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DBL homology domain (DH-domain) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   DBL homology domain (DH-domain) [ 48064]
Superfamily:   DBL homology domain (DH-domain) [ 48065]
Families:   DBL homology domain (DH-domain) [ 48066] (10)


Superfamily statistics
Genomes (401) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 11,355 0 16
Proteins 11,038 0 16


Functional annotation
General category coiled coil
Detailed category The code refers to a 2-stranded_canonical_antiparallel_coiled_coils in the CC+ database. Please click on the link for more information and to visit the CC+ website.

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype0.4443Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.5805Least InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.0159Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.2099Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.4691Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.4718Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.573Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.6319Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.646Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.6741Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.7299Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal B cell proliferation0.005215InformativeInherited
Mammalian Phenotype (MP)abnormal uvea morphology0.06108InformativeInherited
Mammalian Phenotype (MP)abnormal mature B cell morphology0.06748InformativeInherited
Mammalian Phenotype (MP)increased leukocyte cell number0.1579InformativeInherited
Mammalian Phenotype (MP)abnormal intestine morphology0.2377InformativeInherited
Mammalian Phenotype (MP)abnormal anterior eye segment morphology0.2604InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin secretion0.263InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation0.3079InformativeInherited
Mammalian Phenotype (MP)abnormal transitional stage T1 B cell morphology0.000007381Highly InformativeDirect
Mammalian Phenotype (MP)abnormal transitional stage T2 B cell morphology0.00001121Highly InformativeDirect
Mammalian Phenotype (MP)decreased B cell proliferation0.0007743Highly InformativeDirect
Mammalian Phenotype (MP)intestinal ulcer0.0009953Highly InformativeDirect
Mammalian Phenotype (MP)abnormal interleukin-2 secretion0.005879Highly InformativeInherited
Mammalian Phenotype (MP)increased B cell number0.0127Highly InformativeInherited
Mammalian Phenotype (MP)abnormal iris morphology0.02281Highly InformativeInherited
Mammalian Phenotype (MP)decreased immature B cell number0.03881Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cornea morphology0.09407Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.000001173Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.002453Least InformativeInherited
Worm Phenotype (WP)organ system morphology variant0.006556Least InformativeInherited
Worm Phenotype (WP)cell morphology variant0.01723Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.05448Least InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.000000007426Moderately InformativeDirect
Worm Phenotype (WP)metabolic pathway variant0.05336Moderately InformativeInherited
Worm Phenotype (WP)cell component morphology variant0.1808Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.7932Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.8396Moderately InformativeInherited
Worm Phenotype (WP)tail morphology variant0.00000002637InformativeDirect
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.0000815InformativeDirect
Worm Phenotype (WP)organism pathogen response variant0.00008631InformativeDirect
Worm Phenotype (WP)aldicarb response variant0.0002265InformativeDirect
Worm Phenotype (WP)mitochondria morphology variant0.0006361InformativeDirect
Worm Phenotype (WP)protein degradation variant0.0009471InformativeDirect
Worm Phenotype (WP)muscle cell physiology variant0.004835InformativeInherited
Worm Phenotype (WP)bacterially unswollen0Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0.4399Least InformativeInherited
Zebrafish Anatomy (ZA)multi-tissue structure0.9269Least InformativeInherited
Zebrafish Anatomy (ZA)cardiovascular system0.4487Moderately InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.5279Moderately InformativeInherited
Zebrafish Anatomy (ZA)endothelial cell0.003161Highly InformativeInherited
Zebrafish Anatomy (ZA)epithelium0.1335Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation0.000000000000001926Moderately InformativeDirect
Biological processCell cycle0.000009285Moderately InformativeDirect
Biological processImmunity0.002601Moderately InformativeInherited
Biological processNeurogenesis0InformativeDirect
Biological processEndocytosis0.000004569InformativeDirect
Biological processInnate immunity0.0001172InformativeDirect
Biological processSeptation0.0002917Highly InformativeDirect
Cellular componentCytoplasm0.0000000000126Least InformativeDirect
Cellular componentMembrane0.00000707Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentGolgi apparatus0.00006735Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.0007454Moderately InformativeDirect
Cellular componentMicrotubule0.0006808InformativeDirect
Cellular componentSynapse1InformativeInherited
Cellular componentSynaptosome0.0006953Highly InformativeDirect
Coding sequence diversityAlternative splicing0.0000000333Least InformativeDirect
DiseaseProto-oncogene0.00000000001234Moderately InformativeDirect
DomainRepeat0.000000000005943Least InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
DomainZinc-finger0.0000002991Moderately InformativeDirect
DomainSH3 domain0InformativeDirect
DomainSH2 domain0.00000000008013InformativeDirect
DomainImmunoglobulin domain0.00008334InformativeDirect
Molecular functionZinc0.00003151Least InformativeDirect
Molecular functionLipid-binding0.00001867Moderately InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationDevelopmental protein0.0000000001085Moderately InformativeDirect
Post-translational modificationKinase0.05633Moderately InformativeInherited
Post-translational modificationGTPase activation0InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor0InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0.000000001935InformativeDirect
Post-translational modificationCalmodulin-binding0.000001466InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationMyristate0.0002327InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR000219 SSF48065 Protein matches
Abstract

The Rho family GTPases Rho, Rac and CDC42 regulate a diverse array of cellular processes. Like all members of the Ras superfamily, the Rho proteins cycle between active GTP-bound and inactive GDP-bound conformational states. Activation of Rho proteins through release of bound GDP and subsequent binding of GTP, is catalyzed by guanine nucleotide exchange factors (GEFs) in the Dbl family. The proteins encoded by members of the Dbl family share a common domain, presented in this entry, of about 200 residues (designated the Dbl homology or DH domain) that has been shown to encode a GEF activity specific for a number of Rho family members. In addition, all family members possess a second, shared domain designated the pleckstrin homology (PH) domain . Trio and its homolog UNC-73 are unique within the Dbl family insomuch as they encode two distinct DH/PH domain modules. The PH domain is invariably located immediately C-terminal to the DH domain and this invariant topography suggests a functional interdependence between these two structural modules. Biochemical data have established the role of the conserved DH domain in Rho GTPase interaction and activation, and the role of the tandem PH domain in intracellular targeting and/or regulation of DH domain function. The DH domain of Dbl has been shown to mediate oligomerization that is mostly homophilic in nature. In addition to the tandem DH/PH domains Dbl family GEFs contain diverse structural motifs like serine/threonine kinase, RBD, PDZ, RGS, IQ, REM, Cdc25 RasGEF, CH, SH2, SH3, EF, spectrin or Ig.

The DH domain is composed of three structurally conserved regions separated by more variable regions. It does not share significant sequence homology with other subtypes of small G-protein GEF motifs such as the Cdc25 domain and the Sec7 domain, which specifically interact with Ras and ARF family small GTPases, respectively, nor with other Rho protein interactive motifs, indicating that the Dbl family proteins are evolutionarily unique. The DH domain is composed of 11 alpha helices that are folded into a flattened, elongated alpha-helix bundle in which two of the three conserved regions, conserved region 1 (CR1) and conserved region 3 (CR3), are exposed near the centre of one surface. CR1 and CR3, together with a part of alpha-6 and the DH/PH junction site, constitute the Rho GTPase interacting pocket.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 10 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a DBL homology domain (DH-domain) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 10 hidden Markov models representing the DBL homology domain (DH-domain) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]