SUPERFAMILY 1.75 HMM library and genome assignments server

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TPR-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   alpha-alpha superhelix [ 48370] (24)
Superfamily:   TPR-like [ 48452] (8)
Families:   Tetratricopeptide repeat (TPR) [ 48453] (17)
  Transcription factor MalT domain III [ 69094]
  BTAD-like [ 140845]
  PrgX C-terminal domain-like [ 140848]
  Atu0120-like [ 158772]
  SusD-like [ 158775] (3)
  HAT/Suf repeat [ 158782]
  CT2138-like [ 158785]


Superfamily statistics
Genomes (3,133) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 169,526 955,257 50
Proteins 125,432 730,800 49


Functional annotation
General category General
Detailed category Protein interaction

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Isomerases0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0.5472Least InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases0.003141Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups0.5544Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases0.1413Least InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.0012Moderately InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0.002744Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases0.3264Moderately InformativeInherited
Enzyme Commission (EC)Methyltransferases0.1514Moderately InformativeInherited
Enzyme Commission (EC)Peptidylprolyl isomerase0InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase0.000000000004361InformativeDirect
Enzyme Commission (EC)Phosphoprotein phosphatase0.000000007897InformativeDirect
Enzyme Commission (EC)With 2-oxoglutarate as one donor, and incorporatio0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)genetic disease0.7218Moderately InformativeInherited
Disease Ontology (DO)autosomal recessive disease0.3351InformativeInherited
Disease Ontology (DO)Bardet-Biedl syndrome0.0002735Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the skeletal system0.2163Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.2766Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.3709Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.5749Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.7418Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limb bone morphology0.1741Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.2777Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper urinary tract0.422Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system morphology0.5072Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal renal morphology0.1461InformativeInherited
Phenotypic Abnormality (PA)Nephronophthisis0.000453Highly InformativeDirect
Phenotypic Abnormality (PA)Hepatic fibrosis0.0007892Highly InformativeDirect
Phenotypic Abnormality (PA)Polydactyly0.02882Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.1092Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal kidney epithelium morphology0.0009136Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organ system morphology variant0.0000001965Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.0000005194Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0.000649Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.01525Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.02556Least InformativeInherited
Worm Phenotype (WP)cell development variant0.03286Least InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.00003535Moderately InformativeDirect
Worm Phenotype (WP)gametogenesis variant0.03047Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.05033Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.06367Moderately InformativeInherited
Worm Phenotype (WP)nervous system morphology variant0.1005Moderately InformativeInherited
Worm Phenotype (WP)cell component morphology variant0.3366Moderately InformativeInherited
Worm Phenotype (WP)reproductive system development variant0.3527Moderately InformativeInherited
Worm Phenotype (WP)sensillum morphology variant0.00000002622InformativeDirect
Worm Phenotype (WP)male morphology variant0.00009237InformativeDirect
Worm Phenotype (WP)embryonic cell organization biogenesis variant0.0002982InformativeDirect
Worm Phenotype (WP)somatic gonad development variant0.0004339InformativeDirect
Worm Phenotype (WP)mechanosensation variant0.01294InformativeInherited
Worm Phenotype (WP)copulation variant0.03804InformativeInherited
Worm Phenotype (WP)sexually dimorphic behavior variant0.03908InformativeInherited
Worm Phenotype (WP)positive chemotaxis variant0.07443InformativeInherited
Worm Phenotype (WP)mitotic spindle defective early emb0.00001837Highly InformativeDirect
Worm Phenotype (WP)pronucleus centrosomes defective early emb0.0002589Highly InformativeDirect
Worm Phenotype (WP)dauer development variant0.0004495Highly InformativeDirect
Worm Phenotype (WP)multiple nuclei0.0007234Highly InformativeDirect
Worm Phenotype (WP)cell cycle variant0.003746Highly InformativeInherited
Worm Phenotype (WP)touch resistant0.3037Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)nervous system0.6724Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.9649Least InformativeInherited
Fly Anatomy (FA)adult1Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.1783Moderately InformativeInherited
Fly Anatomy (FA)head0.8842Moderately InformativeInherited
Fly Anatomy (FA)adult segment0.909Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.9988Moderately InformativeInherited
Fly Anatomy (FA)adult nervous system1Moderately InformativeInherited
Fly Anatomy (FA)antennal segment0.08043InformativeInherited
Fly Anatomy (FA)nerve0.1732InformativeInherited
Fly Anatomy (FA)adult procephalic segment0.4427InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)embryonic structure0.07332InformativeInherited

Document: ZA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)seed0.00000001357Least InformativeDirect
Plant ANatomical entity (PAN)whole plant0.04222Least InformativeInherited
Plant ANatomical entity (PAN)shoot axis0.1747Least InformativeInherited
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0.00004502Least InformativeDirect
Plant structure DEvelopment stage (PDE)0 seed germination stage0InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0.04715Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases0.4811Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Isomerases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0.0000001036Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.0000002369Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.001513Moderately InformativeInherited
Enzyme Commission (EC)Aminoacyltransferases0.002107Moderately InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases0.06641Moderately InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Moderately InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0InformativeDirect
Enzyme Commission (EC)Hexosyltransferases0InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0.000000000001384InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase0.00000000001732InformativeDirect
Enzyme Commission (EC)RING-type E3 ubiquitin transferase0.00004561InformativeDirect
Enzyme Commission (EC)Phosphorus-oxygen lyases1InformativeInherited
Enzyme Commission (EC)With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors0Highly InformativeDirect
Enzyme Commission (EC)Peptidylprolyl isomerase0Highly InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine phosphatase0.00000000256Highly InformativeDirect
Enzyme Commission (EC)Adenylate cyclase0.000001947Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 51 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a TPR-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 51 hidden Markov models representing the TPR-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]