SUPERFAMILY 1.75 HMM library and genome assignments server

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TPR-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   alpha-alpha superhelix [ 48370] (24)
Superfamily:   TPR-like [ 48452] (8)
Families:   Tetratricopeptide repeat (TPR) [ 48453] (17)
  Transcription factor MalT domain III [ 69094]
  BTAD-like [ 140845]
  PrgX C-terminal domain-like [ 140848]
  Atu0120-like [ 158772]
  SusD-like [ 158775] (3)
  HAT/Suf repeat [ 158782]
  CT2138-like [ 158785]


Superfamily statistics
Genomes (3,133) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 169,526 955,257 50
Proteins 125,432 730,800 49


Functional annotation
General category General
Detailed category Protein interaction

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Isomerases0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0.5472Least InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases0.003141Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups0.5544Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases0.1413Least InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.0012Moderately InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0.002744Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases0.3264Moderately InformativeInherited
Enzyme Commission (EC)Methyltransferases0.1514Moderately InformativeInherited
Enzyme Commission (EC)Peptidylprolyl isomerase0InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase0.000000000004361InformativeDirect
Enzyme Commission (EC)Phosphoprotein phosphatase0.000000007897InformativeDirect
Enzyme Commission (EC)With 2-oxoglutarate as one donor, and incorporatio0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)genetic disease0.7219Moderately InformativeInherited
Disease Ontology (DO)autosomal recessive disease0.3353InformativeInherited
Disease Ontology (DO)Bardet-Biedl syndrome0.0002735Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the eye0.0005488Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.3412Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.5612Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.1235Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper urinary tract0.5296Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal renal morphology0.1953InformativeInherited
Phenotypic Abnormality (PA)Nephronophthisis0.0004014Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.1092Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal kidney epithelium morphology0.0009104Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organ system morphology variant0.0000000794Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.0000008284Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0.000004634Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.0006952Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.01935Least InformativeInherited
Worm Phenotype (WP)cell development variant0.03652Least InformativeInherited
Worm Phenotype (WP)larval development variant0.3195Least InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.000009708Moderately InformativeDirect
Worm Phenotype (WP)germ cell development variant0.002544Moderately InformativeInherited
Worm Phenotype (WP)drug response variant0.00952Moderately InformativeInherited
Worm Phenotype (WP)cell cycle variant0.04723Moderately InformativeInherited
Worm Phenotype (WP)nervous system morphology variant0.1497Moderately InformativeInherited
Worm Phenotype (WP)cell organization biogenesis variant0.1672Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.2145Moderately InformativeInherited
Worm Phenotype (WP)reproductive system development variant0.4371Moderately InformativeInherited
Worm Phenotype (WP)sensillum morphology variant0.00000003819InformativeDirect
Worm Phenotype (WP)embryonic cell organization biogenesis variant0.0000656InformativeDirect
Worm Phenotype (WP)male morphology variant0.0000964InformativeDirect
Worm Phenotype (WP)somatic gonad development variant0.0001013InformativeDirect
Worm Phenotype (WP)male gonad development variant0.0003278InformativeDirect
Worm Phenotype (WP)chemotaxis variant0.0009304InformativeDirect
Worm Phenotype (WP)pesticide response variant0.002723InformativeInherited
Worm Phenotype (WP)drug resistant0.004093InformativeInherited
Worm Phenotype (WP)chemical resistant0.004213InformativeInherited
Worm Phenotype (WP)cytoskeleton organization biogenesis variant0.005485InformativeInherited
Worm Phenotype (WP)mechanosensation variant0.02745InformativeInherited
Worm Phenotype (WP)neuron morphology variant0.4781InformativeInherited
Worm Phenotype (WP)dauer larva physiology variant1InformativeInherited
Worm Phenotype (WP)mitotic spindle defective early emb0.000002401Highly InformativeDirect
Worm Phenotype (WP)antihelmintic response variant0.000008712Highly InformativeDirect
Worm Phenotype (WP)dye filling defect0.000008968Highly InformativeDirect
Worm Phenotype (WP)pronucleus centrosomes defective early emb0.0002379Highly InformativeDirect
Worm Phenotype (WP)nuclear number variant0.0004156Highly InformativeDirect
Worm Phenotype (WP)dauer development variant0.0008189Highly InformativeDirect
Worm Phenotype (WP)touch resistant0.2331Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)nervous system0.7398Least InformativeInherited
Fly Anatomy (FA)organism subdivision0.9579Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.9695Least InformativeInherited
Fly Anatomy (FA)adult0.9718Least InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.2109Moderately InformativeInherited
Fly Anatomy (FA)adult segment0.9504Moderately InformativeInherited
Fly Anatomy (FA)head0.9599Moderately InformativeInherited
Fly Anatomy (FA)adult tagma1Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system1Moderately InformativeInherited
Fly Anatomy (FA)nerve0.1948InformativeInherited
Fly Anatomy (FA)adult procephalic segment0.8785InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)seed0.00000001357Least InformativeDirect
Plant ANatomical entity (PAN)whole plant0.04222Least InformativeInherited
Plant ANatomical entity (PAN)shoot axis0.1747Least InformativeInherited
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0.00004502Least InformativeDirect
Plant structure DEvelopment stage (PDE)0 seed germination stage0InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0.009254Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases0.3981Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Isomerases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0.00000001513Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.0000002613Moderately InformativeDirect
Enzyme Commission (EC)Aminoacyltransferases0.0003736Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.001105Moderately InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases0.06452Moderately InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Moderately InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0InformativeDirect
Enzyme Commission (EC)Hexosyltransferases0InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0.0000000000007194InformativeDirect
Enzyme Commission (EC)RING-type E3 ubiquitin transferase0.000004521InformativeDirect
Enzyme Commission (EC)Phosphorus-oxygen lyases1InformativeInherited
Enzyme Commission (EC)With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors0Highly InformativeDirect
Enzyme Commission (EC)Peptidylprolyl isomerase0Highly InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine phosphatase0.000000001716Highly InformativeDirect
Enzyme Commission (EC)Adenylate cyclase0.000001656Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 51 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a TPR-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 51 hidden Markov models representing the TPR-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]