SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.


Transcription factor STAT-4 N-domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Transcription factor STAT-4 N-domain [ 48091]
Superfamily:   Transcription factor STAT-4 N-domain [ 48092]
Families:   Transcription factor STAT-4 N-domain [ 48093]


Superfamily statistics
Genomes (120) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 628 955 1
Proteins 628 952 1


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) cellular nitrogen compound metabolic process 0.423 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.002499 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.7691 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.08147 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.7619 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.265 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) signaling 0 Moderately Informative Direct
Biological Process (BP) cell communication 0 Moderately Informative Direct
Biological Process (BP) system development 0 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.00000000000375 Moderately Informative Direct
Biological Process (BP) cellular developmental process 0.0000000005438 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.000000001407 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.00000001609 Moderately Informative Direct
Biological Process (BP) regulation of biosynthetic process 0.00000002792 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.00000005843 Moderately Informative Direct
Biological Process (BP) regulation of cellular metabolic process 0.0000000642 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0.0000000899 Moderately Informative Direct
Biological Process (BP) reproduction 0.000001896 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.000007117 Moderately Informative Direct
Biological Process (BP) regulation of nitrogen compound metabolic process 0.00003726 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 0.0001224 Moderately Informative Direct
Biological Process (BP) single-organism transport 0.0002425 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.0005774 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.00329 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.02014 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.3264 Moderately Informative Inherited
Biological Process (BP) response to stress 0.2197 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.1278 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.2552 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.08273 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing compound biosynthetic process 0.003577 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.05386 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.08767 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.002501 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.02073 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.7483 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.427 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.06144 Moderately Informative Inherited
Biological Process (BP) gene expression 0.1037 Moderately Informative Inherited
Biological Process (BP) regulation of cell proliferation 0 Informative Direct
Biological Process (BP) regulation of transcription, DNA-templated 0 Informative Direct
Biological Process (BP) response to cytokine 0 Informative Direct
Biological Process (BP) regulation of apoptotic process 0 Informative Direct
Biological Process (BP) intracellular signal transduction 0.0000000000000208 Informative Direct
Biological Process (BP) regulation of cell differentiation 0.0000000000002726 Informative Direct
Biological Process (BP) regulation of hydrolase activity 0.0000000000007624 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.0000000000662 Informative Direct
Biological Process (BP) cellular response to hormone stimulus 0.00000000009482 Informative Direct
Biological Process (BP) immune response 0.0000000001836 Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.000000005261 Informative Direct
Biological Process (BP) response to nitrogen compound 0.000000007924 Informative Direct
Biological Process (BP) cell death 0.00000001386 Informative Direct
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0.00000004332 Informative Direct
Biological Process (BP) positive regulation of gene expression 0.0000001468 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0.000000256 Informative Direct
Biological Process (BP) cell surface receptor signaling pathway 0.000001486 Informative Direct
Biological Process (BP) regulation of defense response 0.000006561 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.00002127 Informative Direct
Biological Process (BP) nucleocytoplasmic transport 0.00002309 Informative Direct
Biological Process (BP) regulation of proteolysis 0.0000234 Informative Direct
Biological Process (BP) generation of neurons 0.00005384 Informative Direct
Biological Process (BP) transcription, DNA-templated 0.00007674 Informative Direct
Biological Process (BP) lipid localization 0.0001012 Informative Direct
Biological Process (BP) protein targeting 0.0001331 Informative Direct
Biological Process (BP) behavior 0.0001625 Informative Direct
Biological Process (BP) positive regulation of cell death 0.0001871 Informative Direct
Biological Process (BP) negative regulation of signaling 0.0002052 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.0002055 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.0002821 Informative Direct
Biological Process (BP) protein localization to organelle 0.0004839 Informative Direct
Biological Process (BP) system process 0.0008159 Informative Direct
Biological Process (BP) regulation of growth 0.0009662 Informative Direct
Biological Process (BP) response to organic cyclic compound 0.02887 Informative Inherited
Biological Process (BP) central nervous system development 1 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.08374 Informative Inherited
Biological Process (BP) regulation of cell cycle 0.01096 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.003819 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.01868 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.007918 Informative Inherited
Biological Process (BP) response to oxidative stress 0.3659 Informative Inherited
Biological Process (BP) response to inorganic substance 1 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.3051 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.01655 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.2799 Informative Inherited
Biological Process (BP) single organism reproductive process 0.4329 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.0187 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.2875 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.06154 Informative Inherited
Biological Process (BP) secretion 0.004801 Informative Inherited
Biological Process (BP) multi-organism reproductive process 0.001123 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.6085 Informative Inherited
Biological Process (BP) embryo development 1 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 0.2427 Informative Inherited
Biological Process (BP) single-organism intracellular transport 0.03751 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.4124 Informative Inherited
Biological Process (BP) reproductive system development 0.3573 Informative Inherited
Biological Process (BP) response to nutrient levels 0 Highly Informative Direct
Biological Process (BP) hemopoiesis 0 Highly Informative Direct
Biological Process (BP) cytokine-mediated signaling pathway 0 Highly Informative Direct
Biological Process (BP) apoptotic process 0.000000000000001902 Highly Informative Direct
Biological Process (BP) lymphocyte activation 0.0000000000000208 Highly Informative Direct
Biological Process (BP) cell proliferation 0.00000000000003395 Highly Informative Direct
Biological Process (BP) response to organophosphorus 0.00000000000006292 Highly Informative Direct
Biological Process (BP) regulation of smooth muscle cell proliferation 0.00000000000008976 Highly Informative Direct
Biological Process (BP) ovulation cycle process 0.000000000004542 Highly Informative Direct
Biological Process (BP) response to purine-containing compound 0.000000000009106 Highly Informative Direct
Biological Process (BP) positive regulation of proteolysis 0.00000000001484 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.00000000004985 Highly Informative Direct
Biological Process (BP) innate immune response 0.0000000001256 Highly Informative Direct
Biological Process (BP) positive regulation of mitotic cell cycle 0.0000000008741 Highly Informative Direct
Biological Process (BP) response to peptide hormone 0.0000000009868 Highly Informative Direct
Biological Process (BP) positive regulation of lymphocyte activation 0.000000001578 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular signal transduction 0.000000007612 Highly Informative Direct
Biological Process (BP) sex differentiation 0.00000002492 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-templated 0.0000001236 Highly Informative Direct
Biological Process (BP) cellular response to organonitrogen compound 0.0000002421 Highly Informative Direct
Biological Process (BP) response to hydrogen peroxide 0.000000531 Highly Informative Direct
Biological Process (BP) sensory organ morphogenesis 0.0000005893 Highly Informative Direct
Biological Process (BP) protein targeting to nucleus 0.0000007325 Highly Informative Direct
Biological Process (BP) single-organism nuclear import 0.000000794 Highly Informative Direct
Biological Process (BP) negative regulation of homeostatic process 0.0000009878 Highly Informative Direct
Biological Process (BP) gastrulation 0.00000393 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 0.000004726 Highly Informative Direct
Biological Process (BP) regulation of inflammatory response 0.00002737 Highly Informative Direct
Biological Process (BP) multicellular organismal homeostasis 0.00004344 Highly Informative Direct
Biological Process (BP) positive regulation of response to external stimulus 0.0001477 Highly Informative Direct
Biological Process (BP) multi-multicellular organism process 0.0001776 Highly Informative Direct
Biological Process (BP) hormone-mediated signaling pathway 0.0001957 Highly Informative Direct
Biological Process (BP) protein import 0.0003688 Highly Informative Direct
Biological Process (BP) positive regulation of cell adhesion 0.02697 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 1 Highly Informative Inherited
Biological Process (BP) gliogenesis 0.001248 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.003116 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 0.04599 Highly Informative Inherited
Biological Process (BP) positive regulation of apoptotic process 0.02257 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.01234 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 0.09432 Highly Informative Inherited
Biological Process (BP) regulation of lymphocyte proliferation 0.02034 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.03488 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.0123 Highly Informative Inherited
Biological Process (BP) positive regulation of leukocyte proliferation 0.2221 Highly Informative Inherited
Biological Process (BP) regulation of cysteine-type endopeptidase activity 0.1113 Highly Informative Inherited
Biological Process (BP) regulation of epithelial cell proliferation 0.005114 Highly Informative Inherited
Molecular Function (MF) binding 0.00000007097 Least Informative Direct
Molecular Function (MF) nucleic acid binding 0 Moderately Informative Direct
Molecular Function (MF) protein binding 0.5457 Moderately Informative Inherited
Molecular Function (MF) DNA binding 0 Informative Direct
Molecular Function (MF) transcription factor activity, sequence-specific DNA binding 0 Informative Direct
Molecular Function (MF) enzyme binding 0.0000000000003926 Informative Direct
Molecular Function (MF) protein dimerization activity 0.00000001355 Informative Direct
Molecular Function (MF) receptor binding 0.02297 Informative Inherited
Molecular Function (MF) macromolecular complex binding 0.001242 Informative Inherited
Molecular Function (MF) protein phosphatase binding 0.00000000002096 Highly Informative Direct
Molecular Function (MF) chromatin binding 0.000000001887 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0.00000004845 Highly Informative Direct
Molecular Function (MF) cytokine receptor binding 0.00008974 Highly Informative Direct
Molecular Function (MF) G-protein coupled receptor binding 0.000124 Highly Informative Direct
Molecular Function (MF) transcription regulatory region DNA binding 0.0004424 Highly Informative Direct
Molecular Function (MF) kinase binding 0.001384 Highly Informative Inherited
Molecular Function (MF) sequence-specific DNA binding 0.2301 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.3264 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.4358 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.000008723 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.02194 Moderately Informative Inherited
Cellular Component (CC) cell projection 0.1521 Moderately Informative Inherited
Cellular Component (CC) neuron projection 0.0003211 Informative Direct
Cellular Component (CC) nucleolus 0.00000001952 Highly Informative Direct
Cellular Component (CC) dendrite 0.000001091 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.09117Least InformativeInherited
Disease Ontology (DO)organ system cancer0.09172Least InformativeInherited
Disease Ontology (DO)lower respiratory tract disease0.00007882Moderately InformativeDirect
Disease Ontology (DO)urinary system disease0.001664Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.002601Moderately InformativeInherited
Disease Ontology (DO)hematologic cancer0.01691Moderately InformativeInherited
Disease Ontology (DO)disease by infectious agent0.01724Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.7634Moderately InformativeInherited
Disease Ontology (DO)inflammatory bowel disease0.000001079InformativeDirect
Disease Ontology (DO)head and neck carcinoma0.00001876InformativeDirect
Disease Ontology (DO)asthma0.0001183InformativeDirect
Disease Ontology (DO)nephritis0.0003394InformativeDirect
Disease Ontology (DO)myeloid leukemia0.1327InformativeInherited
Disease Ontology (DO)viral infectious disease0.2667InformativeInherited
Disease Ontology (DO)mumps0.000000004049Highly InformativeDirect
Disease Ontology (DO)colitis0.0000001545Highly InformativeDirect
Disease Ontology (DO)Sjogren's syndrome0.00001014Highly InformativeDirect
Disease Ontology (DO)chronic leukemia0.00001111Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the immune system0.04485Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the face0.4039Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the oral cavity0.1318Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of oral mucosa0.0004558InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)hematopoietic system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect
Mammalian Phenotype (MP)abnormal homeostasis0.01868Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.07846Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body region phenotype0.1066Least InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal leukocyte physiology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal blood cell morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal protein level0.00001204Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal gland morphology0.0006656Moderately InformativeDirect
Mammalian Phenotype (MP)liver/biliary system phenotype0.0009544Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cell death0.001996Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.004935Moderately InformativeInherited
Mammalian Phenotype (MP)neoplasm0.02479Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal body size0.026Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.03013Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.03639Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.04415Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.3376Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.7148Moderately InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to infection0.8286Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin level0.000000004824InformativeDirect
Mammalian Phenotype (MP)abnormal circulating cytokine level0.000000009454InformativeDirect
Mammalian Phenotype (MP)abnormal interleukin secretion0.0000001466InformativeDirect
Mammalian Phenotype (MP)abnormal mammary gland morphology0.0000003591InformativeDirect
Mammalian Phenotype (MP)abnormal B lymphocyte antigen presentation0.0000004059InformativeDirect
Mammalian Phenotype (MP)abnormal liver physiology0.000003739InformativeDirect
Mammalian Phenotype (MP)abnormal adaptive thermogenesis0.00007346InformativeDirect
Mammalian Phenotype (MP)increased apoptosis0.0001466InformativeDirect
Mammalian Phenotype (MP)increased susceptibility to infection0.0002604InformativeDirect
Mammalian Phenotype (MP)abnormal circulating leptin level0.0003417InformativeDirect
Mammalian Phenotype (MP)decreased cell proliferation0.0003646InformativeDirect
Mammalian Phenotype (MP)altered tumor pathology0.0009191InformativeDirect
Mammalian Phenotype (MP)increased body weight0.001165InformativeInherited
Mammalian Phenotype (MP)abnormal female reproductive gland morphology0.001217InformativeInherited
Mammalian Phenotype (MP)abnormal circulating triglyceride level0.00127InformativeInherited
Mammalian Phenotype (MP)abnormal internal female genitalia morphology0.002349InformativeInherited
Mammalian Phenotype (MP)abnormal adipose tissue amount0.008497InformativeInherited
Mammalian Phenotype (MP)abnormal gland physiology0.01034InformativeInherited
Mammalian Phenotype (MP)abnormal glucose homeostasis0.04107InformativeInherited
Mammalian Phenotype (MP)abnormal consumption behavior0.0478InformativeInherited
Mammalian Phenotype (MP)abnormal interferon level0.05121InformativeInherited
Mammalian Phenotype (MP)abnormal pancreas morphology0.05226InformativeInherited
Mammalian Phenotype (MP)abnormal triglyceride level0.1354InformativeInherited
Mammalian Phenotype (MP)abnormal T cell physiology0.147InformativeInherited
Mammalian Phenotype (MP)abnormal interferon secretion0.2329InformativeInherited
Mammalian Phenotype (MP)abnormal effector T cell morphology0.2518InformativeInherited
Mammalian Phenotype (MP)abnormal natural killer cell mediated cytotoxicity0.3168InformativeInherited
Mammalian Phenotype (MP)abnormal alpha-beta T cell morphology0.3384InformativeInherited
Mammalian Phenotype (MP)abnormal T cell activation0.00000003082Highly InformativeDirect
Mammalian Phenotype (MP)abnormal CD4-positive, alpha beta T cell morphology0.0000001426Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mammary gland epithelium physiology0.0000001622Highly InformativeDirect
Mammalian Phenotype (MP)abnormal level of surface class II molecules0.0000001921Highly InformativeDirect
Mammalian Phenotype (MP)increased interferon-gamma secretion0.00000117Highly InformativeDirect
Mammalian Phenotype (MP)impaired adaptive thermogenesis0.000001694Highly InformativeDirect
Mammalian Phenotype (MP)increased percent body fat/body weight0.000005585Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating insulin-like growth factor I level0.000005926Highly InformativeDirect
Mammalian Phenotype (MP)obese0.00002239Highly InformativeDirect
Mammalian Phenotype (MP)abnormal corpus luteum morphology0.00003301Highly InformativeDirect
Mammalian Phenotype (MP)increased total body fat amount0.0000873Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating triglyceride level0.0001341Highly InformativeDirect
Mammalian Phenotype (MP)abnormal endocrine pancreas secretion0.0001708Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pancreatic beta cell physiology0.0002421Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating insulin level0.0002927Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pancreatic islet morphology0.0004742Highly InformativeDirect
Mammalian Phenotype (MP)abnormal fat pad morphology0.0007004Highly InformativeDirect
Mammalian Phenotype (MP)abnormal food intake0.002601Highly InformativeInherited
Mammalian Phenotype (MP)abnormal liver size0.08216Highly InformativeInherited

Document: MP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0Moderately InformativeDirect
Zebrafish Anatomy (ZA)portion of organism substance0Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)brain0Moderately InformativeDirect

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation0Moderately InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
DomainSH2 domain0InformativeDirect
Molecular functionDNA-binding0Least InformativeDirect
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation0.00008744Moderately InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR013799 SSF48092 Protein matches
Abstract

This entry represents the N-terminal domain, which is responsible for protein interactions. This domain has a multi-helical structure that can be subdivided into two structural sub-domains.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Transcription factor STAT-4 N-domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Transcription factor STAT-4 N-domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]