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Sec7 domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   alpha-alpha superhelix [ 48370] (24)
Superfamily:   Sec7 domain [ 48425]
Families:   Sec7 domain [ 48426] (5)


Superfamily statistics
Genomes (534) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 3,767 9,376 10
Proteins 3,749 9,336 10


Functional annotation
General category Regulation
Detailed category Other regulatory function

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0.0009438 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.000009089 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.5416 Least Informative Inherited
Biological Process (BP) biological regulation 0.00948 Least Informative Inherited
Biological Process (BP) organelle organization 0.00002082 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 0.000007693 Moderately Informative Direct
Biological Process (BP) regulation of signaling 0.0000001281 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0.00001653 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.4865 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.03055 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.2965 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.02767 Moderately Informative Inherited
Biological Process (BP) single-organism transport 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.4353 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.9916 Moderately Informative Inherited
Biological Process (BP) nitrogen compound transport 0.6184 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.006173 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.1698 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.261 Moderately Informative Inherited
Biological Process (BP) behavior 0.000005858 Informative Direct
Biological Process (BP) protein transport 0.0005574 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.00000004001 Informative Direct
Biological Process (BP) actin cytoskeleton organization 0.0009268 Informative Direct
Biological Process (BP) secretion by cell 0.0002817 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.0002358 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0.0007864 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0.000005087 Informative Direct
Biological Process (BP) regulation of intracellular signal transduction 0.000000000004765 Informative Direct
Biological Process (BP) regulation of organelle organization 0.0183 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 0.02511 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.01163 Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 0.0004841 Highly Informative Direct
Biological Process (BP) endomembrane system organization 0.000000000005571 Highly Informative Direct
Biological Process (BP) regulation of GTPase activity 0.00000001001 Highly Informative Direct
Biological Process (BP) pigmentation 0.000002491 Highly Informative Direct
Biological Process (BP) Golgi vesicle transport 0.000004427 Highly Informative Direct
Biological Process (BP) multi-organism behavior 0.00000002024 Highly Informative Direct
Biological Process (BP) regulation of response to wounding 0.000002628 Highly Informative Direct
Molecular Function (MF) binding 0.001168 Least Informative Inherited
Molecular Function (MF) anion binding 0.000001287 Moderately Informative Direct
Molecular Function (MF) molecular function regulator 0 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0.2606 Moderately Informative Inherited
Molecular Function (MF) phospholipid binding 0.0001133 Informative Direct
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0 Highly Informative Direct
Molecular Function (MF) alcohol binding 0.00000001252 Highly Informative Direct
Molecular Function (MF) cell adhesion molecule binding 0.0000006912 Highly Informative Direct
Molecular Function (MF) phosphatidylinositol phosphate binding 0.000000000002321 Highly Informative Direct
Cellular Component (CC) membrane 0.00000000000001446 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.00003743 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.00003654 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.008181 Least Informative Inherited
Cellular Component (CC) endomembrane system 0 Moderately Informative Direct
Cellular Component (CC) cell projection 0.0001269 Moderately Informative Direct
Cellular Component (CC) bounding membrane of organelle 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.002995 Moderately Informative Inherited
Cellular Component (CC) Golgi apparatus 0 Informative Direct
Cellular Component (CC) cell surface 0.000183 Informative Direct
Cellular Component (CC) extrinsic component of membrane 0.00000078 Informative Direct
Cellular Component (CC) side of membrane 0.01115 Informative Inherited
Cellular Component (CC) plasma membrane region 0.008487 Informative Inherited
Cellular Component (CC) plasma membrane bounded cell projection part 0.01794 Informative Inherited
Cellular Component (CC) neuron projection 1 Informative Inherited
Cellular Component (CC) ruffle 0.0000000000001106 Highly Informative Direct
Cellular Component (CC) cis-Golgi network 0.0000000008004 Highly Informative Direct
Cellular Component (CC) dendrite 0.0005748 Highly Informative Direct
Cellular Component (CC) extrinsic component of cytoplasmic side of plasma membrane 0.0000007672 Highly Informative Direct
Cellular Component (CC) cell division site part 0.00000000000181 Highly Informative Direct
Cellular Component (CC) Golgi subcompartment 0 Highly Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.0000002449Least InformativeDirect
Biological processProtein transport0Moderately InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCytoplasm0.00001961Least InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentGolgi apparatus0.0000000000004298Moderately InformativeDirect
Cellular componentEndosome0.00002291Moderately InformativeDirect
Cellular componentCell junction0.0000732Moderately InformativeDirect
Cellular componentSynapse0.0000004909InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
Molecular functionLipid-binding0Moderately InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor0InformativeDirect
Post-translational modificationPhosphoprotein0.00000000000173Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR000904 SSF48425 Protein matches
Abstract The SEC7 domain was named after the first protein found to contain such a region [PubMed3042778]. It has been shown to be linked with guanine nucleotide exchange function [PubMed9072969, PubMed9442017]. The 3D structure of the domain displays several alpha-helices [PubMed9653114]. It was found to be associated with other domains involved in guanine nucleotide exchange (e.g., CDC25, Dbl) in mammalian factors [PubMed9868368].

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 6 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Sec7 domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 6 hidden Markov models representing the Sec7 domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]