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ARM repeat superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   alpha-alpha superhelix [ 48370] (24)
Superfamily:   ARM repeat [ 48371] (23)
Families:   Armadillo repeat [ 48372] (6)
  Clathrin adaptor core protein [ 74771] (2)
  HEAT repeat [ 48385] (2)
  MIF4G domain-like [ 100908] (5)
  PHAT domain [ 89129]
  Mo25 protein [ 101407]
  Leukotriene A4 hydrolase C-terminal domain [ 63608]
  Clathrin heavy chain proximal leg segment [ 48390]
  Clathrin heavy-chain linker domain [ 48393]
  Leucine-rich repeat variant [ 48396]
  Phoshoinositide 3-kinase (PI3K) helical domain [ 48399]
  Pumilio repeat [ 63611]
  Regulatory subunit H of the V-type ATPase [ 63614]
  PBS lyase HEAT-like repeat [ 101410] (2)
  BC3264-like [ 109965] (2)
  Eukaryotic translation initiation factor 3 subunit 12, eIF3k, N-terminal domain [ 109968]
  Exportin HEAT-like repeat [ 117002]
  B56-like [ 140819]
  HspBP1 domain [ 140822]
  GUN4-associated domain [ 140825] (2)
  Diap1 N-terninal region-like [ 140830]
  Plakophilin 1 helical region [ 140833]
  RPA1889-like [ 158764]


Superfamily statistics
Genomes (2,503) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 147,501 479,904 107
Proteins 123,570 406,390 92


Functional annotation
General category General
Detailed category General

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0.01346Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases0.05767Least InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Omega peptidases0.0000001704Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0.00001023Moderately InformativeDirect
Enzyme Commission (EC)Acting on ether bonds0InformativeDirect
Enzyme Commission (EC)Miscellaneous (requires further characterization)0InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol 3-kinase0Highly InformativeDirect
Enzyme Commission (EC)Leukotriene-A(4) hydrolase0Highly InformativeDirect
Enzyme Commission (EC)1-phosphatidylinositol 4-kinase0Highly InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-4,5-bisphosphate 3-kinase0Highly InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-4-phosphate 3-kinase0.000000000000004166Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)gastrointestinal system disease0.5294Moderately InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Somatic mutation0.0005387InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.0006475Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.4109Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.5859Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cerebrum0.001148Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the glial cells0.0006515InformativeDirect
Phenotypic Abnormality (PA)Behavioral abnormality0.1441InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower urinary tract0.1718InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the voice0.2368Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the bladder0.2562Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging0.006925Least InformativeInherited
Mammalian Phenotype (MP)prenatal lethality0.001443Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.06364Moderately InformativeInherited
Mammalian Phenotype (MP)neoplasm0.2135Moderately InformativeInherited
Mammalian Phenotype (MP)increased urinary system tumor incidence0.001522Highly InformativeInherited
Mammalian Phenotype (MP)increased adenoma incidence0.128Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell morphology variant0Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0Least InformativeDirect
Worm Phenotype (WP)cell development variant0.0000000000001282Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.000000000001226Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.000000000855Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.000001277Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.1199Least InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.0000000000003761Moderately InformativeDirect
Worm Phenotype (WP)protein expression variant0.0000000067Moderately InformativeDirect
Worm Phenotype (WP)cell division variant0.005029Moderately InformativeInherited
Worm Phenotype (WP)germ cell morphology variant0.01758Moderately InformativeInherited
Worm Phenotype (WP)organism stress response variant0.03085Moderately InformativeInherited
Worm Phenotype (WP)reproductive system morphology variant0.05154Moderately InformativeInherited
Worm Phenotype (WP)gametogenesis variant0.09032Moderately InformativeInherited
Worm Phenotype (WP)apoptosis variant0.2101Moderately InformativeInherited
Worm Phenotype (WP)cell component morphology variant0.3443Moderately InformativeInherited
Worm Phenotype (WP)brood size variant0.0000000002344InformativeDirect
Worm Phenotype (WP)embryonic cell organization biogenesis variant0.00000001409InformativeDirect
Worm Phenotype (WP)cytokinesis variant emb0.000001275InformativeDirect
Worm Phenotype (WP)sick0.000017InformativeDirect
Worm Phenotype (WP)pigmentation variant0.00005035InformativeDirect
Worm Phenotype (WP)oocyte physiology variant0.0001375InformativeDirect
Worm Phenotype (WP)germ cell cytoplasmic morphology variant0.1476InformativeInherited
Worm Phenotype (WP)embryonic arrest0.00005346Highly InformativeDirect
Worm Phenotype (WP)developmental morphology variant0.00005456Highly InformativeDirect
Worm Phenotype (WP)seam cell morphology variant0.00008199Highly InformativeDirect
Worm Phenotype (WP)RNAi response variant0.0003593Highly InformativeDirect
Worm Phenotype (WP)sex determination variant0.0004139Highly InformativeDirect
Worm Phenotype (WP)multiple nuclei0.0007007Highly InformativeDirect
Worm Phenotype (WP)hatching variant0.001177Highly InformativeInherited
Worm Phenotype (WP)cell fusion variant0.09344Highly InformativeInherited
Worm Phenotype (WP)lineage variant0.3712Highly InformativeInherited
Worm Phenotype (WP)P granule defective0.3786Highly InformativeInherited
Worm Phenotype (WP)germline proliferation variant0.9409Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)metabolism and growth0.4533Least InformativeInherited
Yeast Phenotype (YP)intracellular transport0.0016InformativeInherited
Yeast Phenotype (YP)protein transport0.0004295Highly InformativeDirect
Yeast Phenotype (YP)protein/peptide distribution0.0006738Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0.03167Least InformativeInherited
Fly Phenotype (FP)lethal - all die before end of P-stage0.1491Moderately InformativeInherited

Document: FP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0.00000000003664Least InformativeDirect
Xenopus ANatomical entity (XAN)trunk0.00005405Least InformativeDirect
Xenopus ANatomical entity (XAN)cavitated compound organ0.002924Least InformativeInherited
Xenopus ANatomical entity (XAN)nervous system0.003363Least InformativeInherited
Xenopus ANatomical entity (XAN)testis0.000000000000005863Moderately InformativeDirect
Xenopus ANatomical entity (XAN)germ line cell0.2651Moderately InformativeInherited
Xenopus ANatomical entity (XAN)anatomical entity in vitro0.0009445InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0.00006064Least InformativeDirect
Plant ANatomical entity (PAN)sporangium0.0003785Least InformativeDirect
Plant ANatomical entity (PAN)whole plant0.03801Least InformativeInherited
Plant ANatomical entity (PAN)microsporophyll0.09366Least InformativeInherited
Plant ANatomical entity (PAN)bud0.0001215Highly InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0.0005923Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0.000909Least InformativeDirect
Plant structure DEvelopment stage (PDE)pollen development stage0.0002532Moderately InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0.000000000005371Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases0.4992Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Aminoacyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0.00003431Moderately InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0.02028Moderately InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0.00000000008691InformativeDirect
Enzyme Commission (EC)Omega peptidases0.000001108InformativeDirect
Enzyme Commission (EC)RING-type E3 ubiquitin transferase0.00003498InformativeDirect
Enzyme Commission (EC)Acting on CH or CH(2) groups0.005757InformativeInherited
Enzyme Commission (EC)Miscellaneous0Highly InformativeDirect
Enzyme Commission (EC)Acting on ether bonds0Highly InformativeDirect
Enzyme Commission (EC)HECT-type E3 ubiquitin transferase0.00000001435Highly InformativeDirect
Enzyme Commission (EC)Aminopeptidases0.02049Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentPhycobilisome0.0000000004007Moderately InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 44 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a ARM repeat domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 44 hidden Markov models representing the ARM repeat superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]