SUPERFAMILY 1.75 HMM library and genome assignments server

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ARM repeat superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   alpha-alpha superhelix [ 48370] (24)
Superfamily:   ARM repeat [ 48371] (23)
Families:   Armadillo repeat [ 48372] (6)
  Clathrin adaptor core protein [ 74771] (2)
  HEAT repeat [ 48385] (2)
  MIF4G domain-like [ 100908] (5)
  PHAT domain [ 89129]
  Mo25 protein [ 101407]
  Leukotriene A4 hydrolase C-terminal domain [ 63608]
  Clathrin heavy chain proximal leg segment [ 48390]
  Clathrin heavy-chain linker domain [ 48393]
  Leucine-rich repeat variant [ 48396]
  Phoshoinositide 3-kinase (PI3K) helical domain [ 48399]
  Pumilio repeat [ 63611]
  Regulatory subunit H of the V-type ATPase [ 63614]
  PBS lyase HEAT-like repeat [ 101410] (2)
  BC3264-like [ 109965] (2)
  Eukaryotic translation initiation factor 3 subunit 12, eIF3k, N-terminal domain [ 109968]
  Exportin HEAT-like repeat [ 117002]
  B56-like [ 140819]
  HspBP1 domain [ 140822]
  GUN4-associated domain [ 140825] (2)
  Diap1 N-terninal region-like [ 140830]
  Plakophilin 1 helical region [ 140833]
  RPA1889-like [ 158764]


Superfamily statistics
Genomes (2,503) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 147,501 479,904 107
Proteins 123,570 406,390 92


Functional annotation
General category General
Detailed category General

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0.01346Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases0.05767Least InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Omega peptidases0.0000001704Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0.00001023Moderately InformativeDirect
Enzyme Commission (EC)Acting on ether bonds0InformativeDirect
Enzyme Commission (EC)Miscellaneous (requires further characterization)0InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol 3-kinase0Highly InformativeDirect
Enzyme Commission (EC)Leukotriene-A(4) hydrolase0Highly InformativeDirect
Enzyme Commission (EC)1-phosphatidylinositol 4-kinase0Highly InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-4,5-bisphosphate 3-kinase0Highly InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-4-phosphate 3-kinase0.000000000000004166Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)gastrointestinal system disease0.5294Moderately InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Somatic mutation0.0004067InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the head0.007192Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature0.1104Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal muscle tone0.067Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of facial musculature0.5389Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging0.006898Least InformativeInherited
Mammalian Phenotype (MP)prenatal lethality0.001432Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.06373Moderately InformativeInherited
Mammalian Phenotype (MP)neoplasm0.2137Moderately InformativeInherited
Mammalian Phenotype (MP)increased urinary system tumor incidence0.001522Highly InformativeInherited
Mammalian Phenotype (MP)increased adenoma incidence0.1279Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell morphology variant0Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0Least InformativeDirect
Worm Phenotype (WP)cell development variant0.0000000000001309Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.000000000001338Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.000000001063Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.000001553Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.1169Least InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.0000000000004006Moderately InformativeDirect
Worm Phenotype (WP)apoptosis variant0.000000000475Moderately InformativeDirect
Worm Phenotype (WP)protein expression variant0.000000005447Moderately InformativeDirect
Worm Phenotype (WP)cell division variant0.004888Moderately InformativeInherited
Worm Phenotype (WP)germ cell morphology variant0.01974Moderately InformativeInherited
Worm Phenotype (WP)organism stress response variant0.03031Moderately InformativeInherited
Worm Phenotype (WP)reproductive system morphology variant0.05138Moderately InformativeInherited
Worm Phenotype (WP)gametogenesis variant0.09484Moderately InformativeInherited
Worm Phenotype (WP)cell component morphology variant0.332Moderately InformativeInherited
Worm Phenotype (WP)embryonic cell organization biogenesis variant0.00000001541InformativeDirect
Worm Phenotype (WP)cytokinesis variant emb0.000001381InformativeDirect
Worm Phenotype (WP)sick0.00001373InformativeDirect
Worm Phenotype (WP)pigmentation variant0.00006735InformativeDirect
Worm Phenotype (WP)oocyte physiology variant0.0001742InformativeDirect
Worm Phenotype (WP)germ cell cytoplasmic morphology variant0.1557InformativeInherited
Worm Phenotype (WP)embryonic arrest0.00004159Highly InformativeDirect
Worm Phenotype (WP)developmental morphology variant0.00005511Highly InformativeDirect
Worm Phenotype (WP)seam cell morphology variant0.00008255Highly InformativeDirect
Worm Phenotype (WP)sex determination variant0.0003001Highly InformativeDirect
Worm Phenotype (WP)RNAi response variant0.0003485Highly InformativeDirect
Worm Phenotype (WP)multiple nuclei0.0007072Highly InformativeDirect
Worm Phenotype (WP)hatching variant0.001267Highly InformativeInherited
Worm Phenotype (WP)cell fusion variant0.09404Highly InformativeInherited
Worm Phenotype (WP)P granule defective0.3616Highly InformativeInherited
Worm Phenotype (WP)lineage variant0.373Highly InformativeInherited
Worm Phenotype (WP)germline proliferation variant0.9448Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)metabolism and growth0.4533Least InformativeInherited
Yeast Phenotype (YP)intracellular transport0.0016InformativeInherited
Yeast Phenotype (YP)protein transport0.0004295Highly InformativeDirect
Yeast Phenotype (YP)protein/peptide distribution0.0006738Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0.0177Least InformativeInherited
Fly Phenotype (FP)lethal - all die before end of P-stage0.08256Moderately InformativeInherited

Document: FP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0.00000000004011Least InformativeDirect
Xenopus ANatomical entity (XAN)trunk0.00005002Least InformativeDirect
Xenopus ANatomical entity (XAN)cavitated compound organ0.002902Least InformativeInherited
Xenopus ANatomical entity (XAN)nervous system0.003178Least InformativeInherited
Xenopus ANatomical entity (XAN)testis0.000000000000005829Moderately InformativeDirect
Xenopus ANatomical entity (XAN)germ line cell0.2684Moderately InformativeInherited
Xenopus ANatomical entity (XAN)anatomical entity in vitro0.0009928InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0.00006064Least InformativeDirect
Plant ANatomical entity (PAN)sporangium0.0003785Least InformativeDirect
Plant ANatomical entity (PAN)whole plant0.03801Least InformativeInherited
Plant ANatomical entity (PAN)microsporophyll0.09366Least InformativeInherited
Plant ANatomical entity (PAN)bud0.0001215Highly InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0.0005923Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0.000909Least InformativeDirect
Plant structure DEvelopment stage (PDE)pollen development stage0.0002532Moderately InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0.000000000002299Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases0.4991Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0.00004331Moderately InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0.02049Moderately InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0.00000000009465InformativeDirect
Enzyme Commission (EC)Omega peptidases0.000001086InformativeDirect
Enzyme Commission (EC)RING-type E3 ubiquitin transferase0.00001247InformativeDirect
Enzyme Commission (EC)Acting on CH or CH(2) groups0.005936InformativeInherited
Enzyme Commission (EC)Miscellaneous0Highly InformativeDirect
Enzyme Commission (EC)Acting on ether bonds0Highly InformativeDirect
Enzyme Commission (EC)HECT-type E3 ubiquitin transferase0.0000000644Highly InformativeDirect
Enzyme Commission (EC)Aminopeptidases0.02038Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentPhycobilisome0.0000000003367Moderately InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 44 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a ARM repeat domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 44 hidden Markov models representing the ARM repeat superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]