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DEATH domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   DEATH domain [ 47985]
Superfamily:   DEATH domain [ 47986] (4)
Families:   DEATH domain, DD [ 81312] (8)
  DEATH effector domain, DED [ 81388] (2)
  Caspase recruitment domain, CARD [ 81313] (5)
  Pyrin domain, PYD [ 101298] (2)


Superfamily statistics
Genomes (144) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 9,186 9,865 25
Proteins 8,388 8,797 25


Functional annotation
General category Processes_IC
Detailed category Cell cycle, Apoptosis

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biological regulation0.0054860Least InformativeInherited
Biological Process (BP)regulation of localization0.0000033180.000129Moderately InformativeDirect
Biological Process (BP)regulation of multicellular organismal process0.0041710.00000000000008674Moderately InformativeInherited
Biological Process (BP)regulation of signaling0.0050710.000004121Moderately InformativeInherited
Biological Process (BP)regulation of cytokine production0.00000049980InformativeDirect
Biological Process (BP)regulation of establishment of protein localization0.0000016910.0006368InformativeDirect
Biological Process (BP)negative regulation of signaling0.00063350.00069InformativeDirect
Biological Process (BP)regulation of peptide transport0.066410.0000009109InformativeInherited
Biological Process (BP)regulation of secretion0.076060.00143InformativeInherited
Biological Process (BP)regulation of interleukin-1 production0.00000000040990.00000002561Highly InformativeDirect
Biological Process (BP)regulation of cytokine secretion0.0000000063840.0002366Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.0000000000001311 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.0000002191 Least Informative Direct
Biological Process (BP) macromolecule metabolic process 0.1696 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 0.1677 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of localization 0.000129 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 0 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.00000000000008674 Moderately Informative Direct
Biological Process (BP) regulation of signaling 0.000004121 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 0.000006099 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0.00000000000001958 Moderately Informative Direct
Biological Process (BP) single organism signaling 0 Moderately Informative Direct
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) response to biotic stimulus 0 Moderately Informative Direct
Biological Process (BP) multi-organism process 0 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0 Moderately Informative Direct
Biological Process (BP) cell communication 0 Moderately Informative Direct
Biological Process (BP) protein complex biogenesis 0 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0 Moderately Informative Direct
Biological Process (BP) response to external stimulus 0.000000001028 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 0.0000001152 Moderately Informative Direct
Biological Process (BP) system development 0.0000007472 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.00001708 Moderately Informative Direct
Biological Process (BP) cellular component assembly 0.0002467 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.00432 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.2836 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) single-organism transport 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.02388 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 0.006096 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.9556 Moderately Informative Inherited
Biological Process (BP) nitrogen compound transport 0.017 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.5897 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.7295 Moderately Informative Inherited
Biological Process (BP) gene expression 0.87 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.1279 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.001445 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.8718 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.01584 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.4562 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of cytokine production 0 Informative Direct
Biological Process (BP) regulation of establishment of protein localization 0.0006368 Informative Direct
Biological Process (BP) negative regulation of signaling 0.00069 Informative Direct
Biological Process (BP) regulation of peptide transport 0.0000009109 Informative Direct
Biological Process (BP) positive regulation of cell death 0 Informative Direct
Biological Process (BP) cell death 0 Informative Direct
Biological Process (BP) regulation of proteolysis 0 Informative Direct
Biological Process (BP) positive regulation of immune response 0 Informative Direct
Biological Process (BP) positive regulation of cellular protein metabolic process 0.000000000000001945 Informative Direct
Biological Process (BP) regulation of phosphorylation 0.000000000000007367 Informative Direct
Biological Process (BP) response to cytokine 0.0000000000003554 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0.000000000006838 Informative Direct
Biological Process (BP) negative regulation of cell death 0.00000000001199 Informative Direct
Biological Process (BP) regulation of defense response 0.00000000001748 Informative Direct
Biological Process (BP) generation of neurons 0.00000000009452 Informative Direct
Biological Process (BP) response to bacterium 0.000000005784 Informative Direct
Biological Process (BP) cell activation 0.000000006255 Informative Direct
Biological Process (BP) immune response 0.00000004417 Informative Direct
Biological Process (BP) regulation of hydrolase activity 0.00000012 Informative Direct
Biological Process (BP) protein oligomerization 0.000001193 Informative Direct
Biological Process (BP) regulation of intracellular signal transduction 0.00001727 Informative Direct
Biological Process (BP) cytoskeleton organization 0.00002382 Informative Direct
Biological Process (BP) proteolysis 0.00002602 Informative Direct
Biological Process (BP) intracellular signal transduction 0.00004705 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.000305 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.0008147 Informative Direct
Biological Process (BP) regulation of ion transport 1 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.5361 Informative Inherited
Biological Process (BP) movement of cell or subcellular component 0.6109 Informative Inherited
Biological Process (BP) growth 0.03764 Informative Inherited
Biological Process (BP) supramolecular fiber organization 0.002536 Informative Inherited
Biological Process (BP) regulation of cellular localization 1 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 1 Informative Inherited
Biological Process (BP) negative regulation of gene expression 1 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.9637 Informative Inherited
Biological Process (BP) regulation of cell differentiation 1 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.01799 Informative Inherited
Biological Process (BP) negative regulation of molecular function 1 Informative Inherited
Biological Process (BP) intracellular protein transport 0.2269 Informative Inherited
Biological Process (BP) single-organism intracellular transport 0.6558 Informative Inherited
Biological Process (BP) response to nitrogen compound 0.05036 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.233 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.1523 Informative Inherited
Biological Process (BP) interspecies interaction between organisms 1 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.08015 Informative Inherited
Biological Process (BP) phosphorylation 0.03325 Informative Inherited
Biological Process (BP) positive regulation of transport 0.4022 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.01848 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) regulation of growth 0.3662 Informative Inherited
Biological Process (BP) regulation of transcription, DNA-templated 0.014 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.8285 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.01472 Informative Inherited
Biological Process (BP) defense response to other organism 0.009573 Informative Inherited
Biological Process (BP) regulation of transmembrane transport 0.5075 Informative Inherited
Biological Process (BP) locomotion 0.01382 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.004489 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.1926 Informative Inherited
Biological Process (BP) regulation of transferase activity 1 Informative Inherited
Biological Process (BP) response to extracellular stimulus 1 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.9668 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 0.001946 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) regulation of catabolic process 0.3835 Informative Inherited
Biological Process (BP) cellular response to DNA damage stimulus 1 Informative Inherited
Biological Process (BP) behavior 0.006691 Informative Inherited
Biological Process (BP) system process 0.1823 Informative Inherited
Biological Process (BP) regulation of protein modification process 1 Informative Inherited
Biological Process (BP) membrane organization 0.9019 Informative Inherited
Biological Process (BP) regulation of secretion 0.00143 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.2706 Informative Inherited
Biological Process (BP) regulation of locomotion 0.004306 Informative Inherited
Biological Process (BP) immune effector process 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.6005 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.001819 Informative Inherited
Biological Process (BP) tissue development 1 Informative Inherited
Biological Process (BP) embryo development 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.359 Informative Inherited
Biological Process (BP) circulatory system development 1 Informative Inherited
Biological Process (BP) cell development 0.1339 Informative Inherited
Biological Process (BP) microtubule-based process 0.01673 Informative Inherited
Biological Process (BP) regulation of interleukin-1 production 0.00000002561 Highly Informative Direct
Biological Process (BP) regulation of cytokine secretion 0.0002366 Highly Informative Direct
Biological Process (BP) regulation of cysteine-type endopeptidase activity 0 Highly Informative Direct
Biological Process (BP) negative regulation of homeostatic process 0 Highly Informative Direct
Biological Process (BP) regulation of cell killing 0 Highly Informative Direct
Biological Process (BP) regulation of sequence-specific DNA binding transcription factor activity 0 Highly Informative Direct
Biological Process (BP) positive regulation of cytokine production 0 Highly Informative Direct
Biological Process (BP) positive regulation of proteolysis 0.00000000000003469 Highly Informative Direct
Biological Process (BP) positive regulation of leukocyte proliferation 0.000000000001971 Highly Informative Direct
Biological Process (BP) leukocyte differentiation 0.00000000002379 Highly Informative Direct
Biological Process (BP) activation of innate immune response 0.000000001376 Highly Informative Direct
Biological Process (BP) response to molecule of bacterial origin 0.000000001467 Highly Informative Direct
Biological Process (BP) plasma membrane bounded cell projection organization 0.000000001813 Highly Informative Direct
Biological Process (BP) positive regulation of cell adhesion 0.000000003161 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 0.00000001005 Highly Informative Direct
Biological Process (BP) negative regulation of immune system process 0.00000002288 Highly Informative Direct
Biological Process (BP) positive regulation of protein transport 0.00000003656 Highly Informative Direct
Biological Process (BP) regulation of leukocyte migration 0.0000000684 Highly Informative Direct
Biological Process (BP) apoptotic process 0.0000001738 Highly Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0.0000002376 Highly Informative Direct
Biological Process (BP) positive regulation of apoptotic process 0.0000002407 Highly Informative Direct
Biological Process (BP) regulation of apoptotic signaling pathway 0.000000617 Highly Informative Direct
Biological Process (BP) cytokine-mediated signaling pathway 0.0000009589 Highly Informative Direct
Biological Process (BP) protein maturation 0.000006078 Highly Informative Direct
Biological Process (BP) neuron development 0.0000129 Highly Informative Direct
Biological Process (BP) positive regulation of peptide secretion 0.00002465 Highly Informative Direct
Biological Process (BP) killing of cells of other organism 0.0000363 Highly Informative Direct
Biological Process (BP) developmental growth involved in morphogenesis 0.00005587 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0.000381 Highly Informative Direct
Biological Process (BP) cell growth 0.0006063 Highly Informative Direct
Biological Process (BP) activation of protein kinase activity 0.0006261 Highly Informative Direct
Biological Process (BP) regulation of autophagy 0.0008266 Highly Informative Direct
Biological Process (BP) regulation of leukocyte differentiation 0.0008649 Highly Informative Direct
Biological Process (BP) regulation of T cell activation 0.000903 Highly Informative Direct
Biological Process (BP) neutrophil mediated immunity 0.0009227 Highly Informative Direct
Biological Process (BP) microtubule cytoskeleton organization 0.0009421 Highly Informative Direct
Biological Process (BP) negative regulation of protein complex assembly 0.0009922 Highly Informative Direct
Biological Process (BP) regulation of transmembrane transporter activity 0.02087 Highly Informative Inherited
Biological Process (BP) positive regulation of transporter activity 0.2264 Highly Informative Inherited
Biological Process (BP) regulation of cation transmembrane transport 0.368 Highly Informative Inherited
Biological Process (BP) positive regulation of transmembrane transport 0.3774 Highly Informative Inherited
Biological Process (BP) positive regulation of ion transport 0.8636 Highly Informative Inherited
Biological Process (BP) positive regulation of cell migration 0.03432 Highly Informative Inherited
Biological Process (BP) leukocyte migration 0.2588 Highly Informative Inherited
Biological Process (BP) regulation of protein modification by small protein conjugation or removal 0.005594 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 0.2916 Highly Informative Inherited
Biological Process (BP) regulation of protein processing 1 Highly Informative Inherited
Biological Process (BP) negative regulation of endopeptidase activity 1 Highly Informative Inherited
Biological Process (BP) endomembrane system organization 0.3107 Highly Informative Inherited
Biological Process (BP) cellular response to abiotic stimulus 0.001538 Highly Informative Inherited
Biological Process (BP) response to mechanical stimulus 0.002367 Highly Informative Inherited
Biological Process (BP) cellular response to organonitrogen compound 0.3866 Highly Informative Inherited
Biological Process (BP) response to endoplasmic reticulum stress 0.03388 Highly Informative Inherited
Biological Process (BP) anatomical structure homeostasis 0.07069 Highly Informative Inherited
Biological Process (BP) viral process 0.01673 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular component biogenesis 0.06418 Highly Informative Inherited
Biological Process (BP) MAPK cascade 1 Highly Informative Inherited
Biological Process (BP) positive regulation of secretion by cell 0.001024 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.1826 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.1265 Highly Informative Inherited
Biological Process (BP) positive regulation of MAPK cascade 0.9035 Highly Informative Inherited
Biological Process (BP) regulation of lymphocyte proliferation 0.02877 Highly Informative Inherited
Biological Process (BP) positive regulation of nervous system development 0.6383 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.001451 Highly Informative Inherited
Biological Process (BP) lymphocyte activation 0.008722 Highly Informative Inherited
Biological Process (BP) positive regulation of lymphocyte activation 0.05771 Highly Informative Inherited
Biological Process (BP) multi-organism cellular process 0.07229 Highly Informative Inherited
Biological Process (BP) response to virus 0.7589 Highly Informative Inherited
Biological Process (BP) chemotaxis 0.2049 Highly Informative Inherited
Biological Process (BP) response to nutrient levels 0.06304 Highly Informative Inherited
Biological Process (BP) modification of morphology or physiology of other organism involved in symbiotic interaction 0.01008 Highly Informative Inherited
Biological Process (BP) single-organism behavior 0.003709 Highly Informative Inherited
Biological Process (BP) neurological system process 0.1271 Highly Informative Inherited
Biological Process (BP) positive regulation of protein serine/threonine kinase activity 0.001401 Highly Informative Inherited
Biological Process (BP) protein localization to membrane 0.02822 Highly Informative Inherited
Biological Process (BP) positive regulation of response to external stimulus 0.8626 Highly Informative Inherited
Biological Process (BP) regulation of humoral immune response 1 Highly Informative Inherited
Biological Process (BP) immune response-activating signal transduction 0.06533 Highly Informative Inherited
Biological Process (BP) positive regulation of lymphocyte mediated immunity 0.001597 Highly Informative Inherited
Biological Process (BP) positive regulation of adaptive immune response based on somatic recombination of immune receptors b 0.003114 Highly Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.007111 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.1253 Highly Informative Inherited
Biological Process (BP) tube morphogenesis 0.3941 Highly Informative Inherited
Biological Process (BP) angiogenesis 0.08909 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) hydrolase activity 0.09048 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) molecular function regulator 0.0007317 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.8362 Moderately Informative Inherited
Molecular Function (MF) structural molecule activity 0.1749 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.0542 Moderately Informative Inherited
Molecular Function (MF) enzyme activator activity 0.0000004171 Informative Direct
Molecular Function (MF) enzyme binding 0.0000006562 Informative Direct
Molecular Function (MF) peptidase regulator activity 0.0001422 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0.0006059 Informative Direct
Molecular Function (MF) peptidase activity, acting on L-amino acid peptides 0.04716 Informative Inherited
Molecular Function (MF) receptor binding 0.6795 Informative Inherited
Molecular Function (MF) molecular transducer activity 0.01602 Informative Inherited
Molecular Function (MF) signal transducer activity 0.002578 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.002505 Informative Inherited
Molecular Function (MF) kinase activity 0.005844 Informative Inherited
Molecular Function (MF) cysteine-type endopeptidase activity 0 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0 Highly Informative Direct
Molecular Function (MF) protease binding 0 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase regulator activity involved in apoptotic process 0.0000000001199 Highly Informative Direct
Molecular Function (MF) cytokine receptor binding 0.0000000004708 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0.00002795 Highly Informative Direct
Molecular Function (MF) transmembrane signaling receptor activity 0.0008474 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0.2202 Highly Informative Inherited
Molecular Function (MF) kinase binding 0.2778 Highly Informative Inherited
Molecular Function (MF) transcription factor activity, transcription factor binding 0.02426 Highly Informative Inherited
Cellular Component (CC) macromolecular complex 0 Least Informative Direct
Cellular Component (CC) membrane 0.0000000002337 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.000000004678 Least Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0.01945 Least Informative Inherited
Cellular Component (CC) cytosolic part 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.00000001773 Moderately Informative Direct
Cellular Component (CC) whole membrane 0.02346 Moderately Informative Inherited
Cellular Component (CC) intrinsic component of membrane 1 Moderately Informative Inherited
Cellular Component (CC) cell projection 0.001465 Moderately Informative Inherited
Cellular Component (CC) membrane protein complex 1 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.004368 Moderately Informative Inherited
Cellular Component (CC) membrane region 0.0000000002501 Informative Direct
Cellular Component (CC) synapse 0.000000004437 Informative Direct
Cellular Component (CC) plasma membrane region 0.000003885 Informative Direct
Cellular Component (CC) neuron projection 0.00005494 Informative Direct
Cellular Component (CC) plasma membrane bounded cell projection part 0.03901 Informative Inherited
Cellular Component (CC) plasma membrane protein complex 0.008381 Informative Inherited
Cellular Component (CC) cell body membrane 0.0005028 Highly Informative Direct
Cellular Component (CC) receptor complex 0.03896 Highly Informative Inherited
Cellular Component (CC) cell-cell junction 0.2665 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Cysteine endopeptidases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)disease by infectious agent0.00000007079Moderately InformativeDirect
Disease Ontology (DO)connective tissue disease0.002057Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.0113Moderately InformativeInherited
Disease Ontology (DO)syndrome0.05127Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.9745Moderately InformativeInherited
Disease Ontology (DO)inflammatory bowel disease0.000001177InformativeDirect
Disease Ontology (DO)arthropathy0.01605InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type IV disease0.03954InformativeInherited
Disease Ontology (DO)viral infectious disease1InformativeInherited
Disease Ontology (DO)irritable bowel syndrome0.000008854Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the immune system0.00007267Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the integument0.006268Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.04621Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.1787Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the face0.4377Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.4537Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.6515Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.7616Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.9162Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.9911Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.001755Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal inflammatory response0.008093Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.02562Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal respiratory system morphology0.02753Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.1297Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of humoral immunity0.1403Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the oral cavity0.4729Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.5487Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin adnexa morphology0.7704Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.8134Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal genital system morphology0.9424Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal vascular morphology0.00004316InformativeDirect
Phenotypic Abnormality (PA)Abnormality of oral mucosa0.00006184InformativeDirect
Phenotypic Abnormality (PA)CNS infection0.00009108InformativeDirect
Phenotypic Abnormality (PA)Abnormality of abdomen morphology0.000566InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the lymphatic system0.001257InformativeInherited
Phenotypic Abnormality (PA)Abnormal hair quantity0.06566InformativeInherited
Phenotypic Abnormality (PA)Abnormality of lymphocytes0.1779InformativeInherited
Phenotypic Abnormality (PA)Abnormality of bone marrow cell morphology0.4278InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the testis0.793InformativeInherited
Phenotypic Abnormality (PA)Lymphadenopathy0.000000002251Highly InformativeDirect
Phenotypic Abnormality (PA)Vasculitis0.00000001181Highly InformativeDirect
Phenotypic Abnormality (PA)Splenomegaly0.0000009472Highly InformativeDirect
Phenotypic Abnormality (PA)Inflammatory abnormality of the eye0.00001884Highly InformativeDirect
Phenotypic Abnormality (PA)Recurrent aphthous stomatitis0.000255Highly InformativeDirect
Phenotypic Abnormality (PA)Arthritis0.0002811Highly InformativeDirect
Phenotypic Abnormality (PA)Pulmonary infiltrates0.0004823Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of T cell physiology0.0005834Highly InformativeDirect
Phenotypic Abnormality (PA)Increased antibody level in blood0.3498Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal neutrophil cell number0.4899Highly InformativeInherited
Phenotypic Abnormality (PA)Hemolytic anemia1Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype0.00000000299Least InformativeDirect
Mammalian Phenotype (MP)immune system phenotype0.00000002936Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0.000001769Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0.08416Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.463Least InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.0000004294Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.000004765Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal induced morbidity/mortality0.00001712Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cell death0.0009739Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal leukocyte cell number0.006511Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.009963Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.01593Moderately InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.03343Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.0425Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.1102Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.1206Moderately InformativeInherited
Mammalian Phenotype (MP)hearing/vestibular/ear phenotype0.2716Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.3464Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.3848Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.5268Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal myeloid cell morphology0.6795Moderately InformativeInherited
Mammalian Phenotype (MP)decreased hematopoietic cell number0.6925Moderately InformativeInherited
Mammalian Phenotype (MP)autoimmune response0.0000019InformativeDirect
Mammalian Phenotype (MP)abnormal phagocyte morphology0.000006563InformativeDirect
Mammalian Phenotype (MP)abnormal macrophage physiology0.00008156InformativeDirect
Mammalian Phenotype (MP)abnormal circulating cytokine level0.0001337InformativeDirect
Mammalian Phenotype (MP)abnormal liver physiology0.0007544InformativeDirect
Mammalian Phenotype (MP)abnormal intestine physiology0.003086InformativeInherited
Mammalian Phenotype (MP)abnormal spleen morphology0.006425InformativeInherited
Mammalian Phenotype (MP)abnormal lymph node morphology0.01675InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin secretion0.02523InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin level0.06026InformativeInherited
Mammalian Phenotype (MP)abnormal mature B cell morphology0.132InformativeInherited
Mammalian Phenotype (MP)abnormal interferon secretion0.1742InformativeInherited
Mammalian Phenotype (MP)abnormal hearing physiology0.2057InformativeInherited
Mammalian Phenotype (MP)abnormal interferon level0.3841InformativeInherited
Mammalian Phenotype (MP)abnormal respiration0.5593InformativeInherited
Mammalian Phenotype (MP)abnormal Peyer's patch morphology0.8348InformativeInherited
Mammalian Phenotype (MP)abnormal lymph organ size0.8483InformativeInherited
Mammalian Phenotype (MP)decreased T cell number0.9267InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin-1 beta secretion0.00000000000739Highly InformativeDirect
Mammalian Phenotype (MP)abnormal Peyer's patch size0.000000008709Highly InformativeDirect
Mammalian Phenotype (MP)enlarged lymph nodes0.0000002977Highly InformativeDirect
Mammalian Phenotype (MP)decreased interferon-alpha secretion0.000002039Highly InformativeDirect
Mammalian Phenotype (MP)abnormal spleen germinal center morphology0.00002088Highly InformativeDirect
Mammalian Phenotype (MP)abnormal gut flora balance0.00002682Highly InformativeDirect
Mammalian Phenotype (MP)abnormal airway responsiveness0.00006508Highly InformativeDirect
Mammalian Phenotype (MP)decreased apoptosis0.00007253Highly InformativeDirect
Mammalian Phenotype (MP)abnormal B-1 B cell number0.00008067Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating interleukin-18 level0.0002488Highly InformativeDirect
Mammalian Phenotype (MP)abnormal macrophage apoptosis0.0003271Highly InformativeDirect
Mammalian Phenotype (MP)abnormal acute inflammation0.0005895Highly InformativeDirect
Mammalian Phenotype (MP)decreased inflammatory response0.0009529Highly InformativeDirect
Mammalian Phenotype (MP)abnormal interleukin-6 secretion0.05484Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.0000123Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.0008321Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.001182Least InformativeInherited
Worm Phenotype (WP)apoptosis variant0.0002309Moderately InformativeDirect
Worm Phenotype (WP)protein expression variant0.09405Moderately InformativeInherited
Worm Phenotype (WP)pattern protein expression variant0.0002436InformativeDirect
Worm Phenotype (WP)organism pathogen response variant0.0006646InformativeDirect
Worm Phenotype (WP)pathogen susceptibility increased0.000000002588Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.000002043Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorus-containing groups0.0001353Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0Moderately InformativeDirect
Enzyme Commission (EC)Acyltransferases0.06337Moderately InformativeInherited
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect
Enzyme Commission (EC)Cysteine endopeptidases0InformativeDirect
Enzyme Commission (EC)RING-type E3 ubiquitin transferase0.0000007915InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0.000474InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0.0000006799Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis0Moderately InformativeDirect
Biological processImmunity0Moderately InformativeDirect
Biological processDifferentiation0.00002937Moderately InformativeDirect
Biological processHost-virus interaction0.0005469Moderately InformativeDirect
Biological processInflammatory response0InformativeDirect
Biological processInnate immunity0.00000000000004548InformativeDirect
Biological processBiological rhythms0.00000001882InformativeDirect
Cellular componentNucleus0.00000000002675Least InformativeDirect
Cellular componentCytoplasm0.0000000001969Least InformativeDirect
Cellular componentMembrane0.000006762Least InformativeDirect
Cellular componentCell junction0.00001262Moderately InformativeDirect
Cellular componentCell projection0.00001852Moderately InformativeDirect
Cellular componentCytoskeleton0.00005132Moderately InformativeDirect
Cellular componentSynapse0.000000002569InformativeDirect
Cellular componentSarcoplasmic reticulum0.00000002903Highly InformativeDirect
Coding sequence diversityPolymorphism0.00031Moderately InformativeDirect
DiseaseAmyloidosis0.00000006771Highly InformativeDirect
DomainRepeat0Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainANK repeat0InformativeDirect
DomainLeucine-rich repeat0InformativeDirect
DomainImmunoglobulin domain0.0000000005071InformativeDirect
Molecular functionNucleotide-binding0.04473Least InformativeInherited
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationProtease0.000000000004217Moderately InformativeDirect
Post-translational modificationActivator0.000001554Moderately InformativeDirect
Post-translational modificationKinase0.1688Moderately InformativeInherited
Post-translational modificationThiol protease0InformativeDirect
Post-translational modificationCalmodulin-binding0.000000000004774InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0.000000003672InformativeDirect
Post-translational modificationPhosphoprotein0.00000000000001615Least InformativeDirect
Post-translational modificationUbl conjugation0.00000000002927Moderately InformativeDirect
Post-translational modificationZymogen0.00000000008406InformativeDirect
Post-translational modificationHydroxylation0.000446InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR011029 SSF47986 Protein matches
Abstract

The death domain (DD) is a conserved region of about 80 residues found on death receptors, and which is required for death signalling, as well as a variety of non-apoptotic functions [PubMed11828422, PubMed12655292]. Proteins containing this domain include the low affinity neurotrophin receptor p73, Fas, FADD (Fas-associated death domain protein), TNF-1 (tumour necrosis factor receptor-1), Pelle protein kinase, and the Tube adaptor protein [PubMed15226512].

The induction of apoptosis also relies on the presence of a second domain, called the death effector domain. The death effector domain (DED) occurs in proteins that regulate programmed cell death, including both pro- and anti-apoptotic proteins; many of these proteins are also involved in controlling cellular activation and proliferation pathways [PubMed12719729]. Proteins containing this domain include FADD (DED N-terminal, DD C-terminal), PEA-15 (phosphoproteins enriched in astrocytes 15kDa), caspases and FLIP.

The induction of apoptosis results in the activation of caspases, a family of aspartyl-specific cysteine proteases that are the main executioners of apoptosis. For example, the DED of FADD recruits two DED-containing caspases, caspase-8 and caspase-10, to form the death-inducing signal complex, which initiates apoptosis. Proteins containing the caspase recruitment domain (CARD) are involved in the recruitment and activation of caspases during apoptosis [PubMed12101092]. Other CARD proteins participate in NF-kappaB signalling pathways associated with innate or adaptive immune responses. Proteins containing CARD include Raidd, APAF-1 (apoptotic protease activating factor 1), procaspase 9 and iceberg (inhibitor of interleukin-1-beta generation).

The DD shows strong structural similarity to both DED and CARD. They all display a 6-helical closed bundle fold, with greek key topology and an internal psuedo two-fold symmetry. However, despite their overall similarity in topology, each domain forms specialised interactions, typically only with members of its own subfamily, for example DED with DED.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 18 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a DEATH domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 18 hidden Markov models representing the DEATH domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]