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Ankyrin repeat superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   beta-hairpin-alpha-hairpin repeat [ 74651] (2)
Superfamily:   Ankyrin repeat [ 48403]
Families:   Ankyrin repeat [ 48404] (17)


Superfamily statistics
Genomes (1,789) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 80,489 226,127 42
Proteins 69,282 190,359 42


Functional annotation
General category General
Detailed category Protein interaction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biological regulation0.032560.001065Least InformativeInherited
Biological Process (BP)multicellular organismal process0.39260.0000000002666Least InformativeInherited
Biological Process (BP)response to stimulus11Least InformativeInherited
Biological Process (BP)single-organism cellular process10.7291Least InformativeInherited
Biological Process (BP)negative regulation of cellular process0.00001520.000221Moderately InformativeDirect
Biological Process (BP)regulation of developmental process0.2840.03739Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.25210.001308Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.022420.005343Moderately InformativeInherited
Biological Process (BP)regulation of localization0.82280.04459Moderately InformativeInherited
Biological Process (BP)regulation of cell communication0.084960.0000002143Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.14940.08114Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.86891Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process0.321Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.61980.02739Moderately InformativeInherited
Biological Process (BP)regulation of response to stimulus0.044820.005213Moderately InformativeInherited
Biological Process (BP)regulation of signaling0.055410.000000005109Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process0.00069011Moderately InformativeInherited
Biological Process (BP)regulation of macromolecule biosynthetic process0.042170.8937Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.079850.8662Moderately InformativeInherited
Biological Process (BP)immune system process0.37671Moderately InformativeInherited
Biological Process (BP)cell differentiation0.94331Moderately InformativeInherited
Biological Process (BP)animal organ development0.007851Moderately InformativeInherited
Biological Process (BP)cell communication0.084481Moderately InformativeInherited
Biological Process (BP)single organism signaling0.55981Moderately InformativeInherited
Biological Process (BP)regulation of molecular function0.000000031740.002424Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.0052460.0173Moderately InformativeInherited
Biological Process (BP)cell cycle process0.00001710.00000000001413InformativeDirect
Biological Process (BP)regulation of protein modification process0.00000012440.0000003155InformativeDirect
Biological Process (BP)regulation of anatomical structure morphogenesis0.48220.08763InformativeInherited
Biological Process (BP)negative regulation of transport0.22180.1839InformativeInherited
Biological Process (BP)regulation of transferase activity0.000071460.03182InformativeInherited
Biological Process (BP)regulation of growth0.00030710.06268InformativeInherited
Biological Process (BP)negative regulation of molecular function0.18530.4462InformativeInherited
Biological Process (BP)regulation of peptide transport0.10580.8438InformativeInherited
Biological Process (BP)regulation of cellular localization0.012830.00008262InformativeInherited
Biological Process (BP)regulation of protein localization0.036460.05096InformativeInherited
Biological Process (BP)regulation of intracellular signal transduction0.76751InformativeInherited
Biological Process (BP)regulation of phosphorylation0.16560.3785InformativeInherited
Biological Process (BP)positive regulation of signal transduction0.29040.509InformativeInherited
Biological Process (BP)hemopoiesis0.86840.7797InformativeInherited
Biological Process (BP)cell surface receptor signaling pathway0.21010.07071InformativeInherited
Biological Process (BP)regulation of cell cycle0.0000000009310.04449InformativeInherited
Biological Process (BP)negative regulation of intracellular transport0.000088870.000143Highly InformativeDirect
Biological Process (BP)negative regulation of sequence-specific DNA binding transcription factor activity0.00018310.0009717Highly InformativeDirect
Biological Process (BP)positive regulation of growth0.000055650.00001061Highly InformativeDirect
Biological Process (BP)maintenance of location0.0000033660.0000002788Highly InformativeDirect
Biological Process (BP)regulation of protein import0.000098250.0008142Highly InformativeDirect
Biological Process (BP)regulation of cellular response to growth factor stimulus0.0000018690.7585Highly InformativeInherited
Biological Process (BP)negative regulation of establishment of protein localization0.024850.005963Highly InformativeInherited
Biological Process (BP)regulation of protein localization to nucleus0.00015690.4339Highly InformativeInherited
Biological Process (BP)regulation of intracellular protein transport0.0029850.0002685Highly InformativeInherited
Biological Process (BP)regulation of nucleocytoplasmic transport0.000020560.03764Highly InformativeInherited
Biological Process (BP)negative regulation of phosphate metabolic process00.001599Highly InformativeInherited
Biological Process (BP)regulation of protein modification by small protein conjugation or removal0.06390.02162Highly InformativeInherited
Biological Process (BP)regulation of transmembrane receptor protein serine/threonine kinase signaling pathway0.00000053250.9911Highly InformativeInherited
Biological Process (BP)myeloid cell differentiation0.000096490.7372Highly InformativeInherited
Molecular Function (MF)binding10.567Least InformativeInherited
Molecular Function (MF)molecular function regulator0.0029640.0149Moderately InformativeInherited
Molecular Function (MF)enzyme binding0.000000013450.0000008467InformativeDirect
Molecular Function (MF)enzyme inhibitor activity0.00000018430.01054InformativeInherited
Molecular Function (MF)kinase regulator activity0.000000000000014440.00001226Highly InformativeDirect
Molecular Function (MF)transcription factor binding0.015970.4485Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0.0000000002666 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.0000001136 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.7291 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) biological regulation 0.001065 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) ion transport 0.0000004931 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 0.000001155 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.00000001173 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 0.0000002143 Moderately Informative Direct
Biological Process (BP) regulation of signaling 0.000000005109 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.000221 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.0006062 Moderately Informative Direct
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.3756 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.9705 Moderately Informative Inherited
Biological Process (BP) single-organism transport 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.08114 Moderately Informative Inherited
Biological Process (BP) response to biotic stimulus 0.4847 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.891 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.1389 Moderately Informative Inherited
Biological Process (BP) single organism signaling 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.3867 Moderately Informative Inherited
Biological Process (BP) animal organ development 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.02739 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) protein complex biogenesis 0.8807 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.226 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.005343 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.001308 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.8662 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.04459 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.0173 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.8021 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.002424 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.8937 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.005213 Moderately Informative Inherited
Biological Process (BP) reproduction 0.2273 Moderately Informative Inherited
Biological Process (BP) immune system process 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.07956 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.2829 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.03739 Moderately Informative Inherited
Biological Process (BP) tissue development 0.4135 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) nitrogen compound transport 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.06044 Moderately Informative Inherited
Biological Process (BP) system process 0.000000000004285 Informative Direct
Biological Process (BP) microtubule-based process 0.0004384 Informative Direct
Biological Process (BP) behavior 0.0000000000007899 Informative Direct
Biological Process (BP) glutamine family amino acid metabolic process 0.0009677 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.0002476 Informative Direct
Biological Process (BP) cell cycle process 0.00000000001413 Informative Direct
Biological Process (BP) negative regulation of signaling 0.00005462 Informative Direct
Biological Process (BP) metal ion transport 0.00000001549 Informative Direct
Biological Process (BP) regulation of protein modification process 0.0000003155 Informative Direct
Biological Process (BP) cellular component morphogenesis 0 Informative Direct
Biological Process (BP) growth 0.00001783 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.0000001097 Informative Direct
Biological Process (BP) multi-organism reproductive process 0.000003078 Informative Direct
Biological Process (BP) cell development 0.0005922 Informative Direct
Biological Process (BP) regulation of nervous system development 0.00000008166 Informative Direct
Biological Process (BP) transmembrane transport 0.0001815 Informative Direct
Biological Process (BP) regulation of cellular localization 0.00008262 Informative Direct
Biological Process (BP) negative regulation of transport 0.1839 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.01277 Informative Inherited
Biological Process (BP) regulation of system process 0.9126 Informative Inherited
Biological Process (BP) cation homeostasis 0.0286 Informative Inherited
Biological Process (BP) organelle assembly 0.5297 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.7951 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.1092 Informative Inherited
Biological Process (BP) response to nitrogen compound 1 Informative Inherited
Biological Process (BP) cellular response to lipid 0.1714 Informative Inherited
Biological Process (BP) response to bacterium 0.01373 Informative Inherited
Biological Process (BP) positive regulation of gene expression 0.1445 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 0.07071 Informative Inherited
Biological Process (BP) regulation of transferase activity 0.03182 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 0.8812 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 1 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 1 Informative Inherited
Biological Process (BP) circulatory system development 0.2723 Informative Inherited
Biological Process (BP) inorganic ion homeostasis 0.06136 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.2458 Informative Inherited
Biological Process (BP) response to metal ion 0.8952 Informative Inherited
Biological Process (BP) protein oligomerization 0.08617 Informative Inherited
Biological Process (BP) actin cytoskeleton organization 0.5952 Informative Inherited
Biological Process (BP) supramolecular fiber organization 0.002115 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.08763 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.3408 Informative Inherited
Biological Process (BP) post-embryonic development 0.4847 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) regulation of growth 0.06268 Informative Inherited
Biological Process (BP) regulation of cell differentiation 0.02808 Informative Inherited
Biological Process (BP) negative regulation of molecular function 0.4462 Informative Inherited
Biological Process (BP) regulation of ion transport 0.4771 Informative Inherited
Biological Process (BP) positive regulation of transport 0.5932 Informative Inherited
Biological Process (BP) regulation of peptide transport 0.8438 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 1 Informative Inherited
Biological Process (BP) regulation of protein localization 0.05096 Informative Inherited
Biological Process (BP) locomotion 0.9262 Informative Inherited
Biological Process (BP) regulation of phosphorylation 0.3785 Informative Inherited
Biological Process (BP) response to wounding 0.46 Informative Inherited
Biological Process (BP) negative regulation of macromolecule biosynthetic process 0.7181 Informative Inherited
Biological Process (BP) negative regulation of cellular biosynthetic process 0.9608 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.1516 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 1 Informative Inherited
Biological Process (BP) generation of neurons 0.01435 Informative Inherited
Biological Process (BP) response to temperature stimulus 0.001744 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.5831 Informative Inherited
Biological Process (BP) regulation of defense response 0.3775 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.1952 Informative Inherited
Biological Process (BP) regulation of cytokine production 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.003117 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.1022 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.4228 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.509 Informative Inherited
Biological Process (BP) hemopoiesis 0.7797 Informative Inherited
Biological Process (BP) regulation of transmembrane transport 0.1469 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.3516 Informative Inherited
Biological Process (BP) central nervous system development 1 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 1 Informative Inherited
Biological Process (BP) response to acid chemical 0.2458 Informative Inherited
Biological Process (BP) epithelium development 0.007484 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.4164 Informative Inherited
Biological Process (BP) movement of cell or subcellular component 1 Informative Inherited
Biological Process (BP) localization of cell 1 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.01295 Informative Inherited
Biological Process (BP) single organism reproductive process 0.001475 Informative Inherited
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 0.241 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.3472 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.4211 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.7904 Informative Inherited
Biological Process (BP) DNA metabolic process 0.01563 Informative Inherited
Biological Process (BP) embryo development 0.5841 Informative Inherited
Biological Process (BP) mitotic cell cycle 1 Informative Inherited
Biological Process (BP) regulation of cell cycle 0.04449 Informative Inherited
Biological Process (BP) protein transport 0.8169 Informative Inherited
Biological Process (BP) protein localization to organelle 0.4573 Informative Inherited
Biological Process (BP) intracellular transport 1 Informative Inherited
Biological Process (BP) single-organism cellular localization 0.6704 Informative Inherited
Biological Process (BP) nuclear division 0.00000000008429 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 0.0000003413 Highly Informative Direct
Biological Process (BP) protein lipidation 0.00000004022 Highly Informative Direct
Biological Process (BP) response to heat 0.0001177 Highly Informative Direct
Biological Process (BP) response to mechanical stimulus 0.000000009419 Highly Informative Direct
Biological Process (BP) cellular component assembly involved in morphogenesis 0.000000005139 Highly Informative Direct
Biological Process (BP) cell growth 0.00000000001808 Highly Informative Direct
Biological Process (BP) regulation of transmembrane transporter activity 0.00034 Highly Informative Direct
Biological Process (BP) epithelial cell differentiation 0.0000001101 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular transport 0.000143 Highly Informative Direct
Biological Process (BP) positive regulation of transporter activity 0.00003637 Highly Informative Direct
Biological Process (BP) protein modification by small protein conjugation 0.0009168 Highly Informative Direct
Biological Process (BP) regulation of intracellular protein transport 0.0002685 Highly Informative Direct
Biological Process (BP) regulation of membrane potential 0.000348 Highly Informative Direct
Biological Process (BP) regulation of circadian rhythm 0.00006089 Highly Informative Direct
Biological Process (BP) positive regulation of ion transport 0.0001381 Highly Informative Direct
Biological Process (BP) macromolecule methylation 0.000000000002257 Highly Informative Direct
Biological Process (BP) negative regulation of sequence-specific DNA binding transcription factor activity 0.0009717 Highly Informative Direct
Biological Process (BP) post-translational protein modification 0.000000000317 Highly Informative Direct
Biological Process (BP) single-organism behavior 0 Highly Informative Direct
Biological Process (BP) DNA methylation or demethylation 0 Highly Informative Direct
Biological Process (BP) positive regulation of growth 0.00001061 Highly Informative Direct
Biological Process (BP) neuron development 0.0001203 Highly Informative Direct
Biological Process (BP) nervous system process 0.0001563 Highly Informative Direct
Biological Process (BP) maintenance of location 0.0000002788 Highly Informative Direct
Biological Process (BP) meiotic cell cycle 0.0000003784 Highly Informative Direct
Biological Process (BP) positive regulation of nervous system development 0.000004542 Highly Informative Direct
Biological Process (BP) developmental growth involved in morphogenesis 0.0000001394 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0.0008768 Highly Informative Direct
Biological Process (BP) divalent inorganic cation transport 0 Highly Informative Direct
Biological Process (BP) import into cell 0.000000002037 Highly Informative Direct
Biological Process (BP) inorganic cation transmembrane transport 0.0000000002876 Highly Informative Direct
Biological Process (BP) plasma membrane bounded cell projection organization 0 Highly Informative Direct
Biological Process (BP) regulation of protein import 0.0008142 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.6927 Highly Informative Inherited
Biological Process (BP) negative regulation of nervous system development 0.2695 Highly Informative Inherited
Biological Process (BP) response to growth factor 0.5569 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.7585 Highly Informative Inherited
Biological Process (BP) cellular calcium ion homeostasis 0.02873 Highly Informative Inherited
Biological Process (BP) regulation of hemopoiesis 0.04771 Highly Informative Inherited
Biological Process (BP) mitotic cell cycle phase transition 0.001887 Highly Informative Inherited
Biological Process (BP) cellular response to abiotic stimulus 0.01386 Highly Informative Inherited
Biological Process (BP) response to purine-containing compound 0.1028 Highly Informative Inherited
Biological Process (BP) cellular response to organonitrogen compound 0.9686 Highly Informative Inherited
Biological Process (BP) response to molecule of bacterial origin 0.02557 Highly Informative Inherited
Biological Process (BP) anatomical structure homeostasis 0.00887 Highly Informative Inherited
Biological Process (BP) positive regulation of transcription from RNA polymerase II promoter 0.2314 Highly Informative Inherited
Biological Process (BP) response to hypoxia 0.3574 Highly Informative Inherited
Biological Process (BP) cellular response to decreased oxygen levels 0.001545 Highly Informative Inherited
Biological Process (BP) heart development 0.7917 Highly Informative Inherited
Biological Process (BP) tube morphogenesis 0.01145 Highly Informative Inherited
Biological Process (BP) cell proliferation 0.8118 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular component biogenesis 0.005844 Highly Informative Inherited
Biological Process (BP) actin filament organization 0.2295 Highly Informative Inherited
Biological Process (BP) negative regulation of cell development 0.05143 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.6948 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 1 Highly Informative Inherited
Biological Process (BP) appendage development 0.001967 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.03077 Highly Informative Inherited
Biological Process (BP) female gamete generation 1 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 0.1847 Highly Informative Inherited
Biological Process (BP) negative regulation of establishment of protein localization 0.005963 Highly Informative Inherited
Biological Process (BP) regulation of protein localization to nucleus 0.4339 Highly Informative Inherited
Biological Process (BP) regulation of nucleocytoplasmic transport 0.03764 Highly Informative Inherited
Biological Process (BP) negative regulation of phosphate metabolic process 0.001599 Highly Informative Inherited
Biological Process (BP) regeneration 0.02041 Highly Informative Inherited
Biological Process (BP) wound healing 0.05131 Highly Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter in response to stress 0.004449 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.5105 Highly Informative Inherited
Biological Process (BP) regulation of toll-like receptor signaling pathway 0.03532 Highly Informative Inherited
Biological Process (BP) response to organophosphorus 0.101 Highly Informative Inherited
Biological Process (BP) negative regulation of cytokine production 0.3756 Highly Informative Inherited
Biological Process (BP) negative regulation of cytoskeleton organization 0.1168 Highly Informative Inherited
Biological Process (BP) negative regulation of supramolecular fiber organization 0.1016 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 0.03812 Highly Informative Inherited
Biological Process (BP) negative regulation of multi-organism process 0.4501 Highly Informative Inherited
Biological Process (BP) regulation of protein modification by small protein conjugation or removal 0.02162 Highly Informative Inherited
Biological Process (BP) DNA replication 0.8892 Highly Informative Inherited
Biological Process (BP) regulation of microtubule-based process 0.08984 Highly Informative Inherited
Biological Process (BP) regulation of chromosome organization 0.4983 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.9911 Highly Informative Inherited
Biological Process (BP) myeloid cell differentiation 0.7372 Highly Informative Inherited
Biological Process (BP) regulation of G-protein coupled receptor protein signaling pathway 0.004318 Highly Informative Inherited
Biological Process (BP) post-embryonic animal morphogenesis 0.006727 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.64 Highly Informative Inherited
Biological Process (BP) germ cell development 0.5389 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular signal transduction 0.06918 Highly Informative Inherited
Biological Process (BP) response to osmotic stress 0.03176 Highly Informative Inherited
Biological Process (BP) regulation of cell size 0.2471 Highly Informative Inherited
Biological Process (BP) glycoprotein metabolic process 1 Highly Informative Inherited
Biological Process (BP) macromolecule glycosylation 0.9166 Highly Informative Inherited
Biological Process (BP) protein import 0.3532 Highly Informative Inherited
Biological Process (BP) protein localization to nucleus 0.9357 Highly Informative Inherited
Biological Process (BP) single-organism nuclear import 0.2516 Highly Informative Inherited
Molecular Function (MF) binding 0.567 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) structural molecule activity 0.0007942 Moderately Informative Direct
Molecular Function (MF) small molecule binding 1 Moderately Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 1 Moderately Informative Inherited
Molecular Function (MF) transporter activity 0.005642 Moderately Informative Inherited
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) molecular function regulator 0.0149 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) phospholipid binding 0.00005759 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0.0000000000002457 Informative Direct
Molecular Function (MF) enzyme binding 0.0000008467 Informative Direct
Molecular Function (MF) passive transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) amide binding 0.796 Informative Inherited
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring one-carbon groups 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 0.4539 Informative Inherited
Molecular Function (MF) molecular transducer activity 1 Informative Inherited
Molecular Function (MF) signal transducer activity 1 Informative Inherited
Molecular Function (MF) enzyme inhibitor activity 0.01054 Informative Inherited
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 0.003335 Informative Inherited
Molecular Function (MF) kinase activity 1 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 1 Informative Inherited
Molecular Function (MF) transcription factor activity, sequence-specific DNA binding 1 Informative Inherited
Molecular Function (MF) ion channel activity 0 Highly Informative Direct
Molecular Function (MF) kinase regulator activity 0.00001226 Highly Informative Direct
Molecular Function (MF) ubiquitin-like protein transferase activity 0.00000003299 Highly Informative Direct
Molecular Function (MF) small GTPase binding 0.00000008944 Highly Informative Direct
Molecular Function (MF) cell adhesion molecule binding 0.0006914 Highly Informative Direct
Molecular Function (MF) glycolipid binding 0.00004965 Highly Informative Direct
Molecular Function (MF) alcohol binding 0.002397 Highly Informative Inherited
Molecular Function (MF) transcription factor binding 0.4485 Highly Informative Inherited
Molecular Function (MF) S-adenosylmethionine-dependent methyltransferase activity 0.7434 Highly Informative Inherited
Molecular Function (MF) protein domain specific binding 0.3657 Highly Informative Inherited
Molecular Function (MF) transmembrane signaling receptor activity 1 Highly Informative Inherited
Molecular Function (MF) gated channel activity 1 Highly Informative Inherited
Molecular Function (MF) tubulin binding 1 Highly Informative Inherited
Molecular Function (MF) transferase activity, transferring pentosyl groups 0.1567 Highly Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.000008392 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.7192 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cell projection 0.000000009474 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.3992 Moderately Informative Inherited
Cellular Component (CC) whole membrane 0.268 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 0.2895 Moderately Informative Inherited
Cellular Component (CC) intrinsic component of membrane 0.9596 Moderately Informative Inherited
Cellular Component (CC) extracellular region part 1 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 0.5101 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.5181 Moderately Informative Inherited
Cellular Component (CC) bounding membrane of organelle 0.0988 Moderately Informative Inherited
Cellular Component (CC) ribonucleoprotein granule 0.00000000002379 Informative Direct
Cellular Component (CC) neuron projection 0.00003041 Informative Direct
Cellular Component (CC) apical part of cell 0.000007594 Informative Direct
Cellular Component (CC) membrane region 0.0002329 Informative Direct
Cellular Component (CC) plasma membrane region 0.000000000002983 Informative Direct
Cellular Component (CC) supramolecular polymer 0.00000000000002005 Informative Direct
Cellular Component (CC) transporter complex 0.0005996 Informative Direct
Cellular Component (CC) Golgi apparatus 0.01516 Informative Inherited
Cellular Component (CC) cytoplasmic region 0.06984 Informative Inherited
Cellular Component (CC) plasma membrane bounded cell projection part 0.2566 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) nucleoplasm part 1 Informative Inherited
Cellular Component (CC) actin cytoskeleton 0.7613 Informative Inherited
Cellular Component (CC) chromosome 1 Informative Inherited
Cellular Component (CC) protein-DNA complex 0.2163 Informative Inherited
Cellular Component (CC) sarcomere 0.0002216 Highly Informative Direct
Cellular Component (CC) pole plasm 0 Highly Informative Direct
Cellular Component (CC) Golgi subcompartment 0.00001844 Highly Informative Direct
Cellular Component (CC) protein serine/threonine phosphatase complex 0.04096 Highly Informative Inherited
Cellular Component (CC) intrinsic component of plasma membrane 1 Highly Informative Inherited
Cellular Component (CC) presynapse 0.04468 Highly Informative Inherited
Cellular Component (CC) transcription elongation factor complex 0.009959 Highly Informative Inherited
Cellular Component (CC) RNA polymerase II transcription factor complex 0.0466 Highly Informative Inherited
Cellular Component (CC) cell-substrate adherens junction 1 Highly Informative Inherited
Cellular Component (CC) replisome 0.007093 Highly Informative Inherited
Cellular Component (CC) nuclear chromosome part 0.606 Highly Informative Inherited
Cellular Component (CC) chromatin 0.715 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides0.4016Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds0.1213Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)In linear amides0.000000001232Moderately InformativeDirect
Enzyme Commission (EC)Carboxylic ester hydrolases0.0008122Moderately InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides0.001342Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep1Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases0.3822Moderately InformativeInherited
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase0.000000000000344InformativeDirect
Enzyme Commission (EC)Diacylglycerol kinase0.0000000000002201Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processDifferentiation0Moderately InformativeDirect
Biological processUbl conjugation pathway0Moderately InformativeDirect
Biological processIon transport0.00000002407Moderately InformativeDirect
Biological processApoptosis0.0000001591Moderately InformativeDirect
Biological processHost-virus interaction0.0006633Moderately InformativeDirect
Biological processCell cycle0.03999Moderately InformativeInherited
Biological processMeiosis0InformativeDirect
Biological processAngiogenesis0.000000102InformativeDirect
Biological processWnt signaling pathway0.000001058InformativeDirect
Biological processMitosis0.0001752InformativeDirect
Biological processPlant defense0.0004034InformativeDirect
Biological processCalcium transport0Highly InformativeDirect
Biological processNotch signaling pathway0Highly InformativeDirect
Biological processRNA-mediated gene silencing0Highly InformativeDirect
Biological processInhibition of host NF-kappa-B by virus0Highly InformativeDirect
Biological processSpermatogenesis0.000000000006118Highly InformativeDirect
Biological processExocytosis0.00000004319Highly InformativeDirect
Biological processPotassium transport0.001128Highly InformativeInherited
Cellular componentNucleus0Least InformativeDirect
Cellular componentMembrane0.000000002936Least InformativeDirect
Cellular componentCytoplasm0.9553Least InformativeInherited
Cellular componentGolgi apparatus0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentEndosome0Moderately InformativeDirect
Cellular componentCytoskeleton0.00000000005887Moderately InformativeDirect
Cellular componentChromosome0.0006511InformativeDirect
Cellular componentSynapse0.1222InformativeInherited
Cellular componentPostsynaptic cell membrane0.0001629Highly InformativeDirect
Cellular componentCentromere0.0009772Highly InformativeDirect
Coding sequence diversityAlternative splicing0.000006609Least InformativeDirect
DiseaseTumor suppressor0.00003991Moderately InformativeDirect
DomainRepeat0Least InformativeDirect
DomainCoiled coil0.00000000000006752Moderately InformativeDirect
DomainANK repeat0InformativeDirect
DomainSH3 domain0.000000006527InformativeDirect
DomainTPR repeat0.00001055Highly InformativeDirect
Molecular functionCalcium0.00000000001568Moderately InformativeDirect
Molecular functionLipid-binding0.000001184Moderately InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationActivator0.0000000004302Moderately InformativeDirect
Post-translational modificationKinase1Moderately InformativeInherited
Post-translational modificationCalmodulin-binding0InformativeDirect
Post-translational modificationGTPase activation0InformativeDirect
Post-translational modificationIon channel0InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0.00003659InformativeDirect
Post-translational modificationActin-binding0.0004306InformativeDirect
Post-translational modificationToxin1InformativeInherited
Post-translational modificationCalcium channel0Highly InformativeDirect
Post-translational modificationNeurotoxin0.05139Highly InformativeInherited
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationPalmitate0.00001177Moderately InformativeDirect
Post-translational modificationMethylation0.0002851Moderately InformativeDirect
Post-translational modificationHydroxylation0InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR002110 SSF48403 Protein matches
Abstract

The ankyrin repeat is one of the most common protein-protein interaction motifs in nature. Ankyrin repeats are tandemly repeated modules of about 33 amino acids. They occur in a large number of functionally diverse proteins mainly from eukaryotes. The few known examples from prokaryotes and viruses may be the result of horizontal gene transfers [PubMed8108379]. The repeat has been found in proteins of diverse function such as transcriptional initiators, cell-cycle regulators, cytoskeletal, ion transporters and signal transducers. The ankyrin fold appears to be defined by its structure rather than its function since there is no specific sequence or structure which is universally recognised by it.

The conserved fold of the ankyrin repeat unit is known from several crystal and solution structures [PubMed8875926, PubMed9353127, PubMed9461436, PubMed9865693]. Each repeat folds into a helix-loop-helix structure with a beta-hairpin/loop region projecting out from the helices at a 90o angle. The repeats stack together to form an L-shaped structure [PubMed8875926, PubMed12461176].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 19 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Ankyrin repeat domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 19 hidden Markov models representing the Ankyrin repeat superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]