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Cytochrome P450 superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Cytochrome P450 [ 48263]
Superfamily:   Cytochrome P450 [ 48264]
Families:   Cytochrome P450 [ 48265] (22)


Superfamily statistics
Genomes (1,312) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 57,785 178,018 76
Proteins 56,382 175,261 76


Functional annotation
General category Metabolism
Detailed category Redox

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biosynthetic process0.00001180.00000000000001615Least InformativeDirect
Biological Process (BP)single-organism metabolic process00Least InformativeDirect
Biological Process (BP)organic cyclic compound metabolic process0.000087820Least InformativeDirect
Biological Process (BP)heterocycle metabolic process11Least InformativeInherited
Biological Process (BP)response to stimulus0.090481Least InformativeInherited
Biological Process (BP)single-organism cellular process0.16560.03457Least InformativeInherited
Biological Process (BP)biological regulation0.33871Least InformativeInherited
Biological Process (BP)primary metabolic process11Least InformativeInherited
Biological Process (BP)lipid metabolic process00Moderately InformativeDirect
Biological Process (BP)monocarboxylic acid metabolic process00Moderately InformativeDirect
Biological Process (BP)cellular response to chemical stimulus0.000010210.00004768Moderately InformativeDirect
Biological Process (BP)organic cyclic compound biosynthetic process0.000040210.00000000000006419Moderately InformativeDirect
Biological Process (BP)negative regulation of metabolic process0.000014021Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.0062931Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process0.40761Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.015511Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.00042031Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.86691Moderately InformativeInherited
Biological Process (BP)response to organic substance0.00066221Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.0060681Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.000037241Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.000015361Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process0.000034331Moderately InformativeInherited
Biological Process (BP)regulation of macromolecule biosynthetic process0.0021111Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.0023321Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.045430.0000000001804Moderately InformativeInherited
Biological Process (BP)regulation of cell communication0.0002231Moderately InformativeInherited
Biological Process (BP)regulation of signaling0.0002251Moderately InformativeInherited
Biological Process (BP)regulation of response to stimulus0.0040021Moderately InformativeInherited
Biological Process (BP)regulation of molecular function0.000050161Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process11Moderately InformativeInherited
Biological Process (BP)single-organism catabolic process11Moderately InformativeInherited
Biological Process (BP)small molecule biosynthetic process0.00001390.02186Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.000003661Moderately InformativeInherited
Biological Process (BP)alcohol metabolic process0.000064660.0006968InformativeDirect
Biological Process (BP)fatty acid metabolic process0.000017510.0000000003986InformativeDirect
Biological Process (BP)regulation of hormone levels0.000080770InformativeDirect
Biological Process (BP)drug metabolic process0.000000000000036910InformativeDirect
Biological Process (BP)secondary metabolic process0.00058280InformativeDirect
Biological Process (BP)monocarboxylic acid biosynthetic process0.0000000010570.0008082InformativeDirect
Biological Process (BP)fatty acid derivative metabolic process00InformativeDirect
Biological Process (BP)organic hydroxy compound biosynthetic process0.0000024870InformativeDirect
Biological Process (BP)positive regulation of developmental process0.0000000008130.9041InformativeInherited
Biological Process (BP)regulation of apoptotic process0.00000035191InformativeInherited
Biological Process (BP)positive regulation of cell death0.0000000000041270.02974InformativeInherited
Biological Process (BP)response to organic cyclic compound0.16450.000000008716InformativeInherited
Biological Process (BP)response to cytokine0.000028890.03921InformativeInherited
Biological Process (BP)cellular response to oxygen-containing compound0.95651InformativeInherited
Biological Process (BP)cellular chemical homeostasis0.61681InformativeInherited
Biological Process (BP)regulation of lipid metabolic process0.03790.05825InformativeInherited
Biological Process (BP)regulation of defense response0.000000011070.1907InformativeInherited
Biological Process (BP)regulation of response to external stimulus0.000000060280.2618InformativeInherited
Biological Process (BP)positive regulation of multicellular organismal process0.0000000086051InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis0.000023830.447InformativeInherited
Biological Process (BP)negative regulation of cellular biosynthetic process0.00000064361InformativeInherited
Biological Process (BP)regulation of transcription, DNA-templated0.00001511InformativeInherited
Biological Process (BP)negative regulation of molecular function0.00000000064380.06955InformativeInherited
Biological Process (BP)cellular ketone metabolic process0.0021870InformativeInherited
Biological Process (BP)cellular response to lipid0.87970.3004InformativeInherited
Biological Process (BP)positive regulation of signal transduction0.0000047851InformativeInherited
Biological Process (BP)negative regulation of response to stimulus0.0000000070060.8545InformativeInherited
Biological Process (BP)response to hypoxia0.00000000000046090.00006428Highly InformativeDirect
Biological Process (BP)icosanoid metabolic process0.00000000000001620Highly InformativeDirect
Biological Process (BP)steroid biosynthetic process0.00000000063810Highly InformativeDirect
Biological Process (BP)sterol metabolic process0.000024990.000000005864Highly InformativeDirect
Biological Process (BP)antibiotic biosynthetic process0.0000000000081250.0000000801Highly InformativeDirect
Biological Process (BP)polyketide metabolic process0.0000000046040.0000022Highly InformativeDirect
Biological Process (BP)negative regulation of response to external stimulus0.000000000013510.0000125Highly InformativeDirect
Biological Process (BP)cellular response to decreased oxygen levels00.00000003751Highly InformativeDirect
Biological Process (BP)ketone biosynthetic process0.00093550.00000000000002124Highly InformativeDirect
Biological Process (BP)hormone biosynthetic process0.000019940Highly InformativeDirect
Biological Process (BP)response to estrogen0.00027960.00001191Highly InformativeDirect
Biological Process (BP)secondary metabolite biosynthetic process0.00018570.000000002195Highly InformativeDirect
Biological Process (BP)positive regulation of angiogenesis00.00000000003051Highly InformativeDirect
Biological Process (BP)regulation of steroid biosynthetic process0.000012750.0000002293Highly InformativeDirect
Biological Process (BP)regulation of sequence-specific DNA binding transcription factor activity00.00006521Highly InformativeDirect
Biological Process (BP)fatty acid derivative biosynthetic process0.00000000000015280.000000000007784Highly InformativeDirect
Biological Process (BP)secondary alcohol metabolic process0.000054190Highly InformativeDirect
Biological Process (BP)regulation of reactive oxygen species biosynthetic process0.0000000000000031190.000000000001055Highly InformativeDirect
Biological Process (BP)positive regulation of apoptotic process0.0000000000011330.008701Highly InformativeInherited
Biological Process (BP)response to alcohol0.52980.1358Highly InformativeInherited
Biological Process (BP)response to carbohydrate0.065510.2401Highly InformativeInherited
Biological Process (BP)regulation of cellular ketone metabolic process0.016990.1634Highly InformativeInherited
Biological Process (BP)unsaturated fatty acid biosynthetic process0.0000000096050.1692Highly InformativeInherited
Biological Process (BP)alcohol catabolic process0.00000082740.003169Highly InformativeInherited
Molecular Function (MF)binding0.95141Least InformativeInherited
Molecular Function (MF)oxidoreductase activity00Moderately InformativeDirect
Molecular Function (MF)isomerase activity0.00000073040.0917Moderately InformativeInherited
Molecular Function (MF)metal ion binding0.7011Moderately InformativeInherited
Molecular Function (MF)intramolecular oxidoreductase activity00.00000000001576InformativeDirect
Molecular Function (MF)tetrapyrrole binding00InformativeDirect
Molecular Function (MF)monooxygenase activity00Highly InformativeDirect
Molecular Function (MF)iron ion binding0.00000013890.00000001393Highly InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge00Highly InformativeDirect
Molecular Function (MF)heme binding00Highly InformativeDirect
Cellular Component (CC)membrane0.58511Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.95761Least InformativeInherited
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)endoplasmic reticulum0.00000000017350Moderately InformativeDirect
Cellular Component (CC)plasma membrane0.28551Moderately InformativeInherited
Cellular Component (CC)whole membrane0.0000004640.9865Moderately InformativeInherited
Cellular Component (CC)membrane region00.0003606InformativeDirect
Cellular Component (CC)plasma membrane region0.000000000072450.00002021InformativeDirect
Cellular Component (CC)plasma membrane raft00.00000000009308Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biosynthetic process 0.00000000000001615 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.03457 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) monocarboxylic acid metabolic process 0 Moderately Informative Direct
Biological Process (BP) oxidation-reduction process 0.0001426 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.0000000001804 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.00004768 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0.00000000000006419 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) system development 1 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to biotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 0.02186 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) alcohol metabolic process 0.0006968 Informative Direct
Biological Process (BP) cellular aldehyde metabolic process 0.0006135 Informative Direct
Biological Process (BP) fatty acid metabolic process 0.0000000003986 Informative Direct
Biological Process (BP) isoprenoid metabolic process 0.0000000000005187 Informative Direct
Biological Process (BP) amine metabolic process 0.0009152 Informative Direct
Biological Process (BP) regulation of hormone levels 0 Informative Direct
Biological Process (BP) response to organic cyclic compound 0.000000008716 Informative Direct
Biological Process (BP) drug metabolic process 0 Informative Direct
Biological Process (BP) secondary metabolic process 0 Informative Direct
Biological Process (BP) cellular ketone metabolic process 0 Informative Direct
Biological Process (BP) monocarboxylic acid biosynthetic process 0.0008082 Informative Direct
Biological Process (BP) fatty acid derivative metabolic process 0 Informative Direct
Biological Process (BP) organic hydroxy compound biosynthetic process 0 Informative Direct
Biological Process (BP) positive regulation of developmental process 0.9041 Informative Inherited
Biological Process (BP) regulation of apoptotic process 1 Informative Inherited
Biological Process (BP) positive regulation of cell death 0.02974 Informative Inherited
Biological Process (BP) response to cytokine 0.03921 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 1 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.05825 Informative Inherited
Biological Process (BP) ion homeostasis 1 Informative Inherited
Biological Process (BP) regulation of defense response 0.1907 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.2618 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.447 Informative Inherited
Biological Process (BP) negative regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) regulation of transcription, DNA-templated 1 Informative Inherited
Biological Process (BP) negative regulation of molecular function 0.06955 Informative Inherited
Biological Process (BP) cellular lipid catabolic process 0.003926 Informative Inherited
Biological Process (BP) cellular response to lipid 0.3004 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.8545 Informative Inherited
Biological Process (BP) regulation of organelle organization 1 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 1 Informative Inherited
Biological Process (BP) central nervous system development 1 Informative Inherited
Biological Process (BP) glycosyl compound metabolic process 0.1613 Informative Inherited
Biological Process (BP) sulfur compound biosynthetic process 0.857 Informative Inherited
Biological Process (BP) system process 1 Informative Inherited
Biological Process (BP) multi-organism reproductive process 0.9879 Informative Inherited
Biological Process (BP) response to hypoxia 0.00006428 Highly Informative Direct
Biological Process (BP) renal system process 0.00001937 Highly Informative Direct
Biological Process (BP) icosanoid metabolic process 0 Highly Informative Direct
Biological Process (BP) steroid biosynthetic process 0 Highly Informative Direct
Biological Process (BP) xenobiotic metabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of blood pressure 0.0001499 Highly Informative Direct
Biological Process (BP) isoprenoid biosynthetic process 0.00000004788 Highly Informative Direct
Biological Process (BP) phenylpropanoid metabolic process 0.00000000005838 Highly Informative Direct
Biological Process (BP) sterol metabolic process 0.000000005864 Highly Informative Direct
Biological Process (BP) antibiotic biosynthetic process 0.0000000801 Highly Informative Direct
Biological Process (BP) polyketide metabolic process 0.0000022 Highly Informative Direct
Biological Process (BP) negative regulation of response to external stimulus 0.0000125 Highly Informative Direct
Biological Process (BP) cellular hormone metabolic process 0 Highly Informative Direct
Biological Process (BP) cellular response to decreased oxygen levels 0.00000003751 Highly Informative Direct
Biological Process (BP) ketone biosynthetic process 0.00000000000002124 Highly Informative Direct
Biological Process (BP) ketone catabolic process 0.0007318 Highly Informative Direct
Biological Process (BP) hormone biosynthetic process 0 Highly Informative Direct
Biological Process (BP) response to drug 0.000314 Highly Informative Direct
Biological Process (BP) response to estrogen 0.00001191 Highly Informative Direct
Biological Process (BP) secondary metabolite biosynthetic process 0.000000002195 Highly Informative Direct
Biological Process (BP) multi-multicellular organism process 0.0004514 Highly Informative Direct
Biological Process (BP) positive regulation of angiogenesis 0.00000000003051 Highly Informative Direct
Biological Process (BP) regulation of steroid biosynthetic process 0.0000002293 Highly Informative Direct
Biological Process (BP) regulation of sequence-specific DNA binding transcription factor activity 0.00006521 Highly Informative Direct
Biological Process (BP) fatty acid derivative biosynthetic process 0.000000000007784 Highly Informative Direct
Biological Process (BP) secondary alcohol metabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of reactive oxygen species biosynthetic process 0.000000000001055 Highly Informative Direct
Biological Process (BP) positive regulation of apoptotic process 0.008701 Highly Informative Inherited
Biological Process (BP) response to alcohol 0.1358 Highly Informative Inherited
Biological Process (BP) response to carbohydrate 0.2401 Highly Informative Inherited
Biological Process (BP) demethylation 0.001343 Highly Informative Inherited
Biological Process (BP) regulation of cellular ketone metabolic process 0.1634 Highly Informative Inherited
Biological Process (BP) diterpenoid metabolic process 0.02233 Highly Informative Inherited
Biological Process (BP) unsaturated fatty acid biosynthetic process 0.1692 Highly Informative Inherited
Biological Process (BP) alcohol biosynthetic process 0.01869 Highly Informative Inherited
Biological Process (BP) fatty acid catabolic process 1 Highly Informative Inherited
Biological Process (BP) regulation of protein polymerization 0.1634 Highly Informative Inherited
Biological Process (BP) regulation of microtubule-based process 0.1364 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular component biogenesis 1 Highly Informative Inherited
Biological Process (BP) positive regulation of supramolecular fiber organization 0.06666 Highly Informative Inherited
Biological Process (BP) brain development 1 Highly Informative Inherited
Biological Process (BP) alcohol catabolic process 0.003169 Highly Informative Inherited
Biological Process (BP) multicellular organismal homeostasis 0.01679 Highly Informative Inherited
Biological Process (BP) lipid modification 0.8686 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) small molecule binding 1 Moderately Informative Inherited
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) lyase activity 0.3492 Moderately Informative Inherited
Molecular Function (MF) isomerase activity 0.0917 Moderately Informative Inherited
Molecular Function (MF) metal ion binding 1 Moderately Informative Inherited
Molecular Function (MF) carbon-carbon lyase activity 0.000000002825 Informative Direct
Molecular Function (MF) intramolecular oxidoreductase activity 0.00000000001576 Informative Direct
Molecular Function (MF) tetrapyrrole binding 0 Informative Direct
Molecular Function (MF) carboxylic acid binding 0.04926 Informative Inherited
Molecular Function (MF) monooxygenase activity 0 Highly Informative Direct
Molecular Function (MF) iron ion binding 0.00000001393 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 0 Highly Informative Direct
Molecular Function (MF) aldehyde-lyase activity 0.0000000000004769 Highly Informative Direct
Molecular Function (MF) heme binding 0 Highly Informative Direct
Molecular Function (MF) monocarboxylic acid binding 0.0005014 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 1 Highly Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane 1 Moderately Informative Inherited
Cellular Component (CC) whole membrane 0.9865 Moderately Informative Inherited
Cellular Component (CC) cell projection 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum membrane 0 Informative Direct
Cellular Component (CC) membrane region 0.0003606 Informative Direct
Cellular Component (CC) plasma membrane region 0.00002021 Informative Direct
Cellular Component (CC) plasma membrane bounded cell projection part 1 Informative Inherited
Cellular Component (CC) chromosome 1 Informative Inherited
Cellular Component (CC) plasma membrane raft 0.00000000009308 Highly Informative Direct
Cellular Component (CC) basolateral plasma membrane 0.9036 Highly Informative Inherited
Cellular Component (CC) chromatin 1 Highly Informative Inherited
Cellular Component (CC) nuclear chromosome part 0.9978 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Isomerases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0Moderately InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0.7611Moderately InformativeInherited
Enzyme Commission (EC)Hydro-lyases1Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Miscellaneous (requires further characterization)1InformativeInherited
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation0.02235InformativeInherited
Enzyme Commission (EC)Other intramolecular oxidoreductases0Highly InformativeDirect
Enzyme Commission (EC)With reduced flavin or flavoprotein as one donor, 0Highly InformativeDirect
Enzyme Commission (EC)With a reduced iron-sulfur protein as one donor, a0.00000001495Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)connective tissue disease0.01323Moderately InformativeInherited
Disease Ontology (DO)endocrine system disease0.03002Moderately InformativeInherited
Disease Ontology (DO)physical disorder0.05306InformativeInherited
Disease Ontology (DO)hypospadias0.0001266Highly InformativeDirect
Disease Ontology (DO)hyperandrogenism0.0002441Highly InformativeDirect
Disease Ontology (DO)bone remodeling disease0.0009441Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Neonatal onset0.0004933InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.2069Moderately InformativeInherited
Phenotypic Abnormality (PA)Hyperaldosteronism0.00005561Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.2342Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.7959Least InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.0008485Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.1995Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.2636Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal systemic arterial blood pressure0.00007087InformativeDirect
Mammalian Phenotype (MP)abnormal circulating lipid level0.05477InformativeInherited
Mammalian Phenotype (MP)abnormal xenobiotic pharmacokinetics0.00000748Highly InformativeDirect
Mammalian Phenotype (MP)abnormal fat-soluble vitamin level0.0004777Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism behavior variant0Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.2467Least InformativeInherited
Worm Phenotype (WP)defecation variant0InformativeDirect
Worm Phenotype (WP)metal response variant0.0001659InformativeDirect
Worm Phenotype (WP)defecation cycle variant0Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)integumentary system0.002849Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.1748Least InformativeInherited
Fly Anatomy (FA)anatomical group0.1949Least InformativeInherited
Fly Anatomy (FA)somatic cell0.3696Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.4192Least InformativeInherited
Fly Anatomy (FA)larva0.4974Least InformativeInherited
Fly Anatomy (FA)nervous system0.5533Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)epithelium0.01222Moderately InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.02094Moderately InformativeInherited
Fly Anatomy (FA)ganglion0.1214Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.1483Moderately InformativeInherited
Fly Anatomy (FA)developing material anatomical entity0.4425Moderately InformativeInherited
Fly Anatomy (FA)late embryo0.4826Moderately InformativeInherited
Fly Anatomy (FA)cuboidal/columnar epithelium0.0001171InformativeDirect
Fly Anatomy (FA)presumptive embryonic/larval nervous system0.000139InformativeDirect
Fly Anatomy (FA)digestive system0.001612InformativeInherited
Fly Anatomy (FA)ventral nerve cord0.01513InformativeInherited
Fly Anatomy (FA)primordium0.029InformativeInherited
Fly Anatomy (FA)hindgut0.000003704Highly InformativeDirect
Fly Anatomy (FA)commissure0.000006635Highly InformativeDirect
Fly Anatomy (FA)neuropil glial sheath0.000008222Highly InformativeDirect
Fly Anatomy (FA)presumptive embryonic/larval central nervous system0.00002224Highly InformativeDirect
Fly Anatomy (FA)midgut primordium0.000103Highly InformativeDirect
Fly Anatomy (FA)CNS glial cell0.0004049Highly InformativeDirect
Fly Anatomy (FA)embryonic head0.0005062Highly InformativeDirect
Fly Anatomy (FA)embryonic epidermis0.4271Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)fruit0.01271InformativeInherited

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on the CH-OH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases1Moderately InformativeInherited
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0.7705InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1InformativeInherited
Enzyme Commission (EC)Acting on single donors with incorporation of molecular oxygen (oxygenases). The oxygen incorporated1InformativeInherited
Enzyme Commission (EC)Acting on NADH or NADPH1InformativeInherited
Enzyme Commission (EC)Intramolecular transferases1InformativeInherited
Enzyme Commission (EC)With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen0Highly InformativeDirect
Enzyme Commission (EC)Other intramolecular oxidoreductases0Highly InformativeDirect
Enzyme Commission (EC)With a heme protein as acceptor0.0000005349Highly InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation of one atom of oxygen0.004738Highly InformativeInherited
Enzyme Commission (EC)With incorporation of two atoms of oxygen0.02524Highly InformativeInherited
Enzyme Commission (EC)With another compound as one donor, and incorporation of one atom of oxygen1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processLipid metabolism0Moderately InformativeDirect
Biological processSteroid metabolism0InformativeDirect
Biological processPlant defense0.000002193InformativeDirect
Biological processFatty acid metabolism1InformativeInherited
Biological processLipid biosynthesis1InformativeInherited
Biological processAlkaloid metabolism0Highly InformativeDirect
Biological processAntibiotic biosynthesis0Highly InformativeDirect
Biological processProstaglandin biosynthesis0Highly InformativeDirect
Biological processSteroid biosynthesis0Highly InformativeDirect
Biological processGrowth regulation0.000000001179Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentMicrosome0Highly InformativeDirect
Coding sequence diversityPolymorphism0.0000007378Moderately InformativeDirect
DomainTransmembrane0Least InformativeDirect
DomainTransit peptide0.00003704Moderately InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionIron0Moderately InformativeDirect
Molecular functionNADP0Moderately InformativeDirect
Molecular functionLipid-binding0.9591Moderately InformativeInherited
Molecular functionHeme0InformativeDirect
Molecular functionSteroid-binding0.00000001377Highly InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationMonooxygenase0Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)lipid metabolism0Least InformativeDirect
UniPathway (UP)aromatic compound metabolism1Least InformativeInherited
UniPathway (UP)antibiotic biosynthesis0Moderately InformativeDirect
UniPathway (UP)secondary metabolite metabolism0Moderately InformativeDirect
UniPathway (UP)alcohol metabolism0Moderately InformativeDirect
UniPathway (UP)aromatic compound biosynthesis0.00000001503Moderately InformativeDirect
UniPathway (UP)nitrogen metabolism0.00000001515Moderately InformativeDirect
UniPathway (UP)fatty acid metabolism1Moderately InformativeInherited
UniPathway (UP)lipid biosynthesis1Moderately InformativeInherited
UniPathway (UP)alkaloid metabolism0InformativeDirect
UniPathway (UP)toxin biosynthesis0InformativeDirect
UniPathway (UP)steroid metabolism0InformativeDirect
UniPathway (UP)alcohol biosynthesis0InformativeDirect
UniPathway (UP)phenylpropanoid biosynthesis0InformativeDirect
UniPathway (UP)pigment biosynthesis0.0007954InformativeDirect
UniPathway (UP)hormone biosynthesis0.0105InformativeInherited
UniPathway (UP)terpene biosynthesis0.02005InformativeInherited
UniPathway (UP)plant hormone metabolism0.1642InformativeInherited
UniPathway (UP)flavonoid metabolism0.9983InformativeInherited
UniPathway (UP)mycotoxin biosynthesis0Highly InformativeDirect
UniPathway (UP)cholesterol degradation0.000000000003954Highly InformativeDirect
UniPathway (UP)oxylipin biosynthesis0.00000000006311Highly InformativeDirect
UniPathway (UP)sterol biosynthesis0.0008654Highly InformativeDirect
UniPathway (UP)erythromycin biosynthesis0.0009713Highly InformativeDirect
UniPathway (UP)steroid hormone biosynthesis0.1258Highly InformativeInherited
UniPathway (UP)monoterpene metabolism0.6075Highly InformativeInherited
UniPathway (UP)plant hormone biosynthesis0.6118Highly InformativeInherited
UniPathway (UP)flavonoid biosynthesis1Highly InformativeInherited

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR001128 SSF48264 Protein matches
Abstract

More information about these proteins can be found at Protein of the Month: Cytochrome P450.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 23 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Cytochrome P450 domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 23 hidden Markov models representing the Cytochrome P450 superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]