SUPERFAMILY 1.75 HMM library and genome assignments server

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DBL homology domain (DH-domain) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   DBL homology domain (DH-domain) [ 48064]
Superfamily:   DBL homology domain (DH-domain) [ 48065]
Families:   DBL homology domain (DH-domain) [ 48066] (10)


Superfamily statistics
Genomes (393) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 10,976 12,001 16
Proteins 10,667 11,712 16


Functional annotation
General category coiled coil
Detailed category The code refers to a 2-stranded_canonical_antiparallel_coiled_coils in the CC+ database. Please click on the link for more information and to visit the CC+ website.

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process0.000000052790.00000000008402Least InformativeDirect
Biological Process (BP)response to stimulus0.000059180Least InformativeDirect
Biological Process (BP)multicellular organismal process0.0028990Least InformativeInherited
Biological Process (BP)developmental process0.0012460Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.0025810.00000000000001778Least InformativeInherited
Biological Process (BP)single-organism cellular process0.0037590Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.042620Least InformativeInherited
Biological Process (BP)regulation of signal transduction0.0000000000038930Moderately InformativeDirect
Biological Process (BP)negative regulation of cellular process0.021621Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.30070.0000002769Moderately InformativeInherited
Biological Process (BP)positive regulation of response to stimulus0.30140.7705Moderately InformativeInherited
Biological Process (BP)system process0.026750.09157Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.011230Moderately InformativeInherited
Biological Process (BP)regulation of localization0.024241Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.36410Moderately InformativeInherited
Biological Process (BP)regulation of catalytic activity0.09990Moderately InformativeInherited
Biological Process (BP)positive regulation of molecular function0.057210Moderately InformativeInherited
Biological Process (BP)organ development0.0000071390.7878Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.017670.0000004572Moderately InformativeInherited
Biological Process (BP)regulation of phosphate metabolic process10Moderately InformativeInherited
Biological Process (BP)multi-organism process0.0028150.5049Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.049131Moderately InformativeInherited
Biological Process (BP)response to organic substance0.16430.2684Moderately InformativeInherited
Biological Process (BP)signal transduction0.045090.0000009776Moderately InformativeInherited
Biological Process (BP)organelle organization0.10370.005538Moderately InformativeInherited
Biological Process (BP)regulation of nucleoside metabolic process0.000000000044190InformativeDirect
Biological Process (BP)regulation of purine nucleotide metabolic process0.00000000021710InformativeDirect
Biological Process (BP)positive regulation of hydrolase activity0.00000000035650InformativeDirect
Biological Process (BP)cytoskeleton organization0.000049880InformativeDirect
Biological Process (BP)positive regulation of cellular component organization0.00069280InformativeDirect
Biological Process (BP)actin filament-based process0.00077510InformativeDirect
Biological Process (BP)positive regulation of signal transduction0.45851InformativeInherited
Biological Process (BP)regulation of intracellular protein kinase cascade0.42181InformativeInherited
Biological Process (BP)regulation of cellular component movement0.0022580.8163InformativeInherited
Biological Process (BP)positive regulation of transport0.025561InformativeInherited
Biological Process (BP)regulation of defense response0.0000088970.3751InformativeInherited
Biological Process (BP)regulation of response to external stimulus0.074061InformativeInherited
Biological Process (BP)negative regulation of cell death0.042060.9976InformativeInherited
Biological Process (BP)negative regulation of transport0.0028980.02532InformativeInherited
Biological Process (BP)regulation of secretion0.041430.2212InformativeInherited
Biological Process (BP)regulation of immune response0.26651InformativeInherited
Biological Process (BP)negative regulation of immune system process0.00045680.005854InformativeInherited
Biological Process (BP)regulation of immune effector process0.00000046890.006649InformativeInherited
Biological Process (BP)regulation of cell activation0.00046510.6381InformativeInherited
Biological Process (BP)regulation of vesicle-mediated transport0.00070310.2457InformativeInherited
Biological Process (BP)sensory organ development0.000031021InformativeInherited
Biological Process (BP)embryonic organ development0.00019421InformativeInherited
Biological Process (BP)embryonic morphogenesis0.00073940.01059InformativeInherited
Biological Process (BP)organ morphogenesis0.0051140.000003724InformativeInherited
Biological Process (BP)regulation of cellular catabolic process0.0011560InformativeInherited
Biological Process (BP)response to bacterium0.000016960.2606InformativeInherited
Biological Process (BP)response to lipid0.000025151InformativeInherited
Biological Process (BP)negative regulation of response to stimulus0.048361InformativeInherited
Biological Process (BP)regulation of locomotion0.0018750.04066InformativeInherited
Biological Process (BP)intracellular signal transduction0.011390InformativeInherited
Biological Process (BP)positive regulation of GTPase activity0.000000000004990Highly InformativeDirect
Biological Process (BP)regulation of Rho protein signal transduction0.000000000007410Highly InformativeDirect
Biological Process (BP)negative regulation of immune effector process0.0000000014950.00000219Highly InformativeDirect
Biological Process (BP)small GTPase mediated signal transduction0.0000000064760Highly InformativeDirect
Biological Process (BP)regulation of protein kinase B signaling cascade0.0000000086160.00001207Highly InformativeDirect
Biological Process (BP)negative regulation of leukocyte activation0.000000012390.00003254Highly InformativeDirect
Biological Process (BP)regulation of exocytosis0.00000002820.00002589Highly InformativeDirect
Biological Process (BP)negative regulation of secretion0.000000038390.00002771Highly InformativeDirect
Biological Process (BP)negative regulation of response to external stimulus0.000000061980.0001958Highly InformativeDirect
Biological Process (BP)negative regulation of neuron death0.000000088450.000104Highly InformativeDirect
Biological Process (BP)response to lipopolysaccharide0.00000024480.0003651Highly InformativeDirect
Biological Process (BP)negative regulation of cellular component movement0.0001850.000854Highly InformativeDirect
Biological Process (BP)neuromuscular process0.0000000070770.08601Highly InformativeInherited
Biological Process (BP)regulation of endocytosis0.00020930.8083Highly InformativeInherited
Biological Process (BP)regulation of neuron apoptotic process0.00000032820.7148Highly InformativeInherited
Biological Process (BP)negative regulation of apoptotic process0.0000099431Highly InformativeInherited
Biological Process (BP)embryonic organ morphogenesis0.000000049161Highly InformativeInherited
Biological Process (BP)ear development0.017360.001047Highly InformativeInherited
Biological Process (BP)regulation of Ras GTPase activity0.01010Highly InformativeInherited
Molecular Function (MF)enzyme regulator activity0.0000000000030230Moderately InformativeDirect
Molecular Function (MF)GTPase regulator activity0.0000000010090InformativeDirect
Molecular Function (MF)enzyme activator activity0.00055821InformativeInherited
Molecular Function (MF)GTPase activator activity0.028751Highly InformativeInherited
Molecular Function (MF)small GTPase regulator activity0.042320.0000565Highly InformativeInherited
Cellular Component (CC)cytoplasmic part0.00045560.01411Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.22011Least InformativeInherited
Cellular Component (CC)vesicle0.0008390.0008849Moderately InformativeDirect
Cellular Component (CC)cell projection0.0011180Moderately InformativeInherited
Cellular Component (CC)cell leading edge0.0000023160InformativeDirect
Cellular Component (CC)endocytic vesicle0.00000092340.000007088Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 0.00000000008402 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.00000000000001778 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) localization 0.007299 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of signal transduction 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.0000004572 Moderately Informative Direct
Biological Process (BP) signal transduction 0.0000009776 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 0 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0 Moderately Informative Direct
Biological Process (BP) nervous system development 0.0000009992 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.0000002769 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.0000001987 Moderately Informative Direct
Biological Process (BP) immune system process 0.00003747 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.0009046 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.7705 Moderately Informative Inherited
Biological Process (BP) system process 0.09157 Moderately Informative Inherited
Biological Process (BP) organ development 0.7878 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.4118 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.2684 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.02346 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.02047 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.5049 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.005538 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.9163 Moderately Informative Inherited
Biological Process (BP) reproduction 0.2619 Moderately Informative Inherited
Biological Process (BP) regulation of nucleoside metabolic process 0 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0 Informative Direct
Biological Process (BP) cytoskeleton organization 0 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0 Informative Direct
Biological Process (BP) actin filament-based process 0 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0 Informative Direct
Biological Process (BP) organ morphogenesis 0.000003724 Informative Direct
Biological Process (BP) intracellular signal transduction 0 Informative Direct
Biological Process (BP) regulation of nervous system development 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) regulation of cell development 0 Informative Direct
Biological Process (BP) localization of cell 0 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0 Informative Direct
Biological Process (BP) apoptotic process 0 Informative Direct
Biological Process (BP) cell projection organization 0 Informative Direct
Biological Process (BP) cellular component movement 0.000000000001403 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.00000000002437 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.0000000000355 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0.0000000004076 Informative Direct
Biological Process (BP) regulation of organelle organization 0.000000001912 Informative Direct
Biological Process (BP) synaptic transmission 0.000000006497 Informative Direct
Biological Process (BP) pigment metabolic process 0.00000004473 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.000001244 Informative Direct
Biological Process (BP) secondary metabolic process 0.00006305 Informative Direct
Biological Process (BP) generation of neurons 0.0001763 Informative Direct
Biological Process (BP) biological adhesion 0.0002926 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0.0007753 Informative Direct
Biological Process (BP) negative regulation of developmental process 0.162 Informative Inherited
Biological Process (BP) growth 0.2314 Informative Inherited
Biological Process (BP) tube development 1 Informative Inherited
Biological Process (BP) response to organonitrogen compound 1 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 1 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 1 Informative Inherited
Biological Process (BP) epithelium development 0.3932 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.2611 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 1 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.8163 Informative Inherited
Biological Process (BP) organelle assembly 0.2838 Informative Inherited
Biological Process (BP) microtubule-based process 1 Informative Inherited
Biological Process (BP) positive regulation of transport 1 Informative Inherited
Biological Process (BP) regulation of defense response 0.3751 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 1 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) reproductive system development 1 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.3382 Informative Inherited
Biological Process (BP) positive regulation of gene expression 0.02185 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.03181 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.04273 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.06471 Informative Inherited
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 1 Informative Inherited
Biological Process (BP) regulation of growth 0.5721 Informative Inherited
Biological Process (BP) negative regulation of cell death 0.9976 Informative Inherited
Biological Process (BP) negative regulation of transport 0.02532 Informative Inherited
Biological Process (BP) regulation of secretion 0.2212 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.005854 Informative Inherited
Biological Process (BP) regulation of immune effector process 0.006649 Informative Inherited
Biological Process (BP) regulation of cell activation 0.6381 Informative Inherited
Biological Process (BP) regulation of vesicle-mediated transport 0.2457 Informative Inherited
Biological Process (BP) sensory organ development 1 Informative Inherited
Biological Process (BP) embryonic organ development 1 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) immune response 0.0193 Informative Inherited
Biological Process (BP) defense response 0.05845 Informative Inherited
Biological Process (BP) immune effector process 0.009251 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) regulation of cytokine production 1 Informative Inherited
Biological Process (BP) response to bacterium 0.2606 Informative Inherited
Biological Process (BP) response to lipid 1 Informative Inherited
Biological Process (BP) regulation of ion transport 0.7918 Informative Inherited
Biological Process (BP) sexual reproduction 0.4234 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.9806 Informative Inherited
Biological Process (BP) regulation of locomotion 0.04066 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) leukocyte activation 0.01047 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.3182 Informative Inherited
Biological Process (BP) multi-multicellular organism process 0.125 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.007058 Informative Inherited
Biological Process (BP) central nervous system development 0.472 Informative Inherited
Biological Process (BP) cellular membrane organization 0.65 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.01059 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.7788 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.9423 Informative Inherited
Biological Process (BP) cell cycle process 1 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.004026 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.4346 Informative Inherited
Biological Process (BP) positive regulation of GTPase activity 0 Highly Informative Direct
Biological Process (BP) regulation of Rho protein signal transduction 0 Highly Informative Direct
Biological Process (BP) negative regulation of immune effector process 0.00000219 Highly Informative Direct
Biological Process (BP) small GTPase mediated signal transduction 0 Highly Informative Direct
Biological Process (BP) regulation of protein kinase B signaling cascade 0.00001207 Highly Informative Direct
Biological Process (BP) negative regulation of leukocyte activation 0.00003254 Highly Informative Direct
Biological Process (BP) regulation of exocytosis 0.00002589 Highly Informative Direct
Biological Process (BP) negative regulation of secretion 0.00002771 Highly Informative Direct
Biological Process (BP) negative regulation of response to external stimulus 0.0001958 Highly Informative Direct
Biological Process (BP) negative regulation of neuron death 0.000104 Highly Informative Direct
Biological Process (BP) response to lipopolysaccharide 0.0003651 Highly Informative Direct
Biological Process (BP) negative regulation of cellular component movement 0.000854 Highly Informative Direct
Biological Process (BP) regulation of Ras GTPase activity 0 Highly Informative Direct
Biological Process (BP) positive regulation of programmed cell death 0 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 0 Highly Informative Direct
Biological Process (BP) chemotaxis 0.000000000000005594 Highly Informative Direct
Biological Process (BP) phagocytosis 0.0000000000004365 Highly Informative Direct
Biological Process (BP) post-embryonic organ development 0.00000000001115 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 0.00000000004562 Highly Informative Direct
Biological Process (BP) T cell differentiation 0.0000000001192 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.00000000129 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.000000002684 Highly Informative Direct
Biological Process (BP) limb morphogenesis 0.000000005009 Highly Informative Direct
Biological Process (BP) leukocyte migration 0.00000001258 Highly Informative Direct
Biological Process (BP) cell projection assembly 0.00000002027 Highly Informative Direct
Biological Process (BP) positive regulation of organelle organization 0.000000564 Highly Informative Direct
Biological Process (BP) post-embryonic development 0.000001945 Highly Informative Direct
Biological Process (BP) regulation of striated muscle cell differentiation 0.0001909 Highly Informative Direct
Biological Process (BP) regulation of neuron projection development 0.0005945 Highly Informative Direct
Biological Process (BP) regulation of protein complex disassembly 0.1184 Highly Informative Inherited
Biological Process (BP) cell growth 0.02423 Highly Informative Inherited
Biological Process (BP) developmental growth 0.3801 Highly Informative Inherited
Biological Process (BP) renal system development 1 Highly Informative Inherited
Biological Process (BP) cellular response to peptide 0.009876 Highly Informative Inherited
Biological Process (BP) actin filament-based movement 0.662 Highly Informative Inherited
Biological Process (BP) regulation of actin cytoskeleton organization 0.001107 Highly Informative Inherited
Biological Process (BP) spindle organization 0.02165 Highly Informative Inherited
Biological Process (BP) neuromuscular process 0.08601 Highly Informative Inherited
Biological Process (BP) regulation of endocytosis 0.8083 Highly Informative Inherited
Biological Process (BP) regulation of striated muscle tissue development 0.001064 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.05508 Highly Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.09319 Highly Informative Inherited
Biological Process (BP) cell fate commitment 1 Highly Informative Inherited
Biological Process (BP) positive regulation of transcription, DNA-dependent 0.009432 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.001984 Highly Informative Inherited
Biological Process (BP) regulation of cell size 0.1195 Highly Informative Inherited
Biological Process (BP) regulation of cell adhesion 0.00542 Highly Informative Inherited
Biological Process (BP) regulation of neuron apoptotic process 0.7148 Highly Informative Inherited
Biological Process (BP) negative regulation of apoptotic process 1 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 1 Highly Informative Inherited
Biological Process (BP) ear development 0.001047 Highly Informative Inherited
Biological Process (BP) respiratory system development 0.3882 Highly Informative Inherited
Biological Process (BP) innate immune response 0.009157 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.01739 Highly Informative Inherited
Biological Process (BP) maintenance of location 0.0904 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane transport 0.3454 Highly Informative Inherited
Biological Process (BP) regulation of protein complex assembly 0.09741 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.2127 Highly Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 0.555 Highly Informative Inherited
Biological Process (BP) regulation of transporter activity 0.9796 Highly Informative Inherited
Biological Process (BP) neuron projection development 0.5647 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.4136 Highly Informative Inherited
Biological Process (BP) cell part morphogenesis 1 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 0.6458 Highly Informative Inherited
Biological Process (BP) meiosis 0.1556 Highly Informative Inherited
Biological Process (BP) regulation of microtubule polymerization or depolymerization 0.3726 Highly Informative Inherited
Biological Process (BP) negative regulation of cytoskeleton organization 1 Highly Informative Inherited
Biological Process (BP) cell division 0.007252 Highly Informative Inherited
Biological Process (BP) actomyosin structure organization 1 Highly Informative Inherited
Molecular Function (MF) binding 0.000000000000004577 Least Informative Direct
Molecular Function (MF) enzyme regulator activity 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.0000003332 Moderately Informative Direct
Molecular Function (MF) GTPase regulator activity 0 Informative Direct
Molecular Function (MF) lipid binding 0.0000000000003438 Informative Direct
Molecular Function (MF) enzyme binding 0.000000002924 Informative Direct
Molecular Function (MF) receptor binding 0.1823 Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0.1337 Informative Inherited
Molecular Function (MF) enzyme activator activity 1 Informative Inherited
Molecular Function (MF) small GTPase regulator activity 0.0000565 Highly Informative Direct
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0 Highly Informative Direct
Molecular Function (MF) Ras GTPase binding 1 Highly Informative Inherited
Molecular Function (MF) tubulin binding 0.003824 Highly Informative Inherited
Molecular Function (MF) phosphatidylinositol binding 0.05745 Highly Informative Inherited
Molecular Function (MF) GTPase activator activity 1 Highly Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.0005673 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.01411 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) membrane 0.05314 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) vesicle 0.0008849 Moderately Informative Direct
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) cytosol 0.0000002922 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.00001873 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.09735 Moderately Informative Inherited
Cellular Component (CC) cell leading edge 0 Informative Direct
Cellular Component (CC) cell cortex 0 Informative Direct
Cellular Component (CC) cell junction 0.00000303 Informative Direct
Cellular Component (CC) contractile fiber part 0.00009886 Informative Direct
Cellular Component (CC) synapse part 0.000206 Informative Direct
Cellular Component (CC) neuron projection 1 Informative Inherited
Cellular Component (CC) actin cytoskeleton 0.2768 Informative Inherited
Cellular Component (CC) endocytic vesicle 0.000007088 Highly Informative Direct
Cellular Component (CC) extrinsic to plasma membrane 0.00000000000001188 Highly Informative Direct
Cellular Component (CC) cell division site part 0.0000000000001148 Highly Informative Direct
Cellular Component (CC) growth cone 0.0001601 Highly Informative Direct
Cellular Component (CC) cell body 0.0001859 Highly Informative Direct
Cellular Component (CC) dendrite 0.008197 Highly Informative Inherited
Cellular Component (CC) cortical cytoskeleton 0.294 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype0.2633Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.377Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.5311Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.618Least InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.07142Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.07206Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.1104Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukopoiesis0.4597Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.6785Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.8951Moderately InformativeInherited
Mammalian Phenotype (MP)decreased leukocyte cell number0.04187InformativeInherited
Mammalian Phenotype (MP)abnormal uvea morphology0.04679InformativeInherited
Mammalian Phenotype (MP)abnormal anterior eye segment morphology0.1708InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation0.2861InformativeInherited
Mammalian Phenotype (MP)increased hematopoietic cell number0.4446InformativeInherited
Mammalian Phenotype (MP)abnormal lymphocyte cell number0.6653InformativeInherited
Mammalian Phenotype (MP)abnormal vascular endothelial cell development0.005778Highly InformativeInherited
Mammalian Phenotype (MP)abnormal immature B cell morphology0.1806Highly InformativeInherited
Mammalian Phenotype (MP)increased lymphocyte cell number0.8336Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)pharyngeal pumping variant0.0003694Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation0.000000008261Moderately InformativeDirect
Biological processCell cycle0.00000429Moderately InformativeDirect
Biological processNeurogenesis0.00000000004053InformativeDirect
Biological processEndocytosis0.000003254InformativeDirect
Biological processInnate immunity0.00002745InformativeDirect
Biological processSeptation0.0007557Highly InformativeDirect
Cellular componentCytoplasm0.000000001364Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentGolgi apparatus0.00002635Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.000158Moderately InformativeDirect
Cellular componentEndosome0.0006402Moderately InformativeDirect
Cellular componentMicrotubule0.0003359InformativeDirect
Cellular componentSynapse1InformativeInherited
Cellular componentSynaptosome0.0001048Highly InformativeDirect
Coding sequence diversityAlternative splicing0.00000003764Least InformativeDirect
DiseaseProto-oncogene0.000000000003612Moderately InformativeDirect
DomainRepeat0.00000000001598Least InformativeDirect
DomainCoiled coil3.091e-16Moderately InformativeDirect
DomainZinc-finger0.000001307Moderately InformativeDirect
DomainSH3 domain0InformativeDirect
DomainSH2 domain0.00000000005642InformativeDirect
DomainImmunoglobulin domain0.0009566InformativeDirect
Molecular functionZinc0.00004256Least InformativeDirect
Molecular functionCalmodulin-binding0.000000549InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationDevelopmental protein0.000002945Moderately InformativeDirect
Post-translational modificationKinase0.08192Moderately InformativeInherited
Post-translational modificationGTPase activation0InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor0InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0.00000005802InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationMyristate0.0001097InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR000219 SSF48065 Protein matches
Abstract

The Rho family GTPases Rho, Rac and CDC42 regulate a diverse array of cellular processes. Like all members of the Ras superfamily, the Rho proteins cycle between active GTP-bound and inactive GDP-bound conformational states. Activation of Rho proteins through release of bound GDP and subsequent binding of GTP, is catalyzed by guanine nucleotide exchange factors (GEFs) in the Dbl family. The proteins encoded by members of the Dbl family share a common domain, presented in this entry, of about 200 residues (designated the Dbl homology or DH domain) that has been shown to encode a GEF activity specific for a number of Rho family members. In addition, all family members possess a second, shared domain designated the pleckstrin homology (PH) domain . Trio and its homolog UNC-73 are unique within the Dbl family insomuch as they encode two distinct DH/PH domain modules. The PH domain is invariably located immediately C-terminal to the DH domain and this invariant topography suggests a functional interdependence between these two structural modules. Biochemical data have established the role of the conserved DH domain in Rho GTPase interaction and activation, and the role of the tandem PH domain in intracellular targeting and/or regulation of DH domain function. The DH domain of Dbl has been shown to mediate oligomerization that is mostly homophilic in nature. In addition to the tandem DH/PH domains Dbl family GEFs contain diverse structural motifs like serine/threonine kinase, RBD, PDZ, RGS, IQ, REM, Cdc25 RasGEF, CH, SH2, SH3, EF, spectrin or Ig.

The DH domain is composed of three structurally conserved regions separated by more variable regions. It does not share significant sequence homology with other subtypes of small G-protein GEF motifs such as the Cdc25 domain and the Sec7 domain, which specifically interact with Ras and ARF family small GTPases, respectively, nor with other Rho protein interactive motifs, indicating that the Dbl family proteins are evolutionarily unique. The DH domain is composed of 11 alpha helices that are folded into a flattened, elongated alpha-helix bundle in which two of the three conserved regions, conserved region 1 (CR1) and conserved region 3 (CR3), are exposed near the centre of one surface. CR1 and CR3, together with a part of alpha-6 and the DH/PH junction site, constitute the Rho GTPase interacting pocket.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 10 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a DBL homology domain (DH-domain) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 10 hidden Markov models representing the DBL homology domain (DH-domain) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]