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DBL homology domain (DH-domain) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   DBL homology domain (DH-domain) [ 48064]
Superfamily:   DBL homology domain (DH-domain) [ 48065]
Families:   DBL homology domain (DH-domain) [ 48066] (10)


Superfamily statistics
Genomes (399) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 11,176 29,660 16
Proteins 10,866 28,838 16


Functional annotation
General category coiled coil
Detailed category The code refers to a 2-stranded_canonical_antiparallel_coiled_coils in the CC+ database. Please click on the link for more information and to visit the CC+ website.

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.000000004393 Least Informative Direct
Biological Process (BP) response to stimulus 0.0000009716 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cell communication 0 Moderately Informative Direct
Biological Process (BP) regulation of signaling 0 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0 Moderately Informative Direct
Biological Process (BP) cell communication 0.0000000001782 Moderately Informative Direct
Biological Process (BP) cellular developmental process 0.00000002866 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.0000001193 Moderately Informative Direct
Biological Process (BP) single organism signaling 0.0000004093 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.000002414 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.000008163 Moderately Informative Direct
Biological Process (BP) system development 0.00005546 Moderately Informative Direct
Biological Process (BP) immune system process 0.0008525 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.06173 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.7941 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.02604 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.9048 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.6954 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.9701 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.8728 Moderately Informative Inherited
Biological Process (BP) reproduction 0.05243 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.9247 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0 Informative Direct
Biological Process (BP) actin filament-based process 0 Informative Direct
Biological Process (BP) regulation of intracellular signal transduction 0 Informative Direct
Biological Process (BP) regulation of apoptotic process 0 Informative Direct
Biological Process (BP) regulation of nervous system development 0 Informative Direct
Biological Process (BP) cytoskeleton organization 0.0000000000003179 Informative Direct
Biological Process (BP) locomotion 0.000000000000587 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0.00000000001918 Informative Direct
Biological Process (BP) post-embryonic development 0.0000000001218 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0.0000000002425 Informative Direct
Biological Process (BP) pigment metabolic process 0.0000000007185 Informative Direct
Biological Process (BP) positive regulation of signal transduction 0.000000007052 Informative Direct
Biological Process (BP) animal organ morphogenesis 0.0000000235 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.0000003015 Informative Direct
Biological Process (BP) positive regulation of cell death 0.0000004438 Informative Direct
Biological Process (BP) secondary metabolic process 0.0000005543 Informative Direct
Biological Process (BP) regulation of hydrolase activity 0.000000692 Informative Direct
Biological Process (BP) intracellular signal transduction 0.000001635 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.00001676 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.00002657 Informative Direct
Biological Process (BP) supramolecular fiber organization 0.00009061 Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.003968 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.00102 Informative Inherited
Biological Process (BP) response to cytokine 0.005522 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.1613 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.1587 Informative Inherited
Biological Process (BP) growth 0.0778 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) tissue development 0.1653 Informative Inherited
Biological Process (BP) response to nitrogen compound 0.7562 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.2974 Informative Inherited
Biological Process (BP) microtubule-based process 0.0291 Informative Inherited
Biological Process (BP) organelle assembly 0.4448 Informative Inherited
Biological Process (BP) regulation of cell differentiation 0.005344 Informative Inherited
Biological Process (BP) generation of neurons 0.05988 Informative Inherited
Biological Process (BP) reproductive system development 1 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 0.5094 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) regulation of growth 0.01805 Informative Inherited
Biological Process (BP) positive regulation of developmental process 1 Informative Inherited
Biological Process (BP) cell-cell signaling 0.6541 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.01726 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.004435 Informative Inherited
Biological Process (BP) regulation of phosphorylation 0.214 Informative Inherited
Biological Process (BP) immune effector process 0.002351 Informative Inherited
Biological Process (BP) immune response 0.3028 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 0.01415 Informative Inherited
Biological Process (BP) regulation of protein modification process 0.05166 Informative Inherited
Biological Process (BP) regulation of cytokine production 1 Informative Inherited
Biological Process (BP) regulation of cell cycle 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.08025 Informative Inherited
Biological Process (BP) embryo development 0.8823 Informative Inherited
Biological Process (BP) cell activation 0.8772 Informative Inherited
Biological Process (BP) behavior 0.004266 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.6794 Informative Inherited
Biological Process (BP) central nervous system development 1 Informative Inherited
Biological Process (BP) cell development 0.01772 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.8335 Informative Inherited
Biological Process (BP) single organism reproductive process 0.7226 Informative Inherited
Biological Process (BP) multi-organism reproductive process 0.03794 Informative Inherited
Biological Process (BP) cell cycle process 0.09273 Informative Inherited
Biological Process (BP) membrane organization 1 Informative Inherited
Biological Process (BP) plasma membrane bounded cell projection organization 0 Highly Informative Direct
Biological Process (BP) regulation of GTPase activity 0 Highly Informative Direct
Biological Process (BP) small GTPase mediated signal transduction 0 Highly Informative Direct
Biological Process (BP) post-embryonic animal morphogenesis 0 Highly Informative Direct
Biological Process (BP) positive regulation of cellular component biogenesis 0 Highly Informative Direct
Biological Process (BP) positive regulation of apoptotic process 0 Highly Informative Direct
Biological Process (BP) appendage development 0 Highly Informative Direct
Biological Process (BP) positive regulation of supramolecular fiber organization 0.0000000000001747 Highly Informative Direct
Biological Process (BP) tube morphogenesis 0.0000000000003449 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 0.00000000005071 Highly Informative Direct
Biological Process (BP) regulation of cell shape 0.000000003207 Highly Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0.000000004942 Highly Informative Direct
Biological Process (BP) chemotaxis 0.000000008959 Highly Informative Direct
Biological Process (BP) morphogenesis of an epithelium 0.000000009827 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.0000001835 Highly Informative Direct
Biological Process (BP) phagocytosis 0.000001084 Highly Informative Direct
Biological Process (BP) neuron development 0.000002366 Highly Informative Direct
Biological Process (BP) cell projection assembly 0.000006783 Highly Informative Direct
Biological Process (BP) innate immune response 0.000007387 Highly Informative Direct
Biological Process (BP) gastrulation 0.00001937 Highly Informative Direct
Biological Process (BP) cell division 0.00005337 Highly Informative Direct
Biological Process (BP) negative regulation of nervous system development 0.000106 Highly Informative Direct
Biological Process (BP) regulation of protein polymerization 0.0007064 Highly Informative Direct
Biological Process (BP) cell growth 0.0008271 Highly Informative Direct
Biological Process (BP) regulation of circadian rhythm 0.2969 Highly Informative Inherited
Biological Process (BP) regulation of protein complex disassembly 0.6141 Highly Informative Inherited
Biological Process (BP) developmental growth involved in morphogenesis 0.04795 Highly Informative Inherited
Biological Process (BP) cellular response to organonitrogen compound 0.03398 Highly Informative Inherited
Biological Process (BP) muscle structure development 0.7782 Highly Informative Inherited
Biological Process (BP) sex differentiation 0.004315 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.0326 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.0194 Highly Informative Inherited
Biological Process (BP) positive regulation of nervous system development 0.01506 Highly Informative Inherited
Biological Process (BP) regulation of cell size 0.168 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.02056 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.004185 Highly Informative Inherited
Biological Process (BP) positive regulation of cell development 0.5793 Highly Informative Inherited
Biological Process (BP) regulation of cell growth 1 Highly Informative Inherited
Biological Process (BP) actomyosin structure organization 0.998 Highly Informative Inherited
Biological Process (BP) meiotic cell cycle 0.1648 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 1 Highly Informative Inherited
Biological Process (BP) positive regulation of MAPK cascade 1 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.6944 Highly Informative Inherited
Biological Process (BP) maintenance of location 0.08123 Highly Informative Inherited
Biological Process (BP) regulation of cell division 0.02872 Highly Informative Inherited
Biological Process (BP) regulation of microtubule-based process 0.1658 Highly Informative Inherited
Biological Process (BP) regulation of actin polymerization or depolymerization 1 Highly Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.4404 Highly Informative Inherited
Biological Process (BP) hemostasis 0.01685 Highly Informative Inherited
Biological Process (BP) wound healing 0.08023 Highly Informative Inherited
Biological Process (BP) coagulation 0.1207 Highly Informative Inherited
Biological Process (BP) brain development 0.2639 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.6647 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.2454 Highly Informative Inherited
Biological Process (BP) germ cell development 1 Highly Informative Inherited
Biological Process (BP) nuclear division 0.02614 Highly Informative Inherited
Biological Process (BP) microtubule cytoskeleton organization 1 Highly Informative Inherited
Biological Process (BP) endomembrane system organization 0.06505 Highly Informative Inherited
Biological Process (BP) negative regulation of cytoskeleton organization 1 Highly Informative Inherited
Biological Process (BP) negative regulation of supramolecular fiber organization 1 Highly Informative Inherited
Biological Process (BP) microtubule-based movement 0.923 Highly Informative Inherited
Biological Process (BP) cell proliferation 0.6127 Highly Informative Inherited
Molecular Function (MF) binding 0.00177 Least Informative Inherited
Molecular Function (MF) molecular function regulator 0 Moderately Informative Direct
Molecular Function (MF) structural molecule activity 0.001278 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.1884 Moderately Informative Inherited
Molecular Function (MF) enzyme binding 0 Informative Direct
Molecular Function (MF) enzyme activator activity 0.00000000002742 Informative Direct
Molecular Function (MF) phospholipid binding 0.000002793 Informative Direct
Molecular Function (MF) receptor binding 0.4998 Informative Inherited
Molecular Function (MF) small GTPase binding 0 Highly Informative Direct
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0 Highly Informative Direct
Molecular Function (MF) GTPase regulator activity 0.0000000002811 Highly Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0.0003664 Least Informative Direct
Cellular Component (CC) membrane 0.3631 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.007953 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.0001534 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.01879 Moderately Informative Inherited
Cellular Component (CC) cytoplasmic region 0 Informative Direct
Cellular Component (CC) extrinsic component of membrane 0.00000000000001784 Informative Direct
Cellular Component (CC) supramolecular polymer 0.00000000008029 Informative Direct
Cellular Component (CC) side of membrane 0.000000006639 Informative Direct
Cellular Component (CC) synapse 0.0000002964 Informative Direct
Cellular Component (CC) cell surface 0.5341 Informative Inherited
Cellular Component (CC) apical part of cell 0.002155 Informative Inherited
Cellular Component (CC) actin cytoskeleton 0.04365 Informative Inherited
Cellular Component (CC) neuron projection 0.04168 Informative Inherited
Cellular Component (CC) plasma membrane bounded cell projection part 1 Informative Inherited
Cellular Component (CC) cell division site part 0 Highly Informative Direct
Cellular Component (CC) extrinsic component of cytoplasmic side of plasma membrane 0 Highly Informative Direct
Cellular Component (CC) lamellipodium 0.0000002046 Highly Informative Direct
Cellular Component (CC) ruffle 0.0000003913 Highly Informative Direct
Cellular Component (CC) contractile fiber part 0.0000006533 Highly Informative Direct
Cellular Component (CC) growth cone 0.00002041 Highly Informative Direct
Cellular Component (CC) cortical actin cytoskeleton 0.00005035 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the face0.6489Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.7546Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.7745Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin adnexa morphology0.1772Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin morphology0.845Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the scalp hair0.04115InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the forehead0.1402InformativeInherited
Phenotypic Abnormality (PA)High anterior hairline0.0001288Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormally lax or hyperextensible skin0.005018Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype0.4452Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.5812Least InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.01614Moderately InformativeInherited
Mammalian Phenotype (MP)decreased hematopoietic cell number0.1307Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte cell number0.1483Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.2109Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.4689Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.5757Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.6327Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.6468Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.6724Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.7316Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal B cell proliferation0.005323InformativeInherited
Mammalian Phenotype (MP)abnormal uvea morphology0.06284InformativeInherited
Mammalian Phenotype (MP)abnormal mature B cell morphology0.06762InformativeInherited
Mammalian Phenotype (MP)increased leukocyte cell number0.1586InformativeInherited
Mammalian Phenotype (MP)abnormal intestine morphology0.2369InformativeInherited
Mammalian Phenotype (MP)abnormal anterior eye segment morphology0.2631InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin secretion0.2641InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation0.3067InformativeInherited
Mammalian Phenotype (MP)abnormal transitional stage T1 B cell morphology0.000007338Highly InformativeDirect
Mammalian Phenotype (MP)abnormal transitional stage T2 B cell morphology0.00001116Highly InformativeDirect
Mammalian Phenotype (MP)decreased B cell proliferation0.0008043Highly InformativeDirect
Mammalian Phenotype (MP)intestinal ulcer0.0009916Highly InformativeDirect
Mammalian Phenotype (MP)abnormal interleukin-2 secretion0.005756Highly InformativeInherited
Mammalian Phenotype (MP)increased B cell number0.01283Highly InformativeInherited
Mammalian Phenotype (MP)abnormal iris morphology0.02333Highly InformativeInherited
Mammalian Phenotype (MP)decreased immature B cell number0.03858Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cornea morphology0.09381Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.0000003977Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.002344Least InformativeInherited
Worm Phenotype (WP)organ system morphology variant0.006246Least InformativeInherited
Worm Phenotype (WP)cell morphology variant0.0161Least InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.000000006894Moderately InformativeDirect
Worm Phenotype (WP)cell component morphology variant0.1747Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.7647Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.9211Moderately InformativeInherited
Worm Phenotype (WP)tail morphology variant0.0000000218InformativeDirect
Worm Phenotype (WP)organism pathogen response variant0.00000156InformativeDirect
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.00008471InformativeDirect
Worm Phenotype (WP)aldicarb response variant0.0002207InformativeDirect
Worm Phenotype (WP)mitochondria morphology variant0.0006772InformativeDirect
Worm Phenotype (WP)protein degradation variant0.0009033InformativeDirect
Worm Phenotype (WP)muscle cell physiology variant0.004923InformativeInherited
Worm Phenotype (WP)bacterially unswollen0Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)multi-tissue structure0.6218Least InformativeInherited
Zebrafish Anatomy (ZA)cardiovascular system0.2119Moderately InformativeInherited
Zebrafish Anatomy (ZA)cell0.2793Moderately InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.6207Moderately InformativeInherited
Zebrafish Anatomy (ZA)vasculature0.1341InformativeInherited
Zebrafish Anatomy (ZA)epithelium0.09573Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation0.0000000003003Moderately InformativeDirect
Biological processCell cycle0.000006522Moderately InformativeDirect
Biological processImmunity0.001421Moderately InformativeInherited
Biological processNeurogenesis0.0000000001351InformativeDirect
Biological processEndocytosis0.000004388InformativeDirect
Biological processInnate immunity0.00007038InformativeDirect
Biological processSeptation0.0003767Highly InformativeDirect
Cellular componentCytoplasm0.00000000001296Least InformativeDirect
Cellular componentMembrane0.000005473Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentGolgi apparatus0.00006718Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.0006617Moderately InformativeDirect
Cellular componentMicrotubule0.0006681InformativeDirect
Cellular componentSynapse1InformativeInherited
Cellular componentSynaptosome0.000825Highly InformativeDirect
Coding sequence diversityAlternative splicing0.00000006304Least InformativeDirect
DiseaseProto-oncogene0.000000000003786Moderately InformativeDirect
DomainRepeat0.00000000003784Least InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
DomainZinc-finger0.0000002807Moderately InformativeDirect
DomainSH3 domain0InformativeDirect
DomainSH2 domain0.00000000007948InformativeDirect
DomainImmunoglobulin domain0.00004679InformativeDirect
Molecular functionZinc0.00002402Least InformativeDirect
Molecular functionLipid-binding0.00001548Moderately InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationDevelopmental protein0.0000007155Moderately InformativeDirect
Post-translational modificationKinase0.05793Moderately InformativeInherited
Post-translational modificationGTPase activation0InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor0InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0.000000002147InformativeDirect
Post-translational modificationCalmodulin-binding0.000001513InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationMyristate0.0001962InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR000219 SSF48065 Protein matches
Abstract

The Rho family GTPases Rho, Rac and CDC42 regulate a diverse array of cellular processes. Like all members of the Ras superfamily, the Rho proteins cycle between active GTP-bound and inactive GDP-bound conformational states. Activation of Rho proteins through release of bound GDP and subsequent binding of GTP, is catalyzed by guanine nucleotide exchange factors (GEFs) in the Dbl family. The proteins encoded by members of the Dbl family share a common domain, presented in this entry, of about 200 residues (designated the Dbl homology or DH domain) that has been shown to encode a GEF activity specific for a number of Rho family members. In addition, all family members possess a second, shared domain designated the pleckstrin homology (PH) domain . Trio and its homolog UNC-73 are unique within the Dbl family insomuch as they encode two distinct DH/PH domain modules. The PH domain is invariably located immediately C-terminal to the DH domain and this invariant topography suggests a functional interdependence between these two structural modules. Biochemical data have established the role of the conserved DH domain in Rho GTPase interaction and activation, and the role of the tandem PH domain in intracellular targeting and/or regulation of DH domain function. The DH domain of Dbl has been shown to mediate oligomerization that is mostly homophilic in nature. In addition to the tandem DH/PH domains Dbl family GEFs contain diverse structural motifs like serine/threonine kinase, RBD, PDZ, RGS, IQ, REM, Cdc25 RasGEF, CH, SH2, SH3, EF, spectrin or Ig.

The DH domain is composed of three structurally conserved regions separated by more variable regions. It does not share significant sequence homology with other subtypes of small G-protein GEF motifs such as the Cdc25 domain and the Sec7 domain, which specifically interact with Ras and ARF family small GTPases, respectively, nor with other Rho protein interactive motifs, indicating that the Dbl family proteins are evolutionarily unique. The DH domain is composed of 11 alpha helices that are folded into a flattened, elongated alpha-helix bundle in which two of the three conserved regions, conserved region 1 (CR1) and conserved region 3 (CR3), are exposed near the centre of one surface. CR1 and CR3, together with a part of alpha-6 and the DH/PH junction site, constitute the Rho GTPase interacting pocket.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 10 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a DBL homology domain (DH-domain) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 10 hidden Markov models representing the DBL homology domain (DH-domain) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


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