SUPERFAMILY 1.75 HMM library and genome assignments server


Ankyrin repeat superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   beta-hairpin-alpha-hairpin repeat [ 74651] (2)
Superfamily:   Ankyrin repeat [ 48403]
Families:   Ankyrin repeat [ 48404] (17)


Superfamily statistics
Genomes (1,734) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 70,357 73,003 42
Proteins 60,629 62,198 42


Functional annotation
General category General
Detailed category Protein interaction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)localization10.6059Least InformativeInherited
Biological Process (BP)single-organism cellular process0.93150.4134Least InformativeInherited
Biological Process (BP)multicellular organismal process0.095710.00059Least InformativeInherited
Biological Process (BP)developmental process0.064930.1164Least InformativeInherited
Biological Process (BP)regulation of cellular process0.038121Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.00024590.1691Least InformativeInherited
Biological Process (BP)negative regulation of cellular process0.00010250.0001557Moderately InformativeDirect
Biological Process (BP)regulation of localization0.83120.009967Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.019570.5381Moderately InformativeInherited
Biological Process (BP)regulation of phosphate metabolic process10.02142Moderately InformativeInherited
Biological Process (BP)regulation of catalytic activity0.063520.4346Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.75240.9407Moderately InformativeInherited
Biological Process (BP)regulation of macromolecule biosynthetic process0.063121Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.14061Moderately InformativeInherited
Biological Process (BP)positive regulation of molecular function11Moderately InformativeInherited
Biological Process (BP)immune system process0.12010.792Moderately InformativeInherited
Biological Process (BP)single-organism developmental process0.0092655.227e-07Moderately InformativeInherited
Biological Process (BP)organ development0.58230.673Moderately InformativeInherited
Biological Process (BP)cellular localization0.56880.1046Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.58220.01743Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process0.28181Moderately InformativeInherited
Biological Process (BP)positive regulation of response to stimulus0.81031Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.17360.04005Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process0.00020821Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.0039640.6926Moderately InformativeInherited
Biological Process (BP)cell cycle process4.803e-061.732e-09InformativeDirect
Biological Process (BP)regulation of establishment of protein localization0.37480.009419InformativeInherited
Biological Process (BP)regulation of intracellular transport0.0056650.002137InformativeInherited
Biological Process (BP)negative regulation of catalytic activity0.0003250.01926InformativeInherited
Biological Process (BP)negative regulation of protein metabolic process0.00048350.007549InformativeInherited
Biological Process (BP)hematopoietic or lymphoid organ development4.141e-050.05743InformativeInherited
Biological Process (BP)regulation of intracellular protein kinase cascade0.5051InformativeInherited
Biological Process (BP)positive regulation of signal transduction0.50660.6512InformativeInherited
Biological Process (BP)regulation of cell cycle5.646e-070.3509InformativeInherited
Biological Process (BP)regulation of kinase activity4.003e-110.798InformativeInherited
Biological Process (BP)regulation of protein phosphorylation9.594e-091InformativeInherited
Biological Process (BP)negative regulation of intracellular transport0.00017252.548e-06Highly InformativeDirect
Biological Process (BP)negative regulation of phosphorylation1.365e-050.0002393Highly InformativeDirect
Biological Process (BP)mitotic cell cycle phase transition1.517e-104.026e-05Highly InformativeDirect
Biological Process (BP)negative regulation of cell cycle4.282e-070.0007778Highly InformativeDirect
Biological Process (BP)negative regulation of protein transport0.00070990.0001132Highly InformativeDirect
Biological Process (BP)maintenance of location1.371e-051.863e-10Highly InformativeDirect
Biological Process (BP)regulation of protein localization to nucleus0.00066480.0001215Highly InformativeDirect
Biological Process (BP)regulation of intracellular protein transport0.013382.209e-05Highly InformativeInherited
Biological Process (BP)negative regulation of protein modification process2.449e-060.0523Highly InformativeInherited
Biological Process (BP)cell cycle phase0.034410.07874Highly InformativeInherited
Biological Process (BP)positive regulation of sequence-specific DNA binding transcription factor activity0.00037380.1229Highly InformativeInherited
Biological Process (BP)regulation of nucleocytoplasmic transport7.268e-050.005724Highly InformativeInherited
Biological Process (BP)negative regulation of sequence-specific DNA binding transcription factor activity0.04310.01488Highly InformativeInherited
Biological Process (BP)regulation of cellular response to growth factor stimulus8.714e-070.5725Highly InformativeInherited
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)enzyme regulator activity0.00093870.002098Moderately InformativeInherited
Molecular Function (MF)enzyme inhibitor activity0.00013352.502e-05InformativeDirect
Molecular Function (MF)enzyme binding1.13e-104.245e-10InformativeDirect
Molecular Function (MF)protein kinase regulator activity02.98e-09Highly InformativeDirect
Molecular Function (MF)transcription factor binding1.053e-050.03891Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0.00059 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.1691 Least Informative Inherited
Biological Process (BP) localization 0.6059 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.4134 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) developmental process 0.1164 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) ion transport 1.954e-10 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 0.0005798 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.000396 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 5.227e-07 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.0001557 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.009967 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.4346 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 0.02142 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.5459 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.3256 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.6398 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.2449 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.6926 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.4803 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.5381 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.007348 Moderately Informative Inherited
Biological Process (BP) immune system process 0.792 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) system process 0.1603 Moderately Informative Inherited
Biological Process (BP) tissue development 0.2288 Moderately Informative Inherited
Biological Process (BP) reproduction 0.1741 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.01743 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.1046 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.04005 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cofactor metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.9407 Moderately Informative Inherited
Biological Process (BP) organ development 0.673 Moderately Informative Inherited
Biological Process (BP) sexual reproduction 4.638e-05 Informative Direct
Biological Process (BP) cell cycle process 1.732e-09 Informative Direct
Biological Process (BP) cell projection organization 3.361e-07 Informative Direct
Biological Process (BP) cellular component morphogenesis 2.395e-07 Informative Direct
Biological Process (BP) ncRNA metabolic process 0.0005335 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.0004428 Informative Direct
Biological Process (BP) single organism reproductive process 1.003e-07 Informative Direct
Biological Process (BP) multicellular organismal reproductive process 0.0004924 Informative Direct
Biological Process (BP) cellular process involved in reproduction 1.826e-05 Informative Direct
Biological Process (BP) regulation of nervous system development 0.0007319 Informative Direct
Biological Process (BP) transmembrane transport 4.46e-05 Informative Direct
Biological Process (BP) muscle tissue development 0.0001816 Informative Direct
Biological Process (BP) regulation of ion transport 0.6215 Informative Inherited
Biological Process (BP) regulation of establishment of protein localization 0.009419 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.002137 Informative Inherited
Biological Process (BP) protein transport 0.06105 Informative Inherited
Biological Process (BP) secretion by cell 0.1455 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.6641 Informative Inherited
Biological Process (BP) positive regulation of gene expression 0.9762 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.007549 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.01926 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 1 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 1 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.1035 Informative Inherited
Biological Process (BP) response to organonitrogen compound 1 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.4632 Informative Inherited
Biological Process (BP) response to bacterium 0.03147 Informative Inherited
Biological Process (BP) response to lipid 0.543 Informative Inherited
Biological Process (BP) metal ion transport 0.03499 Informative Inherited
Biological Process (BP) cardiovascular system development 0.5342 Informative Inherited
Biological Process (BP) generation of neurons 0.1629 Informative Inherited
Biological Process (BP) regulation of cell development 0.3519 Informative Inherited
Biological Process (BP) cation homeostasis 0.3811 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.5224 Informative Inherited
Biological Process (BP) chromosome organization 1 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.4452 Informative Inherited
Biological Process (BP) actin filament-based process 0.6915 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.03883 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.02528 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.006931 Informative Inherited
Biological Process (BP) regulation of system process 0.4392 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.05743 Informative Inherited
Biological Process (BP) reproductive structure development 1 Informative Inherited
Biological Process (BP) single-organism behavior 0.05836 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.0127 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) DNA metabolic process 0.02934 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 1 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.08606 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.06535 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.1751 Informative Inherited
Biological Process (BP) protein localization to organelle 1 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.04934 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.8027 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0.8287 Informative Inherited
Biological Process (BP) muscle structure development 0.002113 Informative Inherited
Biological Process (BP) epithelium development 0.4926 Informative Inherited
Biological Process (BP) positive regulation of immune system process 1 Informative Inherited
Biological Process (BP) regulation of defense response 0.2709 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) cellular component movement 1 Informative Inherited
Biological Process (BP) locomotion 0.9059 Informative Inherited
Biological Process (BP) regulation of nucleoside metabolic process 0.6422 Informative Inherited
Biological Process (BP) regulation of nucleotide catabolic process 0.4634 Informative Inherited
Biological Process (BP) regulation of purine nucleotide metabolic process 0.8912 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.6304 Informative Inherited
Biological Process (BP) positive regulation of transport 0.01898 Informative Inherited
Biological Process (BP) transmission of nerve impulse 0.08615 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.3988 Informative Inherited
Biological Process (BP) response to DNA damage stimulus 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.2675 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.6512 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.7784 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 1 Informative Inherited
Biological Process (BP) growth 0.004342 Informative Inherited
Biological Process (BP) regulation of locomotion 1 Informative Inherited
Biological Process (BP) regulation of cellular component movement 1 Informative Inherited
Biological Process (BP) cell-cell signaling 0.527 Informative Inherited
Biological Process (BP) regulation of growth 0.4271 Informative Inherited
Biological Process (BP) sensory organ development 1 Informative Inherited
Biological Process (BP) organ morphogenesis 0.5915 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.07369 Informative Inherited
Biological Process (BP) regulation of cell cycle 0.3509 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.5517 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 0.8767 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 1 Informative Inherited
Biological Process (BP) immune response 0.1114 Informative Inherited
Biological Process (BP) defense response 0.9279 Informative Inherited
Biological Process (BP) response to wounding 1 Informative Inherited
Biological Process (BP) cell activation 0.8809 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.798 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 1 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.8703 Informative Inherited
Biological Process (BP) DNA modification 0 Highly Informative Direct
Biological Process (BP) porphyrin-containing compound biosynthetic process 0.0002131 Highly Informative Direct
Biological Process (BP) cellular calcium ion homeostasis 0.0004889 Highly Informative Direct
Biological Process (BP) meiosis 7.357e-12 Highly Informative Direct
Biological Process (BP) spermatogenesis 1.005e-09 Highly Informative Direct
Biological Process (BP) muscle organ development 2.594e-06 Highly Informative Direct
Biological Process (BP) sensory perception 0.00015 Highly Informative Direct
Biological Process (BP) response to heat 0.0009149 Highly Informative Direct
Biological Process (BP) cell growth 5.533e-05 Highly Informative Direct
Biological Process (BP) protein ubiquitination 0.000607 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular transport 2.548e-06 Highly Informative Direct
Biological Process (BP) regulation of transporter activity 0.0002882 Highly Informative Direct
Biological Process (BP) regulation of intracellular protein transport 2.209e-05 Highly Informative Direct
Biological Process (BP) ion transmembrane transport 6.382e-06 Highly Informative Direct
Biological Process (BP) regulation of transmembrane transport 9.101e-06 Highly Informative Direct
Biological Process (BP) regulation of gene expression, epigenetic 2.428e-10 Highly Informative Direct
Biological Process (BP) lipoprotein metabolic process 1.667e-05 Highly Informative Direct
Biological Process (BP) negative regulation of phosphorylation 0.0002393 Highly Informative Direct
Biological Process (BP) mitotic cell cycle phase transition 4.026e-05 Highly Informative Direct
Biological Process (BP) negative regulation of cell cycle 0.0007778 Highly Informative Direct
Biological Process (BP) negative regulation of protein transport 0.0001132 Highly Informative Direct
Biological Process (BP) maintenance of location 1.863e-10 Highly Informative Direct
Biological Process (BP) regulation of ligase activity 0.0001025 Highly Informative Direct
Biological Process (BP) myeloid cell development 7.313e-06 Highly Informative Direct
Biological Process (BP) regulation of protein localization to nucleus 0.0001215 Highly Informative Direct
Biological Process (BP) negative regulation of mitotic cell cycle phase transition 0.0005971 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.5003 Highly Informative Inherited
Biological Process (BP) neuron projection development 0.01961 Highly Informative Inherited
Biological Process (BP) cell part morphogenesis 0.01806 Highly Informative Inherited
Biological Process (BP) developmental growth 0.01427 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 0.3294 Highly Informative Inherited
Biological Process (BP) regulation of synaptic transmission 0.01436 Highly Informative Inherited
Biological Process (BP) renal system development 0.1293 Highly Informative Inherited
Biological Process (BP) cell cycle phase 0.07874 Highly Informative Inherited
Biological Process (BP) positive regulation of transcription, DNA-dependent 0.5719 Highly Informative Inherited
Biological Process (BP) negative regulation of protein modification process 0.0523 Highly Informative Inherited
Biological Process (BP) cellular response to organic cyclic compound 0.09721 Highly Informative Inherited
Biological Process (BP) response to alkaloid 0.07965 Highly Informative Inherited
Biological Process (BP) response to lipopolysaccharide 0.009588 Highly Informative Inherited
Biological Process (BP) cellular response to biotic stimulus 0.001665 Highly Informative Inherited
Biological Process (BP) calcium ion transport 0.0782 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 1 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.006642 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.1792 Highly Informative Inherited
Biological Process (BP) protein methylation 1 Highly Informative Inherited
Biological Process (BP) histone modification 0.4219 Highly Informative Inherited
Biological Process (BP) regulation of protein ubiquitination 0.0106 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0.3544 Highly Informative Inherited
Biological Process (BP) positive regulation of sequence-specific DNA binding transcription factor activity 0.1229 Highly Informative Inherited
Biological Process (BP) actin filament organization 0.03732 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.06275 Highly Informative Inherited
Biological Process (BP) erythrocyte differentiation 0.02693 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.6111 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 0.01084 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.06765 Highly Informative Inherited
Biological Process (BP) positive regulation of cell differentiation 0.8988 Highly Informative Inherited
Biological Process (BP) regulation of myeloid cell differentiation 0.1214 Highly Informative Inherited
Biological Process (BP) regulation of organ morphogenesis 0.05354 Highly Informative Inherited
Biological Process (BP) DNA replication 1 Highly Informative Inherited
Biological Process (BP) regulation of nucleocytoplasmic transport 0.005724 Highly Informative Inherited
Biological Process (BP) regulation of cytokine biosynthetic process 0.01588 Highly Informative Inherited
Biological Process (BP) epidermal cell differentiation 0.01707 Highly Informative Inherited
Biological Process (BP) activation of immune response 0.7465 Highly Informative Inherited
Biological Process (BP) immune response-regulating signaling pathway 0.8757 Highly Informative Inherited
Biological Process (BP) positive regulation of defense response 0.5153 Highly Informative Inherited
Biological Process (BP) regulation of innate immune response 0.03339 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.9946 Highly Informative Inherited
Biological Process (BP) regulation of cell adhesion 0.1679 Highly Informative Inherited
Biological Process (BP) chemotaxis 0.8607 Highly Informative Inherited
Biological Process (BP) response to purine-containing compound 0.08323 Highly Informative Inherited
Biological Process (BP) regulation of Ras GTPase activity 0.8703 Highly Informative Inherited
Biological Process (BP) positive regulation of GTPase activity 0.05032 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 0.005359 Highly Informative Inherited
Biological Process (BP) cellular component assembly involved in morphogenesis 0.6857 Highly Informative Inherited
Biological Process (BP) regulation of actin cytoskeleton organization 0.7191 Highly Informative Inherited
Biological Process (BP) negative regulation of cytoskeleton organization 0.002093 Highly Informative Inherited
Biological Process (BP) negative regulation of sequence-specific DNA binding transcription factor activity 0.01488 Highly Informative Inherited
Biological Process (BP) regulation of response to biotic stimulus 0.3 Highly Informative Inherited
Biological Process (BP) regulation of multi-organism process 0.8618 Highly Informative Inherited
Biological Process (BP) regulation of microtubule polymerization or depolymerization 0.02155 Highly Informative Inherited
Biological Process (BP) regulation of protein complex assembly 0.8122 Highly Informative Inherited
Biological Process (BP) cell junction organization 0.03694 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.5725 Highly Informative Inherited
Biological Process (BP) regulation of vesicle-mediated transport 0.01033 Highly Informative Inherited
Biological Process (BP) regulation of G-protein coupled receptor protein signaling pathway 0.004865 Highly Informative Inherited
Biological Process (BP) negative regulation of locomotion 0.6046 Highly Informative Inherited
Biological Process (BP) negative regulation of cellular component movement 0.5574 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.3837 Highly Informative Inherited
Biological Process (BP) response to osmotic stress 0.3764 Highly Informative Inherited
Biological Process (BP) transition metal ion transport 1 Highly Informative Inherited
Biological Process (BP) glutamine family amino acid catabolic process 0.005585 Highly Informative Inherited
Biological Process (BP) protein glycosylation 0.7372 Highly Informative Inherited
Biological Process (BP) inflammatory response 0.568 Highly Informative Inherited
Biological Process (BP) protein import 0.1333 Highly Informative Inherited
Biological Process (BP) protein localization to nucleus 0.5678 Highly Informative Inherited
Biological Process (BP) protein targeting to nucleus 0.3389 Highly Informative Inherited
Biological Process (BP) nuclear import 0.2018 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transporter activity 0.0003522 Moderately Informative Direct
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) structural molecule activity 0.8301 Moderately Informative Inherited
Molecular Function (MF) enzyme regulator activity 0.002098 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 1 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) enzyme inhibitor activity 2.502e-05 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0.0004759 Informative Direct
Molecular Function (MF) ligase activity, forming carbon-nitrogen bonds 0.0002738 Informative Direct
Molecular Function (MF) enzyme binding 4.245e-10 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 3.174e-11 Informative Direct
Molecular Function (MF) inorganic cation transmembrane transporter activity 0.01051 Informative Inherited
Molecular Function (MF) lipid binding 0.1123 Informative Inherited
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring one-carbon groups 1 Informative Inherited
Molecular Function (MF) phosphatase activity 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 0.2484 Informative Inherited
Molecular Function (MF) enzyme activator activity 1 Informative Inherited
Molecular Function (MF) GTPase regulator activity 0.2719 Informative Inherited
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 0.02822 Informative Inherited
Molecular Function (MF) kinase activity 1 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 1 Informative Inherited
Molecular Function (MF) ion channel activity 0 Highly Informative Direct
Molecular Function (MF) small conjugating protein ligase activity 1.279e-06 Highly Informative Direct
Molecular Function (MF) protein kinase regulator activity 2.98e-09 Highly Informative Direct
Molecular Function (MF) alcohol binding 0.0002834 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0.03891 Highly Informative Inherited
Molecular Function (MF) glycolipid binding 0.001528 Highly Informative Inherited
Molecular Function (MF) S-adenosylmethionine-dependent methyltransferase activity 0.7294 Highly Informative Inherited
Molecular Function (MF) phosphoprotein phosphatase activity 0.4391 Highly Informative Inherited
Molecular Function (MF) ion gated channel activity 0.1571 Highly Informative Inherited
Molecular Function (MF) small GTPase regulator activity 0.7 Highly Informative Inherited
Molecular Function (MF) GTPase activator activity 0.1735 Highly Informative Inherited
Molecular Function (MF) transferase activity, transferring pentosyl groups 0.1095 Highly Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.01658 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) cell projection 2.171e-05 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0.9892 Moderately Informative Inherited
Cellular Component (CC) extracellular region part 1 Moderately Informative Inherited
Cellular Component (CC) ribonucleoprotein complex 0.4777 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.3142 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 0.05813 Moderately Informative Inherited
Cellular Component (CC) cell cortex 0.0007092 Informative Direct
Cellular Component (CC) contractile fiber part 7.746e-05 Informative Direct
Cellular Component (CC) synapse part 3.981e-06 Informative Direct
Cellular Component (CC) endosome 0.06823 Informative Inherited
Cellular Component (CC) Golgi apparatus 0.02443 Informative Inherited
Cellular Component (CC) neuron projection 0.002413 Informative Inherited
Cellular Component (CC) nucleoplasm part 1 Informative Inherited
Cellular Component (CC) cell-cell junction 1 Informative Inherited
Cellular Component (CC) actin cytoskeleton 0.3777 Informative Inherited
Cellular Component (CC) chromosome 1 Informative Inherited
Cellular Component (CC) Golgi membrane 1.524e-06 Highly Informative Direct
Cellular Component (CC) actin filament 0.0001691 Highly Informative Direct
Cellular Component (CC) adherens junction 1.836e-08 Highly Informative Direct
Cellular Component (CC) axon part 7.848e-07 Highly Informative Direct
Cellular Component (CC) cell-cell contact zone 3.817e-05 Highly Informative Direct
Cellular Component (CC) membrane raft 0.0001379 Highly Informative Direct
Cellular Component (CC) synaptic membrane 2.961e-11 Highly Informative Direct
Cellular Component (CC) protein serine/threonine phosphatase complex 0.04411 Highly Informative Inherited
Cellular Component (CC) endosomal part 0.01129 Highly Informative Inherited
Cellular Component (CC) recycling endosome 0.1946 Highly Informative Inherited
Cellular Component (CC) dendrite 0.8341 Highly Informative Inherited
Cellular Component (CC) neuron spine 0.4443 Highly Informative Inherited
Cellular Component (CC) transcription elongation factor complex 0.009492 Highly Informative Inherited
Cellular Component (CC) trans-Golgi network 0.2303 Highly Informative Inherited
Cellular Component (CC) transcription factor complex 1 Highly Informative Inherited
Cellular Component (CC) cell-substrate junction 0.2693 Highly Informative Inherited
Cellular Component (CC) replisome 0.00128 Highly Informative Inherited
Cellular Component (CC) nuclear chromosome part 0.7669 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

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EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides0.4016Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds0.1213Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)In linear amides1.232e-09Moderately InformativeDirect
Enzyme Commission (EC)Carboxylic ester hydrolases0.0008122Moderately InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides0.001342Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep1Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases0.3822Moderately InformativeInherited
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase3.44e-13InformativeDirect
Enzyme Commission (EC)Diacylglycerol kinase2.201e-13Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

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DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)benign neoplasm0.03266Moderately InformativeInherited
Disease Ontology (DO)organ system benign neoplasm0.2482InformativeInherited
Disease Ontology (DO)skin hemangioma5.121e-06Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

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MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.3591Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.5142Least InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.03733Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.173Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryogenesis/ development1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal Peyer's patch morphology0.04665InformativeInherited
Mammalian Phenotype (MP)abnormal skin appearance0.3233InformativeInherited
Mammalian Phenotype (MP)extramedullary hematopoiesis0.0002303Highly InformativeDirect
Mammalian Phenotype (MP)incomplete somite formation0.0003181Highly InformativeDirect
Mammalian Phenotype (MP)scaly skin0.0005936Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

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WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.01108Least InformativeInherited
Worm Phenotype (WP)chemical response variant0.9899Moderately InformativeInherited
Worm Phenotype (WP)organism stress response variant3.662e-05InformativeDirect
Worm Phenotype (WP)chemotaxis variant0.0001255InformativeDirect
Worm Phenotype (WP)negative chemotaxis variant0.01861Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)cell cycle progression0.05375InformativeInherited

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)sensory perception defective5.007e-09InformativeDirect
Fly Phenotype (FP)neurophysiology defective8.488e-07InformativeDirect
Fly Phenotype (FP)temperature response defective0.00559InformativeInherited
Fly Phenotype (FP)thermotaxis behavior defective4.832e-05Highly InformativeDirect
Fly Phenotype (FP)gravitaxis defective0.0005941Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

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FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system subdivision0.04611Least InformativeInherited
Fly Anatomy (FA)anatomical group0.109Least InformativeInherited
Fly Anatomy (FA)organ system0.2253Least InformativeInherited
Fly Anatomy (FA)cell0.2658Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)tagmatic subdivision of integument0.03114Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.09106Moderately InformativeInherited
Fly Anatomy (FA)neuron0.1372Moderately InformativeInherited
Fly Anatomy (FA)appendage0.3594Moderately InformativeInherited
Fly Anatomy (FA)sense organ0.4043Moderately InformativeInherited
Fly Anatomy (FA)adult segment0.6391Moderately InformativeInherited
Fly Anatomy (FA)head0.7456Moderately InformativeInherited
Fly Anatomy (FA)adult external head0.006048InformativeInherited
Fly Anatomy (FA)antennal segment0.05128InformativeInherited
Fly Anatomy (FA)appendage segment0.1228InformativeInherited
Fly Anatomy (FA)adult procephalic segment0.1958InformativeInherited
Fly Anatomy (FA)mechanosensory system0.5596InformativeInherited
Fly Anatomy (FA)antennal sense organ0.00474Highly InformativeInherited
Fly Anatomy (FA)chordotonal organ0.02405Highly InformativeInherited

Document: FA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

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EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.2465Least InformativeInherited
Enzyme Commission (EC)Transferring phosphorous-containing groups0.2732Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Acyltransferases4.58e-13Moderately InformativeDirect
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds0.0003632Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.4457Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases0.8636Moderately InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect
Enzyme Commission (EC)In linear amides9.449e-09InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase1.117e-06InformativeDirect
Enzyme Commission (EC)Carboxylic ester hydrolases0.0009037InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0.001528InformativeInherited
Enzyme Commission (EC)In phosphorous-containing anhydrides0.004493InformativeInherited
Enzyme Commission (EC)Pentosyltransferases0.009531InformativeInherited
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase1.265e-14Highly InformativeDirect
Enzyme Commission (EC)Diacylglycerol kinase (ATP)3.763e-12Highly InformativeDirect
Enzyme Commission (EC)Lysophospholipase5.1e-05Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

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