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GTPase activation domain, GAP superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   GTPase activation domain, GAP [ 48349]
Superfamily:   GTPase activation domain, GAP [ 48350] (2)
Families:   BCR-homology GTPase activation domain (BH-domain) [ 48351] (5)
  p120GAP domain-like [ 48360] (2)


Superfamily statistics
Genomes (514) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 15,816 0 10
Proteins 15,662 0 10


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)hematopoietic system disease0.3635Moderately InformativeInherited
Disease Ontology (DO)bone marrow disease0.000616Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Somatic mutation0.0006034InformativeDirect
Phenotypic Abnormality (PA)Abnormality of limbs0.00957Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper limb0.0005664Moderately InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.1Least InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.0295Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.1358Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cerebral hemisphere morphology0.0009672InformativeDirect
Mammalian Phenotype (MP)abnormal metencephalon morphology0.879InformativeInherited
Mammalian Phenotype (MP)ectopic cerebellar granule cells0.000002071Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell morphology variant0.000114Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.0002312Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.004529Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.1854Least InformativeInherited
Worm Phenotype (WP)protein expression variant0.0001089Moderately InformativeDirect
Worm Phenotype (WP)early embryonic lethal0.03422Moderately InformativeInherited
Worm Phenotype (WP)cell component morphology variant0.328Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.6369Moderately InformativeInherited
Worm Phenotype (WP)muscle cell physiology variant0.0002474InformativeDirect
Worm Phenotype (WP)cytokinesis variant emb0.001644InformativeInherited
Worm Phenotype (WP)mitochondria morphology variant0.06437InformativeInherited
Worm Phenotype (WP)mitochondria alignment variant0.00001103Highly InformativeDirect
Worm Phenotype (WP)cleavage furrow defective0.00007993Highly InformativeDirect
Worm Phenotype (WP)cytokinesis defective early emb0.004799Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0.3494Least InformativeInherited
Zebrafish Anatomy (ZA)nervous system0.4553Least InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.7448Moderately InformativeInherited
Zebrafish Anatomy (ZA)electrically signaling cell0.06931InformativeInherited
Zebrafish Anatomy (ZA)electrically responsive cell1InformativeInherited
Zebrafish Anatomy (ZA)primary motor neuron0.0001423Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.002732Least InformativeInherited
Enzyme Commission (EC)Transferring phosphorus-containing groups0.02868Least InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0.000000001303Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.00001343Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0.000003749InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation0.00000004632Moderately InformativeDirect
Biological processEndocytosis0InformativeDirect
Biological processNeurogenesis0InformativeDirect
Biological processAngiogenesis0.000000000002814InformativeDirect
Biological processStress response0.0007148InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCytoplasm0.0001403Least InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.00000000000004316Moderately InformativeDirect
Cellular componentCytoskeleton0.00000000001171Moderately InformativeDirect
Cellular componentEndosome0.000000005174Moderately InformativeDirect
Cellular componentGolgi apparatus0.000002913Moderately InformativeDirect
Coding sequence diversityAlternative splicing0.000001098Least InformativeDirect
DiseaseTumor suppressor0.000000013Moderately InformativeDirect
DomainRepeat0.000007506Least InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
DomainZinc-finger0.000001054Moderately InformativeDirect
DomainSH2 domain0InformativeDirect
DomainSH3 domain0InformativeDirect
DomainSH3-binding0.000000000000002154InformativeDirect
DomainLIM domain0.00003339Highly InformativeDirect
Molecular functionZinc0.00004253Least InformativeDirect
Molecular functionLipid-binding0.0000003644Moderately InformativeDirect
Post-translational modificationDevelopmental protein0.00000000002838Moderately InformativeDirect
Post-translational modificationReceptor0.00001995Moderately InformativeDirect
Post-translational modificationGTPase activation0InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor0InformativeDirect
Post-translational modificationCalmodulin-binding0.00000003745InformativeDirect
Post-translational modificationActin-binding0.0004989InformativeDirect
Post-translational modificationMyosin0.0000001298Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR008936 SSF48350 Protein matches
Abstract

Proteins containing a RhoGAP (Rho GTPase Activating Protein) domain usually function to catalyze the hydrolysis of GTP that is bound to Rho, Rac and/or Cdc42, inactivating these regulators of the actin cytoskeleton. The 53 known human RhoGAP domain-containing proteins are the largest known group of Rho GTPase regulators and significantly outnumber the 21 Rho GTPases they presumably regulate. This excess of GAP proteins probably indicates complex regulation of the Rho GTPases and is consistent with the existence of almost as many (48) human Dbl domain-containing Rho GEFs that act antagonistically to the RhoGAP proteins by activating the Rho GTPases. Phylogenetic analysis offers evidence for frequent domain duplication and for duplication of the entire genes containing these GAP domains [PubMed12297274].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 6 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a GTPase activation domain, GAP domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 6 hidden Markov models representing the GTPase activation domain, GAP superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]