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DBL homology domain (DH-domain) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   DBL homology domain (DH-domain) [ 48064]
Superfamily:   DBL homology domain (DH-domain) [ 48065]
Families:   DBL homology domain (DH-domain) [ 48066] (10)


Superfamily statistics
Genomes (401) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 11,355 36,479 16
Proteins 11,038 35,480 16


Functional annotation
General category coiled coil
Detailed category The code refers to a 2-stranded_canonical_antiparallel_coiled_coils in the CC+ database. Please click on the link for more information and to visit the CC+ website.

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype0.4438Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.5799Least InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.01587Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.2099Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.4692Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.4719Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.573Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.6317Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.646Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.674Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.7305Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal B cell proliferation0.005212InformativeInherited
Mammalian Phenotype (MP)abnormal uvea morphology0.06104InformativeInherited
Mammalian Phenotype (MP)abnormal mature B cell morphology0.06742InformativeInherited
Mammalian Phenotype (MP)increased leukocyte cell number0.158InformativeInherited
Mammalian Phenotype (MP)abnormal intestine morphology0.2376InformativeInherited
Mammalian Phenotype (MP)abnormal anterior eye segment morphology0.2603InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin secretion0.2631InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation0.3079InformativeInherited
Mammalian Phenotype (MP)abnormal transitional stage T1 B cell morphology0.000007372Highly InformativeDirect
Mammalian Phenotype (MP)abnormal transitional stage T2 B cell morphology0.00001119Highly InformativeDirect
Mammalian Phenotype (MP)decreased B cell proliferation0.000773Highly InformativeDirect
Mammalian Phenotype (MP)intestinal ulcer0.0009949Highly InformativeDirect
Mammalian Phenotype (MP)abnormal interleukin-2 secretion0.00588Highly InformativeInherited
Mammalian Phenotype (MP)increased B cell number0.01268Highly InformativeInherited
Mammalian Phenotype (MP)abnormal iris morphology0.02278Highly InformativeInherited
Mammalian Phenotype (MP)decreased immature B cell number0.03881Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cornea morphology0.09406Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.000001204Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.002526Least InformativeInherited
Worm Phenotype (WP)organ system morphology variant0.006817Least InformativeInherited
Worm Phenotype (WP)cell morphology variant0.01805Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.05544Least InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.00000000765Moderately InformativeDirect
Worm Phenotype (WP)metabolic pathway variant0.05281Moderately InformativeInherited
Worm Phenotype (WP)cell component morphology variant0.1728Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.7908Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.8387Moderately InformativeInherited
Worm Phenotype (WP)tail morphology variant0.00000002555InformativeDirect
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.00008508InformativeDirect
Worm Phenotype (WP)organism pathogen response variant0.0000904InformativeDirect
Worm Phenotype (WP)aldicarb response variant0.00023InformativeDirect
Worm Phenotype (WP)mitochondria morphology variant0.0006303InformativeDirect
Worm Phenotype (WP)protein degradation variant0.0009457InformativeDirect
Worm Phenotype (WP)muscle cell physiology variant0.004888InformativeInherited
Worm Phenotype (WP)bacterially unswollen0Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0.4429Least InformativeInherited
Zebrafish Anatomy (ZA)multi-tissue structure0.7806Least InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.5281Moderately InformativeInherited
Zebrafish Anatomy (ZA)cardiovascular system0.5694Moderately InformativeInherited
Zebrafish Anatomy (ZA)epithelium0.1288Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect

Document: EC annotation of SCOP domains

InterPro annotation
Cross references IPR000219 SSF48065 Protein matches
Abstract

The Rho family GTPases Rho, Rac and CDC42 regulate a diverse array of cellular processes. Like all members of the Ras superfamily, the Rho proteins cycle between active GTP-bound and inactive GDP-bound conformational states. Activation of Rho proteins through release of bound GDP and subsequent binding of GTP, is catalyzed by guanine nucleotide exchange factors (GEFs) in the Dbl family. The proteins encoded by members of the Dbl family share a common domain, presented in this entry, of about 200 residues (designated the Dbl homology or DH domain) that has been shown to encode a GEF activity specific for a number of Rho family members. In addition, all family members possess a second, shared domain designated the pleckstrin homology (PH) domain . Trio and its homolog UNC-73 are unique within the Dbl family insomuch as they encode two distinct DH/PH domain modules. The PH domain is invariably located immediately C-terminal to the DH domain and this invariant topography suggests a functional interdependence between these two structural modules. Biochemical data have established the role of the conserved DH domain in Rho GTPase interaction and activation, and the role of the tandem PH domain in intracellular targeting and/or regulation of DH domain function. The DH domain of Dbl has been shown to mediate oligomerization that is mostly homophilic in nature. In addition to the tandem DH/PH domains Dbl family GEFs contain diverse structural motifs like serine/threonine kinase, RBD, PDZ, RGS, IQ, REM, Cdc25 RasGEF, CH, SH2, SH3, EF, spectrin or Ig.

The DH domain is composed of three structurally conserved regions separated by more variable regions. It does not share significant sequence homology with other subtypes of small G-protein GEF motifs such as the Cdc25 domain and the Sec7 domain, which specifically interact with Ras and ARF family small GTPases, respectively, nor with other Rho protein interactive motifs, indicating that the Dbl family proteins are evolutionarily unique. The DH domain is composed of 11 alpha helices that are folded into a flattened, elongated alpha-helix bundle in which two of the three conserved regions, conserved region 1 (CR1) and conserved region 3 (CR3), are exposed near the centre of one surface. CR1 and CR3, together with a part of alpha-6 and the DH/PH junction site, constitute the Rho GTPase interacting pocket.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 10 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a DBL homology domain (DH-domain) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 10 hidden Markov models representing the DBL homology domain (DH-domain) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]