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Transcription factor STAT-4 N-domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Transcription factor STAT-4 N-domain [ 48091]
Superfamily:   Transcription factor STAT-4 N-domain [ 48092]
Families:   Transcription factor STAT-4 N-domain [ 48093]


Superfamily statistics
Genomes (122) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 631 955 1
Proteins 631 952 1


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) biosynthetic process 0.7197 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.7354 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.2348 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 0.3841 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.2704 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.06892 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.9983 Least Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0 Moderately Informative Direct
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) cell communication 0 Moderately Informative Direct
Biological Process (BP) single organism signaling 0 Moderately Informative Direct
Biological Process (BP) system development 0 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0 Moderately Informative Direct
Biological Process (BP) cellular developmental process 0.0000000000001856 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.0000000000008928 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 0.000000004734 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.000000005215 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0.00000002645 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.00000003517 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.00000004093 Moderately Informative Direct
Biological Process (BP) reproduction 0.000002361 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.00002007 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 0.0001297 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 0.0002083 Moderately Informative Direct
Biological Process (BP) single-organism transport 0.00032 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.0006256 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0.0181 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.8772 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.5477 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.1107 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.002203 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.01307 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.03112 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.1306 Moderately Informative Inherited
Biological Process (BP) nitrogen compound transport 0.2668 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.0012 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.2369 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.01828 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.3078 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.004565 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.01642 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.04703 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.05317 Moderately Informative Inherited
Biological Process (BP) gene expression 0.09282 Moderately Informative Inherited
Biological Process (BP) regulation of cell differentiation 0 Informative Direct
Biological Process (BP) regulation of apoptotic process 0 Informative Direct
Biological Process (BP) regulation of transcription, DNA-templated 0 Informative Direct
Biological Process (BP) regulation of cell proliferation 0 Informative Direct
Biological Process (BP) response to cytokine 0 Informative Direct
Biological Process (BP) intracellular signal transduction 0.00000000000003137 Informative Direct
Biological Process (BP) immune response 0.0000000000001623 Informative Direct
Biological Process (BP) regulation of hydrolase activity 0.0000000000005928 Informative Direct
Biological Process (BP) cell activation 0.000000000001199 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.000000000009321 Informative Direct
Biological Process (BP) cellular response to hormone stimulus 0.00000000008592 Informative Direct
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 0.0000000008018 Informative Direct
Biological Process (BP) cell death 0.0000000017 Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.0000000159 Informative Direct
Biological Process (BP) positive regulation of gene expression 0.0000000243 Informative Direct
Biological Process (BP) response to nitrogen compound 0.00000004203 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0.00000005131 Informative Direct
Biological Process (BP) cell surface receptor signaling pathway 0.000001819 Informative Direct
Biological Process (BP) response to extracellular stimulus 0.00000313 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0.000006156 Informative Direct
Biological Process (BP) positive regulation of developmental process 0.00000685 Informative Direct
Biological Process (BP) regulation of defense response 0.000007761 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.00001805 Informative Direct
Biological Process (BP) regulation of proteolysis 0.00001927 Informative Direct
Biological Process (BP) generation of neurons 0.00004798 Informative Direct
Biological Process (BP) transcription, DNA-templated 0.00006635 Informative Direct
Biological Process (BP) lipid localization 0.00008367 Informative Direct
Biological Process (BP) negative regulation of signaling 0.0001395 Informative Direct
Biological Process (BP) system process 0.0001605 Informative Direct
Biological Process (BP) behavior 0.0001629 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.0001803 Informative Direct
Biological Process (BP) positive regulation of cell death 0.000233 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.0002707 Informative Direct
Biological Process (BP) protein localization to organelle 0.0004841 Informative Direct
Biological Process (BP) multi-organism reproductive process 0.0006437 Informative Direct
Biological Process (BP) regulation of growth 0.0008569 Informative Direct
Biological Process (BP) regulation of intracellular signal transduction 0.07902 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.07311 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.02831 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.2779 Informative Inherited
Biological Process (BP) tissue development 0.03419 Informative Inherited
Biological Process (BP) central nervous system development 1 Informative Inherited
Biological Process (BP) sensory organ development 0.00591 Informative Inherited
Biological Process (BP) regulation of cell cycle 0.01306 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 0.36 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.6386 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.3702 Informative Inherited
Biological Process (BP) response to oxidative stress 0.4863 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.4911 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.02335 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.06614 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.06359 Informative Inherited
Biological Process (BP) single organism reproductive process 0.4523 Informative Inherited
Biological Process (BP) embryo development 1 Informative Inherited
Biological Process (BP) intracellular protein transport 0.001531 Informative Inherited
Biological Process (BP) single-organism intracellular transport 0.03113 Informative Inherited
Biological Process (BP) immune effector process 1 Informative Inherited
Biological Process (BP) reproductive system development 0.3898 Informative Inherited
Biological Process (BP) positive regulation of proteolysis 0 Highly Informative Direct
Biological Process (BP) apoptotic process 0 Highly Informative Direct
Biological Process (BP) cytokine-mediated signaling pathway 0 Highly Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0 Highly Informative Direct
Biological Process (BP) lymphocyte activation 0 Highly Informative Direct
Biological Process (BP) response to nutrient levels 0 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular signal transduction 0.000000000000001945 Highly Informative Direct
Biological Process (BP) cell proliferation 0.00000000000003469 Highly Informative Direct
Biological Process (BP) response to organophosphorus 0.00000000000005932 Highly Informative Direct
Biological Process (BP) regulation of smooth muscle cell proliferation 0.00000000000008674 Highly Informative Direct
Biological Process (BP) response to purine-containing compound 0.000000000003127 Highly Informative Direct
Biological Process (BP) ovulation cycle process 0.000000000004972 Highly Informative Direct
Biological Process (BP) kidney development 0.00000000003044 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.00000000003797 Highly Informative Direct
Biological Process (BP) leukocyte differentiation 0.0000000003077 Highly Informative Direct
Biological Process (BP) response to peptide hormone 0.0000000005682 Highly Informative Direct
Biological Process (BP) positive regulation of homeostatic process 0.0000000005705 Highly Informative Direct
Biological Process (BP) positive regulation of lymphocyte activation 0.000000001302 Highly Informative Direct
Biological Process (BP) innate immune response 0.00000000907 Highly Informative Direct
Biological Process (BP) sex differentiation 0.0000000229 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-templated 0.00000002716 Highly Informative Direct
Biological Process (BP) cellular response to organonitrogen compound 0.0000003202 Highly Informative Direct
Biological Process (BP) response to hydrogen peroxide 0.0000004572 Highly Informative Direct
Biological Process (BP) maintenance of location 0.0000005438 Highly Informative Direct
Biological Process (BP) protein targeting to nucleus 0.0000005633 Highly Informative Direct
Biological Process (BP) sensory organ morphogenesis 0.0000009665 Highly Informative Direct
Biological Process (BP) negative regulation of homeostatic process 0.00000207 Highly Informative Direct
Biological Process (BP) gastrulation 0.000003181 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 0.000003826 Highly Informative Direct
Biological Process (BP) multicellular organismal homeostasis 0.00007596 Highly Informative Direct
Biological Process (BP) positive regulation of response to external stimulus 0.000194 Highly Informative Direct
Biological Process (BP) multi-multicellular organism process 0.0002123 Highly Informative Direct
Biological Process (BP) protein import 0.0002192 Highly Informative Direct
Biological Process (BP) hormone-mediated signaling pathway 0.0002762 Highly Informative Direct
Biological Process (BP) gliogenesis 0.001825 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 0.09381 Highly Informative Inherited
Biological Process (BP) regulation of lymphocyte proliferation 0.01818 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.003494 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 0.07889 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.1012 Highly Informative Inherited
Biological Process (BP) regulation of cysteine-type endopeptidase activity 0.1043 Highly Informative Inherited
Biological Process (BP) positive regulation of apoptotic process 0.02161 Highly Informative Inherited
Biological Process (BP) positive regulation of cell adhesion 0.02347 Highly Informative Inherited
Biological Process (BP) positive regulation of leukocyte proliferation 0.2225 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.03097 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.02827 Highly Informative Inherited
Biological Process (BP) regulation of epithelial cell proliferation 0.004652 Highly Informative Inherited
Molecular Function (MF) binding 0.0000001613 Least Informative Direct
Molecular Function (MF) nucleic acid binding 0 Moderately Informative Direct
Molecular Function (MF) DNA binding 0 Informative Direct
Molecular Function (MF) transcription factor activity, sequence-specific DNA binding 0 Informative Direct
Molecular Function (MF) enzyme binding 0.0000000000004164 Informative Direct
Molecular Function (MF) protein dimerization activity 0.00000002168 Informative Direct
Molecular Function (MF) receptor binding 0.02177 Informative Inherited
Molecular Function (MF) protein phosphatase binding 0.00000000001636 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0.000000003987 Highly Informative Direct
Molecular Function (MF) chromatin binding 0.0000007252 Highly Informative Direct
Molecular Function (MF) cytokine receptor binding 0.00009021 Highly Informative Direct
Molecular Function (MF) G-protein coupled receptor binding 0.0001329 Highly Informative Direct
Molecular Function (MF) transcription regulatory region DNA binding 0.0001545 Highly Informative Direct
Molecular Function (MF) kinase binding 0.001343 Highly Informative Inherited
Molecular Function (MF) sequence-specific DNA binding 0.3985 Highly Informative Inherited
Molecular Function (MF) double-stranded DNA binding 1 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.5839 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.2798 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.0002576 Moderately Informative Direct
Cellular Component (CC) cell projection 0.1265 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.08889 Moderately Informative Inherited
Cellular Component (CC) neuron projection 0.0006415 Informative Direct
Cellular Component (CC) dendrite 0.000001247 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.0918Least InformativeInherited
Disease Ontology (DO)lower respiratory tract disease0.00007859Moderately InformativeDirect
Disease Ontology (DO)urinary system disease0.001668Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.002611Moderately InformativeInherited
Disease Ontology (DO)hematologic cancer0.01681Moderately InformativeInherited
Disease Ontology (DO)disease by infectious agent0.01765Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.7643Moderately InformativeInherited
Disease Ontology (DO)inflammatory bowel disease0.000001101InformativeDirect
Disease Ontology (DO)head and neck carcinoma0.00001808InformativeDirect
Disease Ontology (DO)asthma0.0001164InformativeDirect
Disease Ontology (DO)nephritis0.000338InformativeDirect
Disease Ontology (DO)myeloid leukemia0.1327InformativeInherited
Disease Ontology (DO)viral infectious disease0.2676InformativeInherited
Disease Ontology (DO)mumps0.000000003933Highly InformativeDirect
Disease Ontology (DO)colitis0.0000001537Highly InformativeDirect
Disease Ontology (DO)Sjogren's syndrome0.00001039Highly InformativeDirect
Disease Ontology (DO)chronic leukemia0.00001126Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the immune system0.04521Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the face0.4059Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the oral cavity0.1319Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of oral mucosa0.0004874InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)hematopoietic system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect
Mammalian Phenotype (MP)abnormal homeostasis0.02185Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.07394Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body region phenotype0.1058Least InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal leukocyte physiology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal blood cell morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal protein level0.00001763Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal gland morphology0.0006737Moderately InformativeDirect
Mammalian Phenotype (MP)liver/biliary system phenotype0.0008956Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cell death0.00184Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.005141Moderately InformativeInherited
Mammalian Phenotype (MP)neoplasm0.02361Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.03105Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.03731Moderately InformativeInherited
Mammalian Phenotype (MP)reproductive system phenotype0.03753Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal postnatal growth/weight/body size0.04071Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.04577Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal body composition0.1729Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal myeloid cell morphology0.4344Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.7164Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin level0.00000000436InformativeDirect
Mammalian Phenotype (MP)abnormal circulating cytokine level0.000000008709InformativeDirect
Mammalian Phenotype (MP)abnormal interleukin secretion0.0000001361InformativeDirect
Mammalian Phenotype (MP)abnormal mammary gland morphology0.00000034InformativeDirect
Mammalian Phenotype (MP)abnormal B lymphocyte antigen presentation0.0000003813InformativeDirect
Mammalian Phenotype (MP)abnormal liver physiology0.000003467InformativeDirect
Mammalian Phenotype (MP)abnormal adaptive thermogenesis0.00006303InformativeDirect
Mammalian Phenotype (MP)increased apoptosis0.0001353InformativeDirect
Mammalian Phenotype (MP)increased susceptibility to infection0.000242InformativeDirect
Mammalian Phenotype (MP)abnormal circulating leptin level0.0003293InformativeDirect
Mammalian Phenotype (MP)decreased cell proliferation0.0003412InformativeDirect
Mammalian Phenotype (MP)altered tumor pathology0.000875InformativeDirect
Mammalian Phenotype (MP)increased body weight0.001123InformativeInherited
Mammalian Phenotype (MP)abnormal female reproductive gland morphology0.001147InformativeInherited
Mammalian Phenotype (MP)abnormal internal female genitalia morphology0.002378InformativeInherited
Mammalian Phenotype (MP)abnormal adipose tissue amount0.009365InformativeInherited
Mammalian Phenotype (MP)abnormal gland physiology0.01005InformativeInherited
Mammalian Phenotype (MP)abnormal T cell differentiation0.01338InformativeInherited
Mammalian Phenotype (MP)abnormal consumption behavior0.04326InformativeInherited
Mammalian Phenotype (MP)abnormal pancreas morphology0.05124InformativeInherited
Mammalian Phenotype (MP)abnormal glucose homeostasis0.05144InformativeInherited
Mammalian Phenotype (MP)abnormal interferon level0.0523InformativeInherited
Mammalian Phenotype (MP)abnormal triglyceride level0.1354InformativeInherited
Mammalian Phenotype (MP)abnormal T cell physiology0.1457InformativeInherited
Mammalian Phenotype (MP)abnormal circulating lipid level0.1657InformativeInherited
Mammalian Phenotype (MP)abnormal interferon secretion0.2327InformativeInherited
Mammalian Phenotype (MP)abnormal effector T cell morphology0.2473InformativeInherited
Mammalian Phenotype (MP)abnormal natural killer cell mediated cytotoxicity0.3234InformativeInherited
Mammalian Phenotype (MP)abnormal alpha-beta T cell morphology0.3298InformativeInherited
Mammalian Phenotype (MP)abnormal erythroid lineage cell morphology0.3702InformativeInherited
Mammalian Phenotype (MP)abnormal T cell activation0.00000002768Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mammary gland epithelium physiology0.0000001538Highly InformativeDirect
Mammalian Phenotype (MP)abnormal CD4-positive, alpha beta T cell morphology0.0000001601Highly InformativeDirect
Mammalian Phenotype (MP)abnormal level of surface class II molecules0.000000181Highly InformativeDirect
Mammalian Phenotype (MP)increased interferon-gamma secretion0.000001122Highly InformativeDirect
Mammalian Phenotype (MP)impaired adaptive thermogenesis0.000001593Highly InformativeDirect
Mammalian Phenotype (MP)increased percent body fat/body weight0.000005281Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating insulin-like growth factor I level0.000005935Highly InformativeDirect
Mammalian Phenotype (MP)decreased mean corpuscular hemoglobin0.00000748Highly InformativeDirect
Mammalian Phenotype (MP)obese0.0000211Highly InformativeDirect
Mammalian Phenotype (MP)abnormal corpus luteum morphology0.00003233Highly InformativeDirect
Mammalian Phenotype (MP)increased lean body mass0.00007842Highly InformativeDirect
Mammalian Phenotype (MP)increased total body fat amount0.0001039Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating triglyceride level0.0001347Highly InformativeDirect
Mammalian Phenotype (MP)abnormal endocrine pancreas secretion0.0001644Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pancreatic beta cell physiology0.0002383Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating insulin level0.0002861Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pancreatic islet morphology0.0004472Highly InformativeDirect
Mammalian Phenotype (MP)decreased lean body mass0.0005282Highly InformativeDirect
Mammalian Phenotype (MP)abnormal fat pad morphology0.0006699Highly InformativeDirect
Mammalian Phenotype (MP)abnormal food intake0.002537Highly InformativeInherited
Mammalian Phenotype (MP)abnormal liver size0.08391Highly InformativeInherited

Document: MP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0Moderately InformativeDirect
Zebrafish Anatomy (ZA)portion of organism substance0Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)brain0Moderately InformativeDirect

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation0Moderately InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
DomainSH2 domain0InformativeDirect
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationDNA-binding0Moderately InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation0.0001045Moderately InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR013799 SSF48092 Protein matches
Abstract

This entry represents the N-terminal domain, which is responsible for protein interactions. This domain has a multi-helical structure that can be subdivided into two structural sub-domains.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Transcription factor STAT-4 N-domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Transcription factor STAT-4 N-domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]