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TPR-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   alpha-alpha superhelix [ 48370] (24)
Superfamily:   TPR-like [ 48452] (8)
Families:   Tetratricopeptide repeat (TPR) [ 48453] (17)
  Transcription factor MalT domain III [ 69094]
  BTAD-like [ 140845]
  PrgX C-terminal domain-like [ 140848]
  Atu0120-like [ 158772]
  SusD-like [ 158775] (3)
  HAT/Suf repeat [ 158782]
  CT2138-like [ 158785]


Superfamily statistics
Genomes (3,131) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 168,733 725,715 50
Proteins 124,886 556,248 49


Functional annotation
General category General
Detailed category Protein interaction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular component organization or biogenesis0.000067160.00000000043Least InformativeDirect
Biological Process (BP)biological regulation11Least InformativeInherited
Biological Process (BP)macromolecule localization0.00030260.000000000000001945Moderately InformativeDirect
Biological Process (BP)regulation of response to stimulus11Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process11Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.98560.8718Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.11880.9882Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.41881Moderately InformativeInherited
Biological Process (BP)cellular localization0.0030Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.93011Moderately InformativeInherited
Biological Process (BP)nitrogen compound transport0.016620.00000000000112Moderately InformativeInherited
Biological Process (BP)generation of precursor metabolites and energy0.54311Moderately InformativeInherited
Biological Process (BP)organic substance transport0.10240.0000003196Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.98441Moderately InformativeInherited
Biological Process (BP)organelle organization0.35270Moderately InformativeInherited
Biological Process (BP)mitochondrion organization0.0000019320.0008439InformativeDirect
Biological Process (BP)negative regulation of response to stimulus0.58111InformativeInherited
Biological Process (BP)regulation of catabolic process0.10490.0008207InformativeInherited
Biological Process (BP)regulation of proteolysis0.25950.00003422InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis0.010061InformativeInherited
Biological Process (BP)positive regulation of cellular component organization0.0083990.2197InformativeInherited
Biological Process (BP)positive regulation of developmental process0.010991InformativeInherited
Biological Process (BP)regulation of organelle organization0.0041010.00001279InformativeInherited
Biological Process (BP)vesicle-mediated transport0.13581InformativeInherited
Biological Process (BP)protein folding0.000039760Highly InformativeDirect
Biological Process (BP)regulation of proteolysis involved in cellular protein catabolic process0.00070540.00000006241Highly InformativeDirect
Biological Process (BP)regulation of cellular response to stress0.049120.1603Highly InformativeInherited
Biological Process (BP)regulation of mitochondrion organization0.00000030570.246Highly InformativeInherited
Biological Process (BP)anatomical structure homeostasis0.011790.2615Highly InformativeInherited
Biological Process (BP)Golgi vesicle transport0.0028390.0528Highly InformativeInherited
Biological Process (BP)multicellular organismal homeostasis0.012140.2494Highly InformativeInherited
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)transporter activity11Moderately InformativeInherited
Molecular Function (MF)active transmembrane transporter activity0.58641InformativeInherited
Molecular Function (MF)protein transporter activity0.0000087830.0001875Highly InformativeDirect
Molecular Function (MF)macromolecule transmembrane transporter activity0.00000062430.00000009856Highly InformativeDirect
Molecular Function (MF)amide transmembrane transporter activity0.000039630.0001889Highly InformativeDirect
Molecular Function (MF)chaperone binding0.00017410.0003091Highly InformativeDirect
Cellular Component (CC)intracellular organelle part0.0000055720.00002143Least InformativeDirect
Cellular Component (CC)macromolecular complex0.12410Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.250.5989Least InformativeInherited
Cellular Component (CC)membrane0.31791Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.0040090.05934Least InformativeInherited
Cellular Component (CC)non-membrane-bounded organelle10.01634Least InformativeInherited
Cellular Component (CC)organelle envelope0.30570.2493Moderately InformativeInherited
Cellular Component (CC)membrane protein complex0.000000045220.626Moderately InformativeInherited
Cellular Component (CC)intrinsic component of membrane0.11791Moderately InformativeInherited
Cellular Component (CC)whole membrane0.00000021370.05126Moderately InformativeInherited
Cellular Component (CC)bounding membrane of organelle0.00000034830.03295Moderately InformativeInherited
Cellular Component (CC)mitochondrial part0.71151Moderately InformativeInherited
Cellular Component (CC)endoplasmic reticulum0.00550.1543Moderately InformativeInherited
Cellular Component (CC)vesicle0.98811Moderately InformativeInherited
Cellular Component (CC)cytoskeleton0.15290.1814Moderately InformativeInherited
Cellular Component (CC)outer membrane0.00000019160.000000002165InformativeDirect
Cellular Component (CC)microbody0.00000930.0001809InformativeDirect
Cellular Component (CC)endoplasmic reticulum membrane0.0000096170.2962InformativeInherited
Cellular Component (CC)Golgi apparatus0.45531InformativeInherited
Cellular Component (CC)microtubule cytoskeleton0.0075430.000000002194InformativeInherited
Cellular Component (CC)mitochondrial outer membrane0.0000000015830.000000000003006Highly InformativeDirect
Cellular Component (CC)microtubule organizing center0.00022260.00009051Highly InformativeDirect
Cellular Component (CC)integral component of endoplasmic reticulum membrane0.00000000055970.0002805Highly InformativeDirect
Cellular Component (CC)microbody membrane0.0000006590.00000001538Highly InformativeDirect
Cellular Component (CC)peroxisomal part0.00049570.00001318Highly InformativeDirect
Cellular Component (CC)intrinsic component of organelle membrane0.0041550.2326Highly InformativeInherited
Cellular Component (CC)Golgi-associated vesicle0.00014220.001555Highly InformativeInherited
Cellular Component (CC)coated vesicle0.0019260.3187Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 0.00000000043 Least Informative Direct
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 0.005207 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organelle organization 0 Moderately Informative Direct
Biological Process (BP) cellular component assembly 0.0000003905 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.000000000000001945 Moderately Informative Direct
Biological Process (BP) cellular localization 0 Moderately Informative Direct
Biological Process (BP) organic substance transport 0.0000003196 Moderately Informative Direct
Biological Process (BP) nitrogen compound transport 0.00000000000112 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.3556 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.7222 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.01174 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) system development 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.9782 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.08175 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.9882 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.6143 Moderately Informative Inherited
Biological Process (BP) protein complex biogenesis 0.2343 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.8718 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.001739 Moderately Informative Inherited
Biological Process (BP) gene expression 0.913 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.9874 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) generation of precursor metabolites and energy 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) single organism signaling 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) intracellular protein transport 0.000000000000001945 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0.0006404 Informative Direct
Biological Process (BP) mitochondrion organization 0.0008439 Informative Direct
Biological Process (BP) microtubule-based process 0 Informative Direct
Biological Process (BP) regulation of catabolic process 0.0008207 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0.0002225 Informative Direct
Biological Process (BP) cell cycle process 0.0004029 Informative Direct
Biological Process (BP) regulation of proteolysis 0.00003422 Informative Direct
Biological Process (BP) regulation of organelle organization 0.00001279 Informative Direct
Biological Process (BP) cellular protein complex assembly 0.00000007108 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0.00000001108 Informative Direct
Biological Process (BP) organelle assembly 0.0000000009576 Informative Direct
Biological Process (BP) single-organism intracellular transport 0 Informative Direct
Biological Process (BP) negative regulation of molecular function 0.9078 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.08519 Informative Inherited
Biological Process (BP) regulation of phosphorylation 1 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.2197 Informative Inherited
Biological Process (BP) positive regulation of developmental process 1 Informative Inherited
Biological Process (BP) RNA modification 0.2515 Informative Inherited
Biological Process (BP) protein localization to organelle 0.9466 Informative Inherited
Biological Process (BP) tissue development 1 Informative Inherited
Biological Process (BP) response to radiation 0.7292 Informative Inherited
Biological Process (BP) response to temperature stimulus 0.4832 Informative Inherited
Biological Process (BP) regulation of protein modification process 0.7328 Informative Inherited
Biological Process (BP) regulation of apoptotic process 1 Informative Inherited
Biological Process (BP) regulation of cellular component movement 1 Informative Inherited
Biological Process (BP) cell development 1 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) proteolysis 0.7869 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 1 Informative Inherited
Biological Process (BP) regulation of transferase activity 1 Informative Inherited
Biological Process (BP) organelle localization 1 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) actin filament-based process 0.5046 Informative Inherited
Biological Process (BP) cellular component morphogenesis 1 Informative Inherited
Biological Process (BP) supramolecular fiber organization 0.1919 Informative Inherited
Biological Process (BP) chromosome organization 1 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 1 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 0.4034 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 0.8927 Informative Inherited
Biological Process (BP) cytoskeleton organization 1 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.2347 Informative Inherited
Biological Process (BP) regulation of cellular amide metabolic process 0.6746 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 1 Informative Inherited
Biological Process (BP) positive regulation of gene expression 1 Informative Inherited
Biological Process (BP) DNA metabolic process 1 Informative Inherited
Biological Process (BP) regulation of cell cycle 0.8565 Informative Inherited
Biological Process (BP) transmembrane transport 0.9714 Informative Inherited
Biological Process (BP) single organism reproductive process 0.806 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) embryo development 0.3555 Informative Inherited
Biological Process (BP) post-embryonic development 1 Informative Inherited
Biological Process (BP) reproductive system development 1 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.8588 Informative Inherited
Biological Process (BP) multi-organism reproductive process 0.933 Informative Inherited
Biological Process (BP) locomotion 1 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 1 Informative Inherited
Biological Process (BP) vesicle-mediated transport 1 Informative Inherited
Biological Process (BP) nucleobase-containing compound catabolic process 0.001262 Informative Inherited
Biological Process (BP) sensory organ development 0.1828 Informative Inherited
Biological Process (BP) animal organ morphogenesis 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) ribonucleoprotein complex subunit organization 0.7427 Informative Inherited
Biological Process (BP) negative regulation of gene expression 0.7127 Informative Inherited
Biological Process (BP) RNA catabolic process 0.0005323 Highly Informative Direct
Biological Process (BP) protein folding 0 Highly Informative Direct
Biological Process (BP) microtubule-based movement 0 Highly Informative Direct
Biological Process (BP) protein alkylation 0.00004836 Highly Informative Direct
Biological Process (BP) cell projection assembly 0 Highly Informative Direct
Biological Process (BP) negative regulation of protein modification process 0.0003674 Highly Informative Direct
Biological Process (BP) regulation of chromosome organization 0.000000007588 Highly Informative Direct
Biological Process (BP) macromolecule methylation 0.0002656 Highly Informative Direct
Biological Process (BP) positive regulation of proteolysis 0.00001337 Highly Informative Direct
Biological Process (BP) proteolysis involved in cellular protein catabolic process 0.000007393 Highly Informative Direct
Biological Process (BP) regulation of chromosome segregation 0.00002084 Highly Informative Direct
Biological Process (BP) establishment of protein localization to mitochondrion 0.00001716 Highly Informative Direct
Biological Process (BP) nuclear chromosome segregation 0.00005635 Highly Informative Direct
Biological Process (BP) regulation of proteolysis involved in cellular protein catabolic process 0.00000006241 Highly Informative Direct
Biological Process (BP) regulation of protein modification by small protein conjugation or removal 0.0000000002006 Highly Informative Direct
Biological Process (BP) negative regulation of phosphate metabolic process 1 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.1603 Highly Informative Inherited
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.6974 Highly Informative Inherited
Biological Process (BP) regulation of carbohydrate biosynthetic process 0.0881 Highly Informative Inherited
Biological Process (BP) regulation of mitochondrion organization 0.246 Highly Informative Inherited
Biological Process (BP) kidney development 0.7897 Highly Informative Inherited
Biological Process (BP) demethylation 0.0722 Highly Informative Inherited
Biological Process (BP) cellular response to abiotic stimulus 0.2542 Highly Informative Inherited
Biological Process (BP) protein modification by small protein conjugation 0.003176 Highly Informative Inherited
Biological Process (BP) response to cold 0.5799 Highly Informative Inherited
Biological Process (BP) regulation of microtubule-based process 0.007006 Highly Informative Inherited
Biological Process (BP) vesicle localization 1 Highly Informative Inherited
Biological Process (BP) histone modification 0.7269 Highly Informative Inherited
Biological Process (BP) negative regulation of transferase activity 0.08948 Highly Informative Inherited
Biological Process (BP) anatomical structure homeostasis 0.2615 Highly Informative Inherited
Biological Process (BP) inner ear development 0.004648 Highly Informative Inherited
Biological Process (BP) positive regulation of mitotic cell cycle phase transition 0.002055 Highly Informative Inherited
Biological Process (BP) positive regulation of catabolic process 0.01388 Highly Informative Inherited
Biological Process (BP) cellular component assembly involved in morphogenesis 0.01855 Highly Informative Inherited
Biological Process (BP) actomyosin structure organization 0.009931 Highly Informative Inherited
Biological Process (BP) peptidyl-lysine modification 0.6412 Highly Informative Inherited
Biological Process (BP) neuron development 1 Highly Informative Inherited
Biological Process (BP) plasma membrane bounded cell projection organization 1 Highly Informative Inherited
Biological Process (BP) response to endoplasmic reticulum stress 0.01873 Highly Informative Inherited
Biological Process (BP) microtubule cytoskeleton organization 0.7218 Highly Informative Inherited
Biological Process (BP) mitochondrial respiratory chain complex assembly 0.3562 Highly Informative Inherited
Biological Process (BP) multicellular organism metabolic process 0.001773 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 0.03889 Highly Informative Inherited
Biological Process (BP) pigmentation 0.5235 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 0.8639 Highly Informative Inherited
Biological Process (BP) DNA replication 0.2217 Highly Informative Inherited
Biological Process (BP) regulation of nuclear division 0.3139 Highly Informative Inherited
Biological Process (BP) protein import 0.05764 Highly Informative Inherited
Biological Process (BP) gene silencing 0.009156 Highly Informative Inherited
Biological Process (BP) regulation of gene expression, epigenetic 0.4605 Highly Informative Inherited
Biological Process (BP) seed development 0.06811 Highly Informative Inherited
Biological Process (BP) muscle structure development 0.6686 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.01002 Highly Informative Inherited
Biological Process (BP) epithelial cell differentiation 1 Highly Informative Inherited
Biological Process (BP) germ cell development 0.44 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.3178 Highly Informative Inherited
Biological Process (BP) nuclear division 1 Highly Informative Inherited
Biological Process (BP) Golgi vesicle transport 0.0528 Highly Informative Inherited
Biological Process (BP) mitochondrial transport 0.001586 Highly Informative Inherited
Biological Process (BP) modification-dependent macromolecule catabolic process 0.6764 Highly Informative Inherited
Biological Process (BP) glycoprotein metabolic process 0.05584 Highly Informative Inherited
Biological Process (BP) macromolecule glycosylation 0.001584 Highly Informative Inherited
Biological Process (BP) multicellular organismal homeostasis 0.2494 Highly Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.9895 Highly Informative Inherited
Biological Process (BP) sensory organ morphogenesis 0.1024 Highly Informative Inherited
Biological Process (BP) RNA splicing 0.003339 Highly Informative Inherited
Biological Process (BP) mRNA processing 0.08176 Highly Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 0.2872 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) isomerase activity 0.0005315 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) structural molecule activity 0.8051 Moderately Informative Inherited
Molecular Function (MF) molecular function regulator 1 Moderately Informative Inherited
Molecular Function (MF) nucleotidyltransferase activity 0.00448 Informative Inherited
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) enzyme binding 0.5667 Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring one-carbon groups 0.9271 Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 0.4255 Informative Inherited
Molecular Function (MF) active transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 1 Informative Inherited
Molecular Function (MF) amide binding 0.03365 Informative Inherited
Molecular Function (MF) enzyme inhibitor activity 0.172 Informative Inherited
Molecular Function (MF) macromolecular complex binding 0.01377 Informative Inherited
Molecular Function (MF) protein transporter activity 0.0001875 Highly Informative Direct
Molecular Function (MF) ubiquitin-like protein transferase activity 0.0007415 Highly Informative Direct
Molecular Function (MF) macromolecule transmembrane transporter activity 0.00000009856 Highly Informative Direct
Molecular Function (MF) amide transmembrane transporter activity 0.0001889 Highly Informative Direct
Molecular Function (MF) chaperone binding 0.0003091 Highly Informative Direct
Molecular Function (MF) dioxygenase activity 0.000004392 Highly Informative Direct
Molecular Function (MF) acetyltransferase activity 0.0922 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 0.005904 Highly Informative Inherited
Molecular Function (MF) protein domain specific binding 0.4742 Highly Informative Inherited
Molecular Function (MF) S-adenosylmethionine-dependent methyltransferase activity 0.3734 Highly Informative Inherited
Molecular Function (MF) UDP-glycosyltransferase activity 0.004502 Highly Informative Inherited
Molecular Function (MF) transferase activity, transferring hexosyl groups 0.1036 Highly Informative Inherited
Molecular Function (MF) drug binding 0.00271 Highly Informative Inherited
Molecular Function (MF) GTPase regulator activity 1 Highly Informative Inherited
Molecular Function (MF) protein kinase regulator activity 0.2575 Highly Informative Inherited
Molecular Function (MF) peptide binding 0.009536 Highly Informative Inherited
Cellular Component (CC) macromolecular complex 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.00002143 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.5989 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.01634 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.05934 Least Informative Inherited
Cellular Component (CC) nuclear part 0.0000001539 Moderately Informative Direct
Cellular Component (CC) transferase complex 0.000006951 Moderately Informative Direct
Cellular Component (CC) organelle envelope 0.2493 Moderately Informative Inherited
Cellular Component (CC) membrane protein complex 0.626 Moderately Informative Inherited
Cellular Component (CC) intrinsic component of membrane 1 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.1195 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.1814 Moderately Informative Inherited
Cellular Component (CC) cell projection 0.007834 Moderately Informative Inherited
Cellular Component (CC) whole membrane 0.05126 Moderately Informative Inherited
Cellular Component (CC) bounding membrane of organelle 0.03295 Moderately Informative Inherited
Cellular Component (CC) mitochondrial part 1 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.1543 Moderately Informative Inherited
Cellular Component (CC) vesicle 1 Moderately Informative Inherited
Cellular Component (CC) ubiquitin ligase complex 0.0000000000171 Informative Direct
Cellular Component (CC) cilium 0 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 0.000000002194 Informative Direct
Cellular Component (CC) outer membrane 0.000000002165 Informative Direct
Cellular Component (CC) microbody 0.0001809 Informative Direct
Cellular Component (CC) chromosome 0.0052 Informative Inherited
Cellular Component (CC) plasma membrane bounded cell projection part 0.001369 Informative Inherited
Cellular Component (CC) neuron projection 1 Informative Inherited
Cellular Component (CC) endoplasmic reticulum membrane 0.2962 Informative Inherited
Cellular Component (CC) Golgi apparatus 1 Informative Inherited
Cellular Component (CC) nucleoplasm part 0.8249 Informative Inherited
Cellular Component (CC) transferase complex, transferring phosphorus-containing groups 1 Informative Inherited
Cellular Component (CC) supramolecular polymer 1 Informative Inherited
Cellular Component (CC) nuclear ubiquitin ligase complex 0 Highly Informative Direct
Cellular Component (CC) mitochondrial outer membrane 0.000000000003006 Highly Informative Direct
Cellular Component (CC) microtubule organizing center 0.00009051 Highly Informative Direct
Cellular Component (CC) transcription elongation factor complex 0.000002875 Highly Informative Direct
Cellular Component (CC) CCR4-NOT complex 0.0000001404 Highly Informative Direct
Cellular Component (CC) integral component of endoplasmic reticulum membrane 0.0002805 Highly Informative Direct
Cellular Component (CC) small nuclear ribonucleoprotein complex 0.00004019 Highly Informative Direct
Cellular Component (CC) protein acetyltransferase complex 0.0003041 Highly Informative Direct
Cellular Component (CC) microbody membrane 0.00000001538 Highly Informative Direct
Cellular Component (CC) peroxisomal part 0.00001318 Highly Informative Direct
Cellular Component (CC) nuclear chromosome part 1 Highly Informative Inherited
Cellular Component (CC) chromatin 0.1493 Highly Informative Inherited
Cellular Component (CC) photoreceptor cell cilium 0.1585 Highly Informative Inherited
Cellular Component (CC) intrinsic component of organelle membrane 0.2326 Highly Informative Inherited
Cellular Component (CC) Golgi-associated vesicle 0.001555 Highly Informative Inherited
Cellular Component (CC) coated vesicle 0.3187 Highly Informative Inherited
Cellular Component (CC) myofibril 0.01423 Highly Informative Inherited
Cellular Component (CC) contractile fiber part 0.2265 Highly Informative Inherited
Cellular Component (CC) peptidase complex 0.5961 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Isomerases0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0.5472Least InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases0.003141Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups0.5544Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases0.1413Least InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.0012Moderately InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0.002744Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases0.3264Moderately InformativeInherited
Enzyme Commission (EC)Methyltransferases0.1514Moderately InformativeInherited
Enzyme Commission (EC)Peptidylprolyl isomerase0InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase0.000000000004361InformativeDirect
Enzyme Commission (EC)Phosphoprotein phosphatase0.000000007897InformativeDirect
Enzyme Commission (EC)With 2-oxoglutarate as one donor, and incorporatio0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)genetic disease0.7214Moderately InformativeInherited
Disease Ontology (DO)autosomal recessive disease0.3338InformativeInherited
Disease Ontology (DO)Bardet-Biedl syndrome0.0002688Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the eye0.005595Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.03243Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.04945Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.05705Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.0816Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.09937Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.1884Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the face0.2769Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.5021Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the anterior segment of the globe0.007693Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system morphology0.02245Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of carbohydrate metabolism/homeostasis0.02429Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the skull0.02835Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the oral cavity0.04653Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.05559Moderately InformativeInherited
Phenotypic Abnormality (PA)Aplasia/hypoplasia involving the skeleton0.05962Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal respiratory system morphology0.07429Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of lower limb bone0.07623Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper urinary tract0.09603Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.1093Moderately InformativeInherited
Phenotypic Abnormality (PA)Functional respiratory abnormality0.1691Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of long bone morphology0.1901Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the urinary system physiology0.3784Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digestive system physiology0.4832Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the posterior segment of the globe0.5677Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.6874Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the retina0.004787InformativeInherited
Phenotypic Abnormality (PA)Abnormality of calvarial morphology0.03174InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cranial sutures0.03855InformativeInherited
Phenotypic Abnormality (PA)Abnormality of vision0.09543InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the pancreas0.1577InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lens0.1604InformativeInherited
Phenotypic Abnormality (PA)Abnormality of dental eruption0.2677InformativeInherited
Phenotypic Abnormality (PA)Renal insufficiency0.295InformativeInherited
Phenotypic Abnormality (PA)Aplasia/hypoplasia involving bones of the lower limbs0.4313InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia affecting the eye0.4882InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the hip bone0.7168InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cerebellum0.8704InformativeInherited
Phenotypic Abnormality (PA)Tubulointerstitial nephritis0.000009792Highly InformativeDirect
Phenotypic Abnormality (PA)Hepatic failure0.00001951Highly InformativeDirect
Phenotypic Abnormality (PA)Stage 5 chronic kidney disease0.00003562Highly InformativeDirect
Phenotypic Abnormality (PA)Pancreatic fibrosis0.00006618Highly InformativeDirect
Phenotypic Abnormality (PA)Unicoronal synostosis0.00008911Highly InformativeDirect
Phenotypic Abnormality (PA)Pigmentary retinopathy0.0001639Highly InformativeDirect
Phenotypic Abnormality (PA)Natal tooth0.000181Highly InformativeDirect
Phenotypic Abnormality (PA)Hepatic fibrosis0.0002192Highly InformativeDirect
Phenotypic Abnormality (PA)Metaphyseal spurs0.0003172Highly InformativeDirect
Phenotypic Abnormality (PA)Absent tibia0.0003172Highly InformativeDirect
Phenotypic Abnormality (PA)Nephronophthisis0.0003429Highly InformativeDirect
Phenotypic Abnormality (PA)Glucose intolerance0.0003429Highly InformativeDirect
Phenotypic Abnormality (PA)Cerebellar vermis hypoplasia0.0003819Highly InformativeDirect
Phenotypic Abnormality (PA)Congenital primary aphakia0.0005092Highly InformativeDirect
Phenotypic Abnormality (PA)Respiratory distress0.0005301Highly InformativeDirect
Phenotypic Abnormality (PA)Situs inversus totalis0.0005373Highly InformativeDirect
Phenotypic Abnormality (PA)Pulmonary hypoplasia0.0005681Highly InformativeDirect
Phenotypic Abnormality (PA)Nephrogenic diabetes insipidus0.000769Highly InformativeDirect
Phenotypic Abnormality (PA)Hypoplastic ilia0.01491Highly InformativeInherited
Phenotypic Abnormality (PA)Blindness0.1335Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.1063Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal kidney epithelium morphology0.0009197Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organ system morphology variant0.00000003035Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.00000008893Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0.0008719Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.01877Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.03664Least InformativeInherited
Worm Phenotype (WP)cell development variant0.04412Least InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.0001199Moderately InformativeDirect
Worm Phenotype (WP)chemical response variant0.01531Moderately InformativeInherited
Worm Phenotype (WP)gametogenesis variant0.04897Moderately InformativeInherited
Worm Phenotype (WP)nervous system morphology variant0.07897Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.122Moderately InformativeInherited
Worm Phenotype (WP)cell component morphology variant0.4284Moderately InformativeInherited
Worm Phenotype (WP)sensillum morphology variant0.000000008992InformativeDirect
Worm Phenotype (WP)chemotaxis variant0.0002484InformativeDirect
Worm Phenotype (WP)male morphology variant0.0003873InformativeDirect
Worm Phenotype (WP)embryonic cell organization biogenesis variant0.001154InformativeInherited
Worm Phenotype (WP)dauer arrest variant0.007966InformativeInherited
Worm Phenotype (WP)sexually dimorphic behavior variant0.02735InformativeInherited
Worm Phenotype (WP)mitotic spindle defective early emb0.0001103Highly InformativeDirect
Worm Phenotype (WP)dauer development variant0.0004313Highly InformativeDirect
Worm Phenotype (WP)cell cycle variant0.04519Highly InformativeInherited
Worm Phenotype (WP)osmotic avoidance variant0.1223Highly InformativeInherited
Worm Phenotype (WP)touch resistant0.309Highly InformativeInherited

Document: WP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)embryonic structure0.05339Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)gonad0.009196Least InformativeInherited
Xenopus ANatomical entity (XAN)genital system0.06388Least InformativeInherited
Xenopus ANatomical entity (XAN)female genitalia0.0008204Moderately InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)seed0.00000001355Least InformativeDirect
Plant ANatomical entity (PAN)whole plant0.04216Least InformativeInherited
Plant ANatomical entity (PAN)shoot axis0.1746Least InformativeInherited
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0.00004498Least InformativeDirect
Plant structure DEvelopment stage (PDE)0 seed germination stage0InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0.0007807Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases0.1618Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Isomerases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.0003156Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.001384Moderately InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases0.006004Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases0.5215Moderately InformativeInherited
Enzyme Commission (EC)Acyltransferases0.5463Moderately InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups0.7041Moderately InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase0.000000000003256InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0.000001086InformativeDirect
Enzyme Commission (EC)RING-type E3 ubiquitin transferase0.000006672InformativeDirect
Enzyme Commission (EC)Hexosyltransferases0.009251InformativeInherited
Enzyme Commission (EC)Phosphorus-oxygen lyases1InformativeInherited
Enzyme Commission (EC)With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors0Highly InformativeDirect
Enzyme Commission (EC)Peptidylprolyl isomerase0Highly InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine phosphatase0.0000000003403Highly InformativeDirect
Enzyme Commission (EC)Adenylate cyclase0.0000007947Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processProtein transport0Moderately InformativeDirect
Biological processUbl conjugation pathway0Moderately InformativeDirect
Biological processDifferentiation0.00000000007193Moderately InformativeDirect
Biological processCell cycle0.00000004482Moderately InformativeDirect
Biological processApoptosis0.00008698Moderately InformativeDirect
Biological processImmunity0.006963Moderately InformativeInherited
Biological processMitosis0InformativeDirect
Biological processmRNA processing0InformativeDirect
Biological processPhotosynthesis0InformativeDirect
Biological processMeiosis0.000000000019InformativeDirect
Biological processNeurogenesis0.0000008403InformativeDirect
Biological processInnate immunity0.00001189InformativeDirect
Biological processER-Golgi transport0Highly InformativeDirect
Biological processCilium biogenesis/degradation0Highly InformativeDirect
Biological processRNA-mediated gene silencing0.000000000005311Highly InformativeDirect
Biological processChromosome partition0.000000002124Highly InformativeDirect
Biological processMyogenesis0.000000004736Highly InformativeDirect
Biological processNonsense-mediated mRNA decay0.0000002564Highly InformativeDirect
Biological processAntiviral defense0.000000794Highly InformativeDirect
Biological processUnfolded protein response0.000005913Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentPlastid0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentMitochondrion0.00000000000009103Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0.000008569Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.0001441Moderately InformativeDirect
Cellular componentMicrotubule0InformativeDirect
Cellular componentSpliceosome0InformativeDirect
Cellular componentThylakoid0InformativeDirect
Cellular componentCilium0InformativeDirect
Cellular componentMitochondrion outer membrane0InformativeDirect
Cellular componentPeroxisome0.000000000002048InformativeDirect
Cellular componentCell outer membrane0.000003948InformativeDirect
Cellular componentProteasome0.00005632Highly InformativeDirect
Coding sequence diversityAlternative splicing0.0001659Least InformativeDirect
DiseaseCiliopathy0.000000007616InformativeDirect
DomainRepeat0Least InformativeDirect
DomainTPR repeat0Highly InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationActivator0.0000008194Moderately InformativeDirect
Post-translational modificationDevelopmental protein0.0001271Moderately InformativeDirect
Post-translational modificationIsomerase0.8821Moderately InformativeInherited
Post-translational modificationOxidoreductase1Moderately InformativeInherited
Post-translational modificationChaperone0.000000004499InformativeDirect
Post-translational modificationProtein phosphatase0.0000001717InformativeDirect
Post-translational modificationChromatin regulator0.00000925InformativeDirect
Post-translational modificationInitiation factor0.00001054InformativeDirect
Post-translational modificationRotamase0Highly InformativeDirect
Post-translational modificationDioxygenase0.0000000000001442Highly InformativeDirect
Post-translational modificationAcetylation0Least InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation0.000000000004729Moderately InformativeDirect
Post-translational modificationIsopeptide bond0.000000007719Moderately InformativeDirect
Post-translational modificationPalmitate0.0008467Moderately InformativeDirect
Post-translational modificationThioester bond0Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)glycan metabolism0.0000002377Moderately InformativeDirect
UniPathway (UP)protein ubiquitination0.0003683Moderately InformativeDirect
UniPathway (UP)cellulose metabolism0.000000000003088InformativeDirect
UniPathway (UP)cellulose biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 29 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a TPR-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 29 hidden Markov models representing the TPR-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]