SUPERFAMILY 1.75 HMM library and genome assignments server


GTPase activation domain, GAP superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   GTPase activation domain, GAP [ 48349]
Superfamily:   GTPase activation domain, GAP [ 48350] (2)
Families:   BCR-homology GTPase activation domain (BH-domain) [ 48351] (5)
  p120GAP domain-like [ 48360] (2)


Superfamily statistics
Genomes (495) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 14,741 16,705 10
Proteins 14,582 16,608 10


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process0.00020420.0000000001208Least InformativeDirect
Biological Process (BP)regulation of metabolic process0.26110.003191Least InformativeInherited
Biological Process (BP)single-organism cellular process0.092570Least InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.00013270.000000006004Moderately InformativeDirect
Biological Process (BP)positive regulation of molecular function0.000010550Moderately InformativeDirect
Biological Process (BP)regulation of catalytic activity0.000056410Moderately InformativeDirect
Biological Process (BP)regulation of signal transduction0.05530Moderately InformativeInherited
Biological Process (BP)regulation of phosphate metabolic process10Moderately InformativeInherited
Biological Process (BP)cellular component movement0.00038510.00000000004741InformativeDirect
Biological Process (BP)regulation of nucleoside metabolic process0.000000033590InformativeDirect
Biological Process (BP)regulation of cellular catabolic process0.00000046090InformativeDirect
Biological Process (BP)locomotion0.000061150InformativeDirect
Biological Process (BP)positive regulation of hydrolase activity0.00000017810InformativeDirect
Biological Process (BP)regulation of purine nucleotide metabolic process0.00000011760InformativeDirect
Biological Process (BP)regulation of Rho GTPase activity0.0000000000099520.00000000005299Highly InformativeDirect
Biological Process (BP)positive regulation of Ras GTPase activity0.00000000010550.000000001537Highly InformativeDirect
Molecular Function (MF)enzyme regulator activity0.0000041240Moderately InformativeDirect
Molecular Function (MF)GTPase regulator activity0.0000000036720InformativeDirect
Molecular Function (MF)enzyme activator activity0.015070InformativeInherited
Molecular Function (MF)small GTPase regulator activity0.000000000048940.0000001399Highly InformativeDirect
Molecular Function (MF)GTPase activator activity0.0014510Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0.000000000000129 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.0000000001208 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.003191 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) localization 0.001842 Least Informative Inherited
Biological Process (BP) signal transduction 0 Moderately Informative Direct
Biological Process (BP) nervous system development 0.00002493 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.0000000000002349 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.000000006004 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.0001198 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 0 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 0.0000003064 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.0000000008014 Moderately Informative Direct
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.05143 Moderately Informative Inherited
Biological Process (BP) system process 0.7289 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.6206 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) immune system process 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) lipid biosynthetic process 0.5887 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.8956 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.01649 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 0.07285 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.1256 Moderately Informative Inherited
Biological Process (BP) phospholipid metabolic process 0.00000009334 Informative Direct
Biological Process (BP) cellular component movement 0.00000000004741 Informative Direct
Biological Process (BP) cytoskeleton organization 0 Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 0 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.0000001782 Informative Direct
Biological Process (BP) actin filament-based process 0 Informative Direct
Biological Process (BP) cell projection organization 0.0000000008251 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.0003145 Informative Direct
Biological Process (BP) intracellular signal transduction 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) regulation of locomotion 0.000000000003845 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.0000001622 Informative Direct
Biological Process (BP) glycerolipid metabolic process 0.000000001614 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0.000004209 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.00000000000004241 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0 Informative Direct
Biological Process (BP) localization of cell 0.000000008233 Informative Direct
Biological Process (BP) regulation of nervous system development 0.000000002361 Informative Direct
Biological Process (BP) regulation of cell development 0.00000000005936 Informative Direct
Biological Process (BP) epithelium development 0.00002794 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0.00000001988 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0 Informative Direct
Biological Process (BP) regulation of response to external stimulus 1 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.9946 Informative Inherited
Biological Process (BP) regulation of establishment of protein localization 0.1481 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 1 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.4566 Informative Inherited
Biological Process (BP) cell-cell signaling 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.1232 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.714 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.4704 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.3954 Informative Inherited
Biological Process (BP) transmission of nerve impulse 0.9334 Informative Inherited
Biological Process (BP) regulation of response to stress 1 Informative Inherited
Biological Process (BP) regulation of cell proliferation 1 Informative Inherited
Biological Process (BP) dephosphorylation 0.0481 Informative Inherited
Biological Process (BP) phosphorylation 0.9272 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.2075 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.7141 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.06243 Informative Inherited
Biological Process (BP) negative regulation of cell death 0.7665 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.003121 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) regulation of secretion 1 Informative Inherited
Biological Process (BP) regulation of immune effector process 0.1913 Informative Inherited
Biological Process (BP) growth 0.007813 Informative Inherited
Biological Process (BP) single-organism behavior 0.08027 Informative Inherited
Biological Process (BP) regulation of growth 0.8578 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.4725 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.9893 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.205 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.2352 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.6393 Informative Inherited
Biological Process (BP) response to organonitrogen compound 0.05891 Informative Inherited
Biological Process (BP) biological adhesion 0.001459 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 1 Informative Inherited
Biological Process (BP) generation of neurons 0.12 Informative Inherited
Biological Process (BP) central nervous system development 0.0125 Informative Inherited
Biological Process (BP) tube development 0.03693 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.1994 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.3212 Informative Inherited
Biological Process (BP) organ morphogenesis 0.009791 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.07423 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.9759 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.6073 Informative Inherited
Biological Process (BP) cardiovascular system development 0.4021 Informative Inherited
Biological Process (BP) cell cycle process 0.3271 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.1388 Informative Inherited
Biological Process (BP) chemotaxis 0.00000000000001761 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.0001732 Highly Informative Direct
Biological Process (BP) small GTPase mediated signal transduction 0 Highly Informative Direct
Biological Process (BP) learning or memory 0.0002245 Highly Informative Direct
Biological Process (BP) regulation of striated muscle tissue development 0.0005238 Highly Informative Direct
Biological Process (BP) telencephalon development 0.0005149 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 0.0001382 Highly Informative Direct
Biological Process (BP) lipid modification 0.00000001618 Highly Informative Direct
Biological Process (BP) regulation of Rho GTPase activity 0.00000000005299 Highly Informative Direct
Biological Process (BP) positive regulation of Ras GTPase activity 0.000000001537 Highly Informative Direct
Biological Process (BP) cell junction organization 0.00007805 Highly Informative Direct
Biological Process (BP) limb morphogenesis 0.00002305 Highly Informative Direct
Biological Process (BP) negative regulation of locomotion 0.0000000000001028 Highly Informative Direct
Biological Process (BP) regulation of neuron apoptotic process 0.00004197 Highly Informative Direct
Biological Process (BP) phosphatidylinositol metabolic process 0.000000000000003722 Highly Informative Direct
Biological Process (BP) post-embryonic organ development 0.0001021 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in neuron differentiation 0.0004528 Highly Informative Direct
Biological Process (BP) cell projection morphogenesis 0.00000005566 Highly Informative Direct
Biological Process (BP) negative regulation of cellular component movement 0.0000000000034 Highly Informative Direct
Biological Process (BP) cell division 0.0001438 Highly Informative Direct
Biological Process (BP) neural precursor cell proliferation 0.0007406 Highly Informative Direct
Biological Process (BP) negative regulation of neuron death 0.0006119 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.002659 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.0631 Highly Informative Inherited
Biological Process (BP) regulation of behavior 1 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular transport 0.02187 Highly Informative Inherited
Biological Process (BP) regulation of intracellular protein transport 0.6772 Highly Informative Inherited
Biological Process (BP) negative regulation of protein transport 0.6433 Highly Informative Inherited
Biological Process (BP) renal system development 0.1389 Highly Informative Inherited
Biological Process (BP) epithelial cell development 0.5707 Highly Informative Inherited
Biological Process (BP) regulation of ERK1 and ERK2 cascade 0.2576 Highly Informative Inherited
Biological Process (BP) neuromuscular process 0.09341 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 0.2432 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.06572 Highly Informative Inherited
Biological Process (BP) negative regulation of growth 0.01355 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.03791 Highly Informative Inherited
Biological Process (BP) leukocyte migration 0.005064 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 0.5869 Highly Informative Inherited
Biological Process (BP) regulation of nucleocytoplasmic transport 0.01371 Highly Informative Inherited
Biological Process (BP) regulation of proteolysis 0.01408 Highly Informative Inherited
Biological Process (BP) circadian rhythm 0.02314 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.5528 Highly Informative Inherited
Biological Process (BP) negative regulation of apoptotic process 0.2098 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.1348 Highly Informative Inherited
Biological Process (BP) negative regulation of secretion 0.04519 Highly Informative Inherited
Biological Process (BP) regulation of protein localization to nucleus 0.2572 Highly Informative Inherited
Biological Process (BP) cell growth 0.01002 Highly Informative Inherited
Biological Process (BP) developmental growth 0.7377 Highly Informative Inherited
Biological Process (BP) regulation of multicellular organism growth 0.1579 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.02783 Highly Informative Inherited
Biological Process (BP) response to peptide hormone stimulus 0.009083 Highly Informative Inherited
Biological Process (BP) cellular response to peptide 0.001574 Highly Informative Inherited
Biological Process (BP) cell adhesion 0.1696 Highly Informative Inherited
Biological Process (BP) regulation of actin cytoskeleton organization 0.4965 Highly Informative Inherited
Biological Process (BP) regulation of protein complex assembly 0.2762 Highly Informative Inherited
Biological Process (BP) regulation of cyclic nucleotide metabolic process 1 Highly Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 0.04597 Highly Informative Inherited
Biological Process (BP) axon development 0.3596 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 0.002806 Highly Informative Inherited
Biological Process (BP) epithelial tube formation 0.00313 Highly Informative Inherited
Molecular Function (MF) binding 0.00002273 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) enzyme regulator activity 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.00003086 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0.9052 Moderately Informative Inherited
Molecular Function (MF) enzyme activator activity 0 Informative Direct
Molecular Function (MF) lipid binding 0.000003152 Informative Direct
Molecular Function (MF) enzyme binding 0.0000000003991 Informative Direct
Molecular Function (MF) GTPase regulator activity 0 Informative Direct
Molecular Function (MF) phosphoric ester hydrolase activity 0.1155 Informative Inherited
Molecular Function (MF) kinase activity 1 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 1 Informative Inherited
Molecular Function (MF) receptor activity 0.001204 Informative Inherited
Molecular Function (MF) receptor binding 0.3968 Informative Inherited
Molecular Function (MF) molecular transducer activity 0.002384 Informative Inherited
Molecular Function (MF) nucleoside-triphosphatase activity 0.3495 Informative Inherited
Molecular Function (MF) small GTPase regulator activity 0.0000001399 Highly Informative Direct
Molecular Function (MF) GTPase activator activity 0 Highly Informative Direct
Molecular Function (MF) Ras GTPase binding 0 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0.0000093 Highly Informative Direct
Molecular Function (MF) phosphatidylinositol binding 0.2955 Highly Informative Inherited
Molecular Function (MF) protein complex binding 0.02698 Highly Informative Inherited
Cellular Component (CC) membrane 0.000498 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.0000006849 Least Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.2605 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cytosol 0 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.00000002055 Moderately Informative Direct
Cellular Component (CC) cell projection 0.00000000004852 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.001835 Moderately Informative Inherited
Cellular Component (CC) cell cortex 0.0000000000000178 Informative Direct
Cellular Component (CC) actin cytoskeleton 0.00007602 Informative Direct
Cellular Component (CC) cell leading edge 0 Informative Direct
Cellular Component (CC) synapse part 0.0008336 Informative Direct
Cellular Component (CC) neuron projection 0.9355 Informative Inherited
Cellular Component (CC) cell-cell junction 1 Informative Inherited
Cellular Component (CC) ruffle 0.00000001577 Highly Informative Direct
Cellular Component (CC) actin filament 0.0007496 Highly Informative Direct
Cellular Component (CC) lateral plasma membrane 0.00000008307 Highly Informative Direct
Cellular Component (CC) midbody 0.0008847 Highly Informative Direct
Cellular Component (CC) cell division site part 0.00000000009015 Highly Informative Direct
Cellular Component (CC) contractile ring 0.00001195 Highly Informative Direct
Cellular Component (CC) receptor complex 0.02862 Highly Informative Inherited

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.4446Least InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.4341Moderately InformativeInherited
Disease Ontology (DO)polycythemia0.0005642Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Somatic mutation0.0004169Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.5899Least InformativeInherited
Phenotypic Abnormality (PA)Behavioral abnormality0.3347InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.4151InformativeInherited
Phenotypic Abnormality (PA)Short attention span0.0013Highly InformativeInherited
Phenotypic Abnormality (PA)Hyperactivity0.005578Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.02716Least InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.05341Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.2066Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.5546Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.7394Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.7664Moderately InformativeInherited
Mammalian Phenotype (MP)ectopic neuron0.018InformativeInherited
Mammalian Phenotype (MP)abnormal metencephalon morphology0.896InformativeInherited
Mammalian Phenotype (MP)ectopic cerebellar granule cells0.00002205Highly InformativeDirect
Mammalian Phenotype (MP)abnormal amacrine cell morphology0.0003264Highly InformativeDirect
Mammalian Phenotype (MP)abnormal ear development0.0009557Highly InformativeDirect
Mammalian Phenotype (MP)abnormal glial cell physiology0.03508Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.1217Least InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.03338Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.0817InformativeInherited
Worm Phenotype (WP)cleavage furrow defective early emb0.0000701Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)nervous system0.3973Least InformativeInherited
Zebrafish Anatomy (ZA)cavitated compound organ0.5083Least InformativeInherited
Zebrafish Anatomy (ZA)central nervous system0.1208Moderately InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.002546Least InformativeInherited
Enzyme Commission (EC)Transferring phosphorous-containing groups0.0314Least InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0.000000001447Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.00001176Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0.000002999InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation0.0000005052Moderately InformativeDirect
Biological processEndocytosis0InformativeDirect
Biological processNeurogenesis0InformativeDirect
Biological processAngiogenesis0.000000000001782InformativeDirect
Cellular componentMembrane0.0000000000003584Least InformativeDirect
Cellular componentCytoplasm0.04075Least InformativeInherited
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle6.421e-16Moderately InformativeDirect
Cellular componentEndosome0.0000000002111Moderately InformativeDirect
Cellular componentCytoskeleton0.0000000005323Moderately InformativeDirect
Cellular componentGolgi apparatus0.0000001727Moderately InformativeDirect
Coding sequence diversityAlternative splicing0.000001243Least InformativeDirect
DiseaseTumor suppressor0.0000000001088Moderately InformativeDirect
DomainRepeat0.000002533Least InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
DomainZinc-finger0.0000009423Moderately InformativeDirect
DomainSH2 domain0InformativeDirect
DomainSH3 domain0InformativeDirect
DomainSH3-binding0.00000000000006417InformativeDirect
DomainLIM domain0.00003112Highly InformativeDirect
Molecular functionZinc0.00001042Least InformativeDirect
Molecular functionCalmodulin-binding0.000000008619InformativeDirect
Molecular functionActin-binding0.0002071InformativeDirect
Post-translational modificationDevelopmental protein0.0000000000196Moderately InformativeDirect
Post-translational modificationReceptor0.00002149Moderately InformativeDirect
Post-translational modificationGTPase activation0InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor0InformativeDirect
Post-translational modificationMyosin0.0000001293Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR008936 SSF48350 Protein matches
Abstract

Proteins containing a RhoGAP (Rho GTPase Activating Protein) domain usually function to catalyze the hydrolysis of GTP that is bound to Rho, Rac and/or Cdc42, inactivating these regulators of the actin cytoskeleton. The 53 known human RhoGAP domain-containing proteins are the largest known group of Rho GTPase regulators and significantly outnumber the 21 Rho GTPases they presumably regulate. This excess of GAP proteins probably indicates complex regulation of the Rho GTPases and is consistent with the existence of almost as many (48) human Dbl domain-containing Rho GEFs that act antagonistically to the RhoGAP proteins by activating the Rho GTPases. Phylogenetic analysis offers evidence for frequent domain duplication and for duplication of the entire genes containing these GAP domains [PubMed12297274].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 6 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a GTPase activation domain, GAP domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 6 hidden Markov models representing the GTPase activation domain, GAP superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


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