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Transcription factor STAT-4 N-domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Transcription factor STAT-4 N-domain [ 48091]
Superfamily:   Transcription factor STAT-4 N-domain [ 48092]
Families:   Transcription factor STAT-4 N-domain [ 48093]


Superfamily statistics
Genomes (125) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 639 0 1
Proteins 639 0 1


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.09213Least InformativeInherited
Disease Ontology (DO)lower respiratory tract disease0.00008071Moderately InformativeDirect
Disease Ontology (DO)urinary system disease0.001681Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.00267Moderately InformativeInherited
Disease Ontology (DO)hematologic cancer0.0171Moderately InformativeInherited
Disease Ontology (DO)disease by infectious agent0.01793Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.7675Moderately InformativeInherited
Disease Ontology (DO)inflammatory bowel disease0.000001177InformativeDirect
Disease Ontology (DO)head and neck carcinoma0.0000191InformativeDirect
Disease Ontology (DO)asthma0.0001194InformativeDirect
Disease Ontology (DO)nephritis0.0003477InformativeDirect
Disease Ontology (DO)myeloid leukemia0.1327InformativeInherited
Disease Ontology (DO)viral infectious disease0.2685InformativeInherited
Disease Ontology (DO)mumps0.000000003951Highly InformativeDirect
Disease Ontology (DO)colitis0.0000001594Highly InformativeDirect
Disease Ontology (DO)Sjogren's syndrome0.00001043Highly InformativeDirect
Disease Ontology (DO)chronic leukemia0.00001099Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of immune system physiology0.07367Moderately InformativeInherited
Phenotypic Abnormality (PA)Autoimmunity0.0001346InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)hematopoietic system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect
Mammalian Phenotype (MP)abnormal homeostasis0.02171Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.07396Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body region phenotype0.1054Least InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal leukocyte physiology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal blood cell morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal protein level0.00001727Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal gland morphology0.0006693Moderately InformativeDirect
Mammalian Phenotype (MP)liver/biliary system phenotype0.0008942Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cell death0.001835Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.005092Moderately InformativeInherited
Mammalian Phenotype (MP)neoplasm0.02367Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.03102Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.03707Moderately InformativeInherited
Mammalian Phenotype (MP)reproductive system phenotype0.03748Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal postnatal growth/weight/body size0.04051Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.04576Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal body composition0.1733Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal myeloid cell morphology0.4353Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.7146Moderately InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to infection0.8286Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin level0.000000004273InformativeDirect
Mammalian Phenotype (MP)abnormal circulating cytokine level0.000000008403InformativeDirect
Mammalian Phenotype (MP)abnormal interleukin secretion0.0000001332InformativeDirect
Mammalian Phenotype (MP)abnormal mammary gland morphology0.0000003336InformativeDirect
Mammalian Phenotype (MP)abnormal B lymphocyte antigen presentation0.0000003825InformativeDirect
Mammalian Phenotype (MP)abnormal liver physiology0.000003439InformativeDirect
Mammalian Phenotype (MP)abnormal adaptive thermogenesis0.00006359InformativeDirect
Mammalian Phenotype (MP)increased apoptosis0.0001343InformativeDirect
Mammalian Phenotype (MP)increased susceptibility to infection0.0002428InformativeDirect
Mammalian Phenotype (MP)abnormal circulating leptin level0.0003295InformativeDirect
Mammalian Phenotype (MP)decreased cell proliferation0.0003423InformativeDirect
Mammalian Phenotype (MP)altered tumor pathology0.0008796InformativeDirect
Mammalian Phenotype (MP)increased body weight0.001126InformativeInherited
Mammalian Phenotype (MP)abnormal female reproductive gland morphology0.00115InformativeInherited
Mammalian Phenotype (MP)abnormal internal female genitalia morphology0.002384InformativeInherited
Mammalian Phenotype (MP)abnormal adipose tissue amount0.00939InformativeInherited
Mammalian Phenotype (MP)abnormal gland physiology0.009863InformativeInherited
Mammalian Phenotype (MP)abnormal T cell differentiation0.01334InformativeInherited
Mammalian Phenotype (MP)abnormal consumption behavior0.04321InformativeInherited
Mammalian Phenotype (MP)abnormal glucose homeostasis0.05128InformativeInherited
Mammalian Phenotype (MP)abnormal pancreas morphology0.0515InformativeInherited
Mammalian Phenotype (MP)abnormal interferon level0.05161InformativeInherited
Mammalian Phenotype (MP)abnormal triglyceride level0.1353InformativeInherited
Mammalian Phenotype (MP)abnormal T cell physiology0.145InformativeInherited
Mammalian Phenotype (MP)abnormal circulating lipid level0.1656InformativeInherited
Mammalian Phenotype (MP)abnormal interferon secretion0.2328InformativeInherited
Mammalian Phenotype (MP)abnormal effector T cell morphology0.2465InformativeInherited
Mammalian Phenotype (MP)abnormal natural killer cell mediated cytotoxicity0.3234InformativeInherited
Mammalian Phenotype (MP)abnormal alpha-beta T cell morphology0.329InformativeInherited
Mammalian Phenotype (MP)abnormal erythroid lineage cell morphology0.3707InformativeInherited
Mammalian Phenotype (MP)abnormal T cell activation0.00000002748Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mammary gland epithelium physiology0.0000001539Highly InformativeDirect
Mammalian Phenotype (MP)abnormal CD4-positive, alpha beta T cell morphology0.0000001563Highly InformativeDirect
Mammalian Phenotype (MP)abnormal level of surface class II molecules0.0000001814Highly InformativeDirect
Mammalian Phenotype (MP)increased interferon-gamma secretion0.000001085Highly InformativeDirect
Mammalian Phenotype (MP)impaired adaptive thermogenesis0.000001603Highly InformativeDirect
Mammalian Phenotype (MP)increased percent body fat/body weight0.000005306Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating insulin-like growth factor I level0.00000597Highly InformativeDirect
Mammalian Phenotype (MP)decreased mean corpuscular hemoglobin0.000007519Highly InformativeDirect
Mammalian Phenotype (MP)obese0.00002115Highly InformativeDirect
Mammalian Phenotype (MP)abnormal corpus luteum morphology0.00003134Highly InformativeDirect
Mammalian Phenotype (MP)increased lean body mass0.00007887Highly InformativeDirect
Mammalian Phenotype (MP)increased total body fat amount0.0001044Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating triglyceride level0.0001349Highly InformativeDirect
Mammalian Phenotype (MP)abnormal endocrine pancreas secretion0.0001613Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pancreatic beta cell physiology0.0002345Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating insulin level0.0002868Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pancreatic islet morphology0.0004472Highly InformativeDirect
Mammalian Phenotype (MP)decreased lean body mass0.000521Highly InformativeDirect
Mammalian Phenotype (MP)abnormal fat pad morphology0.0006722Highly InformativeDirect
Mammalian Phenotype (MP)abnormal food intake0.002525Highly InformativeInherited
Mammalian Phenotype (MP)abnormal liver size0.0843Highly InformativeInherited

Document: MP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0Least InformativeDirect
Zebrafish Anatomy (ZA)portion of organism substance0Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect
Xenopus ANatomical entity (XAN)brain0Moderately InformativeDirect

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation0Moderately InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
DomainSH2 domain0InformativeDirect
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationDNA-binding0Moderately InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation0.00001608Moderately InformativeDirect
Post-translational modificationADP-ribosylation0.000000008322InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR013799 SSF48092 Protein matches
Abstract

This entry represents the N-terminal domain, which is responsible for protein interactions. This domain has a multi-helical structure that can be subdivided into two structural sub-domains.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Transcription factor STAT-4 N-domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Transcription factor STAT-4 N-domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]