SUPERFAMILY 1.75 HMM library and genome assignments server

Transcription factor STAT-4 N-domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Transcription factor STAT-4 N-domain [ 48091]
Superfamily:   Transcription factor STAT-4 N-domain [ 48092]
Families:   Transcription factor STAT-4 N-domain [ 48093]


Superfamily statistics
Genomes (120) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 629 955 1
Proteins 629 952 1


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process00Least InformativeDirect
Biological Process (BP)developmental process00Least InformativeDirect
Biological Process (BP)multicellular organismal process00Least InformativeDirect
Biological Process (BP)response to stimulus00Least InformativeDirect
Biological Process (BP)single-organism cellular process00.00000000000002963Least InformativeDirect
Biological Process (BP)regulation of metabolic process00.0000001825Least InformativeDirect
Biological Process (BP)signal transduction00Moderately InformativeDirect
Biological Process (BP)organ development00Moderately InformativeDirect
Biological Process (BP)immune system process00Moderately InformativeDirect
Biological Process (BP)regulation of macromolecule biosynthetic process00Moderately InformativeDirect
Biological Process (BP)regulation of developmental process00Moderately InformativeDirect
Biological Process (BP)cell differentiation00Moderately InformativeDirect
Biological Process (BP)regulation of nucleobase-containing compound metabolic process00Moderately InformativeDirect
Biological Process (BP)positive regulation of metabolic process00Moderately InformativeDirect
Biological Process (BP)regulation of gene expression00Moderately InformativeDirect
Biological Process (BP)regulation of cellular biosynthetic process00Moderately InformativeDirect
Biological Process (BP)positive regulation of cellular process00.000000000001621Moderately InformativeDirect
Biological Process (BP)regulation of multicellular organismal process00.000000000001672Moderately InformativeDirect
Biological Process (BP)negative regulation of cellular process00.00000104Moderately InformativeDirect
Biological Process (BP)tissue development00.001304Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis00.5226Moderately InformativeInherited
Biological Process (BP)positive regulation of nucleobase-containing compound metabolic process00InformativeDirect
Biological Process (BP)positive regulation of gene expression00InformativeDirect
Biological Process (BP)regulation of cell proliferation00InformativeDirect
Biological Process (BP)positive regulation of macromolecule biosynthetic process00.000000000000001938InformativeDirect
Biological Process (BP)positive regulation of cellular biosynthetic process00.00000000000003126InformativeDirect
Biological Process (BP)regulation of cell activation00.000000005344InformativeDirect
Biological Process (BP)regulation of transcription from RNA polymerase II promoter00.0000000126InformativeDirect
Biological Process (BP)gland development00.0000001261InformativeDirect
Biological Process (BP)hematopoietic or lymphoid organ development00.000002796InformativeDirect
Biological Process (BP)leukocyte activation00.0005466InformativeDirect
Biological Process (BP)epithelium development01InformativeInherited
Biological Process (BP)positive regulation of immune system process00.001032InformativeInherited
Biological Process (BP)regulation of immune effector process00.01382InformativeInherited
Biological Process (BP)positive regulation of transcription, DNA-dependent00.0000000000001083Highly InformativeDirect
Biological Process (BP)positive regulation of cell activation00.00000005687Highly InformativeDirect
Biological Process (BP)mammary gland epithelium development00.0000002813Highly InformativeDirect
Molecular Function (MF)binding00.0000004622Least InformativeDirect
Molecular Function (MF)nucleic acid binding00Moderately InformativeDirect
Molecular Function (MF)DNA binding00InformativeDirect
Molecular Function (MF)transcription regulatory region DNA binding00.0000000006593Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.00000000000002963 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.0000001825 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.000002975 Least Informative Direct
Biological Process (BP) biosynthetic process 0.0004021 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.0005946 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.002278 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.001212 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.0124 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 0.003325 Least Informative Inherited
Biological Process (BP) signal transduction 0 Moderately Informative Direct
Biological Process (BP) organ development 0 Moderately Informative Direct
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0 Moderately Informative Direct
Biological Process (BP) cell differentiation 0 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.000000000001621 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.000000000001672 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.00000104 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.000000000000003755 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0.00000000000001086 Moderately Informative Direct
Biological Process (BP) reproduction 0.00000000000003126 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.000000000005098 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0.00000000002413 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 0.00000000002891 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.000000005774 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 0.000000006578 Moderately Informative Direct
Biological Process (BP) gene expression 0.000000007132 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 0.0000000183 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.00000002511 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.0000002219 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0.0003106 Moderately Informative Direct
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.001304 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.009753 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.6961 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.7402 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.8039 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.5226 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.02755 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.8733 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.8957 Moderately Informative Inherited
Biological Process (BP) system process 0.02411 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.2971 Moderately Informative Inherited
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 0 Informative Direct
Biological Process (BP) positive regulation of gene expression 0 Informative Direct
Biological Process (BP) regulation of cell proliferation 0 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.000000000000001938 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0.00000000000003126 Informative Direct
Biological Process (BP) regulation of cell activation 0.000000005344 Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.0000000126 Informative Direct
Biological Process (BP) gland development 0.0000001261 Informative Direct
Biological Process (BP) hematopoietic or lymphoid organ development 0.000002796 Informative Direct
Biological Process (BP) leukocyte activation 0.0005466 Informative Direct
Biological Process (BP) regulation of peptidase activity 0 Informative Direct
Biological Process (BP) blood circulation 0 Informative Direct
Biological Process (BP) response to nutrient levels 0 Informative Direct
Biological Process (BP) transcription, DNA-dependent 0 Informative Direct
Biological Process (BP) response to cytokine stimulus 0 Informative Direct
Biological Process (BP) negative regulation of developmental process 0 Informative Direct
Biological Process (BP) apoptotic process 0.000000000000003755 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0.0000000000004674 Informative Direct
Biological Process (BP) regulation of defense response 0.0000000000009132 Informative Direct
Biological Process (BP) regulation of mitotic cell cycle 0.00000000001231 Informative Direct
Biological Process (BP) intracellular signal transduction 0.00000000003905 Informative Direct
Biological Process (BP) regulation of growth 0.0000000006653 Informative Direct
Biological Process (BP) response to hormone stimulus 0.00000000472 Informative Direct
Biological Process (BP) phosphorylation 0.000000008634 Informative Direct
Biological Process (BP) lipid localization 0.00000002158 Informative Direct
Biological Process (BP) response to organonitrogen compound 0.00000002726 Informative Direct
Biological Process (BP) cellular response to nitrogen compound 0.00000005222 Informative Direct
Biological Process (BP) regulation of body fluid levels 0.00000008407 Informative Direct
Biological Process (BP) defense response 0.0000002961 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.0000003951 Informative Direct
Biological Process (BP) generation of neurons 0.0000006156 Informative Direct
Biological Process (BP) multi-multicellular organism process 0.000000678 Informative Direct
Biological Process (BP) immune response 0.000002107 Informative Direct
Biological Process (BP) response to bacterium 0.000004703 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 0.00001193 Informative Direct
Biological Process (BP) multicellular organismal reproductive process 0.0002984 Informative Direct
Biological Process (BP) protein localization to organelle 0.0004734 Informative Direct
Biological Process (BP) regulation of cell development 1 Informative Inherited
Biological Process (BP) regulation of nervous system development 1 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.04575 Informative Inherited
Biological Process (BP) regulation of locomotion 0.1112 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.001819 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.22 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.251 Informative Inherited
Biological Process (BP) reproductive system development 0.03426 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 1 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.00203 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.001961 Informative Inherited
Biological Process (BP) central nervous system development 1 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.001032 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.0597 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.0749 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.001091 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.01072 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.02361 Informative Inherited
Biological Process (BP) single organism reproductive process 0.002046 Informative Inherited
Biological Process (BP) regulation of immune response 0.1057 Informative Inherited
Biological Process (BP) regulation of immune effector process 0.01382 Informative Inherited
Biological Process (BP) positive regulation of protein metabolic process 0.8876 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.005004 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.002485 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.004719 Informative Inherited
Biological Process (BP) negative regulation of cell death 0.01741 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.002036 Informative Inherited
Biological Process (BP) response to lipid 0.9935 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 0.7928 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.01755 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.2353 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.002989 Informative Inherited
Biological Process (BP) protein transport 0.00443 Informative Inherited
Biological Process (BP) organ morphogenesis 0.004982 Informative Inherited
Biological Process (BP) sensory organ development 0.002243 Informative Inherited
Biological Process (BP) positive regulation of transcription, DNA-dependent 0.0000000000001083 Highly Informative Direct
Biological Process (BP) positive regulation of cell activation 0.00000005687 Highly Informative Direct
Biological Process (BP) mammary gland epithelium development 0.0000002813 Highly Informative Direct
Biological Process (BP) female pregnancy 0 Highly Informative Direct
Biological Process (BP) cytokine-mediated signaling pathway 0 Highly Informative Direct
Biological Process (BP) regulation of epithelial cell differentiation 0 Highly Informative Direct
Biological Process (BP) regulation of mononuclear cell proliferation 0 Highly Informative Direct
Biological Process (BP) lactation 0 Highly Informative Direct
Biological Process (BP) positive regulation of endopeptidase activity 0 Highly Informative Direct
Biological Process (BP) ovulation cycle process 0 Highly Informative Direct
Biological Process (BP) negative regulation of cell differentiation 0 Highly Informative Direct
Biological Process (BP) regulation of multicellular organism growth 0 Highly Informative Direct
Biological Process (BP) carbohydrate homeostasis 0 Highly Informative Direct
Biological Process (BP) mesenchyme development 0.00000000000006719 Highly Informative Direct
Biological Process (BP) regulation of smooth muscle cell proliferation 0.0000000000002869 Highly Informative Direct
Biological Process (BP) response to peptide hormone stimulus 0.00000000000033 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.00000000006264 Highly Informative Direct
Biological Process (BP) positive regulation of leukocyte mediated cytotoxicity 0.0000000001233 Highly Informative Direct
Biological Process (BP) leukocyte homeostasis 0.0000000004357 Highly Informative Direct
Biological Process (BP) regulation of cytokine biosynthetic process 0.0000000007357 Highly Informative Direct
Biological Process (BP) positive regulation of response to external stimulus 0.000000001797 Highly Informative Direct
Biological Process (BP) cellular response to peptide 0.000000003503 Highly Informative Direct
Biological Process (BP) regulation of myeloid cell differentiation 0.00000002278 Highly Informative Direct
Biological Process (BP) renal system development 0.00000002835 Highly Informative Direct
Biological Process (BP) gonad development 0.00000005189 Highly Informative Direct
Biological Process (BP) response to purine-containing compound 0.00000005784 Highly Informative Direct
Biological Process (BP) positive regulation of defense response 0.00000006272 Highly Informative Direct
Biological Process (BP) negative regulation of carbohydrate metabolic process 0.0000001295 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.000000131 Highly Informative Direct
Biological Process (BP) eye morphogenesis 0.0000001672 Highly Informative Direct
Biological Process (BP) stem cell proliferation 0.0000002083 Highly Informative Direct
Biological Process (BP) regulation of cysteine-type endopeptidase activity involved in apoptotic process 0.0000003053 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 0.0000003224 Highly Informative Direct
Biological Process (BP) protein targeting to nucleus 0.0000006289 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 0.000001044 Highly Informative Direct
Biological Process (BP) regulation of angiogenesis 0.000001151 Highly Informative Direct
Biological Process (BP) protein localization to nucleus 0.00000231 Highly Informative Direct
Biological Process (BP) regulation of leukocyte differentiation 0.000003475 Highly Informative Direct
Biological Process (BP) negative regulation of cellular catabolic process 0.000003865 Highly Informative Direct
Biological Process (BP) positive regulation of growth 0.00002255 Highly Informative Direct
Biological Process (BP) development of primary female sexual characteristics 0.00004498 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0.00005891 Highly Informative Direct
Biological Process (BP) nuclear import 0.00007449 Highly Informative Direct
Biological Process (BP) innate immune response 0.0001072 Highly Informative Direct
Biological Process (BP) protein import 0.0003508 Highly Informative Direct
Biological Process (BP) positive regulation of leukocyte proliferation 0.0009493 Highly Informative Direct
Biological Process (BP) negative regulation of cellular component movement 0.003544 Highly Informative Inherited
Biological Process (BP) negative regulation of locomotion 0.002887 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 1 Highly Informative Inherited
Biological Process (BP) glial cell differentiation 0.01835 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 0.387 Highly Informative Inherited
Biological Process (BP) positive regulation of lymphocyte mediated immunity 0.3743 Highly Informative Inherited
Biological Process (BP) regulation of innate immune response 0.09129 Highly Informative Inherited
Biological Process (BP) hormone-mediated signaling pathway 0.00128 Highly Informative Inherited
Biological Process (BP) negative regulation of apoptotic process 0.8037 Highly Informative Inherited
Biological Process (BP) response to lipopolysaccharide 0.04924 Highly Informative Inherited
Biological Process (BP) stem cell development 0.01749 Highly Informative Inherited
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.002036 Highly Informative Inherited
Molecular Function (MF) binding 0.0000004622 Least Informative Direct
Molecular Function (MF) nucleic acid binding 0 Moderately Informative Direct
Molecular Function (MF) DNA binding 0 Informative Direct
Molecular Function (MF) nucleic acid binding transcription factor activity 0 Informative Direct
Molecular Function (MF) protein dimerization activity 0.00000000002777 Informative Direct
Molecular Function (MF) enzyme binding 0.0000002518 Informative Direct
Molecular Function (MF) molecular transducer activity 0.0000002982 Informative Direct
Molecular Function (MF) receptor binding 0.04295 Informative Inherited
Molecular Function (MF) transcription regulatory region DNA binding 0.0000000006593 Highly Informative Direct
Molecular Function (MF) sequence-specific DNA binding transcription factor activity 0 Highly Informative Direct
Molecular Function (MF) protein phosphatase binding 0.0000000002335 Highly Informative Direct
Molecular Function (MF) cytokine receptor binding 0.00008469 Highly Informative Direct
Molecular Function (MF) kinase binding 0.03484 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.79 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.000000005775 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.3295 Moderately Informative Inherited
Cellular Component (CC) cell projection 0.5456 Moderately Informative Inherited
Cellular Component (CC) neuron projection 0.001309 Informative Inherited
Cellular Component (CC) dendrite 0.000007165 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.04628Least InformativeInherited
Disease Ontology (DO)organ system cancer0.08676Least InformativeInherited
Disease Ontology (DO)obstructive lung disease0.00001501Moderately InformativeDirect
Disease Ontology (DO)urinary system disease0.001737Moderately InformativeInherited
Disease Ontology (DO)hematologic cancer0.01773Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.7545Moderately InformativeInherited
Disease Ontology (DO)inflammatory bowel disease0.000001373InformativeDirect
Disease Ontology (DO)glomerulonephritis0.0001088InformativeDirect
Disease Ontology (DO)myeloid leukemia0.135InformativeInherited
Disease Ontology (DO)viral infectious disease0.2717InformativeInherited
Disease Ontology (DO)mumps0.000000005262Highly InformativeDirect
Disease Ontology (DO)colitis0.0000001874Highly InformativeDirect
Disease Ontology (DO)Sjogren's syndrome0.0000115Highly InformativeDirect
Disease Ontology (DO)chronic leukemia0.00001167Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details) Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)hematopoietic system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect
Mammalian Phenotype (MP)abnormal homeostasis0.01516Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.07681Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body phenotype0.1089Least InformativeInherited
Mammalian Phenotype (MP)abnormal immune cell physiology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal adaptive immunity0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cell-mediated immunity0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal leukopoiesis0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal blood cell physiology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal protein level0.000009695Moderately InformativeDirect
Mammalian Phenotype (MP)tumorigenesis0.0003461Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal gland morphology0.0005665Moderately InformativeDirect
Mammalian Phenotype (MP)liver/biliary system phenotype0.0008538Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cell death0.002536Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.01363Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.03166Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.03587Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.0368Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.03793Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal postnatal growth/weight/body size0.03837Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.2576Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.3101Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.3381Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal T cell morphology0InformativeDirect
Mammalian Phenotype (MP)abnormal interleukin level0.000000007287InformativeDirect
Mammalian Phenotype (MP)abnormal circulating cytokine level0.00000001245InformativeDirect
Mammalian Phenotype (MP)abnormal interleukin secretion0.0000002346InformativeDirect
Mammalian Phenotype (MP)abnormal hepatobiliary system physiology0.000007661InformativeDirect
Mammalian Phenotype (MP)increased apoptosis0.0001714InformativeDirect
Mammalian Phenotype (MP)abnormal circulating leptin level0.0004218InformativeDirect
Mammalian Phenotype (MP)increased susceptibility to infection0.0004962InformativeDirect
Mammalian Phenotype (MP)abnormal antigen presentation0.0009244InformativeDirect
Mammalian Phenotype (MP)abnormal respiration0.0009703InformativeDirect
Mammalian Phenotype (MP)abnormal thymus morphology0.001876InformativeInherited
Mammalian Phenotype (MP)abnormal female genitalia morphology0.002697InformativeInherited
Mammalian Phenotype (MP)abnormal adipose tissue amount0.008275InformativeInherited
Mammalian Phenotype (MP)abnormal mammary gland morphology0.008622InformativeInherited
Mammalian Phenotype (MP)abnormal cell proliferation0.02044InformativeInherited
Mammalian Phenotype (MP)abnormal interferon level0.05451InformativeInherited
Mammalian Phenotype (MP)abnormal pancreas morphology0.05562InformativeInherited
Mammalian Phenotype (MP)abnormal consumption behavior0.06273InformativeInherited
Mammalian Phenotype (MP)abnormal triglyceride level0.1501InformativeInherited
Mammalian Phenotype (MP)abnormal total tissue mass0.1582InformativeInherited
Mammalian Phenotype (MP)abnormal interferon secretion0.2359InformativeInherited
Mammalian Phenotype (MP)abnormal sex gland morphology0.3039InformativeInherited
Mammalian Phenotype (MP)abnormal lymph organ size0.4415InformativeInherited
Mammalian Phenotype (MP)abnormal lymphocyte cell number0.4539InformativeInherited
Mammalian Phenotype (MP)abnormal B cell physiology0.6504InformativeInherited
Mammalian Phenotype (MP)abnormal CD4-positive, alpha beta T cell morphology0.0000001778Highly InformativeDirect
Mammalian Phenotype (MP)abnormal level of surface class II molecules0.0000003052Highly InformativeDirect
Mammalian Phenotype (MP)increased interferon-gamma secretion0.00000197Highly InformativeDirect
Mammalian Phenotype (MP)impaired adaptive thermogenesis0.000002369Highly InformativeDirect
Mammalian Phenotype (MP)impaired natural killer cell mediated cytotoxicity0.00000517Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating insulin-like growth factor I level0.000006962Highly InformativeDirect
Mammalian Phenotype (MP)abnormal alpha-beta T cell number0.00001157Highly InformativeDirect
Mammalian Phenotype (MP)obese0.00002394Highly InformativeDirect
Mammalian Phenotype (MP)abnormal corpus luteum morphology0.00003776Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating leptin level0.00005598Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating triglyceride level0.0001204Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mammary gland development0.0001566Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating insulin level0.0003126Highly InformativeDirect
Mammalian Phenotype (MP)decreased tumor incidence0.0003536Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pancreatic islet morphology0.00049Highly InformativeDirect
Mammalian Phenotype (MP)impaired glucose tolerance0.0007009Highly InformativeDirect
Mammalian Phenotype (MP)abnormal food intake0.002972Highly InformativeInherited
Mammalian Phenotype (MP)abnormal body fat mass0.003275Highly InformativeInherited
Mammalian Phenotype (MP)abnormal gland physiology0.0114Highly InformativeInherited
Mammalian Phenotype (MP)abnormal thymus size0.04692Highly InformativeInherited
Mammalian Phenotype (MP)abnormal liver size0.08199Highly InformativeInherited

Document: MP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation0Moderately InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
DomainSH2 domain0InformativeDirect
Molecular functionDNA-binding0Least InformativeDirect
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation0.00001418Moderately InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR013799 SSF48092 Protein matches
Abstract

This entry represents the N-terminal domain, which is responsible for protein interactions. This domain has a multi-helical structure that can be subdivided into two structural sub-domains.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Transcription factor STAT-4 N-domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Transcription factor STAT-4 N-domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · UniProtKB KeyWords (KW) · Internal database links ]