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post-AAA+ oligomerization domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   post-AAA+ oligomerization domain-like [ 48018]
Superfamily:   post-AAA+ oligomerization domain-like [ 48019] (2)
Families:   DNA polymerase III clamp loader subunits, C-terminal domain [ 48020] (9)
  MgsA/YrvN C-terminal domain-like [ 158600] (3)


Superfamily statistics
Genomes (3,226) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 11,273 58,233 15
Proteins 11,264 58,173 15


Functional annotation
General category Information
Detailed category DNA replication/repair

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) organic cyclic compound metabolic process 0 Least Informative Direct
Biological Process (BP) cellular nitrogen compound metabolic process 0 Least Informative Direct
Biological Process (BP) macromolecule metabolic process 0 Least Informative Direct
Biological Process (BP) primary metabolic process 0 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0 Least Informative Direct
Biological Process (BP) biosynthetic process 0 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0.7871 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.4319 Least Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0.00000000006625 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 0.002905 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.0167 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.2317 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.005283 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.9866 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.5307 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.001392 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.965 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.004174 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.001226 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.7081 Moderately Informative Inherited
Biological Process (BP) animal organ development 0.8289 Moderately Informative Inherited
Biological Process (BP) cellular response to DNA damage stimulus 0 Informative Direct
Biological Process (BP) DNA metabolic process 0 Informative Direct
Biological Process (BP) regulation of transferase activity 0.00000007082 Informative Direct
Biological Process (BP) chromosome organization 0.0000004072 Informative Direct
Biological Process (BP) cell cycle process 0.000000665 Informative Direct
Biological Process (BP) positive regulation of catalytic activity 0.000001679 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.0002807 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0.0008016 Informative Direct
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 0.001419 Informative Inherited
Biological Process (BP) response to radiation 0.01167 Informative Inherited
Biological Process (BP) DNA replication 0 Highly Informative Direct
Biological Process (BP) regulation of DNA metabolic process 0.000000000000003734 Highly Informative Direct
Biological Process (BP) camera-type eye development 0.000005161 Highly Informative Direct
Biological Process (BP) response to UV 0.000007932 Highly Informative Direct
Biological Process (BP) anatomical structure homeostasis 0.0002118 Highly Informative Direct
Biological Process (BP) nuclear chromosome segregation 0.0006045 Highly Informative Direct
Biological Process (BP) cellular response to abiotic stimulus 0.00194 Highly Informative Inherited
Biological Process (BP) nucleic acid phosphodiester bond hydrolysis 0.1262 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0.00002958 Least Informative Direct
Molecular Function (MF) transferase activity 0.6952 Least Informative Inherited
Molecular Function (MF) binding 0.00947 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.000002363 Moderately Informative Direct
Molecular Function (MF) nucleic acid binding 0.002526 Moderately Informative Inherited
Molecular Function (MF) nucleotidyltransferase activity 0 Informative Direct
Molecular Function (MF) ATPase activity 0 Informative Direct
Molecular Function (MF) DNA binding 8.27e-16 Informative Direct
Molecular Function (MF) DNA-directed DNA polymerase activity 0 Highly Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.00003918 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) protein complex 0.1396 Least Informative Inherited
Cellular Component (CC) transferase complex 0 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 0.1722 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.3658 Moderately Informative Inherited
Cellular Component (CC) transferase complex, transferring phosphorus-containing groups 0 Informative Direct
Cellular Component (CC) chromosome 0 Informative Direct
Cellular Component (CC) DNA polymerase complex 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Nucleotidyltransferases0Least InformativeDirect
Enzyme Commission (EC)DNA-directed DNA polymerase0Moderately InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDNA replication0InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationNucleotidyltransferase0.0000000002326Moderately InformativeDirect
Post-translational modificationDNA-binding0.0000001864Moderately InformativeDirect
Post-translational modificationDNA-directed DNA polymerase0Highly InformativeDirect
Post-translational modificationAcetylation0.0000131Least InformativeDirect
Post-translational modificationAutocatalytic cleavage0.000000518InformativeDirect
Post-translational modificationProtein splicing0Highly InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR008921 SSF48019 Protein matches
Abstract

The Escherichia coli DNA polymerase III gamma complex clamp loader assembles the ring-shaped beta sliding clamp onto DNA. The core polymerase is tethered to the template by beta, enabling progressive replication of the genome. The E. coli complex clamp loader contains five different subunits, clamp loading only requires 3 of these - the gamma, delta, delta' complex. Three gamma subunits, and one each of delta and delta', are arranged in a circle. Each subunit adopts the same chain topology, and folds into three domains. However, the relative orientation of these domains is different for each subunit. The carboxy-terminal domains provide the major subunit contacts of the pentamer, although other intersubunit contacts are present. The amino-terminal domains do not form a continuous circle. These domains are arranged in a highly asymmetric fashion, and appear to dangle under the carboxy-terminal pentamer 'umbrella' [PubMed11719243].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 13 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a post-AAA+ oligomerization domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 13 hidden Markov models representing the post-AAA+ oligomerization domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]