SUPERFAMILY 1.75 HMM library and genome assignments server

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ARM repeat superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   alpha-alpha superhelix [ 48370] (24)
Superfamily:   ARM repeat [ 48371] (23)
Families:   Armadillo repeat [ 48372] (6)
  Clathrin adaptor core protein [ 74771] (2)
  HEAT repeat [ 48385] (2)
  MIF4G domain-like [ 100908] (5)
  PHAT domain [ 89129]
  Mo25 protein [ 101407]
  Leukotriene A4 hydrolase C-terminal domain [ 63608]
  Clathrin heavy chain proximal leg segment [ 48390]
  Clathrin heavy-chain linker domain [ 48393]
  Leucine-rich repeat variant [ 48396]
  Phoshoinositide 3-kinase (PI3K) helical domain [ 48399]
  Pumilio repeat [ 63611]
  Regulatory subunit H of the V-type ATPase [ 63614]
  PBS lyase HEAT-like repeat [ 101410] (2)
  BC3264-like [ 109965] (2)
  Eukaryotic translation initiation factor 3 subunit 12, eIF3k, N-terminal domain [ 109968]
  Exportin HEAT-like repeat [ 117002]
  B56-like [ 140819]
  HspBP1 domain [ 140822]
  GUN4-associated domain [ 140825] (2)
  Diap1 N-terninal region-like [ 140830]
  Plakophilin 1 helical region [ 140833]
  RPA1889-like [ 158764]


Superfamily statistics
Genomes (2,503) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 147,501 479,904 107
Proteins 123,570 406,390 92


Functional annotation
General category General
Detailed category General

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0.01346Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases0.05767Least InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Omega peptidases0.0000001704Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0.00001023Moderately InformativeDirect
Enzyme Commission (EC)Acting on ether bonds0InformativeDirect
Enzyme Commission (EC)Miscellaneous (requires further characterization)0InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol 3-kinase0Highly InformativeDirect
Enzyme Commission (EC)Leukotriene-A(4) hydrolase0Highly InformativeDirect
Enzyme Commission (EC)1-phosphatidylinositol 4-kinase0Highly InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-4,5-bisphosphate 3-kinase0Highly InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-4-phosphate 3-kinase0.000000000000004166Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)gastrointestinal system disease0.5135Moderately InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the head0.0001811Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.0005443Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the musculature0.01503Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.6295Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cerebrum0.0006564Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormal muscle tone0.2772Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal skeletal muscle morphology0.82Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal cerebellum morphology0.00002794InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the glial cells0.0006755InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the lower urinary tract0.1949InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the voice0.2967InformativeInherited
Phenotypic Abnormality (PA)Muscular hypotonia0.7794InformativeInherited
Phenotypic Abnormality (PA)Functional abnormality of the bladder0.07886Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging0.007002Least InformativeInherited
Mammalian Phenotype (MP)prenatal lethality0.001415Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.06338Moderately InformativeInherited
Mammalian Phenotype (MP)neoplasm0.2129Moderately InformativeInherited
Mammalian Phenotype (MP)increased urinary system tumor incidence0.00152Highly InformativeInherited
Mammalian Phenotype (MP)increased adenoma incidence0.128Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell morphology variant0Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0Least InformativeDirect
Worm Phenotype (WP)blast cell physiology variant0Least InformativeDirect
Worm Phenotype (WP)cell development variant0.0000000000006502Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.000000000001577Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.0000000007875Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.00000006284Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.1114Least InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.000000000000466Moderately InformativeDirect
Worm Phenotype (WP)protein expression variant0.000000007512Moderately InformativeDirect
Worm Phenotype (WP)developmental morphology variant0.0000000768Moderately InformativeDirect
Worm Phenotype (WP)body morphology variant0.0000001427Moderately InformativeDirect
Worm Phenotype (WP)body region morphology variant0.0000001974Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant0.0000001974Moderately InformativeDirect
Worm Phenotype (WP)adult body morphology variant0.0000002073Moderately InformativeDirect
Worm Phenotype (WP)cell organization biogenesis variant0.01388Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.0171Moderately InformativeInherited
Worm Phenotype (WP)organism stress response variant0.0263Moderately InformativeInherited
Worm Phenotype (WP)reproductive system morphology variant0.03506Moderately InformativeInherited
Worm Phenotype (WP)germ cell morphology variant0.07496Moderately InformativeInherited
Worm Phenotype (WP)apoptosis variant0.1684Moderately InformativeInherited
Worm Phenotype (WP)germ cell development variant0.5852Moderately InformativeInherited
Worm Phenotype (WP)brood size variant0.0000000008457InformativeDirect
Worm Phenotype (WP)embryonic cell organization biogenesis variant0.000000004238InformativeDirect
Worm Phenotype (WP)cytokinesis variant emb0.000005012InformativeDirect
Worm Phenotype (WP)sick0.00001245InformativeDirect
Worm Phenotype (WP)oocyte physiology variant0.00002427InformativeDirect
Worm Phenotype (WP)pigmentation variant0.000045InformativeDirect
Worm Phenotype (WP)vesicle morphology variant0.000118InformativeDirect
Worm Phenotype (WP)germ cell cytoplasmic morphology variant0.02245InformativeInherited
Worm Phenotype (WP)male mating variant0.03098InformativeInherited
Worm Phenotype (WP)non apoptotic cell death variant0.4927InformativeInherited
Worm Phenotype (WP)seam cell morphology variant0.00005343Highly InformativeDirect
Worm Phenotype (WP)embryonic arrest0.00005676Highly InformativeDirect
Worm Phenotype (WP)cell polarity variant0.0001978Highly InformativeDirect
Worm Phenotype (WP)egg morphology variant0.0002268Highly InformativeDirect
Worm Phenotype (WP)RNAi response variant0.0004032Highly InformativeDirect
Worm Phenotype (WP)sex determination variant0.0004419Highly InformativeDirect
Worm Phenotype (WP)nuclear number variant0.0007666Highly InformativeDirect
Worm Phenotype (WP)hatching variant0.0009481Highly InformativeDirect
Worm Phenotype (WP)cell fusion variant0.08347Highly InformativeInherited
Worm Phenotype (WP)lineage variant0.3324Highly InformativeInherited
Worm Phenotype (WP)P granule defective0.3821Highly InformativeInherited
Worm Phenotype (WP)germline proliferation variant0.8312Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)metabolism and growth0.4541Least InformativeInherited
Yeast Phenotype (YP)intracellular transport0.001582InformativeInherited
Yeast Phenotype (YP)protein transport0.0004348Highly InformativeDirect
Yeast Phenotype (YP)protein/peptide distribution0.0006663Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0.0346Least InformativeInherited
Fly Phenotype (FP)lethal0.3644Moderately InformativeInherited

Document: FP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)urogenital system0.000000007507Least InformativeDirect
Xenopus ANatomical entity (XAN)trunk0.0000322Least InformativeDirect
Xenopus ANatomical entity (XAN)cavitated compound organ0.002939Least InformativeInherited
Xenopus ANatomical entity (XAN)nervous system0.005714Least InformativeInherited
Xenopus ANatomical entity (XAN)testis0.000000000000004591Moderately InformativeDirect
Xenopus ANatomical entity (XAN)germ cell0.00961Moderately InformativeInherited
Xenopus ANatomical entity (XAN)anatomical entity in vitro0.000811InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0.00006124Least InformativeDirect
Plant ANatomical entity (PAN)sporangium0.0003798Least InformativeDirect
Plant ANatomical entity (PAN)whole plant0.03804Least InformativeInherited
Plant ANatomical entity (PAN)microsporophyll0.09409Least InformativeInherited
Plant ANatomical entity (PAN)pollen0.0002784Moderately InformativeDirect
Plant ANatomical entity (PAN)bud0.000122Highly InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0.0005929Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0.0009097Least InformativeDirect
Plant structure DEvelopment stage (PDE)pollen development stage0.0002554Moderately InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0.000000000004893Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases0.3866Least InformativeInherited
Enzyme Commission (EC)Hydrolases0.9949Least InformativeInherited
Enzyme Commission (EC)Aminoacyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0.00003651Moderately InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0.01096Moderately InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0.00000000009572InformativeDirect
Enzyme Commission (EC)Omega peptidases0.000002636InformativeDirect
Enzyme Commission (EC)RING-type E3 ubiquitin transferase0.00003188InformativeDirect
Enzyme Commission (EC)Acting on CH or CH(2) groups0.005998InformativeInherited
Enzyme Commission (EC)Miscellaneous0Highly InformativeDirect
Enzyme Commission (EC)Acting on ether bonds0Highly InformativeDirect
Enzyme Commission (EC)HECT-type E3 ubiquitin transferase0.000000014Highly InformativeDirect
Enzyme Commission (EC)Aminopeptidases0.007348Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentPhycobilisome0.000000002785Moderately InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 75 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a ARM repeat domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 75 hidden Markov models representing the ARM repeat superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]