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Ras GEF superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Ras GEF [ 48365]
Superfamily:   Ras GEF [ 48366]
Families:   Ras GEF [ 48367]


Superfamily statistics
Genomes (400) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 5,590 6,034 6
Proteins 5,383 5,895 6


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of metabolic process0.0037870.000000000002646Least InformativeInherited
Biological Process (BP)regulation of cellular process0.0018030Least InformativeInherited
Biological Process (BP)regulation of signal transduction0.0000000022250Moderately InformativeDirect
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.00000015530.00000000003516Moderately InformativeDirect
Biological Process (BP)regulation of catalytic activity0.00036230Moderately InformativeDirect
Biological Process (BP)positive regulation of molecular function0.024430.0000000001088Moderately InformativeInherited
Biological Process (BP)regulation of phosphate metabolic process10Moderately InformativeInherited
Biological Process (BP)regulation of nucleoside metabolic process0.0000000000000016840InformativeDirect
Biological Process (BP)regulation of cellular catabolic process0.00000000000063980InformativeDirect
Biological Process (BP)positive regulation of hydrolase activity0.000000000000073460InformativeDirect
Biological Process (BP)regulation of purine nucleotide metabolic process0.000000000000028910InformativeDirect
Biological Process (BP)positive regulation of Ras GTPase activity0.0001980.0000008109Highly InformativeDirect
Molecular Function (MF)enzyme regulator activity0.000000000051330Moderately InformativeDirect
Molecular Function (MF)GTPase regulator activity00InformativeDirect
Molecular Function (MF)guanyl-nucleotide exchange factor activity00Highly InformativeDirect
Molecular Function (MF)small GTPase regulator activity0.0016480.009967Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of metabolic process 0.000000000002646 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.00004159 Least Informative Direct
Biological Process (BP) developmental process 0.0001023 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.00000000006169 Least Informative Direct
Biological Process (BP) regulation of cellular process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0.000000000003213 Least Informative Direct
Biological Process (BP) localization 0.6953 Least Informative Inherited
Biological Process (BP) signal transduction 0.0000000003511 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.00000000003516 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) cell differentiation 0.0008407 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 0.0000000001088 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.4371 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.08962 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.05773 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.9175 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.03981 Moderately Informative Inherited
Biological Process (BP) organ development 0.5157 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.1556 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.1605 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.5122 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.8684 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.1374 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.7097 Moderately Informative Inherited
Biological Process (BP) immune system process 0.05152 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.000003911 Informative Direct
Biological Process (BP) cellular component movement 0.0007337 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.0000001175 Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 0 Informative Direct
Biological Process (BP) response to wounding 0.0005087 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.0003011 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0 Informative Direct
Biological Process (BP) positive regulation of protein modification process 0.0000002311 Informative Direct
Biological Process (BP) intracellular signal transduction 0.00000000000001945 Informative Direct
Biological Process (BP) locomotion 0.000002831 Informative Direct
Biological Process (BP) generation of neurons 0.000000401 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0 Informative Direct
Biological Process (BP) localization of cell 0.00003168 Informative Direct
Biological Process (BP) regulation of cell development 0.000005887 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0 Informative Direct
Biological Process (BP) cellular response to nitrogen compound 0.0003801 Informative Direct
Biological Process (BP) regulation of nervous system development 0.006128 Informative Inherited
Biological Process (BP) regulation of locomotion 0.3591 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.2215 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.1664 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.422 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 1 Informative Inherited
Biological Process (BP) regulation of cell proliferation 1 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.06714 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.04513 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.6545 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.6898 Informative Inherited
Biological Process (BP) reproductive system development 0.2601 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.008879 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.002049 Informative Inherited
Biological Process (BP) response to organonitrogen compound 0.001916 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.02113 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 1 Informative Inherited
Biological Process (BP) epithelium development 0.03296 Informative Inherited
Biological Process (BP) response to nutrient levels 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) regulation of system process 0.05817 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.02183 Informative Inherited
Biological Process (BP) microtubule-based process 0.4418 Informative Inherited
Biological Process (BP) organelle localization 0.01755 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.03972 Informative Inherited
Biological Process (BP) secretion by cell 0.006072 Informative Inherited
Biological Process (BP) regulation of ion transport 0.07654 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.1273 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) central nervous system development 0.2163 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.1697 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.06018 Informative Inherited
Biological Process (BP) defense response 0.343 Informative Inherited
Biological Process (BP) leukocyte activation 0.2135 Informative Inherited
Biological Process (BP) immune effector process 0.1328 Informative Inherited
Biological Process (BP) immune response 0.7859 Informative Inherited
Biological Process (BP) cardiovascular system development 0.01813 Informative Inherited
Biological Process (BP) MAPK cascade 0.000005054 Highly Informative Direct
Biological Process (BP) epithelial cell development 0.0004059 Highly Informative Direct
Biological Process (BP) myeloid leukocyte activation 0.000005099 Highly Informative Direct
Biological Process (BP) leukocyte activation involved in immune response 0.0000181 Highly Informative Direct
Biological Process (BP) leukocyte mediated immunity 0.0001913 Highly Informative Direct
Biological Process (BP) exocytosis 0.0000006306 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0 Highly Informative Direct
Biological Process (BP) small GTPase mediated signal transduction 0 Highly Informative Direct
Biological Process (BP) hemostasis 0.0003703 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 0.000005491 Highly Informative Direct
Biological Process (BP) response to purine-containing compound 0.0000000002986 Highly Informative Direct
Biological Process (BP) positive regulation of cell migration 0.0002088 Highly Informative Direct
Biological Process (BP) positive regulation of Ras GTPase activity 0.0000008109 Highly Informative Direct
Biological Process (BP) positive regulation of programmed cell death 0.00002563 Highly Informative Direct
Biological Process (BP) regulation of synaptic transmission 0.00000273 Highly Informative Direct
Biological Process (BP) regulation of protein kinase B signaling cascade 0.0005337 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 0.00002154 Highly Informative Direct
Biological Process (BP) regulation of neural precursor cell proliferation 0.000007853 Highly Informative Direct
Biological Process (BP) positive regulation of protein kinase activity 0.04918 Highly Informative Inherited
Biological Process (BP) microtubule-based movement 0.03246 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.06554 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0.001062 Highly Informative Inherited
Biological Process (BP) regulation of Rho GTPase activity 1 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane transport 0.004395 Highly Informative Inherited
Biological Process (BP) regulation of binding 1 Highly Informative Inherited
Biological Process (BP) regulation of transporter activity 0.1369 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.2681 Highly Informative Inherited
Biological Process (BP) wound healing 0.4775 Highly Informative Inherited
Biological Process (BP) coagulation 0.007684 Highly Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 0.1594 Highly Informative Inherited
Biological Process (BP) inflammatory response 0.002128 Highly Informative Inherited
Molecular Function (MF) binding 0.003141 Least Informative Inherited
Molecular Function (MF) enzyme regulator activity 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.08034 Moderately Informative Inherited
Molecular Function (MF) nucleotide binding 0.0004493 Informative Direct
Molecular Function (MF) enzyme binding 0.0000003361 Informative Direct
Molecular Function (MF) GTPase regulator activity 0 Informative Direct
Molecular Function (MF) receptor binding 0.225 Informative Inherited
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0 Highly Informative Direct
Molecular Function (MF) Ras GTPase binding 0 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0.005702 Highly Informative Inherited
Molecular Function (MF) small GTPase regulator activity 0.009967 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 0.1339 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) protein complex 0.817 Least Informative Inherited
Cellular Component (CC) membrane 0.00854 Least Informative Inherited
Cellular Component (CC) cytosol 0.000001693 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.000169 Moderately Informative Direct
Cellular Component (CC) lytic vacuole 0.009883 Informative Inherited
Cellular Component (CC) endosome 0.01469 Informative Inherited
Cellular Component (CC) late endosome 0.0009291 Highly Informative Direct
Cellular Component (CC) cell body 0.000002346 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 0.000174 Highly Informative Direct
Cellular Component (CC) lysosome 0.004503 Highly Informative Inherited

Document: GO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.4209Least InformativeInherited
Mammalian Phenotype (MP)abnormal cell adhesion0.000586Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.0121Least InformativeInherited
Enzyme Commission (EC)Phosphoric diester hydrolases0.000000001206InformativeDirect
Enzyme Commission (EC)Phosphoinositide phospholipase C0.0000000000002102Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation0.00000000000001114Moderately InformativeDirect
Biological processCell cycle0.000009369Moderately InformativeDirect
Biological processNeurogenesis0.00000000936InformativeDirect
Biological processMitosis0.0006971InformativeDirect
Cellular componentMembrane0.00000005098Least InformativeDirect
Cellular componentCell junction0.00000000006324Moderately InformativeDirect
Cellular componentEndosome0.00000000009091Moderately InformativeDirect
Cellular componentGolgi apparatus0.000005995Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0.00002381Moderately InformativeDirect
Cellular componentCell membrane0.0003996Moderately InformativeDirect
Cellular componentSynapse0.6756InformativeInherited
Cellular componentSynaptosome0.000000000004783Highly InformativeDirect
DomainRepeat0.0002524Least InformativeDirect
DomainCoiled coil0.000000001769Moderately InformativeDirect
DomainZinc-finger0.0003947Moderately InformativeDirect
DomainSH2 domain0.0000000000422InformativeDirect
DomainSH3 domain0.00000003485InformativeDirect
Molecular functionNucleotide-binding1Least InformativeInherited
Molecular functionCalcium0.00000000000004299Moderately InformativeDirect
Molecular functioncAMP-binding0.00000000002085Highly InformativeDirect
Molecular functioncAMP0.000000001069Highly InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor0InformativeDirect
Post-translational modificationGTPase activation0.000000000003608InformativeDirect
Post-translational modificationPhosphoprotein0.00000000000002545Least InformativeDirect
Post-translational modificationUbl conjugation0.000007688Moderately InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR008937 SSF48366 Protein matches
Abstract

Small GTPases of the Ras family alternate between 2 conformations induced by the binding of either GTP or GDP. Guanine nucleotide exchange factors (GEFs) induce the dissociation of GDP to allow association of the more abundant GTP. The Ras-like family of small GTPases includes, among others, Ras, Rap1, R-ras, and Ral. The family is characterised by similarities in the effector domain. The Ras GTPase Rap1 is activated rapidly in response to activation of a variety of receptors. Rap1 activation is mediated by several second messengers, including calcium, diacylglycerol, and cAMP. GEFs have been identified that mediate these effects. One such GEF is Epac, an exchange protein directly activated by cAMP, which represents a novel cAMP-induced, protein kinase A-independent pathway [PubMed10579920].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Ras GEF domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Ras GEF superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]