SUPERFAMILY 1.75 HMM library and genome assignments server


ARM repeat superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   alpha-alpha superhelix [ 48370] (24)
Superfamily:   ARM repeat [ 48371] (23)
Families:   Armadillo repeat [ 48372] (6)
  Clathrin adaptor core protein [ 74771] (2)
  HEAT repeat [ 48385] (2)
  MIF4G domain-like [ 100908] (5)
  PHAT domain [ 89129]
  Mo25 protein [ 101407]
  Leukotriene A4 hydrolase C-terminal domain [ 63608]
  Clathrin heavy chain proximal leg segment [ 48390]
  Clathrin heavy-chain linker domain [ 48393]
  Leucine-rich repeat variant [ 48396]
  Phoshoinositide 3-kinase (PI3K) helical domain [ 48399]
  Pumilio repeat [ 63611]
  Regulatory subunit H of the V-type ATPase [ 63614]
  PBS lyase HEAT-like repeat [ 101410] (2)
  BC3264-like [ 109965] (2)
  Eukaryotic translation initiation factor 3 subunit 12, eIF3k, N-terminal domain [ 109968]
  Exportin HEAT-like repeat [ 117002]
  B56-like [ 140819]
  HspBP1 domain [ 140822]
  GUN4-associated domain [ 140825] (2)
  Diap1 N-terninal region-like [ 140830]
  Plakophilin 1 helical region [ 140833]
  RPA1889-like [ 158764]


Superfamily statistics
Genomes (1,938) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 125,826 118,822 107
Proteins 105,273 101,779 92


Functional annotation
General category General
Detailed category General

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism cellular process9.631e-050Least InformativeDirect
Biological Process (BP)regulation of cellular process5.498e-050.0003796Least InformativeDirect
Biological Process (BP)cellular component organization or biogenesis0.0006660Least InformativeDirect
Biological Process (BP)localization0.019010Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)single-organism metabolic process11Least InformativeInherited
Biological Process (BP)biosynthetic process11Least InformativeInherited
Biological Process (BP)protein metabolic process0.28090.3161Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.20190.1065Least InformativeInherited
Biological Process (BP)developmental process0.019920.0006175Least InformativeInherited
Biological Process (BP)multicellular organismal process0.24460.1004Least InformativeInherited
Biological Process (BP)reproduction0.00028339.028e-06Moderately InformativeDirect
Biological Process (BP)macromolecule localization2.195e-140Moderately InformativeDirect
Biological Process (BP)cellular localization2.788e-100Moderately InformativeDirect
Biological Process (BP)organic substance transport4.209e-052.956e-09Moderately InformativeDirect
Biological Process (BP)regulation of localization0.90680.3722Moderately InformativeInherited
Biological Process (BP)organ development11Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process11Moderately InformativeInherited
Biological Process (BP)immune system process11Moderately InformativeInherited
Biological Process (BP)regulation of cell communication0.76640.2148Moderately InformativeInherited
Biological Process (BP)regulation of signaling0.47830.05328Moderately InformativeInherited
Biological Process (BP)regulation of response to stimulus0.9430.6553Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.053130.0001161Moderately InformativeInherited
Biological Process (BP)regulation of developmental process11Moderately InformativeInherited
Biological Process (BP)cell differentiation0.29041Moderately InformativeInherited
Biological Process (BP)nervous system development0.18960.01302Moderately InformativeInherited
Biological Process (BP)homeostatic process0.58181Moderately InformativeInherited
Biological Process (BP)cellular amino acid metabolic process0.47531Moderately InformativeInherited
Biological Process (BP)small molecule biosynthetic process0.80411Moderately InformativeInherited
Biological Process (BP)organonitrogen compound biosynthetic process0.85471Moderately InformativeInherited
Biological Process (BP)organelle organization0.19710Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.68447.914e-11Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.14021Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.93840.6426Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process11Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.99511Moderately InformativeInherited
Biological Process (BP)single-organism developmental process0.19051Moderately InformativeInherited
Biological Process (BP)tissue development0.24430.4105Moderately InformativeInherited
Biological Process (BP)protein transport9.05e-150InformativeDirect
Biological Process (BP)cell cycle process2.467e-050InformativeDirect
Biological Process (BP)regulation of protein localization0.00088024.001e-08InformativeDirect
Biological Process (BP)organ morphogenesis0.69451InformativeInherited
Biological Process (BP)tissue morphogenesis0.085730.01614InformativeInherited
Biological Process (BP)dephosphorylation0.0018090.1988InformativeInherited
Biological Process (BP)cell proliferation0.032150.9752InformativeInherited
Biological Process (BP)regulation of reproductive process0.31510.02693InformativeInherited
Biological Process (BP)positive regulation of multicellular organismal process0.70511InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis0.77490.5641InformativeInherited
Biological Process (BP)positive regulation of developmental process0.71841InformativeInherited
Biological Process (BP)tube development0.18960.1567InformativeInherited
Biological Process (BP)developmental process involved in reproduction0.17510.1493InformativeInherited
Biological Process (BP)reproductive system development0.20590.3656InformativeInherited
Biological Process (BP)nucleocytoplasmic transport1.195e-140.6017InformativeInherited
Biological Process (BP)cytoplasmic transport0.023050.3855InformativeInherited
Biological Process (BP)hematopoietic or lymphoid organ development0.50931InformativeInherited
Biological Process (BP)regulation of intracellular transport0.00014130.004752InformativeInherited
Biological Process (BP)cellular modified amino acid metabolic process0.00038460.6425InformativeInherited
Biological Process (BP)positive regulation of signal transduction0.41461InformativeInherited
Biological Process (BP)multicellular organismal homeostasis0.091990.8991InformativeInherited
Biological Process (BP)anatomical structure homeostasis0.16040.005834InformativeInherited
Biological Process (BP)sensory organ development0.0075180.006573InformativeInherited
Biological Process (BP)cytoskeleton organization0.084410.001013InformativeInherited
Biological Process (BP)microtubule-based process0.004080InformativeInherited
Biological Process (BP)embryonic morphogenesis0.032610.3159InformativeInherited
Biological Process (BP)anatomical structure formation involved in morphogenesis0.46190.1334InformativeInherited
Biological Process (BP)protein localization to organelle0.085690.7717InformativeInherited
Biological Process (BP)regulation of organelle organization0.25646.182e-07InformativeInherited
Biological Process (BP)cardiovascular system development0.25090.5778InformativeInherited
Biological Process (BP)peptidyl-amino acid modification0.0019110.2854InformativeInherited
Biological Process (BP)central nervous system development0.39770.4235InformativeInherited
Biological Process (BP)regulation of nervous system development0.11510.8919InformativeInherited
Biological Process (BP)regulation of cell development0.13130.4858InformativeInherited
Biological Process (BP)generation of neurons0.16111InformativeInherited
Biological Process (BP)negative regulation of developmental process0.79781InformativeInherited
Biological Process (BP)alpha-amino acid biosynthetic process0.00030890.7769InformativeInherited
Biological Process (BP)negative regulation of cellular component organization0.11371.404e-05InformativeInherited
Biological Process (BP)regulation of cell proliferation11InformativeInherited
Biological Process (BP)epithelium development0.012020.003356InformativeInherited
Biological Process (BP)chordate embryonic development11InformativeInherited
Biological Process (BP)establishment or maintenance of cell polarity0.00028071.28e-08Highly InformativeDirect
Biological Process (BP)protein import3.099e-150Highly InformativeDirect
Biological Process (BP)peptidyl-lysine modification6.598e-136.275e-05Highly InformativeDirect
Biological Process (BP)regulation of intracellular protein transport5.973e-076.377e-07Highly InformativeDirect
Biological Process (BP)protein localization to nucleus1.239e-060Highly InformativeDirect
Biological Process (BP)tube formation0.00028445.735e-08Highly InformativeDirect
Biological Process (BP)cellular modified amino acid biosynthetic process9.625e-120.0002064Highly InformativeDirect
Biological Process (BP)protein targeting to nucleus5.962e-090Highly InformativeDirect
Biological Process (BP)regulation of nucleocytoplasmic transport3.187e-075.223e-05Highly InformativeDirect
Biological Process (BP)eye morphogenesis0.00043237.002e-07Highly InformativeDirect
Biological Process (BP)nuclear import00Highly InformativeDirect
Biological Process (BP)stem cell proliferation6.571e-071.329e-06Highly InformativeDirect
Biological Process (BP)regulation of protein localization to nucleus3.442e-070.000135Highly InformativeDirect
Biological Process (BP)kidney development0.13880.1077Highly InformativeInherited
Biological Process (BP)protein dephosphorylation1.911e-050.02273Highly InformativeInherited
Biological Process (BP)epithelial cell development0.035140.6749Highly InformativeInherited
Biological Process (BP)gastrulation0.0062960.6352Highly InformativeInherited
Biological Process (BP)epidermis development0.0044070.0001508Highly InformativeInherited
Biological Process (BP)hair cycle process0.0012830.8327Highly InformativeInherited
Biological Process (BP)positive regulation of epithelial cell proliferation0.057460.1226Highly InformativeInherited
Biological Process (BP)cell fate commitment0.098920.937Highly InformativeInherited
Biological Process (BP)lung development0.011720.6988Highly InformativeInherited
Biological Process (BP)regulation of cellular response to growth factor stimulus0.00096260.5964Highly InformativeInherited
Biological Process (BP)regulation of epithelial cell differentiation0.0071290.004852Highly InformativeInherited
Biological Process (BP)microtubule cytoskeleton organization0.02960.01992Highly InformativeInherited
Biological Process (BP)mitotic cell cycle0.46540.9423Highly InformativeInherited
Biological Process (BP)protein complex localization0.13910.1262Highly InformativeInherited
Biological Process (BP)organelle localization0.11031Highly InformativeInherited
Biological Process (BP)limb morphogenesis0.012390.7035Highly InformativeInherited
Biological Process (BP)negative regulation of cell development0.025950.05624Highly InformativeInherited
Biological Process (BP)pattern specification process0.24010.4803Highly InformativeInherited
Biological Process (BP)neural precursor cell proliferation0.0032220.0002155Highly InformativeInherited
Biological Process (BP)regulation of microtubule polymerization or depolymerization0.43830.01054Highly InformativeInherited
Biological Process (BP)regulation of protein complex disassembly0.032533.029e-10Highly InformativeInherited
Biological Process (BP)negative regulation of cytoskeleton organization0.17594.821e-07Highly InformativeInherited
Biological Process (BP)regulation of organ morphogenesis0.018580.2925Highly InformativeInherited
Biological Process (BP)regulation of neural precursor cell proliferation0.0011168.802e-06Highly InformativeInherited
Biological Process (BP)positive regulation of cell differentiation0.13710.4216Highly InformativeInherited
Biological Process (BP)regulation of stem cell proliferation0.002110.001302Highly InformativeInherited
Biological Process (BP)epithelial tube morphogenesis0.27950.8068Highly InformativeInherited
Biological Process (BP)morphogenesis of embryonic epithelium0.012950.0006713Highly InformativeInherited
Molecular Function (MF)binding0.0015031.511e-11Least InformativeInherited
Molecular Function (MF)protein binding1.416e-090Moderately InformativeDirect
Molecular Function (MF)enzyme regulator activity0.0003745.642e-12Moderately InformativeDirect
Molecular Function (MF)oxidoreductase activity11Moderately InformativeInherited
Molecular Function (MF)transporter activity0.97260.9607Moderately InformativeInherited
Molecular Function (MF)protein transporter activity7.349e-090Highly InformativeDirect
Molecular Function (MF)phosphatase regulator activity1.695e-131.053e-06Highly InformativeDirect
Molecular Function (MF)monooxygenase activity3.12e-100.2189Highly InformativeInherited
Molecular Function (MF)oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge5.659e-070.7027Highly InformativeInherited
Molecular Function (MF)peptide binding0.024320.1532Highly InformativeInherited
Molecular Function (MF)transcription factor binding transcription factor activity0.0057570.05795Highly InformativeInherited
Cellular Component (CC)intracellular non-membrane-bounded organelle3.531e-051.41e-11Least InformativeDirect
Cellular Component (CC)membrane11Least InformativeInherited
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)protein complex0.026613.483e-11Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.18490.0001864Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.98830.7269Least InformativeInherited
Cellular Component (CC)nuclear part3.795e-062.227e-11Moderately InformativeDirect
Cellular Component (CC)intrinsic to membrane0.8051Moderately InformativeInherited
Cellular Component (CC)plasma membrane11Moderately InformativeInherited
Cellular Component (CC)cell projection0.012340.06119Moderately InformativeInherited
Cellular Component (CC)cytoskeleton0.89330.004917Moderately InformativeInherited
Cellular Component (CC)endomembrane system0.28452.89e-12Moderately InformativeInherited
Cellular Component (CC)organelle envelope0.92350.9374Moderately InformativeInherited
Cellular Component (CC)microtubule cytoskeleton1.029e-050InformativeDirect
Cellular Component (CC)integral to membrane0.69061InformativeInherited
Cellular Component (CC)cell projection part0.019540.03424InformativeInherited
Cellular Component (CC)cell junction0.0053280InformativeInherited
Cellular Component (CC)nuclear envelope0.0016563.023e-08InformativeInherited
Cellular Component (CC)trans-Golgi network3.181e-050Highly InformativeDirect
Cellular Component (CC)protein serine/threonine phosphatase complex00Highly InformativeDirect
Cellular Component (CC)CCR4-NOT complex7.546e-080.0005176Highly InformativeDirect
Cellular Component (CC)pore complex0.0001181.053e-12Highly InformativeDirect
Cellular Component (CC)spindle0.026471.728e-08Highly InformativeInherited
Cellular Component (CC)cell projection membrane0.0011362.524e-08Highly InformativeInherited
Cellular Component (CC)proteasome complex0.059725.755e-10Highly InformativeInherited
Cellular Component (CC)cell-cell junction0.2110.00125Highly InformativeInherited
Cellular Component (CC)adherens junction11Highly InformativeInherited
Cellular Component (CC)microtubule organizing center8.177e-060.00369Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)