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An anticodon-binding domain of class I aminoacyl-tRNA synthetases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   An anticodon-binding domain of class I aminoacyl-tRNA synthetases [ 48162]
Superfamily:   An anticodon-binding domain of class I aminoacyl-tRNA synthetases [ 48163] (2)
Families:   C-terminal domain of glutamyl-tRNA synthetase (GluRS) [ 48164]
  C-terminal domain of class I lysyl-tRNA synthetase [ 74759]


Superfamily statistics
Genomes (3,095) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 3,904 23,274 3
Proteins 3,894 23,236 3


Functional annotation
General category Information
Detailed category Translation

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) heterocycle metabolic process 0.000002832 Least Informative Direct
Biological Process (BP) biosynthetic process 0.000002841 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 0.000003149 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.000006052 Least Informative Direct
Biological Process (BP) cellular nitrogen compound metabolic process 0.000008159 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.00002745 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0.000107 Least Informative Direct
Biological Process (BP) macromolecule metabolic process 0.000188 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.01173 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.002295 Least Informative Inherited
Biological Process (BP) amide biosynthetic process 0.000000000001483 Moderately Informative Direct
Biological Process (BP) peptide metabolic process 0.000000000001973 Moderately Informative Direct
Biological Process (BP) cellular amino acid metabolic process 0.000000000005527 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 0.000000002195 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 0.000000002791 Moderately Informative Direct
Biological Process (BP) gene expression 0.000000008703 Moderately Informative Direct
Biological Process (BP) tRNA metabolic process 0 Informative Direct
Molecular Function (MF) ligase activity 0.00000000000001173 Informative Direct
Cellular Component (CC) cytoplasmic part 0.00001355 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.001724 Least Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Least InformativeDirect
Enzyme Commission (EC)Ligases forming aminoacyl-tRNA and related compoun0Moderately InformativeDirect
Enzyme Commission (EC)Glutamate--tRNA ligase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Moderately InformativeDirect
Enzyme Commission (EC)Ligases forming aminoacyl-tRNA and related compounds0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processProtein biosynthesis0InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Post-translational modificationAminoacyl-tRNA synthetase0InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR008925 SSF48163 Protein matches
Abstract

Structurally, an alpha-helix-bundle anticodon-binding domain characterises the class Ia synthetases, whereas the class Ib synthetases, GlnRS and GluRS have distinct anticodon-binding domains. The Rossmann-fold and anticodon-binding domains are connected by a beta-alpha-alpha-beta-alpha topology ('SC fold') domain that contains the class I specific KMSKS motif [PubMed10673435].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a An anticodon-binding domain of class I aminoacyl-tRNA synthetases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the An anticodon-binding domain of class I aminoacyl-tRNA synthetases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]