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DNA repair protein MutS, domain III superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   DNA repair protein MutS, domain III [ 48333]
Superfamily:   DNA repair protein MutS, domain III [ 48334]
Families:   DNA repair protein MutS, domain III [ 48335]


Superfamily statistics
Genomes (2,695) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 6,601 30,751 8
Proteins 6,570 30,663 8


Functional annotation
General category coiled coil
Detailed category This is a complex coiled arrangement. The details of which will appear on this page shortly (some coiled coil details are being checked before they are included on the site). If you want to see examples of the states please click here here. If you require further details urgently please contact Owen Rackham

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0 Least Informative Direct
Biological Process (BP) cellular nitrogen compound metabolic process 0 Least Informative Direct
Biological Process (BP) macromolecule metabolic process 0.000000003741 Least Informative Direct
Biological Process (BP) primary metabolic process 0 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0.00000000476 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.000000000003268 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0 Least Informative Direct
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.8293 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.9147 Least Informative Inherited
Biological Process (BP) reproduction 0.00000000000001254 Moderately Informative Direct
Biological Process (BP) organelle organization 0 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 0.00006827 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.008028 Moderately Informative Inherited
Biological Process (BP) immune system process 0.0366 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.001029 Moderately Informative Inherited
Biological Process (BP) DNA metabolic process 0 Informative Direct
Biological Process (BP) cellular response to DNA damage stimulus 0 Informative Direct
Biological Process (BP) cell cycle process 0.000000000000212 Informative Direct
Biological Process (BP) single organism reproductive process 0 Informative Direct
Biological Process (BP) chromosome organization 0.000001397 Informative Direct
Biological Process (BP) nuclear division 0 Highly Informative Direct
Biological Process (BP) regulation of DNA metabolic process 0.000000000000001925 Highly Informative Direct
Biological Process (BP) meiotic cell cycle 0.0000000000004029 Highly Informative Direct
Biological Process (BP) DNA recombination 0.001123 Highly Informative Inherited
Biological Process (BP) nuclear chromosome segregation 0.08251 Highly Informative Inherited
Molecular Function (MF) binding 0.000000256 Least Informative Direct
Molecular Function (MF) hydrolase activity 0.0241 Least Informative Inherited
Molecular Function (MF) nucleic acid binding 0.00007848 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.000002388 Moderately Informative Direct
Molecular Function (MF) anion binding 0.0003167 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0.008987 Moderately Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 0.00128 Moderately Informative Inherited
Molecular Function (MF) DNA binding 0 Informative Direct
Molecular Function (MF) ATPase activity 0.00000002862 Informative Direct
Molecular Function (MF) purine nucleotide binding 0.0000005164 Informative Direct
Molecular Function (MF) ribonucleotide binding 0.0000006297 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.0000001582 Informative Direct
Molecular Function (MF) double-stranded DNA binding 0.00003905 Highly Informative Direct
Molecular Function (MF) ATP binding 0.000000007672 Highly Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.000002891 Least Informative Direct
Cellular Component (CC) protein complex 0.0000004097 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.001137 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.342 Least Informative Inherited
Cellular Component (CC) nuclear part 0.00000232 Moderately Informative Direct
Cellular Component (CC) chromosome 0.0000001857 Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDNA damage0Moderately InformativeDirect
Biological processDNA repair0.00000001705InformativeDirect
Biological processMeiosis0.0000000664InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Post-translational modificationHydrolase0.4375Least InformativeInherited
Post-translational modificationNuclease0Moderately InformativeDirect
Post-translational modificationDNA-binding0Moderately InformativeDirect
Post-translational modificationEndonuclease0InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR007696 SSF48334 Protein matches
Abstract

This domain is found in proteins of the MutS family (DNA mismatch repair proteins) and is found associated with MutS_V, MutS_II, MutS_I and MutS_IV. The MutS family of proteins is named after the Salmonella typhimurium MutS protein involved in mismatch repair; other members of the family included the eukaryotic MSH 1, 2, 3, 4, 5 and 6 proteins. These have various roles in DNA repair and recombination. Human MSH has been implicated in non-polyposis colorectal carcinoma (HNPCC) and is a mismatch binding protein. The aligned region corresponds with domain III, which is central to the structure of Thermus aquaticus MutS.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a DNA repair protein MutS, domain III domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the DNA repair protein MutS, domain III superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]