SUPERFAMILY 1.75 HMM library and genome assignments server

GTPase activation domain, GAP superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   GTPase activation domain, GAP [ 48349]
Superfamily:   GTPase activation domain, GAP [ 48350] (2)
Families:   BCR-homology GTPase activation domain (BH-domain) [ 48351] (5)
  p120GAP domain-like [ 48360] (2)


Superfamily statistics
Genomes (506) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 15,408 16,705 10
Proteins 15,253 16,608 10


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process0.00029940.0000000004323Least InformativeDirect
Biological Process (BP)positive regulation of biological process0.2240.00000174Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.28570.0009878Least InformativeInherited
Biological Process (BP)single-organism cellular process0.082140Least InformativeInherited
Biological Process (BP)positive regulation of molecular function0.000010640Moderately InformativeDirect
Biological Process (BP)regulation of phosphorus metabolic process0.000024970Moderately InformativeDirect
Biological Process (BP)regulation of catalytic activity0.000057430Moderately InformativeDirect
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.00015870.00000002098Moderately InformativeDirect
Biological Process (BP)positive regulation of metabolic process0.00020040Moderately InformativeDirect
Biological Process (BP)regulation of signal transduction0.05570Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.1410.000000005609Moderately InformativeInherited
Biological Process (BP)regulation of nucleoside metabolic process0.000000034920InformativeDirect
Biological Process (BP)positive regulation of catabolic process0.000000052330InformativeDirect
Biological Process (BP)regulation of purine nucleotide metabolic process0.00000012040InformativeDirect
Biological Process (BP)positive regulation of hydrolase activity0.00000016120InformativeDirect
Biological Process (BP)regulation of cellular catabolic process0.00000079440InformativeDirect
Biological Process (BP)positive regulation of phosphate metabolic process0.000004240.000000003377InformativeDirect
Biological Process (BP)locomotion0.000065990InformativeDirect
Biological Process (BP)cellular component movement0.00034060.0000000000001622InformativeDirect
Biological Process (BP)regulation of Rho protein signal transduction0.000000000029350.00000000003614Highly InformativeDirect
Biological Process (BP)regulation of Ras GTPase activity0.00000000021320.000000001155Highly InformativeDirect
Biological Process (BP)positive regulation of GTPase activity0.0000000044950Highly InformativeDirect
Molecular Function (MF)enzyme regulator activity0.0000026620Moderately InformativeDirect
Molecular Function (MF)enzyme activator activity0.025390InformativeInherited
Molecular Function (MF)small GTPase regulator activity0.0000000000054070.0000000001165Highly InformativeDirect
Molecular Function (MF)GTPase activator activity0.0046260Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 0.0000000004323 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.0000000000000883 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) positive regulation of biological process 0.00000174 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.0009878 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) localization 0.003359 Least Informative Inherited
Biological Process (BP) positive regulation of molecular function 0 Moderately Informative Direct
Biological Process (BP) regulation of phosphorus metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.00000002098 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0 Moderately Informative Direct
Biological Process (BP) signal transduction 0 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.000000005609 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.00000000000007575 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.000000006761 Moderately Informative Direct
Biological Process (BP) nervous system development 0.00002322 Moderately Informative Direct
Biological Process (BP) single-organism organelle organization 0.000112 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.0003399 Moderately Informative Direct
Biological Process (BP) cell differentiation 0.8685 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) immune system process 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.7718 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.0684 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.591 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.5986 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.3516 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.1815 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleoside metabolic process 0 Informative Direct
Biological Process (BP) positive regulation of catabolic process 0 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0 Informative Direct
Biological Process (BP) positive regulation of phosphate metabolic process 0.000000003377 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) cellular component movement 0.0000000000001622 Informative Direct
Biological Process (BP) cytoskeleton organization 0 Informative Direct
Biological Process (BP) intracellular signal transduction 0 Informative Direct
Biological Process (BP) actin filament-based process 0 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.00000000000004871 Informative Direct
Biological Process (BP) cell projection organization 0.000000000002652 Informative Direct
Biological Process (BP) regulation of locomotion 0.000000000005456 Informative Direct
Biological Process (BP) regulation of cell development 0.00000000007671 Informative Direct
Biological Process (BP) regulation of nervous system development 0.0000000005116 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0.00000000118 Informative Direct
Biological Process (BP) glycerolipid metabolic process 0.000000002189 Informative Direct
Biological Process (BP) localization of cell 0.000000006976 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.00000007183 Informative Direct
Biological Process (BP) phospholipid metabolic process 0.0000001113 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.0000002809 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0.000002349 Informative Direct
Biological Process (BP) epithelium development 0.00007107 Informative Direct
Biological Process (BP) regulation of response to external stimulus 1 Informative Inherited
Biological Process (BP) generation of neurons 0.08985 Informative Inherited
Biological Process (BP) regulation of cell activation 1 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.001496 Informative Inherited
Biological Process (BP) negative regulation of transport 0.02553 Informative Inherited
Biological Process (BP) organelle assembly 0.8367 Informative Inherited
Biological Process (BP) cell division 0.01213 Informative Inherited
Biological Process (BP) organelle fission 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.4537 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.6983 Informative Inherited
Biological Process (BP) regulation of MAPK cascade 1 Informative Inherited
Biological Process (BP) cell proliferation 0.3537 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.2637 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.1959 Informative Inherited
Biological Process (BP) microtubule-based process 0.2784 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.4521 Informative Inherited
Biological Process (BP) neurological system process 0.194 Informative Inherited
Biological Process (BP) synaptic transmission 1 Informative Inherited
Biological Process (BP) regulation of growth 0.8414 Informative Inherited
Biological Process (BP) regulation of cell proliferation 1 Informative Inherited
Biological Process (BP) dephosphorylation 0.06181 Informative Inherited
Biological Process (BP) phosphorylation 0.451 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.9952 Informative Inherited
Biological Process (BP) regulation of secretion 1 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.6738 Informative Inherited
Biological Process (BP) regulation of transferase activity 1 Informative Inherited
Biological Process (BP) negative regulation of cell death 1 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.004214 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.1318 Informative Inherited
Biological Process (BP) regulation of vesicle-mediated transport 0.2764 Informative Inherited
Biological Process (BP) regulation of protein localization 0.7502 Informative Inherited
Biological Process (BP) growth 0.01927 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) response to organonitrogen compound 0.06782 Informative Inherited
Biological Process (BP) cellular response to hormone stimulus 0.2185 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.2335 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.6488 Informative Inherited
Biological Process (BP) cell cycle process 0.1143 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.5584 Informative Inherited
Biological Process (BP) tube development 0.08861 Informative Inherited
Biological Process (BP) central nervous system development 0.01825 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.1484 Informative Inherited
Biological Process (BP) single-organism behavior 0.1338 Informative Inherited
Biological Process (BP) organ morphogenesis 0.001184 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.124 Informative Inherited
Biological Process (BP) biological adhesion 0.001437 Informative Inherited
Biological Process (BP) regulation of immune effector process 0.212 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.07859 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.1772 Informative Inherited
Biological Process (BP) cardiovascular system development 0.4033 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.07175 Informative Inherited
Biological Process (BP) regulation of Rho protein signal transduction 0.00000000003614 Highly Informative Direct
Biological Process (BP) regulation of Ras GTPase activity 0.000000001155 Highly Informative Direct
Biological Process (BP) positive regulation of GTPase activity 0 Highly Informative Direct
Biological Process (BP) small GTPase mediated signal transduction 0 Highly Informative Direct
Biological Process (BP) chemotaxis 0.000000000000003707 Highly Informative Direct
Biological Process (BP) phosphatidylinositol metabolic process 0.000000000000005526 Highly Informative Direct
Biological Process (BP) negative regulation of locomotion 0.0000000000002936 Highly Informative Direct
Biological Process (BP) negative regulation of cellular component movement 0.0000000000002936 Highly Informative Direct
Biological Process (BP) cytokinesis 0.000000001012 Highly Informative Direct
Biological Process (BP) lipid modification 0.00000002106 Highly Informative Direct
Biological Process (BP) cell projection morphogenesis 0.000000034 Highly Informative Direct
Biological Process (BP) regulation of myeloid leukocyte mediated immunity 0.000002134 Highly Informative Direct
Biological Process (BP) post-embryonic organ development 0.00001711 Highly Informative Direct
Biological Process (BP) cell junction organization 0.00001768 Highly Informative Direct
Biological Process (BP) neural tube development 0.00003879 Highly Informative Direct
Biological Process (BP) regulation of neuron apoptotic process 0.00004578 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.0001073 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 0.0002232 Highly Informative Direct
Biological Process (BP) negative regulation of neuron death 0.0002682 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.0003461 Highly Informative Direct
Biological Process (BP) neural precursor cell proliferation 0.0006767 Highly Informative Direct
Biological Process (BP) telencephalon development 0.0007673 Highly Informative Direct
Biological Process (BP) cell adhesion 0.000934 Highly Informative Direct
Biological Process (BP) regulation of chemotaxis 0.06522 Highly Informative Inherited
Biological Process (BP) negative regulation of leukocyte activation 0.02884 Highly Informative Inherited
Biological Process (BP) neuron projection development 0.001039 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular transport 0.02882 Highly Informative Inherited
Biological Process (BP) nuclear division 1 Highly Informative Inherited
Biological Process (BP) epithelial cell development 0.8026 Highly Informative Inherited
Biological Process (BP) kidney development 0.1392 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular signal transduction 0.6767 Highly Informative Inherited
Biological Process (BP) negative regulation of nervous system development 0.001045 Highly Informative Inherited
Biological Process (BP) spindle organization 0.09063 Highly Informative Inherited
Biological Process (BP) neuromuscular process 0.08272 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.02777 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.02732 Highly Informative Inherited
Biological Process (BP) circadian rhythm 0.02743 Highly Informative Inherited
Biological Process (BP) leukocyte migration 0.00514 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 0.6227 Highly Informative Inherited
Biological Process (BP) regulation of nucleocytoplasmic transport 0.01428 Highly Informative Inherited
Biological Process (BP) negative regulation of secretion by cell 0.05839 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.3578 Highly Informative Inherited
Biological Process (BP) negative regulation of immune response 0.378 Highly Informative Inherited
Biological Process (BP) regulation of exocytosis 0.02438 Highly Informative Inherited
Biological Process (BP) negative regulation of protein transport 0.6246 Highly Informative Inherited
Biological Process (BP) regulation of protein targeting 0.009893 Highly Informative Inherited
Biological Process (BP) regulation of protein localization to nucleus 0.2102 Highly Informative Inherited
Biological Process (BP) cell growth 0.001603 Highly Informative Inherited
Biological Process (BP) developmental growth 0.3908 Highly Informative Inherited
Biological Process (BP) regulation of multicellular organism growth 0.107 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.8779 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.07795 Highly Informative Inherited
Biological Process (BP) cellular response to peptide 0.001799 Highly Informative Inherited
Biological Process (BP) response to peptide hormone 0.01013 Highly Informative Inherited
Biological Process (BP) regulation of actin cytoskeleton organization 0.4078 Highly Informative Inherited
Biological Process (BP) regulation of protein complex assembly 0.1078 Highly Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 0.02137 Highly Informative Inherited
Biological Process (BP) cell recognition 0.004865 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 0.002212 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.002267 Highly Informative Inherited
Biological Process (BP) learning or memory 0.001765 Highly Informative Inherited
Biological Process (BP) negative regulation of immune effector process 0.02755 Highly Informative Inherited
Biological Process (BP) epithelial tube formation 0.003236 Highly Informative Inherited
Molecular Function (MF) binding 0.000009982 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) enzyme regulator activity 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.00001918 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 0.9382 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) enzyme activator activity 0 Informative Direct
Molecular Function (MF) enzyme binding 0.0000000002027 Informative Direct
Molecular Function (MF) lipid binding 0.0000012 Informative Direct
Molecular Function (MF) receptor activity 0.000355 Informative Direct
Molecular Function (MF) molecular transducer activity 0.0007649 Informative Direct
Molecular Function (MF) phosphatase activity 0.03259 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 1 Informative Inherited
Molecular Function (MF) kinase activity 1 Informative Inherited
Molecular Function (MF) receptor binding 0.4135 Informative Inherited
Molecular Function (MF) protein complex binding 0.2757 Informative Inherited
Molecular Function (MF) nucleoside-triphosphatase activity 0.3506 Informative Inherited
Molecular Function (MF) small GTPase regulator activity 0.0000000001165 Highly Informative Direct
Molecular Function (MF) GTPase activator activity 0 Highly Informative Direct
Molecular Function (MF) Ras GTPase binding 0 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0.000003542 Highly Informative Direct
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0.0009116 Highly Informative Direct
Molecular Function (MF) phosphatidylinositol binding 0.2568 Highly Informative Inherited
Molecular Function (MF) transmembrane signaling receptor activity 0.2432 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 0.000009309 Least Informative Direct
Cellular Component (CC) membrane 0.0005409 Least Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0.01186 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) cytosol 0 Moderately Informative Direct
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.00000000000000457 Moderately Informative Direct
Cellular Component (CC) plasma membrane part 0.07235 Moderately Informative Inherited
Cellular Component (CC) transferase complex 0.7408 Moderately Informative Inherited
Cellular Component (CC) cell leading edge 0 Informative Direct
Cellular Component (CC) cell cortex 0.000000000000003071 Informative Direct
Cellular Component (CC) actin cytoskeleton 0.00000001262 Informative Direct
Cellular Component (CC) cell junction 0.0000001716 Informative Direct
Cellular Component (CC) synapse 0.004353 Informative Inherited
Cellular Component (CC) neuron projection 0.1732 Informative Inherited
Cellular Component (CC) cell division site part 0.000000000154 Highly Informative Direct
Cellular Component (CC) growth cone 0.000002762 Highly Informative Direct
Cellular Component (CC) receptor complex 0.0328 Highly Informative Inherited

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.4777Least InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.4376Moderately InformativeInherited
Disease Ontology (DO)polycythemia0.0004633Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Somatic mutation0.0003228Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.5926Least InformativeInherited
Phenotypic Abnormality (PA)Behavioral abnormality0.3332InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.4127InformativeInherited
Phenotypic Abnormality (PA)Short attention span0.001175Highly InformativeInherited
Phenotypic Abnormality (PA)Hyperactivity0.005225Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.02831Least InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.05797Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.212Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.5659Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.7365Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.7823Moderately InformativeInherited
Mammalian Phenotype (MP)ectopic neuron0.01905InformativeInherited
Mammalian Phenotype (MP)abnormal metencephalon morphology0.8972InformativeInherited
Mammalian Phenotype (MP)ectopic cerebellar granule cells0.00002165Highly InformativeDirect
Mammalian Phenotype (MP)abnormal amacrine cell morphology0.000443Highly InformativeDirect
Mammalian Phenotype (MP)abnormal ear development0.0009377Highly InformativeDirect
Mammalian Phenotype (MP)abnormal glial cell physiology0.036Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.1217Least InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.03338Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.0817InformativeInherited
Worm Phenotype (WP)cleavage furrow defective early emb0.0000701Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.002599Least InformativeInherited
Enzyme Commission (EC)Transferring phosphorous-containing groups0.03125Least InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0.000000001441Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.00001179Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0.000003042InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation0.0000005389Moderately InformativeDirect
Biological processEndocytosis0InformativeDirect
Biological processNeurogenesis0InformativeDirect
Biological processAngiogenesis0.000000000001738InformativeDirect
Cellular componentMembrane0.0000000000004116Least InformativeDirect
Cellular componentCytoplasm0.03947Least InformativeInherited
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle6.436e-16Moderately InformativeDirect
Cellular componentEndosome0.0000000002281Moderately InformativeDirect
Cellular componentCytoskeleton0.0000000005463Moderately InformativeDirect
Cellular componentGolgi apparatus0.0000001778Moderately InformativeDirect
Coding sequence diversityAlternative splicing0.0000009702Least InformativeDirect
DiseaseTumor suppressor0.0000000001039Moderately InformativeDirect
DomainRepeat0.000002599Least InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
DomainZinc-finger0.0000008645Moderately InformativeDirect
DomainSH2 domain0InformativeDirect
DomainSH3 domain0InformativeDirect
DomainSH3-binding0.00000000000006165InformativeDirect
DomainLIM domain0.0000304Highly InformativeDirect
Molecular functionZinc0.00001228Least InformativeDirect
Molecular functionCalmodulin-binding0.000000008406InformativeDirect
Molecular functionActin-binding0.0002082InformativeDirect
Post-translational modificationDevelopmental protein0.00000000001835Moderately InformativeDirect
Post-translational modificationReceptor0.00002088Moderately InformativeDirect
Post-translational modificationGTPase activation0InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor0InformativeDirect
Post-translational modificationMyosin0.0000001274Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR008936 SSF48350 Protein matches
Abstract

Proteins containing a RhoGAP (Rho GTPase Activating Protein) domain usually function to catalyze the hydrolysis of GTP that is bound to Rho, Rac and/or Cdc42, inactivating these regulators of the actin cytoskeleton. The 53 known human RhoGAP domain-containing proteins are the largest known group of Rho GTPase regulators and significantly outnumber the 21 Rho GTPases they presumably regulate. This excess of GAP proteins probably indicates complex regulation of the Rho GTPases and is consistent with the existence of almost as many (48) human Dbl domain-containing Rho GEFs that act antagonistically to the RhoGAP proteins by activating the Rho GTPases. Phylogenetic analysis offers evidence for frequent domain duplication and for duplication of the entire genes containing these GAP domains [PubMed12297274].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 6 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a GTPase activation domain, GAP domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 6 hidden Markov models representing the GTPase activation domain, GAP superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


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