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Cytochrome P450 superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Cytochrome P450 [ 48263]
Superfamily:   Cytochrome P450 [ 48264]
Families:   Cytochrome P450 [ 48265] (22)


Superfamily statistics
Genomes (1,312) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 57,785 178,018 76
Proteins 56,382 175,261 76


Functional annotation
General category Metabolism
Detailed category Redox

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biosynthetic process0.000026320.00000000000005866Least InformativeDirect
Biological Process (BP)single-organism metabolic process00Least InformativeDirect
Biological Process (BP)organic cyclic compound metabolic process0.000028240Least InformativeDirect
Biological Process (BP)heterocycle metabolic process11Least InformativeInherited
Biological Process (BP)response to stimulus0.12051Least InformativeInherited
Biological Process (BP)biological regulation0.37411Least InformativeInherited
Biological Process (BP)single-organism cellular process0.15080.03763Least InformativeInherited
Biological Process (BP)primary metabolic process11Least InformativeInherited
Biological Process (BP)lipid metabolic process00Moderately InformativeDirect
Biological Process (BP)monocarboxylic acid metabolic process00Moderately InformativeDirect
Biological Process (BP)cellular response to chemical stimulus0.000027050.00008552Moderately InformativeDirect
Biological Process (BP)organic cyclic compound biosynthetic process0.00001680.00000000000004411Moderately InformativeDirect
Biological Process (BP)negative regulation of cellular process0.010231Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process0.000036151Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process11Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process0.36841Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.00090791Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.81251Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process0.000051351Moderately InformativeInherited
Biological Process (BP)response to organic substance0.0010851Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.0001121Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.000050791Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.0043931Moderately InformativeInherited
Biological Process (BP)regulation of molecular function0.00013871Moderately InformativeInherited
Biological Process (BP)small molecule biosynthetic process0.000015970.02993Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.000010831Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.024781Moderately InformativeInherited
Biological Process (BP)regulation of cell communication0.0004851Moderately InformativeInherited
Biological Process (BP)regulation of signaling0.00048911Moderately InformativeInherited
Biological Process (BP)regulation of response to stimulus0.0072341Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.0088661Moderately InformativeInherited
Biological Process (BP)regulation of macromolecule biosynthetic process0.0033111Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.037150.0000000001523Moderately InformativeInherited
Biological Process (BP)single-organism catabolic process11Moderately InformativeInherited
Biological Process (BP)alcohol metabolic process0.000059320.000733InformativeDirect
Biological Process (BP)fatty acid metabolic process0.000037560.0000000003618InformativeDirect
Biological Process (BP)regulation of hormone levels0.00009250InformativeDirect
Biological Process (BP)organic hydroxy compound biosynthetic process0.0000017170InformativeDirect
Biological Process (BP)regulation of apoptotic process0.0000014861InformativeInherited
Biological Process (BP)cellular response to oxygen-containing compound0.90491InformativeInherited
Biological Process (BP)cellular response to lipid0.82630.2663InformativeInherited
Biological Process (BP)cellular chemical homeostasis0.58381InformativeInherited
Biological Process (BP)positive regulation of developmental process0.0000000046280.9838InformativeInherited
Biological Process (BP)positive regulation of multicellular organismal process0.000000038581InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis0.000042610.6035InformativeInherited
Biological Process (BP)negative regulation of cellular biosynthetic process0.0000012011InformativeInherited
Biological Process (BP)secondary metabolic process0.0017870InformativeInherited
Biological Process (BP)negative regulation of molecular function0.0000000037670.08736InformativeInherited
Biological Process (BP)cellular ketone metabolic process0.001470InformativeInherited
Biological Process (BP)response to organic cyclic compound0.13070.000000002967InformativeInherited
Biological Process (BP)positive regulation of signal transduction0.0000095461InformativeInherited
Biological Process (BP)regulation of response to external stimulus0.00000021370.3351InformativeInherited
Biological Process (BP)negative regulation of response to stimulus0.000000031750.8838InformativeInherited
Biological Process (BP)regulation of defense response0.00000006240.2226InformativeInherited
Biological Process (BP)regulation of lipid metabolic process0.030640.0528InformativeInherited
Biological Process (BP)lipid catabolic process0.044780.0001334InformativeInherited
Biological Process (BP)monocarboxylic acid biosynthetic process0.0000000024550.001337InformativeInherited
Biological Process (BP)response to hypoxia0.0000000000045270.0001964Highly InformativeDirect
Biological Process (BP)icosanoid metabolic process0.00000000000012040Highly InformativeDirect
Biological Process (BP)steroid biosynthetic process0.0000000011980Highly InformativeDirect
Biological Process (BP)sterol metabolic process0.000032870.00000001143Highly InformativeDirect
Biological Process (BP)antibiotic biosynthetic process0.0000000000049130.0000000574Highly InformativeDirect
Biological Process (BP)polyketide metabolic process0.0000000039650.000002138Highly InformativeDirect
Biological Process (BP)negative regulation of defense response0.00000000000062240.0000008916Highly InformativeDirect
Biological Process (BP)negative regulation of response to external stimulus0.000000000058780.00003751Highly InformativeDirect
Biological Process (BP)cellular response to decreased oxygen levels00.00000008055Highly InformativeDirect
Biological Process (BP)ketone biosynthetic process0.00074390.00000000000002102Highly InformativeDirect
Biological Process (BP)hormone biosynthetic process0.000013910Highly InformativeDirect
Biological Process (BP)negative regulation of sequence-specific DNA binding transcription factor activity00.000000000004079Highly InformativeDirect
Biological Process (BP)response to estrogen0.00029910.00001448Highly InformativeDirect
Biological Process (BP)secondary metabolite biosynthetic process0.0005360.000000001487Highly InformativeDirect
Biological Process (BP)positive regulation of angiogenesis00.0000000002027Highly InformativeDirect
Biological Process (BP)regulation of steroid biosynthetic process0.00001360.0000001939Highly InformativeDirect
Biological Process (BP)lactone biosynthetic process0.00000017470.0001357Highly InformativeDirect
Biological Process (BP)fatty acid derivative biosynthetic process0.00000000000083510.00000000003478Highly InformativeDirect
Biological Process (BP)secondary alcohol metabolic process0.000068040Highly InformativeDirect
Biological Process (BP)regulation of reactive oxygen species biosynthetic process0.00000000000012540.00000000001869Highly InformativeDirect
Biological Process (BP)negative regulation of reactive oxygen species metabolic process00.000000000000003734Highly InformativeDirect
Biological Process (BP)positive regulation of apoptotic process0.000000000013010.01672Highly InformativeInherited
Biological Process (BP)response to alcohol0.46750.09917Highly InformativeInherited
Biological Process (BP)carbohydrate homeostasis0.01060.2047Highly InformativeInherited
Biological Process (BP)response to carbohydrate0.06250.2236Highly InformativeInherited
Biological Process (BP)regulation of cellular ketone metabolic process0.014050.159Highly InformativeInherited
Biological Process (BP)unsaturated fatty acid biosynthetic process0.000000020950.1963Highly InformativeInherited
Biological Process (BP)alcohol catabolic process0.00000090690.003483Highly InformativeInherited
Molecular Function (MF)binding0.97031Least InformativeInherited
Molecular Function (MF)oxidoreductase activity00Moderately InformativeDirect
Molecular Function (MF)isomerase activity0.0000038430.1403Moderately InformativeInherited
Molecular Function (MF)metal ion binding0.55831Moderately InformativeInherited
Molecular Function (MF)intramolecular oxidoreductase activity0.0000000000000067010.00000000006805InformativeDirect
Molecular Function (MF)tetrapyrrole binding00InformativeDirect
Molecular Function (MF)monooxygenase activity00Highly InformativeDirect
Molecular Function (MF)iron ion binding0.000000110.00000001739Highly InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge00Highly InformativeDirect
Molecular Function (MF)heme binding00Highly InformativeDirect
Cellular Component (CC)membrane0.62171Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.97181Least InformativeInherited
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)endomembrane system0.00029540.00000000269Moderately InformativeDirect
Cellular Component (CC)whole membrane0.0000016071Moderately InformativeInherited
Cellular Component (CC)plasma membrane0.35491Moderately InformativeInherited
Cellular Component (CC)membrane region0.0000000000000026290.0008303InformativeDirect
Cellular Component (CC)plasma membrane region0.000000000510.00004655InformativeDirect
Cellular Component (CC)plasma membrane raft00.0000000003482Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biosynthetic process 0.00000000000005866 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0 Least Informative Direct
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.03763 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) monocarboxylic acid metabolic process 0 Moderately Informative Direct
Biological Process (BP) oxidation-reduction process 0.0001554 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.0000000001523 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.00008552 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0.00000000000004411 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 0.02993 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) animal organ development 1 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to biotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) alcohol metabolic process 0.000733 Informative Direct
Biological Process (BP) cellular aldehyde metabolic process 0.0005322 Informative Direct
Biological Process (BP) fatty acid metabolic process 0.0000000003618 Informative Direct
Biological Process (BP) isoprenoid metabolic process 0.0000000000004437 Informative Direct
Biological Process (BP) regulation of hormone levels 0 Informative Direct
Biological Process (BP) response to organic cyclic compound 0.000000002967 Informative Direct
Biological Process (BP) lipid catabolic process 0.0001334 Informative Direct
Biological Process (BP) secondary metabolic process 0 Informative Direct
Biological Process (BP) cellular ketone metabolic process 0 Informative Direct
Biological Process (BP) organic hydroxy compound biosynthetic process 0 Informative Direct
Biological Process (BP) regulation of apoptotic process 1 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) cellular response to lipid 0.2663 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 1 Informative Inherited
Biological Process (BP) inorganic ion homeostasis 0.6432 Informative Inherited
Biological Process (BP) cation homeostasis 0.8506 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.8838 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.9838 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.6035 Informative Inherited
Biological Process (BP) negative regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) negative regulation of molecular function 0.08736 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 1 Informative Inherited
Biological Process (BP) glycosyl compound metabolic process 0.1629 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.3351 Informative Inherited
Biological Process (BP) regulation of defense response 0.2226 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 1 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) central nervous system development 1 Informative Inherited
Biological Process (BP) sulfur compound biosynthetic process 0.8328 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.0528 Informative Inherited
Biological Process (BP) multi-organism reproductive process 1 Informative Inherited
Biological Process (BP) monocarboxylic acid biosynthetic process 0.001337 Informative Inherited
Biological Process (BP) system process 1 Informative Inherited
Biological Process (BP) response to hypoxia 0.0001964 Highly Informative Direct
Biological Process (BP) icosanoid metabolic process 0 Highly Informative Direct
Biological Process (BP) steroid biosynthetic process 0 Highly Informative Direct
Biological Process (BP) xenobiotic metabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of blood pressure 0.0001175 Highly Informative Direct
Biological Process (BP) isoprenoid biosynthetic process 0.00000003813 Highly Informative Direct
Biological Process (BP) phenylpropanoid metabolic process 0.00000000004216 Highly Informative Direct
Biological Process (BP) sterol metabolic process 0.00000001143 Highly Informative Direct
Biological Process (BP) antibiotic biosynthetic process 0.0000000574 Highly Informative Direct
Biological Process (BP) polyketide metabolic process 0.000002138 Highly Informative Direct
Biological Process (BP) negative regulation of defense response 0.0000008916 Highly Informative Direct
Biological Process (BP) negative regulation of response to external stimulus 0.00003751 Highly Informative Direct
Biological Process (BP) cellular hormone metabolic process 0 Highly Informative Direct
Biological Process (BP) cellular response to decreased oxygen levels 0.00000008055 Highly Informative Direct
Biological Process (BP) ketone biosynthetic process 0.00000000000002102 Highly Informative Direct
Biological Process (BP) ketone catabolic process 0.0007652 Highly Informative Direct
Biological Process (BP) hormone biosynthetic process 0 Highly Informative Direct
Biological Process (BP) response to drug 0.0002622 Highly Informative Direct
Biological Process (BP) negative regulation of sequence-specific DNA binding transcription factor activity 0.000000000004079 Highly Informative Direct
Biological Process (BP) response to estrogen 0.00001448 Highly Informative Direct
Biological Process (BP) secondary metabolite biosynthetic process 0.000000001487 Highly Informative Direct
Biological Process (BP) positive regulation of angiogenesis 0.0000000002027 Highly Informative Direct
Biological Process (BP) regulation of steroid biosynthetic process 0.0000001939 Highly Informative Direct
Biological Process (BP) lactone biosynthetic process 0.0001357 Highly Informative Direct
Biological Process (BP) fatty acid derivative biosynthetic process 0.00000000003478 Highly Informative Direct
Biological Process (BP) secondary alcohol metabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of reactive oxygen species biosynthetic process 0.00000000001869 Highly Informative Direct
Biological Process (BP) negative regulation of reactive oxygen species metabolic process 0.000000000000003734 Highly Informative Direct
Biological Process (BP) positive regulation of apoptotic process 0.01672 Highly Informative Inherited
Biological Process (BP) response to alcohol 0.09917 Highly Informative Inherited
Biological Process (BP) carbohydrate homeostasis 0.2047 Highly Informative Inherited
Biological Process (BP) response to carbohydrate 0.2236 Highly Informative Inherited
Biological Process (BP) demethylation 0.00155 Highly Informative Inherited
Biological Process (BP) regulation of cellular ketone metabolic process 0.159 Highly Informative Inherited
Biological Process (BP) unsaturated fatty acid biosynthetic process 0.1963 Highly Informative Inherited
Biological Process (BP) alcohol biosynthetic process 0.02032 Highly Informative Inherited
Biological Process (BP) fatty acid catabolic process 1 Highly Informative Inherited
Biological Process (BP) diterpenoid metabolic process 0.02315 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 1 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular component biogenesis 1 Highly Informative Inherited
Biological Process (BP) positive regulation of supramolecular fiber organization 0.06489 Highly Informative Inherited
Biological Process (BP) regulation of microtubule-based process 0.1464 Highly Informative Inherited
Biological Process (BP) regulation of protein polymerization 0.1548 Highly Informative Inherited
Biological Process (BP) multi-multicellular organism process 0.001223 Highly Informative Inherited
Biological Process (BP) alcohol catabolic process 0.003483 Highly Informative Inherited
Biological Process (BP) multicellular organismal homeostasis 0.01566 Highly Informative Inherited
Biological Process (BP) lipid modification 0.8709 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) small molecule binding 1 Moderately Informative Inherited
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) lyase activity 0.3534 Moderately Informative Inherited
Molecular Function (MF) isomerase activity 0.1403 Moderately Informative Inherited
Molecular Function (MF) metal ion binding 1 Moderately Informative Inherited
Molecular Function (MF) carbon-carbon lyase activity 0.000000002767 Informative Direct
Molecular Function (MF) intramolecular oxidoreductase activity 0.00000000006805 Informative Direct
Molecular Function (MF) tetrapyrrole binding 0 Informative Direct
Molecular Function (MF) carboxylic acid binding 0.01904 Informative Inherited
Molecular Function (MF) monooxygenase activity 0 Highly Informative Direct
Molecular Function (MF) iron ion binding 0.00000001739 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 0 Highly Informative Direct
Molecular Function (MF) aldehyde-lyase activity 0.0000000000004303 Highly Informative Direct
Molecular Function (MF) heme binding 0 Highly Informative Direct
Molecular Function (MF) monocarboxylic acid binding 0.00009337 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 1 Highly Informative Inherited
Molecular Function (MF) dioxygenase activity 1 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 1 Highly Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) endomembrane system 0.00000000269 Moderately Informative Direct
Cellular Component (CC) whole membrane 1 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 1 Moderately Informative Inherited
Cellular Component (CC) cell projection 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum membrane 0 Informative Direct
Cellular Component (CC) membrane region 0.0008303 Informative Direct
Cellular Component (CC) plasma membrane region 0.00004655 Informative Direct
Cellular Component (CC) plasma membrane bounded cell projection part 1 Informative Inherited
Cellular Component (CC) chromosome 1 Informative Inherited
Cellular Component (CC) plasma membrane raft 0.0000000003482 Highly Informative Direct
Cellular Component (CC) basal part of cell 0.00003934 Highly Informative Direct
Cellular Component (CC) basolateral plasma membrane 0.8624 Highly Informative Inherited
Cellular Component (CC) chromatin 1 Highly Informative Inherited
Cellular Component (CC) nuclear chromosome part 0.9879 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Isomerases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0Moderately InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0.7611Moderately InformativeInherited
Enzyme Commission (EC)Hydro-lyases1Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Miscellaneous (requires further characterization)1InformativeInherited
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation0.02235InformativeInherited
Enzyme Commission (EC)Other intramolecular oxidoreductases0Highly InformativeDirect
Enzyme Commission (EC)With reduced flavin or flavoprotein as one donor, 0Highly InformativeDirect
Enzyme Commission (EC)With a reduced iron-sulfur protein as one donor, a0.00000001495Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processLipid metabolism0Moderately InformativeDirect
Biological processSteroid metabolism0InformativeDirect
Biological processPlant defense0.000004573InformativeDirect
Biological processFatty acid metabolism1InformativeInherited
Biological processLipid biosynthesis1InformativeInherited
Biological processAlkaloid metabolism0Highly InformativeDirect
Biological processAntibiotic biosynthesis0Highly InformativeDirect
Biological processProstaglandin biosynthesis0Highly InformativeDirect
Biological processSteroid biosynthesis0Highly InformativeDirect
Biological processGrowth regulation0.000000001486Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentMicrosome0Highly InformativeDirect
Coding sequence diversityPolymorphism0.0000005128Moderately InformativeDirect
DomainTransmembrane0Least InformativeDirect
DomainTransit peptide0.00008804Moderately InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionIron0Moderately InformativeDirect
Molecular functionNADP0Moderately InformativeDirect
Molecular functionLipid-binding0.9849Moderately InformativeInherited
Molecular functionHeme0InformativeDirect
Molecular functionSteroid-binding0.00000001556Highly InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationMonooxygenase0Highly InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR001128 SSF48264 Protein matches
Abstract

More information about these proteins can be found at Protein of the Month: Cytochrome P450.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 23 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Cytochrome P450 domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 23 hidden Markov models representing the Cytochrome P450 superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


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