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Ankyrin repeat superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   beta-hairpin-alpha-hairpin repeat [ 74651] (2)
Superfamily:   Ankyrin repeat [ 48403]
Families:   Ankyrin repeat [ 48404] (17)


Superfamily statistics
Genomes (1,789) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 80,489 276,064 42
Proteins 69,282 232,456 42


Functional annotation
General category General
Detailed category Protein interaction

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides0.4016Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds0.1213Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)In linear amides0.000000001232Moderately InformativeDirect
Enzyme Commission (EC)Carboxylic ester hydrolases0.0008122Moderately InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides0.001342Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep1Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases0.3822Moderately InformativeInherited
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase0.000000000000344InformativeDirect
Enzyme Commission (EC)Diacylglycerol kinase0.0000000000002201Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.4148Least InformativeInherited
Disease Ontology (DO)benign neoplasm0.02078Moderately InformativeInherited
Disease Ontology (DO)organ system benign neoplasm0.1809InformativeInherited
Disease Ontology (DO)skin hemangioma0.000004217Highly InformativeDirect
Disease Ontology (DO)rhabdomyosarcoma0.0006339Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the digestive system0.4454Least InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.08739Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.1692Moderately InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.4036Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.5589Least InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.4111Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.5696Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.6272Moderately InformativeInherited
Mammalian Phenotype (MP)embryo phenotype0.7205Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal Peyer's patch morphology0.04966InformativeInherited
Mammalian Phenotype (MP)incomplete somite formation0.0002867Highly InformativeDirect
Mammalian Phenotype (MP)extramedullary hematopoiesis0.000523Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.03031Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.5233Least InformativeInherited
Worm Phenotype (WP)organism stress response variant0.00151Moderately InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.02752Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.2992Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant1Moderately InformativeInherited
Worm Phenotype (WP)forward locomotion variant0.0002709InformativeDirect
Worm Phenotype (WP)localized movement variant0.0002924InformativeDirect
Worm Phenotype (WP)chemotaxis variant0.0003031InformativeDirect
Worm Phenotype (WP)body posture variant0.0006133InformativeDirect
Worm Phenotype (WP)locomotor coordination variant0.001993InformativeInherited
Worm Phenotype (WP)body width variant0.2281InformativeInherited
Worm Phenotype (WP)odorant negative chemotaxis defective0.000007202Highly InformativeDirect
Worm Phenotype (WP)octanol chemotaxis variant0.00005521Highly InformativeDirect
Worm Phenotype (WP)organism heat response variant0.0003508Highly InformativeDirect
Worm Phenotype (WP)fat0.000538Highly InformativeDirect
Worm Phenotype (WP)body posture wavelength variant0.4098Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)cell cycle progression0.05888InformativeInherited

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)behavior defective0.0003378Moderately InformativeDirect
Fly Phenotype (FP)sensory perception defective0.00000003448InformativeDirect
Fly Phenotype (FP)neurophysiology defective0.000002778InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)anatomical group0.01219Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.1156Least InformativeInherited
Fly Anatomy (FA)adult0.151Least InformativeInherited
Fly Anatomy (FA)nervous system0.2326Least InformativeInherited
Fly Anatomy (FA)somatic cell0.3814Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)sense organ0.07125Moderately InformativeInherited
Fly Anatomy (FA)tagmatic subdivision of integument0.1244Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.1681Moderately InformativeInherited
Fly Anatomy (FA)head0.169Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.2464Moderately InformativeInherited
Fly Anatomy (FA)adult segment0.2524Moderately InformativeInherited
Fly Anatomy (FA)appendage0.4134Moderately InformativeInherited
Fly Anatomy (FA)neuron0.5542Moderately InformativeInherited
Fly Anatomy (FA)adult external head0.008241InformativeInherited
Fly Anatomy (FA)adult procephalic segment0.04116InformativeInherited
Fly Anatomy (FA)mechanosensory system0.6363InformativeInherited
Fly Anatomy (FA)adult antennal sense organ0.001656Highly InformativeInherited
Fly Anatomy (FA)cholinergic neuron0.009018Highly InformativeInherited
Fly Anatomy (FA)multidendritic neuron0.3546Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)nervous system0.5989Least InformativeInherited
Zebrafish Anatomy (ZA)cell0.7944Least InformativeInherited
Zebrafish Anatomy (ZA)anatomical cluster0.5821Moderately InformativeInherited
Zebrafish Anatomy (ZA)central nervous system0.6151Moderately InformativeInherited
Zebrafish Anatomy (ZA)ventricular system0.06297Highly InformativeInherited
Zebrafish Anatomy (ZA)multi fate stem cell0.1568Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.6229Least InformativeInherited
Enzyme Commission (EC)Transferring phosphorus-containing groups1Least InformativeInherited
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds0.01726Moderately InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides0.0752Moderately InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase0.000005953InformativeDirect
Enzyme Commission (EC)In linear amides0.000007705InformativeDirect
Enzyme Commission (EC)In phosphorus-containing anhydrides0.000123InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0.0003022InformativeDirect
Enzyme Commission (EC)Carboxylic ester hydrolases0.01442InformativeInherited
Enzyme Commission (EC)Pentosyltransferases0.05931InformativeInherited
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase0.0000000000001882Highly InformativeDirect
Enzyme Commission (EC)Diacylglycerol kinase (ATP)0.00000000003035Highly InformativeDirect
Enzyme Commission (EC)HECT-type E3 ubiquitin transferase0.0000004725Highly InformativeDirect

Document: EC annotation of SCOP domains

InterPro annotation
Cross references IPR002110 SSF48403 Protein matches
Abstract

The ankyrin repeat is one of the most common protein-protein interaction motifs in nature. Ankyrin repeats are tandemly repeated modules of about 33 amino acids. They occur in a large number of functionally diverse proteins mainly from eukaryotes. The few known examples from prokaryotes and viruses may be the result of horizontal gene transfers [PubMed8108379]. The repeat has been found in proteins of diverse function such as transcriptional initiators, cell-cycle regulators, cytoskeletal, ion transporters and signal transducers. The ankyrin fold appears to be defined by its structure rather than its function since there is no specific sequence or structure which is universally recognised by it.

The conserved fold of the ankyrin repeat unit is known from several crystal and solution structures [PubMed8875926, PubMed9353127, PubMed9461436, PubMed9865693]. Each repeat folds into a helix-loop-helix structure with a beta-hairpin/loop region projecting out from the helices at a 90o angle. The repeats stack together to form an L-shaped structure [PubMed8875926, PubMed12461176].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 19 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Ankyrin repeat domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 19 hidden Markov models representing the Ankyrin repeat superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]