SUPERFAMILY 1.75 HMM library and genome assignments server

ARM repeat superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   alpha-alpha superhelix [ 48370] (24)
Superfamily:   ARM repeat [ 48371] (23)
Families:   Armadillo repeat [ 48372] (6)
  Clathrin adaptor core protein [ 74771] (2)
  HEAT repeat [ 48385] (2)
  MIF4G domain-like [ 100908] (5)
  PHAT domain [ 89129]
  Mo25 protein [ 101407]
  Leukotriene A4 hydrolase C-terminal domain [ 63608]
  Clathrin heavy chain proximal leg segment [ 48390]
  Clathrin heavy-chain linker domain [ 48393]
  Leucine-rich repeat variant [ 48396]
  Phoshoinositide 3-kinase (PI3K) helical domain [ 48399]
  Pumilio repeat [ 63611]
  Regulatory subunit H of the V-type ATPase [ 63614]
  PBS lyase HEAT-like repeat [ 101410] (2)
  BC3264-like [ 109965] (2)
  Eukaryotic translation initiation factor 3 subunit 12, eIF3k, N-terminal domain [ 109968]
  Exportin HEAT-like repeat [ 117002]
  B56-like [ 140819]
  HspBP1 domain [ 140822]
  GUN4-associated domain [ 140825] (2)
  Diap1 N-terninal region-like [ 140830]
  Plakophilin 1 helical region [ 140833]
  RPA1889-like [ 158764]


Superfamily statistics
Genomes (2,495) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 144,633 186,320 107
Proteins 121,216 161,583 92


Functional annotation
General category General
Detailed category General

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular component organization or biogenesis0.00037640Least InformativeDirect
Biological Process (BP)regulation of cellular process0.0015250.00007699Least InformativeInherited
Biological Process (BP)positive regulation of biological process0.038760.1148Least InformativeInherited
Biological Process (BP)protein metabolic process0.24060.07993Least InformativeInherited
Biological Process (BP)developmental process0.0064540.000001395Least InformativeInherited
Biological Process (BP)localization0.016050Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)multicellular organismal process0.074570.006337Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.099520.01534Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.082140.3194Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process11Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)heterocycle metabolic process11Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process11Least InformativeInherited
Biological Process (BP)response to stimulus11Least InformativeInherited
Biological Process (BP)macromolecule localization0.00000000000010260Moderately InformativeDirect
Biological Process (BP)cellular localization0.000000000018880Moderately InformativeDirect
Biological Process (BP)organic substance transport0.000017530.00000001946Moderately InformativeDirect
Biological Process (BP)regulation of signal transduction0.00520.005145Moderately InformativeInherited
Biological Process (BP)positive regulation of response to stimulus11Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.88440.1834Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.10541Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process11Moderately InformativeInherited
Biological Process (BP)cell differentiation0.50011Moderately InformativeInherited
Biological Process (BP)reproductive process0.000032410.006982Moderately InformativeInherited
Biological Process (BP)single-organism organelle organization0.041610Moderately InformativeInherited
Biological Process (BP)organ development11Moderately InformativeInherited
Biological Process (BP)immune system process11Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.021180.03974Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process11Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.98071Moderately InformativeInherited
Biological Process (BP)regulation of biological quality10.3351Moderately InformativeInherited
Biological Process (BP)regulation of localization10.4185Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.3860Moderately InformativeInherited
Biological Process (BP)tissue development0.93121Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process0.36571Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process10.9326Moderately InformativeInherited
Biological Process (BP)nervous system development0.20260.00757Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.2810.0402Moderately InformativeInherited
Biological Process (BP)regulation of gene expression11Moderately InformativeInherited
Biological Process (BP)regulation of macromolecule biosynthetic process0.15681Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.091580.000000006349Moderately InformativeInherited
Biological Process (BP)RNA metabolic process0.54581Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process10.8313Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.71620.001868Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.61290.01319Moderately InformativeInherited
Biological Process (BP)protein transport0.0000000012390InformativeDirect
Biological Process (BP)cell cycle process0.000000057040InformativeDirect
Biological Process (BP)cellular process involved in reproduction in multicellular organism0.00034040.000002505InformativeDirect
Biological Process (BP)cell division0.00063140InformativeDirect
Biological Process (BP)single-organism cellular localization0.0000000000012640.0000000000002255InformativeDirect
Biological Process (BP)single-organism intracellular transport0.00000076180InformativeDirect
Biological Process (BP)positive regulation of cell death0.6680.9506InformativeInherited
Biological Process (BP)regulation of apoptotic process0.55960.5294InformativeInherited
Biological Process (BP)regulation of cell proliferation11InformativeInherited
Biological Process (BP)regulation of cell development0.11110.06991InformativeInherited
Biological Process (BP)generation of neurons0.21081InformativeInherited
Biological Process (BP)cytoplasmic transport0.017370.001126InformativeInherited
Biological Process (BP)biological adhesion0.0038590.0002092InformativeInherited
Biological Process (BP)anatomical structure formation involved in morphogenesis0.65140.2113InformativeInherited
Biological Process (BP)dephosphorylation0.019660.8254InformativeInherited
Biological Process (BP)organ morphogenesis0.80111InformativeInherited
Biological Process (BP)epithelium development0.14740.003323InformativeInherited
Biological Process (BP)cell proliferation0.010670.044InformativeInherited
Biological Process (BP)tube development0.25260.8186InformativeInherited
Biological Process (BP)reproductive structure development0.25280.6641InformativeInherited
Biological Process (BP)cytoskeleton organization0.11690.0001409InformativeInherited
Biological Process (BP)microtubule-based process0.0015840InformativeInherited
Biological Process (BP)organelle localization0.2470.7148InformativeInherited
Biological Process (BP)regulation of nervous system development0.16620.1051InformativeInherited
Biological Process (BP)hematopoietic or lymphoid organ development0.54041InformativeInherited
Biological Process (BP)gland development0.17610.003023InformativeInherited
Biological Process (BP)multicellular organismal homeostasis0.13050.9635InformativeInherited
Biological Process (BP)anatomical structure homeostasis0.19970.0008451InformativeInherited
Biological Process (BP)sensory organ development0.018160.04976InformativeInherited
Biological Process (BP)positive regulation of multicellular organismal process11InformativeInherited
Biological Process (BP)embryonic morphogenesis0.04880.6733InformativeInherited
Biological Process (BP)protein localization to organelle0.059120.1702InformativeInherited
Biological Process (BP)regulation of protein localization0.0038530.00000009385InformativeInherited
Biological Process (BP)regulation of intracellular transport0.00086450.007863InformativeInherited
Biological Process (BP)leukocyte activation0.43930.169InformativeInherited
Biological Process (BP)negative regulation of developmental process0.97291InformativeInherited
Biological Process (BP)cardiovascular system development0.25340.7082InformativeInherited
Biological Process (BP)cellular component movement0.26550.000005186InformativeInherited
Biological Process (BP)locomotion0.18970.00007949InformativeInherited
Biological Process (BP)localization of cell0.34411InformativeInherited
Biological Process (BP)central nervous system development0.41270.5973InformativeInherited
Biological Process (BP)peptidyl-amino acid modification0.00067740.6998InformativeInherited
Biological Process (BP)negative regulation of biosynthetic process0.017921InformativeInherited
Biological Process (BP)negative regulation of cellular protein metabolic process0.97270.0001698InformativeInherited
Biological Process (BP)negative regulation of multicellular organismal process11InformativeInherited
Biological Process (BP)regulation of organelle organization0.23110InformativeInherited
Biological Process (BP)negative regulation of cellular component organization0.22950.00000005656InformativeInherited
Biological Process (BP)posttranscriptional regulation of gene expression0.0014680.00000000007709InformativeInherited
Biological Process (BP)nucleobase-containing compound catabolic process0.46750.8858InformativeInherited
Biological Process (BP)cellular macromolecule catabolic process0.0022930.0000000001536InformativeInherited
Biological Process (BP)cellular component morphogenesis0.93351InformativeInherited
Biological Process (BP)tissue morphogenesis0.19190.003603InformativeInherited
Biological Process (BP)embryo development ending in birth or egg hatching0.05650.006345InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis0.37310.04657InformativeInherited
Biological Process (BP)positive regulation of developmental process0.43740.8116InformativeInherited
Biological Process (BP)mRNA catabolic process0.00085620.000000001387Highly InformativeDirect
Biological Process (BP)regulation of translation0.00072810.0000000000003261Highly InformativeDirect
Biological Process (BP)establishment or maintenance of cell polarity0.000034620Highly InformativeDirect
Biological Process (BP)protein import00Highly InformativeDirect
Biological Process (BP)peptidyl-lysine modification0.000000026310.0008859Highly InformativeDirect
Biological Process (BP)cell junction organization0.00095870.000000000001435Highly InformativeDirect
Biological Process (BP)protein targeting to nucleus0.000000000089630Highly InformativeDirect
Biological Process (BP)regulation of nucleocytoplasmic transport0.00000019360.00000007221Highly InformativeDirect
Biological Process (BP)eye morphogenesis0.00054680.000001948Highly InformativeDirect
Biological Process (BP)stem cell proliferation0.00000052080.000007552Highly InformativeDirect
Biological Process (BP)epithelial tube formation0.00003710.00000000004795Highly InformativeDirect
Biological Process (BP)regulation of protein localization to nucleus0.00000047940.000001116Highly InformativeDirect
Biological Process (BP)single-organism nuclear import0.0000000000000032510Highly InformativeDirect
Biological Process (BP)positive regulation of apoptotic signaling pathway0.00076360.1985Highly InformativeInherited
Biological Process (BP)regulation of organ morphogenesis0.014290.3161Highly InformativeInherited
Biological Process (BP)cell adhesion0.0025090.1025Highly InformativeInherited
Biological Process (BP)protein dephosphorylation0.00010930.05593Highly InformativeInherited
Biological Process (BP)epidermis development0.011980.002858Highly InformativeInherited
Biological Process (BP)hair cycle process0.0028310.5223Highly InformativeInherited
Biological Process (BP)positive regulation of epithelial cell proliferation0.057530.1695Highly InformativeInherited
Biological Process (BP)regulation of reproductive process0.0030170.002623Highly InformativeInherited
Biological Process (BP)mesenchyme development0.0095670.6881Highly InformativeInherited
Biological Process (BP)respiratory tube development0.021130.8014Highly InformativeInherited
Biological Process (BP)respiratory system development0.023730.01058Highly InformativeInherited
Biological Process (BP)regulation of cellular response to growth factor stimulus0.0013190.7214Highly InformativeInherited
Biological Process (BP)negative regulation of nervous system development0.04930.008542Highly InformativeInherited
Biological Process (BP)regulation of epithelial cell differentiation0.013550.004804Highly InformativeInherited
Biological Process (BP)limb morphogenesis0.0078850.9468Highly InformativeInherited
Biological Process (BP)T cell differentiation0.031060.05746Highly InformativeInherited
Biological Process (BP)negative regulation of cell differentiation0.92091Highly InformativeInherited
Biological Process (BP)telencephalon development0.12680.00001326Highly InformativeInherited
Biological Process (BP)glial cell differentiation0.15020.1357Highly InformativeInherited
Biological Process (BP)pattern specification process0.29510.4482Highly InformativeInherited
Biological Process (BP)neural precursor cell proliferation0.0028330.00005402Highly InformativeInherited
Biological Process (BP)regulation of microtubule polymerization or depolymerization0.37990.0005097Highly InformativeInherited
Biological Process (BP)regulation of protein complex disassembly0.063820.0000000000003599Highly InformativeInherited
Biological Process (BP)negative regulation of cytoskeleton organization0.16830.0001277Highly InformativeInherited
Biological Process (BP)kidney development0.22440.551Highly InformativeInherited
Biological Process (BP)epithelial cell development0.11741Highly InformativeInherited
Biological Process (BP)cell morphogenesis involved in differentiation0.37571Highly InformativeInherited
Biological Process (BP)regulation of neural precursor cell proliferation0.0025710.000002672Highly InformativeInherited
Biological Process (BP)positive regulation of neurogenesis0.057361Highly InformativeInherited
Biological Process (BP)morphogenesis of embryonic epithelium0.010190.004578Highly InformativeInherited
Biological Process (BP)cell fate commitment0.061070.9299Highly InformativeInherited
Biological Process (BP)DNA integrity checkpoint0.15580.5205Highly InformativeInherited
Molecular Function (MF)binding0.00000021910Least InformativeDirect
Molecular Function (MF)enzyme regulator activity0.000034020.000000001946Moderately InformativeDirect
Molecular Function (MF)oxidoreductase activity11Moderately InformativeInherited
Molecular Function (MF)transporter activity0.79380.7234Moderately InformativeInherited
Molecular Function (MF)amide binding0.099410.8309InformativeInherited
Molecular Function (MF)protein transporter activity0.0000000027010Highly InformativeDirect
Molecular Function (MF)phosphatase regulator activity0.0000000000024170.0000000348Highly InformativeDirect
Molecular Function (MF)cell adhesion molecule binding0.012230.05431Highly InformativeInherited
Molecular Function (MF)monooxygenase activity0.00000000038510.2663Highly InformativeInherited
Molecular Function (MF)oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge0.000000064170.6484Highly InformativeInherited
Molecular Function (MF)peptide binding0.02650.2973Highly InformativeInherited
Cellular Component (CC)non-membrane-bounded organelle0.000000095760Least InformativeDirect
Cellular Component (CC)intracellular organelle part0.0083560Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.30170.4245Least InformativeInherited
Cellular Component (CC)protein complex0.085920.0000000008179Least InformativeInherited
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)membrane10.3715Least InformativeInherited
Cellular Component (CC)nuclear part0.0000012880.00000000008937Moderately InformativeDirect
Cellular Component (CC)intrinsic component of membrane0.65681Moderately InformativeInherited
Cellular Component (CC)cell projection0.070640.07841Moderately InformativeInherited
Cellular Component (CC)plasma membrane part11Moderately InformativeInherited
Cellular Component (CC)cytoskeleton10.03198Moderately InformativeInherited
Cellular Component (CC)bounding membrane of organelle0.39860.0002531Moderately InformativeInherited
Cellular Component (CC)organelle envelope10.3343Moderately InformativeInherited
Cellular Component (CC)microtubule cytoskeleton0.000021490.0000000001548InformativeDirect
Cellular Component (CC)cell junction0.011810InformativeInherited
Cellular Component (CC)Golgi apparatus0.089180InformativeInherited
Cellular Component (CC)vacuolar part0.0096460.009029InformativeInherited
Cellular Component (CC)integral component of membrane0.66691InformativeInherited
Cellular Component (CC)nuclear envelope0.0074820.00000000001029InformativeInherited
Cellular Component (CC)trans-Golgi network0.00023680Highly InformativeDirect
Cellular Component (CC)protein serine/threonine phosphatase complex00Highly InformativeDirect
Cellular Component (CC)pore complex0.000055810Highly InformativeDirect
Cellular Component (CC)spindle0.08650.00000004385Highly InformativeInherited
Cellular Component (CC)cell projection membrane0.0075070.000001091Highly InformativeInherited
Cellular Component (CC)adherens junction11Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)