SUPERFAMILY 1.75 HMM library and genome assignments server


Sec7 domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   alpha-alpha superhelix [ 48370] (24)
Superfamily:   Sec7 domain [ 48425]
Families:   Sec7 domain [ 48426] (5)


Superfamily statistics
Genomes (525) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 3,649 3,953 10
Proteins 3,631 3,937 10


Functional annotation
General category Regulation
Detailed category Other regulatory function

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of metabolic process 7.344e-09 Least Informative Direct
Biological Process (BP) localization 2.897e-05 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 6.311e-05 Least Informative Direct
Biological Process (BP) single-organism cellular process 9.543e-05 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.1974 Least Informative Inherited
Biological Process (BP) developmental process 0.3231 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.6738 Least Informative Inherited
Biological Process (BP) response to stimulus 0.5777 Least Informative Inherited
Biological Process (BP) regulation of catalytic activity 0 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.0001012 Moderately Informative Direct
Biological Process (BP) organelle organization 0.000131 Moderately Informative Direct
Biological Process (BP) cellular localization 0.0003679 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 0.0008124 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.02126 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.1529 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.6316 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.4332 Moderately Informative Inherited
Biological Process (BP) organ development 0.09655 Moderately Informative Inherited
Biological Process (BP) tissue development 0.01271 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.05128 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.007441 Moderately Informative Inherited
Biological Process (BP) regulation of nucleoside metabolic process 0 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 3.921e-09 Informative Direct
Biological Process (BP) vesicle-mediated transport 9.81e-07 Informative Direct
Biological Process (BP) regulation of anatomical structure size 8.301e-06 Informative Direct
Biological Process (BP) actin filament-based process 1.378e-05 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 6.813e-05 Informative Direct
Biological Process (BP) organ morphogenesis 0.0001262 Informative Direct
Biological Process (BP) cellular membrane organization 0.0001294 Informative Direct
Biological Process (BP) muscle tissue development 0.0004297 Informative Direct
Biological Process (BP) muscle structure development 0.000437 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.05997 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.01706 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.1011 Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 1.806e-11 Highly Informative Direct
Biological Process (BP) Golgi vesicle transport 2.563e-10 Highly Informative Direct
Biological Process (BP) multi-organism behavior 1.575e-08 Highly Informative Direct
Biological Process (BP) post-embryonic organ development 4.044e-08 Highly Informative Direct
Biological Process (BP) post-embryonic development 3.665e-05 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 6.213e-05 Highly Informative Direct
Biological Process (BP) muscle organ development 6.484e-05 Highly Informative Direct
Biological Process (BP) regulation of protein complex assembly 0.0006551 Highly Informative Direct
Biological Process (BP) regulation of actin cytoskeleton organization 0.2558 Highly Informative Inherited
Molecular Function (MF) binding 8.751e-06 Least Informative Direct
Molecular Function (MF) enzyme regulator activity 0 Moderately Informative Direct
Molecular Function (MF) anion binding 4.462e-10 Moderately Informative Direct
Molecular Function (MF) GTPase regulator activity 0 Informative Direct
Molecular Function (MF) lipid binding 2.284e-08 Informative Direct
Molecular Function (MF) phosphatidylinositol binding 0 Highly Informative Direct
Molecular Function (MF) alcohol binding 2.013e-08 Highly Informative Direct
Molecular Function (MF) guanyl-nucleotide exchange factor activity 4.907e-08 Highly Informative Direct
Molecular Function (MF) small GTPase regulator activity 0.2765 Highly Informative Inherited
Cellular Component (CC) membrane 1.343e-07 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.9325 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.2603 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.08416 Least Informative Inherited
Cellular Component (CC) endomembrane system 3.983e-05 Moderately Informative Direct
Cellular Component (CC) cell projection 0.0002932 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0.05169 Moderately Informative Inherited
Cellular Component (CC) Golgi apparatus 0 Informative Direct
Cellular Component (CC) cell leading edge 1.497e-06 Informative Direct
Cellular Component (CC) neuron projection 1 Informative Inherited
Cellular Component (CC) cell-cell junction 1 Informative Inherited
Cellular Component (CC) trans-Golgi network 9.829e-13 Highly Informative Direct
Cellular Component (CC) adherens junction 0.0001915 Highly Informative Direct
Cellular Component (CC) dendrite 0.0002814 Highly Informative Direct

Document: GO annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Moderately InformativeDirect
Worm Phenotype (WP)endocytic transport defect0Moderately InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)anatomical group0Least InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)sporangium0Least InformativeDirect
Plant structure DEvelopment stage (PDE)pollen development stage0.002141Moderately InformativeInherited
Plant structure DEvelopment stage (PDE)L mature pollen stage0.0004945InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport3.539e-06Least InformativeDirect
Biological processProtein transport0Moderately InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCytoplasm0.0001235Least InformativeDirect
Cellular componentGolgi apparatus4.067e-11Moderately InformativeDirect
Cellular componentCell projection2.858e-08Moderately InformativeDirect
Cellular componentEndosome6.727e-06Moderately InformativeDirect
Cellular componentCell junction2.491e-05Moderately InformativeDirect
Cellular componentSynapse2.339e-07InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
Molecular functionLipid-binding0InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor0InformativeDirect
Post-translational modificationPhosphoprotein1.294e-10Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR000904 SSF48425 Protein matches
Abstract The SEC7 domain was named after the first protein found to contain such a region [PubMed3042778]. It has been shown to be linked with guanine nucleotide exchange function [PubMed9072969, PubMed9442017]. The 3D structure of the domain displays several alpha-helices [PubMed9653114]. It was found to be associated with other domains involved in guanine nucleotide exchange (e.g., CDC25, Dbl) in mammalian factors [PubMed9868368].

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 6 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Sec7 domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 6 hidden Markov models representing the Sec7 domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]