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Transcription factor STAT-4 N-domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Transcription factor STAT-4 N-domain [ 48091]
Superfamily:   Transcription factor STAT-4 N-domain [ 48092]
Families:   Transcription factor STAT-4 N-domain [ 48093]


Superfamily statistics
Genomes (125) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 639 1,426 1
Proteins 639 1,416 1


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 0.7729 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.7602 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.2655 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.08352 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 0.4246 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.2414 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) reproduction 0.000003725 Moderately Informative Direct
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) defense response 0.0000000001424 Moderately Informative Direct
Biological Process (BP) cell communication 0 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0.00000000002131 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0.00000001457 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.00000004913 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 0.000000001778 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.00000002803 Moderately Informative Direct
Biological Process (BP) cell differentiation 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 0.0004493 Moderately Informative Direct
Biological Process (BP) single organism signaling 0 Moderately Informative Direct
Biological Process (BP) single-organism transport 0.000446 Moderately Informative Direct
Biological Process (BP) animal organ development 0 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.0000000005724 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.0000000000004904 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.00003742 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.0006249 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 0.00006828 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.06679 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.9387 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.09452 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.03532 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.05499 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.0017 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.01055 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.2163 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.01507 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.5107 Moderately Informative Inherited
Biological Process (BP) nitrogen compound transport 0.2368 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.3325 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.005476 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.002095 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.01867 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.01489 Moderately Informative Inherited
Biological Process (BP) gene expression 0.109 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.06297 Moderately Informative Inherited
Biological Process (BP) tissue development 0.01673 Moderately Informative Inherited
Biological Process (BP) cell activation 0.000000000002075 Informative Direct
Biological Process (BP) positive regulation of immune system process 0.0000004689 Informative Direct
Biological Process (BP) system process 0.00003331 Informative Direct
Biological Process (BP) transcription, DNA-templated 0.00007866 Informative Direct
Biological Process (BP) immune response 0.00000000000006022 Informative Direct
Biological Process (BP) cell surface receptor signaling pathway 0.00002031 Informative Direct
Biological Process (BP) behavior 0.0002392 Informative Direct
Biological Process (BP) cell death 0.0000000003276 Informative Direct
Biological Process (BP) response to extracellular stimulus 0.000001278 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.000000000001522 Informative Direct
Biological Process (BP) positive regulation of gene expression 0.0000000381 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.00006337 Informative Direct
Biological Process (BP) lipid localization 0.00009779 Informative Direct
Biological Process (BP) negative regulation of signaling 0.00004809 Informative Direct
Biological Process (BP) hemopoiesis 0 Informative Direct
Biological Process (BP) regulation of proteolysis 0.00001423 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0.00000006193 Informative Direct
Biological Process (BP) regulation of defense response 0.000008776 Informative Direct
Biological Process (BP) cellular response to hormone stimulus 0.0000007765 Informative Direct
Biological Process (BP) protein localization to organelle 0.0005377 Informative Direct
Biological Process (BP) intracellular signal transduction 0.00000000000001079 Informative Direct
Biological Process (BP) regulation of cell proliferation 0 Informative Direct
Biological Process (BP) regulation of apoptotic process 0 Informative Direct
Biological Process (BP) multi-organism reproductive process 0.0007037 Informative Direct
Biological Process (BP) regulation of cell differentiation 0 Informative Direct
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 0.0000000002978 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.00007667 Informative Direct
Biological Process (BP) generation of neurons 0.000025 Informative Direct
Biological Process (BP) positive regulation of developmental process 0.000005728 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0.00000627 Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.00000001169 Informative Direct
Biological Process (BP) regulation of hydrolase activity 0.00000000000007302 Informative Direct
Biological Process (BP) response to nitrogen compound 0.00000001676 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.000004912 Informative Direct
Biological Process (BP) positive regulation of cellular protein metabolic process 0.1801 Informative Inherited
Biological Process (BP) single-organism cellular localization 0.03391 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.003992 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.05702 Informative Inherited
Biological Process (BP) response to wounding 0.609 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.3173 Informative Inherited
Biological Process (BP) central nervous system development 1 Informative Inherited
Biological Process (BP) regulation of cell cycle 0.01688 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.6554 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.405 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.04459 Informative Inherited
Biological Process (BP) response to oxidative stress 0.364 Informative Inherited
Biological Process (BP) locomotion 0.04936 Informative Inherited
Biological Process (BP) embryo development 1 Informative Inherited
Biological Process (BP) localization of cell 0.0578 Informative Inherited
Biological Process (BP) regulation of growth 0.00154 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.5498 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.02339 Informative Inherited
Biological Process (BP) protein transport 0.005825 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.03441 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.01578 Informative Inherited
Biological Process (BP) regulation of nervous system development 1 Informative Inherited
Biological Process (BP) reproductive system development 0.3817 Informative Inherited
Biological Process (BP) single organism reproductive process 0.4939 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.4167 Informative Inherited
Biological Process (BP) cell development 1 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.8565 Informative Inherited
Biological Process (BP) movement of cell or subcellular component 0.2221 Informative Inherited
Biological Process (BP) intracellular transport 0.1395 Informative Inherited
Biological Process (BP) growth 0.0488 Informative Inherited
Biological Process (BP) immune effector process 1 Informative Inherited
Biological Process (BP) kidney development 0.000000000004407 Highly Informative Direct
Biological Process (BP) leukocyte differentiation 0.0000000003432 Highly Informative Direct
Biological Process (BP) apoptotic process 0 Highly Informative Direct
Biological Process (BP) gastrulation 0.0000003484 Highly Informative Direct
Biological Process (BP) sex differentiation 0.00000003037 Highly Informative Direct
Biological Process (BP) cell proliferation 0.000000000000007296 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 0.000002628 Highly Informative Direct
Biological Process (BP) regulation of cell size 0.00001387 Highly Informative Direct
Biological Process (BP) response to purine-containing compound 0.00000000000004411 Highly Informative Direct
Biological Process (BP) protein import 0.0002093 Highly Informative Direct
Biological Process (BP) cytokine-mediated signaling pathway 0 Highly Informative Direct
Biological Process (BP) ovulation cycle process 0.000000000005764 Highly Informative Direct
Biological Process (BP) response to nutrient levels 0 Highly Informative Direct
Biological Process (BP) positive regulation of response to external stimulus 0.0001848 Highly Informative Direct
Biological Process (BP) negative regulation of homeostatic process 0.000002064 Highly Informative Direct
Biological Process (BP) positive regulation of homeostatic process 0.000000001135 Highly Informative Direct
Biological Process (BP) carbohydrate homeostasis 0.00001289 Highly Informative Direct
Biological Process (BP) protein localization to nucleus 0.000002218 Highly Informative Direct
Biological Process (BP) wound healing 0.0002856 Highly Informative Direct
Biological Process (BP) response to hydrogen peroxide 0.00000002282 Highly Informative Direct
Biological Process (BP) response to peptide hormone 0 Highly Informative Direct
Biological Process (BP) multi-multicellular organism process 0.0002327 Highly Informative Direct
Biological Process (BP) innate immune response 0.000000002863 Highly Informative Direct
Biological Process (BP) positive regulation of proteolysis 0.00000000000171 Highly Informative Direct
Biological Process (BP) positive regulation of mitotic cell cycle 0.000000002424 Highly Informative Direct
Biological Process (BP) lymphocyte activation 0 Highly Informative Direct
Biological Process (BP) response to organophosphorus 0 Highly Informative Direct
Biological Process (BP) regulation of smooth muscle cell proliferation 0.000000000000003734 Highly Informative Direct
Biological Process (BP) multicellular organismal homeostasis 0.00007862 Highly Informative Direct
Biological Process (BP) maintenance of location 0.0000005233 Highly Informative Direct
Biological Process (BP) positive regulation of lymphocyte activation 0.00000000177 Highly Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0 Highly Informative Direct
Biological Process (BP) cellular response to organonitrogen compound 0.00000002367 Highly Informative Direct
Biological Process (BP) sensory organ morphogenesis 0.000000251 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular signal transduction 0.00000000117 Highly Informative Direct
Biological Process (BP) single-organism nuclear import 0.0000006942 Highly Informative Direct
Biological Process (BP) regulation of hemopoiesis 0.000000000009846 Highly Informative Direct
Biological Process (BP) positive regulation of cell adhesion 0.02777 Highly Informative Inherited
Biological Process (BP) response to growth factor 1 Highly Informative Inherited
Biological Process (BP) neuron development 1 Highly Informative Inherited
Biological Process (BP) camera-type eye development 1 Highly Informative Inherited
Biological Process (BP) epithelial cell differentiation 0.6322 Highly Informative Inherited
Biological Process (BP) gliogenesis 0.003222 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.002766 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.1111 Highly Informative Inherited
Biological Process (BP) regulation of cysteine-type endopeptidase activity 0.08526 Highly Informative Inherited
Biological Process (BP) positive regulation of apoptotic process 0.01402 Highly Informative Inherited
Biological Process (BP) regeneration 0.006363 Highly Informative Inherited
Biological Process (BP) regulation of lymphocyte proliferation 0.01866 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 0.09513 Highly Informative Inherited
Biological Process (BP) positive regulation of leukocyte proliferation 0.2936 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.04312 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.04006 Highly Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 0.002028 Highly Informative Inherited
Biological Process (BP) positive regulation of cell development 1 Highly Informative Inherited
Biological Process (BP) positive regulation of nervous system development 0.7367 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.08345 Highly Informative Inherited
Biological Process (BP) plasma membrane bounded cell projection organization 0.04774 Highly Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 1 Highly Informative Inherited
Biological Process (BP) developmental growth involved in morphogenesis 0.002832 Highly Informative Inherited
Biological Process (BP) regulation of epithelial cell proliferation 0.003515 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.9069 Highly Informative Inherited
Molecular Function (MF) binding 0.0000007589 Least Informative Direct
Molecular Function (MF) nucleic acid binding 0 Moderately Informative Direct
Molecular Function (MF) DNA binding 0 Informative Direct
Molecular Function (MF) transcription factor activity, sequence-specific DNA binding 0 Informative Direct
Molecular Function (MF) enzyme binding 0.0000000000004529 Informative Direct
Molecular Function (MF) protein dimerization activity 0.0000000399 Informative Direct
Molecular Function (MF) receptor binding 0.006643 Informative Inherited
Molecular Function (MF) G-protein coupled receptor binding 0.00002112 Highly Informative Direct
Molecular Function (MF) chromatin binding 0.0000007024 Highly Informative Direct
Molecular Function (MF) cytokine receptor binding 0.00001996 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0.000000006415 Highly Informative Direct
Molecular Function (MF) protein phosphatase binding 0.00000000001994 Highly Informative Direct
Molecular Function (MF) transcription regulatory region DNA binding 0.0002696 Highly Informative Direct
Molecular Function (MF) kinase binding 0.001191 Highly Informative Inherited
Molecular Function (MF) double-stranded DNA binding 1 Highly Informative Inherited
Molecular Function (MF) sequence-specific DNA binding 0.3843 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.586 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.3336 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.0001485 Moderately Informative Direct
Cellular Component (CC) cell projection 0.09798 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.08602 Moderately Informative Inherited
Cellular Component (CC) neuron projection 0.0002198 Informative Direct
Cellular Component (CC) dendrite 0.0000002276 Highly Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation0Moderately InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentNucleus0Least InformativeDirect
DomainSH2 domain0InformativeDirect
Post-translational modificationDNA-binding0Moderately InformativeDirect
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation0.0004545Moderately InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR013799 SSF48092 Protein matches
Abstract

This entry represents the N-terminal domain, which is responsible for protein interactions. This domain has a multi-helical structure that can be subdivided into two structural sub-domains.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Transcription factor STAT-4 N-domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Transcription factor STAT-4 N-domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]