription, DNA-dependent 1 Highly Informative Inherited
Biological Process (BP) regulation of synaptic transmission 0.1996 Highly Informative Inherited
Biological Process (BP) regulation of behavior 1 Highly Informative Inherited
Biological Process (BP) cellular response to peptide 0.6947 Highly Informative Inherited
Biological Process (BP) negative regulation of apoptotic process 1 Highly Informative Inherited
Biological Process (BP) cell-type specific apoptotic process 0.162 Highly Informative Inherited
Biological Process (BP) female pregnancy 0.001817 Highly Informative Inherited
Biological Process (BP) sensory perception 0.004634 Highly Informative Inherited
Biological Process (BP) negative regulation of leukocyte activation 1 Highly Informative Inherited
Biological Process (BP) immune response-regulating cell surface receptor signaling pathway 0.1237 Highly Informative Inherited
Biological Process (BP) regulation of endocytosis 0.001119 Highly Informative Inherited
Biological Process (BP) regulation of cytokine secretion 0.00291 Highly Informative Inherited
Biological Process (BP) erythrocyte differentiation 0.0176 Highly Informative Inherited
Biological Process (BP) muscle fiber development 0.003753 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.01941 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 1 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 1 Highly Informative Inherited
Biological Process (BP) protein phosphorylation 0.01664 Highly Informative Inherited
Biological Process (BP) placenta development 0.09399 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 0.7473 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.492 Highly Informative Inherited
Biological Process (BP) regulation of organ morphogenesis 0.1338 Highly Informative Inherited
Biological Process (BP) regulation of protein catabolic process 0.2933 Highly Informative Inherited
Biological Process (BP) leukocyte migration 0.9503 Highly Informative Inherited
Biological Process (BP) immune response-activating signal transduction 0.01193 Highly Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.4371 Highly Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 1 Highly Informative Inherited
Biological Process (BP) positive regulation of MAPK cascade 0.9474 Highly Informative Inherited
Biological Process (BP) intrinsic apoptotic signaling pathway 0.03035 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.08663 Highly Informative Inherited
Biological Process (BP) MAPK cascade 0.9489 Highly Informative Inherited
Biological Process (BP) positive regulation of protein kinase activity 0.05607 Highly Informative Inherited
Biological Process (BP) cell junction organization 0.266 Highly Informative Inherited
Biological Process (BP) icosanoid metabolic process 0.001601 Highly Informative Inherited
Biological Process (BP) unsaturated fatty acid metabolic process 0.004648 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 0.01153 Highly Informative Inherited
Biological Process (BP) negative regulation of immune response 0.1699 Highly Informative Inherited
Biological Process (BP) regulation of adaptive immune response based on somatic recombination of immune receptors built from 0.231 Highly Informative Inherited
Biological Process (BP) regulation of production of molecular mediator of immune response 0.147 Highly Informative Inherited
Biological Process (BP) regulation of humoral immune response 0.4078 Highly Informative Inherited
Biological Process (BP) leukocyte mediated immunity 0.002246 Highly Informative Inherited
Biological Process (BP) response to fungus 0.7041 Highly Informative Inherited
Biological Process (BP) positive regulation of leukocyte mediated cytotoxicity 0.3056 Highly Informative Inherited
Biological Process (BP) neural tube development 0.002131 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) transferase activity 0.8335 Least Informative Inherited
Molecular Function (MF) hydrolase activity 0.003708 Least Informative Inherited
Molecular Function (MF) enzyme regulator activity 0.0008309 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.003573 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 1 Moderately Informative Inherited
Molecular Function (MF) peptidase activity 0 Informative Direct
Molecular Function (MF) enzyme activator activity 0.00000000001301 Informative Direct
Molecular Function (MF) peptidase regulator activity 0.000006395 Informative Direct
Molecular Function (MF) receptor activity 0.00001254 Informative Direct
Molecular Function (MF) molecular transducer activity 0.00001416 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.0002199 Informative Direct
Molecular Function (MF) kinase activity 0.000232 Informative Direct
Molecular Function (MF) enzyme binding 0.0007135 Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.3928 Informative Inherited
Molecular Function (MF) amide binding 0.009447 Informative Inherited
Molecular Function (MF) receptor binding 0.4318 Informative Inherited
Molecular Function (MF) DNA binding 0.5771 Informative Inherited
Molecular Function (MF) cytokine receptor binding 0 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase regulator activity involved in apoptotic process 0.000000000005459 Highly Informative Direct
Molecular Function (MF) channel regulator activity 0.0000000001302 Highly Informative Direct
Molecular Function (MF) endopeptidase activity 0.0000000002515 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0.0000000004613 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0.000004708 Highly Informative Direct
Molecular Function (MF) peptide binding 0.00001367 Highly Informative Direct
Molecular Function (MF) growth factor receptor binding 0.00002537 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0.8842 Highly Informative Inherited
Molecular Function (MF) kinase binding 0.2209 Highly Informative Inherited
Molecular Function (MF) transcription factor binding transcription factor activity 0.07056 Highly Informative Inherited
Molecular Function (MF) structure-specific DNA binding 0.05875 Highly Informative Inherited
Cellular Component (CC) protein complex 0 Least Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.0002382 Least Informative Direct
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.04499 Least Informative Inherited
Cellular Component (CC) cytosol 0.000000000002096 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.00000000001565 Moderately Informative Direct
Cellular Component (CC) cell projection 0.0000001976 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 1 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.0424 Moderately Informative Inherited
Cellular Component (CC) neuron projection 0.000000002336 Informative Direct
Cellular Component (CC) synapse part 0.0000006728 Informative Direct
Cellular Component (CC) contractile fiber part 0.0000009149 Informative Direct
Cellular Component (CC) cell junction 0.00007227 Informative Direct
Cellular Component (CC) integral to membrane 0.8187 Informative Inherited
Cellular Component (CC) cell cortex 0.102 Informative Inherited
Cellular Component (CC) cell-cell contact zone 0 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 0.0000002857 Highly Informative Direct
Cellular Component (CC) cortical cytoskeleton 0.0003874 Highly Informative Direct
Cellular Component (CC) main axon 0.001234 Highly Informative Inherited
Cellular Component (CC) receptor complex 0.07203 Highly Informative Inherited
Cellular Component (CC) sarcomere 0.0631 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Cysteine endopeptidases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.05614Least InformativeInherited
Disease Ontology (DO)connective tissue disease0.003192Moderately InformativeInherited
Disease Ontology (DO)syndrome0.04052Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.9848Moderately InformativeInherited
Disease Ontology (DO)inflammatory bowel disease0.000001253InformativeDirect
Disease Ontology (DO)arthropathy0.01522InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type IV disease0.03207InformativeInherited
Disease Ontology (DO)viral infectious disease1InformativeInherited
Disease Ontology (DO)irritable bowel syndrome0.00001074Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

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HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the abdomen0.2385Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.3783Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.787Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.7879Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.002352Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the immune system0.005298Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.145Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiac morphology0.6229Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.6633Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of temperature regulation0.0000003942InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the spleen0.0004608InformativeDirect
Phenotypic Abnormality (PA)Visceromegaly0.002475InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lymph nodes0.004708InformativeInherited
Phenotypic Abnormality (PA)Abnormality of leukocytes0.06816InformativeInherited
Phenotypic Abnormality (PA)Vasculitis0.00000002389Highly InformativeDirect
Phenotypic Abnormality (PA)Lymphadenopathy0.0000007304Highly InformativeDirect
Phenotypic Abnormality (PA)Leukocytosis0.00001488Highly InformativeDirect
Phenotypic Abnormality (PA)Episodic fever0.00002424Highly InformativeDirect
Phenotypic Abnormality (PA)Elevated erythrocyte sedimentation rate0.00002625Highly InformativeDirect
Phenotypic Abnormality (PA)Increased IgM level0.00009769Highly InformativeDirect
Phenotypic Abnormality (PA)Amyloidosis0.0001131Highly InformativeDirect
Phenotypic Abnormality (PA)Meningitis0.0001916Highly InformativeDirect
Phenotypic Abnormality (PA)Arthralgia0.0005109Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the pericardium0.0005476Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of T cell physiology0.0005476Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the peritoneum0.0008595Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

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MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype0.0000002491Least InformativeDirect
Mammalian Phenotype (MP)immune system phenotype0.0000007287Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0.0000786Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0.2374Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.4803Least InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell physiology0.00000000001416Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal protein level0.0000006609Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.0000009165Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal immune cell physiology0.0005792Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cell-mediated immunity0.0007019Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal adaptive immunity0.001031Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.002191Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.01155Moderately InformativeInherited
Mammalian Phenotype (MP)digestive/alimentary phenotype0.08633Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukopoiesis0.1018Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.1421Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.3097Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.4834Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal macrophage physiology0.0002829InformativeDirect
Mammalian Phenotype (MP)autoimmune response0.000338InformativeDirect
Mammalian Phenotype (MP)abnormal phagocyte morphology0.0003748InformativeDirect
Mammalian Phenotype (MP)abnormal circulating cytokine level0.001523InformativeInherited
Mammalian Phenotype (MP)abnormal lymph node morphology0.01194InformativeInherited
Mammalian Phenotype (MP)abnormal spleen morphology0.01283InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin secretion0.02275InformativeInherited
Mammalian Phenotype (MP)abnormal T cell physiology0.1215InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system physiology0.1636InformativeInherited
Mammalian Phenotype (MP)abnormal mature B cell morphology0.1981InformativeInherited
Mammalian Phenotype (MP)abnormal interferon secretion0.2246InformativeInherited
Mammalian Phenotype (MP)abnormal interferon level0.3054InformativeInherited
Mammalian Phenotype (MP)abnormal respiration0.3673InformativeInherited
Mammalian Phenotype (MP)abnormal T cell morphology0.7252InformativeInherited
Mammalian Phenotype (MP)abnormal Peyer's patch morphology0.8425InformativeInherited
Mammalian Phenotype (MP)abnormal lymph organ size0.8934InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin-1 beta secretion0.00000000008105Highly InformativeDirect
Mammalian Phenotype (MP)abnormal Peyer's patch size0.0000002771Highly InformativeDirect
Mammalian Phenotype (MP)enlarged lymph nodes0.00000144Highly InformativeDirect
Mammalian Phenotype (MP)decreased interferon-alpha secretion0.000003178Highly InformativeDirect
Mammalian Phenotype (MP)abnormal spleen germinal center morphology0.00002707Highly InformativeDirect
Mammalian Phenotype (MP)abnormal gut flora balance0.00006613Highly InformativeDirect
Mammalian Phenotype (MP)abnormal B-1 B cell number0.00008105Highly InformativeDirect
Mammalian Phenotype (MP)decreased apoptosis0.0001036Highly InformativeDirect
Mammalian Phenotype (MP)abnormal airway responsiveness0.0001407Highly InformativeDirect
Mammalian Phenotype (MP)abnormal acute inflammation0.0002809Highly InformativeDirect
Mammalian Phenotype (MP)abnormal T cell proliferation0.0004386Highly InformativeDirect
Mammalian Phenotype (MP)decreased inflammatory response0.0004808Highly InformativeDirect
Mammalian Phenotype (MP)abnormal interleukin-6 secretion0.06368Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

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WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.0001952Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.003962Least InformativeInherited
Worm Phenotype (WP)cell death variant0.05475Moderately InformativeInherited
Worm Phenotype (WP)cell corpse number variant0.00004879InformativeDirect
Worm Phenotype (WP)transgene expression reduced0.0001888InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

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FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)immune response defective0.0008678Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

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FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect

Document: FA annotation of SCOP domains

Enzyme Commission (EC)

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EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.0000002484Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorous-containing groups0.00001342Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect
Enzyme Commission (EC)Cysteine endopeptidases0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0.000443InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0.0000003838Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

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KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis0Moderately InformativeDirect
Biological processDifferentiation0.000009623Moderately InformativeDirect
Biological processInflammatory response0InformativeDirect
Biological processInnate immunity0.000000000001366InformativeDirect
Biological processBiological rhythms0.000000001549InformativeDirect
Biological processmRNA splicing0.0001428InformativeDirect
Cellular componentNucleus0.00000000001466Least InformativeDirect
Cellular componentCytoplasm0.0000002337Least InformativeDirect
Cellular componentMembrane0.00056Least InformativeDirect
Cellular componentCytoskeleton0.00006139Moderately InformativeDirect
Cellular componentCell junction0.007212Moderately InformativeInherited
Cellular componentSynapse0.06242InformativeInherited
Cellular componentPostsynaptic cell membrane0.00001825Highly InformativeDirect
Coding sequence diversityPolymorphism0.0005859Moderately InformativeDirect
DiseaseAmyloidosis0.00000008887Highly InformativeDirect
DomainRepeat0Least InformativeDirect
DomainTransmembrane0.9795Least InformativeInherited
DomainANK repeat0InformativeDirect
DomainLeucine-rich repeat0InformativeDirect
DomainImmunoglobulin domain0.00000001579InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationProtease0.000000000005135Moderately InformativeDirect
Post-translational modificationActivator0.0006637Moderately InformativeDirect
Post-translational modificationKinase0.1306Moderately InformativeInherited
Post-translational modificationThiol protease0InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0.000000001363InformativeDirect
Post-translational modificationPhosphoprotein0.0000000000008965Least InformativeDirect
Post-translational modificationUbl conjugation0.00000002308Moderately InformativeDirect
Post-translational modificationZymogen0.000000000007671InformativeDirect
Post-translational modificationHydroxylation0.000169InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR011029 SSF47986 Protein matches
Abstract

The death domain (DD) is a conserved region of about 80 residues found on death receptors, and which is required for death signalling, as well as a variety of non-apoptotic functions [PubMed11828422, PubMed12655292]. Proteins containing this domain include the low affinity neurotrophin receptor p73, Fas, FADD (Fas-associated death domain protein), TNF-1 (tumour necrosis factor receptor-1), Pelle protein kinase, and the Tube adaptor protein [PubMed15226512].

The induction of apoptosis also relies on the presence of a second domain, called the death effector domain. The death effector domain (DED) occurs in proteins that regulate programmed cell death, including both pro- and anti-apoptotic proteins; many of these proteins are also involved in controlling cellular activation and proliferation pathways [PubMed12719729]. Proteins containing this domain include FADD (DED N-terminal, DD C-terminal), PEA-15 (phosphoproteins enriched in astrocytes 15kDa), caspases and FLIP.

The induction of apoptosis results in the activation of caspases, a family of aspartyl-specific cysteine proteases that are the main executioners of apoptosis. For example, the DED of FADD recruits two DED-containing caspases, caspase-8 and caspase-10, to form the death-inducing signal complex, which initiates apoptosis. Proteins containing the caspase recruitment domain (CARD) are involved in the recruitment and activation of caspases during apoptosis [PubMed12101092]. Other CARD proteins participate in NF-kappaB signalling pathways associated with innate or adaptive immune responses. Proteins containing CARD include Raidd, APAF-1 (apoptotic protease activating factor 1), procaspase 9 and iceberg (inhibitor of interleukin-1-beta generation).

The DD shows strong structural similarity to both DED and CARD. They all display a 6-helical closed bundle fold, with greek key topology and an internal psuedo two-fold symmetry. However, despite their overall similarity in topology, each domain forms specialised interactions, typically only with members of its own subfamily, for example DED with DED.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 18 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a DEATH domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 18 hidden Markov models representing the DEATH domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]