SUPERFAMILY 1.75 HMM library and genome assignments server

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ARM repeat superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   alpha-alpha superhelix [ 48370] (24)
Superfamily:   ARM repeat [ 48371] (23)
Families:   Armadillo repeat [ 48372] (6)
  Clathrin adaptor core protein [ 74771] (2)
  HEAT repeat [ 48385] (2)
  MIF4G domain-like [ 100908] (5)
  PHAT domain [ 89129]
  Mo25 protein [ 101407]
  Leukotriene A4 hydrolase C-terminal domain [ 63608]
  Clathrin heavy chain proximal leg segment [ 48390]
  Clathrin heavy-chain linker domain [ 48393]
  Leucine-rich repeat variant [ 48396]
  Phoshoinositide 3-kinase (PI3K) helical domain [ 48399]
  Pumilio repeat [ 63611]
  Regulatory subunit H of the V-type ATPase [ 63614]
  PBS lyase HEAT-like repeat [ 101410] (2)
  BC3264-like [ 109965] (2)
  Eukaryotic translation initiation factor 3 subunit 12, eIF3k, N-terminal domain [ 109968]
  Exportin HEAT-like repeat [ 117002]
  B56-like [ 140819]
  HspBP1 domain [ 140822]
  GUN4-associated domain [ 140825] (2)
  Diap1 N-terninal region-like [ 140830]
  Plakophilin 1 helical region [ 140833]
  RPA1889-like [ 158764]


Superfamily statistics
Genomes (2,496) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 144,743 186,320 107
Proteins 121,281 161,583 92


Functional annotation
General category General
Detailed category General

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biological regulation0.0005680.000001209Least InformativeDirect
Biological Process (BP)biosynthetic process11Least InformativeInherited
Biological Process (BP)single-organism cellular process0.99920.3586Least InformativeInherited
Biological Process (BP)primary metabolic process11Least InformativeInherited
Biological Process (BP)heterocycle metabolic process11Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process11Least InformativeInherited
Biological Process (BP)macromolecule metabolic process0.7630.09629Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process11Least InformativeInherited
Biological Process (BP)cellular nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.0021130Least InformativeInherited
Biological Process (BP)reproduction0.00010280.000000001838Moderately InformativeDirect
Biological Process (BP)macromolecule localization0.00000000079340.00000000000001068Moderately InformativeDirect
Biological Process (BP)cellular developmental process0.000035190.000000931Moderately InformativeDirect
Biological Process (BP)cellular localization0.00000000000016690Moderately InformativeDirect
Biological Process (BP)regulation of localization10.7024Moderately InformativeInherited
Biological Process (BP)multi-organism process0.056830.4307Moderately InformativeInherited
Biological Process (BP)organic substance transport0.00060380.0081Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.94310.1802Moderately InformativeInherited
Biological Process (BP)regulation of nitrogen compound metabolic process0.20730.8446Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process11Moderately InformativeInherited
Biological Process (BP)regulation of cellular metabolic process0.27751Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.12490.0086Moderately InformativeInherited
Biological Process (BP)regulation of biosynthetic process0.50881Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.62910.0000000001432Moderately InformativeInherited
Biological Process (BP)single-organism transport0.12321Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.67021Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.039621Moderately InformativeInherited
Biological Process (BP)system development0.97011Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process10.02012Moderately InformativeInherited
Biological Process (BP)RNA metabolic process0.18090.3126Moderately InformativeInherited
Biological Process (BP)cellular catabolic process10.000289Moderately InformativeInherited
Biological Process (BP)organelle organization0.74340Moderately InformativeInherited
Biological Process (BP)microtubule-based process0.000037990InformativeDirect
Biological Process (BP)posttranscriptional regulation of gene expression0.00017450InformativeDirect
Biological Process (BP)cell cycle process0.000000000070430InformativeDirect
Biological Process (BP)single organism reproductive process0.0000033150.0000000001958InformativeDirect
Biological Process (BP)multi-organism reproductive process0.0001610.00009684InformativeDirect
Biological Process (BP)single-organism intracellular transport0.000000000075560.00000000003185InformativeDirect
Biological Process (BP)regulation of cell cycle0.0023960.0000000000009723InformativeInherited
Biological Process (BP)symbiosis, encompassing mutualism through parasitism0.17691InformativeInherited
Biological Process (BP)regulation of protein localization0.36760.0806InformativeInherited
Biological Process (BP)regulation of cellular localization0.076630.1053InformativeInherited
Biological Process (BP)positive regulation of transport0.77871InformativeInherited
Biological Process (BP)multi-organism cellular process0.084521InformativeInherited
Biological Process (BP)protein targeting0.02760.925InformativeInherited
Biological Process (BP)protein localization to organelle0.0052420.1425InformativeInherited
Biological Process (BP)negative regulation of nitrogen compound metabolic process0.90280.2348InformativeInherited
Biological Process (BP)multicellular organism reproduction0.0026110.188InformativeInherited
Biological Process (BP)regulation of cellular amide metabolic process0.017750.0000000000000372InformativeInherited
Biological Process (BP)negative regulation of biosynthetic process0.70280.7819InformativeInherited
Biological Process (BP)negative regulation of gene expression0.751InformativeInherited
Biological Process (BP)negative regulation of cellular protein metabolic process0.18170.0001234InformativeInherited
Biological Process (BP)peptidyl-amino acid modification0.000035790.1687InformativeInherited
Biological Process (BP)generation of neurons0.15541InformativeInherited
Biological Process (BP)nucleocytoplasmic transport00.3235InformativeInherited
Biological Process (BP)nucleobase-containing compound catabolic process0.017820.000009003InformativeInherited
Biological Process (BP)cellular macromolecule catabolic process0.0057070.0000000002377InformativeInherited
Biological Process (BP)cytoskeleton organization0.010370.06124InformativeInherited
Biological Process (BP)cell cycle checkpoint0.00024640.0001851Highly InformativeDirect
Biological Process (BP)microtubule cytoskeleton organization0.0000025720.0001551Highly InformativeDirect
Biological Process (BP)RNA catabolic process0.00049730.00000001229Highly InformativeDirect
Biological Process (BP)protein import00Highly InformativeDirect
Biological Process (BP)negative regulation of translation0.0004130.0000008303Highly InformativeDirect
Biological Process (BP)pigmentation0.00044210.00005998Highly InformativeDirect
Biological Process (BP)regulation of RNA stability0.00059060.0000002942Highly InformativeDirect
Biological Process (BP)protein targeting to nucleus0.00000000000046760.00000000005739Highly InformativeDirect
Biological Process (BP)cell division0.000026610Highly InformativeDirect
Biological Process (BP)single-organism nuclear import0.00000000000012410Highly InformativeDirect
Biological Process (BP)regulation of cell division0.069170.000000001961Highly InformativeInherited
Biological Process (BP)viral life cycle0.000041420.1851Highly InformativeInherited
Biological Process (BP)positive regulation of intracellular transport0.03260.422Highly InformativeInherited
Biological Process (BP)positive regulation of cellular protein localization0.070850.8452Highly InformativeInherited
Biological Process (BP)regulation of protein import into nucleus0.013670.02384Highly InformativeInherited
Biological Process (BP)peptidyl-lysine modification0.00016990.3856Highly InformativeInherited
Biological Process (BP)cell proliferation0.029850.01402Highly InformativeInherited
Biological Process (BP)mRNA metabolic process0.004920.00003291Highly InformativeInherited
Molecular Function (MF)binding0.00000023810Least InformativeDirect
Molecular Function (MF)protein binding0.0000000000026730Moderately InformativeDirect
Molecular Function (MF)molecular function regulator0.00000082160.000000000001377Moderately InformativeDirect
Molecular Function (MF)oxidoreductase activity11Moderately InformativeInherited
Molecular Function (MF)transporter activity0.9421Moderately InformativeInherited
Molecular Function (MF)amide binding0.036370.2837InformativeInherited
Molecular Function (MF)protein transporter activity0.00000024220Highly InformativeDirect
Molecular Function (MF)phosphatase regulator activity0.000000000013490.00000001723Highly InformativeDirect
Molecular Function (MF)monooxygenase activity0.00000000010160.2863Highly InformativeInherited
Molecular Function (MF)oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge0.000000017430.6422Highly InformativeInherited
Molecular Function (MF)peptide binding0.0031410.007071Highly InformativeInherited
Cellular Component (CC)protein complex0.89990.00000000000003961Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.052110.000000002378Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.30760.3986Least InformativeInherited
Cellular Component (CC)non-membrane-bounded organelle0.0048560.0000000000003326Least InformativeInherited
Cellular Component (CC)nuclear part0.0000078650.00000000000007446Moderately InformativeDirect
Cellular Component (CC)cytoskeleton0.10620.0006238Moderately InformativeInherited
Cellular Component (CC)organelle envelope0.77090.1725Moderately InformativeInherited
Cellular Component (CC)nuclear envelope0.00050730.000000000000001578InformativeDirect
Cellular Component (CC)microtubule cytoskeleton0.0017720.0000003206InformativeInherited
Cellular Component (CC)chromosome0.22520.00000004817InformativeInherited
Cellular Component (CC)nuclear pore0.000013610Highly InformativeDirect
Cellular Component (CC)protein serine/threonine phosphatase complex00Highly InformativeDirect
Cellular Component (CC)peptidase complex0.65840.00000004611Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biological regulation 0.000001209 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 0.09629 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.3586 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) reproduction 0.000000001838 Moderately Informative Direct
Biological Process (BP) peptide metabolic process 0.0000001534 Moderately Informative Direct
Biological Process (BP) organelle organization 0 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.00000000000001068 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0.000289 Moderately Informative Direct
Biological Process (BP) cellular developmental process 0.000000931 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.0000000001432 Moderately Informative Direct
Biological Process (BP) cellular localization 0 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.7107 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.3126 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.4012 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.7024 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.1802 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.03486 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.4883 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) organophosphate biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.4307 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.3103 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 0.8446 Moderately Informative Inherited
Biological Process (BP) signaling 0.3211 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.0086 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) system development 1 Moderately Informative Inherited
Biological Process (BP) response to stress 0.1676 Moderately Informative Inherited
Biological Process (BP) cell communication 0.2149 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) single-organism transport 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) gene expression 0.07685 Moderately Informative Inherited
Biological Process (BP) amide biosynthetic process 0.3911 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.0081 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.02012 Moderately Informative Inherited
Biological Process (BP) phospholipid metabolic process 0.000000001585 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0.00003895 Informative Direct
Biological Process (BP) microtubule-based process 0 Informative Direct
Biological Process (BP) posttranscriptional regulation of gene expression 0 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.000000000009254 Informative Direct
Biological Process (BP) cell cycle process 0 Informative Direct
Biological Process (BP) actin filament-based process 0.000002699 Informative Direct
Biological Process (BP) negative regulation of cellular protein metabolic process 0.0001234 Informative Direct
Biological Process (BP) regulation of organelle organization 0.00001835 Informative Direct
Biological Process (BP) regulation of cellular amide metabolic process 0.0000000000000372 Informative Direct
Biological Process (BP) cellular macromolecular complex assembly 0.0000001241 Informative Direct
Biological Process (BP) nucleobase-containing compound catabolic process 0.000009003 Informative Direct
Biological Process (BP) intracellular signal transduction 0.0003454 Informative Direct
Biological Process (BP) locomotion 0.0001102 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.00000000000003235 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0.0000000002377 Informative Direct
Biological Process (BP) single organism reproductive process 0.0000000001958 Informative Direct
Biological Process (BP) multi-organism reproductive process 0.00009684 Informative Direct
Biological Process (BP) glycerolipid metabolic process 0.0000000003017 Informative Direct
Biological Process (BP) organelle fission 0.0000000008577 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0.0002194 Informative Direct
Biological Process (BP) regulation of cell cycle 0.0000000000009723 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0.000007162 Informative Direct
Biological Process (BP) single-organism intracellular transport 0.00000000003185 Informative Direct
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0.9255 Informative Inherited
Biological Process (BP) regulation of protein localization 0.0806 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) regulation of cell proliferation 1 Informative Inherited
Biological Process (BP) multi-organism cellular process 1 Informative Inherited
Biological Process (BP) regulation of protein modification process 1 Informative Inherited
Biological Process (BP) transcription, DNA-templated 0.6981 Informative Inherited
Biological Process (BP) cellular response to DNA damage stimulus 0.003065 Informative Inherited
Biological Process (BP) cellular component morphogenesis 1 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) response to nitrogen compound 0.3248 Informative Inherited
Biological Process (BP) response to organic cyclic compound 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.003962 Informative Inherited
Biological Process (BP) proteolysis 0.6588 Informative Inherited
Biological Process (BP) regulation of cellular localization 0.1053 Informative Inherited
Biological Process (BP) positive regulation of transport 1 Informative Inherited
Biological Process (BP) system process 0.826 Informative Inherited
Biological Process (BP) cell development 0.4762 Informative Inherited
Biological Process (BP) pigment metabolic process 0.7823 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) regulation of catabolic process 0.1453 Informative Inherited
Biological Process (BP) regulation of cell differentiation 1 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.001343 Informative Inherited
Biological Process (BP) protein targeting 0.925 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 1 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 0.9251 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.3805 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 0.1567 Informative Inherited
Biological Process (BP) animal organ morphogenesis 1 Informative Inherited
Biological Process (BP) growth 0.02134 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.02151 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 0.3155 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.1687 Informative Inherited
Biological Process (BP) post-embryonic development 0.00911 Informative Inherited
Biological Process (BP) organelle assembly 0.4178 Informative Inherited
Biological Process (BP) ribonucleoprotein complex biogenesis 0.043 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.3656 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.237 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.9457 Informative Inherited
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.4643 Informative Inherited
Biological Process (BP) positive regulation of gene expression 0.9526 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.06124 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.188 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.2654 Informative Inherited
Biological Process (BP) monocarboxylic acid biosynthetic process 1 Informative Inherited
Biological Process (BP) phosphorylation 0.03158 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.7819 Informative Inherited
Biological Process (BP) negative regulation of gene expression 1 Informative Inherited
Biological Process (BP) central nervous system development 0.4498 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 1 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.006449 Informative Inherited
Biological Process (BP) cell death 0.01926 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.8126 Informative Inherited
Biological Process (BP) embryo development 0.8683 Informative Inherited
Biological Process (BP) regulation of growth 0.6027 Informative Inherited
Biological Process (BP) behavior 0.3583 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.2348 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.09757 Informative Inherited
Biological Process (BP) secondary metabolic process 1 Informative Inherited
Biological Process (BP) fatty acid metabolic process 1 Informative Inherited
Biological Process (BP) protein localization to organelle 0.1425 Informative Inherited
Biological Process (BP) nucleocytoplasmic transport 0.3235 Informative Inherited
Biological Process (BP) nitrogen compound transport 1 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 1 Informative Inherited
Biological Process (BP) ncRNA processing 0.04283 Informative Inherited
Biological Process (BP) cell cycle checkpoint 0.0001851 Highly Informative Direct
Biological Process (BP) microtubule cytoskeleton organization 0.0001551 Highly Informative Direct
Biological Process (BP) RNA catabolic process 0.00000001229 Highly Informative Direct
Biological Process (BP) translational initiation 0.0000000000007792 Highly Informative Direct
Biological Process (BP) autophagy 0.0000000001356 Highly Informative Direct
Biological Process (BP) mitotic nuclear division 0.000000003948 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 0 Highly Informative Direct
Biological Process (BP) germ cell development 0.0009272 Highly Informative Direct
Biological Process (BP) endomembrane system organization 0.000000266 Highly Informative Direct
Biological Process (BP) positive regulation of cell development 0.000297 Highly Informative Direct
Biological Process (BP) nucleobase-containing compound transport 0.0000008051 Highly Informative Direct
Biological Process (BP) cell growth 0.00006988 Highly Informative Direct
Biological Process (BP) mRNA metabolic process 0.00003291 Highly Informative Direct
Biological Process (BP) endosomal transport 0.00006779 Highly Informative Direct
Biological Process (BP) protein import 0 Highly Informative Direct
Biological Process (BP) negative regulation of translation 0.0000008303 Highly Informative Direct
Biological Process (BP) lipid modification 0.000001532 Highly Informative Direct
Biological Process (BP) response to nutrient levels 0.000004709 Highly Informative Direct
Biological Process (BP) cell junction assembly 0.000003498 Highly Informative Direct
Biological Process (BP) pigmentation 0.00005998 Highly Informative Direct
Biological Process (BP) regulation of RNA stability 0.0000002942 Highly Informative Direct
Biological Process (BP) positive regulation of GTPase activity 0.0000000001479 Highly Informative Direct
Biological Process (BP) positive regulation of cellular component biogenesis 0.00000001544 Highly Informative Direct
Biological Process (BP) protein targeting to nucleus 0.00000000005739 Highly Informative Direct
Biological Process (BP) phosphatidylinositol metabolic process 0.00000000005997 Highly Informative Direct
Biological Process (BP) regulation of DNA metabolic process 0.0006778 Highly Informative Direct
Biological Process (BP) establishment of RNA localization 0.0000000000006221 Highly Informative Direct
Biological Process (BP) protein polymerization 0.0001911 Highly Informative Direct
Biological Process (BP) chromosome organization 0.00006239 Highly Informative Direct
Biological Process (BP) cell division 0 Highly Informative Direct
Biological Process (BP) regulation of cell division 0.000000001961 Highly Informative Direct
Biological Process (BP) establishment of organelle localization 0.0000000001669 Highly Informative Direct
Biological Process (BP) negative regulation of chromosome segregation 0.0002133 Highly Informative Direct
Biological Process (BP) ribonucleoprotein complex localization 0.0003685 Highly Informative Direct
Biological Process (BP) cellular response to external stimulus 0.00000001148 Highly Informative Direct
Biological Process (BP) nuclear chromosome segregation 0.00000000004106 Highly Informative Direct
Biological Process (BP) single-organism nuclear import 0 Highly Informative Direct
Biological Process (BP) regulation of protein modification by small protein conjugation or removal 0.0002888 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.3021 Highly Informative Inherited
Biological Process (BP) regulation of chromosome organization 0.6086 Highly Informative Inherited
Biological Process (BP) negative regulation of protein modification process 0.1342 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.001985 Highly Informative Inherited
Biological Process (BP) positive regulation of cell adhesion 0.6037 Highly Informative Inherited
Biological Process (BP) vesicle localization 0.5016 Highly Informative Inherited
Biological Process (BP) viral life cycle 0.1851 Highly Informative Inherited
Biological Process (BP) negative regulation of mitotic cell cycle 0.25 Highly Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle phase transition 0.1482 Highly Informative Inherited
Biological Process (BP) actin filament organization 0.09076 Highly Informative Inherited
Biological Process (BP) cellular component assembly involved in morphogenesis 1 Highly Informative Inherited
Biological Process (BP) actomyosin structure organization 1 Highly Informative Inherited
Biological Process (BP) muscle structure development 1 Highly Informative Inherited
Biological Process (BP) cellular response to organonitrogen compound 0.06553 Highly Informative Inherited
Biological Process (BP) response to alcohol 0.4841 Highly Informative Inherited
Biological Process (BP) lipid homeostasis 0.01228 Highly Informative Inherited
Biological Process (BP) neuron development 1 Highly Informative Inherited
Biological Process (BP) cell projection organization 0.01037 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.422 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular protein localization 0.8452 Highly Informative Inherited
Biological Process (BP) regulation of protein import into nucleus 0.02384 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.1026 Highly Informative Inherited
Biological Process (BP) gliogenesis 0.2812 Highly Informative Inherited
Biological Process (BP) meiotic cell cycle process 0.01201 Highly Informative Inherited
Biological Process (BP) cell proliferation 0.01402 Highly Informative Inherited
Biological Process (BP) brain development 0.5984 Highly Informative Inherited
Biological Process (BP) microtubule-based movement 0.001142 Highly Informative Inherited
Biological Process (BP) anatomical structure homeostasis 0.01005 Highly Informative Inherited
Biological Process (BP) negative regulation of growth 1 Highly Informative Inherited
Biological Process (BP) positive regulation of catabolic process 0.003842 Highly Informative Inherited
Biological Process (BP) regulation of protein catabolic process 0.618 Highly Informative Inherited
Biological Process (BP) chemotaxis 0.06411 Highly Informative Inherited
Biological Process (BP) sensory organ morphogenesis 0.09929 Highly Informative Inherited
Biological Process (BP) glycerophospholipid biosynthetic process 0.08833 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.3776 Highly Informative Inherited
Biological Process (BP) appendage development 0.7629 Highly Informative Inherited
Biological Process (BP) nucleus organization 0.178 Highly Informative Inherited
Biological Process (BP) metamorphosis 0.04364 Highly Informative Inherited
Biological Process (BP) instar larval or pupal morphogenesis 0.6532 Highly Informative Inherited
Biological Process (BP) ribonucleoprotein complex subunit organization 0.2025 Highly Informative Inherited
Biological Process (BP) positive regulation of cell cycle process 0.7835 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.09688 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular signal transduction 0.2533 Highly Informative Inherited
Biological Process (BP) positive regulation of nervous system development 0.9196 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.772 Highly Informative Inherited
Biological Process (BP) icosanoid metabolic process 0.1106 Highly Informative Inherited
Biological Process (BP) unsaturated fatty acid biosynthetic process 0.02222 Highly Informative Inherited
Biological Process (BP) fatty acid derivative biosynthetic process 0.004153 Highly Informative Inherited
Biological Process (BP) cell maturation 0.6646 Highly Informative Inherited
Biological Process (BP) endocytosis 1 Highly Informative Inherited
Biological Process (BP) proteasomal protein catabolic process 0.8875 Highly Informative Inherited
Biological Process (BP) aging 0.006654 Highly Informative Inherited
Biological Process (BP) peptidyl-lysine modification 0.3856 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.3058 Highly Informative Inherited
Biological Process (BP) single-organism behavior 0.006613 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.01853 Highly Informative Inherited
Biological Process (BP) spermatogenesis 0.4526 Highly Informative Inherited
Biological Process (BP) vesicle organization 0.01513 Highly Informative Inherited
Biological Process (BP) modification-dependent protein catabolic process 0.7938 Highly Informative Inherited
Biological Process (BP) nuclear export 1 Highly Informative Inherited
Biological Process (BP) regulation of production of molecular mediator of immune response 0.3947 Highly Informative Inherited
Biological Process (BP) rRNA metabolic process 0.04748 Highly Informative Inherited
Biological Process (BP) nucleic acid phosphodiester bond hydrolysis 0.0958 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) protein binding 0 Moderately Informative Direct
Molecular Function (MF) molecular function regulator 0.000000000001377 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.4439 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) metal ion binding 1 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 0.4776 Moderately Informative Inherited
Molecular Function (MF) RNA binding 0.0000000000000102 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0.0000819 Informative Direct
Molecular Function (MF) zinc ion binding 0.00005684 Informative Direct
Molecular Function (MF) peptidase activity, acting on L-amino acid peptides 0.0007094 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.004761 Informative Inherited
Molecular Function (MF) kinase activity 0.01237 Informative Inherited
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) enzyme binding 0.281 Informative Inherited
Molecular Function (MF) metal ion transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) signal transducer activity 1 Informative Inherited
Molecular Function (MF) amide binding 0.2837 Informative Inherited
Molecular Function (MF) passive transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) molecular transducer activity 1 Informative Inherited
Molecular Function (MF) translation factor activity, RNA binding 0.000001224 Highly Informative Direct
Molecular Function (MF) exopeptidase activity 0 Highly Informative Direct
Molecular Function (MF) protein transporter activity 0 Highly Informative Direct
Molecular Function (MF) tubulin binding 0.0002696 Highly Informative Direct
Molecular Function (MF) phosphatase regulator activity 0.00000001723 Highly Informative Direct
Molecular Function (MF) ubiquitin-like protein transferase activity 0.0000007232 Highly Informative Direct
Molecular Function (MF) small GTPase binding 0.000000002488 Highly Informative Direct
Molecular Function (MF) transmembrane signaling receptor activity 1 Highly Informative Inherited
Molecular Function (MF) monooxygenase activity 0.2863 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 0.6422 Highly Informative Inherited
Molecular Function (MF) ion channel activity 1 Highly Informative Inherited
Molecular Function (MF) gated channel activity 1 Highly Informative Inherited
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0.02554 Highly Informative Inherited
Molecular Function (MF) peptide binding 0.007071 Highly Informative Inherited
Molecular Function (MF) metallopeptidase activity 0.8619 Highly Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.0000000000003326 Least Informative Direct
Cellular Component (CC) protein complex 0.00000000000003961 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.000000002378 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.3986 Least Informative Inherited
Cellular Component (CC) membrane 0.2531 Least Informative Inherited
Cellular Component (CC) cytoskeleton 0.0006238 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0.0000002787 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.00000000000007446 Moderately Informative Direct
Cellular Component (CC) membrane protein complex 0.00002035 Moderately Informative Direct
Cellular Component (CC) whole membrane 0.000000000000127 Moderately Informative Direct
Cellular Component (CC) cell projection 0.1943 Moderately Informative Inherited
Cellular Component (CC) transferase complex 0.2247 Moderately Informative Inherited
Cellular Component (CC) cytosolic part 1 Moderately Informative Inherited
Cellular Component (CC) vesicle 0.1039 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 1 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 0.1725 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.008157 Moderately Informative Inherited
Cellular Component (CC) nuclear envelope 0.000000000000001578 Informative Direct
Cellular Component (CC) chromosome 0.00000004817 Informative Direct
Cellular Component (CC) Golgi apparatus 0 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 0.0000003206 Informative Direct
Cellular Component (CC) extrinsic component of membrane 0 Informative Direct
Cellular Component (CC) cell junction 0.00000000000000601 Informative Direct
Cellular Component (CC) site of polarized growth 0.0005602 Informative Direct
Cellular Component (CC) organelle subcompartment 0.0000001262 Informative Direct
Cellular Component (CC) cytoplasmic vesicle part 0.000000004774 Informative Direct
Cellular Component (CC) plasma membrane protein complex 0.0000007707 Informative Direct
Cellular Component (CC) cytoplasmic region 0.00004045 Informative Direct
Cellular Component (CC) side of membrane 0.06979 Informative Inherited
Cellular Component (CC) cilium 0.5227 Informative Inherited
Cellular Component (CC) plasma membrane region 1 Informative Inherited
Cellular Component (CC) cell projection part 0.1213 Informative Inherited
Cellular Component (CC) neuron projection 0.9581 Informative Inherited
Cellular Component (CC) nucleoplasm part 1 Informative Inherited
Cellular Component (CC) DNA-directed RNA polymerase complex 0.002052 Informative Inherited
Cellular Component (CC) ubiquitin ligase complex 0.8056 Informative Inherited
Cellular Component (CC) transport vesicle 0.05179 Informative Inherited
Cellular Component (CC) membrane region 0.04666 Informative Inherited
Cellular Component (CC) kinetochore 0.0001742 Highly Informative Direct
Cellular Component (CC) condensed chromosome 0.00000004207 Highly Informative Direct
Cellular Component (CC) nuclear pore 0 Highly Informative Direct
Cellular Component (CC) Golgi-associated vesicle 0 Highly Informative Direct
Cellular Component (CC) spindle 0.0000003782 Highly Informative Direct
Cellular Component (CC) cell-cell junction 0.00005768 Highly Informative Direct
Cellular Component (CC) protein serine/threonine phosphatase complex 0 Highly Informative Direct
Cellular Component (CC) vesicle membrane 0.0000000000004857 Highly Informative Direct
Cellular Component (CC) coated vesicle 0 Highly Informative Direct
Cellular Component (CC) midbody 0.000005942 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 0.000002833 Highly Informative Direct
Cellular Component (CC) anchoring junction 0.00000007008 Highly Informative Direct
Cellular Component (CC) peptidase complex 0.00000004611 Highly Informative Direct
Cellular Component (CC) growth cone 0.1076 Highly Informative Inherited
Cellular Component (CC) endocytic vesicle 0.04879 Highly Informative Inherited
Cellular Component (CC) polymeric cytoskeletal fiber 0.3264 Highly Informative Inherited
Cellular Component (CC) nuclear chromosome 0.06058 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

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EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0.01346Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases0.05767Least InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Omega peptidases0.0000001704Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0.00001023Moderately InformativeDirect
Enzyme Commission (EC)Acting on ether bonds0InformativeDirect
Enzyme Commission (EC)Miscellaneous (requires further characterization)0InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol 3-kinase0Highly InformativeDirect
Enzyme Commission (EC)Leukotriene-A(4) hydrolase0Highly InformativeDirect
Enzyme Commission (EC)1-phosphatidylinositol 4-kinase0Highly InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-4,5-bisphosphate 3-kinase0Highly InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-4-phosphate 3-kinase0.000000000000004166Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)gastrointestinal system disease0.5018Moderately InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

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HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Temporal pattern0.0002983Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.001201Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.1827Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.09639Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of forebrain morphology0.5706Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the autonomic nervous system0.04181Highly InformativeInherited
Phenotypic Abnormality (PA)Diminished movement0.07763Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

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MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging0.006915Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.8797Least InformativeInherited
Mammalian Phenotype (MP)prenatal lethality0.001145Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.04912Moderately InformativeInherited
Mammalian Phenotype (MP)neoplasm0.2132Moderately InformativeInherited
Mammalian Phenotype (MP)embryonic lethality0.0002625InformativeDirect
Mammalian Phenotype (MP)abnormal fluid regulation0.1244InformativeInherited
Mammalian Phenotype (MP)increased urinary system tumor incidence0.001652Highly InformativeInherited
Mammalian Phenotype (MP)increased adenoma incidence0.1201Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

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