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Cytochrome P450 superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Cytochrome P450 [ 48263]
Superfamily:   Cytochrome P450 [ 48264]
Families:   Cytochrome P450 [ 48265] (22)


Superfamily statistics
Genomes (1,308) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 57,465 77,510 76
Proteins 56,095 76,848 76


Functional annotation
General category Metabolism
Detailed category Redox

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biosynthetic process0.000054010.000000000002876Least InformativeDirect
Biological Process (BP)single-organism metabolic process00Least InformativeDirect
Biological Process (BP)organic cyclic compound metabolic process0.00001220Least InformativeDirect
Biological Process (BP)biological regulation0.44711Least InformativeInherited
Biological Process (BP)heterocycle metabolic process11Least InformativeInherited
Biological Process (BP)single-organism cellular process0.6790.9598Least InformativeInherited
Biological Process (BP)response to stimulus0.050611Least InformativeInherited
Biological Process (BP)primary metabolic process11Least InformativeInherited
Biological Process (BP)lipid metabolic process00Moderately InformativeDirect
Biological Process (BP)monocarboxylic acid metabolic process00Moderately InformativeDirect
Biological Process (BP)cellular response to chemical stimulus0.0000032720.000004644Moderately InformativeDirect
Biological Process (BP)negative regulation of cellular process0.011071Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process0.0000099161Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.000013091Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.024331Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.0000035520.9614Moderately InformativeInherited
Biological Process (BP)response to stress0.53441Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.93141Moderately InformativeInherited
Biological Process (BP)response to organic substance0.0013191Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.00076361Moderately InformativeInherited
Biological Process (BP)regulation of response to stimulus0.009081Moderately InformativeInherited
Biological Process (BP)small molecule biosynthetic process0.0000077510.02402Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.0001271Moderately InformativeInherited
Biological Process (BP)regulation of biosynthetic process0.0000043571Moderately InformativeInherited
Biological Process (BP)regulation of cellular metabolic process0.002971Moderately InformativeInherited
Biological Process (BP)regulation of nitrogen compound metabolic process0.013441Moderately InformativeInherited
Biological Process (BP)regulation of molecular function0.000039151Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.11660.00000000679Moderately InformativeInherited
Biological Process (BP)regulation of cell communication0.00067541Moderately InformativeInherited
Biological Process (BP)regulation of signaling0.00064261Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative biosynthetic process11Moderately InformativeInherited
Biological Process (BP)glycosyl compound metabolic process0.98561Moderately InformativeInherited
Biological Process (BP)single-organism catabolic process11Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process11Moderately InformativeInherited
Biological Process (BP)alcohol metabolic process0.000120.0005247InformativeDirect
Biological Process (BP)fatty acid metabolic process0.00001340.0000000004827InformativeDirect
Biological Process (BP)regulation of hormone levels0.00018250InformativeDirect
Biological Process (BP)drug metabolic process0.00000000000042990InformativeDirect
Biological Process (BP)organic hydroxy compound biosynthetic process0.0000021120InformativeDirect
Biological Process (BP)negative regulation of nitrogen compound metabolic process0.000000028251InformativeInherited
Biological Process (BP)regulation of lipid metabolic process0.045220.1997InformativeInherited
Biological Process (BP)positive regulation of developmental process0.00000000070830.8552InformativeInherited
Biological Process (BP)positive regulation of multicellular organismal process0.000000056091InformativeInherited
Biological Process (BP)regulation of apoptotic process0.00000036011InformativeInherited
Biological Process (BP)positive regulation of cell death0.0000000000030380.02526InformativeInherited
Biological Process (BP)cellular response to oxygen-containing compound0.99671InformativeInherited
Biological Process (BP)response to organic cyclic compound0.15160.000000009402InformativeInherited
Biological Process (BP)cellular response to lipid0.88240.2575InformativeInherited
Biological Process (BP)response to cytokine0.000015030.02072InformativeInherited
Biological Process (BP)regulation of defense response0.000000001770.1397InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis0.000044740.4968InformativeInherited
Biological Process (BP)negative regulation of biosynthetic process0.0000001061InformativeInherited
Biological Process (BP)positive regulation of signal transduction0.00000021311InformativeInherited
Biological Process (BP)regulation of response to external stimulus0.0000000025480.2489InformativeInherited
Biological Process (BP)regulation of transcription, DNA-templated0.0000055161InformativeInherited
Biological Process (BP)negative regulation of molecular function0.00000000043450.06112InformativeInherited
Biological Process (BP)negative regulation of response to stimulus0.000000041410.9896InformativeInherited
Biological Process (BP)secondary metabolic process0.0014480InformativeInherited
Biological Process (BP)glycosyl compound biosynthetic process0.30740.3855InformativeInherited
Biological Process (BP)isoprenoid metabolic process0.45330.000000000003139InformativeInherited
Biological Process (BP)lipid catabolic process0.03490.0001039InformativeInherited
Biological Process (BP)monocarboxylic acid biosynthetic process0.0000000013260.003029InformativeInherited
Biological Process (BP)cellular chemical homeostasis0.57541InformativeInherited
Biological Process (BP)response to hypoxia0.00000000000012920.00004133Highly InformativeDirect
Biological Process (BP)icosanoid metabolic process0.000000000000083380Highly InformativeDirect
Biological Process (BP)steroid metabolic process00Highly InformativeDirect
Biological Process (BP)glycoside metabolic process0.000035220.00000566Highly InformativeDirect
Biological Process (BP)antibiotic biosynthetic process0.000000000062150.0000004066Highly InformativeDirect
Biological Process (BP)polyketide metabolic process0.0000000036480.000002429Highly InformativeDirect
Biological Process (BP)negative regulation of response to external stimulus0.0000000000000015570.00003647Highly InformativeDirect
Biological Process (BP)hormone biosynthetic process0.000013220Highly InformativeDirect
Biological Process (BP)response to estrogen0.00035320.00001379Highly InformativeDirect
Biological Process (BP)positive regulation of angiogenesis00.00000000002362Highly InformativeDirect
Biological Process (BP)regulation of inflammatory response0.00000000000011160.00001197Highly InformativeDirect
Biological Process (BP)regulation of steroid biosynthetic process0.00001030.0000005102Highly InformativeDirect
Biological Process (BP)regulation of sequence-specific DNA binding transcription factor activity00.00004133Highly InformativeDirect
Biological Process (BP)lipid homeostasis0.000000035480.000002919Highly InformativeDirect
Biological Process (BP)fatty acid derivative biosynthetic process0.000000000000011570.00000000000001746Highly InformativeDirect
Biological Process (BP)secondary alcohol metabolic process0.0000170Highly InformativeDirect
Biological Process (BP)regulation of reactive oxygen species biosynthetic process0.0000000000000030420.000000000000848Highly InformativeDirect
Biological Process (BP)positive regulation of apoptotic process0.00000000000084050.008347Highly InformativeInherited
Biological Process (BP)response to alcohol0.52860.1748Highly InformativeInherited
Biological Process (BP)response to carbohydrate0.070670.2477Highly InformativeInherited
Biological Process (BP)regulation of cellular ketone metabolic process0.022090.1514Highly InformativeInherited
Biological Process (BP)unsaturated fatty acid biosynthetic process0.00000014470.5625Highly InformativeInherited
Biological Process (BP)alcohol catabolic process0.00000020470.001016Highly InformativeInherited
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)oxidoreductase activity00Moderately InformativeDirect
Molecular Function (MF)isomerase activity0.0000025680.1301Moderately InformativeInherited
Molecular Function (MF)metal ion binding0.74641Moderately InformativeInherited
Molecular Function (MF)intramolecular oxidoreductase activity0.0000000000000072270.0000000001044InformativeDirect
Molecular Function (MF)tetrapyrrole binding00InformativeDirect
Molecular Function (MF)monooxygenase activity00Highly InformativeDirect
Molecular Function (MF)iron ion binding0.00000067060.00000007415Highly InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge00Highly InformativeDirect
Molecular Function (MF)heme binding00Highly InformativeDirect
Cellular Component (CC)membrane0.57061Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.88841Least InformativeInherited
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)endoplasmic reticulum0.000000000082010Moderately InformativeDirect
Cellular Component (CC)whole membrane0.00000020850.92Moderately InformativeInherited
Cellular Component (CC)plasma membrane0.26111Moderately InformativeInherited
Cellular Component (CC)membrane region00.000256InformativeDirect
Cellular Component (CC)plasma membrane region0.000000000062330.00001328InformativeDirect
Cellular Component (CC)membrane raft11Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biosynthetic process 0.000000000002876 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0 Least Informative Direct
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.9598 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) monocarboxylic acid metabolic process 0 Moderately Informative Direct
Biological Process (BP) oxidation-reduction process 0.00007645 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.00000000679 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.000004644 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.9614 Moderately Informative Inherited
Biological Process (BP) response to stress 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 0.02402 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.9453 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) system development 1 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.9435 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) glycosyl compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) alcohol metabolic process 0.0005247 Informative Direct
Biological Process (BP) fatty acid metabolic process 0.0000000004827 Informative Direct
Biological Process (BP) isoprenoid metabolic process 0.000000000003139 Informative Direct
Biological Process (BP) amine metabolic process 0.0007741 Informative Direct
Biological Process (BP) regulation of hormone levels 0 Informative Direct
Biological Process (BP) response to organic cyclic compound 0.000000009402 Informative Direct
Biological Process (BP) lipid catabolic process 0.0001039 Informative Direct
Biological Process (BP) drug metabolic process 0 Informative Direct
Biological Process (BP) secondary metabolic process 0 Informative Direct
Biological Process (BP) cellular ketone metabolic process 0 Informative Direct
Biological Process (BP) organic hydroxy compound biosynthetic process 0 Informative Direct
Biological Process (BP) negative regulation of nitrogen compound metabolic process 1 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.1997 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.8552 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) regulation of apoptotic process 1 Informative Inherited
Biological Process (BP) positive regulation of cell death 0.02526 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) cellular response to lipid 0.2575 Informative Inherited
Biological Process (BP) response to cytokine 0.02072 Informative Inherited
Biological Process (BP) ion homeostasis 1 Informative Inherited
Biological Process (BP) regulation of defense response 0.1397 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) cellular aldehyde metabolic process 0.001258 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.4968 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 1 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.2489 Informative Inherited
Biological Process (BP) regulation of transcription, DNA-templated 1 Informative Inherited
Biological Process (BP) negative regulation of molecular function 0.06112 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.9896 Informative Inherited
Biological Process (BP) regulation of organelle organization 1 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 1 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) central nervous system development 1 Informative Inherited
Biological Process (BP) glycosyl compound biosynthetic process 0.3855 Informative Inherited
Biological Process (BP) sulfur compound biosynthetic process 0.6925 Informative Inherited
Biological Process (BP) multi-organism reproductive process 1 Informative Inherited
Biological Process (BP) monocarboxylic acid biosynthetic process 0.003029 Informative Inherited
Biological Process (BP) system process 1 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 1 Informative Inherited
Biological Process (BP) response to hypoxia 0.00004133 Highly Informative Direct
Biological Process (BP) renal system process 0.000009009 Highly Informative Direct
Biological Process (BP) icosanoid metabolic process 0 Highly Informative Direct
Biological Process (BP) steroid metabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of blood pressure 0.0001071 Highly Informative Direct
Biological Process (BP) isoprenoid biosynthetic process 0.0000003506 Highly Informative Direct
Biological Process (BP) phenylpropanoid metabolic process 0.000000000009331 Highly Informative Direct
Biological Process (BP) glycoside metabolic process 0.00000566 Highly Informative Direct
Biological Process (BP) antibiotic biosynthetic process 0.0000004066 Highly Informative Direct
Biological Process (BP) polyketide metabolic process 0.000002429 Highly Informative Direct
Biological Process (BP) negative regulation of response to external stimulus 0.00003647 Highly Informative Direct
Biological Process (BP) cellular hormone metabolic process 0 Highly Informative Direct
Biological Process (BP) ketone biosynthetic process 0.0000000000002889 Highly Informative Direct
Biological Process (BP) ketone catabolic process 0.0007618 Highly Informative Direct
Biological Process (BP) hormone biosynthetic process 0 Highly Informative Direct
Biological Process (BP) response to estrogen 0.00001379 Highly Informative Direct
Biological Process (BP) positive regulation of angiogenesis 0.00000000002362 Highly Informative Direct
Biological Process (BP) regulation of inflammatory response 0.00001197 Highly Informative Direct
Biological Process (BP) regulation of steroid biosynthetic process 0.0000005102 Highly Informative Direct
Biological Process (BP) regulation of sequence-specific DNA binding transcription factor activity 0.00004133 Highly Informative Direct
Biological Process (BP) lipid homeostasis 0.000002919 Highly Informative Direct
Biological Process (BP) cellular response to xenobiotic stimulus 0 Highly Informative Direct
Biological Process (BP) fatty acid derivative biosynthetic process 0.00000000000001746 Highly Informative Direct
Biological Process (BP) secondary alcohol metabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of reactive oxygen species biosynthetic process 0.000000000000848 Highly Informative Direct
Biological Process (BP) positive regulation of apoptotic process 0.008347 Highly Informative Inherited
Biological Process (BP) response to alcohol 0.1748 Highly Informative Inherited
Biological Process (BP) response to carbohydrate 0.2477 Highly Informative Inherited
Biological Process (BP) demethylation 0.001102 Highly Informative Inherited
Biological Process (BP) regulation of cellular ketone metabolic process 0.1514 Highly Informative Inherited
Biological Process (BP) multicellular organismal homeostasis 0.01135 Highly Informative Inherited
Biological Process (BP) unsaturated fatty acid biosynthetic process 0.5625 Highly Informative Inherited
Biological Process (BP) alcohol biosynthetic process 0.01601 Highly Informative Inherited
Biological Process (BP) response to drug 0.001051 Highly Informative Inherited
Biological Process (BP) fatty acid catabolic process 1 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.8991 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular component biogenesis 0.9471 Highly Informative Inherited
Biological Process (BP) brain development 1 Highly Informative Inherited
Biological Process (BP) diterpenoid metabolic process 0.02853 Highly Informative Inherited
Biological Process (BP) multi-multicellular organism process 0.001211 Highly Informative Inherited
Biological Process (BP) alcohol catabolic process 0.001016 Highly Informative Inherited
Biological Process (BP) lipid modification 0.9311 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) lyase activity 0.3996 Moderately Informative Inherited
Molecular Function (MF) isomerase activity 0.1301 Moderately Informative Inherited
Molecular Function (MF) metal ion binding 1 Moderately Informative Inherited
Molecular Function (MF) carbon-carbon lyase activity 0.000000006097 Informative Direct
Molecular Function (MF) intramolecular oxidoreductase activity 0.0000000001044 Informative Direct
Molecular Function (MF) tetrapyrrole binding 0 Informative Direct
Molecular Function (MF) monooxygenase activity 0 Highly Informative Direct
Molecular Function (MF) iron ion binding 0.00000007415 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 0 Highly Informative Direct
Molecular Function (MF) aldehyde-lyase activity 0.00000000000001624 Highly Informative Direct
Molecular Function (MF) heme binding 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 1 Highly Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0 Moderately Informative Direct
Cellular Component (CC) whole membrane 0.92 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 1 Moderately Informative Inherited
Cellular Component (CC) cell projection 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum membrane 0 Informative Direct
Cellular Component (CC) membrane region 0.000256 Informative Direct
Cellular Component (CC) plasma membrane region 0.00001328 Informative Direct
Cellular Component (CC) cell projection part 1 Informative Inherited
Cellular Component (CC) chromosome 1 Informative Inherited
Cellular Component (CC) basolateral plasma membrane 0.07102 Highly Informative Inherited
Cellular Component (CC) membrane raft 1 Highly Informative Inherited
Cellular Component (CC) nuclear chromosome 1 Highly Informative Inherited
Cellular Component (CC) chromatin 0.991 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Isomerases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0Moderately InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0.7611Moderately InformativeInherited
Enzyme Commission (EC)Hydro-lyases1Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Miscellaneous (requires further characterization)1InformativeInherited
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation0.02235InformativeInherited
Enzyme Commission (EC)Other intramolecular oxidoreductases0Highly InformativeDirect
Enzyme Commission (EC)With reduced flavin or flavoprotein as one donor, 0Highly InformativeDirect
Enzyme Commission (EC)With a reduced iron-sulfur protein as one donor, a0.00000001495Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)connective tissue disease0.0129Moderately InformativeInherited
Disease Ontology (DO)endocrine system disease0.02272Moderately InformativeInherited
Disease Ontology (DO)physical disorder0.05348InformativeInherited
Disease Ontology (DO)hypospadias0.0001305Highly InformativeDirect
Disease Ontology (DO)hyperandrogenism0.0002157Highly InformativeDirect
Disease Ontology (DO)bone remodeling disease0.0009093Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Neonatal onset0.0005323InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.207Moderately InformativeInherited
Phenotypic Abnormality (PA)Hyperaldosteronism0.00005737Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.2326Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.8809Least InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.004842Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.09482Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.3457Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal systemic arterial blood pressure0.000225InformativeDirect
Mammalian Phenotype (MP)abnormal xenobiotic pharmacokinetics0.000009184Highly InformativeDirect
Mammalian Phenotype (MP)abnormal fat-soluble vitamin level0.0004961Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism behavior variant0Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.1898Least InformativeInherited
Worm Phenotype (WP)defecation variant0InformativeDirect
Worm Phenotype (WP)metal response variant0.0001223InformativeDirect
Worm Phenotype (WP)defecation cycle variant0Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)integumentary system0.006025Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.05882Least InformativeInherited
Fly Anatomy (FA)anatomical group0.09888Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.268Least InformativeInherited
Fly Anatomy (FA)nervous system0.3826Least InformativeInherited
Fly Anatomy (FA)cell0.574Least InformativeInherited
Fly Anatomy (FA)larva0.6013Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)acellular anatomical structure0.002748Moderately InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.01069Moderately InformativeInherited
Fly Anatomy (FA)ganglion0.07744Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.132Moderately InformativeInherited
Fly Anatomy (FA)portion of tissue0.2289Moderately InformativeInherited
Fly Anatomy (FA)developing material anatomical entity0.3322Moderately InformativeInherited
Fly Anatomy (FA)late embryo0.5335Moderately InformativeInherited
Fly Anatomy (FA)tract0.0000432InformativeDirect
Fly Anatomy (FA)digestive system0.0004705InformativeDirect
Fly Anatomy (FA)embryonic/larval integumentary system0.005873InformativeInherited
Fly Anatomy (FA)presumptive embryonic/larval system0.005903InformativeInherited
Fly Anatomy (FA)primordium0.01988InformativeInherited
Fly Anatomy (FA)embryonic/larval central nervous system0.1288InformativeInherited
Fly Anatomy (FA)hindgut0.000001478Highly InformativeDirect
Fly Anatomy (FA)neuropil glial sheath0.000004405Highly InformativeDirect
Fly Anatomy (FA)presumptive embryonic/larval central nervous system0.000006208Highly InformativeDirect
Fly Anatomy (FA)midgut primordium0.00005899Highly InformativeDirect
Fly Anatomy (FA)embryonic epidermis0.00009735Highly InformativeDirect
Fly Anatomy (FA)embryonic head0.0002901Highly InformativeDirect
Fly Anatomy (FA)CNS glial cell0.0005171Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)fruit0.01271InformativeInherited

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on the CH-OH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases1Moderately InformativeInherited
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0.8768InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1InformativeInherited
Enzyme Commission (EC)Acting on single donors with incorporation of molecular oxygen (oxygenases). The oxygen incorporated1InformativeInherited
Enzyme Commission (EC)Acting on NADH or NADPH1InformativeInherited
Enzyme Commission (EC)Intramolecular transferases1InformativeInherited
Enzyme Commission (EC)With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen0Highly InformativeDirect
Enzyme Commission (EC)Other intramolecular oxidoreductases0Highly InformativeDirect
Enzyme Commission (EC)Transferring hydroxy groups0.00000004109Highly InformativeDirect
Enzyme Commission (EC)With a heme protein as acceptor0.0000005023Highly InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation of one atom of oxygen0.003388Highly InformativeInherited
Enzyme Commission (EC)With incorporation of two atoms of oxygen0.02429Highly InformativeInherited
Enzyme Commission (EC)With another compound as one donor, and incorporation of one atom of oxygen1Highly InformativeInherited

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)antiinfectives for systemic use0.0008882Least InformativeDirect
Drugbank ATC_code (DB)antineoplastic and immunomodulating agents0.453Least InformativeInherited
Drugbank ATC_code (DB)nervous system0.569Least InformativeInherited
Drugbank ATC_code (DB)genito urinary system and sex hormones0.01305Moderately InformativeInherited
Drugbank ATC_code (DB)dermatologicals0.07931Moderately InformativeInherited
Drugbank ATC_code (DB)psycholeptics0.08772Moderately InformativeInherited
Drugbank ATC_code (DB)drugs for treatment of tuberculosis0.000002796InformativeDirect
Drugbank ATC_code (DB)hormone antagonists and related agents0.0002532InformativeDirect
Drugbank ATC_code (DB)ketoconazole0.000001751Highly InformativeDirect
Drugbank ATC_code (DB)paliperidone0.0003088Highly InformativeDirect
Drugbank ATC_code (DB)hydrazides0.0005315Highly InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processLipid metabolism0Moderately InformativeDirect
Biological processSteroid metabolism0InformativeDirect
Biological processPlant defense0.000001302InformativeDirect
Biological processFatty acid metabolism1InformativeInherited
Biological processLipid biosynthesis1InformativeInherited
Biological processAntibiotic biosynthesis0Highly InformativeDirect
Biological processProstaglandin biosynthesis0Highly InformativeDirect
Biological processSteroid biosynthesis0Highly InformativeDirect
Biological processGrowth regulation0.0000000007403Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentMicrosome0Highly InformativeDirect
Coding sequence diversityPolymorphism0.000001398Moderately InformativeDirect
DomainTransmembrane0Least InformativeDirect
DomainTransit peptide0.00004906Moderately InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionIron0Moderately InformativeDirect
Molecular functionLipid-binding0.5879Moderately InformativeInherited
Molecular functionHeme0InformativeDirect
Molecular functionNADP0InformativeDirect
Molecular functionSteroid-binding0.00000001174Highly InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationMonooxygenase0Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)lipid metabolism0Least InformativeDirect
UniPathway (UP)aromatic compound metabolism1Least InformativeInherited
UniPathway (UP)antibiotic biosynthesis0Moderately InformativeDirect
UniPathway (UP)secondary metabolite metabolism0Moderately InformativeDirect
UniPathway (UP)alcohol metabolism0Moderately InformativeDirect
UniPathway (UP)aromatic compound biosynthesis0.000000004623Moderately InformativeDirect
UniPathway (UP)nitrogen metabolism0.000000848Moderately InformativeDirect
UniPathway (UP)fatty acid metabolism1Moderately InformativeInherited
UniPathway (UP)lipid biosynthesis1Moderately InformativeInherited
UniPathway (UP)alkaloid metabolism0InformativeDirect
UniPathway (UP)toxin biosynthesis0InformativeDirect
UniPathway (UP)steroid metabolism0InformativeDirect
UniPathway (UP)alcohol biosynthesis0InformativeDirect
UniPathway (UP)phenylpropanoid biosynthesis0InformativeDirect
UniPathway (UP)terpene biosynthesis0.0002639InformativeDirect
UniPathway (UP)pigment biosynthesis0.000533InformativeDirect
UniPathway (UP)hormone biosynthesis0.02285InformativeInherited
UniPathway (UP)plant hormone metabolism0.2668InformativeInherited
UniPathway (UP)flavonoid metabolism0.9983InformativeInherited
UniPathway (UP)mycotoxin biosynthesis0Highly InformativeDirect
UniPathway (UP)oxylipin biosynthesis0.00000000006302Highly InformativeDirect
UniPathway (UP)sterol biosynthesis0.0006225Highly InformativeDirect
UniPathway (UP)erythromycin biosynthesis0.0009701Highly InformativeDirect
UniPathway (UP)steroid hormone biosynthesis0.2717Highly InformativeInherited
UniPathway (UP)monoterpene metabolism0.5256Highly InformativeInherited
UniPathway (UP)plant hormone biosynthesis0.7967Highly InformativeInherited
UniPathway (UP)flavonoid biosynthesis1Highly InformativeInherited

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR001128 SSF48264 Protein matches
Abstract

More information about these proteins can be found at Protein of the Month: Cytochrome P450.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 23 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Cytochrome P450 domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 23 hidden Markov models representing the Cytochrome P450 superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]