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DBL homology domain (DH-domain) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   DBL homology domain (DH-domain) [ 48064]
Superfamily:   DBL homology domain (DH-domain) [ 48065]
Families:   DBL homology domain (DH-domain) [ 48066] (10)


Superfamily statistics
Genomes (394) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 11,022 12,001 16
Proteins 10,714 11,712 16


Functional annotation
General category coiled coil
Detailed category The code refers to a 2-stranded_canonical_antiparallel_coiled_coils in the CC+ database. Please click on the link for more information and to visit the CC+ website.

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.000000000000003692 Least Informative Direct
Biological Process (BP) response to stimulus 0.000006054 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cell communication 0 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 0 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0 Moderately Informative Direct
Biological Process (BP) regulation of signaling 0 Moderately Informative Direct
Biological Process (BP) signaling 0.000000000000003692 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.00000000002816 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.00000008797 Moderately Informative Direct
Biological Process (BP) cellular developmental process 0.0000003631 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.000003639 Moderately Informative Direct
Biological Process (BP) immune system process 0.000181 Moderately Informative Direct
Biological Process (BP) cell communication 0.0003111 Moderately Informative Direct
Biological Process (BP) system development 0.0004432 Moderately Informative Direct
Biological Process (BP) cellular component assembly 0.5258 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.0417 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.07024 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.02928 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.4804 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.5619 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.8573 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) response to stress 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.7631 Moderately Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0 Informative Direct
Biological Process (BP) regulation of nervous system development 0 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0 Informative Direct
Biological Process (BP) actin filament-based process 0 Informative Direct
Biological Process (BP) regulation of apoptotic process 0 Informative Direct
Biological Process (BP) locomotion 0.0000000000001036 Informative Direct
Biological Process (BP) cytoskeleton organization 0.00000000000634 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0.0000000002729 Informative Direct
Biological Process (BP) post-embryonic development 0.0000000003875 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0.0000000004667 Informative Direct
Biological Process (BP) pigment metabolic process 0.000000000522 Informative Direct
Biological Process (BP) positive regulation of signal transduction 0.000000001074 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.000000001923 Informative Direct
Biological Process (BP) regulation of hydrolase activity 0.0000001765 Informative Direct
Biological Process (BP) secondary metabolic process 0.0000004599 Informative Direct
Biological Process (BP) animal organ morphogenesis 0.0000005191 Informative Direct
Biological Process (BP) epithelium development 0.0000005968 Informative Direct
Biological Process (BP) cell adhesion 0.000001188 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.000002081 Informative Direct
Biological Process (BP) intracellular signal transduction 0.000006391 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.00001655 Informative Direct
Biological Process (BP) positive regulation of cell death 0.00001768 Informative Direct
Biological Process (BP) generation of neurons 0.0001822 Informative Direct
Biological Process (BP) mitotic cell cycle 0.1699 Informative Inherited
Biological Process (BP) growth 0.07199 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.0334 Informative Inherited
Biological Process (BP) regulation of cell differentiation 0.00598 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.008585 Informative Inherited
Biological Process (BP) organelle assembly 0.2401 Informative Inherited
Biological Process (BP) reproductive system development 1 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 0.5544 Informative Inherited
Biological Process (BP) regulation of growth 0.01633 Informative Inherited
Biological Process (BP) positive regulation of developmental process 1 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.328 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.004178 Informative Inherited
Biological Process (BP) immune response 0.1188 Informative Inherited
Biological Process (BP) regulation of phosphorylation 0.2264 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 0.01014 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) regulation of cytokine production 1 Informative Inherited
Biological Process (BP) response to nitrogen compound 0.4143 Informative Inherited
Biological Process (BP) regulation of cell cycle 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.01061 Informative Inherited
Biological Process (BP) regulation of protein modification process 0.04059 Informative Inherited
Biological Process (BP) embryo development 0.8433 Informative Inherited
Biological Process (BP) system process 1 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.568 Informative Inherited
Biological Process (BP) behavior 0.001778 Informative Inherited
Biological Process (BP) central nervous system development 0.9922 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.6783 Informative Inherited
Biological Process (BP) cell development 0.005236 Informative Inherited
Biological Process (BP) multi-organism reproductive process 0.01771 Informative Inherited
Biological Process (BP) organelle fission 1 Informative Inherited
Biological Process (BP) cell cycle process 0.125 Informative Inherited
Biological Process (BP) single organism reproductive process 0.7027 Informative Inherited
Biological Process (BP) microtubule-based process 0.197 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.00191 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.09285 Informative Inherited
Biological Process (BP) positive regulation of cellular component biogenesis 0 Highly Informative Direct
Biological Process (BP) regulation of cell shape 0 Highly Informative Direct
Biological Process (BP) small GTPase mediated signal transduction 0 Highly Informative Direct
Biological Process (BP) metamorphosis 0 Highly Informative Direct
Biological Process (BP) cell projection organization 0 Highly Informative Direct
Biological Process (BP) cell migration 0 Highly Informative Direct
Biological Process (BP) instar larval or pupal morphogenesis 0 Highly Informative Direct
Biological Process (BP) regulation of actin filament polymerization 0 Highly Informative Direct
Biological Process (BP) appendage development 0.000000000000001902 Highly Informative Direct
Biological Process (BP) positive regulation of apoptotic process 0.000000000000007239 Highly Informative Direct
Biological Process (BP) positive regulation of GTPase activity 0.000000000007443 Highly Informative Direct
Biological Process (BP) tube morphogenesis 0.000000000008234 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 0.00000000002265 Highly Informative Direct
Biological Process (BP) chemotaxis 0.000000001359 Highly Informative Direct
Biological Process (BP) morphogenesis of an epithelium 0.00000008894 Highly Informative Direct
Biological Process (BP) neuron development 0.000007153 Highly Informative Direct
Biological Process (BP) innate immune response 0.000009292 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.00001253 Highly Informative Direct
Biological Process (BP) gastrulation 0.00001945 Highly Informative Direct
Biological Process (BP) cell division 0.0002565 Highly Informative Direct
Biological Process (BP) actin filament organization 0.000644 Highly Informative Direct
Biological Process (BP) cell growth 0.0009308 Highly Informative Direct
Biological Process (BP) regulation of circadian rhythm 0.278 Highly Informative Inherited
Biological Process (BP) sex differentiation 0.003773 Highly Informative Inherited
Biological Process (BP) developmental growth involved in morphogenesis 0.04274 Highly Informative Inherited
Biological Process (BP) cellular response to organonitrogen compound 0.0133 Highly Informative Inherited
Biological Process (BP) muscle structure development 0.5153 Highly Informative Inherited
Biological Process (BP) cell proliferation 0.6213 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.01232 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.01692 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.02975 Highly Informative Inherited
Biological Process (BP) positive regulation of nervous system development 0.0108 Highly Informative Inherited
Biological Process (BP) regulation of cell size 0.07763 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.02001 Highly Informative Inherited
Biological Process (BP) positive regulation of cell development 0.6262 Highly Informative Inherited
Biological Process (BP) regulation of cell growth 1 Highly Informative Inherited
Biological Process (BP) endocytosis 0.05112 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 1 Highly Informative Inherited
Biological Process (BP) positive regulation of MAPK cascade 1 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.6113 Highly Informative Inherited
Biological Process (BP) maintenance of location in cell 0.001705 Highly Informative Inherited
Biological Process (BP) regulation of cell division 0.02274 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.001247 Highly Informative Inherited
Biological Process (BP) negative regulation of cytoskeleton organization 1 Highly Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.452 Highly Informative Inherited
Biological Process (BP) hemostasis 0.02165 Highly Informative Inherited
Biological Process (BP) wound healing 0.07207 Highly Informative Inherited
Biological Process (BP) coagulation 0.1184 Highly Informative Inherited
Biological Process (BP) sensory perception 0.405 Highly Informative Inherited
Biological Process (BP) brain development 0.2868 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.7073 Highly Informative Inherited
Biological Process (BP) meiotic cell cycle process 0.1145 Highly Informative Inherited
Biological Process (BP) microtubule cytoskeleton organization 1 Highly Informative Inherited
Biological Process (BP) endomembrane system organization 0.06292 Highly Informative Inherited
Biological Process (BP) regulation of protein complex disassembly 0.657 Highly Informative Inherited
Biological Process (BP) microtubule-based movement 0.8869 Highly Informative Inherited
Biological Process (BP) actomyosin structure organization 0.8696 Highly Informative Inherited
Molecular Function (MF) binding 0.0004855 Least Informative Direct
Molecular Function (MF) protein binding 0 Moderately Informative Direct
Molecular Function (MF) molecular function regulator 0 Moderately Informative Direct
Molecular Function (MF) structural molecule activity 0.0003757 Moderately Informative Direct
Molecular Function (MF) anion binding 0.2043 Moderately Informative Inherited
Molecular Function (MF) enzyme binding 0 Informative Direct
Molecular Function (MF) enzyme activator activity 0.0000000000154 Informative Direct
Molecular Function (MF) phospholipid binding 0.000001879 Informative Direct
Molecular Function (MF) receptor binding 0.4858 Informative Inherited
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0 Highly Informative Direct
Molecular Function (MF) small GTPase binding 0 Highly Informative Direct
Molecular Function (MF) GTPase regulator activity 0.0000000002649 Highly Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0.000003032 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.03961 Least Informative Inherited
Cellular Component (CC) membrane 0.9032 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.0001231 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.1164 Moderately Informative Inherited
Cellular Component (CC) site of polarized growth 0 Informative Direct
Cellular Component (CC) cytoplasmic region 0 Informative Direct
Cellular Component (CC) extrinsic component of membrane 0.00000000000000601 Informative Direct
Cellular Component (CC) side of membrane 0.000000007435 Informative Direct
Cellular Component (CC) cell projection part 0.00000001617 Informative Direct
Cellular Component (CC) synapse 0.000001345 Informative Direct
Cellular Component (CC) plasma membrane region 0.0004516 Informative Direct
Cellular Component (CC) cell surface 0.4815 Informative Inherited
Cellular Component (CC) apical part of cell 0.001873 Informative Inherited
Cellular Component (CC) actin cytoskeleton 0.001576 Informative Inherited
Cellular Component (CC) neuron projection 0.01019 Informative Inherited
Cellular Component (CC) extrinsic component of cytoplasmic side of plasma membrane 0 Highly Informative Direct
Cellular Component (CC) cell division site 0.00000000000002858 Highly Informative Direct
Cellular Component (CC) contractile fiber part 0.00000001339 Highly Informative Direct
Cellular Component (CC) lamellipodium 0.0000002095 Highly Informative Direct
Cellular Component (CC) ruffle 0.0000004099 Highly Informative Direct
Cellular Component (CC) growth cone 0.00001444 Highly Informative Direct
Cellular Component (CC) myofibril 0.8591 Highly Informative Inherited
Cellular Component (CC) cortical cytoskeleton 0.002199 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the face0.6474Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.7548Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.779Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin adnexa0.2162Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin morphology0.8442Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the scalp hair0.04065InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the forehead0.1404InformativeInherited
Phenotypic Abnormality (PA)High anterior hairline0.0001327Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormally lax or hyperextensible skin0.004974Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype0.3665Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.5295Least InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.01508Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.2068Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.4833Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.5229Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.5725Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.622Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.6756Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.6862Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.812Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal B cell proliferation0.00523InformativeInherited
Mammalian Phenotype (MP)abnormal uvea morphology0.0566InformativeInherited
Mammalian Phenotype (MP)abnormal mature B cell morphology0.06236InformativeInherited
Mammalian Phenotype (MP)abnormal intestine morphology0.2355InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin secretion0.2611InformativeInherited
Mammalian Phenotype (MP)increased hematopoietic cell number0.2628InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation0.3042InformativeInherited
Mammalian Phenotype (MP)abnormal anterior eye segment morphology0.3935InformativeInherited
Mammalian Phenotype (MP)abnormal transitional stage T1 B cell morphology0.000005736Highly InformativeDirect
Mammalian Phenotype (MP)abnormal transitional stage T2 B cell morphology0.000008892Highly InformativeDirect
Mammalian Phenotype (MP)decreased B cell proliferation0.0007912Highly InformativeDirect
Mammalian Phenotype (MP)intestinal ulcer0.000981Highly InformativeDirect
Mammalian Phenotype (MP)abnormal interleukin-2 secretion0.005896Highly InformativeInherited
Mammalian Phenotype (MP)increased B cell number0.01135Highly InformativeInherited
Mammalian Phenotype (MP)abnormal iris morphology0.02023Highly InformativeInherited
Mammalian Phenotype (MP)decreased immature B cell number0.04018Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cornea morphology0.07359Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.0000008128Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.01142Least InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.00000001817Moderately InformativeDirect
Worm Phenotype (WP)cell homeostasis metabolism variant0.6218Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.936Moderately InformativeInherited
Worm Phenotype (WP)tail morphology variant0.00000001811InformativeDirect
Worm Phenotype (WP)organism pathogen response variant0.000001423InformativeDirect
Worm Phenotype (WP)aldicarb response variant0.0002578InformativeDirect
Worm Phenotype (WP)protein metabolism variant0.002279InformativeInherited
Worm Phenotype (WP)bacterially unswollen0Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)multi-tissue structure0.3939Least InformativeInherited
Zebrafish Anatomy (ZA)cardiovascular system0.08297Moderately InformativeInherited
Zebrafish Anatomy (ZA)cell0.2583Moderately InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.6029Moderately InformativeInherited
Zebrafish Anatomy (ZA)vasculature0.04019InformativeInherited
Zebrafish Anatomy (ZA)epithelium0.09533Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation0.0000000001976Moderately InformativeDirect
Biological processCell cycle0.000005772Moderately InformativeDirect
Biological processImmunity0.001254Moderately InformativeInherited
Biological processNeurogenesis0.0000000001109InformativeDirect
Biological processEndocytosis0.000004088InformativeDirect
Biological processInnate immunity0.00006427InformativeDirect
Biological processSeptation0.0003771Highly InformativeDirect
Cellular componentCytoplasm0.0000000001827Least InformativeDirect
Cellular componentMembrane0.00001596Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentGolgi apparatus0.00005097Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.0004583Moderately InformativeDirect
Cellular componentMicrotubule0.0005485InformativeDirect
Cellular componentSynapse1InformativeInherited
Cellular componentSynaptosome0.000744Highly InformativeDirect
Coding sequence diversityAlternative splicing0.00000007736Least InformativeDirect
DiseaseProto-oncogene0.000000000002782Moderately InformativeDirect
DomainRepeat0.0000000001105Least InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
DomainZinc-finger0.0000001758Moderately InformativeDirect
DomainSH3 domain0InformativeDirect
DomainSH2 domain0.00000000006736InformativeDirect
DomainImmunoglobulin domain0.0007861InformativeDirect
Molecular functionZinc0.00001836Least InformativeDirect
Molecular functionLipid-binding0.00001303Moderately InformativeDirect
Molecular functionCalmodulin-binding0.0000006744InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationDevelopmental protein0.000005387Moderately InformativeDirect
Post-translational modificationKinase0.09571Moderately InformativeInherited
Post-translational modificationGTPase activation0InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor0InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0.00000009951InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationMyristate0.000185InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR000219 SSF48065 Protein matches
Abstract

The Rho family GTPases Rho, Rac and CDC42 regulate a diverse array of cellular processes. Like all members of the Ras superfamily, the Rho proteins cycle between active GTP-bound and inactive GDP-bound conformational states. Activation of Rho proteins through release of bound GDP and subsequent binding of GTP, is catalyzed by guanine nucleotide exchange factors (GEFs) in the Dbl family. The proteins encoded by members of the Dbl family share a common domain, presented in this entry, of about 200 residues (designated the Dbl homology or DH domain) that has been shown to encode a GEF activity specific for a number of Rho family members. In addition, all family members possess a second, shared domain designated the pleckstrin homology (PH) domain . Trio and its homolog UNC-73 are unique within the Dbl family insomuch as they encode two distinct DH/PH domain modules. The PH domain is invariably located immediately C-terminal to the DH domain and this invariant topography suggests a functional interdependence between these two structural modules. Biochemical data have established the role of the conserved DH domain in Rho GTPase interaction and activation, and the role of the tandem PH domain in intracellular targeting and/or regulation of DH domain function. The DH domain of Dbl has been shown to mediate oligomerization that is mostly homophilic in nature. In addition to the tandem DH/PH domains Dbl family GEFs contain diverse structural motifs like serine/threonine kinase, RBD, PDZ, RGS, IQ, REM, Cdc25 RasGEF, CH, SH2, SH3, EF, spectrin or Ig.

The DH domain is composed of three structurally conserved regions separated by more variable regions. It does not share significant sequence homology with other subtypes of small G-protein GEF motifs such as the Cdc25 domain and the Sec7 domain, which specifically interact with Ras and ARF family small GTPases, respectively, nor with other Rho protein interactive motifs, indicating that the Dbl family proteins are evolutionarily unique. The DH domain is composed of 11 alpha helices that are folded into a flattened, elongated alpha-helix bundle in which two of the three conserved regions, conserved region 1 (CR1) and conserved region 3 (CR3), are exposed near the centre of one surface. CR1 and CR3, together with a part of alpha-6 and the DH/PH junction site, constitute the Rho GTPase interacting pocket.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 10 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a DBL homology domain (DH-domain) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 10 hidden Markov models representing the DBL homology domain (DH-domain) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


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