SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.


DBL homology domain (DH-domain) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   DBL homology domain (DH-domain) [ 48064]
Superfamily:   DBL homology domain (DH-domain) [ 48065]
Families:   DBL homology domain (DH-domain) [ 48066] (10)


Superfamily statistics
Genomes (399) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 11,176 29,660 16
Proteins 10,866 28,838 16


Functional annotation
General category coiled coil
Detailed category The code refers to a 2-stranded_canonical_antiparallel_coiled_coils in the CC+ database. Please click on the link for more information and to visit the CC+ website.

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.00000001413 Least Informative Direct
Biological Process (BP) response to stimulus 0.00001499 Least Informative Direct
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of signaling 0 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 0 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 0 Moderately Informative Direct
Biological Process (BP) cell communication 0.0000000005693 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.000001047 Moderately Informative Direct
Biological Process (BP) single organism signaling 0.000001536 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.00001 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.00001065 Moderately Informative Direct
Biological Process (BP) immune system process 0.0003796 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.7401 Moderately Informative Inherited
Biological Process (BP) animal organ development 0.01351 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.04259 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.06519 Moderately Informative Inherited
Biological Process (BP) defense response 0.03718 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.9595 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.8203 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.9557 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.04317 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.8791 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.1534 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.8209 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.8668 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0 Informative Direct
Biological Process (BP) regulation of nervous system development 0 Informative Direct
Biological Process (BP) regulation of apoptotic process 0 Informative Direct
Biological Process (BP) actin cytoskeleton organization 0 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0 Informative Direct
Biological Process (BP) locomotion 0.000000000004455 Informative Direct
Biological Process (BP) post-embryonic development 0.00000000000478 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0.0000000000212 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0.00000000006558 Informative Direct
Biological Process (BP) positive regulation of signal transduction 0.0000000002391 Informative Direct
Biological Process (BP) pigment metabolic process 0.000000001414 Informative Direct
Biological Process (BP) localization of cell 0.000000007487 Informative Direct
Biological Process (BP) animal organ morphogenesis 0.00000001936 Informative Direct
Biological Process (BP) epithelium development 0.000000074 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.0000001235 Informative Direct
Biological Process (BP) regulation of hydrolase activity 0.0000006146 Informative Direct
Biological Process (BP) secondary metabolic process 0.0000009018 Informative Direct
Biological Process (BP) supramolecular fiber organization 0.000002699 Informative Direct
Biological Process (BP) intracellular signal transduction 0.000002942 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.00002436 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.00009541 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0.001751 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.171 Informative Inherited
Biological Process (BP) growth 0.03643 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) regulation of cell differentiation 0.01132 Informative Inherited
Biological Process (BP) embryo development 0.772 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.006438 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.02417 Informative Inherited
Biological Process (BP) microtubule-based process 0.008878 Informative Inherited
Biological Process (BP) organelle assembly 0.5814 Informative Inherited
Biological Process (BP) reproductive system development 1 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.6016 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 0.5693 Informative Inherited
Biological Process (BP) regulation of growth 0.02571 Informative Inherited
Biological Process (BP) positive regulation of developmental process 1 Informative Inherited
Biological Process (BP) generation of neurons 0.05399 Informative Inherited
Biological Process (BP) immune response 0.344 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.2913 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.03122 Informative Inherited
Biological Process (BP) immune effector process 0.007083 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.00426 Informative Inherited
Biological Process (BP) regulation of phosphorylation 0.2214 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 0.0252 Informative Inherited
Biological Process (BP) regulation of protein modification process 0.08612 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) regulation of cytokine production 1 Informative Inherited
Biological Process (BP) cell cycle process 0.104 Informative Inherited
Biological Process (BP) response to nitrogen compound 0.7801 Informative Inherited
Biological Process (BP) regulation of cell cycle 1 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) single organism reproductive process 0.6339 Informative Inherited
Biological Process (BP) response to wounding 0.4327 Informative Inherited
Biological Process (BP) cell activation 0.8928 Informative Inherited
Biological Process (BP) behavior 0.009009 Informative Inherited
Biological Process (BP) central nervous system development 1 Informative Inherited
Biological Process (BP) cell development 0.04786 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.6847 Informative Inherited
Biological Process (BP) multi-organism reproductive process 0.02291 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.1661 Informative Inherited
Biological Process (BP) regulation of GTPase activity 0 Highly Informative Direct
Biological Process (BP) plasma membrane bounded cell projection organization 0 Highly Informative Direct
Biological Process (BP) appendage development 0 Highly Informative Direct
Biological Process (BP) small GTPase mediated signal transduction 0 Highly Informative Direct
Biological Process (BP) post-embryonic animal morphogenesis 0 Highly Informative Direct
Biological Process (BP) positive regulation of apoptotic process 0 Highly Informative Direct
Biological Process (BP) positive regulation of cellular component biogenesis 0 Highly Informative Direct
Biological Process (BP) tube morphogenesis 0.00000000000002436 Highly Informative Direct
Biological Process (BP) positive regulation of supramolecular fiber organization 0.0000000000001187 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 0.00000000008575 Highly Informative Direct
Biological Process (BP) regulation of cell shape 0.0000000001515 Highly Informative Direct
Biological Process (BP) morphogenesis of an epithelium 0.000000001221 Highly Informative Direct
Biological Process (BP) cytokinesis 0.00000000283 Highly Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0.000000004797 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.000000097 Highly Informative Direct
Biological Process (BP) gastrulation 0.0000004426 Highly Informative Direct
Biological Process (BP) phagocytosis 0.000002639 Highly Informative Direct
Biological Process (BP) cell projection assembly 0.000007041 Highly Informative Direct
Biological Process (BP) neuron development 0.000008941 Highly Informative Direct
Biological Process (BP) innate immune response 0.00001523 Highly Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.00007271 Highly Informative Direct
Biological Process (BP) cell growth 0.0001633 Highly Informative Direct
Biological Process (BP) negative regulation of nervous system development 0.0002259 Highly Informative Direct
Biological Process (BP) regulation of protein polymerization 0.0007607 Highly Informative Direct
Biological Process (BP) regulation of circadian rhythm 0.3418 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.6746 Highly Informative Inherited
Biological Process (BP) regulation of protein complex disassembly 0.8007 Highly Informative Inherited
Biological Process (BP) developmental growth involved in morphogenesis 0.02158 Highly Informative Inherited
Biological Process (BP) response to growth factor 0.003211 Highly Informative Inherited
Biological Process (BP) cellular response to organonitrogen compound 0.03365 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.01612 Highly Informative Inherited
Biological Process (BP) maintenance of location 0.07615 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.02015 Highly Informative Inherited
Biological Process (BP) microtubule cytoskeleton organization 1 Highly Informative Inherited
Biological Process (BP) sex differentiation 0.008971 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.006488 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.03217 Highly Informative Inherited
Biological Process (BP) positive regulation of nervous system development 0.02264 Highly Informative Inherited
Biological Process (BP) regulation of cell size 0.2375 Highly Informative Inherited
Biological Process (BP) cell-cell signaling 0.6864 Highly Informative Inherited
Biological Process (BP) actomyosin structure organization 1 Highly Informative Inherited
Biological Process (BP) actin filament organization 0.6948 Highly Informative Inherited
Biological Process (BP) positive regulation of MAPK cascade 1 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 1 Highly Informative Inherited
Biological Process (BP) regulation of cell division 0.03201 Highly Informative Inherited
Biological Process (BP) negative regulation of cytoskeleton organization 1 Highly Informative Inherited
Biological Process (BP) regulation of actin polymerization or depolymerization 1 Highly Informative Inherited
Biological Process (BP) hemostasis 0.01821 Highly Informative Inherited
Biological Process (BP) wound healing 0.1226 Highly Informative Inherited
Biological Process (BP) coagulation 0.1437 Highly Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 0.3679 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.756 Highly Informative Inherited
Biological Process (BP) nuclear division 0.0339 Highly Informative Inherited
Biological Process (BP) meiotic cell cycle 0.192 Highly Informative Inherited
Biological Process (BP) endomembrane system organization 0.0683 Highly Informative Inherited
Biological Process (BP) regulation of microtubule-based process 0.2039 Highly Informative Inherited
Biological Process (BP) negative regulation of supramolecular fiber organization 1 Highly Informative Inherited
Biological Process (BP) microtubule-based movement 0.6687 Highly Informative Inherited
Biological Process (BP) cell proliferation 0.5182 Highly Informative Inherited
Molecular Function (MF) binding 0.01123 Least Informative Inherited
Molecular Function (MF) molecular function regulator 0 Moderately Informative Direct
Molecular Function (MF) structural molecule activity 0.001989 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.2559 Moderately Informative Inherited
Molecular Function (MF) enzyme binding 0 Informative Direct
Molecular Function (MF) enzyme activator activity 0.00000000001354 Informative Direct
Molecular Function (MF) phospholipid binding 0.000006576 Informative Direct
Molecular Function (MF) receptor binding 0.5325 Informative Inherited
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0 Highly Informative Direct
Molecular Function (MF) small GTPase binding 0 Highly Informative Direct
Molecular Function (MF) GTPase regulator activity 0.00000000009589 Highly Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0.0001191 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.0009503 Least Informative Direct
Cellular Component (CC) membrane 0.4521 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.0004207 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.01371 Moderately Informative Inherited
Cellular Component (CC) cytoplasmic region 0 Informative Direct
Cellular Component (CC) extrinsic component of membrane 0.00000000000008179 Informative Direct
Cellular Component (CC) supramolecular polymer 0.000000000004904 Informative Direct
Cellular Component (CC) side of membrane 0.00000002159 Informative Direct
Cellular Component (CC) apical part of cell 0.0003627 Informative Direct
Cellular Component (CC) plasma membrane region 0.0003965 Informative Direct
Cellular Component (CC) cell surface 0.6278 Informative Inherited
Cellular Component (CC) actin cytoskeleton 0.02477 Informative Inherited
Cellular Component (CC) neuron projection 0.06012 Informative Inherited
Cellular Component (CC) plasma membrane bounded cell projection part 1 Informative Inherited
Cellular Component (CC) cell division site part 0 Highly Informative Direct
Cellular Component (CC) extrinsic component of cytoplasmic side of plasma membrane 0 Highly Informative Direct
Cellular Component (CC) contractile ring 0.000000000002179 Highly Informative Direct
Cellular Component (CC) ruffle 0.0000002295 Highly Informative Direct
Cellular Component (CC) lamellipodium 0.0000005743 Highly Informative Direct
Cellular Component (CC) basal part of cell 0.000001928 Highly Informative Direct
Cellular Component (CC) growth cone 0.00002321 Highly Informative Direct
Cellular Component (CC) cortical cytoskeleton 0.0002572 Highly Informative Direct
Cellular Component (CC) sarcomere 1 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation0.0000000003024Moderately InformativeDirect
Biological processCell cycle0.000006628Moderately InformativeDirect
Biological processImmunity0.001743Moderately InformativeInherited
Biological processNeurogenesis0.000000000137InformativeDirect
Biological processEndocytosis0.000004329InformativeDirect
Biological processInnate immunity0.00007226InformativeDirect
Biological processSeptation0.0003666Highly InformativeDirect
Cellular componentCytoplasm0.00000000001085Least InformativeDirect
Cellular componentMembrane0.000006133Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentGolgi apparatus0.00006638Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.0006586Moderately InformativeDirect
Cellular componentMicrotubule0.0006706InformativeDirect
Cellular componentSynapse1InformativeInherited
Cellular componentSynaptosome0.0008177Highly InformativeDirect
Coding sequence diversityAlternative splicing0.00000004844Least InformativeDirect
DiseaseProto-oncogene0.000000000003629Moderately InformativeDirect
DomainRepeat0.00000000003538Least InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
DomainZinc-finger0.0000002582Moderately InformativeDirect
DomainSH3 domain0InformativeDirect
DomainSH2 domain0.0000000000755InformativeDirect
DomainImmunoglobulin domain0.00006522InformativeDirect
Molecular functionZinc0.00002357Least InformativeDirect
Molecular functionLipid-binding0.00001563Moderately InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationDevelopmental protein0.0000007192Moderately InformativeDirect
Post-translational modificationKinase0.05744Moderately InformativeInherited
Post-translational modificationGTPase activation0InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor0InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0.000000002162InformativeDirect
Post-translational modificationCalmodulin-binding0.00000149InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationMyristate0.0001946InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR000219 SSF48065 Protein matches
Abstract

The Rho family GTPases Rho, Rac and CDC42 regulate a diverse array of cellular processes. Like all members of the Ras superfamily, the Rho proteins cycle between active GTP-bound and inactive GDP-bound conformational states. Activation of Rho proteins through release of bound GDP and subsequent binding of GTP, is catalyzed by guanine nucleotide exchange factors (GEFs) in the Dbl family. The proteins encoded by members of the Dbl family share a common domain, presented in this entry, of about 200 residues (designated the Dbl homology or DH domain) that has been shown to encode a GEF activity specific for a number of Rho family members. In addition, all family members possess a second, shared domain designated the pleckstrin homology (PH) domain . Trio and its homolog UNC-73 are unique within the Dbl family insomuch as they encode two distinct DH/PH domain modules. The PH domain is invariably located immediately C-terminal to the DH domain and this invariant topography suggests a functional interdependence between these two structural modules. Biochemical data have established the role of the conserved DH domain in Rho GTPase interaction and activation, and the role of the tandem PH domain in intracellular targeting and/or regulation of DH domain function. The DH domain of Dbl has been shown to mediate oligomerization that is mostly homophilic in nature. In addition to the tandem DH/PH domains Dbl family GEFs contain diverse structural motifs like serine/threonine kinase, RBD, PDZ, RGS, IQ, REM, Cdc25 RasGEF, CH, SH2, SH3, EF, spectrin or Ig.

The DH domain is composed of three structurally conserved regions separated by more variable regions. It does not share significant sequence homology with other subtypes of small G-protein GEF motifs such as the Cdc25 domain and the Sec7 domain, which specifically interact with Ras and ARF family small GTPases, respectively, nor with other Rho protein interactive motifs, indicating that the Dbl family proteins are evolutionarily unique. The DH domain is composed of 11 alpha helices that are folded into a flattened, elongated alpha-helix bundle in which two of the three conserved regions, conserved region 1 (CR1) and conserved region 3 (CR3), are exposed near the centre of one surface. CR1 and CR3, together with a part of alpha-6 and the DH/PH junction site, constitute the Rho GTPase interacting pocket.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 10 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a DBL homology domain (DH-domain) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 10 hidden Markov models representing the DBL homology domain (DH-domain) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]