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Sec7 domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   alpha-alpha superhelix [ 48370] (24)
Superfamily:   Sec7 domain [ 48425]
Families:   Sec7 domain [ 48426] (5)


Superfamily statistics
Genomes (527) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 3,687 3,953 10
Proteins 3,669 3,937 10


Functional annotation
General category Regulation
Detailed category Other regulatory function

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biological regulation 0.0005468 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.000002768 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.5466 Least Informative Inherited
Biological Process (BP) organelle organization 0.0000003576 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 0.00002426 Moderately Informative Direct
Biological Process (BP) regulation of signaling 0.0000005774 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0.00001371 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.2507 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.2442 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.06012 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 0.1611 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.8551 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.9809 Moderately Informative Inherited
Biological Process (BP) system development 0.9653 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.03563 Moderately Informative Inherited
Biological Process (BP) behavior 0.00006595 Informative Direct
Biological Process (BP) post-embryonic development 0.0004431 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.00000001308 Informative Direct
Biological Process (BP) actin filament-based process 0.0000001305 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.0002837 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0.000249 Informative Direct
Biological Process (BP) epithelium development 0.000004789 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0.00001081 Informative Direct
Biological Process (BP) regulation of intracellular signal transduction 0.0000000000003697 Informative Direct
Biological Process (BP) regulation of organelle organization 0.00545 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 0.04394 Informative Inherited
Biological Process (BP) secretion 0.002192 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.0368 Informative Inherited
Biological Process (BP) metamorphosis 0.000001163 Highly Informative Direct
Biological Process (BP) endomembrane system organization 0.00000000004343 Highly Informative Direct
Biological Process (BP) tube morphogenesis 0.000005372 Highly Informative Direct
Biological Process (BP) pigmentation 0.00001025 Highly Informative Direct
Biological Process (BP) Golgi vesicle transport 0.0000005618 Highly Informative Direct
Biological Process (BP) instar larval or pupal morphogenesis 0.000000005367 Highly Informative Direct
Biological Process (BP) appendage development 0.000003695 Highly Informative Direct
Biological Process (BP) multi-organism behavior 0.000000001411 Highly Informative Direct
Biological Process (BP) regulation of response to wounding 0.0000007355 Highly Informative Direct
Biological Process (BP) morphogenesis of an epithelium 0.05982 Highly Informative Inherited
Biological Process (BP) muscle structure development 0.001613 Highly Informative Inherited
Molecular Function (MF) binding 0.0001756 Least Informative Direct
Molecular Function (MF) anion binding 0.0000001532 Moderately Informative Direct
Molecular Function (MF) molecular function regulator 0 Moderately Informative Direct
Molecular Function (MF) protein binding 0.00985 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 0.188 Moderately Informative Inherited
Molecular Function (MF) phospholipid binding 0.0001117 Informative Direct
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0 Highly Informative Direct
Molecular Function (MF) alcohol binding 0.000000005619 Highly Informative Direct
Cellular Component (CC) membrane 0.0000001171 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.0002156 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.06088 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.02643 Least Informative Inherited
Cellular Component (CC) organelle membrane 0.00006252 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.04411 Moderately Informative Inherited
Cellular Component (CC) Golgi apparatus 0 Informative Direct
Cellular Component (CC) extrinsic component of membrane 0.00000001569 Informative Direct
Cellular Component (CC) organelle subcompartment 0 Informative Direct
Cellular Component (CC) side of membrane 0.0125 Informative Inherited
Cellular Component (CC) cell junction 0.007391 Informative Inherited
Cellular Component (CC) extrinsic component of cytoplasmic side of plasma membrane 0.0000001994 Highly Informative Direct
Cellular Component (CC) anchoring junction 0.03233 Highly Informative Inherited

Document: GO annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)larval lethal0Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval growth variant0Least InformativeDirect
Worm Phenotype (WP)endocytic transport defect0InformativeDirect
Worm Phenotype (WP)cell number increased0.00000009727InformativeDirect
Worm Phenotype (WP)extra excretory cells0.0000000000006471Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0Least InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)sporangium0Least InformativeDirect
Plant structure DEvelopment stage (PDE)pollen development stage0.002144Moderately InformativeInherited
Plant structure DEvelopment stage (PDE)L mature pollen stage0.0004954InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.0000002399Least InformativeDirect
Biological processProtein transport0Moderately InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCytoplasm0.00002087Least InformativeDirect
Cellular componentCell projection0.0000000000001127Moderately InformativeDirect
Cellular componentGolgi apparatus0.0000000000004485Moderately InformativeDirect
Cellular componentEndosome0.00002003Moderately InformativeDirect
Cellular componentCell junction0.00006833Moderately InformativeDirect
Cellular componentSynapse0.0000004488InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
Molecular functionLipid-binding0Moderately InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor0InformativeDirect
Post-translational modificationPhosphoprotein0.000000000001931Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR000904 SSF48425 Protein matches
Abstract The SEC7 domain was named after the first protein found to contain such a region [PubMed3042778]. It has been shown to be linked with guanine nucleotide exchange function [PubMed9072969, PubMed9442017]. The 3D structure of the domain displays several alpha-helices [PubMed9653114]. It was found to be associated with other domains involved in guanine nucleotide exchange (e.g., CDC25, Dbl) in mammalian factors [PubMed9868368].

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 6 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Sec7 domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 6 hidden Markov models representing the Sec7 domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]