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Sec7 domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   alpha-alpha superhelix [ 48370] (24)
Superfamily:   Sec7 domain [ 48425]
Families:   Sec7 domain [ 48426] (5)


Superfamily statistics
Genomes (531) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 3,722 3,953 10
Proteins 3,704 3,937 10


Functional annotation
General category Regulation
Detailed category Other regulatory function

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 0.000002924 Least Informative Direct
Biological Process (BP) biological regulation 0.002425 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.3164 Least Informative Inherited
Biological Process (BP) regulation of signaling 0.000000408 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0.00001183 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 0.00002028 Moderately Informative Direct
Biological Process (BP) organelle organization 0.00004163 Moderately Informative Direct
Biological Process (BP) cellular developmental process 0.1285 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.2582 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.06153 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.779 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.1818 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.0146 Moderately Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.000000000000897 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.00000009052 Informative Direct
Biological Process (BP) actin filament-based process 0.0000002476 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0.00001883 Informative Direct
Biological Process (BP) behavior 0.00008834 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.0004347 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0.0004511 Informative Direct
Biological Process (BP) regulation of organelle organization 0.01972 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 0.0432 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.04319 Informative Inherited
Biological Process (BP) endomembrane system organization 0.00000000007426 Highly Informative Direct
Biological Process (BP) multi-organism behavior 0.000000003767 Highly Informative Direct
Biological Process (BP) regulation of GTPase activity 0.00000009083 Highly Informative Direct
Biological Process (BP) Golgi vesicle transport 0.00000192 Highly Informative Direct
Biological Process (BP) pigmentation 0.0000143 Highly Informative Direct
Biological Process (BP) muscle structure development 0.002213 Highly Informative Inherited
Molecular Function (MF) binding 0.0001184 Least Informative Direct
Molecular Function (MF) molecular function regulator 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.0000004568 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0.2724 Moderately Informative Inherited
Molecular Function (MF) phospholipid binding 0.00009455 Informative Direct
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0 Highly Informative Direct
Molecular Function (MF) alcohol binding 0.000000008919 Highly Informative Direct
Molecular Function (MF) cell adhesion molecule binding 0.0000007386 Highly Informative Direct
Cellular Component (CC) membrane 0.0000000005986 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.05413 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.001251 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.0755 Least Informative Inherited
Cellular Component (CC) bounding membrane of organelle 0.00000000119 Moderately Informative Direct
Cellular Component (CC) cell projection 0.000006766 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.00006847 Moderately Informative Direct
Cellular Component (CC) Golgi apparatus 0 Informative Direct
Cellular Component (CC) extrinsic component of membrane 0.0000006726 Informative Direct
Cellular Component (CC) cell surface 0.00002863 Informative Direct
Cellular Component (CC) synapse 0.008603 Informative Inherited
Cellular Component (CC) plasma membrane region 0.001188 Informative Inherited
Cellular Component (CC) plasma membrane bounded cell projection part 0.0203 Informative Inherited
Cellular Component (CC) side of membrane 0.01055 Informative Inherited
Cellular Component (CC) neuron projection 1 Informative Inherited
Cellular Component (CC) Golgi subcompartment 0 Highly Informative Direct
Cellular Component (CC) cell division site part 0.00000000000016 Highly Informative Direct
Cellular Component (CC) ruffle 0.0000000000002112 Highly Informative Direct
Cellular Component (CC) extrinsic component of cytoplasmic side of plasma membrane 0.0000002472 Highly Informative Direct
Cellular Component (CC) dendrite 0.0002607 Highly Informative Direct

Document: GO annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)larval lethal0Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval growth variant0Least InformativeDirect
Worm Phenotype (WP)endocytic transport defect0InformativeDirect
Worm Phenotype (WP)cell number increased0.00000009116InformativeDirect
Worm Phenotype (WP)extra excretory cells0.0000000000006594Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0Least InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)sporangium0Least InformativeDirect
Plant structure DEvelopment stage (PDE)pollen development stage0.002144Moderately InformativeInherited
Plant structure DEvelopment stage (PDE)L mature pollen stage0.0004954InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.0000002395Least InformativeDirect
Biological processProtein transport0Moderately InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCytoplasm0.0000214Least InformativeDirect
Cellular componentCell projection0.0000000000002271Moderately InformativeDirect
Cellular componentGolgi apparatus0.0000000000004743Moderately InformativeDirect
Cellular componentEndosome0.00002233Moderately InformativeDirect
Cellular componentCell junction0.00007207Moderately InformativeDirect
Cellular componentSynapse0.0000004872InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
Molecular functionLipid-binding0Moderately InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor0InformativeDirect
Post-translational modificationPhosphoprotein0.00000000000205Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR000904 SSF48425 Protein matches
Abstract The SEC7 domain was named after the first protein found to contain such a region [PubMed3042778]. It has been shown to be linked with guanine nucleotide exchange function [PubMed9072969, PubMed9442017]. The 3D structure of the domain displays several alpha-helices [PubMed9653114]. It was found to be associated with other domains involved in guanine nucleotide exchange (e.g., CDC25, Dbl) in mammalian factors [PubMed9868368].

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 6 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Sec7 domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 6 hidden Markov models representing the Sec7 domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]