SUPERFAMILY 1.75 HMM library and genome assignments server


Cytochrome P450 superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Cytochrome P450 [ 48263]
Superfamily:   Cytochrome P450 [ 48264]
Families:   Cytochrome P450 [ 48265] (22)


Superfamily statistics
Genomes (1,306) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 57,789 77,510 76
Proteins 56,410 76,848 76


Functional annotation
General category Metabolism
Detailed category Redox

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biosynthetic process1.326e-100Least InformativeDirect
Biological Process (BP)single-organism metabolic process3.921e-140Least InformativeDirect
Biological Process (BP)organic cyclic compound metabolic process0.00055690Least InformativeDirect
Biological Process (BP)heterocycle metabolic process11Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)response to stimulus0.26311Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.19051Least InformativeInherited
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)lipid metabolic process00Moderately InformativeDirect
Biological Process (BP)monocarboxylic acid metabolic process2.734e-110Moderately InformativeDirect
Biological Process (BP)single-organism biosynthetic process00Moderately InformativeDirect
Biological Process (BP)cellular response to chemical stimulus3.897e-072.878e-08Moderately InformativeDirect
Biological Process (BP)organic cyclic compound biosynthetic process1.108e-060Moderately InformativeDirect
Biological Process (BP)organic hydroxy compound metabolic process1.29e-120Moderately InformativeDirect
Biological Process (BP)regulation of developmental process6.158e-051Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process0.079220.2507Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.050051Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.0033291Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus2.792e-060.857Moderately InformativeInherited
Biological Process (BP)response to organic substance0.021611Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound11Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.004271Moderately InformativeInherited
Biological Process (BP)regulation of macromolecule biosynthetic process0.0059681Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.014431Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process9.206e-051Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.0010781Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process4.446e-051Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.061581Moderately InformativeInherited
Biological Process (BP)positive regulation of response to stimulus0.00019831Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.00084921Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.051580.0008323Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.65021Moderately InformativeInherited
Biological Process (BP)alcohol metabolic process1.071e-110InformativeDirect
Biological Process (BP)regulation of hormone levels1.517e-060InformativeDirect
Biological Process (BP)monocarboxylic acid biosynthetic process1.28e-100.0002405InformativeDirect
Biological Process (BP)response to cytokine stimulus7.976e-070.04178InformativeInherited
Biological Process (BP)cellular chemical homeostasis0.62251InformativeInherited
Biological Process (BP)cellular response to oxygen-containing compound0.99961InformativeInherited
Biological Process (BP)response to lipid0.95920.03989InformativeInherited
Biological Process (BP)response to organic cyclic compound0.74023.041e-06InformativeInherited
Biological Process (BP)regulation of response to external stimulus1.233e-090.001519InformativeInherited
Biological Process (BP)fatty acid metabolic process0.0016372.887e-10InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis3.162e-050.755InformativeInherited
Biological Process (BP)positive regulation of developmental process5.309e-100.4171InformativeInherited
Biological Process (BP)negative regulation of biosynthetic process3.584e-071InformativeInherited
Biological Process (BP)negative regulation of nitrogen compound metabolic process2.514e-091InformativeInherited
Biological Process (BP)organic hydroxy compound biosynthetic process0.081011.099e-13InformativeInherited
Biological Process (BP)positive regulation of signal transduction5.321e-071InformativeInherited
Biological Process (BP)regulation of defense response4.757e-090.1069InformativeInherited
Biological Process (BP)negative regulation of response to stimulus1.632e-070.791InformativeInherited
Biological Process (BP)secondary metabolic process0.0037670InformativeInherited
Biological Process (BP)regulation of lipid metabolic process0.058070.1992InformativeInherited
Biological Process (BP)glycosyl compound biosynthetic process0.21980.02153InformativeInherited
Biological Process (BP)vitamin metabolic process0.38577.67e-12InformativeInherited
Biological Process (BP)isoprenoid metabolic process0.24931.048e-10InformativeInherited
Biological Process (BP)lipid catabolic process0.0016677.698e-07InformativeInherited
Biological Process (BP)response to hypoxia1.912e-133.486e-05Highly InformativeDirect
Biological Process (BP)icosanoid metabolic process1.199e-120Highly InformativeDirect
Biological Process (BP)steroid biosynthetic process2.761e-100Highly InformativeDirect
Biological Process (BP)steroid catabolic process3.238e-099.575e-14Highly InformativeDirect
Biological Process (BP)xenobiotic metabolic process7.248e-070Highly InformativeDirect
Biological Process (BP)sterol metabolic process0.00010086.193e-07Highly InformativeDirect
Biological Process (BP)glycoside metabolic process4.585e-059.269e-07Highly InformativeDirect
Biological Process (BP)antibiotic biosynthetic process4.096e-082.556e-06Highly InformativeDirect
Biological Process (BP)negative regulation of response to external stimulus04.423e-07Highly InformativeDirect
Biological Process (BP)unsaturated fatty acid metabolic process1.138e-080Highly InformativeDirect
Biological Process (BP)cellular hormone metabolic process0.0004540Highly InformativeDirect
Biological Process (BP)hormone biosynthetic process1.314e-060Highly InformativeDirect
Biological Process (BP)negative regulation of sequence-specific DNA binding transcription factor activity02.015e-12Highly InformativeDirect
Biological Process (BP)regulation of nitric oxide biosynthetic process09.148e-15Highly InformativeDirect
Biological Process (BP)regulation of angiogenesis02.387e-07Highly InformativeDirect
Biological Process (BP)regulation of steroid biosynthetic process0.0001941.245e-05Highly InformativeDirect
Biological Process (BP)fatty acid derivative biosynthetic process9.34e-141.778e-14Highly InformativeDirect
Biological Process (BP)response to alcohol0.56890.003195Highly InformativeInherited
Biological Process (BP)response to carbohydrate stimulus0.076720.3Highly InformativeInherited
Biological Process (BP)carbohydrate homeostasis0.012480.2657Highly InformativeInherited
Biological Process (BP)regulation of cellular ketone metabolic process0.010050.09987Highly InformativeInherited
Biological Process (BP)polyol metabolic process11Highly InformativeInherited
Biological Process (BP)secondary metabolite biosynthetic process0.057999.967e-05Highly InformativeInherited
Biological Process (BP)alcohol catabolic process6.673e-050.03247Highly InformativeInherited
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)oxidoreductase activity00Moderately InformativeDirect
Molecular Function (MF)isomerase activity5.389e-070.01099Moderately InformativeInherited
Molecular Function (MF)cation binding0.03381Moderately InformativeInherited
Molecular Function (MF)intramolecular oxidoreductase activity3.899e-154.975e-13InformativeDirect
Molecular Function (MF)tetrapyrrole binding00InformativeDirect
Molecular Function (MF)monooxygenase activity00Highly InformativeDirect
Molecular Function (MF)iron ion binding4.011e-060.0001502Highly InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge00Highly InformativeDirect
Molecular Function (MF)heme binding00Highly InformativeDirect
Cellular Component (CC)membrane0.90581Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)endoplasmic reticulum6.179e-120Moderately InformativeDirect
Cellular Component (CC)plasma membrane0.41151Moderately InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biosynthetic process 0 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) monocarboxylic acid metabolic process 0 Moderately Informative Direct
Biological Process (BP) single-organism biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.0008323 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 2.878e-08 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.857 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.2507 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.5337 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cofactor metabolic process 0.2868 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.05079 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) alcohol metabolic process 0 Informative Direct
Biological Process (BP) fatty acid metabolic process 2.887e-10 Informative Direct
Biological Process (BP) isoprenoid metabolic process 1.048e-10 Informative Direct
Biological Process (BP) vitamin metabolic process 7.67e-12 Informative Direct
Biological Process (BP) regulation of hormone levels 0 Informative Direct
Biological Process (BP) response to organic cyclic compound 3.041e-06 Informative Direct
Biological Process (BP) lipid catabolic process 7.698e-07 Informative Direct
Biological Process (BP) secondary metabolic process 0 Informative Direct
Biological Process (BP) cellular ketone metabolic process 0 Informative Direct
Biological Process (BP) monocarboxylic acid biosynthetic process 0.0002405 Informative Direct
Biological Process (BP) organic hydroxy compound biosynthetic process 1.099e-13 Informative Direct
Biological Process (BP) biological adhesion 1 Informative Inherited
Biological Process (BP) response to cytokine stimulus 0.04178 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 1 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) response to lipid 0.03989 Informative Inherited
Biological Process (BP) sensory organ development 1 Informative Inherited
Biological Process (BP) cardiovascular system development 1 Informative Inherited
Biological Process (BP) cation homeostasis 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.755 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.4171 Informative Inherited
Biological Process (BP) coenzyme biosynthetic process 0.006016 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 1 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 0.3883 Informative Inherited
Biological Process (BP) regulation of defense response 0.1069 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.791 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.001519 Informative Inherited
Biological Process (BP) cellular aldehyde metabolic process 0.01037 Informative Inherited
Biological Process (BP) phospholipid metabolic process 1 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.1992 Informative Inherited
Biological Process (BP) glycosyl compound biosynthetic process 0.02153 Informative Inherited
Biological Process (BP) sulfur compound biosynthetic process 0.3538 Informative Inherited
Biological Process (BP) anion transport 1 Informative Inherited
Biological Process (BP) nitrogen compound transport 1 Informative Inherited
Biological Process (BP) cellular component morphogenesis 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) response to inorganic substance 0.6756 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 1 Informative Inherited
Biological Process (BP) cellular biogenic amine metabolic process 1 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.01838 Informative Inherited
Biological Process (BP) blood circulation 0.001171 Informative Inherited
Biological Process (BP) response to hypoxia 3.486e-05 Highly Informative Direct
Biological Process (BP) tryptophan metabolic process 7.011e-06 Highly Informative Direct
Biological Process (BP) icosanoid metabolic process 0 Highly Informative Direct
Biological Process (BP) steroid biosynthetic process 0 Highly Informative Direct
Biological Process (BP) steroid catabolic process 9.575e-14 Highly Informative Direct
Biological Process (BP) xenobiotic metabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of blood pressure 1.124e-05 Highly Informative Direct
Biological Process (BP) isoprenoid biosynthetic process 4.079e-06 Highly Informative Direct
Biological Process (BP) toxin metabolic process 0 Highly Informative Direct
Biological Process (BP) response to toxic substance 1.655e-05 Highly Informative Direct
Biological Process (BP) phenylpropanoid metabolic process 1.29e-06 Highly Informative Direct
Biological Process (BP) sterol metabolic process 6.193e-07 Highly Informative Direct
Biological Process (BP) glycoside metabolic process 9.269e-07 Highly Informative Direct
Biological Process (BP) antibiotic biosynthetic process 2.556e-06 Highly Informative Direct
Biological Process (BP) negative regulation of response to external stimulus 4.423e-07 Highly Informative Direct
Biological Process (BP) unsaturated fatty acid metabolic process 0 Highly Informative Direct
Biological Process (BP) cellular hormone metabolic process 0 Highly Informative Direct
Biological Process (BP) quinone cofactor metabolic process 8.648e-09 Highly Informative Direct
Biological Process (BP) cellular biogenic amine catabolic process 0.0003604 Highly Informative Direct
Biological Process (BP) indole-containing compound biosynthetic process 3.309e-05 Highly Informative Direct
Biological Process (BP) hormone biosynthetic process 0 Highly Informative Direct
Biological Process (BP) negative regulation of sequence-specific DNA binding transcription factor activity 2.015e-12 Highly Informative Direct
Biological Process (BP) secondary metabolite biosynthetic process 9.967e-05 Highly Informative Direct
Biological Process (BP) regulation of nitric oxide biosynthetic process 9.148e-15 Highly Informative Direct
Biological Process (BP) regulation of angiogenesis 2.387e-07 Highly Informative Direct
Biological Process (BP) regulation of steroid biosynthetic process 1.245e-05 Highly Informative Direct
Biological Process (BP) regulation of coagulation 4.701e-05 Highly Informative Direct
Biological Process (BP) monovalent inorganic cation homeostasis 0.0001995 Highly Informative Direct
Biological Process (BP) regulation of wound healing 0.0004611 Highly Informative Direct
Biological Process (BP) regulation of hemostasis 2.898e-05 Highly Informative Direct
Biological Process (BP) fatty acid derivative biosynthetic process 1.778e-14 Highly Informative Direct
Biological Process (BP) cell adhesion 1 Highly Informative Inherited
Biological Process (BP) response to alcohol 0.003195 Highly Informative Inherited
Biological Process (BP) response to carbohydrate stimulus 0.3 Highly Informative Inherited
Biological Process (BP) carbohydrate homeostasis 0.2657 Highly Informative Inherited
Biological Process (BP) regulation of cellular ketone metabolic process 0.09987 Highly Informative Inherited
Biological Process (BP) retina development in camera-type eye 0.2028 Highly Informative Inherited
Biological Process (BP) response to drug 0.007305 Highly Informative Inherited
Biological Process (BP) quinone biosynthetic process 1 Highly Informative Inherited
Biological Process (BP) polyol metabolic process 1 Highly Informative Inherited
Biological Process (BP) fatty acid catabolic process 1 Highly Informative Inherited
Biological Process (BP) retinoid metabolic process 1 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.6884 Highly Informative Inherited
Biological Process (BP) alcohol catabolic process 0.03247 Highly Informative Inherited
Biological Process (BP) inorganic anion transport 0.1906 Highly Informative Inherited
Biological Process (BP) cellular component assembly involved in morphogenesis 0.9701 Highly Informative Inherited
Biological Process (BP) external encapsulating structure organization 0.05382 Highly Informative Inherited
Biological Process (BP) lipid modification 1 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.6225 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) cation binding 1 Moderately Informative Inherited
Molecular Function (MF) isomerase activity 0.01099 Moderately Informative Inherited
Molecular Function (MF) intramolecular oxidoreductase activity 4.975e-13 Informative Direct
Molecular Function (MF) tetrapyrrole binding 0 Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on CH-OH group of donors 1 Informative Inherited
Molecular Function (MF) monooxygenase activity 0 Highly Informative Direct
Molecular Function (MF) iron ion binding 0.0001502 Highly Informative Direct
Molecular Function (MF) drug binding 0.0003465 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 0 Highly Informative Direct
Molecular Function (MF) heme binding 0 Highly Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0 Moderately Informative Direct
Cellular Component (CC) endomembrane system 3.193e-06 Moderately Informative Direct
Cellular Component (CC) plasma membrane 1 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.03709 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum membrane 0 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Isomerases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0Moderately InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0.7611Moderately InformativeInherited
Enzyme Commission (EC)Hydro-lyases1Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Miscellaneous (requires further characterization)1InformativeInherited
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation0.02235InformativeInherited
Enzyme Commission (EC)Other intramolecular oxidoreductases0Highly InformativeDirect
Enzyme Commission (EC)With reduced flavin or flavoprotein as one donor, 0Highly InformativeDirect
Enzyme Commission (EC)With a reduced iron-sulfur protein as one donor, a1.495e-08Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)endocrine system disease0.02164Moderately InformativeInherited
Disease Ontology (DO)artery disease0.1138Moderately InformativeInherited
Disease Ontology (DO)connective tissue disease0.1942Moderately InformativeInherited
Disease Ontology (DO)physical disorder0.03841InformativeInherited
Disease Ontology (DO)coronary artery disease0.5892InformativeInherited
Disease Ontology (DO)hypospadias5.816e-05Highly InformativeDirect
Disease Ontology (DO)bone resorption disease0.0001184Highly InformativeDirect
Disease Ontology (DO)hyperandrogenism0.0002118Highly InformativeDirect
Disease Ontology (DO)thoracic disease0.0003905Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Puberty and gonadal disorders0.07106InformativeInherited
Phenotypic Abnormality (PA)Adrenogenital syndrome7.846e-06Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.3052Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.8143Least InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.01886Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.1501Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.2078Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.4387Moderately InformativeInherited
Mammalian Phenotype (MP)digestive/alimentary phenotype0.5659Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal systemic arterial blood pressure0.000105InformativeDirect
Mammalian Phenotype (MP)abnormal digestive system physiology0.4132InformativeInherited
Mammalian Phenotype (MP)abnormal xenobiotic pharmacokinetics2.897e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating aldosterone level0.0002673Highly InformativeDirect
Mammalian Phenotype (MP)abnormal fat-soluble vitamin level0.0002673Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.2164Least InformativeInherited
Worm Phenotype (WP)metal response variant0.0001096InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system subdivision0.04051Least InformativeInherited
Fly Anatomy (FA)anatomical group0.1119Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.2504Least InformativeInherited
Fly Anatomy (FA)organ system0.2589Least InformativeInherited
Fly Anatomy (FA)cell0.5655Least InformativeInherited
Fly Anatomy (FA)larva0.5948Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)acellular anatomical structure0.004302Moderately InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.01228Moderately InformativeInherited
Fly Anatomy (FA)epithelium0.03215Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.1314Moderately InformativeInherited
Fly Anatomy (FA)developing material anatomical entity0.3653Moderately InformativeInherited
Fly Anatomy (FA)late embryo0.5201Moderately InformativeInherited
Fly Anatomy (FA)commissure6.59e-06InformativeDirect
Fly Anatomy (FA)midgut2.336e-05InformativeDirect
Fly Anatomy (FA)alimentary canal0.0001632InformativeDirect
Fly Anatomy (FA)cuboidal/columnar epithelium0.0006333InformativeDirect
Fly Anatomy (FA)embryonic/larval digestive system0.001394InformativeInherited
Fly Anatomy (FA)embryonic/larval integumentary system0.009182InformativeInherited
Fly Anatomy (FA)primordium0.021InformativeInherited
Fly Anatomy (FA)embryonic/larval central nervous system0.1108InformativeInherited
Fly Anatomy (FA)hindgut2.191e-06Highly InformativeDirect
Fly Anatomy (FA)neuropil glial sheath3.398e-06Highly InformativeDirect
Fly Anatomy (FA)presumptive embryonic/larval central nervous system1.034e-05Highly InformativeDirect
Fly Anatomy (FA)midgut primordium7.199e-05Highly InformativeDirect
Fly Anatomy (FA)embryonic epidermis0.0001061Highly InformativeDirect
Fly Anatomy (FA)embryonic head0.0003984Highly InformativeDirect
Fly Anatomy (FA)CNS glial cell0.000639Highly InformativeDirect
Fly Anatomy (FA)embryonic/first instar larval cuticle0.0008539Highly InformativeDirect

Document: FA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)fruit0.01248InformativeInherited

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Carbon-carbon lyases0.1435Moderately InformativeInherited
Enzyme Commission (EC)Acting on the CH-OH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases1Moderately InformativeInherited
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen0InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0.9157InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1InformativeInherited
Enzyme Commission (EC)Acting on single donors with incorporation of molecular oxygen1InformativeInherited
Enzyme Commission (EC)Acting on NADH or NADPH1InformativeInherited
Enzyme Commission (EC)Intramolecular transferases (mutases)1InformativeInherited
Enzyme Commission (EC)With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen0Highly InformativeDirect
Enzyme Commission (EC)Other intramolecular oxidoreductases0Highly InformativeDirect
Enzyme Commission (EC)Aldehyde-lyases4.839e-16Highly InformativeDirect
Enzyme Commission (EC)Transferring hydroxy groups3.316e-08Highly InformativeDirect
Enzyme Commission (EC)With a heme protein as acceptor8.29e-05Highly InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation of one atom of oxygen0.002176Highly InformativeInherited
Enzyme Commission (EC)With incorporation of two atoms of oxygen0.01737Highly InformativeInherited
Enzyme Commission (EC)Miscellaneous (requires further characterization)1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

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KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processLipid metabolism0Moderately InformativeDirect
Biological processSteroid metabolism0InformativeDirect
Biological processFatty acid metabolism1InformativeInherited
Biological processLipid biosynthesis1InformativeInherited
Biological processProstaglandin biosynthesis0Highly InformativeDirect
Biological processSteroid biosynthesis0Highly InformativeDirect
Biological processGrowth regulation8.564e-11Highly InformativeDirect
Biological processAntibiotic biosynthesis4.435e-09Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentMicrosome0Highly InformativeDirect
Coding sequence diversityPolymorphism2.724e-06Moderately InformativeDirect
DiseaseDisease mutation0.0001306Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
DomainTransit peptide7.463e-07Moderately InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionIron0Moderately InformativeDirect
Molecular functionHeme0InformativeDirect
Molecular functionNADP0InformativeDirect
Molecular functionLipid-binding0.3736InformativeInherited
Molecular functionSteroid-binding5.2e-09Highly InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationMonooxygenase0Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)lipid metabolism0Least InformativeDirect
UniPathway (UP)aromatic compound metabolism0.7338Least InformativeInherited
UniPathway (UP)secondary metabolite metabolism0Moderately InformativeDirect
UniPathway (UP)alcohol metabolism0Moderately InformativeDirect
UniPathway (UP)aromatic compound biosynthesis2.29e-10Moderately InformativeDirect
UniPathway (UP)nitrogen metabolism2.175e-05Moderately InformativeDirect
UniPathway (UP)fatty acid metabolism1Moderately InformativeInherited
UniPathway (UP)lipid biosynthesis1Moderately InformativeInherited
UniPathway (UP)antibiotic biosynthesis0InformativeDirect
UniPathway (UP)alkaloid metabolism0InformativeDirect
UniPathway (UP)terpene metabolism0InformativeDirect
UniPathway (UP)alcohol biosynthesis0InformativeDirect
UniPathway (UP)phenylpropanoid biosynthesis0InformativeDirect
UniPathway (UP)toxin biosynthesis4.527e-16InformativeDirect
UniPathway (UP)pigment biosynthesis0.0008778InformativeDirect
UniPathway (UP)hormone biosynthesis0.004211InformativeInherited
UniPathway (UP)plant hormone metabolism0.4949InformativeInherited
UniPathway (UP)flavonoid metabolism0.9852InformativeInherited
UniPathway (UP)mycotoxin biosynthesis0Highly InformativeDirect
UniPathway (UP)oxylipin biosynthesis1.041e-11Highly InformativeDirect
UniPathway (UP)anthocyanin biosynthesis6.136e-10Highly InformativeDirect
UniPathway (UP)erythromycin biosynthesis0.0006821Highly InformativeDirect
UniPathway (UP)steroid hormone biosynthesis0.1379Highly InformativeInherited
UniPathway (UP)monoterpene metabolism0.5762Highly InformativeInherited
UniPathway (UP)plant hormone biosynthesis0.8317Highly InformativeInherited

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR001128 SSF48264 Protein matches
Abstract

More information about these proteins can be found at Protein of the Month: Cytochrome P450.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 23 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Cytochrome P450 domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 23 hidden Markov models representing the Cytochrome P450 superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]