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Heme-dependent peroxidases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Heme-dependent peroxidases [ 48112]
Superfamily:   Heme-dependent peroxidases [ 48113] (3)
Families:   CCP-like [ 48114] (4)
  Catalase-peroxidase KatG [ 74753]
  Myeloperoxidase-like [ 48132] (2)


Superfamily statistics
Genomes (1,403) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 14,907 42,681 113
Proteins 13,347 34,187 104


Functional annotation
General category Metabolism
Detailed category Redox

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus0.0000088630Least InformativeDirect
Biological Process (BP)multicellular organismal process0.041510.00001402Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.44431Least InformativeInherited
Biological Process (BP)response to external stimulus0.30710.002885Moderately InformativeInherited
Biological Process (BP)multi-organism process0.0073540Moderately InformativeInherited
Biological Process (BP)response to biotic stimulus0.016020.00000000003797Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.22070.1079Moderately InformativeInherited
Biological Process (BP)reproduction0.0013710.001349Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.38641Moderately InformativeInherited
Biological Process (BP)response to endogenous stimulus0.029511Moderately InformativeInherited
Biological Process (BP)response to organic substance0.68430.1677Moderately InformativeInherited
Biological Process (BP)reproductive system development0.00000052290.00007341InformativeDirect
Biological Process (BP)developmental process involved in reproduction0.00037070.01175InformativeInherited
Biological Process (BP)post-embryonic development0.0000002420.005368InformativeInherited
Biological Process (BP)single organism reproductive process0.00016620.001349InformativeInherited
Biological Process (BP)cellular component morphogenesis0.00027620.0733InformativeInherited
Biological Process (BP)growth0.002870.01871InformativeInherited
Biological Process (BP)seed development0.00000014670.0005509Highly InformativeDirect
Biological Process (BP)hydrogen peroxide metabolic process0.25650.000005262Highly InformativeInherited
Biological Process (BP)cell growth0.0000037020.005883Highly InformativeInherited
Biological Process (BP)developmental growth involved in morphogenesis0.0000024590.01797Highly InformativeInherited
Molecular Function (MF)oxidoreductase activity00Moderately InformativeDirect
Molecular Function (MF)peroxidase activity00Highly InformativeDirect
Cellular Component (CC)intracellular organelle part0.93071Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.0041041Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.62921Least InformativeInherited
Cellular Component (CC)vacuole0.00011850.00009131Moderately InformativeDirect
Cellular Component (CC)extracellular region part0.087120.0000002611Moderately InformativeInherited
Cellular Component (CC)external encapsulating structure00InformativeDirect
Cellular Component (CC)plastid0.00068120.03485InformativeInherited
Cellular Component (CC)plant-type cell wall0.00000000009450.00000002001Highly InformativeDirect
Cellular Component (CC)extracellular matrix component0.000000000000070050.00002061Highly InformativeDirect
Cellular Component (CC)symplast0.000000068660.0001493Highly InformativeDirect
Cellular Component (CC)cell-cell junction0.00000012370.0163Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0.00001402 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.0002916 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) biosynthetic process 0.04463 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.7274 Least Informative Inherited
Biological Process (BP) biological regulation 0.04126 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) lipid metabolic process 0.00000003044 Moderately Informative Direct
Biological Process (BP) defense response 0.00000003574 Moderately Informative Direct
Biological Process (BP) response to biotic stimulus 0.00000000003797 Moderately Informative Direct
Biological Process (BP) monocarboxylic acid metabolic process 0.00000002042 Moderately Informative Direct
Biological Process (BP) small molecule biosynthetic process 0.0000000001961 Moderately Informative Direct
Biological Process (BP) multi-organism process 0 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.00002123 Moderately Informative Direct
Biological Process (BP) animal organ development 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.006437 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.1079 Moderately Informative Inherited
Biological Process (BP) reproduction 0.001349 Moderately Informative Inherited
Biological Process (BP) cell communication 0.8493 Moderately Informative Inherited
Biological Process (BP) single organism signaling 0.8612 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.1677 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.002885 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.1675 Moderately Informative Inherited
Biological Process (BP) cellular modified amino acid metabolic process 0.000005 Informative Direct
Biological Process (BP) fatty acid metabolic process 0.0000000000007158 Informative Direct
Biological Process (BP) response to oxidative stress 0.0001736 Informative Direct
Biological Process (BP) response to bacterium 0.0004913 Informative Direct
Biological Process (BP) regulation of hormone levels 0.0007514 Informative Direct
Biological Process (BP) response to organic cyclic compound 0.00004976 Informative Direct
Biological Process (BP) reproductive system development 0.00007341 Informative Direct
Biological Process (BP) monocarboxylic acid biosynthetic process 0.000000000001725 Informative Direct
Biological Process (BP) embryo development 0.9271 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.01175 Informative Inherited
Biological Process (BP) post-embryonic development 0.005368 Informative Inherited
Biological Process (BP) single organism reproductive process 0.001349 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 0.001302 Informative Inherited
Biological Process (BP) response to nitrogen compound 0.02236 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.0733 Informative Inherited
Biological Process (BP) growth 0.01871 Informative Inherited
Biological Process (BP) system process 0.0429 Informative Inherited
Biological Process (BP) unsaturated fatty acid biosynthetic process 0.0000000005288 Highly Informative Direct
Biological Process (BP) icosanoid metabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of blood pressure 0.0000000000001015 Highly Informative Direct
Biological Process (BP) response to purine-containing compound 0.00000000007332 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 0.00000005384 Highly Informative Direct
Biological Process (BP) cytokine-mediated signaling pathway 0.00000000002818 Highly Informative Direct
Biological Process (BP) hydrogen peroxide metabolic process 0.000005262 Highly Informative Direct
Biological Process (BP) response to organophosphorus 0.000000000001447 Highly Informative Direct
Biological Process (BP) seed development 0.0005509 Highly Informative Direct
Biological Process (BP) fatty acid derivative biosynthetic process 0 Highly Informative Direct
Biological Process (BP) embryonic organ development 0.1806 Highly Informative Inherited
Biological Process (BP) cell growth 0.005883 Highly Informative Inherited
Biological Process (BP) developmental growth involved in morphogenesis 0.01797 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) tetrapyrrole binding 0 Informative Direct
Molecular Function (MF) peroxidase activity 0 Highly Informative Direct
Molecular Function (MF) heme binding 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 0.2757 Highly Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) vacuole 0.00009131 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.0000002611 Moderately Informative Direct
Cellular Component (CC) external encapsulating structure 0 Informative Direct
Cellular Component (CC) plastid 0.03485 Informative Inherited
Cellular Component (CC) plant-type cell wall 0.00000002001 Highly Informative Direct
Cellular Component (CC) extracellular matrix component 0.00002061 Highly Informative Direct
Cellular Component (CC) symplast 0.0001493 Highly Informative Direct
Cellular Component (CC) cell-cell junction 0.0163 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on NADH or NADPH1Moderately InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or red1Moderately InformativeInherited
Enzyme Commission (EC)Miscellaneous (requires further characterization)0InformativeDirect
Enzyme Commission (EC)Peroxidases0.1679InformativeInherited
Enzyme Commission (EC)With a oxygen as acceptor0Highly InformativeDirect
Enzyme Commission (EC)Peroxidase0.000000000000001867Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processLipid metabolism0.6052Moderately InformativeInherited
Biological processFatty acid metabolism0.0000002966InformativeDirect
Biological processLipid biosynthesis0.002697InformativeInherited
Biological processProstaglandin biosynthesis0Highly InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0.001376Moderately InformativeInherited
Cellular componentVacuole0.000000000005659InformativeDirect
Cellular componentMicrosome0.000000000000001952Highly InformativeDirect
DomainSignal0Least InformativeDirect
DomainEGF-like domain0.000006612InformativeDirect
DomainSushi0.00009397Highly InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionIron0Moderately InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionHeme0InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationPeroxidase0Highly InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationPyrrolidone carboxylic acid0InformativeDirect
Post-translational modificationS-nitrosylation0.0000006293InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR010255 SSF48113 Protein matches
Abstract Peroxidases are haem-containing enzymes that use hydrogen peroxide as the electron acceptor to catalyse a number of oxidative reactions. Most haem peroxidases follow the reaction scheme: Fe3+ + H2O2 --> [Fe4+=O]R' (Compound I) + H2O [Fe4+=O]R' + substrate --> [Fe4+=O]R (Compound II) + oxidised substrate [Fe4+=O]R + substrate --> Fe3+ + H2O + oxidised substrate

In this mechanism, the enzyme reacts with one equivalent of H2O2 to give [Fe4+=O]R' (compound I). This is a two-electron oxidation/reduction reaction where H2O2 is reduced to water and the enzyme is oxidised. One oxidising equivalent resides on iron, giving the oxyferryl [PubMed8062820] intermediate, while in many peroxidases the porphyrin (R) is oxidised to the porphyrin pi-cation radical (R'). Compound I then oxidises an organic substrate to give a substrate radical [PubMed7922023].

Haem peroxidases include two superfamilies: one found in bacteria, fungi, plants and the second found in animals. The animal peroxidases comprise a group of homologous proteins that differ markedly from the plant/fungal/bacterial peroxidases in primary, secondary and tertiary structure, but which share with them a common function. Animal peroxidases probably arose independently of the plant/fungal/bacterial peroxidase superfamily and most likely belong to a different gene family. The crystal structures of a number of these proteins show that the active sites of animal peroxidase and plant/fungal/bacterial peroxidases are remarkably similar [PubMed10403190].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 27 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Heme-dependent peroxidases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 27 hidden Markov models representing the Heme-dependent peroxidases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]