SUPERFAMILY 1.75 HMM library and genome assignments server


Cytochrome P450 superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Cytochrome P450 [ 48263]
Superfamily:   Cytochrome P450 [ 48264]
Families:   Cytochrome P450 [ 48265] (22)


Superfamily statistics
Genomes (1,256) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 48,301 51,241 76
Proteins 47,586 50,837 76


Functional annotation
General category Metabolism
Detailed category Redox

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biosynthetic process8.337e-120Least InformativeDirect
Biological Process (BP)single-organism metabolic process4.853e-110Least InformativeDirect
Biological Process (BP)heterocycle metabolic process11Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)response to stimulus0.18411Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.12191Least InformativeInherited
Biological Process (BP)regulation of cellular process0.95561Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.0017650Least InformativeInherited
Biological Process (BP)lipid biosynthetic process8.136e-120Moderately InformativeDirect
Biological Process (BP)monocarboxylic acid metabolic process4.852e-110Moderately InformativeDirect
Biological Process (BP)cellular lipid metabolic process2.21e-060Moderately InformativeDirect
Biological Process (BP)single-organism biosynthetic process00Moderately InformativeDirect
Biological Process (BP)cellular response to chemical stimulus4.676e-073.524e-08Moderately InformativeDirect
Biological Process (BP)organic cyclic compound biosynthetic process1.367e-060Moderately InformativeDirect
Biological Process (BP)organic hydroxy compound metabolic process8.096e-110Moderately InformativeDirect
Biological Process (BP)regulation of developmental process2.212e-051Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process0.13540.3135Moderately InformativeInherited
Biological Process (BP)regulation of programmed cell death8.312e-061Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.023031Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.0021951Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus7.727e-070.7865Moderately InformativeInherited
Biological Process (BP)response to organic substance0.0098941Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound11Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.00034561Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process1.771e-051Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.0351Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.0019711Moderately InformativeInherited
Biological Process (BP)regulation of macromolecule biosynthetic process0.007011Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.016541Moderately InformativeInherited
Biological Process (BP)positive regulation of response to stimulus7.22e-051Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.00032111Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process4.025e-051Moderately InformativeInherited
Biological Process (BP)organic cyclic compound catabolic process0.044420.9271Moderately InformativeInherited
Biological Process (BP)homeostatic process0.43291Moderately InformativeInherited
Biological Process (BP)alcohol metabolic process5.345e-100InformativeDirect
Biological Process (BP)steroid metabolic process00InformativeDirect
Biological Process (BP)regulation of hormone levels2.549e-060InformativeDirect
Biological Process (BP)regulation of response to external stimulus3.515e-100.0008845InformativeDirect
Biological Process (BP)monocarboxylic acid biosynthetic process1.697e-112.905e-05InformativeDirect
Biological Process (BP)response to cytokine stimulus6.769e-070.04604InformativeInherited
Biological Process (BP)cellular chemical homeostasis0.68161InformativeInherited
Biological Process (BP)cellular response to oxygen-containing compound0.95921InformativeInherited
Biological Process (BP)response to lipid0.94320.03751InformativeInherited
Biological Process (BP)response to organic cyclic compound0.75653.052e-06InformativeInherited
Biological Process (BP)fatty acid metabolic process0.0033181.398e-09InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis4.557e-050.9437InformativeInherited
Biological Process (BP)positive regulation of developmental process2.045e-100.645InformativeInherited
Biological Process (BP)negative regulation of biosynthetic process3.44e-071InformativeInherited
Biological Process (BP)negative regulation of nitrogen compound metabolic process8.162e-101InformativeInherited
Biological Process (BP)organic hydroxy compound biosynthetic process0.049113.443e-14InformativeInherited
Biological Process (BP)positive regulation of signal transduction1.621e-071InformativeInherited
Biological Process (BP)regulation of defense response1.094e-090.08691InformativeInherited
Biological Process (BP)negative regulation of response to stimulus4.313e-080.6683InformativeInherited
Biological Process (BP)secondary metabolic process0.013333.746e-15InformativeInherited
Biological Process (BP)regulation of lipid metabolic process0.053030.1858InformativeInherited
Biological Process (BP)glycosyl compound biosynthetic process0.18060.0121InformativeInherited
Biological Process (BP)vitamin metabolic process0.31637.003e-12InformativeInherited
Biological Process (BP)isoprenoid metabolic process0.21356.861e-09InformativeInherited
Biological Process (BP)lipid catabolic process0.01181.732e-05InformativeInherited
Biological Process (BP)response to hypoxia3.204e-141.625e-05Highly InformativeDirect
Biological Process (BP)steroid biosynthetic process1.858e-100Highly InformativeDirect
Biological Process (BP)steroid catabolic process2.531e-078.346e-13Highly InformativeDirect
Biological Process (BP)xenobiotic metabolic process5.059e-060Highly InformativeDirect
Biological Process (BP)glycoside metabolic process2.511e-054.753e-07Highly InformativeDirect
Biological Process (BP)antibiotic biosynthetic process7.211e-068.024e-05Highly InformativeDirect
Biological Process (BP)negative regulation of response to external stimulus03.814e-07Highly InformativeDirect
Biological Process (BP)unsaturated fatty acid metabolic process1.631e-090Highly InformativeDirect
Biological Process (BP)cellular hormone metabolic process0.00031850Highly InformativeDirect
Biological Process (BP)hormone biosynthetic process1.096e-060Highly InformativeDirect
Biological Process (BP)negative regulation of sequence-specific DNA binding transcription factor activity07.58e-10Highly InformativeDirect
Biological Process (BP)regulation of nitric oxide biosynthetic process07.333e-15Highly InformativeDirect
Biological Process (BP)regulation of angiogenesis01.342e-05Highly InformativeDirect
Biological Process (BP)regulation of inflammatory response3.204e-140.0004014Highly InformativeDirect
Biological Process (BP)regulation of steroid biosynthetic process0.00017091.465e-05Highly InformativeDirect
Biological Process (BP)fatty acid derivative metabolic process00Highly InformativeDirect
Biological Process (BP)cellular response to organic cyclic compound0.66280.7677Highly InformativeInherited
Biological Process (BP)cellular response to alcohol0.1480.04158Highly InformativeInherited
Biological Process (BP)response to carbohydrate stimulus0.073220.3108Highly InformativeInherited
Biological Process (BP)carbohydrate homeostasis0.0095460.2415Highly InformativeInherited
Biological Process (BP)regulation of cellular ketone metabolic process0.0082210.08043Highly InformativeInherited
Biological Process (BP)alcohol biosynthetic process0.11011.598e-07Highly InformativeInherited
Biological Process (BP)polyol metabolic process11Highly InformativeInherited
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)oxidoreductase activity00Moderately InformativeDirect
Molecular Function (MF)isomerase activity8.428e-080.004521Moderately InformativeInherited
Molecular Function (MF)intramolecular oxidoreductase activity1.321e-153.416e-13InformativeDirect
Molecular Function (MF)tetrapyrrole binding4.054e-090InformativeDirect
Molecular Function (MF)monooxygenase activity00Highly InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge1.973e-150Highly InformativeDirect
Molecular Function (MF)heme binding2.199e-090Highly InformativeDirect
Cellular Component (CC)membrane0.88151Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.79741Least InformativeInherited
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)endoplasmic reticulum1.044e-120Moderately InformativeDirect
Cellular Component (CC)plasma membrane part9.842e-051Moderately InformativeInherited
Cellular Component (CC)membrane raft03.941e-05Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biosynthetic process 0 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) lipid biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) monocarboxylic acid metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) single-organism biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 3.524e-08 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of programmed cell death 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.7865 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.3135 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.4127 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cofactor metabolic process 0.3639 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.04874 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound catabolic process 0.9271 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) homeostatic process 1 Moderately Informative Inherited
Biological Process (BP) alcohol metabolic process 0 Informative Direct
Biological Process (BP) fatty acid metabolic process 1.398e-09 Informative Direct
Biological Process (BP) isoprenoid metabolic process 6.861e-09 Informative Direct
Biological Process (BP) vitamin metabolic process 7.003e-12 Informative Direct
Biological Process (BP) steroid metabolic process 0 Informative Direct
Biological Process (BP) regulation of hormone levels 0 Informative Direct
Biological Process (BP) response to organic cyclic compound 3.052e-06 Informative Direct
Biological Process (BP) lipid catabolic process 1.732e-05 Informative Direct
Biological Process (BP) secondary metabolic process 3.746e-15 Informative Direct
Biological Process (BP) regulation of response to external stimulus 0.0008845 Informative Direct
Biological Process (BP) cellular ketone metabolic process 0 Informative Direct
Biological Process (BP) monocarboxylic acid biosynthetic process 2.905e-05 Informative Direct
Biological Process (BP) organic hydroxy compound biosynthetic process 3.443e-14 Informative Direct
Biological Process (BP) biological adhesion 1 Informative Inherited
Biological Process (BP) response to cytokine stimulus 0.04604 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 1 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) response to lipid 0.03751 Informative Inherited
Biological Process (BP) sensory organ development 1 Informative Inherited
Biological Process (BP) cardiovascular system development 1 Informative Inherited
Biological Process (BP) cation homeostasis 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.9437 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.645 Informative Inherited
Biological Process (BP) coenzyme biosynthetic process 0.01031 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 1 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 0.3242 Informative Inherited
Biological Process (BP) regulation of defense response 0.08691 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.6683 Informative Inherited
Biological Process (BP) cellular amide metabolic process 0.1027 Informative Inherited
Biological Process (BP) phospholipid metabolic process 1 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.1858 Informative Inherited
Biological Process (BP) glycosyl compound biosynthetic process 0.0121 Informative Inherited
Biological Process (BP) sulfur compound biosynthetic process 0.3458 Informative Inherited
Biological Process (BP) anion transport 1 Informative Inherited
Biological Process (BP) nitrogen compound transport 1 Informative Inherited
Biological Process (BP) cellular component morphogenesis 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) response to inorganic substance 0.893 Informative Inherited
Biological Process (BP) cellular biogenic amine metabolic process 1 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.03495 Informative Inherited
Biological Process (BP) blood circulation 0.004917 Informative Inherited
Biological Process (BP) response to hypoxia 1.625e-05 Highly Informative Direct
Biological Process (BP) tryptophan metabolic process 8.196e-06 Highly Informative Direct
Biological Process (BP) steroid biosynthetic process 0 Highly Informative Direct
Biological Process (BP) steroid catabolic process 8.346e-13 Highly Informative Direct
Biological Process (BP) xenobiotic metabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of blood pressure 0.0001208 Highly Informative Direct
Biological Process (BP) isoprenoid biosynthetic process 3.114e-05 Highly Informative Direct
Biological Process (BP) toxin metabolic process 0 Highly Informative Direct
Biological Process (BP) response to toxic substance 2.929e-05 Highly Informative Direct
Biological Process (BP) phenylpropanoid metabolic process 7.059e-07 Highly Informative Direct
Biological Process (BP) sterol metabolic process 2.159e-06 Highly Informative Direct
Biological Process (BP) glycoside metabolic process 4.753e-07 Highly Informative Direct
Biological Process (BP) antibiotic biosynthetic process 8.024e-05 Highly Informative Direct
Biological Process (BP) negative regulation of response to external stimulus 3.814e-07 Highly Informative Direct
Biological Process (BP) unsaturated fatty acid metabolic process 0 Highly Informative Direct
Biological Process (BP) cellular hormone metabolic process 0 Highly Informative Direct
Biological Process (BP) ketone biosynthetic process 7.895e-13 Highly Informative Direct
Biological Process (BP) quinone cofactor metabolic process 8.144e-07 Highly Informative Direct
Biological Process (BP) cellular biogenic amine catabolic process 0.0004345 Highly Informative Direct
Biological Process (BP) indole-containing compound biosynthetic process 2.143e-05 Highly Informative Direct
Biological Process (BP) hormone biosynthetic process 0 Highly Informative Direct
Biological Process (BP) negative regulation of sequence-specific DNA binding transcription factor activity 7.58e-10 Highly Informative Direct
Biological Process (BP) regulation of nitric oxide biosynthetic process 7.333e-15 Highly Informative Direct
Biological Process (BP) regulation of angiogenesis 1.342e-05 Highly Informative Direct
Biological Process (BP) alcohol biosynthetic process 1.598e-07 Highly Informative Direct
Biological Process (BP) regulation of inflammatory response 0.0004014 Highly Informative Direct
Biological Process (BP) regulation of steroid biosynthetic process 1.465e-05 Highly Informative Direct
Biological Process (BP) regulation of coagulation 3.561e-05 Highly Informative Direct
Biological Process (BP) regulation of wound healing 0.0002831 Highly Informative Direct
Biological Process (BP) regulation of hemostasis 2.118e-05 Highly Informative Direct
Biological Process (BP) fatty acid derivative metabolic process 0 Highly Informative Direct
Biological Process (BP) cell adhesion 1 Highly Informative Inherited
Biological Process (BP) cellular response to organic cyclic compound 0.7677 Highly Informative Inherited
Biological Process (BP) cellular response to alcohol 0.04158 Highly Informative Inherited
Biological Process (BP) response to carbohydrate stimulus 0.3108 Highly Informative Inherited
Biological Process (BP) carbohydrate homeostasis 0.2415 Highly Informative Inherited
Biological Process (BP) regulation of cellular ketone metabolic process 0.08043 Highly Informative Inherited
Biological Process (BP) retina development in camera-type eye 0.5097 Highly Informative Inherited
Biological Process (BP) secondary metabolite biosynthetic process 0.001115 Highly Informative Inherited
Biological Process (BP) response to drug 0.01114 Highly Informative Inherited
Biological Process (BP) quinone metabolic process 1 Highly Informative Inherited
Biological Process (BP) polyol metabolic process 1 Highly Informative Inherited
Biological Process (BP) fatty acid catabolic process 1 Highly Informative Inherited
Biological Process (BP) retinoid metabolic process 1 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.6588 Highly Informative Inherited
Biological Process (BP) cellular aldehyde metabolic process 0.08119 Highly Informative Inherited
Biological Process (BP) inorganic anion transport 0.1761 Highly Informative Inherited
Biological Process (BP) cellular component assembly involved in morphogenesis 0.9288 Highly Informative Inherited
Biological Process (BP) external encapsulating structure organization 0.05413 Highly Informative Inherited
Biological Process (BP) lipid modification 1 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.5169 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) isomerase activity 0.004521 Moderately Informative Inherited
Molecular Function (MF) intramolecular oxidoreductase activity 3.416e-13 Informative Direct
Molecular Function (MF) tetrapyrrole binding 0 Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on CH-OH group of donors 1 Informative Inherited
Molecular Function (MF) monooxygenase activity 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 0 Highly Informative Direct
Molecular Function (MF) heme binding 0 Highly Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0 Moderately Informative Direct
Cellular Component (CC) endomembrane system 1.384e-07 Moderately Informative Direct
Cellular Component (CC) plasma membrane part 1 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.01233 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum membrane 0 Informative Direct
Cellular Component (CC) membrane raft 3.941e-05 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Isomerases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0Moderately InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0.7611Moderately InformativeInherited
Enzyme Commission (EC)Hydro-lyases1Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Miscellaneous (requires further characterization)1InformativeInherited
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation0.02235InformativeInherited
Enzyme Commission (EC)Other intramolecular oxidoreductases0Highly InformativeDirect
Enzyme Commission (EC)With reduced flavin or flavoprotein as one donor, 0Highly InformativeDirect
Enzyme Commission (EC)With a reduced iron-sulfur protein as one donor, a1.495e-08Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)syndrome0.008538Moderately InformativeInherited
Disease Ontology (DO)endocrine system disease0.02375Moderately InformativeInherited
Disease Ontology (DO)physical disorder0.03929InformativeInherited
Disease Ontology (DO)hypospadias3.844e-05Highly InformativeDirect
Disease Ontology (DO)hyperandrogenism0.0002278Highly InformativeDirect
Disease Ontology (DO)thoracic disease0.0004198Highly InformativeDirect
Disease Ontology (DO)polycystic ovary syndrome0.0008453Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
ONset and clinical course (ON)Neonatal onset5.55e-05InformativeDirect
Phenotypic Abnormality (PA)Puberty and gonadal disorders0.0697InformativeInherited
Phenotypic Abnormality (PA)Adrenogenital syndrome8.441e-06Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.3742Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.7902Least InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.07711Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.2164Moderately InformativeInherited
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.4546Moderately InformativeInherited
Mammalian Phenotype (MP)digestive/alimentary phenotype0.5268Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal systemic arterial blood pressure6.787e-05InformativeDirect
Mammalian Phenotype (MP)abnormal internal female genitalia morphology0.06968InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.09799InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system physiology0.3941InformativeInherited
Mammalian Phenotype (MP)abnormal xenobiotic pharmacokinetics4.416e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal fat-soluble vitamin level0.0003181Highly InformativeDirect
Mammalian Phenotype (MP)abnormal uterus morphology0.005595Highly InformativeInherited
Mammalian Phenotype (MP)abnormal adrenal gland morphology0.006932Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.2164Least InformativeInherited
Worm Phenotype (WP)metal response variant0.0001096InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system subdivision0.04478Least InformativeInherited
Fly Anatomy (FA)anatomical group0.1244Least InformativeInherited
Fly Anatomy (FA)organ system0.2667Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.2695Least InformativeInherited
Fly Anatomy (FA)cell0.5758Least InformativeInherited
Fly Anatomy (FA)larva0.6039Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)acellular anatomical structure0.005022Moderately InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.01353Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.1351Moderately InformativeInherited
Fly Anatomy (FA)portion of tissue0.2107Moderately InformativeInherited
Fly Anatomy (FA)developing material anatomical entity0.3853Moderately InformativeInherited
Fly Anatomy (FA)head0.4378Moderately InformativeInherited
Fly Anatomy (FA)late embryo0.5223Moderately InformativeInherited
Fly Anatomy (FA)midgut1.821e-05InformativeDirect
Fly Anatomy (FA)tract7.138e-05InformativeDirect
Fly Anatomy (FA)alimentary canal0.0001556InformativeDirect
Fly Anatomy (FA)cuboidal/columnar epithelium0.0006645InformativeDirect
Fly Anatomy (FA)embryonic/larval digestive system0.001602InformativeInherited
Fly Anatomy (FA)embryonic/larval integumentary system0.01025InformativeInherited
Fly Anatomy (FA)primordium0.02445InformativeInherited
Fly Anatomy (FA)ganglion0.06319InformativeInherited
Fly Anatomy (FA)embryonic/larval central nervous system0.1158InformativeInherited
Fly Anatomy (FA)hindgut2.7e-06Highly InformativeDirect
Fly Anatomy (FA)neuropil glial sheath5.357e-06Highly InformativeDirect
Fly Anatomy (FA)presumptive embryonic/larval central nervous system1.337e-05Highly InformativeDirect
Fly Anatomy (FA)midgut primordium8.087e-05Highly InformativeDirect
Fly Anatomy (FA)embryonic epidermis0.000119Highly InformativeDirect
Fly Anatomy (FA)embryonic head0.0004957Highly InformativeDirect
Fly Anatomy (FA)CNS glial cell0.0007394Highly InformativeDirect
Fly Anatomy (FA)embryonic/first instar larval cuticle0.0009385Highly InformativeDirect

Document: FA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)fruit0.01248InformativeInherited

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Carbon-carbon lyases0.132Moderately InformativeInherited
Enzyme Commission (EC)Acting on the CH-OH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases1Moderately InformativeInherited
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen0InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0.922InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1InformativeInherited
Enzyme Commission (EC)Acting on single donors with incorporation of molecular oxygen1InformativeInherited
Enzyme Commission (EC)Acting on NADH or NADPH1InformativeInherited
Enzyme Commission (EC)Intramolecular transferases (mutases)1InformativeInherited
Enzyme Commission (EC)With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen0Highly InformativeDirect
Enzyme Commission (EC)Other intramolecular oxidoreductases0Highly InformativeDirect
Enzyme Commission (EC)Aldehyde-lyases4.808e-16Highly InformativeDirect
Enzyme Commission (EC)With a heme protein as acceptor8.519e-05Highly InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation of one atom of oxygen0.002392Highly InformativeInherited
Enzyme Commission (EC)With incorporation of two atoms of oxygen0.01679Highly InformativeInherited
Enzyme Commission (EC)Miscellaneous (requires further characterization)1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processLipid metabolism0Moderately InformativeDirect
Biological processSteroid metabolism0InformativeDirect
Biological processFatty acid metabolism1InformativeInherited
Biological processLipid biosynthesis1InformativeInherited
Biological processProstaglandin biosynthesis0Highly InformativeDirect
Biological processSteroid biosynthesis0Highly InformativeDirect
Biological processGrowth regulation2.496e-11Highly InformativeDirect
Biological processAntibiotic biosynthesis3.558e-09Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentMicrosome0Highly InformativeDirect
Coding sequence diversityPolymorphism5.508e-06Moderately InformativeDirect
DiseaseDisease mutation8.74e-05Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
DomainTransit peptide3.817e-07Moderately InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionIron0Moderately InformativeDirect
Molecular functionHeme0InformativeDirect
Molecular functionNADP0InformativeDirect
Molecular functionLipid-binding0.306InformativeInherited
Molecular functionSteroid-binding5.091e-09Highly InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationMonooxygenase0Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)lipid metabolism0Least InformativeDirect
UniPathway (UP)aromatic compound metabolism0.4761Least InformativeInherited
UniPathway (UP)secondary metabolite metabolism0Moderately InformativeDirect
UniPathway (UP)antibiotic biosynthesis8.762e-11Moderately InformativeDirect
UniPathway (UP)aromatic compound biosynthesis8.966e-06Moderately InformativeDirect
UniPathway (UP)nitrogen metabolism5.936e-05Moderately InformativeDirect
UniPathway (UP)pigment metabolism0.0114Moderately InformativeInherited
UniPathway (UP)lipid biosynthesis0.9552Moderately InformativeInherited
UniPathway (UP)fatty acid metabolism1Moderately InformativeInherited
UniPathway (UP)terpene metabolism0InformativeDirect
UniPathway (UP)alcohol biosynthesis0InformativeDirect
UniPathway (UP)alkaloid metabolism3.371e-11InformativeDirect
UniPathway (UP)hormone biosynthesis0.0006767InformativeDirect
UniPathway (UP)phenylpropanoid biosynthesis0.002165InformativeInherited
UniPathway (UP)pigment biosynthesis0.01092InformativeInherited
UniPathway (UP)flavonoid metabolism0.01442InformativeInherited
UniPathway (UP)plant hormone biosynthesis1InformativeInherited
UniPathway (UP)anthocyanin biosynthesis2.87e-11Highly InformativeDirect
UniPathway (UP)leukotriene metabolism3.154e-10Highly InformativeDirect
UniPathway (UP)monoterpene degradation8.571e-08Highly InformativeDirect
UniPathway (UP)benzoxazinone biosynthesis2.428e-07Highly InformativeDirect
UniPathway (UP)mycotoxin biosynthesis5.714e-07Highly InformativeDirect
UniPathway (UP)plant hormone degradation2.281e-06Highly InformativeDirect
UniPathway (UP)steroid hormone biosynthesis0.3777Highly InformativeInherited

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR001128 SSF48264 Protein matches
Abstract

More information about these proteins can be found at Protein of the Month: Cytochrome P450.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 23 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Cytochrome P450 domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 23 hidden Markov models representing the Cytochrome P450 superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]