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Cytochrome P450 superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Cytochrome P450 [ 48263]
Superfamily:   Cytochrome P450 [ 48264]
Families:   Cytochrome P450 [ 48265] (22)


Superfamily statistics
Genomes (1,314) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 58,076 218,529 76
Proteins 56,654 215,280 76


Functional annotation
General category Metabolism
Detailed category Redox

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Isomerases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0Moderately InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0.7611Moderately InformativeInherited
Enzyme Commission (EC)Hydro-lyases1Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Miscellaneous (requires further characterization)1InformativeInherited
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation0.02235InformativeInherited
Enzyme Commission (EC)Other intramolecular oxidoreductases0Highly InformativeDirect
Enzyme Commission (EC)With reduced flavin or flavoprotein as one donor, 0Highly InformativeDirect
Enzyme Commission (EC)With a reduced iron-sulfur protein as one donor, a0.00000001495Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)connective tissue disease0.01385Moderately InformativeInherited
Disease Ontology (DO)endocrine system disease0.02738Moderately InformativeInherited
Disease Ontology (DO)physical disorder0.05337InformativeInherited
Disease Ontology (DO)hypospadias0.000128Highly InformativeDirect
Disease Ontology (DO)hyperandrogenism0.0002464Highly InformativeDirect
Disease Ontology (DO)bone remodeling disease0.0009232Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.08968Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.4763Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the skeletal system0.6006Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.9503Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the urinary system0.2401Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.3418Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal reproductive system morphology0.6944Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of circulating hormone level0.1177InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ovary0.1395InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the hypothalamus-pituitary axis0.2096InformativeInherited
Phenotypic Abnormality (PA)Abnormality of long bone morphology0.3015InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cation homeostasis0.6204InformativeInherited
Phenotypic Abnormality (PA)Hyperaldosteronism0.000002318Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal circulating renin0.000002318Highly InformativeDirect
Phenotypic Abnormality (PA)Primary adrenal insufficiency0.00006593Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal urinary electrolyte concentration0.000513Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of circulating adrenocorticotropin level0.001352Highly InformativeInherited
Phenotypic Abnormality (PA)Polycystic ovaries0.005469Highly InformativeInherited
Phenotypic Abnormality (PA)Hyperpituitarism0.008955Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal breast morphology0.03532Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of epiphysis morphology0.1257Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal enchondral ossification0.1593Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.2315Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.7948Least InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.0008476Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.1999Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.2633Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal systemic arterial blood pressure0.00007036InformativeDirect
Mammalian Phenotype (MP)abnormal circulating lipid level0.0545InformativeInherited
Mammalian Phenotype (MP)abnormal xenobiotic pharmacokinetics0.000007534Highly InformativeDirect
Mammalian Phenotype (MP)abnormal fat-soluble vitamin level0.0004308Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism behavior variant0Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.3847Least InformativeInherited
Worm Phenotype (WP)defecation variant0InformativeDirect
Worm Phenotype (WP)metal response variant0.0001019InformativeDirect
Worm Phenotype (WP)defecation cycle variant0Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)integumentary system0.01504Least InformativeInherited
Fly Anatomy (FA)embryo0.1682Least InformativeInherited
Fly Anatomy (FA)anatomical group0.3033Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.3277Least InformativeInherited
Fly Anatomy (FA)larva0.432Least InformativeInherited
Fly Anatomy (FA)somatic cell0.544Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.5661Least InformativeInherited
Fly Anatomy (FA)nervous system0.6781Least InformativeInherited
Fly Anatomy (FA)non-connected developing system0.01439Moderately InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.0329Moderately InformativeInherited
Fly Anatomy (FA)developing embryonic structure0.038Moderately InformativeInherited
Fly Anatomy (FA)epithelium0.0581Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.1438Moderately InformativeInherited
Fly Anatomy (FA)ganglion0.1584Moderately InformativeInherited
Fly Anatomy (FA)late embryo0.4784Moderately InformativeInherited
Fly Anatomy (FA)midline crossing tract0.000007127InformativeDirect
Fly Anatomy (FA)cuboidal/columnar epithelium0.0002403InformativeDirect
Fly Anatomy (FA)digestive system0.005083InformativeInherited
Fly Anatomy (FA)ventral nerve cord0.01719InformativeInherited
Fly Anatomy (FA)primordium0.0329InformativeInherited
Fly Anatomy (FA)commissure0.000006677Highly InformativeDirect
Fly Anatomy (FA)hindgut0.000008724Highly InformativeDirect
Fly Anatomy (FA)neuropil glial sheath0.00001951Highly InformativeDirect
Fly Anatomy (FA)presumptive embryonic/larval central nervous system0.00004235Highly InformativeDirect
Fly Anatomy (FA)midgut primordium0.0001919Highly InformativeDirect
Fly Anatomy (FA)CNS glial cell0.0004005Highly InformativeDirect
Fly Anatomy (FA)embryonic epidermis0.4169Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus DEvelopment stage (XDE)post-embryonic stage0.3874Least InformativeInherited
Xenopus DEvelopment stage (XDE)climax stage1Moderately InformativeInherited
Xenopus DEvelopment stage (XDE)NF stage 620.00002924Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)fruit0.01271InformativeInherited

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on the CH-OH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases1Moderately InformativeInherited
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0.8113InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1InformativeInherited
Enzyme Commission (EC)Acting on single donors with incorporation of molecular oxygen (oxygenases). The oxygen incorporated1InformativeInherited
Enzyme Commission (EC)Acting on NADH or NADPH1InformativeInherited
Enzyme Commission (EC)Intramolecular transferases1InformativeInherited
Enzyme Commission (EC)With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen0Highly InformativeDirect
Enzyme Commission (EC)Other intramolecular oxidoreductases0Highly InformativeDirect
Enzyme Commission (EC)With a heme protein as acceptor0.00000003753Highly InformativeDirect
Enzyme Commission (EC)With incorporation of two atoms of oxygen0.02841Highly InformativeInherited
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation of one atom of oxygen0.03541Highly InformativeInherited
Enzyme Commission (EC)With another compound as one donor, and incorporation of one atom of oxygen1Highly InformativeInherited

Document: EC annotation of SCOP domains

InterPro annotation
Cross references IPR001128 SSF48264 Protein matches
Abstract

More information about these proteins can be found at Protein of the Month: Cytochrome P450.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 23 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Cytochrome P450 domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 23 hidden Markov models representing the Cytochrome P450 superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]