SUPERFAMILY 1.75 HMM library and genome assignments server

Cytochrome P450 superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Cytochrome P450 [ 48263]
Superfamily:   Cytochrome P450 [ 48264]
Families:   Cytochrome P450 [ 48265] (22)


Superfamily statistics
Genomes (1,307) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 57,841 77,510 76
Proteins 56,461 76,848 76


Functional annotation
General category Metabolism
Detailed category Redox

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biosynthetic process0.000000000078230Least InformativeDirect
Biological Process (BP)single-organism metabolic process0.00000000058270Least InformativeDirect
Biological Process (BP)organic cyclic compound metabolic process0.00060470Least InformativeDirect
Biological Process (BP)heterocycle metabolic process11Least InformativeInherited
Biological Process (BP)positive regulation of biological process0.22521Least InformativeInherited
Biological Process (BP)single-organism cellular process0.4121Least InformativeInherited
Biological Process (BP)response to stimulus0.26151Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.23421Least InformativeInherited
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)lipid metabolic process00Moderately InformativeDirect
Biological Process (BP)monocarboxylic acid metabolic process0.00000000023570Moderately InformativeDirect
Biological Process (BP)small molecule biosynthetic process0.000000000029080.0000000000000406Moderately InformativeDirect
Biological Process (BP)cellular response to chemical stimulus0.00000040940.00000003028Moderately InformativeDirect
Biological Process (BP)organic cyclic compound biosynthetic process0.0000010440Moderately InformativeDirect
Biological Process (BP)organic hydroxy compound metabolic process0.0000000000054650Moderately InformativeDirect
Biological Process (BP)heterocycle biosynthetic process0.078830.2524Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.0034031Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.0000027810.8683Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound11Moderately InformativeInherited
Biological Process (BP)response to organic substance0.024391Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.000062581Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.00052471Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process0.00069721Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.098651Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process0.000093111Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.090081Moderately InformativeInherited
Biological Process (BP)positive regulation of response to stimulus0.00041281Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.0010131Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.020551Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.0040871Moderately InformativeInherited
Biological Process (BP)regulation of macromolecule biosynthetic process0.0017291Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process11Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.63291Moderately InformativeInherited
Biological Process (BP)single-organism catabolic process0.71951Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.047610.0005332Moderately InformativeInherited
Biological Process (BP)alcohol metabolic process0.000000000036980InformativeDirect
Biological Process (BP)fatty acid metabolic process0.00072280.00000000001009InformativeDirect
Biological Process (BP)regulation of hormone levels0.0000016760InformativeDirect
Biological Process (BP)secondary metabolic process0.00081990InformativeDirect
Biological Process (BP)monocarboxylic acid biosynthetic process0.00000000002490.000007969InformativeDirect
Biological Process (BP)organic hydroxy compound biosynthetic process0.000086820InformativeDirect
Biological Process (BP)regulation of response to wounding0.000000000003930.0000009726InformativeDirect
Biological Process (BP)positive regulation of cell death0.00000000013060.09601InformativeInherited
Biological Process (BP)regulation of apoptotic process0.0000069191InformativeInherited
Biological Process (BP)cellular response to oxygen-containing compound0.99991InformativeInherited
Biological Process (BP)cellular chemical homeostasis0.59591InformativeInherited
Biological Process (BP)regulation of lipid metabolic process0.042390.1971InformativeInherited
Biological Process (BP)response to cytokine0.00000073580.04175InformativeInherited
Biological Process (BP)regulation of response to external stimulus0.000000004560.007379InformativeInherited
Biological Process (BP)regulation of defense response0.000000004710.1066InformativeInherited
Biological Process (BP)positive regulation of developmental process0.000000002650.6651InformativeInherited
Biological Process (BP)positive regulation of multicellular organismal process0.00000008651InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis0.000027470.7261InformativeInherited
Biological Process (BP)negative regulation of biosynthetic process0.000000058821InformativeInherited
Biological Process (BP)negative regulation of nitrogen compound metabolic process0.0000000078471InformativeInherited
Biological Process (BP)vitamin metabolic process0.3860.000000000004513InformativeInherited
Biological Process (BP)response to lipid0.95890.04105InformativeInherited
Biological Process (BP)response to organic cyclic compound0.73880.000003205InformativeInherited
Biological Process (BP)negative regulation of response to stimulus0.00000080170.2802InformativeInherited
Biological Process (BP)glycosyl compound biosynthetic process0.22060.02725InformativeInherited
Biological Process (BP)lipid catabolic process0.0012510.00000005146InformativeInherited
Biological Process (BP)isoprenoid metabolic process0.25450.00000000006558InformativeInherited
Biological Process (BP)response to hypoxia0.00000000000023590.00005028Highly InformativeDirect
Biological Process (BP)icosanoid metabolic process0.00000000000062460Highly InformativeDirect
Biological Process (BP)steroid biosynthetic process0.00000000025270Highly InformativeDirect
Biological Process (BP)steroid catabolic process0.0000000031340.00000000000008518Highly InformativeDirect
Biological Process (BP)xenobiotic metabolic process0.00000067860Highly InformativeDirect
Biological Process (BP)sterol metabolic process0.000062930.0000002787Highly InformativeDirect
Biological Process (BP)glycoside metabolic process0.00004530.00000091Highly InformativeDirect
Biological Process (BP)antibiotic biosynthetic process0.000000041250.000002611Highly InformativeDirect
Biological Process (BP)negative regulation of defense response0.0000000000000063590.00002823Highly InformativeDirect
Biological Process (BP)negative regulation of response to external stimulus0.0000000000000094410.000000002515Highly InformativeDirect
Biological Process (BP)unsaturated fatty acid metabolic process0.000000011370Highly InformativeDirect
Biological Process (BP)cellular hormone metabolic process0.00042910Highly InformativeDirect
Biological Process (BP)hormone biosynthetic process0.0000013240Highly InformativeDirect
Biological Process (BP)negative regulation of sequence-specific DNA binding transcription factor activity00.000000000002769Highly InformativeDirect
Biological Process (BP)regulation of nitric oxide biosynthetic process00.000000000000009016Highly InformativeDirect
Biological Process (BP)positive regulation of angiogenesis0.0000000000019780.00000000002584Highly InformativeDirect
Biological Process (BP)regulation of steroid biosynthetic process0.00019220.00001223Highly InformativeDirect
Biological Process (BP)fatty acid derivative biosynthetic process0.00000000000011440.00000000000003411Highly InformativeDirect
Biological Process (BP)negative regulation of response to wounding00.000000000000003707Highly InformativeDirect
Biological Process (BP)response to alcohol0.57240.003326Highly InformativeInherited
Biological Process (BP)response to carbohydrate0.075810.302Highly InformativeInherited
Biological Process (BP)regulation of cellular ketone metabolic process0.0067950.1012Highly InformativeInherited
Biological Process (BP)polyol biosynthetic process0.16390.1769Highly InformativeInherited
Biological Process (BP)secondary metabolite biosynthetic process0.0015350.00000000000007575Highly InformativeInherited
Biological Process (BP)alcohol catabolic process0.000052830.03461Highly InformativeInherited
Biological Process (BP)carbohydrate homeostasis0.013660.2735Highly InformativeInherited
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)oxidoreductase activity00Moderately InformativeDirect
Molecular Function (MF)isomerase activity0.00000051740.01063Moderately InformativeInherited
Molecular Function (MF)cation binding0.033811Moderately InformativeInherited
Molecular Function (MF)intramolecular oxidoreductase activity0.0000000000000039370.0000000000004837InformativeDirect
Molecular Function (MF)tetrapyrrole binding00InformativeDirect
Molecular Function (MF)monooxygenase activity00Highly InformativeDirect
Molecular Function (MF)iron ion binding0.0000040390.0001759Highly InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge00Highly InformativeDirect
Molecular Function (MF)heme binding00Highly InformativeDirect
Cellular Component (CC)membrane0.90381Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.97791Least InformativeInherited
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)endoplasmic reticulum0.0000000000060020Moderately InformativeDirect
Cellular Component (CC)membrane region0.00000000025030.000000000000228Moderately InformativeDirect
Cellular Component (CC)plasma membrane part0.00030331Moderately InformativeInherited
Cellular Component (CC)plasma membrane region0.000000000015220.0002329InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biosynthetic process 0 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0 Least Informative Direct
Biological Process (BP) positive regulation of biological process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) monocarboxylic acid metabolic process 0 Moderately Informative Direct
Biological Process (BP) small molecule biosynthetic process 0.0000000000000406 Moderately Informative Direct
Biological Process (BP) oxidation-reduction process 0.0007019 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.0005332 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.00000003028 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.8683 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.9344 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.1727 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.2524 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.5541 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) cofactor metabolic process 0.1255 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 1 Moderately Informative Inherited
Biological Process (BP) alcohol metabolic process 0 Informative Direct
Biological Process (BP) fatty acid metabolic process 0.00000000001009 Informative Direct
Biological Process (BP) isoprenoid metabolic process 0.00000000006558 Informative Direct
Biological Process (BP) vitamin metabolic process 0.000000000004513 Informative Direct
Biological Process (BP) coenzyme biosynthetic process 0.000706 Informative Direct
Biological Process (BP) regulation of hormone levels 0 Informative Direct
Biological Process (BP) response to organic cyclic compound 0.000003205 Informative Direct
Biological Process (BP) lipid catabolic process 0.00000005146 Informative Direct
Biological Process (BP) secondary metabolic process 0 Informative Direct
Biological Process (BP) cellular ketone metabolic process 0 Informative Direct
Biological Process (BP) monocarboxylic acid biosynthetic process 0.000007969 Informative Direct
Biological Process (BP) organic hydroxy compound biosynthetic process 0 Informative Direct
Biological Process (BP) regulation of response to wounding 0.0000009726 Informative Direct
Biological Process (BP) positive regulation of cell death 0.09601 Informative Inherited
Biological Process (BP) regulation of apoptotic process 1 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) biological adhesion 1 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 1 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.1971 Informative Inherited
Biological Process (BP) response to cytokine 0.04175 Informative Inherited
Biological Process (BP) sensory organ development 1 Informative Inherited
Biological Process (BP) cardiovascular system development 1 Informative Inherited
Biological Process (BP) cation homeostasis 1 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.0179 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.007379 Informative Inherited
Biological Process (BP) regulation of defense response 0.1066 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) cellular biogenic amine metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.6651 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.7261 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 1 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 1 Informative Inherited
Biological Process (BP) response to lipid 0.04105 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.2802 Informative Inherited
Biological Process (BP) cellular aldehyde metabolic process 0.003495 Informative Inherited
Biological Process (BP) phospholipid metabolic process 1 Informative Inherited
Biological Process (BP) glycosyl compound biosynthetic process 0.02725 Informative Inherited
Biological Process (BP) sulfur compound biosynthetic process 0.5584 Informative Inherited
Biological Process (BP) anion transport 1 Informative Inherited
Biological Process (BP) nitrogen compound transport 1 Informative Inherited
Biological Process (BP) cellular component morphogenesis 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) response to acid chemical 0.2574 Informative Inherited
Biological Process (BP) response to inorganic substance 0.6818 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 0.2775 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 1 Informative Inherited
Biological Process (BP) blood circulation 0.001188 Informative Inherited
Biological Process (BP) response to hypoxia 0.00005028 Highly Informative Direct
Biological Process (BP) tryptophan metabolic process 0.000006851 Highly Informative Direct
Biological Process (BP) icosanoid metabolic process 0 Highly Informative Direct
Biological Process (BP) steroid biosynthetic process 0 Highly Informative Direct
Biological Process (BP) steroid catabolic process 0.00000000000008518 Highly Informative Direct
Biological Process (BP) xenobiotic metabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of blood pressure 0.00001316 Highly Informative Direct
Biological Process (BP) isoprenoid biosynthetic process 0.000001666 Highly Informative Direct
Biological Process (BP) toxin metabolic process 0 Highly Informative Direct
Biological Process (BP) response to toxic substance 0.00002048 Highly Informative Direct
Biological Process (BP) phenylpropanoid metabolic process 0.0000000004188 Highly Informative Direct
Biological Process (BP) sterol metabolic process 0.0000002787 Highly Informative Direct
Biological Process (BP) glycoside metabolic process 0.00000091 Highly Informative Direct
Biological Process (BP) antibiotic biosynthetic process 0.000002611 Highly Informative Direct
Biological Process (BP) negative regulation of defense response 0.00002823 Highly Informative Direct
Biological Process (BP) negative regulation of response to external stimulus 0.000000002515 Highly Informative Direct
Biological Process (BP) unsaturated fatty acid metabolic process 0 Highly Informative Direct
Biological Process (BP) cellular hormone metabolic process 0 Highly Informative Direct
Biological Process (BP) ketone biosynthetic process 0 Highly Informative Direct
Biological Process (BP) cellular biogenic amine catabolic process 0.0003609 Highly Informative Direct
Biological Process (BP) indole-containing compound biosynthetic process 0.00003754 Highly Informative Direct
Biological Process (BP) hormone biosynthetic process 0 Highly Informative Direct
Biological Process (BP) negative regulation of sequence-specific DNA binding transcription factor activity 0.000000000002769 Highly Informative Direct
Biological Process (BP) secondary metabolite biosynthetic process 0.00000000000007575 Highly Informative Direct
Biological Process (BP) regulation of nitric oxide biosynthetic process 0.000000000000009016 Highly Informative Direct
Biological Process (BP) positive regulation of angiogenesis 0.00000000002584 Highly Informative Direct
Biological Process (BP) regulation of steroid biosynthetic process 0.00001223 Highly Informative Direct
Biological Process (BP) negative regulation of coagulation 0.0000003814 Highly Informative Direct
Biological Process (BP) monovalent inorganic cation homeostasis 0.0001957 Highly Informative Direct
Biological Process (BP) negative regulation of hemostasis 0.0000001573 Highly Informative Direct
Biological Process (BP) fatty acid derivative biosynthetic process 0.00000000000003411 Highly Informative Direct
Biological Process (BP) quinone metabolic process 0.0009807 Highly Informative Direct
Biological Process (BP) negative regulation of response to wounding 0.000000000000003707 Highly Informative Direct
Biological Process (BP) cell adhesion 1 Highly Informative Inherited
Biological Process (BP) response to alcohol 0.003326 Highly Informative Inherited
Biological Process (BP) response to carbohydrate 0.302 Highly Informative Inherited
Biological Process (BP) regulation of cellular ketone metabolic process 0.1012 Highly Informative Inherited
Biological Process (BP) retina development in camera-type eye 0.201 Highly Informative Inherited
Biological Process (BP) fatty acid catabolic process 1 Highly Informative Inherited
Biological Process (BP) response to drug 0.005176 Highly Informative Inherited
Biological Process (BP) retinoid metabolic process 1 Highly Informative Inherited
Biological Process (BP) polyol biosynthetic process 0.1769 Highly Informative Inherited
Biological Process (BP) regulation of wound healing 0.2562 Highly Informative Inherited
Biological Process (BP) alcohol catabolic process 0.03461 Highly Informative Inherited
Biological Process (BP) inorganic anion transport 0.2864 Highly Informative Inherited
Biological Process (BP) external encapsulating structure organization 0.05402 Highly Informative Inherited
Biological Process (BP) lipid modification 1 Highly Informative Inherited
Biological Process (BP) cellular component assembly involved in morphogenesis 0.987 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.6168 Highly Informative Inherited
Biological Process (BP) carbohydrate homeostasis 0.2735 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) isomerase activity 0.01063 Moderately Informative Inherited
Molecular Function (MF) cation binding 1 Moderately Informative Inherited
Molecular Function (MF) intramolecular oxidoreductase activity 0.0000000000004837 Informative Direct
Molecular Function (MF) tetrapyrrole binding 0 Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on CH-OH group of donors 1 Informative Inherited
Molecular Function (MF) monooxygenase activity 0 Highly Informative Direct
Molecular Function (MF) iron ion binding 0.0001759 Highly Informative Direct
Molecular Function (MF) drug binding 0.0003439 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 0 Highly Informative Direct
Molecular Function (MF) heme binding 0 Highly Informative Direct
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0 Moderately Informative Direct
Cellular Component (CC) bounding membrane of organelle 0.0002867 Moderately Informative Direct
Cellular Component (CC) membrane region 0.000000000000228 Moderately Informative Direct
Cellular Component (CC) plasma membrane part 1 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum membrane 0 Informative Direct
Cellular Component (CC) plasma membrane region 0.0002329 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Isomerases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0Moderately InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0.7611Moderately InformativeInherited
Enzyme Commission (EC)Hydro-lyases1Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Miscellaneous (requires further characterization)1InformativeInherited
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation0.02235InformativeInherited
Enzyme Commission (EC)Other intramolecular oxidoreductases0Highly InformativeDirect
Enzyme Commission (EC)With reduced flavin or flavoprotein as one donor, 0Highly InformativeDirect
Enzyme Commission (EC)With a reduced iron-sulfur protein as one donor, a0.00000001495Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)endocrine system disease0.02164Moderately InformativeInherited
Disease Ontology (DO)artery disease0.1138Moderately InformativeInherited
Disease Ontology (DO)connective tissue disease0.1942Moderately InformativeInherited
Disease Ontology (DO)physical disorder0.03841InformativeInherited
Disease Ontology (DO)coronary artery disease0.5892InformativeInherited
Disease Ontology (DO)hypospadias0.00005816Highly InformativeDirect
Disease Ontology (DO)bone resorption disease0.0001184Highly InformativeDirect
Disease Ontology (DO)hyperandrogenism0.0002118Highly InformativeDirect
Disease Ontology (DO)thoracic disease0.0003905Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Puberty and gonadal disorders0.07106InformativeInherited
Phenotypic Abnormality (PA)Adrenogenital syndrome0.000007846Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.3052Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.8143Least InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.01886Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.1501Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.2078Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.4387Moderately InformativeInherited
Mammalian Phenotype (MP)digestive/alimentary phenotype0.5659Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal systemic arterial blood pressure0.000105InformativeDirect
Mammalian Phenotype (MP)abnormal digestive system physiology0.4132InformativeInherited
Mammalian Phenotype (MP)abnormal xenobiotic pharmacokinetics0.00002897Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating aldosterone level0.0002673Highly InformativeDirect
Mammalian Phenotype (MP)abnormal fat-soluble vitamin level0.0002673Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.2164Least InformativeInherited
Worm Phenotype (WP)metal response variant0.0001096InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

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FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system subdivision0.04051Least InformativeInherited
Fly Anatomy (FA)anatomical group0.1119Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.2504Least InformativeInherited
Fly Anatomy (FA)organ system0.2589Least InformativeInherited
Fly Anatomy (FA)cell0.5655Least InformativeInherited
Fly Anatomy (FA)larva0.5948Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)acellular anatomical structure0.004302Moderately InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.01228Moderately InformativeInherited
Fly Anatomy (FA)epithelium0.03215Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.1314Moderately InformativeInherited
Fly Anatomy (FA)developing material anatomical entity0.3653Moderately InformativeInherited
Fly Anatomy (FA)late embryo0.5201Moderately InformativeInherited
Fly Anatomy (FA)commissure0.00000659InformativeDirect
Fly Anatomy (FA)midgut0.00002336InformativeDirect
Fly Anatomy (FA)alimentary canal0.0001632InformativeDirect
Fly Anatomy (FA)cuboidal/columnar epithelium0.0006333InformativeDirect
Fly Anatomy (FA)embryonic/larval digestive system0.001394InformativeInherited
Fly Anatomy (FA)embryonic/larval integumentary system0.009182InformativeInherited
Fly Anatomy (FA)primordium0.021InformativeInherited
Fly Anatomy (FA)embryonic/larval central nervous system0.1108InformativeInherited
Fly Anatomy (FA)hindgut0.000002191Highly InformativeDirect
Fly Anatomy (FA)neuropil glial sheath0.000003398Highly InformativeDirect
Fly Anatomy (FA)presumptive embryonic/larval central nervous system0.00001034Highly InformativeDirect
Fly Anatomy (FA)midgut primordium0.00007199Highly InformativeDirect
Fly Anatomy (FA)embryonic epidermis0.0001061Highly InformativeDirect
Fly Anatomy (FA)embryonic head0.0003984Highly InformativeDirect
Fly Anatomy (FA)CNS glial cell0.000639Highly InformativeDirect
Fly Anatomy (FA)embryonic/first instar larval cuticle0.0008539Highly InformativeDirect

Document: FA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

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AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)fruit0.01248InformativeInherited

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

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EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Carbon-carbon lyases0.1435Moderately InformativeInherited
Enzyme Commission (EC)Acting on the CH-OH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases1Moderately InformativeInherited
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen0InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0.9157InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1InformativeInherited
Enzyme Commission (EC)Acting on single donors with incorporation of molecular oxygen1InformativeInherited
Enzyme Commission (EC)Acting on NADH or NADPH1InformativeInherited
Enzyme Commission (EC)Intramolecular transferases (mutases)1InformativeInherited
Enzyme Commission (EC)With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen0Highly InformativeDirect
Enzyme Commission (EC)Other intramolecular oxidoreductases0Highly InformativeDirect
Enzyme Commission (EC)Aldehyde-lyases4.839e-16Highly InformativeDirect
Enzyme Commission (EC)Transferring hydroxy groups0.00000003316Highly InformativeDirect
Enzyme Commission (EC)With a heme protein as acceptor0.0000829Highly InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation of one atom of oxygen0.002176Highly InformativeInherited
Enzyme Commission (EC)With incorporation of two atoms of oxygen0.01737Highly InformativeInherited
Enzyme Commission (EC)Miscellaneous (requires further characterization)1Highly InformativeInherited

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

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DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)antiinfectives for systemic use0.02999Least InformativeInherited
Drugbank ATC_code (DB)nervous system0.3469Least InformativeInherited
Drugbank ATC_code (DB)genito urinary system and sex hormones0.003555Moderately InformativeInherited
Drugbank ATC_code (DB)psycholeptics0.03611Moderately InformativeInherited
Drugbank ATC_code (DB)antifungals for topical use1Moderately InformativeInherited
Drugbank ATC_code (DB)hormone antagonists and related agents0.00009312InformativeDirect
Drugbank ATC_code (DB)ketoconazole0.0000006213Highly InformativeDirect
Drugbank ATC_code (DB)paliperidone0.0001159Highly InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

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KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processLipid metabolism0Moderately InformativeDirect
Biological processSteroid metabolism0InformativeDirect
Biological processFatty acid metabolism1InformativeInherited
Biological processLipid biosynthesis1InformativeInherited
Biological processProstaglandin biosynthesis0Highly InformativeDirect
Biological processSteroid biosynthesis0Highly InformativeDirect
Biological processGrowth regulation0.00000000008564Highly InformativeDirect
Biological processAntibiotic biosynthesis0.000000004435Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentMicrosome0Highly InformativeDirect
Coding sequence diversityPolymorphism0.000002724Moderately InformativeDirect
DiseaseDisease mutation0.0001306Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
DomainTransit peptide0.0000007463Moderately InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionIron0Moderately InformativeDirect
Molecular functionHeme0InformativeDirect
Molecular functionNADP0InformativeDirect
Molecular functionLipid-binding0.3736InformativeInherited
Molecular functionSteroid-binding0.0000000052Highly InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationMonooxygenase0Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

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UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)lipid metabolism0Least InformativeDirect
UniPathway (UP)aromatic compound metabolism0.7338Least InformativeInherited
UniPathway (UP)secondary metabolite metabolism0Moderately InformativeDirect
UniPathway (UP)alcohol metabolism0Moderately InformativeDirect
UniPathway (UP)aromatic compound biosynthesis0.000000000229Moderately InformativeDirect
UniPathway (UP)nitrogen metabolism0.00002175Moderately InformativeDirect
UniPathway (UP)fatty acid metabolism1Moderately InformativeInherited
UniPathway (UP)lipid biosynthesis1Moderately InformativeInherited
UniPathway (UP)antibiotic biosynthesis0InformativeDirect
UniPathway (UP)alkaloid metabolism0InformativeDirect
UniPathway (UP)terpene metabolism0InformativeDirect
UniPathway (UP)alcohol biosynthesis0InformativeDirect
UniPathway (UP)phenylpropanoid biosynthesis0InformativeDirect
UniPathway (UP)toxin biosynthesis4.527e-16InformativeDirect
UniPathway (UP)pigment biosynthesis0.0008778InformativeDirect
UniPathway (UP)hormone biosynthesis0.004211InformativeInherited
UniPathway (UP)plant hormone metabolism0.4949InformativeInherited
UniPathway (UP)flavonoid metabolism0.9852InformativeInherited
UniPathway (UP)mycotoxin biosynthesis0Highly InformativeDirect
UniPathway (UP)oxylipin biosynthesis0.00000000001041Highly InformativeDirect
UniPathway (UP)anthocyanin biosynthesis0.0000000006136Highly InformativeDirect
UniPathway (UP)erythromycin biosynthesis0.0006821Highly InformativeDirect
UniPathway (UP)steroid hormone biosynthesis0.1379Highly InformativeInherited
UniPathway (UP)monoterpene metabolism0.5762Highly InformativeInherited
UniPathway (UP)plant hormone biosynthesis0.8317Highly InformativeInherited

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR001128 SSF48264 Protein matches
Abstract

More information about these proteins can be found at Protein of the Month: Cytochrome P450.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 23 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Cytochrome P450 domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 23 hidden Markov models representing the Cytochrome P450 superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]