SUPERFAMILY 1.75 HMM library and genome assignments server


DBL homology domain (DH-domain) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   DBL homology domain (DH-domain) [ 48064]
Superfamily:   DBL homology domain (DH-domain) [ 48065]
Families:   DBL homology domain (DH-domain) [ 48066] (10)


Superfamily statistics
Genomes (362) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 10,208 9,203 16
Proteins 9,931 9,000 16


Functional annotation
General category coiled coil
Detailed category The code refers to a 2-stranded_canonical_antiparallel_coiled_coils in the CC+ database. Please click on the link for more information and to visit the CC+ website.

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of metabolic process2.582e-070Least InformativeDirect
Biological Process (BP)regulation of cellular process1.163e-051.746e-12Least InformativeDirect
Biological Process (BP)response to stimulus0.00021430Least InformativeDirect
Biological Process (BP)developmental process0.001590Least InformativeInherited
Biological Process (BP)single-organism cellular process0.013310Least InformativeInherited
Biological Process (BP)regulation of signal transduction4.931e-100Moderately InformativeDirect
Biological Process (BP)negative regulation of cellular process0.0043261Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.048860.0001453Moderately InformativeInherited
Biological Process (BP)positive regulation of response to stimulus0.12750.89Moderately InformativeInherited
Biological Process (BP)regulation of programmed cell death2.727e-050.1831Moderately InformativeInherited
Biological Process (BP)regulation of phosphate metabolic process10Moderately InformativeInherited
Biological Process (BP)positive regulation of molecular function1.699e-051Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.63970Moderately InformativeInherited
Biological Process (BP)regulation of catalytic activity0.20980Moderately InformativeInherited
Biological Process (BP)signal transduction0.023044.13e-07Moderately InformativeInherited
Biological Process (BP)regulation of nucleotide catabolic process2.277e-070InformativeDirect
Biological Process (BP)regulation of nucleoside metabolic process2.447e-070InformativeDirect
Biological Process (BP)regulation of purine nucleotide metabolic process6.713e-070InformativeDirect
Biological Process (BP)positive regulation of signal transduction0.21341InformativeInherited
Biological Process (BP)regulation of intracellular protein kinase cascade0.18971InformativeInherited
Biological Process (BP)negative regulation of cell death0.0180.8918InformativeInherited
Biological Process (BP)positive regulation of hydrolase activity3.177e-071InformativeInherited
Biological Process (BP)intracellular signal transduction0.03080InformativeInherited
Biological Process (BP)positive regulation of protein kinase B signaling cascade5.225e-101.985e-06Highly InformativeDirect
Biological Process (BP)regulation of Rho protein signal transduction6.282e-100Highly InformativeDirect
Biological Process (BP)regulation of Ras GTPase activity5.569e-090Highly InformativeDirect
Biological Process (BP)negative regulation of neuron death1.468e-087.24e-05Highly InformativeDirect
Biological Process (BP)small GTPase mediated signal transduction1.853e-070Highly InformativeDirect
Biological Process (BP)regulation of neuron apoptotic process7.794e-080.7402Highly InformativeInherited
Biological Process (BP)positive regulation of GTPase activity4.074e-091Highly InformativeInherited
Molecular Function (MF)enzyme regulator activity1.644e-090Moderately InformativeDirect
Cellular Component (CC)cytoplasmic part0.0020712.468e-06Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.072181Least InformativeInherited
Cellular Component (CC)vesicle8.499e-054.957e-05Moderately InformativeDirect
Cellular Component (CC)cell projection0.00020160Moderately InformativeDirect
Cellular Component (CC)cell leading edge4.408e-070InformativeDirect
Cellular Component (CC)endocytic vesicle1.911e-073.361e-06Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of metabolic process 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 1.746e-12 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) localization 0.002856 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of signal transduction 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0 Moderately Informative Direct
Biological Process (BP) signal transduction 4.13e-07 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 0.0001845 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 3.461e-07 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.0001453 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 1.793e-08 Moderately Informative Direct
Biological Process (BP) nervous system development 1.477e-07 Moderately Informative Direct
Biological Process (BP) immune system process 0.0002277 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.89 Moderately Informative Inherited
Biological Process (BP) system process 0.05853 Moderately Informative Inherited
Biological Process (BP) organ development 0.9851 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.8361 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.2148 Moderately Informative Inherited
Biological Process (BP) regulation of programmed cell death 0.1831 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.2227 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.007398 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.08568 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.3323 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.002089 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.9464 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.9004 Moderately Informative Inherited
Biological Process (BP) reproduction 0.1249 Moderately Informative Inherited
Biological Process (BP) regulation of nucleotide catabolic process 0 Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 0 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 1.651e-07 Informative Direct
Biological Process (BP) intracellular signal transduction 0 Informative Direct
Biological Process (BP) regulation of nervous system development 0 Informative Direct
Biological Process (BP) cytoskeleton organization 0 Informative Direct
Biological Process (BP) actin filament-based process 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) regulation of cell development 0 Informative Direct
Biological Process (BP) localization of cell 0 Informative Direct
Biological Process (BP) cell projection organization 0 Informative Direct
Biological Process (BP) cellular component movement 5.506e-13 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 1.439e-11 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 4.351e-10 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 5.558e-09 Informative Direct
Biological Process (BP) regulation of anatomical structure size 7.747e-09 Informative Direct
Biological Process (BP) cellular component morphogenesis 3.295e-07 Informative Direct
Biological Process (BP) pigment metabolic process 5.237e-06 Informative Direct
Biological Process (BP) cell death 8.879e-06 Informative Direct
Biological Process (BP) organ morphogenesis 1.579e-05 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0.0001969 Informative Direct
Biological Process (BP) generation of neurons 0.0002264 Informative Direct
Biological Process (BP) negative regulation of developmental process 0.1262 Informative Inherited
Biological Process (BP) growth 0.05124 Informative Inherited
Biological Process (BP) response to organonitrogen compound 1 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 1 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 1 Informative Inherited
Biological Process (BP) epithelium development 0.5417 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.01699 Informative Inherited
Biological Process (BP) organelle assembly 0.1738 Informative Inherited
Biological Process (BP) microtubule-based process 1 Informative Inherited
Biological Process (BP) protein complex assembly 1 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.2385 Informative Inherited
Biological Process (BP) regulation of defense response 0.3469 Informative Inherited
Biological Process (BP) reproductive structure development 0.9796 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.155 Informative Inherited
Biological Process (BP) positive regulation of gene expression 0.006447 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.01027 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.01389 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.0412 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 1 Informative Inherited
Biological Process (BP) regulation of growth 0.4159 Informative Inherited
Biological Process (BP) negative regulation of cell death 0.8918 Informative Inherited
Biological Process (BP) regulation of secretion 0.06125 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) regulation of immune effector process 0.01147 Informative Inherited
Biological Process (BP) sensory organ development 1 Informative Inherited
Biological Process (BP) embryonic organ development 1 Informative Inherited
Biological Process (BP) immune response 0.04002 Informative Inherited
Biological Process (BP) defense response 0.1087 Informative Inherited
Biological Process (BP) immune effector process 0.03492 Informative Inherited
Biological Process (BP) secondary metabolic process 0.001213 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 1 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) regulation of cytokine production 1 Informative Inherited
Biological Process (BP) response to bacterium 0.295 Informative Inherited
Biological Process (BP) response to lipid 1 Informative Inherited
Biological Process (BP) regulation of cell cycle 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 1 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.8604 Informative Inherited
Biological Process (BP) cell activation 0.01238 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.229 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.06408 Informative Inherited
Biological Process (BP) central nervous system development 0.7975 Informative Inherited
Biological Process (BP) membrane organization 1 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.004352 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.5102 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) sexual reproduction 1 Informative Inherited
Biological Process (BP) cell-cell signaling 0.1522 Informative Inherited
Biological Process (BP) transmission of nerve impulse 0.001556 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.8446 Informative Inherited
Biological Process (BP) cell cycle process 1 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.001145 Informative Inherited
Biological Process (BP) positive regulation of protein kinase B signaling cascade 1.985e-06 Highly Informative Direct
Biological Process (BP) regulation of Rho protein signal transduction 0 Highly Informative Direct
Biological Process (BP) regulation of Ras GTPase activity 0 Highly Informative Direct
Biological Process (BP) negative regulation of neuron death 7.24e-05 Highly Informative Direct
Biological Process (BP) small GTPase mediated signal transduction 0 Highly Informative Direct
Biological Process (BP) positive regulation of programmed cell death 0 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 0 Highly Informative Direct
Biological Process (BP) chemotaxis 2.112e-14 Highly Informative Direct
Biological Process (BP) phagocytosis 5.721e-14 Highly Informative Direct
Biological Process (BP) T cell differentiation 4.081e-11 Highly Informative Direct
Biological Process (BP) post-embryonic organ development 4.306e-10 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 2.29e-09 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 3.248e-09 Highly Informative Direct
Biological Process (BP) leukocyte migration 1.298e-08 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 1.927e-08 Highly Informative Direct
Biological Process (BP) cell projection assembly 1.372e-07 Highly Informative Direct
Biological Process (BP) limb morphogenesis 1.312e-06 Highly Informative Direct
Biological Process (BP) regulation of neuron projection development 2.845e-06 Highly Informative Direct
Biological Process (BP) post-embryonic development 1.27e-05 Highly Informative Direct
Biological Process (BP) negative regulation of secretion 8.379e-05 Highly Informative Direct
Biological Process (BP) negative regulation of response to external stimulus 0.0001091 Highly Informative Direct
Biological Process (BP) regulation of protein depolymerization 0.0003051 Highly Informative Direct
Biological Process (BP) positive regulation of growth 0.0005188 Highly Informative Direct
Biological Process (BP) response to lipopolysaccharide 0.0008512 Highly Informative Direct
Biological Process (BP) negative regulation of protein complex disassembly 0.0008806 Highly Informative Direct
Biological Process (BP) cell growth 0.013 Highly Informative Inherited
Biological Process (BP) developmental growth 0.2512 Highly Informative Inherited
Biological Process (BP) renal system development 1 Highly Informative Inherited
Biological Process (BP) cellular response to peptide 0.00657 Highly Informative Inherited
Biological Process (BP) actin filament-based movement 0.6396 Highly Informative Inherited
Biological Process (BP) regulation of actin cytoskeleton organization 0.2263 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.1491 Highly Informative Inherited
Biological Process (BP) microtubule cytoskeleton organization 1 Highly Informative Inherited
Biological Process (BP) neuromuscular process 0.1232 Highly Informative Inherited
Biological Process (BP) positive regulation of cell differentiation 0.08864 Highly Informative Inherited
Biological Process (BP) regulation of inflammatory response 0.001602 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.05142 Highly Informative Inherited
Biological Process (BP) cell fate commitment 1 Highly Informative Inherited
Biological Process (BP) positive regulation of transcription, DNA-dependent 0.002584 Highly Informative Inherited
Biological Process (BP) regulation of cell size 0.008085 Highly Informative Inherited
Biological Process (BP) regulation of cell adhesion 0.005183 Highly Informative Inherited
Biological Process (BP) regulation of neuron apoptotic process 0.7402 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.008706 Highly Informative Inherited
Biological Process (BP) regulation of vesicle-mediated transport 0.2457 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 1 Highly Informative Inherited
Biological Process (BP) innate immune response 0.03582 Highly Informative Inherited
Biological Process (BP) positive regulation of GTPase activity 1 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.01121 Highly Informative Inherited
Biological Process (BP) maintenance of location 0.06255 Highly Informative Inherited
Biological Process (BP) regulation of protein complex assembly 0.3636 Highly Informative Inherited
Biological Process (BP) development of primary male sexual characteristics 0.01434 Highly Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 0.4676 Highly Informative Inherited
Biological Process (BP) epithelial tube morphogenesis 1 Highly Informative Inherited
Biological Process (BP) neuron projection development 0.4459 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.5959 Highly Informative Inherited
Biological Process (BP) cell part morphogenesis 1 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 0.6184 Highly Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 1 Highly Informative Inherited
Biological Process (BP) meiosis 0.1696 Highly Informative Inherited
Biological Process (BP) regulation of microtubule polymerization or depolymerization 0.3677 Highly Informative Inherited
Biological Process (BP) negative regulation of cytoskeleton organization 0.8942 Highly Informative Inherited
Biological Process (BP) cell division 0.005012 Highly Informative Inherited
Biological Process (BP) actomyosin structure organization 0.9579 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) enzyme regulator activity 0 Moderately Informative Direct
Molecular Function (MF) anion binding 4.572e-07 Moderately Informative Direct
Molecular Function (MF) GTPase regulator activity 0 Informative Direct
Molecular Function (MF) lipid binding 3.673e-13 Informative Direct
Molecular Function (MF) enzyme binding 3.79e-10 Informative Direct
Molecular Function (MF) receptor binding 0.1725 Informative Inherited
Molecular Function (MF) enzyme activator activity 1 Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0.1089 Informative Inherited
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0 Highly Informative Direct
Molecular Function (MF) small GTPase regulator activity 7.629e-05 Highly Informative Direct
Molecular Function (MF) Ras GTPase binding 1 Highly Informative Inherited
Molecular Function (MF) tubulin binding 0.004736 Highly Informative Inherited
Molecular Function (MF) phosphatidylinositol binding 0.04659 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 2.468e-06 Least Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.0003972 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) membrane 0.0135 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) vesicle 4.957e-05 Moderately Informative Direct
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) cytosol 2.242e-07 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.0007449 Moderately Informative Direct
Cellular Component (CC) plasma membrane part 0.4068 Moderately Informative Inherited
Cellular Component (CC) cell leading edge 0 Informative Direct
Cellular Component (CC) cell cortex 0 Informative Direct
Cellular Component (CC) contractile fiber part 6.069e-05 Informative Direct
Cellular Component (CC) synapse part 0.00135 Informative Inherited
Cellular Component (CC) neuron projection 0.9551 Informative Inherited
Cellular Component (CC) actin cytoskeleton 0.6835 Informative Inherited
Cellular Component (CC) endocytic vesicle 3.361e-06 Highly Informative Direct
Cellular Component (CC) internal side of plasma membrane 1.284e-14 Highly Informative Direct
Cellular Component (CC) extrinsic to plasma membrane 1.418e-14 Highly Informative Direct
Cellular Component (CC) cell division site part 2.229e-14 Highly Informative Direct
Cellular Component (CC) contractile ring 9.73e-11 Highly Informative Direct
Cellular Component (CC) cell body 7.613e-05 Highly Informative Direct
Cellular Component (CC) growth cone 0.0003156 Highly Informative Direct
Cellular Component (CC) lateral plasma membrane 0.0006484 Highly Informative Direct
Cellular Component (CC) dendrite 0.006117 Highly Informative Inherited
Cellular Component (CC) sarcomere 1 Highly Informative Inherited
Cellular Component (CC) cortical cytoskeleton 0.2349 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details) Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype0.3202Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.443Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.4771Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.5937Least InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.06571Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.09713Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.1001Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukopoiesis0.4633Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.6397Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.7043Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal uvea morphology0.04114InformativeInherited
Mammalian Phenotype (MP)decreased hematopoietic cell number0.1112InformativeInherited
Mammalian Phenotype (MP)abnormal anterior eye segment morphology0.1485InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation0.3053InformativeInherited
Mammalian Phenotype (MP)increased leukocyte cell number0.3804InformativeInherited
Mammalian Phenotype (MP)abnormal lymphocyte cell number0.4977InformativeInherited
Mammalian Phenotype (MP)abnormal vascular endothelial cell development0.003519Highly InformativeInherited
Mammalian Phenotype (MP)abnormal iris morphology0.01323Highly InformativeInherited
Mammalian Phenotype (MP)decreased B cell number0.0696Highly InformativeInherited
Mammalian Phenotype (MP)abnormal immature B cell morphology0.3072Highly InformativeInherited
Mammalian Phenotype (MP)increased lymphocyte cell number0.8775Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)pharyngeal pumping variant0.0003694Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation6.995e-09Moderately InformativeDirect
Biological processCell cycle5.126e-06Moderately InformativeDirect
Biological processNeurogenesis3.329e-11InformativeDirect
Biological processEndocytosis3.071e-06InformativeDirect
Biological processInnate immunity2.495e-05InformativeDirect
Biological processSeptation0.0007463Highly InformativeDirect
Cellular componentCytoplasm1.015e-09Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentGolgi apparatus2.47e-05Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.0001394Moderately InformativeDirect
Cellular componentEndosome0.0006089Moderately InformativeDirect
Cellular componentMicrotubule0.0003407InformativeDirect
Cellular componentSynapse1InformativeInherited
Cellular componentSynaptosome0.0001051Highly InformativeDirect
Coding sequence diversityAlternative splicing1.315e-07Least InformativeDirect
DiseaseProto-oncogene4.905e-12Moderately InformativeDirect
DomainRepeat1.643e-11Least InformativeDirect
DomainCoiled coil3.106e-16Moderately InformativeDirect
DomainZinc-finger1.326e-06Moderately InformativeDirect
DomainSH3 domain0InformativeDirect
DomainSH2 domain6.105e-11InformativeDirect
Molecular functionZinc3.512e-05Least InformativeDirect
Molecular functionCalmodulin-binding5.674e-07InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationDevelopmental protein3.024e-06Moderately InformativeDirect
Post-translational modificationKinase0.08112Moderately InformativeInherited
Post-translational modificationGTPase activation0InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor0InformativeDirect
Post-translational modificationSerine/threonine-protein kinase5.839e-08InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationMyristate0.0001096InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR000219 SSF48065 Protein matches
Abstract

The Rho family GTPases Rho, Rac and CDC42 regulate a diverse array of cellular processes. Like all members of the Ras superfamily, the Rho proteins cycle between active GTP-bound and inactive GDP-bound conformational states. Activation of Rho proteins through release of bound GDP and subsequent binding of GTP, is catalyzed by guanine nucleotide exchange factors (GEFs) in the Dbl family. The proteins encoded by members of the Dbl family share a common domain, presented in this entry, of about 200 residues (designated the Dbl homology or DH domain) that has been shown to encode a GEF activity specific for a number of Rho family members. In addition, all family members possess a second, shared domain designated the pleckstrin homology (PH) domain . Trio and its homolog UNC-73 are unique within the Dbl family insomuch as they encode two distinct DH/PH domain modules. The PH domain is invariably located immediately C-terminal to the DH domain and this invariant topography suggests a functional interdependence between these two structural modules. Biochemical data have established the role of the conserved DH domain in Rho GTPase interaction and activation, and the role of the tandem PH domain in intracellular targeting and/or regulation of DH domain function. The DH domain of Dbl has been shown to mediate oligomerization that is mostly homophilic in nature. In addition to the tandem DH/PH domains Dbl family GEFs contain diverse structural motifs like serine/threonine kinase, RBD, PDZ, RGS, IQ, REM, Cdc25 RasGEF, CH, SH2, SH3, EF, spectrin or Ig.

The DH domain is composed of three structurally conserved regions separated by more variable regions. It does not share significant sequence homology with other subtypes of small G-protein GEF motifs such as the Cdc25 domain and the Sec7 domain, which specifically interact with Ras and ARF family small GTPases, respectively, nor with other Rho protein interactive motifs, indicating that the Dbl family proteins are evolutionarily unique. The DH domain is composed of 11 alpha helices that are folded into a flattened, elongated alpha-helix bundle in which two of the three conserved regions, conserved region 1 (CR1) and conserved region 3 (CR3), are exposed near the centre of one surface. CR1 and CR3, together with a part of alpha-6 and the DH/PH junction site, constitute the Rho GTPase interacting pocket.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 10 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a DBL homology domain (DH-domain) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 10 hidden Markov models representing the DBL homology domain (DH-domain) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]