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Ankyrin repeat superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   beta-hairpin-alpha-hairpin repeat [ 74651] (2)
Superfamily:   Ankyrin repeat [ 48403]
Families:   Ankyrin repeat [ 48404] (17)


Superfamily statistics
Genomes (1,789) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 80,489 276,064 42
Proteins 69,282 232,456 42


Functional annotation
General category General
Detailed category Protein interaction

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides0.4016Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds0.1213Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)In linear amides0.000000001232Moderately InformativeDirect
Enzyme Commission (EC)Carboxylic ester hydrolases0.0008122Moderately InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides0.001342Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep1Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases0.3822Moderately InformativeInherited
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase0.000000000000344InformativeDirect
Enzyme Commission (EC)Diacylglycerol kinase0.0000000000002201Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.4142Least InformativeInherited
Disease Ontology (DO)benign neoplasm0.0209Moderately InformativeInherited
Disease Ontology (DO)organ system benign neoplasm0.181InformativeInherited
Disease Ontology (DO)skin hemangioma0.000004277Highly InformativeDirect
Disease Ontology (DO)rhabdomyosarcoma0.0006394Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the digestive system0.48Least InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.1045Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.1633Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the pancreas0.1462InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.4032Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.5585Least InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.411Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.5696Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.6272Moderately InformativeInherited
Mammalian Phenotype (MP)embryo phenotype0.7217Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal Peyer's patch morphology0.04965InformativeInherited
Mammalian Phenotype (MP)incomplete somite formation0.0002865Highly InformativeDirect
Mammalian Phenotype (MP)extramedullary hematopoiesis0.0005229Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.03676Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.4385Least InformativeInherited
Worm Phenotype (WP)organism stress response variant0.001749Moderately InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.02823Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.3223Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant1Moderately InformativeInherited
Worm Phenotype (WP)localized movement variant0.0002997InformativeDirect
Worm Phenotype (WP)forward locomotion variant0.0003136InformativeDirect
Worm Phenotype (WP)body posture variant0.0006068InformativeDirect
Worm Phenotype (WP)mechanosensation variant0.0009721InformativeDirect
Worm Phenotype (WP)locomotor coordination variant0.002046InformativeInherited
Worm Phenotype (WP)body width variant0.2153InformativeInherited
Worm Phenotype (WP)odorant negative chemotaxis defective0.000007144Highly InformativeDirect
Worm Phenotype (WP)octanol chemotaxis variant0.00005482Highly InformativeDirect
Worm Phenotype (WP)organism heat response variant0.0002734Highly InformativeDirect
Worm Phenotype (WP)fat0.0005394Highly InformativeDirect
Worm Phenotype (WP)body posture wavelength variant0.4098Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)cell cycle progression0.05809InformativeInherited

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)behavior defective0.000545Moderately InformativeDirect
Fly Phenotype (FP)sensory perception defective0.00000005015InformativeDirect
Fly Phenotype (FP)neurophysiology defective0.0000001106InformativeDirect
Fly Phenotype (FP)temperature response defective0.002622Highly InformativeInherited

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system subdivision0.1116Least InformativeInherited
Fly Anatomy (FA)nervous system0.1542Least InformativeInherited
Fly Anatomy (FA)adult0.1571Least InformativeInherited
Fly Anatomy (FA)somatic cell0.3695Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)sense organ0.07391Moderately InformativeInherited
Fly Anatomy (FA)tagmatic subdivision of integument0.1259Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.1657Moderately InformativeInherited
Fly Anatomy (FA)head0.1743Moderately InformativeInherited
Fly Anatomy (FA)adult segment0.2624Moderately InformativeInherited
Fly Anatomy (FA)neuron0.3417Moderately InformativeInherited
Fly Anatomy (FA)appendage0.4081Moderately InformativeInherited
Fly Anatomy (FA)adult external head0.008801InformativeInherited
Fly Anatomy (FA)adult procephalic segment0.04583InformativeInherited
Fly Anatomy (FA)mechanosensory system0.6748InformativeInherited
Fly Anatomy (FA)adult antennal sense organ0.001969Highly InformativeInherited
Fly Anatomy (FA)cholinergic neuron0.005292Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0.6901Least InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.4852Least InformativeInherited
Enzyme Commission (EC)Transferring phosphorus-containing groups1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Aminoacyltransferases0.000000008402Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.01128Moderately InformativeInherited
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds0.03158Moderately InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Moderately InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups1Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase0.000006377InformativeDirect
Enzyme Commission (EC)In linear amides0.00003048InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0.0003374InformativeDirect
Enzyme Commission (EC)In phosphorus-containing anhydrides0.001243InformativeInherited
Enzyme Commission (EC)Carboxylic ester hydrolases0.01471InformativeInherited
Enzyme Commission (EC)Pentosyltransferases0.05921InformativeInherited
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase0.0000000000001886Highly InformativeDirect
Enzyme Commission (EC)Diacylglycerol kinase (ATP)0.00000000003041Highly InformativeDirect
Enzyme Commission (EC)HECT-type E3 ubiquitin transferase0.00000007731Highly InformativeDirect

Document: EC annotation of SCOP domains

InterPro annotation
Cross references IPR002110 SSF48403 Protein matches
Abstract

The ankyrin repeat is one of the most common protein-protein interaction motifs in nature. Ankyrin repeats are tandemly repeated modules of about 33 amino acids. They occur in a large number of functionally diverse proteins mainly from eukaryotes. The few known examples from prokaryotes and viruses may be the result of horizontal gene transfers [PubMed8108379]. The repeat has been found in proteins of diverse function such as transcriptional initiators, cell-cycle regulators, cytoskeletal, ion transporters and signal transducers. The ankyrin fold appears to be defined by its structure rather than its function since there is no specific sequence or structure which is universally recognised by it.

The conserved fold of the ankyrin repeat unit is known from several crystal and solution structures [PubMed8875926, PubMed9353127, PubMed9461436, PubMed9865693]. Each repeat folds into a helix-loop-helix structure with a beta-hairpin/loop region projecting out from the helices at a 90o angle. The repeats stack together to form an L-shaped structure [PubMed8875926, PubMed12461176].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 46 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Ankyrin repeat domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 46 hidden Markov models representing the Ankyrin repeat superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]