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GTPase activation domain, GAP superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   GTPase activation domain, GAP [ 48349]
Superfamily:   GTPase activation domain, GAP [ 48350] (2)
Families:   BCR-homology GTPase activation domain (BH-domain) [ 48351] (5)
  p120GAP domain-like [ 48360] (2)


Superfamily statistics
Genomes (507) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 15,434 16,705 10
Proteins 15,281 16,608 10


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Molecular Function (MF)molecular function regulator0.0000000580Moderately InformativeDirect
Molecular Function (MF)enzyme activator activity0.0084520InformativeInherited
Molecular Function (MF)GTPase regulator activity0.000000000000039280Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.00000000000001243 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.000000000000192 Least Informative Direct
Biological Process (BP) response to stimulus 0.00000000006852 Least Informative Direct
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) system development 0.0005189 Moderately Informative Direct
Biological Process (BP) cell communication 0 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 0 Moderately Informative Direct
Biological Process (BP) signaling 0 Moderately Informative Direct
Biological Process (BP) regulation of signaling 0.000000000000001902 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.000000000000009009 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 0.000000000001229 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.000000000007235 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.0005183 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 0.002207 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.5211 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) response to stress 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.07101 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.05596 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.3142 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.9216 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of transport 0 Informative Direct
Biological Process (BP) actin filament-based process 0 Informative Direct
Biological Process (BP) regulation of intracellular signal transduction 0 Informative Direct
Biological Process (BP) locomotion 0.000000000000007239 Informative Direct
Biological Process (BP) intracellular signal transduction 0.000000000000116 Informative Direct
Biological Process (BP) regulation of hydrolase activity 0.000000000004287 Informative Direct
Biological Process (BP) cytoskeleton organization 0.00000000000468 Informative Direct
Biological Process (BP) positive regulation of catalytic activity 0.00000000006259 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0.00000000009315 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0.000000001451 Informative Direct
Biological Process (BP) regulation of nervous system development 0.000000001759 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.00000001905 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.00000009292 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.0000001265 Informative Direct
Biological Process (BP) glycerolipid metabolic process 0.0000002042 Informative Direct
Biological Process (BP) regulation of locomotion 0.000001296 Informative Direct
Biological Process (BP) phospholipid metabolic process 0.000003027 Informative Direct
Biological Process (BP) epithelium development 0.000003559 Informative Direct
Biological Process (BP) mitotic cell cycle 0.00007587 Informative Direct
Biological Process (BP) cell cycle process 0.0002836 Informative Direct
Biological Process (BP) regulation of apoptotic process 0.0004338 Informative Direct
Biological Process (BP) behavior 0.0007734 Informative Direct
Biological Process (BP) regulation of protein modification process 0.0007807 Informative Direct
Biological Process (BP) animal organ morphogenesis 0.0008061 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.0009723 Informative Direct
Biological Process (BP) generation of neurons 0.1456 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 1 Informative Inherited
Biological Process (BP) regulation of protein localization 1 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) cell development 0.0172 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 0.9425 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.02422 Informative Inherited
Biological Process (BP) response to nitrogen compound 0.4474 Informative Inherited
Biological Process (BP) cellular response to hormone stimulus 0.01147 Informative Inherited
Biological Process (BP) negative regulation of cellular protein metabolic process 0.03124 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.3926 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.008773 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.0191 Informative Inherited
Biological Process (BP) system process 0.1034 Informative Inherited
Biological Process (BP) growth 0.006601 Informative Inherited
Biological Process (BP) post-embryonic development 0.0142 Informative Inherited
Biological Process (BP) regulation of cell proliferation 1 Informative Inherited
Biological Process (BP) regulation of cellular localization 1 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.6295 Informative Inherited
Biological Process (BP) regulation of cell differentiation 0.6717 Informative Inherited
Biological Process (BP) regulation of phosphorylation 1 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.09491 Informative Inherited
Biological Process (BP) regulation of transferase activity 1 Informative Inherited
Biological Process (BP) negative regulation of cell death 0.5704 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.9191 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) negative regulation of molecular function 1 Informative Inherited
Biological Process (BP) positive regulation of gene expression 0.8081 Informative Inherited
Biological Process (BP) regulation of cell cycle 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.09933 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.001217 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0.03155 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.02564 Informative Inherited
Biological Process (BP) phosphorylation 0.02796 Informative Inherited
Biological Process (BP) central nervous system development 0.03137 Informative Inherited
Biological Process (BP) embryo development 0.6406 Informative Inherited
Biological Process (BP) regulation of growth 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.5995 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 0.03155 Informative Inherited
Biological Process (BP) circulatory system development 0.3094 Informative Inherited
Biological Process (BP) positive regulation of GTPase activity 0 Highly Informative Direct
Biological Process (BP) instar larval or pupal morphogenesis 0 Highly Informative Direct
Biological Process (BP) small GTPase mediated signal transduction 0 Highly Informative Direct
Biological Process (BP) regulation of cyclic nucleotide metabolic process 0.0000000000003081 Highly Informative Direct
Biological Process (BP) phosphatidylinositol metabolic process 0.000000000001603 Highly Informative Direct
Biological Process (BP) regulation of protein import into nucleus 0.00000000005488 Highly Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0.00000000006063 Highly Informative Direct
Biological Process (BP) positive regulation of nucleotide metabolic process 0.000000001276 Highly Informative Direct
Biological Process (BP) cell projection organization 0.000000001488 Highly Informative Direct
Biological Process (BP) chemotaxis 0.000000001687 Highly Informative Direct
Biological Process (BP) metamorphosis 0.000000002286 Highly Informative Direct
Biological Process (BP) negative regulation of cellular component movement 0.000000005184 Highly Informative Direct
Biological Process (BP) negative regulation of locomotion 0.000000007025 Highly Informative Direct
Biological Process (BP) tube morphogenesis 0.00000001561 Highly Informative Direct
Biological Process (BP) appendage development 0.00000001588 Highly Informative Direct
Biological Process (BP) lipid modification 0.00000001635 Highly Informative Direct
Biological Process (BP) cell division 0.00000003767 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 0.000001714 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.00002432 Highly Informative Direct
Biological Process (BP) gliogenesis 0.00003401 Highly Informative Direct
Biological Process (BP) regulation of cell shape 0.00005364 Highly Informative Direct
Biological Process (BP) regulation of fibroblast proliferation 0.00006001 Highly Informative Direct
Biological Process (BP) response to peptide hormone 0.00009401 Highly Informative Direct
Biological Process (BP) cell growth 0.00009537 Highly Informative Direct
Biological Process (BP) neuron development 0.0001755 Highly Informative Direct
Biological Process (BP) regulation of neuron apoptotic process 0.0001776 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 0.0004622 Highly Informative Direct
Biological Process (BP) single-organism behavior 0.0005901 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.00811 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.01494 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 1 Highly Informative Inherited
Biological Process (BP) renal system process 0.04177 Highly Informative Inherited
Biological Process (BP) epithelial cell differentiation 1 Highly Informative Inherited
Biological Process (BP) cellular response to organonitrogen compound 0.004033 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 0.2782 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular signal transduction 0.005216 Highly Informative Inherited
Biological Process (BP) negative regulation of protein modification process 0.04312 Highly Informative Inherited
Biological Process (BP) negative regulation of phosphate metabolic process 0.457 Highly Informative Inherited
Biological Process (BP) cell proliferation 0.1924 Highly Informative Inherited
Biological Process (BP) regulation of protein stability 0.1127 Highly Informative Inherited
Biological Process (BP) circadian rhythm 0.01789 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 0.51 Highly Informative Inherited
Biological Process (BP) regulation of cell size 1 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.3505 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular protein localization 0.005797 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.8527 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.3666 Highly Informative Inherited
Biological Process (BP) regulation of cell division 0.102 Highly Informative Inherited
Biological Process (BP) negative regulation of cytoskeleton organization 0.8232 Highly Informative Inherited
Biological Process (BP) brain development 0.002722 Highly Informative Inherited
Biological Process (BP) cell migration 0.246 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.02333 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.4941 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.001853 Highly Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.7523 Highly Informative Inherited
Molecular Function (MF) binding 0.00005973 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) molecular function regulator 0 Moderately Informative Direct
Molecular Function (MF) protein binding 0.00000000000007073 Moderately Informative Direct
Molecular Function (MF) anion binding 0.0000001384 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 0.9505 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 1 Moderately Informative Inherited
Molecular Function (MF) enzyme activator activity 0 Informative Direct
Molecular Function (MF) phospholipid binding 0.00000000000001324 Informative Direct
Molecular Function (MF) enzyme binding 0.00000000001385 Informative Direct
Molecular Function (MF) signal transducer activity 0.000629 Informative Direct
Molecular Function (MF) receptor binding 0.2726 Informative Inherited
Molecular Function (MF) kinase activity 1 Informative Inherited
Molecular Function (MF) phosphoric ester hydrolase activity 0.1401 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 1 Informative Inherited
Molecular Function (MF) macromolecular complex binding 0.6186 Informative Inherited
Molecular Function (MF) molecular transducer activity 0.001346 Informative Inherited
Molecular Function (MF) GTPase regulator activity 0 Highly Informative Direct
Molecular Function (MF) kinase binding 1 Highly Informative Inherited
Molecular Function (MF) transmembrane signaling receptor activity 0.2764 Highly Informative Inherited
Molecular Function (MF) small GTPase binding 0.2772 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 0.00002172 Least Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0.2536 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) membrane 0.01698 Least Informative Inherited
Cellular Component (CC) cell projection 0.000000000005337 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.000000002675 Moderately Informative Direct
Cellular Component (CC) transferase complex 0.9432 Moderately Informative Inherited
Cellular Component (CC) site of polarized growth 0 Informative Direct
Cellular Component (CC) cytoplasmic region 0 Informative Direct
Cellular Component (CC) cell projection part 0.0000000003231 Informative Direct
Cellular Component (CC) actin cytoskeleton 0.00000009105 Informative Direct
Cellular Component (CC) cell junction 0.0000006579 Informative Direct
Cellular Component (CC) extrinsic component of membrane 0.00001439 Informative Direct
Cellular Component (CC) synapse 0.002127 Informative Inherited
Cellular Component (CC) side of membrane 0.2417 Informative Inherited
Cellular Component (CC) neuron projection 0.1864 Informative Inherited
Cellular Component (CC) cell division site 0.00000000008409 Highly Informative Direct
Cellular Component (CC) growth cone 0.000006792 Highly Informative Direct
Cellular Component (CC) ruffle 0.00007692 Highly Informative Direct
Cellular Component (CC) cell-cell junction 1 Highly Informative Inherited
Cellular Component (CC) anchoring junction 0.5902 Highly Informative Inherited
Cellular Component (CC) receptor complex 0.02997 Highly Informative Inherited

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.4824Least InformativeInherited
Disease Ontology (DO)bone marrow disease0.1874Moderately InformativeInherited
Disease Ontology (DO)polycythemia0.0005694Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of limbs0.008446Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.02556Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the immune system0.06301Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.08161Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the face0.1541Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.2571Least InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.00009842Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the orbital region0.008012Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.008759Moderately InformativeInherited
Phenotypic Abnormality (PA)Behavioral abnormality0.4307Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.5769Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digit0.8191Moderately InformativeInherited
Phenotypic Abnormality (PA)Short digit0.06928InformativeInherited
Phenotypic Abnormality (PA)Juvenile myelomonocytic leukemia0.00002119Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of globe location0.00009842Highly InformativeDirect
Phenotypic Abnormality (PA)Attention deficit hyperactivity disorder0.0002956Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.09569Least InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.0397Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.1636Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal metencephalon morphology0.9081InformativeInherited
Mammalian Phenotype (MP)ectopic cerebellar granule cells0.00003563Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.05608Least InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.03464Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.3378Moderately InformativeInherited
Worm Phenotype (WP)cytokinesis variant emb0.001935InformativeInherited
Worm Phenotype (WP)cytokinesis defective early emb0.004422Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)nervous system0.6467Least InformativeInherited
Zebrafish Anatomy (ZA)cell0.4808Moderately InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.9706Moderately InformativeInherited
Zebrafish Anatomy (ZA)electrically signaling cell0.1224InformativeInherited
Zebrafish Anatomy (ZA)electrically responsive cell1InformativeInherited
Zebrafish Anatomy (ZA)CaP motoneuron0.0001837Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.002771Least InformativeInherited
Enzyme Commission (EC)Transferring phosphorus-containing groups0.02986Least InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0.000000001401Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.0000131Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0.00000358InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation0.00000002446Moderately InformativeDirect
Biological processEndocytosis0InformativeDirect
Biological processNeurogenesis0InformativeDirect
Biological processAngiogenesis0.000000000001923InformativeDirect
Biological processStress response0.0005484InformativeDirect
Cellular componentMembrane0.00000000000001146Least InformativeDirect
Cellular componentCytoplasm0.006311Least InformativeInherited
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.000000000000007359Moderately InformativeDirect
Cellular componentCytoskeleton0.000000000004695Moderately InformativeDirect
Cellular componentEndosome0.000000001141Moderately InformativeDirect
Cellular componentGolgi apparatus0.000001612Moderately InformativeDirect
Coding sequence diversityAlternative splicing0.000002455Least InformativeDirect
DiseaseTumor suppressor0.00000001709Moderately InformativeDirect
DomainRepeat0.000007832Least InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
DomainZinc-finger0.0000008448Moderately InformativeDirect
DomainSH2 domain0InformativeDirect
DomainSH3 domain0InformativeDirect
DomainSH3-binding0.00000000000005266InformativeDirect
DomainLIM domain0.00003233Highly InformativeDirect
Molecular functionZinc0.00002092Least InformativeDirect
Molecular functionCalmodulin-binding0.00000000909InformativeDirect
Molecular functionActin-binding0.0002212InformativeDirect
Post-translational modificationDevelopmental protein0.00000000002918Moderately InformativeDirect
Post-translational modificationReceptor0.00002189Moderately InformativeDirect
Post-translational modificationGTPase activation0InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor0InformativeDirect
Post-translational modificationMyosin0.000000127Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR008936 SSF48350 Protein matches
Abstract

Proteins containing a RhoGAP (Rho GTPase Activating Protein) domain usually function to catalyze the hydrolysis of GTP that is bound to Rho, Rac and/or Cdc42, inactivating these regulators of the actin cytoskeleton. The 53 known human RhoGAP domain-containing proteins are the largest known group of Rho GTPase regulators and significantly outnumber the 21 Rho GTPases they presumably regulate. This excess of GAP proteins probably indicates complex regulation of the Rho GTPases and is consistent with the existence of almost as many (48) human Dbl domain-containing Rho GEFs that act antagonistically to the RhoGAP proteins by activating the Rho GTPases. Phylogenetic analysis offers evidence for frequent domain duplication and for duplication of the entire genes containing these GAP domains [PubMed12297274].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 6 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a GTPase activation domain, GAP domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 6 hidden Markov models representing the GTPase activation domain, GAP superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]