SUPERFAMILY 1.75 HMM library and genome assignments server


Ras GEF superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Ras GEF [ 48365]
Superfamily:   Ras GEF [ 48366]
Families:   Ras GEF [ 48367]


Superfamily statistics
Genomes (365) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 5,131 4,563 6
Proteins 4,935 4,472 6


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Molecular Function (MF)enzyme regulator activity1.165e-120Moderately InformativeDirect
Molecular Function (MF)GTPase regulator activity00InformativeDirect
Molecular Function (MF)guanyl-nucleotide exchange factor activity00Highly InformativeDirect
Molecular Function (MF)small GTPase regulator activity0.001440.06577Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0.0001698 Least Informative Direct
Biological Process (BP) single-organism cellular process 1.664e-08 Least Informative Direct
Biological Process (BP) response to stimulus 6.355e-13 Least Informative Direct
Biological Process (BP) developmental process 0.004693 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.01257 Least Informative Inherited
Biological Process (BP) signal transduction 3.682e-14 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 2.248e-06 Moderately Informative Direct
Biological Process (BP) regulation of signaling 3.781e-07 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 1.095e-05 Moderately Informative Direct
Biological Process (BP) reproduction 0.7081 Moderately Informative Inherited
Biological Process (BP) organ development 0.6383 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.005222 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.9344 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.5386 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.459 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 0.2717 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.5019 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.7671 Moderately Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 6.726e-06 Informative Direct
Biological Process (BP) response to wounding 0.0002625 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 2.258e-14 Informative Direct
Biological Process (BP) intracellular signal transduction 1.862e-08 Informative Direct
Biological Process (BP) positive regulation of catalytic activity 0.0009991 Informative Direct
Biological Process (BP) secretion 0.0003117 Informative Direct
Biological Process (BP) developmental process involved in reproduction 0.8972 Informative Inherited
Biological Process (BP) reproductive system development 0.6271 Informative Inherited
Biological Process (BP) response to external stimulus 0.2592 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.03718 Informative Inherited
Biological Process (BP) regulation of system process 0.004318 Informative Inherited
Biological Process (BP) cellular component movement 0.08506 Informative Inherited
Biological Process (BP) microtubule-based process 0.2739 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.02467 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 0.005655 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.03968 Informative Inherited
Biological Process (BP) defense response 0.4642 Informative Inherited
Biological Process (BP) cell activation 0.00104 Informative Inherited
Biological Process (BP) immune effector process 0.01047 Informative Inherited
Biological Process (BP) immune response 0.7166 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.00427 Informative Inherited
Biological Process (BP) positive regulation of phosphorus metabolic process 0.03773 Informative Inherited
Biological Process (BP) positive regulation of protein metabolic process 0.006122 Informative Inherited
Biological Process (BP) myeloid leukocyte activation 3.191e-06 Highly Informative Direct
Biological Process (BP) leukocyte activation involved in immune response 8.694e-06 Highly Informative Direct
Biological Process (BP) leukocyte mediated immunity 0.0001586 Highly Informative Direct
Biological Process (BP) exocytosis 7.498e-07 Highly Informative Direct
Biological Process (BP) microtubule-based movement 0.0009636 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 5.966e-15 Highly Informative Direct
Biological Process (BP) small GTPase mediated signal transduction 0 Highly Informative Direct
Biological Process (BP) hemostasis 0.0002849 Highly Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 0 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 0.0005317 Highly Informative Direct
Biological Process (BP) regulation of neurological system process 0.004109 Highly Informative Inherited
Biological Process (BP) organelle localization 0.00244 Highly Informative Inherited
Biological Process (BP) regulation of purine nucleotide catabolic process 0.0587 Highly Informative Inherited
Biological Process (BP) regulation of Ras protein signal transduction 0.8501 Highly Informative Inherited
Biological Process (BP) wound healing 0.4458 Highly Informative Inherited
Biological Process (BP) coagulation 0.003334 Highly Informative Inherited
Biological Process (BP) inflammatory response 0.003037 Highly Informative Inherited
Molecular Function (MF) binding 0.2329 Least Informative Inherited
Molecular Function (MF) protein binding 0.0008721 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 0 Moderately Informative Direct
Molecular Function (MF) organic cyclic compound binding 1 Moderately Informative Inherited
Molecular Function (MF) heterocyclic compound binding 1 Moderately Informative Inherited
Molecular Function (MF) enzyme binding 9.637e-07 Informative Direct
Molecular Function (MF) GTPase regulator activity 0 Informative Direct
Molecular Function (MF) nucleotide binding 0.1015 Informative Inherited
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0 Highly Informative Direct
Molecular Function (MF) small GTPase regulator activity 0.06577 Highly Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.5972 Least Informative Inherited
Cellular Component (CC) cytosol 3.185e-07 Moderately Informative Direct
Cellular Component (CC) extracellular region 0.4234 Moderately Informative Inherited
Cellular Component (CC) extracellular matrix 0.0007928 Informative Direct
Cellular Component (CC) proteinaceous extracellular matrix 0.0001204 Highly Informative Direct

Document: GO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.318Least InformativeInherited
Mammalian Phenotype (MP)abnormal cell adhesion0.0007421Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.01251Least InformativeInherited
Enzyme Commission (EC)Phosphoric diester hydrolases1.205e-09InformativeDirect
Enzyme Commission (EC)Phosphoinositide phospholipase C2.182e-13Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation4.875e-09Moderately InformativeDirect
Biological processCell cycle6.989e-06Moderately InformativeDirect
Biological processMitosis0.0005821InformativeDirect
Cellular componentMembrane1.683e-07Least InformativeDirect
Cellular componentGolgi apparatus3.772e-06Moderately InformativeDirect
Cellular componentCell junction1.389e-05Moderately InformativeDirect
Cellular componentEndoplasmic reticulum1.452e-05Moderately InformativeDirect
Cellular componentSynapse4.696e-07InformativeDirect
Cellular componentSynaptosome2.061e-12Highly InformativeDirect
DomainRepeat0.0001651Least InformativeDirect
DomainCoiled coil1.052e-09Moderately InformativeDirect
DomainSH2 domain4.529e-11InformativeDirect
DomainSH3 domain3.637e-08InformativeDirect
Molecular functionMetal-binding1Least InformativeInherited
Molecular functionCalcium2.194e-14Moderately InformativeDirect
Molecular functionZinc-finger1.692e-07Moderately InformativeDirect
Molecular functioncAMP9.829e-10Highly InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor0InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR008937 SSF48366 Protein matches
Abstract

Small GTPases of the Ras family alternate between 2 conformations induced by the binding of either GTP or GDP. Guanine nucleotide exchange factors (GEFs) induce the dissociation of GDP to allow association of the more abundant GTP. The Ras-like family of small GTPases includes, among others, Ras, Rap1, R-ras, and Ral. The family is characterised by similarities in the effector domain. The Ras GTPase Rap1 is activated rapidly in response to activation of a variety of receptors. Rap1 activation is mediated by several second messengers, including calcium, diacylglycerol, and cAMP. GEFs have been identified that mediate these effects. One such GEF is Epac, an exchange protein directly activated by cAMP, which represents a novel cAMP-induced, protein kinase A-independent pathway [PubMed10579920].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Ras GEF domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Ras GEF superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]