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Ankyrin repeat superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   beta-hairpin-alpha-hairpin repeat [ 74651] (2)
Superfamily:   Ankyrin repeat [ 48403]
Families:   Ankyrin repeat [ 48404] (17)

Superfamily statistics
Genomes (1,789) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 80,489 0 42
Proteins 69,282 0 42

Functional annotation
General category General
Detailed category Protein interaction

Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides0.4016Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds0.1213Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)In linear amides0.000000001232Moderately InformativeDirect
Enzyme Commission (EC)Carboxylic ester hydrolases0.0008122Moderately InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides0.001342Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep1Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases0.3822Moderately InformativeInherited
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase0.000000000000344InformativeDirect
Enzyme Commission (EC)Diacylglycerol kinase0.0000000000002201Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.4148Least InformativeInherited
Disease Ontology (DO)benign neoplasm0.02078Moderately InformativeInherited
Disease Ontology (DO)organ system benign neoplasm0.1809InformativeInherited
Disease Ontology (DO)skin hemangioma0.000004217Highly InformativeDirect
Disease Ontology (DO)rhabdomyosarcoma0.0006339Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the digestive system0.4284Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.4409Least InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.08306Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.1698Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the spinal cord0.3277InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.4041Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.5592Least InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.4111Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.5696Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.6272Moderately InformativeInherited
Mammalian Phenotype (MP)embryo phenotype0.7207Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal Peyer's patch morphology0.04967InformativeInherited
Mammalian Phenotype (MP)incomplete somite formation0.0002869Highly InformativeDirect
Mammalian Phenotype (MP)extramedullary hematopoiesis0.0005236Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.02956Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.5191Least InformativeInherited
Worm Phenotype (WP)organism stress response variant0.001527Moderately InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.02695Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.296Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant1Moderately InformativeInherited
Worm Phenotype (WP)forward locomotion variant0.0002759InformativeDirect
Worm Phenotype (WP)chemotaxis variant0.0002932InformativeDirect
Worm Phenotype (WP)localized movement variant0.0002932InformativeDirect
Worm Phenotype (WP)body posture variant0.0006144InformativeDirect
Worm Phenotype (WP)locomotor coordination variant0.001996InformativeInherited
Worm Phenotype (WP)body width variant0.2274InformativeInherited
Worm Phenotype (WP)odorant negative chemotaxis defective0.00000722Highly InformativeDirect
Worm Phenotype (WP)octanol chemotaxis variant0.00005539Highly InformativeDirect
Worm Phenotype (WP)organism heat response variant0.0003558Highly InformativeDirect
Worm Phenotype (WP)fat0.0005466Highly InformativeDirect
Worm Phenotype (WP)body posture wavelength variant0.4098Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)cell cycle progression0.05888InformativeInherited

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)behavior defective0.0002728Moderately InformativeDirect
Fly Phenotype (FP)sensory perception defective0.00000002981InformativeDirect
Fly Phenotype (FP)neurophysiology defective0.000002475InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)anatomical group0.01408Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.1215Least InformativeInherited
Fly Anatomy (FA)adult0.1562Least InformativeInherited
Fly Anatomy (FA)nervous system0.2447Least InformativeInherited
Fly Anatomy (FA)somatic cell0.3973Least InformativeInherited
Fly Anatomy (FA)integumentary system0.5441Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)sensory neuron0.048Moderately InformativeInherited
Fly Anatomy (FA)sense organ0.07685Moderately InformativeInherited
Fly Anatomy (FA)tagmatic subdivision of integument0.1299Moderately InformativeInherited
Fly Anatomy (FA)adult head0.1611Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.1705Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.2498Moderately InformativeInherited
Fly Anatomy (FA)adult segment0.2644Moderately InformativeInherited
Fly Anatomy (FA)appendage0.4243Moderately InformativeInherited
Fly Anatomy (FA)adult external head0.008333InformativeInherited
Fly Anatomy (FA)adult procephalic segment0.04502InformativeInherited
Fly Anatomy (FA)mechanosensory system0.6342InformativeInherited
Fly Anatomy (FA)adult antennal sense organ0.001718Highly InformativeInherited
Fly Anatomy (FA)cholinergic neuron0.00919Highly InformativeInherited
Fly Anatomy (FA)multidendritic neuron0.3619Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)nervous system0.5844Least InformativeInherited
Zebrafish Anatomy (ZA)cell0.7292Least InformativeInherited
Zebrafish Anatomy (ZA)central nervous system0.6055Moderately InformativeInherited
Zebrafish Anatomy (ZA)anatomical cluster0.6267Moderately InformativeInherited
Zebrafish Anatomy (ZA)ventricular system0.06381Highly InformativeInherited
Zebrafish Anatomy (ZA)multi fate stem cell0.1511Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.6207Least InformativeInherited
Enzyme Commission (EC)Transferring phosphorus-containing groups1Least InformativeInherited
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds0.0172Moderately InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides0.07548Moderately InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase0.000005964InformativeDirect
Enzyme Commission (EC)In linear amides0.000007725InformativeDirect
Enzyme Commission (EC)In phosphorus-containing anhydrides0.0001226InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0.0003029InformativeDirect
Enzyme Commission (EC)Carboxylic ester hydrolases0.01429InformativeInherited
Enzyme Commission (EC)Pentosyltransferases0.05959InformativeInherited
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase0.0000000000001891Highly InformativeDirect
Enzyme Commission (EC)Diacylglycerol kinase (ATP)0.00000000003044Highly InformativeDirect
Enzyme Commission (EC)HECT-type E3 ubiquitin transferase0.0000005489Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processDifferentiation0Moderately InformativeDirect
Biological processUbl conjugation pathway0Moderately InformativeDirect
Biological processIon transport0.00000001133Moderately InformativeDirect
Biological processApoptosis0.0000001474Moderately InformativeDirect
Biological processHost-virus interaction0.0007837Moderately InformativeDirect
Biological processCell cycle0.05778Moderately InformativeInherited
Biological processMeiosis0InformativeDirect
Biological processAngiogenesis0.0000001207InformativeDirect
Biological processWnt signaling pathway0.000001184InformativeDirect
Biological processPlant defense0.00004679InformativeDirect
Biological processMitosis0.00019InformativeDirect
Biological processCalcium transport0Highly InformativeDirect
Biological processNotch signaling pathway0Highly InformativeDirect
Biological processRNA-mediated gene silencing0Highly InformativeDirect
Biological processInhibition of host NF-kappa-B by virus0Highly InformativeDirect
Biological processSpermatogenesis0.0000000000008742Highly InformativeDirect
Biological processHearing0.000000001964Highly InformativeDirect
Biological processExocytosis0.00000004341Highly InformativeDirect
Biological processPotassium transport0.001296Highly InformativeInherited
Cellular componentNucleus0Least InformativeDirect
Cellular componentMembrane0.000000001117Least InformativeDirect
Cellular componentCytoplasm0.7739Least InformativeInherited
Cellular componentGolgi apparatus0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentEndosome0Moderately InformativeDirect
Cellular componentCytoskeleton0.00000000002865Moderately InformativeDirect
Cellular componentChromosome0.0008759InformativeDirect
Cellular componentSynapse0.3504InformativeInherited
Cellular componentPostsynaptic cell membrane0.0000822Highly InformativeDirect
Coding sequence diversityAlternative splicing0.000002891Least InformativeDirect
DiseaseTumor suppressor0.00004832Moderately InformativeDirect
DomainRepeat0Least InformativeDirect
DomainCoiled coil0.0000000000001828Moderately InformativeDirect
DomainANK repeat0InformativeDirect
DomainSH3 domain0.00000001133InformativeDirect
DomainTPR repeat0.00001073Highly InformativeDirect
Molecular functionCalcium0.000000000002554Moderately InformativeDirect
Molecular functionLipid-binding0.00000000154Moderately InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationActivator0.0000000003228Moderately InformativeDirect
Post-translational modificationKinase1Moderately InformativeInherited
Post-translational modificationCalmodulin-binding0InformativeDirect
Post-translational modificationGTPase activation0InformativeDirect
Post-translational modificationIon channel0InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0.0000133InformativeDirect
Post-translational modificationActin-binding0.00004305InformativeDirect
Post-translational modificationToxin0.9981InformativeInherited
Post-translational modificationCalcium channel0Highly InformativeDirect
Post-translational modificationNeurotoxin0.05256Highly InformativeInherited
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationPalmitate0.00001203Moderately InformativeDirect
Post-translational modificationMethylation0.0003341Moderately InformativeDirect
Post-translational modificationHydroxylation0InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR002110 SSF48403 Protein matches

The ankyrin repeat is one of the most common protein-protein interaction motifs in nature. Ankyrin repeats are tandemly repeated modules of about 33 amino acids. They occur in a large number of functionally diverse proteins mainly from eukaryotes. The few known examples from prokaryotes and viruses may be the result of horizontal gene transfers [PubMed8108379]. The repeat has been found in proteins of diverse function such as transcriptional initiators, cell-cycle regulators, cytoskeletal, ion transporters and signal transducers. The ankyrin fold appears to be defined by its structure rather than its function since there is no specific sequence or structure which is universally recognised by it.

The conserved fold of the ankyrin repeat unit is known from several crystal and solution structures [PubMed8875926, PubMed9353127, PubMed9461436, PubMed9865693]. Each repeat folds into a helix-loop-helix structure with a beta-hairpin/loop region projecting out from the helices at a 90o angle. The repeats stack together to form an L-shaped structure [PubMed8875926, PubMed12461176].

InterPro database

PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 19 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Browse and view proteins in genomes which have different domain combinations including a Ankyrin repeat domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 19 hidden Markov models representing the Ankyrin repeat superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]