SUPERFAMILY 1.75 HMM library and genome assignments server


DBL homology domain (DH-domain) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   DBL homology domain (DH-domain) [ 48064]
Superfamily:   DBL homology domain (DH-domain) [ 48065]
Families:   DBL homology domain (DH-domain) [ 48066] (10)


Superfamily statistics
Genomes (360) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 10,078 9,203 16
Proteins 9,805 9,000 16


Functional annotation
General category coiled coil
Detailed category The code refers to a 2-stranded_canonical_antiparallel_coiled_coils in the CC+ database. Please click on the link for more information and to visit the CC+ website.

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process1.896e-051.778e-08Least InformativeDirect
Biological Process (BP)response to stimulus0.00025091.286e-13Least InformativeDirect
Biological Process (BP)regulation of metabolic process5.459e-070.8344Least InformativeInherited
Biological Process (BP)developmental process0.0045780Least InformativeInherited
Biological Process (BP)single-organism cellular process0.024740Least InformativeInherited
Biological Process (BP)regulation of signaling3.37e-090Moderately InformativeDirect
Biological Process (BP)regulation of cell communication3.55e-090Moderately InformativeDirect
Biological Process (BP)regulation of response to stimulus3.906e-082.258e-14Moderately InformativeDirect
Biological Process (BP)anatomical structure morphogenesis6.589e-052.573e-07Moderately InformativeDirect
Biological Process (BP)negative regulation of cellular process7.589e-081Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process7.744e-080.2605Moderately InformativeInherited
Biological Process (BP)regulation of cellular metabolic process1.225e-071Moderately InformativeInherited
Biological Process (BP)signal transduction0.061062.44e-12Moderately InformativeInherited
Biological Process (BP)intracellular signal transduction7.092e-060InformativeDirect
Biological Process (BP)positive regulation of signal transduction0.092831InformativeInherited
Biological Process (BP)regulation of intracellular protein kinase cascade0.16741InformativeInherited
Biological Process (BP)negative regulation of cell death0.021710.385InformativeInherited
Biological Process (BP)regulation of apoptotic process8.218e-060.05845InformativeInherited
Biological Process (BP)positive regulation of protein kinase B signaling cascade1.162e-102.112e-06Highly InformativeDirect
Biological Process (BP)negative regulation of neuron death5.4e-094.523e-05Highly InformativeDirect
Biological Process (BP)small GTPase mediated signal transduction8.17e-080Highly InformativeDirect
Biological Process (BP)regulation of neuron apoptotic process2.979e-080.002775Highly InformativeInherited
Biological Process (BP)negative regulation of apoptotic process1.028e-060.3055Highly InformativeInherited
Molecular Function (MF)enzyme regulator activity2.27e-100Moderately InformativeDirect
Cellular Component (CC)cytoplasmic part0.00030173.222e-06Least InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle0.041321Least InformativeInherited
Cellular Component (CC)cell projection0.00014330Moderately InformativeDirect
Cellular Component (CC)vesicle6.693e-060.05411Moderately InformativeInherited
Cellular Component (CC)cell leading edge3.078e-070InformativeDirect
Cellular Component (CC)lamellipodium3.766e-090Highly InformativeDirect
Cellular Component (CC)endocytic vesicle6.097e-080.0004161Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 1.778e-08 Least Informative Direct
Biological Process (BP) response to stimulus 1.286e-13 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) localization 0.08729 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.8344 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of signaling 0 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 0 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 2.258e-14 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 2.573e-07 Moderately Informative Direct
Biological Process (BP) signal transduction 2.44e-12 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 0.000652 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 7.553e-10 Moderately Informative Direct
Biological Process (BP) nervous system development 2.82e-08 Moderately Informative Direct
Biological Process (BP) response to organic substance 3.131e-05 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 0.9557 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.2605 Moderately Informative Inherited
Biological Process (BP) system process 0.009338 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.05588 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.6011 Moderately Informative Inherited
Biological Process (BP) immune system process 0.006282 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.3321 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 0.0247 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.02103 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.745 Moderately Informative Inherited
Biological Process (BP) reproduction 0.3448 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.004781 Moderately Informative Inherited
Biological Process (BP) intracellular signal transduction 0 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0 Informative Direct
Biological Process (BP) regulation of nervous system development 0 Informative Direct
Biological Process (BP) cytoskeleton organization 0 Informative Direct
Biological Process (BP) actin filament-based process 0 Informative Direct
Biological Process (BP) regulation of cell development 0 Informative Direct
Biological Process (BP) apoptotic process 0 Informative Direct
Biological Process (BP) cell projection organization 0 Informative Direct
Biological Process (BP) locomotion 6.802e-14 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 1.703e-12 Informative Direct
Biological Process (BP) localization of cell 1.562e-10 Informative Direct
Biological Process (BP) synaptic transmission 2.122e-09 Informative Direct
Biological Process (BP) cellular component morphogenesis 5.931e-09 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 7.21e-09 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 1.186e-08 Informative Direct
Biological Process (BP) regulation of hydrolase activity 1.445e-08 Informative Direct
Biological Process (BP) regulation of anatomical structure size 6.125e-08 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 1.474e-07 Informative Direct
Biological Process (BP) pigment metabolic process 1.172e-06 Informative Direct
Biological Process (BP) organ morphogenesis 6.091e-06 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 6.976e-06 Informative Direct
Biological Process (BP) generation of neurons 0.0001508 Informative Direct
Biological Process (BP) negative regulation of developmental process 0.01468 Informative Inherited
Biological Process (BP) growth 0.1608 Informative Inherited
Biological Process (BP) tube development 1 Informative Inherited
Biological Process (BP) epithelium development 0.6221 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 1 Informative Inherited
Biological Process (BP) microtubule-based process 1 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.2464 Informative Inherited
Biological Process (BP) reproductive system development 1 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.1886 Informative Inherited
Biological Process (BP) regulation of growth 0.2818 Informative Inherited
Biological Process (BP) negative regulation of cell death 0.385 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.05845 Informative Inherited
Biological Process (BP) regulation of secretion 0.04566 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) regulation of immune effector process 0.006097 Informative Inherited
Biological Process (BP) cell activation 0.1313 Informative Inherited
Biological Process (BP) cellular component movement 0.01599 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) immune response 0.007927 Informative Inherited
Biological Process (BP) defense response 0.06716 Informative Inherited
Biological Process (BP) immune effector process 0.002683 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.3423 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 1 Informative Inherited
Biological Process (BP) regulation of response to stress 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 1 Informative Inherited
Biological Process (BP) regulation of locomotion 0.01143 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.5498 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.6597 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.08538 Informative Inherited
Biological Process (BP) central nervous system development 0.6631 Informative Inherited
Biological Process (BP) cellular membrane organization 0.9187 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.01103 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.6313 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) sexual reproduction 1 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.8895 Informative Inherited
Biological Process (BP) cell cycle process 1 Informative Inherited
Biological Process (BP) response to external stimulus 0.8869 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.004165 Informative Inherited
Biological Process (BP) positive regulation of protein kinase B signaling cascade 2.112e-06 Highly Informative Direct
Biological Process (BP) negative regulation of neuron death 4.523e-05 Highly Informative Direct
Biological Process (BP) small GTPase mediated signal transduction 0 Highly Informative Direct
Biological Process (BP) apoptotic signaling pathway 0 Highly Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 0 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 0 Highly Informative Direct
Biological Process (BP) regulation of purine nucleotide catabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of cellular component size 9.526e-14 Highly Informative Direct
Biological Process (BP) phagocytosis 4.332e-13 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis 1.269e-11 Highly Informative Direct
Biological Process (BP) post-embryonic organ development 2.619e-10 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 3.214e-09 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 1.063e-08 Highly Informative Direct
Biological Process (BP) cell projection assembly 6.029e-08 Highly Informative Direct
Biological Process (BP) limb morphogenesis 4.174e-07 Highly Informative Direct
Biological Process (BP) regulation of cell projection organization 9.268e-07 Highly Informative Direct
Biological Process (BP) positive regulation of growth 3.045e-06 Highly Informative Direct
Biological Process (BP) gastrulation 3.265e-06 Highly Informative Direct
Biological Process (BP) post-embryonic development 8.833e-06 Highly Informative Direct
Biological Process (BP) chemotaxis 1.44e-05 Highly Informative Direct
Biological Process (BP) T cell activation 5.356e-05 Highly Informative Direct
Biological Process (BP) negative regulation of secretion 9.282e-05 Highly Informative Direct
Biological Process (BP) negative regulation of response to external stimulus 0.0001291 Highly Informative Direct
Biological Process (BP) regulation of neuron differentiation 0.0001425 Highly Informative Direct
Biological Process (BP) regulation of protein complex disassembly 0.8779 Highly Informative Inherited
Biological Process (BP) cell growth 0.007782 Highly Informative Inherited
Biological Process (BP) developmental growth 0.1687 Highly Informative Inherited
Biological Process (BP) organelle assembly 0.1275 Highly Informative Inherited
Biological Process (BP) microtubule cytoskeleton organization 1 Highly Informative Inherited
Biological Process (BP) neuromuscular process 0.2107 Highly Informative Inherited
Biological Process (BP) positive regulation of cell differentiation 0.1434 Highly Informative Inherited
Biological Process (BP) regulation of inflammatory response 0.001394 Highly Informative Inherited
Biological Process (BP) cell fate commitment 1 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.02035 Highly Informative Inherited
Biological Process (BP) regulation of neuron apoptotic process 0.002775 Highly Informative Inherited
Biological Process (BP) negative regulation of apoptotic process 0.3055 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.003082 Highly Informative Inherited
Biological Process (BP) regulation of vesicle-mediated transport 0.1723 Highly Informative Inherited
Biological Process (BP) regulation of Ras protein signal transduction 1 Highly Informative Inherited
Biological Process (BP) innate immune response 0.02072 Highly Informative Inherited
Biological Process (BP) regulation of actin cytoskeleton organization 0.343 Highly Informative Inherited
Biological Process (BP) regulation of protein complex assembly 0.3076 Highly Informative Inherited
Biological Process (BP) lymphocyte differentiation 0.008317 Highly Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 0.4388 Highly Informative Inherited
Biological Process (BP) multi-multicellular organism process 0.06489 Highly Informative Inherited
Biological Process (BP) epithelial tube morphogenesis 1 Highly Informative Inherited
Biological Process (BP) axonogenesis 0.5829 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 0.5427 Highly Informative Inherited
Biological Process (BP) meiosis 0.2118 Highly Informative Inherited
Biological Process (BP) regulation of microtubule polymerization or depolymerization 0.3946 Highly Informative Inherited
Biological Process (BP) negative regulation of cytoskeleton organization 0.7748 Highly Informative Inherited
Biological Process (BP) cell division 0.2032 Highly Informative Inherited
Biological Process (BP) actomyosin structure organization 1 Highly Informative Inherited
Molecular Function (MF) binding 6.266e-12 Least Informative Direct
Molecular Function (MF) enzyme regulator activity 0 Moderately Informative Direct
Molecular Function (MF) protein binding 0 Moderately Informative Direct
Molecular Function (MF) anion binding 1.642e-05 Moderately Informative Direct
Molecular Function (MF) GTPase regulator activity 0 Informative Direct
Molecular Function (MF) lipid binding 3.473e-10 Informative Direct
Molecular Function (MF) enzyme binding 1.823e-09 Informative Direct
Molecular Function (MF) receptor binding 0.2326 Informative Inherited
Molecular Function (MF) enzyme activator activity 1 Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0.0793 Informative Inherited
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0 Highly Informative Direct
Molecular Function (MF) small GTPase regulator activity 8.114e-05 Highly Informative Direct
Molecular Function (MF) tubulin binding 0.004995 Highly Informative Inherited
Molecular Function (MF) phosphatidylinositol binding 0.1959 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 3.222e-06 Least Informative Direct
Cellular Component (CC) membrane 0.0009187 Least Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.01309 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) cytosol 3.428e-08 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.0001314 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.01658 Moderately Informative Inherited
Cellular Component (CC) vesicle 0.05411 Moderately Informative Inherited
Cellular Component (CC) cell leading edge 0 Informative Direct
Cellular Component (CC) neuron part 0 Informative Direct
Cellular Component (CC) cell cortex 9.13e-15 Informative Direct
Cellular Component (CC) cell projection part 5.859e-09 Informative Direct
Cellular Component (CC) contractile fiber part 2.187e-05 Informative Direct
Cellular Component (CC) actin cytoskeleton 0.1011 Informative Inherited
Cellular Component (CC) lamellipodium 0 Highly Informative Direct
Cellular Component (CC) endocytic vesicle 0.0004161 Highly Informative Direct
Cellular Component (CC) cell division site part 1.94e-12 Highly Informative Direct
Cellular Component (CC) cell body 3.498e-05 Highly Informative Direct
Cellular Component (CC) dendrite 3.572e-05 Highly Informative Direct
Cellular Component (CC) ruffle 0.0003786 Highly Informative Direct
Cellular Component (CC) sarcomere 1 Highly Informative Inherited
Cellular Component (CC) extrinsic to plasma membrane 0.002339 Highly Informative Inherited
Cellular Component (CC) internal side of plasma membrane 0.002574 Highly Informative Inherited
Cellular Component (CC) cortical cytoskeleton 0.1768 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details) Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)pharyngeal pumping variant0.0003694Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation4.9e-09Moderately InformativeDirect
Biological processCell cycle4.774e-06Moderately InformativeDirect
Biological processNeurogenesis2.305e-11InformativeDirect
Biological processEndocytosis2.645e-06InformativeDirect
Biological processSeptation0.0007864Highly InformativeDirect
Cellular componentCytoplasm8.709e-10Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentGolgi apparatus2.076e-05Moderately InformativeDirect
Cellular componentEndosome0.0003699Moderately InformativeDirect
Cellular componentMicrotubule0.0003725InformativeDirect
Cellular componentSynapse1InformativeInherited
Cellular componentSynaptosome8.5e-05Highly InformativeDirect
Cellular componentTight junction0.0005856Highly InformativeDirect
Coding sequence diversityAlternative splicing6.88e-07Least InformativeDirect
DiseaseProto-oncogene1.529e-11Least InformativeDirect
DomainRepeat1.753e-10Least InformativeDirect
DomainCoiled coil6.873e-15Moderately InformativeDirect
DomainSH3 domain0InformativeDirect
DomainSH2 domain1.129e-10InformativeDirect
Molecular functionZinc3.217e-05Least InformativeDirect
Molecular functionMetal-binding0.8049Least InformativeInherited
Molecular functionZinc-finger2.323e-16Moderately InformativeDirect
Molecular functionCalmodulin-binding5.005e-07InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationDevelopmental protein3.36e-06Moderately InformativeDirect
Post-translational modificationKinase0.07868Moderately InformativeInherited
Post-translational modificationGTPase activation0InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor0InformativeDirect
Post-translational modificationSerine/threonine-protein kinase5.893e-08InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationMyristate0.0001077InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR000219 SSF48065 Protein matches
Abstract

The Rho family GTPases Rho, Rac and CDC42 regulate a diverse array of cellular processes. Like all members of the Ras superfamily, the Rho proteins cycle between active GTP-bound and inactive GDP-bound conformational states. Activation of Rho proteins through release of bound GDP and subsequent binding of GTP, is catalyzed by guanine nucleotide exchange factors (GEFs) in the Dbl family. The proteins encoded by members of the Dbl family share a common domain, presented in this entry, of about 200 residues (designated the Dbl homology or DH domain) that has been shown to encode a GEF activity specific for a number of Rho family members. In addition, all family members possess a second, shared domain designated the pleckstrin homology (PH) domain . Trio and its homolog UNC-73 are unique within the Dbl family insomuch as they encode two distinct DH/PH domain modules. The PH domain is invariably located immediately C-terminal to the DH domain and this invariant topography suggests a functional interdependence between these two structural modules. Biochemical data have established the role of the conserved DH domain in Rho GTPase interaction and activation, and the role of the tandem PH domain in intracellular targeting and/or regulation of DH domain function. The DH domain of Dbl has been shown to mediate oligomerization that is mostly homophilic in nature. In addition to the tandem DH/PH domains Dbl family GEFs contain diverse structural motifs like serine/threonine kinase, RBD, PDZ, RGS, IQ, REM, Cdc25 RasGEF, CH, SH2, SH3, EF, spectrin or Ig.

The DH domain is composed of three structurally conserved regions separated by more variable regions. It does not share significant sequence homology with other subtypes of small G-protein GEF motifs such as the Cdc25 domain and the Sec7 domain, which specifically interact with Ras and ARF family small GTPases, respectively, nor with other Rho protein interactive motifs, indicating that the Dbl family proteins are evolutionarily unique. The DH domain is composed of 11 alpha helices that are folded into a flattened, elongated alpha-helix bundle in which two of the three conserved regions, conserved region 1 (CR1) and conserved region 3 (CR3), are exposed near the centre of one surface. CR1 and CR3, together with a part of alpha-6 and the DH/PH junction site, constitute the Rho GTPase interacting pocket.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 10 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a DBL homology domain (DH-domain) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 10 hidden Markov models representing the DBL homology domain (DH-domain) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]