SUPERFAMILY 1.75 HMM library and genome assignments server


Ankyrin repeat superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   beta-hairpin-alpha-hairpin repeat [ 74651] (2)
Superfamily:   Ankyrin repeat [ 48403]
Families:   Ankyrin repeat [ 48404] (17)


Superfamily statistics
Genomes (1,447) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 68,299 73,003 42
Proteins 58,777 62,198 42


Functional annotation
General category General
Detailed category Protein interaction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism cellular process0.35150.03306Least InformativeInherited
Biological Process (BP)developmental process0.0017180.0001372Least InformativeInherited
Biological Process (BP)regulation of cellular process0.035881Least InformativeInherited
Biological Process (BP)multicellular organismal process0.0046716.645e-08Least InformativeInherited
Biological Process (BP)localization10.3839Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.00033740.2567Least InformativeInherited
Biological Process (BP)single-organism developmental process0.00055471.738e-08Moderately InformativeDirect
Biological Process (BP)negative regulation of cellular process0.00023340.0007161Moderately InformativeDirect
Biological Process (BP)regulation of molecular function2.931e-070.0004593Moderately InformativeDirect
Biological Process (BP)regulation of localization0.73930.0002306Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.47350.9918Moderately InformativeInherited
Biological Process (BP)immune system process0.023140.1661Moderately InformativeInherited
Biological Process (BP)organ development0.47030.5053Moderately InformativeInherited
Biological Process (BP)cellular localization0.35110.1013Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.38910.00529Moderately InformativeInherited
Biological Process (BP)regulation of cell communication0.10462.408e-05Moderately InformativeInherited
Biological Process (BP)regulation of signaling0.053260.0004426Moderately InformativeInherited
Biological Process (BP)regulation of response to stimulus0.13560.005769Moderately InformativeInherited
Biological Process (BP)regulation of biosynthetic process0.018021Moderately InformativeInherited
Biological Process (BP)regulation of nitrogen compound metabolic process0.005511Moderately InformativeInherited
Biological Process (BP)regulation of cellular metabolic process3.496e-071Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.0057130.1235Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.019560.5023Moderately InformativeInherited
Biological Process (BP)cell cycle process1.067e-064.705e-10InformativeDirect
Biological Process (BP)regulation of protein localization0.0067450.0197InformativeInherited
Biological Process (BP)regulation of intracellular transport0.0011350.0003277InformativeInherited
Biological Process (BP)hematopoietic or lymphoid organ development2.752e-050.02599InformativeInherited
Biological Process (BP)regulation of intracellular protein kinase cascade0.50441InformativeInherited
Biological Process (BP)negative regulation of cell communication0.10780.009744InformativeInherited
Biological Process (BP)negative regulation of signaling0.058160.002325InformativeInherited
Biological Process (BP)negative regulation of response to stimulus0.29780.04292InformativeInherited
Biological Process (BP)negative regulation of molecular function0.47370.5883InformativeInherited
Biological Process (BP)positive regulation of signal transduction0.43430.7652InformativeInherited
Biological Process (BP)regulation of protein phosphorylation1.358e-081InformativeInherited
Biological Process (BP)regulation of kinase activity1.423e-100.8277InformativeInherited
Biological Process (BP)negative regulation of intracellular transport0.00026128.31e-06Highly InformativeDirect
Biological Process (BP)negative regulation of cell cycle4.11e-070.0005677Highly InformativeDirect
Biological Process (BP)negative regulation of protein transport0.00031910.0002038Highly InformativeDirect
Biological Process (BP)maintenance of location6.744e-063.802e-12Highly InformativeDirect
Biological Process (BP)regulation of protein localization to nucleus0.00095580.000161Highly InformativeDirect
Biological Process (BP)regulation of intracellular protein transport0.011034.257e-05Highly InformativeInherited
Biological Process (BP)positive regulation of sequence-specific DNA binding transcription factor activity0.00059440.1085Highly InformativeInherited
Biological Process (BP)mitotic cell cycle0.0051920.8082Highly InformativeInherited
Biological Process (BP)cell cycle phase transition3.164e-060.004464Highly InformativeInherited
Biological Process (BP)negative regulation of signal transduction0.050690.7321Highly InformativeInherited
Biological Process (BP)regulation of nucleocytoplasmic transport3.489e-050.04237Highly InformativeInherited
Biological Process (BP)negative regulation of sequence-specific DNA binding transcription factor activity0.0096090.003162Highly InformativeInherited
Biological Process (BP)regulation of cellular response to growth factor stimulus1.13e-060.58Highly InformativeInherited
Molecular Function (MF)binding0.66150.8394Least InformativeInherited
Molecular Function (MF)enzyme regulator activity0.00011430.0002698Moderately InformativeDirect
Molecular Function (MF)protein binding0.010951.003e-09Moderately InformativeInherited
Molecular Function (MF)enzyme inhibitor activity0.00052466.274e-05InformativeDirect
Molecular Function (MF)enzyme binding3.867e-118.803e-10InformativeDirect
Molecular Function (MF)protein kinase regulator activity01.091e-10Highly InformativeDirect
Molecular Function (MF)transcription factor binding1.824e-050.03853Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 6.645e-08 Least Informative Direct
Biological Process (BP) developmental process 0.0001372 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.3979 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.2567 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 0.3839 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.03306 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) ion transport 3.406e-10 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 0.0002305 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 2.408e-05 Moderately Informative Direct
Biological Process (BP) regulation of signaling 0.0004426 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.0002306 Moderately Informative Direct
Biological Process (BP) homeostatic process 0.0004436 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 1.738e-08 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.0007161 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 0.0004593 Moderately Informative Direct
Biological Process (BP) organic substance transport 0.8557 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.8299 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.5023 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.9372 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.2897 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.9649 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.1235 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.1661 Moderately Informative Inherited
Biological Process (BP) system process 0.08771 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.4316 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.4655 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.9311 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.6118 Moderately Informative Inherited
Biological Process (BP) tissue development 0.1604 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.002528 Moderately Informative Inherited
Biological Process (BP) reproduction 0.003037 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.1013 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.00529 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.005769 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.9637 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cofactor metabolic process 0.9508 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.9918 Moderately Informative Inherited
Biological Process (BP) organ development 0.5053 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.9882 Moderately Informative Inherited
Biological Process (BP) sexual reproduction 1.35e-05 Informative Direct
Biological Process (BP) cell cycle process 4.705e-10 Informative Direct
Biological Process (BP) cell projection organization 7.762e-07 Informative Direct
Biological Process (BP) regulation of intracellular transport 0.0003277 Informative Direct
Biological Process (BP) cellular component morphogenesis 4.018e-05 Informative Direct
Biological Process (BP) single organism reproductive process 1.742e-09 Informative Direct
Biological Process (BP) multicellular organismal reproductive process 4.666e-05 Informative Direct
Biological Process (BP) cellular process involved in reproduction 1.462e-08 Informative Direct
Biological Process (BP) muscle tissue development 0.0001092 Informative Direct
Biological Process (BP) muscle structure development 0.0009218 Informative Direct
Biological Process (BP) regulation of ion transport 0.628 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.5467 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.5577 Informative Inherited
Biological Process (BP) regulation of protein localization 0.0197 Informative Inherited
Biological Process (BP) cellular membrane organization 0.04144 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.3093 Informative Inherited
Biological Process (BP) protein transport 0.03302 Informative Inherited
Biological Process (BP) secretion 0.007771 Informative Inherited
Biological Process (BP) cellular cation homeostasis 0.9507 Informative Inherited
Biological Process (BP) tube development 0.07791 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.5078 Informative Inherited
Biological Process (BP) positive regulation of gene expression 0.816 Informative Inherited
Biological Process (BP) single-organism behavior 0.5132 Informative Inherited
Biological Process (BP) response to other organism 0.1244 Informative Inherited
Biological Process (BP) response to lipid 0.315 Informative Inherited
Biological Process (BP) metal ion transport 0.1278 Informative Inherited
Biological Process (BP) transmembrane transport 0.002237 Informative Inherited
Biological Process (BP) anatomical structure homeostasis 0.1062 Informative Inherited
Biological Process (BP) chromosome organization 1 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.2743 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.01464 Informative Inherited
Biological Process (BP) actin filament-based process 0.7618 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.009744 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.002325 Informative Inherited
Biological Process (BP) regulation of system process 0.4906 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.02599 Informative Inherited
Biological Process (BP) reproductive system development 1 Informative Inherited
Biological Process (BP) positive regulation of developmental process 1 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.02562 Informative Inherited
Biological Process (BP) regulation of cell development 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.7933 Informative Inherited
Biological Process (BP) generation of neurons 0.1254 Informative Inherited
Biological Process (BP) DNA metabolic process 0.001774 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 1 Informative Inherited
Biological Process (BP) proteolysis 1 Informative Inherited
Biological Process (BP) protein catabolic process 0.5111 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 0.9774 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.04433 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.09034 Informative Inherited
Biological Process (BP) negative regulation of cellular metabolic process 0.5007 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.5985 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.02815 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.6393 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0.6113 Informative Inherited
Biological Process (BP) epithelium development 0.6995 Informative Inherited
Biological Process (BP) regulation of response to stress 0.3104 Informative Inherited
Biological Process (BP) positive regulation of immune system process 1 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) tetrapyrrole metabolic process 0.001213 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 1 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 1 Informative Inherited
Biological Process (BP) protein modification by small protein conjugation or removal 0.03385 Informative Inherited
Biological Process (BP) positive regulation of transport 0.009132 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.1487 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.1197 Informative Inherited
Biological Process (BP) negative regulation of molecular function 0.5883 Informative Inherited
Biological Process (BP) response to DNA damage stimulus 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.3908 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.7652 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.7023 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 1 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.7829 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.4272 Informative Inherited
Biological Process (BP) growth 0.003672 Informative Inherited
Biological Process (BP) regulation of locomotion 1 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.7627 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.7079 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.2269 Informative Inherited
Biological Process (BP) response to external stimulus 0.198 Informative Inherited
Biological Process (BP) sensory organ development 1 Informative Inherited
Biological Process (BP) multi-organism reproductive process 1 Informative Inherited
Biological Process (BP) organ morphogenesis 0.7516 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) locomotion 0.7143 Informative Inherited
Biological Process (BP) cellular component movement 1 Informative Inherited
Biological Process (BP) localization of cell 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.04292 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.3464 Informative Inherited
Biological Process (BP) metal ion homeostasis 0.004638 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 1 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 1 Informative Inherited
Biological Process (BP) glutamine family amino acid metabolic process 0.3029 Informative Inherited
Biological Process (BP) cardiovascular system development 0.8331 Informative Inherited
Biological Process (BP) immune response 0.02029 Informative Inherited
Biological Process (BP) defense response 0.3895 Informative Inherited
Biological Process (BP) response to wounding 0.8305 Informative Inherited
Biological Process (BP) cell activation 0.7611 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 1 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.8277 Informative Inherited
Biological Process (BP) nucleocytoplasmic transport 0.353 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.9092 Informative Inherited
Biological Process (BP) protein localization to organelle 1 Informative Inherited
Biological Process (BP) porphyrin-containing compound biosynthetic process 4.278e-05 Highly Informative Direct
Biological Process (BP) cellular calcium ion homeostasis 0.0001446 Highly Informative Direct
Biological Process (BP) meiosis 1.651e-12 Highly Informative Direct
Biological Process (BP) spermatogenesis 8.488e-12 Highly Informative Direct
Biological Process (BP) muscle organ development 1.281e-06 Highly Informative Direct
Biological Process (BP) sensory perception 0.0001879 Highly Informative Direct
Biological Process (BP) response to heat 0.0001778 Highly Informative Direct
Biological Process (BP) cell growth 1.52e-05 Highly Informative Direct
Biological Process (BP) morphogenesis of embryonic epithelium 0.0002241 Highly Informative Direct
Biological Process (BP) protein ubiquitination 0.0001377 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular transport 8.31e-06 Highly Informative Direct
Biological Process (BP) regulation of intracellular protein transport 4.257e-05 Highly Informative Direct
Biological Process (BP) regulation of transmembrane transport 2.303e-06 Highly Informative Direct
Biological Process (BP) regulation of gene expression, epigenetic 7.43e-11 Highly Informative Direct
Biological Process (BP) lipoprotein metabolic process 2.585e-05 Highly Informative Direct
Biological Process (BP) DNA methylation or demethylation 0 Highly Informative Direct
Biological Process (BP) negative regulation of cell cycle 0.0005677 Highly Informative Direct
Biological Process (BP) negative regulation of protein transport 0.0002038 Highly Informative Direct
Biological Process (BP) maintenance of location 3.802e-12 Highly Informative Direct
Biological Process (BP) regulation of ligase activity 0.0001106 Highly Informative Direct
Biological Process (BP) regulation of protein localization to nucleus 0.000161 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.3946 Highly Informative Inherited
Biological Process (BP) regulation of neurological system process 0.3633 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.5 Highly Informative Inherited
Biological Process (BP) positive regulation of protein transport 0.9951 Highly Informative Inherited
Biological Process (BP) protein localization to membrane 0.00973 Highly Informative Inherited
Biological Process (BP) mitotic cell cycle 0.8082 Highly Informative Inherited
Biological Process (BP) cell cycle phase transition 0.004464 Highly Informative Inherited
Biological Process (BP) cell cycle phase 0.4295 Highly Informative Inherited
Biological Process (BP) cellular response to biotic stimulus 0.05963 Highly Informative Inherited
Biological Process (BP) response to lipopolysaccharide 0.008166 Highly Informative Inherited
Biological Process (BP) calcium ion transport 0.1129 Highly Informative Inherited
Biological Process (BP) ion transmembrane transport 0.005884 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.09114 Highly Informative Inherited
Biological Process (BP) multi-multicellular organism process 0.9904 Highly Informative Inherited
Biological Process (BP) protein methylation 1 Highly Informative Inherited
Biological Process (BP) histone modification 0.2282 Highly Informative Inherited
Biological Process (BP) regulation of protein ubiquitination 0.008212 Highly Informative Inherited
Biological Process (BP) positive regulation of sequence-specific DNA binding transcription factor activity 0.1085 Highly Informative Inherited
Biological Process (BP) actin filament organization 0.02681 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.05157 Highly Informative Inherited
Biological Process (BP) erythrocyte differentiation 0.03197 Highly Informative Inherited
Biological Process (BP) developmental growth 0.006904 Highly Informative Inherited
Biological Process (BP) axonogenesis 1 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.5077 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 0.01383 Highly Informative Inherited
Biological Process (BP) positive regulation of cell differentiation 0.6607 Highly Informative Inherited
Biological Process (BP) regulation of myeloid cell differentiation 0.06835 Highly Informative Inherited
Biological Process (BP) regulation of neuron differentiation 0.0244 Highly Informative Inherited
Biological Process (BP) regulation of organ morphogenesis 0.02051 Highly Informative Inherited
Biological Process (BP) regulation of nucleocytoplasmic transport 0.04237 Highly Informative Inherited
Biological Process (BP) modification-dependent protein catabolic process 0.1076 Highly Informative Inherited
Biological Process (BP) regulation of cytokine biosynthetic process 0.01667 Highly Informative Inherited
Biological Process (BP) epidermis development 0.449 Highly Informative Inherited
Biological Process (BP) activation of immune response 0.7274 Highly Informative Inherited
Biological Process (BP) immune response-regulating signaling pathway 0.6032 Highly Informative Inherited
Biological Process (BP) regulation of innate immune response 0.01693 Highly Informative Inherited
Biological Process (BP) negative regulation of signal transduction 0.7321 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.7563 Highly Informative Inherited
Biological Process (BP) regulation of cell adhesion 0.1134 Highly Informative Inherited
Biological Process (BP) chemotaxis 0.602 Highly Informative Inherited
Biological Process (BP) regulation of nucleoside metabolic process 0.7475 Highly Informative Inherited
Biological Process (BP) regulation of purine nucleotide catabolic process 0.5195 Highly Informative Inherited
Biological Process (BP) regulation of Ras protein signal transduction 0.004177 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 0.05118 Highly Informative Inherited
Biological Process (BP) cellular component assembly involved in morphogenesis 0.5916 Highly Informative Inherited
Biological Process (BP) negative regulation of cytoskeleton organization 0.008757 Highly Informative Inherited
Biological Process (BP) regulation of actin cytoskeleton organization 1 Highly Informative Inherited
Biological Process (BP) negative regulation of sequence-specific DNA binding transcription factor activity 0.003162 Highly Informative Inherited
Biological Process (BP) regulation of multi-organism process 0.5718 Highly Informative Inherited
Biological Process (BP) DNA replication 0.9879 Highly Informative Inherited
Biological Process (BP) regulation of microtubule polymerization or depolymerization 0.02491 Highly Informative Inherited
Biological Process (BP) regulation of protein complex assembly 0.7681 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.58 Highly Informative Inherited
Biological Process (BP) regulation of vesicle-mediated transport 0.005556 Highly Informative Inherited
Biological Process (BP) regulation of G-protein coupled receptor protein signaling pathway 0.009464 Highly Informative Inherited
Biological Process (BP) negative regulation of locomotion 0.4417 Highly Informative Inherited
Biological Process (BP) negative regulation of cellular component movement 0.4289 Highly Informative Inherited
Biological Process (BP) cellular response to organic cyclic compound 0.2801 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.001933 Highly Informative Inherited
Biological Process (BP) female gamete generation 1 Highly Informative Inherited
Biological Process (BP) response to osmotic stress 0.2135 Highly Informative Inherited
Biological Process (BP) cellular response to abiotic stimulus 0.2549 Highly Informative Inherited
Biological Process (BP) transition metal ion transport 1 Highly Informative Inherited
Biological Process (BP) glutamine family amino acid catabolic process 0.003104 Highly Informative Inherited
Biological Process (BP) inflammatory response 0.4229 Highly Informative Inherited
Biological Process (BP) protein import 0.1252 Highly Informative Inherited
Biological Process (BP) protein localization to nucleus 0.243 Highly Informative Inherited
Biological Process (BP) protein targeting to nucleus 0.3812 Highly Informative Inherited
Biological Process (BP) nuclear import 0.1929 Highly Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) binding 0.8394 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transporter activity 5.58e-07 Moderately Informative Direct
Molecular Function (MF) protein binding 1.003e-09 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 0.0002698 Moderately Informative Direct
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) structural molecule activity 0.6567 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 1 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) enzyme inhibitor activity 6.274e-05 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0.0008594 Informative Direct
Molecular Function (MF) ligase activity, forming carbon-nitrogen bonds 5.147e-05 Informative Direct
Molecular Function (MF) enzyme binding 8.803e-10 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 8.325e-06 Informative Direct
Molecular Function (MF) inorganic cation transmembrane transporter activity 0.05504 Informative Inherited
Molecular Function (MF) lipid binding 0.05828 Informative Inherited
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring one-carbon groups 0.9814 Informative Inherited
Molecular Function (MF) phosphoric ester hydrolase activity 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 0.1721 Informative Inherited
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 0.03061 Informative Inherited
Molecular Function (MF) kinase activity 1 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 1 Informative Inherited
Molecular Function (MF) ion channel activity 0 Highly Informative Direct
Molecular Function (MF) small conjugating protein ligase activity 2.013e-07 Highly Informative Direct
Molecular Function (MF) protein kinase regulator activity 1.091e-10 Highly Informative Direct
Molecular Function (MF) alcohol binding 9.772e-05 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0.03853 Highly Informative Inherited
Molecular Function (MF) glycolipid binding 0.001553 Highly Informative Inherited
Molecular Function (MF) methyltransferase activity 0.8985 Highly Informative Inherited
Molecular Function (MF) phosphoprotein phosphatase activity 0.3745 Highly Informative Inherited
Molecular Function (MF) ion gated channel activity 0.8814 Highly Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1.744e-06 Least Informative Direct
Cellular Component (CC) membrane 0.9689 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) cell projection 1.921e-05 Moderately Informative Direct
Cellular Component (CC) extracellular region 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) ribonucleoprotein complex 0.2527 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.7314 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.9211 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 0.0535 Moderately Informative Inherited
Cellular Component (CC) cell cortex 0.0001896 Informative Direct
Cellular Component (CC) cell junction 2.48e-09 Informative Direct
Cellular Component (CC) contractile fiber part 2.4e-05 Informative Direct
Cellular Component (CC) cell projection part 4.205e-05 Informative Direct
Cellular Component (CC) synapse 6.36e-06 Informative Direct
Cellular Component (CC) neuron part 2.047e-06 Informative Direct
Cellular Component (CC) endosome 0.3538 Informative Inherited
Cellular Component (CC) Golgi apparatus 0.004466 Informative Inherited
Cellular Component (CC) chromosome 1 Informative Inherited
Cellular Component (CC) nucleoplasm part 1 Informative Inherited
Cellular Component (CC) actin cytoskeleton 0.269 Informative Inherited
Cellular Component (CC) Golgi membrane 2.819e-08 Highly Informative Direct
Cellular Component (CC) actin filament 2.686e-05 Highly Informative Direct
Cellular Component (CC) adherens junction 1.926e-08 Highly Informative Direct
Cellular Component (CC) axon part 2.847e-08 Highly Informative Direct
Cellular Component (CC) membrane raft 1.446e-05 Highly Informative Direct
Cellular Component (CC) synaptic membrane 4.083e-12 Highly Informative Direct
Cellular Component (CC) protein serine/threonine phosphatase complex 0.03277 Highly Informative Inherited
Cellular Component (CC) endosomal part 0.1459 Highly Informative Inherited
Cellular Component (CC) recycling endosome 0.02442 Highly Informative Inherited
Cellular Component (CC) transcription elongation factor complex 0.004266 Highly Informative Inherited
Cellular Component (CC) trans-Golgi network 0.1459 Highly Informative Inherited
Cellular Component (CC) transcription factor complex 1 Highly Informative Inherited
Cellular Component (CC) cell-cell junction 1 Highly Informative Inherited
Cellular Component (CC) replisome 0.001034 Highly Informative Inherited
Cellular Component (CC) nuclear chromosome part 0.5585 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides0.4016Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds0.1213Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)In linear amides1.232e-09Moderately InformativeDirect
Enzyme Commission (EC)Carboxylic ester hydrolases0.0008122Moderately InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides0.001342Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep1Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases0.3822Moderately InformativeInherited
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase3.44e-13InformativeDirect
Enzyme Commission (EC)Diacylglycerol kinase2.201e-13Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)benign neoplasm0.03099Moderately InformativeInherited
Disease Ontology (DO)organ system benign neoplasm0.2612InformativeInherited
Disease Ontology (DO)skin hemangioma5.302e-06Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.2891Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.3145Least InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.09302Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.2422Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal Peyer's patch morphology0.03862InformativeInherited
Mammalian Phenotype (MP)abnormal skin appearance0.5739InformativeInherited
Mammalian Phenotype (MP)extramedullary hematopoiesis0.0001638Highly InformativeDirect
Mammalian Phenotype (MP)scaly skin0.0004444Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.01108Least InformativeInherited
Worm Phenotype (WP)chemical response variant0.9899Moderately InformativeInherited
Worm Phenotype (WP)organism stress response variant3.662e-05InformativeDirect
Worm Phenotype (WP)chemotaxis variant0.0001255InformativeDirect
Worm Phenotype (WP)negative chemotaxis variant0.01861Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)cell cycle progression0.05687InformativeInherited

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)sensory perception defective6.229e-09InformativeDirect
Fly Phenotype (FP)neurophysiology defective1.136e-06InformativeDirect
Fly Phenotype (FP)thermotaxis behavior defective2.324e-05Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system subdivision0.06939Least InformativeInherited
Fly Anatomy (FA)cell0.211Least InformativeInherited
Fly Anatomy (FA)organ system0.2701Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)tagmatic subdivision of integument0.1297Moderately InformativeInherited
Fly Anatomy (FA)neuron0.1825Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.3006Moderately InformativeInherited
Fly Anatomy (FA)appendage0.3675Moderately InformativeInherited
Fly Anatomy (FA)sense organ0.3839Moderately InformativeInherited
Fly Anatomy (FA)adult segment0.6408Moderately InformativeInherited
Fly Anatomy (FA)head0.7578Moderately InformativeInherited
Fly Anatomy (FA)adult external head0.04933InformativeInherited
Fly Anatomy (FA)procephalic segment0.09381InformativeInherited
Fly Anatomy (FA)appendage segment0.1328InformativeInherited
Fly Anatomy (FA)adult head segment0.1534InformativeInherited
Fly Anatomy (FA)sensory neuron0.1535InformativeInherited
Fly Anatomy (FA)mechanosensory sensory organ0.5353InformativeInherited
Fly Anatomy (FA)antennal sense organ0.004935Highly InformativeInherited
Fly Anatomy (FA)chordotonal organ0.0289Highly InformativeInherited

Document: FA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups1.197e-07Least InformativeDirect
Enzyme Commission (EC)Hydrolases0.003244Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds0.0002746Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.4518Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases0.4535Moderately InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect
Enzyme Commission (EC)In linear amides8.57e-11InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase1.792e-07InformativeDirect
Enzyme Commission (EC)Carboxylic ester hydrolases0.0009147InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides0.001415InformativeInherited
Enzyme Commission (EC)Phosphoric diester hydrolases0.001477InformativeInherited
Enzyme Commission (EC)Pentosyltransferases0.006996InformativeInherited
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase2.652e-13Highly InformativeDirect
Enzyme Commission (EC)Diacylglycerol kinase4.075e-13Highly InformativeDirect
Enzyme Commission (EC)Lysophospholipase6.266e-05Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processDifferentiation0Moderately InformativeDirect
Biological processIon transport4.689e-11Moderately InformativeDirect
Biological processApoptosis1.788e-07Moderately InformativeDirect
Biological processHost-virus interaction0.0002485Moderately InformativeDirect
Biological processMeiosis0InformativeDirect
Biological processUbl conjugation pathway0InformativeDirect
Biological processWnt signaling pathway6.745e-07InformativeDirect
Biological processNotch signaling pathway0Highly InformativeDirect
Biological processRNA-mediated gene silencing0Highly InformativeDirect
Biological processSpermatogenesis2.804e-13Highly InformativeDirect
Biological processExocytosis1.931e-07Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentMembrane5.807e-06Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentGolgi apparatus0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentCell junction3.223e-16Moderately InformativeDirect
Cellular componentEndosome1.58e-15Moderately InformativeDirect
Cellular componentCytoskeleton8.896e-08Moderately InformativeDirect
Cellular componentPostsynaptic cell membrane9.295e-14InformativeDirect
Cellular componentCentromere0.0003831Highly InformativeDirect
Coding sequence diversityAlternative splicing2.062e-05Least InformativeDirect
DiseaseTumor suppressor4.533e-06Moderately InformativeDirect
DomainRepeat0Least InformativeDirect
DomainCoiled coil1.23e-12Moderately InformativeDirect
DomainANK repeat0InformativeDirect
DomainSH3 domain5.968e-08InformativeDirect
DomainTPR repeat1.149e-05Highly InformativeDirect
Molecular functionZinc1.956e-08Least InformativeDirect
Molecular functionMetal-binding1Least InformativeInherited
Molecular functionZinc-finger0Moderately InformativeDirect
Molecular functionCalcium6.002e-11Moderately InformativeDirect
Molecular functionCalmodulin-binding0InformativeDirect
Molecular functionLipid-binding1.496e-05InformativeDirect
Molecular functionPotassium0.04964InformativeInherited
Molecular functionCalcium channel0Highly InformativeDirect
Molecular functionCalcium transport0Highly InformativeDirect
Molecular functionPotassium channel9.861e-11Highly InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationActivator7.788e-10Moderately InformativeDirect
Post-translational modificationKinase1Moderately InformativeInherited
Post-translational modificationGTPase activation0InformativeDirect
Post-translational modificationIon channel0InformativeDirect
Post-translational modificationSerine/threonine-protein kinase1.281e-05InformativeDirect
Post-translational modificationToxin1InformativeInherited
Post-translational modificationNeurotoxin0.0747Highly InformativeInherited
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation2.504e-05Moderately InformativeDirect
Post-translational modificationHydroxylation1.623e-12InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR002110 SSF48403 Protein matches
Abstract

The ankyrin repeat is one of the most common protein-protein interaction motifs in nature. Ankyrin repeats are tandemly repeated modules of about 33 amino acids. They occur in a large number of functionally diverse proteins mainly from eukaryotes. The few known examples from prokaryotes and viruses may be the result of horizontal gene transfers [PubMed8108379]. The repeat has been found in proteins of diverse function such as transcriptional initiators, cell-cycle regulators, cytoskeletal, ion transporters and signal transducers. The ankyrin fold appears to be defined by its structure rather than its function since there is no specific sequence or structure which is universally recognised by it.

The conserved fold of the ankyrin repeat unit is known from several crystal and solution structures [PubMed8875926, PubMed9353127, PubMed9461436, PubMed9865693]. Each repeat folds into a helix-loop-helix structure with a beta-hairpin/loop region projecting out from the helices at a 90o angle. The repeats stack together to form an L-shaped structure [PubMed8875926, PubMed12461176].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 19 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Ankyrin repeat domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 19 hidden Markov models representing the Ankyrin repeat superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]