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DEATH domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   DEATH domain [ 47985]
Superfamily:   DEATH domain [ 47986] (4)
Families:   DEATH domain, DD [ 81312] (8)
  DEATH effector domain, DED [ 81388] (2)
  Caspase recruitment domain, CARD [ 81313] (5)
  Pyrin domain, PYD [ 101298] (2)


Superfamily statistics
Genomes (141) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 9,108 9,865 25
Proteins 8,310 8,797 25


Functional annotation
General category Processes_IC
Detailed category Cell cycle, Apoptosis

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biological regulation0.029880Least InformativeInherited
Biological Process (BP)regulation of signaling0.00007030.00002295Moderately InformativeDirect
Biological Process (BP)regulation of cell communication0.000071590.00002738Moderately InformativeDirect
Biological Process (BP)regulation of response to stimulus0.00020350.000000000001292Moderately InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.00000003063 Least Informative Direct
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 0.1953 Least Informative Inherited
Biological Process (BP) regulation of signaling 0.00002295 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 0.00002738 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0.000000000001292 Moderately Informative Direct
Biological Process (BP) multi-organism process 0 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 0 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0 Moderately Informative Direct
Biological Process (BP) signaling 0 Moderately Informative Direct
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.000000000000001902 Moderately Informative Direct
Biological Process (BP) cell communication 0.000000000002708 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.00000000001013 Moderately Informative Direct
Biological Process (BP) response to external stimulus 0.000000001907 Moderately Informative Direct
Biological Process (BP) system development 0.0000009773 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.00001126 Moderately Informative Direct
Biological Process (BP) cellular component assembly 0.00002044 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.0002288 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 0.0003483 Moderately Informative Direct
Biological Process (BP) cellular localization 0.2186 Moderately Informative Inherited
Biological Process (BP) single-organism transport 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.02514 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.03879 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.8845 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.00221 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.329 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.9985 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) response to stress 0.03855 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 0.02393 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.7463 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.002215 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.0855 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cell death 0 Informative Direct
Biological Process (BP) regulation of proteolysis 0 Informative Direct
Biological Process (BP) regulation of immune response 0 Informative Direct
Biological Process (BP) positive regulation of immune system process 0 Informative Direct
Biological Process (BP) cell death 0 Informative Direct
Biological Process (BP) regulation of cytokine production 0 Informative Direct
Biological Process (BP) positive regulation of cellular protein metabolic process 0 Informative Direct
Biological Process (BP) regulation of phosphorylation 0.00000000000001409 Informative Direct
Biological Process (BP) response to cytokine 0.0000000000001129 Informative Direct
Biological Process (BP) regulation of defense response 0.000000000004324 Informative Direct
Biological Process (BP) negative regulation of cell death 0.00000000001055 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0.00000000007921 Informative Direct
Biological Process (BP) generation of neurons 0.0000000002027 Informative Direct
Biological Process (BP) cell adhesion 0.0000000007422 Informative Direct
Biological Process (BP) response to bacterium 0.000000006511 Informative Direct
Biological Process (BP) immune response 0.0000002075 Informative Direct
Biological Process (BP) regulation of hydrolase activity 0.000001753 Informative Direct
Biological Process (BP) protein oligomerization 0.000003261 Informative Direct
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 0.000008414 Informative Direct
Biological Process (BP) intracellular signal transduction 0.00006866 Informative Direct
Biological Process (BP) regulation of intracellular signal transduction 0.00007721 Informative Direct
Biological Process (BP) cytoskeleton organization 0.0001518 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.0002027 Informative Direct
Biological Process (BP) regulation of transmembrane transport 0.3044 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.01981 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.002098 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.1925 Informative Inherited
Biological Process (BP) regulation of cellular localization 1 Informative Inherited
Biological Process (BP) regulation of cell differentiation 1 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.8759 Informative Inherited
Biological Process (BP) vesicle-mediated transport 1 Informative Inherited
Biological Process (BP) single-organism membrane organization 0.6182 Informative Inherited
Biological Process (BP) regulation of transferase activity 1 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.3189 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.02504 Informative Inherited
Biological Process (BP) phosphorylation 0.03005 Informative Inherited
Biological Process (BP) regulation of protein localization 0.007699 Informative Inherited
Biological Process (BP) positive regulation of transport 0.6068 Informative Inherited
Biological Process (BP) system process 0.4744 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.004773 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.007049 Informative Inherited
Biological Process (BP) regulation of secretion 0.009495 Informative Inherited
Biological Process (BP) cell development 0.1217 Informative Inherited
Biological Process (BP) growth 0.03656 Informative Inherited
Biological Process (BP) positive regulation of developmental process 1 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.1131 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.0224 Informative Inherited
Biological Process (BP) defense response to other organism 0.008449 Informative Inherited
Biological Process (BP) multi-organism cellular process 0.001056 Informative Inherited
Biological Process (BP) regulation of ion transport 1 Informative Inherited
Biological Process (BP) locomotion 0.0622 Informative Inherited
Biological Process (BP) movement of cell or subcellular component 0.9539 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.7465 Informative Inherited
Biological Process (BP) response to nitrogen compound 0.03872 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.147 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.005363 Informative Inherited
Biological Process (BP) regulation of transcription, DNA-templated 0.02072 Informative Inherited
Biological Process (BP) negative regulation of molecular function 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) secretion 0.0366 Informative Inherited
Biological Process (BP) cellular response to DNA damage stimulus 1 Informative Inherited
Biological Process (BP) regulation of growth 0.3623 Informative Inherited
Biological Process (BP) behavior 0.006914 Informative Inherited
Biological Process (BP) regulation of protein modification process 1 Informative Inherited
Biological Process (BP) single-organism intracellular transport 0.5302 Informative Inherited
Biological Process (BP) protein targeting 0.739 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.4927 Informative Inherited
Biological Process (BP) regulation of locomotion 0.01057 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 0.002701 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.3987 Informative Inherited
Biological Process (BP) embryo development 1 Informative Inherited
Biological Process (BP) epithelium development 0.1234 Informative Inherited
Biological Process (BP) circulatory system development 1 Informative Inherited
Biological Process (BP) microtubule-based process 0.1633 Informative Inherited
Biological Process (BP) regulation of sequence-specific DNA binding transcription factor activity 0 Highly Informative Direct
Biological Process (BP) regulation of cell killing 0 Highly Informative Direct
Biological Process (BP) negative regulation of homeostatic process 0 Highly Informative Direct
Biological Process (BP) regulation of cysteine-type endopeptidase activity 0 Highly Informative Direct
Biological Process (BP) positive regulation of cytokine production 0 Highly Informative Direct
Biological Process (BP) positive regulation of leukocyte proliferation 0.0000000000003199 Highly Informative Direct
Biological Process (BP) positive regulation of proteolysis 0.0000000000004293 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0.0000000009943 Highly Informative Direct
Biological Process (BP) positive regulation of cell adhesion 0.000000004779 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 0.000000007206 Highly Informative Direct
Biological Process (BP) response to molecule of bacterial origin 0.000000007211 Highly Informative Direct
Biological Process (BP) regulation of leukocyte migration 0.00000001532 Highly Informative Direct
Biological Process (BP) leukocyte cell-cell adhesion 0.0000001435 Highly Informative Direct
Biological Process (BP) negative regulation of immune system process 0.0000002286 Highly Informative Direct
Biological Process (BP) regulation of apoptotic signaling pathway 0.0000003797 Highly Informative Direct
Biological Process (BP) cytokine-mediated signaling pathway 0.000001521 Highly Informative Direct
Biological Process (BP) positive regulation of apoptotic process 0.000001608 Highly Informative Direct
Biological Process (BP) neuron development 0.00001063 Highly Informative Direct
Biological Process (BP) apoptotic process 0.00001086 Highly Informative Direct
Biological Process (BP) positive regulation of immune effector process 0.0000159 Highly Informative Direct
Biological Process (BP) positive regulation of protein secretion 0.00001765 Highly Informative Direct
Biological Process (BP) regulation of leukocyte mediated immunity 0.00004069 Highly Informative Direct
Biological Process (BP) microtubule cytoskeleton organization 0.00004149 Highly Informative Direct
Biological Process (BP) developmental growth involved in morphogenesis 0.00006496 Highly Informative Direct
Biological Process (BP) cell killing 0.000102 Highly Informative Direct
Biological Process (BP) vesicle-mediated transport to the plasma membrane 0.0001749 Highly Informative Direct
Biological Process (BP) innate immune response-activating signal transduction 0.0002517 Highly Informative Direct
Biological Process (BP) regulation of leukocyte differentiation 0.0004795 Highly Informative Direct
Biological Process (BP) regulation of protein serine/threonine kinase activity 0.0005019 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 0.0005534 Highly Informative Direct
Biological Process (BP) protein secretion 0.0007046 Highly Informative Direct
Biological Process (BP) activation of protein kinase activity 0.0008472 Highly Informative Direct
Biological Process (BP) cell growth 0.0009116 Highly Informative Direct
Biological Process (BP) regulation of transmembrane transporter activity 0.02252 Highly Informative Inherited
Biological Process (BP) positive regulation of transporter activity 0.1932 Highly Informative Inherited
Biological Process (BP) positive regulation of transmembrane transport 0.2523 Highly Informative Inherited
Biological Process (BP) regulation of cation transmembrane transport 0.2867 Highly Informative Inherited
Biological Process (BP) positive regulation of ion transport 0.7617 Highly Informative Inherited
Biological Process (BP) regulation of protein modification by small protein conjugation or removal 0.01122 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 0.2674 Highly Informative Inherited
Biological Process (BP) detection of stimulus 0.1327 Highly Informative Inherited
Biological Process (BP) endomembrane system organization 0.3376 Highly Informative Inherited
Biological Process (BP) cellular response to abiotic stimulus 0.001403 Highly Informative Inherited
Biological Process (BP) response to mechanical stimulus 0.002646 Highly Informative Inherited
Biological Process (BP) cellular response to external stimulus 1 Highly Informative Inherited
Biological Process (BP) cellular response to organonitrogen compound 0.5605 Highly Informative Inherited
Biological Process (BP) response to endoplasmic reticulum stress 0.03029 Highly Informative Inherited
Biological Process (BP) anatomical structure homeostasis 0.08882 Highly Informative Inherited
Biological Process (BP) modification of morphology or physiology of other organism involved in symbiotic interaction 0.4345 Highly Informative Inherited
Biological Process (BP) positive regulation of nervous system development 0.7481 Highly Informative Inherited
Biological Process (BP) MAPK cascade 1 Highly Informative Inherited
Biological Process (BP) regulation of cytokine secretion 0.001356 Highly Informative Inherited
Biological Process (BP) positive regulation of MAPK cascade 0.7851 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.1622 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular component biogenesis 0.08175 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.1917 Highly Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 0.747 Highly Informative Inherited
Biological Process (BP) positive regulation of lymphocyte activation 0.01847 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 0.001585 Highly Informative Inherited
Biological Process (BP) regulation of lymphocyte proliferation 0.06171 Highly Informative Inherited
Biological Process (BP) response to virus 0.6489 Highly Informative Inherited
Biological Process (BP) chemotaxis 0.3755 Highly Informative Inherited
Biological Process (BP) lymphocyte activation 0.224 Highly Informative Inherited
Biological Process (BP) response to nutrient levels 0.2844 Highly Informative Inherited
Biological Process (BP) hemopoiesis 0.3949 Highly Informative Inherited
Biological Process (BP) single-organism behavior 0.003404 Highly Informative Inherited
Biological Process (BP) sensory perception 0.0572 Highly Informative Inherited
Biological Process (BP) cell projection organization 0.002565 Highly Informative Inherited
Biological Process (BP) cell junction assembly 0.06138 Highly Informative Inherited
Biological Process (BP) establishment of protein localization to membrane 0.03935 Highly Informative Inherited
Biological Process (BP) positive regulation of response to external stimulus 0.9102 Highly Informative Inherited
Biological Process (BP) positive regulation of adaptive immune response based on somatic recombination of immune receptors b 0.003636 Highly Informative Inherited
Biological Process (BP) positive regulation of cell migration 0.008927 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.08076 Highly Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.007026 Highly Informative Inherited
Biological Process (BP) tube morphogenesis 0.1891 Highly Informative Inherited
Biological Process (BP) angiogenesis 0.09123 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) hydrolase activity 0.05842 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) protein binding 0 Moderately Informative Direct
Molecular Function (MF) molecular function regulator 0.001031 Moderately Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 0.7906 Moderately Informative Inherited
Molecular Function (MF) structural molecule activity 0.09885 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.04541 Moderately Informative Inherited
Molecular Function (MF) enzyme activator activity 0.0000007498 Informative Direct
Molecular Function (MF) enzyme binding 0.00002944 Informative Direct
Molecular Function (MF) peptidase regulator activity 0.0003862 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0.0005039 Informative Direct
Molecular Function (MF) peptidase activity, acting on L-amino acid peptides 0.04435 Informative Inherited
Molecular Function (MF) receptor binding 0.6289 Informative Inherited
Molecular Function (MF) molecular transducer activity 0.006422 Informative Inherited
Molecular Function (MF) signal transducer activity 0.001428 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.001954 Informative Inherited
Molecular Function (MF) kinase activity 0.004522 Informative Inherited
Molecular Function (MF) cysteine-type endopeptidase activity 0 Highly Informative Direct
Molecular Function (MF) cytokine receptor binding 0.0000000004684 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase regulator activity involved in apoptotic process 0.00000001874 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0.00003031 Highly Informative Direct
Molecular Function (MF) transmembrane signaling receptor activity 0.0004316 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0.1916 Highly Informative Inherited
Molecular Function (MF) kinase binding 0.3712 Highly Informative Inherited
Molecular Function (MF) transcription factor activity, transcription factor binding 0.02124 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 0.00000000005621 Least Informative Direct
Cellular Component (CC) membrane 0.0000000003343 Least Informative Direct
Cellular Component (CC) protein complex 0.5727 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.03341 Least Informative Inherited
Cellular Component (CC) cytosolic part 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.0000000455 Moderately Informative Direct
Cellular Component (CC) whole membrane 0.007249 Moderately Informative Inherited
Cellular Component (CC) intrinsic component of membrane 1 Moderately Informative Inherited
Cellular Component (CC) cell projection 0.002981 Moderately Informative Inherited
Cellular Component (CC) membrane protein complex 0.8045 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.01964 Moderately Informative Inherited
Cellular Component (CC) membrane region 0.0000000001052 Informative Direct
Cellular Component (CC) neuron projection 0.00000002244 Informative Direct
Cellular Component (CC) synapse 0.0000001391 Informative Direct
Cellular Component (CC) plasma membrane region 0.000001893 Informative Direct
Cellular Component (CC) cell projection part 0.0006747 Informative Direct
Cellular Component (CC) cell junction 0.4708 Informative Inherited
Cellular Component (CC) plasma membrane protein complex 0.00129 Informative Inherited
Cellular Component (CC) cell-cell junction 0.05783 Highly Informative Inherited
Cellular Component (CC) receptor complex 0.0314 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Cysteine endopeptidases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.1957Least InformativeInherited
Disease Ontology (DO)disease by infectious agent0.0000001017Moderately InformativeDirect
Disease Ontology (DO)connective tissue disease0.003126Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.01434Moderately InformativeInherited
Disease Ontology (DO)syndrome0.0643Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.9899Moderately InformativeInherited
Disease Ontology (DO)inflammatory bowel disease0.000004718InformativeDirect
Disease Ontology (DO)arthropathy0.01171InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type IV disease0.03127InformativeInherited
Disease Ontology (DO)viral infectious disease1InformativeInherited
Disease Ontology (DO)irritable bowel syndrome0.000005601Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the immune system0.00007085Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the integument0.006132Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.04771Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.1762Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.2859Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.4173Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the face0.4349Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.7625Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.9174Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.9896Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature1Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.001718Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal inflammatory response0.007977Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.009565Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal respiratory system morphology0.02248Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.09224Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of humoral immunity0.1374Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.3067Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin adnexa0.3512Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the oral cavity0.4696Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.8133Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal genital system morphology0.9412Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle physiology0.9747Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of oral mucosa0.00005263InformativeDirect
Phenotypic Abnormality (PA)Abnormal vascular morphology0.00007759InformativeDirect
Phenotypic Abnormality (PA)CNS infection0.00009096InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the lymphatic system0.001252InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cell physiology0.01323InformativeInherited
Phenotypic Abnormality (PA)Abnormal hair quantity0.06265InformativeInherited
Phenotypic Abnormality (PA)Abnormality of lymphocytes0.1726InformativeInherited
Phenotypic Abnormality (PA)Abnormality of bone marrow cell morphology0.4228InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the testis0.7913InformativeInherited
Phenotypic Abnormality (PA)Lymphadenopathy0.000000002087Highly InformativeDirect
Phenotypic Abnormality (PA)Vasculitis0.00000001114Highly InformativeDirect
Phenotypic Abnormality (PA)Arthralgia0.0000003974Highly InformativeDirect
Phenotypic Abnormality (PA)Splenomegaly0.0000009075Highly InformativeDirect
Phenotypic Abnormality (PA)Inflammatory abnormality of the eye0.0000158Highly InformativeDirect
Phenotypic Abnormality (PA)Recurrent aphthous stomatitis0.0002614Highly InformativeDirect
Phenotypic Abnormality (PA)Myalgia0.000361Highly InformativeDirect
Phenotypic Abnormality (PA)Alopecia0.0004328Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of T cell physiology0.0004446Highly InformativeDirect
Phenotypic Abnormality (PA)Pulmonary infiltrates0.0004996Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of neutrophils0.001937Highly InformativeInherited
Phenotypic Abnormality (PA)Increased antibody level in blood0.3594Highly InformativeInherited
Phenotypic Abnormality (PA)Hemolytic anemia1Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype0.000000006809Least InformativeDirect
Mammalian Phenotype (MP)immune system phenotype0.0000000237Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0.000003068Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0.108Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.4096Least InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to infection0.000000000009047Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal protein level0.0000002351Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.000004271Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal induced morbidity/mortality0.00001719Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cell death0.001031Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.004834Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.0125Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.01553Moderately InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.03688Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.04254Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.1275Moderately InformativeInherited
Mammalian Phenotype (MP)hearing/vestibular/ear phenotype0.2307Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.389Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.4039Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.5676Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal myeloid cell morphology0.6971Moderately InformativeInherited
Mammalian Phenotype (MP)autoimmune response0.000002448InformativeDirect
Mammalian Phenotype (MP)abnormal phagocyte morphology0.000005491InformativeDirect
Mammalian Phenotype (MP)abnormal macrophage physiology0.00007887InformativeDirect
Mammalian Phenotype (MP)abnormal circulating cytokine level0.0003693InformativeDirect
Mammalian Phenotype (MP)abnormal liver physiology0.0008422InformativeDirect
Mammalian Phenotype (MP)abnormal intestine physiology0.00301InformativeInherited
Mammalian Phenotype (MP)abnormal spleen morphology0.005908InformativeInherited
Mammalian Phenotype (MP)abnormal lymph node morphology0.01652InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin secretion0.02429InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin level0.06083InformativeInherited
Mammalian Phenotype (MP)abnormal mature B cell morphology0.1222InformativeInherited
Mammalian Phenotype (MP)abnormal hearing physiology0.1524InformativeInherited
Mammalian Phenotype (MP)abnormal interferon secretion0.1754InformativeInherited
Mammalian Phenotype (MP)abnormal respiratory function0.2716InformativeInherited
Mammalian Phenotype (MP)abnormal interferon level0.3785InformativeInherited
Mammalian Phenotype (MP)abnormal Peyer's patch morphology0.8349InformativeInherited
Mammalian Phenotype (MP)abnormal lymph organ size0.8569InformativeInherited
Mammalian Phenotype (MP)decreased T cell number0.9227InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin-1 beta secretion0.000000000008018Highly InformativeDirect
Mammalian Phenotype (MP)abnormal Peyer's patch size0.00000001025Highly InformativeDirect
Mammalian Phenotype (MP)enlarged lymph nodes0.0000002908Highly InformativeDirect
Mammalian Phenotype (MP)decreased interferon-alpha secretion0.00000225Highly InformativeDirect
Mammalian Phenotype (MP)abnormal spleen germinal center morphology0.00002388Highly InformativeDirect
Mammalian Phenotype (MP)abnormal gut flora balance0.00002665Highly InformativeDirect
Mammalian Phenotype (MP)abnormal airway responsiveness0.00007093Highly InformativeDirect
Mammalian Phenotype (MP)decreased apoptosis0.0000731Highly InformativeDirect
Mammalian Phenotype (MP)abnormal B-1 B cell number0.00009035Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating interleukin-18 level0.0002536Highly InformativeDirect
Mammalian Phenotype (MP)abnormal macrophage apoptosis0.0003273Highly InformativeDirect
Mammalian Phenotype (MP)abnormal acute inflammation0.000587Highly InformativeDirect
Mammalian Phenotype (MP)decreased inflammatory response0.0009548Highly InformativeDirect
Mammalian Phenotype (MP)abnormal interleukin-6 secretion0.05183Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.00006186Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.002122Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.005261Least InformativeInherited
Worm Phenotype (WP)apoptosis variant0.0004564Moderately InformativeDirect
Worm Phenotype (WP)pattern protein expression variant0.0002755InformativeDirect
Worm Phenotype (WP)organism pathogen response variant0.0006325InformativeDirect
Worm Phenotype (WP)pathogen susceptibility increased0.000000004516Highly InformativeDirect
Worm Phenotype (WP)protein subcellular localization variant0.0002108Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)multi-tissue structure0.03352Least InformativeInherited
Zebrafish Anatomy (ZA)compound organ0.3059Least InformativeInherited
Zebrafish Anatomy (ZA)cardiovascular system0.05277Moderately InformativeInherited
Zebrafish Anatomy (ZA)vasculature0.009237InformativeInherited
Zebrafish Anatomy (ZA)blood vasculature0.00009617Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.000002262Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorus-containing groups0.0001822Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0Moderately InformativeDirect
Enzyme Commission (EC)Acyltransferases0.0396Moderately InformativeInherited
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect
Enzyme Commission (EC)Cysteine endopeptidases0InformativeDirect
Enzyme Commission (EC)Aminoacyltransferases0.0000005689InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0.0004711InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0.0000007068Highly InformativeDirect

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)alimentary tract and metabolism0Least InformativeDirect
Drugbank ATC_code (DB)stomatological preparations0Moderately InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis0Moderately InformativeDirect
Biological processImmunity0Moderately InformativeDirect
Biological processDifferentiation0.00002319Moderately InformativeDirect
Biological processInflammatory response0InformativeDirect
Biological processInnate immunity0.0000000000001325InformativeDirect
Biological processBiological rhythms0.00000001743InformativeDirect
Cellular componentNucleus0.00000000003806Least InformativeDirect
Cellular componentCytoplasm0.0000000008469Least InformativeDirect
Cellular componentMembrane0.000008441Least InformativeDirect
Cellular componentCell junction0.00005509Moderately InformativeDirect
Cellular componentCell projection0.0002502Moderately InformativeDirect
Cellular componentCytoskeleton0.0003183Moderately InformativeDirect
Cellular componentSarcoplasmic reticulum0.00000002309Highly InformativeDirect
Coding sequence diversityPolymorphism0.0004596Moderately InformativeDirect
DiseaseAmyloidosis0.0000000772Highly InformativeDirect
DomainRepeat0Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainANK repeat0InformativeDirect
DomainLeucine-rich repeat0InformativeDirect
DomainImmunoglobulin domain0.0000000003994InformativeDirect
Molecular functionNucleotide-binding0.05071Least InformativeInherited
Molecular functionATP-binding0.0004586Moderately InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationProtease0.000000000003028Moderately InformativeDirect
Post-translational modificationActivator0.000005834Moderately InformativeDirect
Post-translational modificationKinase0.1619Moderately InformativeInherited
Post-translational modificationThiol protease0InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0.000000003137InformativeDirect
Post-translational modificationPhosphoprotein0.00000000000001202Least InformativeDirect
Post-translational modificationUbl conjugation0.00000000003754Moderately InformativeDirect
Post-translational modificationZymogen0.00000000006039InformativeDirect
Post-translational modificationHydroxylation0.0004199InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR011029 SSF47986 Protein matches
Abstract

The death domain (DD) is a conserved region of about 80 residues found on death receptors, and which is required for death signalling, as well as a variety of non-apoptotic functions [PubMed11828422, PubMed12655292]. Proteins containing this domain include the low affinity neurotrophin receptor p73, Fas, FADD (Fas-associated death domain protein), TNF-1 (tumour necrosis factor receptor-1), Pelle protein kinase, and the Tube adaptor protein [PubMed15226512].

The induction of apoptosis also relies on the presence of a second domain, called the death effector domain. The death effector domain (DED) occurs in proteins that regulate programmed cell death, including both pro- and anti-apoptotic proteins; many of these proteins are also involved in controlling cellular activation and proliferation pathways [PubMed12719729]. Proteins containing this domain include FADD (DED N-terminal, DD C-terminal), PEA-15 (phosphoproteins enriched in astrocytes 15kDa), caspases and FLIP.

The induction of apoptosis results in the activation of caspases, a family of aspartyl-specific cysteine proteases that are the main executioners of apoptosis. For example, the DED of FADD recruits two DED-containing caspases, caspase-8 and caspase-10, to form the death-inducing signal complex, which initiates apoptosis. Proteins containing the caspase recruitment domain (CARD) are involved in the recruitment and activation of caspases during apoptosis [PubMed12101092]. Other CARD proteins participate in NF-kappaB signalling pathways associated with innate or adaptive immune responses. Proteins containing CARD include Raidd, APAF-1 (apoptotic protease activating factor 1), procaspase 9 and iceberg (inhibitor of interleukin-1-beta generation).

The DD shows strong structural similarity to both DED and CARD. They all display a 6-helical closed bundle fold, with greek key topology and an internal psuedo two-fold symmetry. However, despite their overall similarity in topology, each domain forms specialised interactions, typically only with members of its own subfamily, for example DED with DED.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 18 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a DEATH domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 18 hidden Markov models representing the DEATH domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · Internal database links ]