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GTPase activation domain, GAP superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   GTPase activation domain, GAP [ 48349]
Superfamily:   GTPase activation domain, GAP [ 48350] (2)
Families:   BCR-homology GTPase activation domain (BH-domain) [ 48351] (5)
  p120GAP domain-like [ 48360] (2)


Superfamily statistics
Genomes (512) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 15,618 39,293 10
Proteins 15,464 39,054 10


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Molecular Function (MF)molecular function regulator0.0000000620Moderately InformativeDirect
Molecular Function (MF)enzyme activator activity0.0091670InformativeInherited
Molecular Function (MF)GTPase regulator activity0.000000000000033410Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.00000002505 Least Informative Direct
Biological Process (BP) response to stimulus 0.000000002904 Least Informative Direct
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular developmental process 0.000002258 Moderately Informative Direct
Biological Process (BP) system development 0.00002938 Moderately Informative Direct
Biological Process (BP) regulation of signaling 0 Moderately Informative Direct
Biological Process (BP) single organism signaling 0 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0 Moderately Informative Direct
Biological Process (BP) cell communication 0 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 0 Moderately Informative Direct
Biological Process (BP) regulation of localization 0 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 0.00000000000002463 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.00000000007196 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.0001241 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.79 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.1198 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.5431 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.06109 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.9494 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 1 Moderately Informative Inherited
Biological Process (BP) actin filament-based process 0 Informative Direct
Biological Process (BP) regulation of intracellular signal transduction 0 Informative Direct
Biological Process (BP) positive regulation of transport 0 Informative Direct
Biological Process (BP) cytoskeleton organization 0 Informative Direct
Biological Process (BP) locomotion 0.00000000000005443 Informative Direct
Biological Process (BP) intracellular signal transduction 0.0000000000003912 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0.0000000000004227 Informative Direct
Biological Process (BP) regulation of hydrolase activity 0.000000000000778 Informative Direct
Biological Process (BP) positive regulation of catalytic activity 0.00000000008848 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0.0000000005257 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.00000002046 Informative Direct
Biological Process (BP) regulation of nervous system development 0.00000006753 Informative Direct
Biological Process (BP) regulation of locomotion 0.0000002247 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.0000002346 Informative Direct
Biological Process (BP) glycerolipid metabolic process 0.0000003927 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.000000398 Informative Direct
Biological Process (BP) cell cycle process 0.000004563 Informative Direct
Biological Process (BP) phospholipid metabolic process 0.00000474 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.00002657 Informative Direct
Biological Process (BP) behavior 0.00005666 Informative Direct
Biological Process (BP) animal organ morphogenesis 0.0002696 Informative Direct
Biological Process (BP) cell development 0.0002789 Informative Direct
Biological Process (BP) regulation of apoptotic process 0.0005911 Informative Direct
Biological Process (BP) mitotic cell cycle 0.0006174 Informative Direct
Biological Process (BP) generation of neurons 0.9146 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 1 Informative Inherited
Biological Process (BP) regulation of establishment of protein localization 0.01453 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.003666 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.01923 Informative Inherited
Biological Process (BP) cellular response to hormone stimulus 0.006738 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.3392 Informative Inherited
Biological Process (BP) regulation of protein modification process 0.001045 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.05958 Informative Inherited
Biological Process (BP) regulation of cell differentiation 0.4506 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.5379 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.001965 Informative Inherited
Biological Process (BP) regulation of cell proliferation 1 Informative Inherited
Biological Process (BP) dephosphorylation 0.03381 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.008319 Informative Inherited
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 0.02474 Informative Inherited
Biological Process (BP) regulation of phosphorylation 1 Informative Inherited
Biological Process (BP) regulation of transferase activity 1 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.1123 Informative Inherited
Biological Process (BP) response to nitrogen compound 0.6934 Informative Inherited
Biological Process (BP) regulation of peptide transport 1 Informative Inherited
Biological Process (BP) regulation of cellular localization 1 Informative Inherited
Biological Process (BP) growth 0.0271 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.7478 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.9909 Informative Inherited
Biological Process (BP) negative regulation of molecular function 1 Informative Inherited
Biological Process (BP) positive regulation of gene expression 0.9013 Informative Inherited
Biological Process (BP) regulation of cell cycle 1 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.5442 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.04279 Informative Inherited
Biological Process (BP) phosphorylation 0.02341 Informative Inherited
Biological Process (BP) central nervous system development 0.06951 Informative Inherited
Biological Process (BP) embryo development 0.3145 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.6547 Informative Inherited
Biological Process (BP) regulation of growth 1 Informative Inherited
Biological Process (BP) system process 0.3636 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 0.9902 Informative Inherited
Biological Process (BP) tissue development 0.2669 Informative Inherited
Biological Process (BP) post-embryonic development 0.01926 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 0.05129 Informative Inherited
Biological Process (BP) circulatory system development 0.4369 Informative Inherited
Biological Process (BP) regulation of GTPase activity 0 Highly Informative Direct
Biological Process (BP) small GTPase mediated signal transduction 0 Highly Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0.0000000000005055 Highly Informative Direct
Biological Process (BP) regulation of cyclic nucleotide metabolic process 0.00000000000119 Highly Informative Direct
Biological Process (BP) phosphatidylinositol metabolic process 0.000000000003365 Highly Informative Direct
Biological Process (BP) regulation of protein import into nucleus 0.00000000006744 Highly Informative Direct
Biological Process (BP) cell division 0.0000000001556 Highly Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0.0000000001732 Highly Informative Direct
Biological Process (BP) chemotaxis 0.0000000007624 Highly Informative Direct
Biological Process (BP) positive regulation of nucleotide metabolic process 0.000000003073 Highly Informative Direct
Biological Process (BP) appendage development 0.000000005729 Highly Informative Direct
Biological Process (BP) negative regulation of locomotion 0.000000008754 Highly Informative Direct
Biological Process (BP) tube morphogenesis 0.00000001307 Highly Informative Direct
Biological Process (BP) negative regulation of cellular component movement 0.00000001402 Highly Informative Direct
Biological Process (BP) lipid modification 0.00000001774 Highly Informative Direct
Biological Process (BP) post-embryonic animal morphogenesis 0.0000001443 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 0.000002459 Highly Informative Direct
Biological Process (BP) regulation of cell shape 0.000006286 Highly Informative Direct
Biological Process (BP) regulation of neuron apoptotic process 0.00003058 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.00004556 Highly Informative Direct
Biological Process (BP) regulation of fibroblast proliferation 0.00006167 Highly Informative Direct
Biological Process (BP) cell growth 0.00007682 Highly Informative Direct
Biological Process (BP) response to peptide hormone 0.0001125 Highly Informative Direct
Biological Process (BP) gliogenesis 0.0002517 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 0.0003093 Highly Informative Direct
Biological Process (BP) morphogenesis of an epithelium 0.0007093 Highly Informative Direct
Biological Process (BP) single-organism behavior 0.0008377 Highly Informative Direct
Biological Process (BP) regulation of neuron projection development 0.004187 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.008884 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 1 Highly Informative Inherited
Biological Process (BP) renal system process 0.03467 Highly Informative Inherited
Biological Process (BP) epithelial cell differentiation 0.641 Highly Informative Inherited
Biological Process (BP) kidney development 0.04871 Highly Informative Inherited
Biological Process (BP) cellular response to organonitrogen compound 0.006465 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 0.1509 Highly Informative Inherited
Biological Process (BP) negative regulation of protein modification process 0.03941 Highly Informative Inherited
Biological Process (BP) negative regulation of phosphate metabolic process 0.4056 Highly Informative Inherited
Biological Process (BP) cell proliferation 0.207 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular signal transduction 0.00204 Highly Informative Inherited
Biological Process (BP) neurological system process 0.1039 Highly Informative Inherited
Biological Process (BP) regulation of protein stability 0.1462 Highly Informative Inherited
Biological Process (BP) circadian rhythm 0.01892 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 0.5296 Highly Informative Inherited
Biological Process (BP) regulation of cell size 1 Highly Informative Inherited
Biological Process (BP) positive regulation of protein transport 1 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular protein localization 0.008619 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.9569 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.3465 Highly Informative Inherited
Biological Process (BP) regulation of cell division 0.1161 Highly Informative Inherited
Biological Process (BP) plasma membrane bounded cell projection organization 0.7277 Highly Informative Inherited
Biological Process (BP) brain development 0.00362 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.6599 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.003039 Highly Informative Inherited
Biological Process (BP) neuron development 0.001168 Highly Informative Inherited
Biological Process (BP) gastrulation 0.4066 Highly Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.9976 Highly Informative Inherited
Molecular Function (MF) binding 0.0001214 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) molecular function regulator 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.000000426 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 0.9609 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 1 Moderately Informative Inherited
Molecular Function (MF) enzyme activator activity 0 Informative Direct
Molecular Function (MF) phospholipid binding 0.000000000000007901 Informative Direct
Molecular Function (MF) enzyme binding 0.000000000002536 Informative Direct
Molecular Function (MF) signal transducer activity 0.0003766 Informative Direct
Molecular Function (MF) molecular transducer activity 0.0006345 Informative Direct
Molecular Function (MF) phosphatase activity 0.03056 Informative Inherited
Molecular Function (MF) receptor binding 0.2813 Informative Inherited
Molecular Function (MF) macromolecular complex binding 0.07387 Informative Inherited
Molecular Function (MF) GTPase regulator activity 0 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0.0002532 Highly Informative Direct
Molecular Function (MF) kinase binding 1 Highly Informative Inherited
Molecular Function (MF) transmembrane signaling receptor activity 0.3259 Highly Informative Inherited
Molecular Function (MF) small GTPase binding 0.1642 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 0.000000502 Least Informative Direct
Cellular Component (CC) membrane 0.004674 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.1197 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) macromolecular complex 1 Least Informative Inherited
Cellular Component (CC) cell projection 0.0000000000023 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.00000000005946 Moderately Informative Direct
Cellular Component (CC) transferase complex 1 Moderately Informative Inherited
Cellular Component (CC) cytoplasmic region 0 Informative Direct
Cellular Component (CC) actin cytoskeleton 0.00000008219 Informative Direct
Cellular Component (CC) extrinsic component of membrane 0.00008245 Informative Direct
Cellular Component (CC) synapse 0.0004503 Informative Direct
Cellular Component (CC) transferase complex, transferring phosphorus-containing groups 0.1477 Informative Inherited
Cellular Component (CC) plasma membrane bounded cell projection part 0.2655 Informative Inherited
Cellular Component (CC) neuron projection 0.5473 Informative Inherited
Cellular Component (CC) cell division site part 0.0000000001927 Highly Informative Direct
Cellular Component (CC) growth cone 0.00001731 Highly Informative Direct
Cellular Component (CC) ruffle 0.0001399 Highly Informative Direct
Cellular Component (CC) cell-cell junction 1 Highly Informative Inherited
Cellular Component (CC) cortical actin cytoskeleton 0.1329 Highly Informative Inherited
Cellular Component (CC) receptor complex 0.03263 Highly Informative Inherited

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)hematopoietic system disease0.3458Moderately InformativeInherited
Disease Ontology (DO)bone marrow disease0.0005527Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of limbs0.004885Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.01754Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the immune system0.04061Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.06101Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the face0.1182Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.1818Least InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.0002625Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the hand0.0005703Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the orbital region0.004332Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.01615Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ear0.04664Moderately InformativeInherited
Phenotypic Abnormality (PA)Behavioral abnormality0.3477Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digit0.7912Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the outer ear0.0003709InformativeDirect
Phenotypic Abnormality (PA)Short digit0.04048InformativeInherited
Phenotypic Abnormality (PA)Juvenile myelomonocytic leukemia0.00002718Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of globe location0.00003023Highly InformativeDirect
Phenotypic Abnormality (PA)Short attention span0.0005951Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.1001Least InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.02944Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.1371Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cerebral hemisphere morphology0.0009576InformativeDirect
Mammalian Phenotype (MP)abnormal metencephalon morphology0.88InformativeInherited
Mammalian Phenotype (MP)ectopic cerebellar granule cells0.000002063Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell morphology variant0.000103Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.0002218Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.004433Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.1678Least InformativeInherited
Worm Phenotype (WP)protein expression variant0.00007402Moderately InformativeDirect
Worm Phenotype (WP)early embryonic lethal0.0332Moderately InformativeInherited
Worm Phenotype (WP)cell component morphology variant0.3177Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.6181Moderately InformativeInherited
Worm Phenotype (WP)muscle cell physiology variant0.0002556InformativeDirect
Worm Phenotype (WP)cytokinesis variant emb0.001488InformativeInherited
Worm Phenotype (WP)mitochondria morphology variant0.06763InformativeInherited
Worm Phenotype (WP)mitochondria alignment variant0.00001138Highly InformativeDirect
Worm Phenotype (WP)cleavage furrow defective0.00006487Highly InformativeDirect
Worm Phenotype (WP)cytokinesis defective early emb0.004474Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)nervous system0.3748Least InformativeInherited
Zebrafish Anatomy (ZA)cell0.27Moderately InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.8142Moderately InformativeInherited
Zebrafish Anatomy (ZA)electrically signaling cell0.07433InformativeInherited
Zebrafish Anatomy (ZA)electrically responsive cell1InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.002693Least InformativeInherited
Enzyme Commission (EC)Transferring phosphorus-containing groups0.02904Least InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0.000000001355Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.000013Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0.000003601InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation0.00000003387Moderately InformativeDirect
Biological processEndocytosis0InformativeDirect
Biological processNeurogenesis0InformativeDirect
Biological processAngiogenesis0.000000000002124InformativeDirect
Biological processStress response0.0006123InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCytoplasm0.001463Least InformativeInherited
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.00000000000001907Moderately InformativeDirect
Cellular componentCytoskeleton0.00000000001539Moderately InformativeDirect
Cellular componentEndosome0.000000001985Moderately InformativeDirect
Cellular componentGolgi apparatus0.000002224Moderately InformativeDirect
Coding sequence diversityAlternative splicing0.000002611Least InformativeDirect
DiseaseTumor suppressor0.00000001375Moderately InformativeDirect
DomainRepeat0.00000911Least InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
DomainZinc-finger0.0000009248Moderately InformativeDirect
DomainSH2 domain0InformativeDirect
DomainSH3 domain0InformativeDirect
DomainSH3-binding0.00000000000005242InformativeDirect
DomainLIM domain0.00003215Highly InformativeDirect
Molecular functionZinc0.00002395Least InformativeDirect
Post-translational modificationDevelopmental protein0.00000000001993Moderately InformativeDirect
Post-translational modificationReceptor0.00001487Moderately InformativeDirect
Post-translational modificationGTPase activation0InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor0InformativeDirect
Post-translational modificationCalmodulin-binding0.00000003627InformativeDirect
Post-translational modificationActin-binding0.0004786InformativeDirect
Post-translational modificationMyosin0.0000001251Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR008936 SSF48350 Protein matches
Abstract

Proteins containing a RhoGAP (Rho GTPase Activating Protein) domain usually function to catalyze the hydrolysis of GTP that is bound to Rho, Rac and/or Cdc42, inactivating these regulators of the actin cytoskeleton. The 53 known human RhoGAP domain-containing proteins are the largest known group of Rho GTPase regulators and significantly outnumber the 21 Rho GTPases they presumably regulate. This excess of GAP proteins probably indicates complex regulation of the Rho GTPases and is consistent with the existence of almost as many (48) human Dbl domain-containing Rho GEFs that act antagonistically to the RhoGAP proteins by activating the Rho GTPases. Phylogenetic analysis offers evidence for frequent domain duplication and for duplication of the entire genes containing these GAP domains [PubMed12297274].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 6 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a GTPase activation domain, GAP domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 6 hidden Markov models representing the GTPase activation domain, GAP superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]