SUPERFAMILY 1.75 HMM library and genome assignments server

Please note: Superfamily is currently under maintenance and some functionality may be limited. Please bear with us as we fix these problems.


GTPase activation domain, GAP superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   GTPase activation domain, GAP [ 48349]
Superfamily:   GTPase activation domain, GAP [ 48350] (2)
Families:   BCR-homology GTPase activation domain (BH-domain) [ 48351] (5)
  p120GAP domain-like [ 48360] (2)


Superfamily statistics
Genomes (506) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 15,408 16,705 10
Proteins 15,253 16,608 10


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process0.00025910.00000000008402Least InformativeDirect
Biological Process (BP)regulation of metabolic process0.25480.002649Least InformativeInherited
Biological Process (BP)single-organism cellular process0.091760Least InformativeInherited
Biological Process (BP)positive regulation of molecular function0.000010230Moderately InformativeDirect
Biological Process (BP)regulation of catalytic activity0.000057440Moderately InformativeDirect
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.00014870.000000003289Moderately InformativeDirect
Biological Process (BP)regulation of signal transduction0.052210Moderately InformativeInherited
Biological Process (BP)regulation of phosphate metabolic process10Moderately InformativeInherited
Biological Process (BP)regulation of nucleoside metabolic process0.000000027290InformativeDirect
Biological Process (BP)regulation of purine nucleotide metabolic process0.00000010070InformativeDirect
Biological Process (BP)positive regulation of hydrolase activity0.00000015070InformativeDirect
Biological Process (BP)regulation of cellular catabolic process0.00000046650InformativeDirect
Biological Process (BP)locomotion0.000063460InformativeDirect
Biological Process (BP)cellular component movement0.00035490.00000000004761InformativeDirect
Biological Process (BP)regulation of Rho protein signal transduction0.000000000029540.00000000003645Highly InformativeDirect
Biological Process (BP)regulation of Ras GTPase activity0.00000000021470.000000001103Highly InformativeDirect
Biological Process (BP)positive regulation of GTPase activity0.0000000045130Highly InformativeDirect
Molecular Function (MF)enzyme regulator activity0.00000460Moderately InformativeDirect
Molecular Function (MF)GTPase regulator activity0.0000000040950InformativeDirect
Molecular Function (MF)enzyme activator activity0.015360InformativeInherited
Molecular Function (MF)small GTPase regulator activity0.000000000056590.0000001173Highly InformativeDirect
Molecular Function (MF)GTPase activator activity0.0015030Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 0.00000000008402 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.000000000000278 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.002649 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) localization 0.00175 Least Informative Inherited
Biological Process (BP) positive regulation of molecular function 0 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.000000003289 Moderately Informative Direct
Biological Process (BP) signal transduction 0 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.00000000000007996 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.0000000005237 Moderately Informative Direct
Biological Process (BP) nervous system development 0.00001363 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.0001751 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.01448 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.06097 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.9595 Moderately Informative Inherited
Biological Process (BP) system process 0.7448 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.4704 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) immune system process 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.8478 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.3528 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.1427 Moderately Informative Inherited
Biological Process (BP) regulation of nucleoside metabolic process 0 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) cellular component movement 0.00000000004761 Informative Direct
Biological Process (BP) cytoskeleton organization 0 Informative Direct
Biological Process (BP) actin filament-based process 0 Informative Direct
Biological Process (BP) intracellular signal transduction 0 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.00000000000004119 Informative Direct
Biological Process (BP) regulation of locomotion 0.000000000004037 Informative Direct
Biological Process (BP) regulation of cell development 0.00000000001474 Informative Direct
Biological Process (BP) regulation of nervous system development 0.0000000003293 Informative Direct
Biological Process (BP) cell projection organization 0.000000000385 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0.000000001934 Informative Direct
Biological Process (BP) glycerolipid metabolic process 0.000000002152 Informative Direct
Biological Process (BP) localization of cell 0.00000001159 Informative Direct
Biological Process (BP) phospholipid metabolic process 0.0000001075 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.0000001106 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.0000001244 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0.000001579 Informative Direct
Biological Process (BP) epithelium development 0.00002755 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.0002059 Informative Direct
Biological Process (BP) regulation of response to external stimulus 1 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.9992 Informative Inherited
Biological Process (BP) regulation of protein localization 0.7362 Informative Inherited
Biological Process (BP) organelle assembly 0.8054 Informative Inherited
Biological Process (BP) cell cycle process 0.3181 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.1383 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 1 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.4607 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.07365 Informative Inherited
Biological Process (BP) microtubule-based process 0.4578 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.3258 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.562 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.2742 Informative Inherited
Biological Process (BP) synaptic transmission 0.003466 Informative Inherited
Biological Process (BP) regulation of defense response 0.8852 Informative Inherited
Biological Process (BP) regulation of cell proliferation 1 Informative Inherited
Biological Process (BP) dephosphorylation 0.0583 Informative Inherited
Biological Process (BP) phosphorylation 0.9246 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.2141 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.05058 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.7322 Informative Inherited
Biological Process (BP) negative regulation of cell death 0.8399 Informative Inherited
Biological Process (BP) negative regulation of transport 0.02015 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.1626 Informative Inherited
Biological Process (BP) regulation of secretion 1 Informative Inherited
Biological Process (BP) regulation of immune effector process 0.203 Informative Inherited
Biological Process (BP) regulation of cell activation 1 Informative Inherited
Biological Process (BP) regulation of vesicle-mediated transport 0.2457 Informative Inherited
Biological Process (BP) growth 0.01951 Informative Inherited
Biological Process (BP) single-organism behavior 0.08276 Informative Inherited
Biological Process (BP) regulation of growth 0.8694 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.5484 Informative Inherited
Biological Process (BP) response to organonitrogen compound 0.06764 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.2348 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.2396 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.645 Informative Inherited
Biological Process (BP) response to hormone stimulus 1 Informative Inherited
Biological Process (BP) biological adhesion 0.001811 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.03667 Informative Inherited
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) generation of neurons 0.08732 Informative Inherited
Biological Process (BP) central nervous system development 0.01482 Informative Inherited
Biological Process (BP) tube development 0.03408 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.1994 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.3262 Informative Inherited
Biological Process (BP) organ morphogenesis 0.008945 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.1253 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.9981 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.5569 Informative Inherited
Biological Process (BP) cardiovascular system development 0.3918 Informative Inherited
Biological Process (BP) regulation of Rho protein signal transduction 0.00000000003645 Highly Informative Direct
Biological Process (BP) regulation of Ras GTPase activity 0.000000001103 Highly Informative Direct
Biological Process (BP) positive regulation of GTPase activity 0 Highly Informative Direct
Biological Process (BP) small GTPase mediated signal transduction 0 Highly Informative Direct
Biological Process (BP) chemotaxis 0.000000000000003755 Highly Informative Direct
Biological Process (BP) phosphatidylinositol metabolic process 0.000000000000005594 Highly Informative Direct
Biological Process (BP) negative regulation of locomotion 0.0000000000001995 Highly Informative Direct
Biological Process (BP) negative regulation of cellular component movement 0.000000000005936 Highly Informative Direct
Biological Process (BP) cell part morphogenesis 0.00000000267 Highly Informative Direct
Biological Process (BP) lipid modification 0.00000002156 Highly Informative Direct
Biological Process (BP) limb morphogenesis 0.00002535 Highly Informative Direct
Biological Process (BP) regulation of neuron apoptotic process 0.00004307 Highly Informative Direct
Biological Process (BP) neural tube development 0.00005355 Highly Informative Direct
Biological Process (BP) cell junction organization 0.00007293 Highly Informative Direct
Biological Process (BP) post-embryonic organ development 0.00009439 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.0001093 Highly Informative Direct
Biological Process (BP) regulation of striated muscle cell differentiation 0.0001194 Highly Informative Direct
Biological Process (BP) cell division 0.000152 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 0.000198 Highly Informative Direct
Biological Process (BP) learning or memory 0.0002361 Highly Informative Direct
Biological Process (BP) telencephalon development 0.0006096 Highly Informative Direct
Biological Process (BP) neural precursor cell proliferation 0.0006587 Highly Informative Direct
Biological Process (BP) negative regulation of neuron death 0.000683 Highly Informative Direct
Biological Process (BP) regulation of striated muscle tissue development 0.0007849 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.002341 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.02643 Highly Informative Inherited
Biological Process (BP) regulation of behavior 1 Highly Informative Inherited
Biological Process (BP) neuron projection development 0.001131 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular transport 0.02104 Highly Informative Inherited
Biological Process (BP) negative regulation of protein transport 0.6311 Highly Informative Inherited
Biological Process (BP) regulation of intracellular protein transport 0.6497 Highly Informative Inherited
Biological Process (BP) spindle organization 0.07885 Highly Informative Inherited
Biological Process (BP) mitosis 0.3454 Highly Informative Inherited
Biological Process (BP) renal system development 0.1356 Highly Informative Inherited
Biological Process (BP) epithelial cell development 0.5727 Highly Informative Inherited
Biological Process (BP) neuromuscular process 0.09859 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 0.2741 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.07247 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.003165 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.02647 Highly Informative Inherited
Biological Process (BP) leukocyte migration 0.005174 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 0.6551 Highly Informative Inherited
Biological Process (BP) regulation of nucleocytoplasmic transport 0.01436 Highly Informative Inherited
Biological Process (BP) regulation of proteolysis 0.01609 Highly Informative Inherited
Biological Process (BP) circadian rhythm 0.02761 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.5646 Highly Informative Inherited
Biological Process (BP) negative regulation of apoptotic process 0.2117 Highly Informative Inherited
Biological Process (BP) negative regulation of leukocyte activation 0.01071 Highly Informative Inherited
Biological Process (BP) regulation of exocytosis 0.03367 Highly Informative Inherited
Biological Process (BP) negative regulation of secretion 0.04031 Highly Informative Inherited
Biological Process (BP) negative regulation of immune effector process 0.004619 Highly Informative Inherited
Biological Process (BP) regulation of protein localization to nucleus 0.2274 Highly Informative Inherited
Biological Process (BP) cell growth 0.004569 Highly Informative Inherited
Biological Process (BP) developmental growth 0.5609 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.04068 Highly Informative Inherited
Biological Process (BP) regulation of multicellular organism growth 0.1723 Highly Informative Inherited
Biological Process (BP) cellular response to peptide 0.001796 Highly Informative Inherited
Biological Process (BP) response to peptide hormone stimulus 0.01009 Highly Informative Inherited
Biological Process (BP) cell adhesion 0.1817 Highly Informative Inherited
Biological Process (BP) regulation of actin cytoskeleton organization 0.4446 Highly Informative Inherited
Biological Process (BP) regulation of protein complex assembly 0.131 Highly Informative Inherited
Biological Process (BP) regulation of cyclic nucleotide metabolic process 1 Highly Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 0.04681 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 0.002249 Highly Informative Inherited
Biological Process (BP) epithelial tube formation 0.003185 Highly Informative Inherited
Molecular Function (MF) binding 0.000006856 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) enzyme regulator activity 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.00001932 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0.9262 Moderately Informative Inherited
Molecular Function (MF) GTPase regulator activity 0 Informative Direct
Molecular Function (MF) enzyme activator activity 0 Informative Direct
Molecular Function (MF) enzyme binding 0.0000000005659 Informative Direct
Molecular Function (MF) lipid binding 0.000001227 Informative Direct
Molecular Function (MF) receptor activity 0.0005688 Informative Direct
Molecular Function (MF) phosphoric ester hydrolase activity 0.1291 Informative Inherited
Molecular Function (MF) kinase activity 1 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 1 Informative Inherited
Molecular Function (MF) receptor binding 0.418 Informative Inherited
Molecular Function (MF) molecular transducer activity 0.001183 Informative Inherited
Molecular Function (MF) nucleoside-triphosphatase activity 0.3524 Informative Inherited
Molecular Function (MF) small GTPase regulator activity 0.0000001173 Highly Informative Direct
Molecular Function (MF) GTPase activator activity 0 Highly Informative Direct
Molecular Function (MF) Ras GTPase binding 0 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0.000003366 Highly Informative Direct
Molecular Function (MF) phosphatidylinositol binding 0.2561 Highly Informative Inherited
Molecular Function (MF) protein complex binding 0.01418 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 0.000008121 Least Informative Direct
Cellular Component (CC) membrane 0.0005264 Least Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.01191 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) cytosol 0 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.00000000000001332 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.005252 Moderately Informative Inherited
Cellular Component (CC) cell leading edge 0 Informative Direct
Cellular Component (CC) cell cortex 0.00000000000001758 Informative Direct
Cellular Component (CC) actin cytoskeleton 0.000000008046 Informative Direct
Cellular Component (CC) cell junction 0.0000001808 Informative Direct
Cellular Component (CC) neuron projection 0.2918 Informative Inherited
Cellular Component (CC) cell division site part 0.0000000001621 Highly Informative Direct
Cellular Component (CC) growth cone 0.000005108 Highly Informative Direct
Cellular Component (CC) receptor complex 0.02881 Highly Informative Inherited

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.4777Least InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.4376Moderately InformativeInherited
Disease Ontology (DO)polycythemia0.0004633Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Somatic mutation0.0003228Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.5926Least InformativeInherited
Phenotypic Abnormality (PA)Behavioral abnormality0.3332InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.4127InformativeInherited
Phenotypic Abnormality (PA)Short attention span0.001175Highly InformativeInherited
Phenotypic Abnormality (PA)Hyperactivity0.005225Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.02831Least InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.05797Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.212Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.5659Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.7365Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.7823Moderately InformativeInherited
Mammalian Phenotype (MP)ectopic neuron0.01905InformativeInherited
Mammalian Phenotype (MP)abnormal metencephalon morphology0.8972InformativeInherited
Mammalian Phenotype (MP)ectopic cerebellar granule cells0.00002165Highly InformativeDirect
Mammalian Phenotype (MP)abnormal amacrine cell morphology0.000443Highly InformativeDirect
Mammalian Phenotype (MP)abnormal ear development0.0009377Highly InformativeDirect
Mammalian Phenotype (MP)abnormal glial cell physiology0.036Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.1217Least InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.03338Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.0817InformativeInherited
Worm Phenotype (WP)cleavage furrow defective early emb0.0000701Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.002599Least InformativeInherited
Enzyme Commission (EC)Transferring phosphorous-containing groups0.03125Least InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0.000000001441Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.00001179Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0.000003042InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation0.0000005389Moderately InformativeDirect
Biological processEndocytosis0InformativeDirect
Biological processNeurogenesis0InformativeDirect
Biological processAngiogenesis0.000000000001738InformativeDirect
Cellular componentMembrane0.0000000000004116Least InformativeDirect
Cellular componentCytoplasm0.03947Least InformativeInherited
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle6.436e-16Moderately InformativeDirect
Cellular componentEndosome0.0000000002281Moderately InformativeDirect
Cellular componentCytoskeleton0.0000000005463Moderately InformativeDirect
Cellular componentGolgi apparatus0.0000001778Moderately InformativeDirect
Coding sequence diversityAlternative splicing0.0000009702Least InformativeDirect
DiseaseTumor suppressor0.0000000001039Moderately InformativeDirect
DomainRepeat0.000002599Least InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
DomainZinc-finger0.0000008645Moderately InformativeDirect
DomainSH2 domain0InformativeDirect
DomainSH3 domain0InformativeDirect
DomainSH3-binding0.00000000000006165InformativeDirect
DomainLIM domain0.0000304Highly InformativeDirect
Molecular functionZinc0.00001228Least InformativeDirect
Molecular functionCalmodulin-binding0.000000008406InformativeDirect
Molecular functionActin-binding0.0002082InformativeDirect
Post-translational modificationDevelopmental protein0.00000000001835Moderately InformativeDirect
Post-translational modificationReceptor0.00002088Moderately InformativeDirect
Post-translational modificationGTPase activation0InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor0InformativeDirect
Post-translational modificationMyosin0.0000001274Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR008936 SSF48350 Protein matches
Abstract

Proteins containing a RhoGAP (Rho GTPase Activating Protein) domain usually function to catalyze the hydrolysis of GTP that is bound to Rho, Rac and/or Cdc42, inactivating these regulators of the actin cytoskeleton. The 53 known human RhoGAP domain-containing proteins are the largest known group of Rho GTPase regulators and significantly outnumber the 21 Rho GTPases they presumably regulate. This excess of GAP proteins probably indicates complex regulation of the Rho GTPases and is consistent with the existence of almost as many (48) human Dbl domain-containing Rho GEFs that act antagonistically to the RhoGAP proteins by activating the Rho GTPases. Phylogenetic analysis offers evidence for frequent domain duplication and for duplication of the entire genes containing these GAP domains [PubMed12297274].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 6 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a GTPase activation domain, GAP domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 6 hidden Markov models representing the GTPase activation domain, GAP superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]