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Ankyrin repeat superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   beta-hairpin-alpha-hairpin repeat [ 74651] (2)
Superfamily:   Ankyrin repeat [ 48403]
Families:   Ankyrin repeat [ 48404] (17)


Superfamily statistics
Genomes (1,787) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 79,664 226,127 42
Proteins 68,588 190,359 42


Functional annotation
General category General
Detailed category Protein interaction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biological regulation0.020970.002089Least InformativeInherited
Biological Process (BP)single-organism cellular process10.8965Least InformativeInherited
Biological Process (BP)response to stimulus11Least InformativeInherited
Biological Process (BP)negative regulation of cellular process0.000019140.00001847Moderately InformativeDirect
Biological Process (BP)regulation of developmental process0.27520.01531Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.24080.0003157Moderately InformativeInherited
Biological Process (BP)regulation of response to stimulus0.048440.007593Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.024040.003854Moderately InformativeInherited
Biological Process (BP)regulation of signaling0.061210.000000004425Moderately InformativeInherited
Biological Process (BP)regulation of cell communication0.092430.0000001328Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process0.00073421Moderately InformativeInherited
Biological Process (BP)regulation of macromolecule biosynthetic process0.04580.861Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.075940.9132Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process0.33961Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.63310.009246Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.13720.04063Moderately InformativeInherited
Biological Process (BP)regulation of localization0.83390.02455Moderately InformativeInherited
Biological Process (BP)regulation of molecular function0.000000036040.004028Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.86491Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.0061420.02792Moderately InformativeInherited
Biological Process (BP)immune system process0.3281Moderately InformativeInherited
Biological Process (BP)system development0.017680.003746Moderately InformativeInherited
Biological Process (BP)cellular developmental process0.0021880.000000002557Moderately InformativeInherited
Biological Process (BP)cell communication0.067171Moderately InformativeInherited
Biological Process (BP)single organism signaling0.51850.8971Moderately InformativeInherited
Biological Process (BP)cell cycle process0.000018260.0000000004319InformativeDirect
Biological Process (BP)regulation of protein modification process0.000000083310.000006692InformativeDirect
Biological Process (BP)regulation of anatomical structure morphogenesis0.49620.198InformativeInherited
Biological Process (BP)regulation of transferase activity0.000073260.04077InformativeInherited
Biological Process (BP)regulation of cell cycle0.0000000013080.02064InformativeInherited
Biological Process (BP)regulation of growth0.00030780.04475InformativeInherited
Biological Process (BP)regulation of transcription, DNA-templated0.002910.03065InformativeInherited
Biological Process (BP)negative regulation of molecular function0.19620.3433InformativeInherited
Biological Process (BP)negative regulation of transport0.21840.1505InformativeInherited
Biological Process (BP)regulation of peptide transport0.10590.8073InformativeInherited
Biological Process (BP)regulation of establishment of protein localization0.54940.105InformativeInherited
Biological Process (BP)regulation of cellular localization0.011520.0001854InformativeInherited
Biological Process (BP)regulation of intracellular signal transduction0.77161InformativeInherited
Biological Process (BP)regulation of phosphorylation0.17230.4258InformativeInherited
Biological Process (BP)positive regulation of signal transduction0.3040.4266InformativeInherited
Biological Process (BP)cell surface receptor signaling pathway0.17860.03235InformativeInherited
Biological Process (BP)negative regulation of intracellular transport0.00007220.0001244Highly InformativeDirect
Biological Process (BP)positive regulation of growth0.000056680.000006139Highly InformativeDirect
Biological Process (BP)negative regulation of phosphate metabolic process00.0009227Highly InformativeDirect
Biological Process (BP)maintenance of location0.0000032250.0000002397Highly InformativeDirect
Biological Process (BP)regulation of cellular response to growth factor stimulus0.0000017140.6292Highly InformativeInherited
Biological Process (BP)regulation of sequence-specific DNA binding transcription factor activity0.000099130.0198Highly InformativeInherited
Biological Process (BP)negative regulation of establishment of protein localization0.022720.006258Highly InformativeInherited
Biological Process (BP)regulation of protein import into nucleus0.00010140.08969Highly InformativeInherited
Biological Process (BP)regulation of protein modification by small protein conjugation or removal0.059940.01906Highly InformativeInherited
Biological Process (BP)regulation of transmembrane receptor protein serine/threonine kinase signaling pathway0.00000046030.8864Highly InformativeInherited
Biological Process (BP)myeloid cell differentiation0.00010190.6355Highly InformativeInherited
Molecular Function (MF)binding10.5194Least InformativeInherited
Molecular Function (MF)molecular function regulator0.0024980.009095Moderately InformativeInherited
Molecular Function (MF)enzyme binding0.0000000085510.000001185InformativeDirect
Molecular Function (MF)enzyme inhibitor activity0.00000015720.009785InformativeInherited
Molecular Function (MF)protein kinase regulator activity0.000000000000002070.0000000001786Highly InformativeDirect
Molecular Function (MF)transcription factor binding0.01080.2931Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 0.0000003612 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.8965 Least Informative Inherited
Biological Process (BP) biological regulation 0.002089 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) ion transport 0.0000007347 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 0.000001057 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.0000000106 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 0.0000001328 Moderately Informative Direct
Biological Process (BP) regulation of signaling 0.000000004425 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.00001847 Moderately Informative Direct
Biological Process (BP) cellular developmental process 0.000000002557 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.0003157 Moderately Informative Direct
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.06911 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.004028 Moderately Informative Inherited
Biological Process (BP) single-organism transport 1 Moderately Informative Inherited
Biological Process (BP) response to biotic stimulus 0.3145 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.287 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.8941 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.4537 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.7557 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) protein complex biogenesis 0.7062 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.9935 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.009246 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.003854 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.04063 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.02455 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.1724 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.9132 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.007593 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.02792 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.1401 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.0492 Moderately Informative Inherited
Biological Process (BP) immune system process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.06277 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.001139 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.01531 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.861 Moderately Informative Inherited
Biological Process (BP) single organism signaling 0.8971 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.2548 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) system development 0.003746 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) nitrogen compound transport 1 Moderately Informative Inherited
Biological Process (BP) system process 0.00000000001509 Informative Direct
Biological Process (BP) behavior 0.00000000005818 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.0002175 Informative Direct
Biological Process (BP) cell cycle process 0.0000000004319 Informative Direct
Biological Process (BP) negative regulation of signaling 0.00004406 Informative Direct
Biological Process (BP) metal ion transport 0.00000003395 Informative Direct
Biological Process (BP) actin filament-based process 0.0002936 Informative Direct
Biological Process (BP) regulation of protein modification process 0.000006692 Informative Direct
Biological Process (BP) cellular component morphogenesis 0 Informative Direct
Biological Process (BP) growth 0.00002308 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.00000003331 Informative Direct
Biological Process (BP) single organism reproductive process 0.000635 Informative Direct
Biological Process (BP) multi-organism reproductive process 0.0000006753 Informative Direct
Biological Process (BP) cell development 0.00007361 Informative Direct
Biological Process (BP) regulation of nervous system development 0.0000003495 Informative Direct
Biological Process (BP) transmembrane transport 0.00008122 Informative Direct
Biological Process (BP) regulation of cellular localization 0.0001854 Informative Direct
Biological Process (BP) supramolecular fiber organization 0.0006918 Informative Direct
Biological Process (BP) regulation of transferase activity 0.04077 Informative Inherited
Biological Process (BP) regulation of cell cycle 0.02064 Informative Inherited
Biological Process (BP) regulation of system process 0.8697 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.2187 Informative Inherited
Biological Process (BP) mitotic cell cycle 1 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.06403 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.6298 Informative Inherited
Biological Process (BP) response to nitrogen compound 1 Informative Inherited
Biological Process (BP) response to bacterium 0.005042 Informative Inherited
Biological Process (BP) cellular response to lipid 0.1257 Informative Inherited
Biological Process (BP) regulation of transcription, DNA-templated 0.03065 Informative Inherited
Biological Process (BP) regulation of phosphorylation 0.4258 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 0.8191 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 1 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 1 Informative Inherited
Biological Process (BP) circulatory system development 0.2145 Informative Inherited
Biological Process (BP) ion homeostasis 0.02675 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.2504 Informative Inherited
Biological Process (BP) response to metal ion 0.8058 Informative Inherited
Biological Process (BP) protein oligomerization 0.08615 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.001275 Informative Inherited
Biological Process (BP) generation of neurons 0.02522 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.00477 Informative Inherited
Biological Process (BP) regulation of growth 0.04475 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.004275 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.2767 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.233 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.7947 Informative Inherited
Biological Process (BP) regulation of cell differentiation 0.01218 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.198 Informative Inherited
Biological Process (BP) negative regulation of molecular function 0.3433 Informative Inherited
Biological Process (BP) regulation of ion transport 0.4254 Informative Inherited
Biological Process (BP) positive regulation of transport 0.4987 Informative Inherited
Biological Process (BP) negative regulation of transport 0.1505 Informative Inherited
Biological Process (BP) regulation of peptide transport 0.8073 Informative Inherited
Biological Process (BP) regulation of cytokine production 1 Informative Inherited
Biological Process (BP) negative regulation of macromolecule biosynthetic process 0.535 Informative Inherited
Biological Process (BP) negative regulation of cellular biosynthetic process 0.8213 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.5083 Informative Inherited
Biological Process (BP) protein localization to organelle 0.4675 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.4337 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 1 Informative Inherited
Biological Process (BP) regulation of defense response 0.2702 Informative Inherited
Biological Process (BP) locomotion 0.9901 Informative Inherited
Biological Process (BP) regulation of establishment of protein localization 0.105 Informative Inherited
Biological Process (BP) regulation of transmembrane transport 0.1234 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.3712 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.002875 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.4266 Informative Inherited
Biological Process (BP) sensory organ development 1 Informative Inherited
Biological Process (BP) central nervous system development 1 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 1 Informative Inherited
Biological Process (BP) response to temperature stimulus 0.001158 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.4648 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.1638 Informative Inherited
Biological Process (BP) tissue development 0.1321 Informative Inherited
Biological Process (BP) movement of cell or subcellular component 1 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.7308 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.2259 Informative Inherited
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 0.2741 Informative Inherited
Biological Process (BP) positive regulation of gene expression 0.171 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 0.03235 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 1 Informative Inherited
Biological Process (BP) glutamine family amino acid metabolic process 0.00549 Informative Inherited
Biological Process (BP) DNA metabolic process 0.01029 Informative Inherited
Biological Process (BP) post-embryonic development 0.3032 Informative Inherited
Biological Process (BP) embryo development 0.4294 Informative Inherited
Biological Process (BP) intracellular protein transport 1 Informative Inherited
Biological Process (BP) single-organism intracellular transport 0.5782 Informative Inherited
Biological Process (BP) nuclear division 0.00000000003234 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 0.0000001069 Highly Informative Direct
Biological Process (BP) protein lipidation 0.00000003716 Highly Informative Direct
Biological Process (BP) response to heat 0.0001661 Highly Informative Direct
Biological Process (BP) response to mechanical stimulus 0.00000003201 Highly Informative Direct
Biological Process (BP) embryo development ending in birth or egg hatching 0.0000387 Highly Informative Direct
Biological Process (BP) cellular component assembly involved in morphogenesis 0.00000006018 Highly Informative Direct
Biological Process (BP) cell growth 0.000000000001827 Highly Informative Direct
Biological Process (BP) regulation of transmembrane transporter activity 0.0003022 Highly Informative Direct
Biological Process (BP) epithelial cell differentiation 0.00000005846 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular transport 0.0001244 Highly Informative Direct
Biological Process (BP) positive regulation of transporter activity 0.00001517 Highly Informative Direct
Biological Process (BP) regulation of membrane potential 0.0007721 Highly Informative Direct
Biological Process (BP) regulation of circadian rhythm 0.0006261 Highly Informative Direct
Biological Process (BP) positive regulation of ion transport 0.000142 Highly Informative Direct
Biological Process (BP) macromolecule methylation 0.000000000001229 Highly Informative Direct
Biological Process (BP) post-translational protein modification 0.0000000002612 Highly Informative Direct
Biological Process (BP) single-organism behavior 0 Highly Informative Direct
Biological Process (BP) DNA methylation or demethylation 0 Highly Informative Direct
Biological Process (BP) positive regulation of growth 0.000006139 Highly Informative Direct
Biological Process (BP) negative regulation of phosphate metabolic process 0.0009227 Highly Informative Direct
Biological Process (BP) neuron development 0.0002112 Highly Informative Direct
Biological Process (BP) appendage development 0.000528 Highly Informative Direct
Biological Process (BP) neurological system process 0.0002083 Highly Informative Direct
Biological Process (BP) maintenance of location 0.0000002397 Highly Informative Direct
Biological Process (BP) meiotic cell cycle 0.0000001173 Highly Informative Direct
Biological Process (BP) positive regulation of nervous system development 0.000001796 Highly Informative Direct
Biological Process (BP) developmental growth involved in morphogenesis 0.000000008272 Highly Informative Direct
Biological Process (BP) divalent metal ion transport 0 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0.0005455 Highly Informative Direct
Biological Process (BP) import into cell 0.000000001811 Highly Informative Direct
Biological Process (BP) inorganic cation transmembrane transport 0.00000000007688 Highly Informative Direct
Biological Process (BP) plasma membrane bounded cell projection organization 0 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 0.3725 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.6292 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.5875 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular protein localization 0.0162 Highly Informative Inherited
Biological Process (BP) cellular response to abiotic stimulus 0.02569 Highly Informative Inherited
Biological Process (BP) cellular response to organonitrogen compound 0.9514 Highly Informative Inherited
Biological Process (BP) response to organophosphorus 0.08625 Highly Informative Inherited
Biological Process (BP) response to molecule of bacterial origin 0.01202 Highly Informative Inherited
Biological Process (BP) anatomical structure homeostasis 0.005979 Highly Informative Inherited
Biological Process (BP) regulation of DNA-templated transcription in response to stress 0.002033 Highly Informative Inherited
Biological Process (BP) response to hypoxia 0.2887 Highly Informative Inherited
Biological Process (BP) cellular response to decreased oxygen levels 0.001001 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.5487 Highly Informative Inherited
Biological Process (BP) tube morphogenesis 0.002563 Highly Informative Inherited
Biological Process (BP) cellular calcium ion homeostasis 0.04442 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular component biogenesis 0.00294 Highly Informative Inherited
Biological Process (BP) actin filament organization 0.2645 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 1 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.8181 Highly Informative Inherited
Biological Process (BP) germ cell development 0.4537 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.02833 Highly Informative Inherited
Biological Process (BP) regulation of cell size 0.2634 Highly Informative Inherited
Biological Process (BP) regulation of sequence-specific DNA binding transcription factor activity 0.0198 Highly Informative Inherited
Biological Process (BP) negative regulation of establishment of protein localization 0.006258 Highly Informative Inherited
Biological Process (BP) regulation of protein import into nucleus 0.08969 Highly Informative Inherited
Biological Process (BP) response to osmotic stress 0.02244 Highly Informative Inherited
Biological Process (BP) regeneration 0.02664 Highly Informative Inherited
Biological Process (BP) wound healing 0.06508 Highly Informative Inherited
Biological Process (BP) post-embryonic animal morphogenesis 0.002754 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.6894 Highly Informative Inherited
Biological Process (BP) regulation of toll-like receptor signaling pathway 0.02675 Highly Informative Inherited
Biological Process (BP) chemotaxis 1 Highly Informative Inherited
Biological Process (BP) response to purine-containing compound 0.08742 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 0.02027 Highly Informative Inherited
Biological Process (BP) negative regulation of multi-organism process 0.436 Highly Informative Inherited
Biological Process (BP) regulation of protein modification by small protein conjugation or removal 0.01906 Highly Informative Inherited
Biological Process (BP) DNA replication 0.8664 Highly Informative Inherited
Biological Process (BP) regulation of microtubule-based process 0.06037 Highly Informative Inherited
Biological Process (BP) female gamete generation 1 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.8864 Highly Informative Inherited
Biological Process (BP) myeloid cell differentiation 0.6355 Highly Informative Inherited
Biological Process (BP) regulation of G-protein coupled receptor protein signaling pathway 0.01848 Highly Informative Inherited
Biological Process (BP) brain development 0.7062 Highly Informative Inherited
Biological Process (BP) protein modification by small protein conjugation 0.001052 Highly Informative Inherited
Biological Process (BP) muscle structure development 0.03482 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular signal transduction 0.09709 Highly Informative Inherited
Biological Process (BP) positive regulation of transcription, DNA-templated 0.01717 Highly Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.2046 Highly Informative Inherited
Biological Process (BP) glycoprotein metabolic process 1 Highly Informative Inherited
Biological Process (BP) macromolecule glycosylation 0.888 Highly Informative Inherited
Biological Process (BP) mitotic cell cycle phase transition 0.004483 Highly Informative Inherited
Biological Process (BP) protein import 0.3312 Highly Informative Inherited
Biological Process (BP) protein targeting to nucleus 0.2229 Highly Informative Inherited
Molecular Function (MF) binding 0.5194 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 1 Moderately Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 1 Moderately Informative Inherited
Molecular Function (MF) structural molecule activity 0.02333 Moderately Informative Inherited
Molecular Function (MF) transporter activity 0.004856 Moderately Informative Inherited
Molecular Function (MF) molecular function regulator 0.009095 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) phospholipid binding 0.0001404 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0.000000000009759 Informative Direct
Molecular Function (MF) enzyme binding 0.000001185 Informative Direct
Molecular Function (MF) passive transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) amide binding 0.6733 Informative Inherited
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 0.3644 Informative Inherited
Molecular Function (MF) transferase activity, transferring one-carbon groups 1 Informative Inherited
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 0.01058 Informative Inherited
Molecular Function (MF) signal transducer activity 1 Informative Inherited
Molecular Function (MF) molecular transducer activity 1 Informative Inherited
Molecular Function (MF) enzyme inhibitor activity 0.009785 Informative Inherited
Molecular Function (MF) kinase activity 1 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 1 Informative Inherited
Molecular Function (MF) ion channel activity 0 Highly Informative Direct
Molecular Function (MF) ubiquitin-like protein transferase activity 0.00000003428 Highly Informative Direct
Molecular Function (MF) protein kinase regulator activity 0.0000000001786 Highly Informative Direct
Molecular Function (MF) small GTPase binding 0.0000005976 Highly Informative Direct
Molecular Function (MF) cell adhesion molecule binding 0.0001778 Highly Informative Direct
Molecular Function (MF) glycolipid binding 0.00004576 Highly Informative Direct
Molecular Function (MF) gated channel activity 1 Highly Informative Inherited
Molecular Function (MF) alcohol binding 0.002212 Highly Informative Inherited
Molecular Function (MF) transcription factor binding 0.2931 Highly Informative Inherited
Molecular Function (MF) S-adenosylmethionine-dependent methyltransferase activity 0.707 Highly Informative Inherited
Molecular Function (MF) protein domain specific binding 0.248 Highly Informative Inherited
Molecular Function (MF) transmembrane signaling receptor activity 1 Highly Informative Inherited
Molecular Function (MF) tubulin binding 1 Highly Informative Inherited
Molecular Function (MF) transferase activity, transferring pentosyl groups 0.1431 Highly Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.00001934 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) macromolecular complex 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.544 Least Informative Inherited
Cellular Component (CC) cell projection 0.0000001611 Moderately Informative Direct
Cellular Component (CC) extracellular region part 1 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 0.1802 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.6843 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) intrinsic component of membrane 0.9274 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.5066 Moderately Informative Inherited
Cellular Component (CC) bounding membrane of organelle 0.118 Moderately Informative Inherited
Cellular Component (CC) ribonucleoprotein granule 0.00000000001437 Informative Direct
Cellular Component (CC) neuron projection 0.0006126 Informative Direct
Cellular Component (CC) apical part of cell 0.000002169 Informative Direct
Cellular Component (CC) synapse 0.0000001922 Informative Direct
Cellular Component (CC) plasma membrane region 0.0000000000003834 Informative Direct
Cellular Component (CC) supramolecular polymer 0.00000000000006504 Informative Direct
Cellular Component (CC) cytoplasmic region 0.03735 Informative Inherited
Cellular Component (CC) plasma membrane bounded cell projection part 0.2751 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) nucleoplasm part 0.9623 Informative Inherited
Cellular Component (CC) transporter complex 0.003407 Informative Inherited
Cellular Component (CC) actin cytoskeleton 0.2641 Informative Inherited
Cellular Component (CC) protein-DNA complex 0.1657 Informative Inherited
Cellular Component (CC) chromosome 1 Informative Inherited
Cellular Component (CC) Golgi apparatus 0.01081 Informative Inherited
Cellular Component (CC) myofibril 0.00000000000001496 Highly Informative Direct
Cellular Component (CC) contractile fiber part 0.00000000001279 Highly Informative Direct
Cellular Component (CC) pole plasm 0 Highly Informative Direct
Cellular Component (CC) Golgi subcompartment 0.00008927 Highly Informative Direct
Cellular Component (CC) protein serine/threonine phosphatase complex 0.03454 Highly Informative Inherited
Cellular Component (CC) intrinsic component of plasma membrane 1 Highly Informative Inherited
Cellular Component (CC) transcription elongation factor complex 0.008793 Highly Informative Inherited
Cellular Component (CC) replisome 0.006472 Highly Informative Inherited
Cellular Component (CC) nuclear chromosome part 0.5358 Highly Informative Inherited
Cellular Component (CC) chromatin 0.761 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides0.4016Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds0.1213Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)In linear amides0.000000001232Moderately InformativeDirect
Enzyme Commission (EC)Carboxylic ester hydrolases0.0008122Moderately InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides0.001342Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep1Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases0.3822Moderately InformativeInherited
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase0.000000000000344InformativeDirect
Enzyme Commission (EC)Diacylglycerol kinase0.0000000000002201Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.4115Least InformativeInherited
Disease Ontology (DO)benign neoplasm0.02019Moderately InformativeInherited
Disease Ontology (DO)organ system benign neoplasm0.181InformativeInherited
Disease Ontology (DO)skin hemangioma0.000003967Highly InformativeDirect
Disease Ontology (DO)rhabdomyosarcoma0.0005856Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the integument0.6828Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin morphology0.2827Moderately InformativeInherited
Phenotypic Abnormality (PA)Localized skin lesion0.1177InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.4056Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.5607Least InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.4099Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.5689Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.6249Moderately InformativeInherited
Mammalian Phenotype (MP)embryo phenotype0.7233Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal Peyer's patch morphology0.04948InformativeInherited
Mammalian Phenotype (MP)incomplete somite formation0.0002859Highly InformativeDirect
Mammalian Phenotype (MP)extramedullary hematopoiesis0.0005207Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.01877Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.5112Least InformativeInherited
Worm Phenotype (WP)organism stress response variant0.002073Moderately InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.02569Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.2995Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant1Moderately InformativeInherited
Worm Phenotype (WP)forward locomotion variant0.0002693InformativeDirect
Worm Phenotype (WP)localized movement variant0.0002825InformativeDirect
Worm Phenotype (WP)chemotaxis variant0.0002929InformativeDirect
Worm Phenotype (WP)body posture variant0.0006147InformativeDirect
Worm Phenotype (WP)locomotor coordination variant0.001961InformativeInherited
Worm Phenotype (WP)body width variant0.2286InformativeInherited
Worm Phenotype (WP)odorant negative chemotaxis defective0.00000714Highly InformativeDirect
Worm Phenotype (WP)octanol chemotaxis variant0.00005486Highly InformativeDirect
Worm Phenotype (WP)organism heat response variant0.0003496Highly InformativeDirect
Worm Phenotype (WP)fat0.0005454Highly InformativeDirect
Worm Phenotype (WP)body posture wavelength variant0.4086Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)cell cycle progression0.05887InformativeInherited

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)behavior defective0.000324Moderately InformativeDirect
Fly Phenotype (FP)sensory perception defective0.00000002088InformativeDirect
Fly Phenotype (FP)neurophysiology defective0.00001091InformativeDirect
Fly Phenotype (FP)temperature response defective0.002265Highly InformativeInherited

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)anatomical group0.007859Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.1251Least InformativeInherited
Fly Anatomy (FA)nervous system0.1945Least InformativeInherited
Fly Anatomy (FA)adult0.2441Least InformativeInherited
Fly Anatomy (FA)somatic cell0.4001Least InformativeInherited
Fly Anatomy (FA)integumentary system0.4974Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)sense organ0.05968Moderately InformativeInherited
Fly Anatomy (FA)adult head0.1357Moderately InformativeInherited
Fly Anatomy (FA)tagmatic subdivision of integument0.1621Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.2241Moderately InformativeInherited
Fly Anatomy (FA)neuron0.5122Moderately InformativeInherited
Fly Anatomy (FA)appendage0.5133Moderately InformativeInherited
Fly Anatomy (FA)adult segment0.6172Moderately InformativeInherited
Fly Anatomy (FA)adult external head0.003646InformativeInherited
Fly Anatomy (FA)procephalic segment0.05405InformativeInherited
Fly Anatomy (FA)adult head segment0.05535InformativeInherited
Fly Anatomy (FA)mechanosensory system0.6452InformativeInherited
Fly Anatomy (FA)adult antennal sense organ0.0006311Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)nervous system0.6185Least InformativeInherited
Zebrafish Anatomy (ZA)central nervous system0.4874Moderately InformativeInherited
Zebrafish Anatomy (ZA)anatomical cluster0.8434Moderately InformativeInherited
Zebrafish Anatomy (ZA)cell0.8625Moderately InformativeInherited
Zebrafish Anatomy (ZA)ventricular system0.05614Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.5863Least InformativeInherited
Enzyme Commission (EC)Transferring phosphorus-containing groups1Least InformativeInherited
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds0.0129Moderately InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides0.05734Moderately InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect
Enzyme Commission (EC)In linear amides0.000005017InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase0.000005185InformativeDirect
Enzyme Commission (EC)In phosphorus-containing anhydrides0.0001163InformativeDirect
Enzyme Commission (EC)Carboxylic ester hydrolases0.01109InformativeInherited
Enzyme Commission (EC)Pentosyltransferases0.05088InformativeInherited
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase0.0000000000001459Highly InformativeDirect
Enzyme Commission (EC)Diacylglycerol kinase (ATP)0.00000000002442Highly InformativeDirect
Enzyme Commission (EC)HECT-type E3 ubiquitin transferase0.000001552Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processDifferentiation0Moderately InformativeDirect
Biological processUbl conjugation pathway0Moderately InformativeDirect
Biological processIon transport0.00000002305Moderately InformativeDirect
Biological processApoptosis0.0000001549Moderately InformativeDirect
Biological processHost-virus interaction0.0006714Moderately InformativeDirect
Biological processCell cycle0.03871Moderately InformativeInherited
Biological processMeiosis0InformativeDirect
Biological processAngiogenesis0.0000000943InformativeDirect
Biological processWnt signaling pathway0.000001055InformativeDirect
Biological processMitosis0.0001333InformativeDirect
Biological processPlant defense0.000259InformativeDirect
Biological processCalcium transport0Highly InformativeDirect
Biological processNotch signaling pathway0Highly InformativeDirect
Biological processRNA-mediated gene silencing0Highly InformativeDirect
Biological processInhibition of host NF-kappa-B by virus0Highly InformativeDirect
Biological processSpermatogenesis0.000000000006381Highly InformativeDirect
Biological processExocytosis0.0000004676Highly InformativeDirect
Biological processPotassium transport0.001141Highly InformativeInherited
Cellular componentNucleus0Least InformativeDirect
Cellular componentMembrane0.000000003838Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentGolgi apparatus0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentEndosome0Moderately InformativeDirect
Cellular componentCytoskeleton0.00000000005172Moderately InformativeDirect
Cellular componentChromosome0.000635InformativeDirect
Cellular componentSynapse0.1244InformativeInherited
Cellular componentPostsynaptic cell membrane0.0001723Highly InformativeDirect
Cellular componentCentromere0.0009572Highly InformativeDirect
Coding sequence diversityAlternative splicing0.00001174Least InformativeDirect
DiseaseTumor suppressor0.00004257Moderately InformativeDirect
DomainRepeat0Least InformativeDirect
DomainCoiled coil0.00000000000004061Moderately InformativeDirect
DomainANK repeat0InformativeDirect
DomainSH3 domain0.00000002252InformativeDirect
DomainTPR repeat0.00001045Highly InformativeDirect
Molecular functionCalcium0.00000000001337Moderately InformativeDirect
Molecular functionLipid-binding0.00000111Moderately InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationActivator0.0000000004079Moderately InformativeDirect
Post-translational modificationKinase1Moderately InformativeInherited
Post-translational modificationCalmodulin-binding0InformativeDirect
Post-translational modificationGTPase activation0InformativeDirect
Post-translational modificationIon channel0InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0.00003462InformativeDirect
Post-translational modificationActin-binding0.0004294InformativeDirect
Post-translational modificationToxin1InformativeInherited
Post-translational modificationCalcium channel0Highly InformativeDirect
Post-translational modificationNeurotoxin0.09427Highly InformativeInherited
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationPalmitate0.00001078Moderately InformativeDirect
Post-translational modificationMethylation0.0003008Moderately InformativeDirect
Post-translational modificationHydroxylation0InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR002110 SSF48403 Protein matches
Abstract

The ankyrin repeat is one of the most common protein-protein interaction motifs in nature. Ankyrin repeats are tandemly repeated modules of about 33 amino acids. They occur in a large number of functionally diverse proteins mainly from eukaryotes. The few known examples from prokaryotes and viruses may be the result of horizontal gene transfers [PubMed8108379]. The repeat has been found in proteins of diverse function such as transcriptional initiators, cell-cycle regulators, cytoskeletal, ion transporters and signal transducers. The ankyrin fold appears to be defined by its structure rather than its function since there is no specific sequence or structure which is universally recognised by it.

The conserved fold of the ankyrin repeat unit is known from several crystal and solution structures [PubMed8875926, PubMed9353127, PubMed9461436, PubMed9865693]. Each repeat folds into a helix-loop-helix structure with a beta-hairpin/loop region projecting out from the helices at a 90o angle. The repeats stack together to form an L-shaped structure [PubMed8875926, PubMed12461176].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 19 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Ankyrin repeat domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 19 hidden Markov models representing the Ankyrin repeat superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]