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TPR-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   alpha-alpha superhelix [ 48370] (24)
Superfamily:   TPR-like [ 48452] (8)
Families:   Tetratricopeptide repeat (TPR) [ 48453] (17)
  Transcription factor MalT domain III [ 69094]
  BTAD-like [ 140845]
  PrgX C-terminal domain-like [ 140848]
  Atu0120-like [ 158772]
  SusD-like [ 158775] (3)
  HAT/Suf repeat [ 158782]
  CT2138-like [ 158785]


Superfamily statistics
Genomes (3,126) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 167,029 406,918 50
Proteins 123,775 317,615 49


Functional annotation
General category General
Detailed category Protein interaction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular component organization or biogenesis0.00019090.00000000008335Least InformativeDirect
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)biological regulation11Least InformativeInherited
Biological Process (BP)regulation of cellular component organization0.10561Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process11Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.38881Moderately InformativeInherited
Biological Process (BP)regulation of biological quality11Moderately InformativeInherited
Biological Process (BP)generation of precursor metabolites and energy0.52031Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.0025880.00000000000001068Moderately InformativeInherited
Biological Process (BP)organic substance transport0.36650.000004838Moderately InformativeInherited
Biological Process (BP)organelle organization0.43440.000000000000003692Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular component organization0.00580.2719InformativeInherited
Biological Process (BP)positive regulation of developmental process0.0096561InformativeInherited
Biological Process (BP)regulation of organelle organization0.0012770.043InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis0.01151InformativeInherited
Biological Process (BP)organelle fission0.00051130.01353InformativeInherited
Biological Process (BP)vesicle-mediated transport0.023711InformativeInherited
Biological Process (BP)protein folding0.000034390Highly InformativeDirect
Biological Process (BP)regulation of mitochondrion organization0.0000027210.1261Highly InformativeInherited
Biological Process (BP)positive regulation of organelle organization0.000015930.001036Highly InformativeInherited
Biological Process (BP)anatomical structure homeostasis0.010990.1028Highly InformativeInherited
Biological Process (BP)cell projection organization0.047960.00000004501Highly InformativeInherited
Biological Process (BP)Golgi vesicle transport0.011890.08962Highly InformativeInherited
Biological Process (BP)multicellular organismal homeostasis0.011660.1833Highly InformativeInherited
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)protein binding0.14710.003273Moderately InformativeInherited
Molecular Function (MF)transporter activity11Moderately InformativeInherited
Molecular Function (MF)active transmembrane transporter activity0.79751InformativeInherited
Molecular Function (MF)macromolecule transmembrane transporter activity0.000016440.000000972Highly InformativeDirect
Molecular Function (MF)protein transporter activity0.000093030.0004635Highly InformativeDirect
Molecular Function (MF)chaperone binding0.00013980.00003543Highly InformativeDirect
Cellular Component (CC)protein complex0.0000012050.0001261Least InformativeDirect
Cellular Component (CC)intracellular organelle part0.0000018230.0000001852Least InformativeDirect
Cellular Component (CC)membrane0.25851Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.30430.5638Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.24520.7507Least InformativeInherited
Cellular Component (CC)membrane protein complex0.00000019440.3637Moderately InformativeInherited
Cellular Component (CC)whole membrane0.00000025720.08873Moderately InformativeInherited
Cellular Component (CC)mitochondrial part0.76891Moderately InformativeInherited
Cellular Component (CC)endoplasmic reticulum0.006170.3299Moderately InformativeInherited
Cellular Component (CC)intrinsic component of membrane0.11531Moderately InformativeInherited
Cellular Component (CC)vesicle0.95461Moderately InformativeInherited
Cellular Component (CC)organelle membrane0.0093340.5849Moderately InformativeInherited
Cellular Component (CC)organelle envelope0.40770.503Moderately InformativeInherited
Cellular Component (CC)outer membrane0.0000006850.000000006404InformativeDirect
Cellular Component (CC)microbody0.0000050060.0002105InformativeDirect
Cellular Component (CC)endoplasmic reticulum membrane0.0000081250.1874InformativeInherited
Cellular Component (CC)Golgi apparatus0.3961InformativeInherited
Cellular Component (CC)integral component of endoplasmic reticulum membrane0.00000000023170.0002615Highly InformativeDirect
Cellular Component (CC)mitochondrial outer membrane0.00000001890.00000000003463Highly InformativeDirect
Cellular Component (CC)microbody membrane0.00000078520.00000002756Highly InformativeDirect
Cellular Component (CC)peroxisomal part0.00067730.00002581Highly InformativeDirect
Cellular Component (CC)Golgi-associated vesicle0.00014520.004933Highly InformativeInherited
Cellular Component (CC)coated vesicle0.0015690.4116Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 0.00000000008335 Least Informative Direct
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 0.06581 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) macromolecule localization 0.00000000000001068 Moderately Informative Direct
Biological Process (BP) cellular localization 0.00000000000001068 Moderately Informative Direct
Biological Process (BP) cellular component assembly 0.0004238 Moderately Informative Direct
Biological Process (BP) organic substance transport 0.000004838 Moderately Informative Direct
Biological Process (BP) organelle organization 0.000000000000003692 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 0.6996 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.8707 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) system development 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.8558 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.2445 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to stress 1 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) gene expression 0.9825 Moderately Informative Inherited
Biological Process (BP) generation of precursor metabolites and energy 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.0188 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) signaling 1 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative biosynthetic process 0.8587 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.7112 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.008072 Moderately Informative Inherited
Biological Process (BP) single-organism intracellular transport 0 Informative Direct
Biological Process (BP) cellular macromolecular complex assembly 0.000002358 Informative Direct
Biological Process (BP) cell cycle process 0.00003563 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0.00008967 Informative Direct
Biological Process (BP) microtubule-based process 0 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0.0000001359 Informative Direct
Biological Process (BP) organelle assembly 0.000000368 Informative Direct
Biological Process (BP) regulation of proteolysis 0.00004818 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0.0001433 Informative Direct
Biological Process (BP) regulation of catabolic process 0.0004255 Informative Direct
Biological Process (BP) regulation of protein modification process 0.7895 Informative Inherited
Biological Process (BP) negative regulation of molecular function 0.6808 Informative Inherited
Biological Process (BP) negative regulation of cellular protein metabolic process 0.1042 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) regulation of phosphorylation 1 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 0.892 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 1 Informative Inherited
Biological Process (BP) positive regulation of developmental process 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) protein localization to organelle 1 Informative Inherited
Biological Process (BP) epithelium development 0.9433 Informative Inherited
Biological Process (BP) response to radiation 0.6227 Informative Inherited
Biological Process (BP) response to temperature stimulus 0.5215 Informative Inherited
Biological Process (BP) regulation of apoptotic process 1 Informative Inherited
Biological Process (BP) cell development 1 Informative Inherited
Biological Process (BP) proteolysis 1 Informative Inherited
Biological Process (BP) regulation of transferase activity 1 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 1 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) regulation of cell cycle 0.6728 Informative Inherited
Biological Process (BP) cytoskeleton organization 1 Informative Inherited
Biological Process (BP) actin filament-based process 0.6021 Informative Inherited
Biological Process (BP) cellular component morphogenesis 1 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 0.4571 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 1 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) positive regulation of gene expression 1 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 1 Informative Inherited
Biological Process (BP) mitochondrion organization 0.4408 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.8935 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) regulation of cellular amide metabolic process 0.6391 Informative Inherited
Biological Process (BP) DNA metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.2719 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.043 Informative Inherited
Biological Process (BP) organelle fission 0.01353 Informative Inherited
Biological Process (BP) transmembrane transport 1 Informative Inherited
Biological Process (BP) negative regulation of gene expression 1 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) multicellular organism reproduction 1 Informative Inherited
Biological Process (BP) multi-organism reproductive process 1 Informative Inherited
Biological Process (BP) locomotion 1 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 1 Informative Inherited
Biological Process (BP) vesicle-mediated transport 1 Informative Inherited
Biological Process (BP) protein targeting 1 Informative Inherited
Biological Process (BP) embryo development 0.2603 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) nucleobase-containing compound catabolic process 0.002057 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.1047 Informative Inherited
Biological Process (BP) protein folding 0 Highly Informative Direct
Biological Process (BP) protein localization to mitochondrion 0.00002322 Highly Informative Direct
Biological Process (BP) mitochondrial transport 0.00000001812 Highly Informative Direct
Biological Process (BP) cell projection organization 0.00000004501 Highly Informative Direct
Biological Process (BP) microtubule-based movement 0 Highly Informative Direct
Biological Process (BP) mRNA metabolic process 0.00000000004239 Highly Informative Direct
Biological Process (BP) regulation of protein modification by small protein conjugation or removal 0.00000000203 Highly Informative Direct
Biological Process (BP) regulation of chromosome organization 0.00000002196 Highly Informative Direct
Biological Process (BP) positive regulation of proteolysis 0.00002461 Highly Informative Direct
Biological Process (BP) regulation of protein catabolic process 0.00003128 Highly Informative Direct
Biological Process (BP) macromolecule methylation 0.00005244 Highly Informative Direct
Biological Process (BP) RNA catabolic process 0.0002582 Highly Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0.0002698 Highly Informative Direct
Biological Process (BP) regulation of mitotic cell cycle phase transition 0.0003704 Highly Informative Direct
Biological Process (BP) positive regulation of mitotic cell cycle 0.0006747 Highly Informative Direct
Biological Process (BP) protein modification by small protein conjugation 0.0008038 Highly Informative Direct
Biological Process (BP) negative regulation of protein modification process 0.00461 Highly Informative Inherited
Biological Process (BP) negative regulation of transferase activity 0.04983 Highly Informative Inherited
Biological Process (BP) negative regulation of phosphate metabolic process 0.948 Highly Informative Inherited
Biological Process (BP) positive regulation of catabolic process 0.01552 Highly Informative Inherited
Biological Process (BP) positive regulation of cell cycle process 0.02941 Highly Informative Inherited
Biological Process (BP) regulation of nuclear division 0.002829 Highly Informative Inherited
Biological Process (BP) regulation of carbohydrate biosynthetic process 0.1672 Highly Informative Inherited
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.8331 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.001036 Highly Informative Inherited
Biological Process (BP) regulation of mitochondrion organization 0.1261 Highly Informative Inherited
Biological Process (BP) histone modification 0.6141 Highly Informative Inherited
Biological Process (BP) demethylation 0.06653 Highly Informative Inherited
Biological Process (BP) cellular response to abiotic stimulus 0.2241 Highly Informative Inherited
Biological Process (BP) response to cold 0.7042 Highly Informative Inherited
Biological Process (BP) microtubule cytoskeleton organization 1 Highly Informative Inherited
Biological Process (BP) inner ear development 0.004068 Highly Informative Inherited
Biological Process (BP) neuron development 1 Highly Informative Inherited
Biological Process (BP) pigmentation 0.4791 Highly Informative Inherited
Biological Process (BP) multicellular organismal homeostasis 0.1833 Highly Informative Inherited
Biological Process (BP) anatomical structure homeostasis 0.1028 Highly Informative Inherited
Biological Process (BP) actomyosin structure organization 0.009411 Highly Informative Inherited
Biological Process (BP) cellular component assembly involved in morphogenesis 0.01859 Highly Informative Inherited
Biological Process (BP) multicellular organism metabolic process 0.00134 Highly Informative Inherited
Biological Process (BP) peptidyl-lysine modification 0.6232 Highly Informative Inherited
Biological Process (BP) internal protein amino acid acetylation 1 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.3269 Highly Informative Inherited
Biological Process (BP) appendage development 1 Highly Informative Inherited
Biological Process (BP) response to endoplasmic reticulum stress 0.2594 Highly Informative Inherited
Biological Process (BP) mitochondrial respiratory chain complex assembly 0.193 Highly Informative Inherited
Biological Process (BP) chromosome organization 1 Highly Informative Inherited
Biological Process (BP) sensory organ morphogenesis 0.08719 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 0.001855 Highly Informative Inherited
Biological Process (BP) establishment of organelle localization 0.08702 Highly Informative Inherited
Biological Process (BP) vesicle localization 1 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 0.9869 Highly Informative Inherited
Biological Process (BP) DNA replication 0.3024 Highly Informative Inherited
Biological Process (BP) modification-dependent protein catabolic process 0.04491 Highly Informative Inherited
Biological Process (BP) proteasomal protein catabolic process 0.5166 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.004228 Highly Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.5752 Highly Informative Inherited
Biological Process (BP) protein import 0.1611 Highly Informative Inherited
Biological Process (BP) gene silencing 0.006131 Highly Informative Inherited
Biological Process (BP) regulation of gene expression, epigenetic 0.6405 Highly Informative Inherited
Biological Process (BP) muscle structure development 0.6438 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.5373 Highly Informative Inherited
Biological Process (BP) germ cell development 0.5369 Highly Informative Inherited
Biological Process (BP) epithelial cell differentiation 0.9332 Highly Informative Inherited
Biological Process (BP) cell migration 0.9545 Highly Informative Inherited
Biological Process (BP) mitotic nuclear division 0.007707 Highly Informative Inherited
Biological Process (BP) nuclear chromosome segregation 0.001519 Highly Informative Inherited
Biological Process (BP) Golgi vesicle transport 0.08962 Highly Informative Inherited
Biological Process (BP) glycoprotein metabolic process 0.02991 Highly Informative Inherited
Biological Process (BP) macromolecule glycosylation 0.001572 Highly Informative Inherited
Biological Process (BP) RNA splicing 0.003082 Highly Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 0.3879 Highly Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) isomerase activity 0.0004619 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) protein binding 0.003273 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) structural molecule activity 0.6849 Moderately Informative Inherited
Molecular Function (MF) molecular function regulator 1 Moderately Informative Inherited
Molecular Function (MF) nucleotidyltransferase activity 0.004674 Informative Inherited
Molecular Function (MF) transferase activity, transferring one-carbon groups 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 1 Informative Inherited
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 1 Informative Inherited
Molecular Function (MF) active transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 0.4276 Informative Inherited
Molecular Function (MF) enzyme inhibitor activity 0.1567 Informative Inherited
Molecular Function (MF) enzyme binding 0.4428 Informative Inherited
Molecular Function (MF) macromolecular complex binding 0.9204 Informative Inherited
Molecular Function (MF) amide binding 0.0442 Informative Inherited
Molecular Function (MF) macromolecule transmembrane transporter activity 0.000000972 Highly Informative Direct
Molecular Function (MF) protein transporter activity 0.0004635 Highly Informative Direct
Molecular Function (MF) chaperone binding 0.00003543 Highly Informative Direct
Molecular Function (MF) dioxygenase activity 0.000003142 Highly Informative Direct
Molecular Function (MF) ubiquitin-like protein transferase activity 0.0005475 Highly Informative Direct
Molecular Function (MF) acetyltransferase activity 0.07418 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 0.005853 Highly Informative Inherited
Molecular Function (MF) S-adenosylmethionine-dependent methyltransferase activity 0.7286 Highly Informative Inherited
Molecular Function (MF) transferase activity, transferring hexosyl groups 0.1022 Highly Informative Inherited
Molecular Function (MF) UDP-glycosyltransferase activity 0.004061 Highly Informative Inherited
Molecular Function (MF) drug binding 0.002661 Highly Informative Inherited
Molecular Function (MF) GTPase regulator activity 1 Highly Informative Inherited
Molecular Function (MF) protein kinase regulator activity 0.2384 Highly Informative Inherited
Molecular Function (MF) peptide binding 0.01492 Highly Informative Inherited
Cellular Component (CC) protein complex 0.0001261 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.0000001852 Least Informative Direct
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.002251 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.5638 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.7507 Least Informative Inherited
Cellular Component (CC) nuclear part 0.00000001188 Moderately Informative Direct
Cellular Component (CC) transferase complex 0.0000677 Moderately Informative Direct
Cellular Component (CC) membrane protein complex 0.3637 Moderately Informative Inherited
Cellular Component (CC) whole membrane 0.08873 Moderately Informative Inherited
Cellular Component (CC) mitochondrial part 1 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.1307 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.009608 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.3299 Moderately Informative Inherited
Cellular Component (CC) intrinsic component of membrane 1 Moderately Informative Inherited
Cellular Component (CC) vesicle 1 Moderately Informative Inherited
Cellular Component (CC) cell projection 0.003473 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.5849 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 0.503 Moderately Informative Inherited
Cellular Component (CC) outer membrane 0.000000006404 Informative Direct
Cellular Component (CC) microbody 0.0002105 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 0.000000006151 Informative Direct
Cellular Component (CC) cell projection part 0.000002398 Informative Direct
Cellular Component (CC) cilium 0 Informative Direct
Cellular Component (CC) ubiquitin ligase complex 0.000000000008412 Informative Direct
Cellular Component (CC) chromosome 0.00006175 Informative Direct
Cellular Component (CC) endoplasmic reticulum membrane 0.1874 Informative Inherited
Cellular Component (CC) nucleoplasm part 0.6475 Informative Inherited
Cellular Component (CC) Golgi apparatus 1 Informative Inherited
Cellular Component (CC) DNA-directed RNA polymerase complex 0.1381 Informative Inherited
Cellular Component (CC) integral component of endoplasmic reticulum membrane 0.0002615 Highly Informative Direct
Cellular Component (CC) mitochondrial outer membrane 0.00000000003463 Highly Informative Direct
Cellular Component (CC) microbody membrane 0.00000002756 Highly Informative Direct
Cellular Component (CC) peroxisomal part 0.00002581 Highly Informative Direct
Cellular Component (CC) nuclear ubiquitin ligase complex 0 Highly Informative Direct
Cellular Component (CC) transcription elongation factor complex 0.000003616 Highly Informative Direct
Cellular Component (CC) small nuclear ribonucleoprotein complex 0.00007155 Highly Informative Direct
Cellular Component (CC) protein acetyltransferase complex 0.0008299 Highly Informative Direct
Cellular Component (CC) nuclear chromosome 0.5982 Highly Informative Inherited
Cellular Component (CC) chromatin 0.02043 Highly Informative Inherited
Cellular Component (CC) 9+2 non-motile cilium 1 Highly Informative Inherited
Cellular Component (CC) myofibril 0.01312 Highly Informative Inherited
Cellular Component (CC) Golgi-associated vesicle 0.004933 Highly Informative Inherited
Cellular Component (CC) coated vesicle 0.4116 Highly Informative Inherited
Cellular Component (CC) contractile fiber part 0.2219 Highly Informative Inherited
Cellular Component (CC) peptidase complex 0.2362 Highly Informative Inherited
Cellular Component (CC) polymeric cytoskeletal fiber 1 Highly Informative Inherited
Cellular Component (CC) condensed chromosome 0.5394 Highly Informative Inherited
Cellular Component (CC) centrosome 0.2631 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Isomerases0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0.5472Least InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases0.003141Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups0.5544Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases0.1413Least InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.0012Moderately InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0.002744Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases0.3264Moderately InformativeInherited
Enzyme Commission (EC)Methyltransferases0.1514Moderately InformativeInherited
Enzyme Commission (EC)Peptidylprolyl isomerase0InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase0.000000000004361InformativeDirect
Enzyme Commission (EC)Phosphoprotein phosphatase0.000000007897InformativeDirect
Enzyme Commission (EC)With 2-oxoglutarate as one donor, and incorporatio0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)genetic disease0.7313Moderately InformativeInherited
Disease Ontology (DO)autosomal recessive disease0.3477InformativeInherited
Disease Ontology (DO)Bardet-Biedl syndrome0.0002789Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the eye0.00551Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.03258Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.04006Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.05426Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.08001Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.102Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.1856Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the face0.2771Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.4983Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the anterior segment of the globe0.009309Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of carbohydrate metabolism/homeostasis0.02437Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the skull0.02801Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system morphology0.02875Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the oral cavity0.04669Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.05585Moderately InformativeInherited
Phenotypic Abnormality (PA)Aplasia/hypoplasia involving the skeleton0.06022Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal respiratory system morphology0.06267Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of lower limb bone0.07589Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper urinary tract0.09173Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.1302Moderately InformativeInherited
Phenotypic Abnormality (PA)Functional respiratory abnormality0.1809Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of long bone morphology0.1913Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the urinary system physiology0.3845Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the posterior segment of the globe0.605Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.6868Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the retina0.005119InformativeInherited
Phenotypic Abnormality (PA)Abnormality of calvarial morphology0.03162InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cranial sutures0.03872InformativeInherited
Phenotypic Abnormality (PA)Cerebellar malformation0.07763InformativeInherited
Phenotypic Abnormality (PA)Abnormality of vision0.0995InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the pancreas0.1501InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lens0.163InformativeInherited
Phenotypic Abnormality (PA)Respiratory insufficiency0.204InformativeInherited
Phenotypic Abnormality (PA)Abnormality of dental eruption0.2729InformativeInherited
Phenotypic Abnormality (PA)Renal insufficiency0.2999InformativeInherited
Phenotypic Abnormality (PA)Aplasia/hypoplasia involving bones of the lower limbs0.4307InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia affecting the eye0.5075InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the hip bone0.7121InformativeInherited
Phenotypic Abnormality (PA)Tubulointerstitial nephritis0.00001035Highly InformativeDirect
Phenotypic Abnormality (PA)Hepatic failure0.00001861Highly InformativeDirect
Phenotypic Abnormality (PA)Stage 5 chronic kidney disease0.00003862Highly InformativeDirect
Phenotypic Abnormality (PA)Pancreatic fibrosis0.00006887Highly InformativeDirect
Phenotypic Abnormality (PA)Unicoronal synostosis0.00009207Highly InformativeDirect
Phenotypic Abnormality (PA)Pigmentary retinopathy0.0001819Highly InformativeDirect
Phenotypic Abnormality (PA)Natal tooth0.000188Highly InformativeDirect
Phenotypic Abnormality (PA)Hepatic fibrosis0.000194Highly InformativeDirect
Phenotypic Abnormality (PA)Metaphyseal spurs0.0003269Highly InformativeDirect
Phenotypic Abnormality (PA)Absent tibia0.0003269Highly InformativeDirect
Phenotypic Abnormality (PA)Nephronophthisis0.0003556Highly InformativeDirect
Phenotypic Abnormality (PA)Glucose intolerance0.0003556Highly InformativeDirect
Phenotypic Abnormality (PA)Cerebellar vermis hypoplasia0.0004088Highly InformativeDirect
Phenotypic Abnormality (PA)Congenital primary aphakia0.000523Highly InformativeDirect
Phenotypic Abnormality (PA)Respiratory distress0.0005606Highly InformativeDirect
Phenotypic Abnormality (PA)Situs inversus totalis0.0005738Highly InformativeDirect
Phenotypic Abnormality (PA)Pulmonary hypoplasia0.0005991Highly InformativeDirect
Phenotypic Abnormality (PA)Nephrogenic diabetes insipidus0.0007943Highly InformativeDirect
Phenotypic Abnormality (PA)Hypoplastic ilia0.01614Highly InformativeInherited
Phenotypic Abnormality (PA)Blindness0.1319Highly InformativeInherited

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

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WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism behavior variant0.00000003025Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.0000000341Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0.0004326Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.0236Least InformativeInherited
Worm Phenotype (WP)cell development variant0.02861Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.04183Least InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.0000461Moderately InformativeDirect
Worm Phenotype (WP)chemical response variant0.008911Moderately InformativeInherited
Worm Phenotype (WP)gametogenesis variant0.03703Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.04618Moderately InformativeInherited
Worm Phenotype (WP)nervous system morphology variant0.1412Moderately InformativeInherited
Worm Phenotype (WP)reproductive system development variant0.1485Moderately InformativeInherited
Worm Phenotype (WP)cell component morphology variant0.3287Moderately InformativeInherited
Worm Phenotype (WP)sensillum morphology variant0.00000005439InformativeDirect
Worm Phenotype (WP)chemotaxis variant0.0002218InformativeDirect
Worm Phenotype (WP)embryonic cell organization biogenesis variant0.0003413InformativeDirect
Worm Phenotype (WP)male morphology variant0.0003802InformativeDirect
Worm Phenotype (WP)dauer arrest variant0.006371InformativeInherited
Worm Phenotype (WP)gonad development variant0.01446InformativeInherited
Worm Phenotype (WP)sexually dimorphic behavior variant0.02664InformativeInherited
Worm Phenotype (WP)mitotic spindle defective early emb0.00001917Highly InformativeDirect
Worm Phenotype (WP)dauer development variant0.0002664Highly InformativeDirect
Worm Phenotype (WP)pronucleus centrosomes defective early emb0.0002993Highly InformativeDirect
Worm Phenotype (WP)division axis defective0.01048Highly InformativeInherited
Worm Phenotype (WP)cell cycle variant0.0115Highly InformativeInherited
Worm Phenotype (WP)mechanosensation variant0.01511Highly InformativeInherited
Worm Phenotype (WP)osmotic avoidance variant0.1042Highly InformativeInherited

Document: WP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)embryonic structure0.03473Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)gonad0.009117Least InformativeInherited
Xenopus ANatomical entity (XAN)genital system0.06553Least InformativeInherited
Xenopus ANatomical entity (XAN)female genitalia0.0008113Moderately InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)seed0.00000001355Least InformativeDirect
Plant ANatomical entity (PAN)whole plant0.04216Least InformativeInherited
Plant ANatomical entity (PAN)shoot axis0.1746Least InformativeInherited
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0.00004498Least InformativeDirect
Plant structure DEvelopment stage (PDE)0 seed germination stage0InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0.0005941Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases0.1064Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Isomerases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.0002096Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.003533Moderately InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases0.003714Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases0.3355Moderately InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups0.4981Moderately InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase0.000000000001985InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0.000004064InformativeDirect
Enzyme Commission (EC)Hexosyltransferases0.005079InformativeInherited
Enzyme Commission (EC)Phosphorus-oxygen lyases1InformativeInherited
Enzyme Commission (EC)With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors0Highly InformativeDirect
Enzyme Commission (EC)Peptidylprolyl isomerase0Highly InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine phosphatase0.0000000002078Highly InformativeDirect
Enzyme Commission (EC)Adenylate cyclase0.0000006585Highly InformativeDirect

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)sensory organs0.002679Least InformativeInherited
Drugbank ATC_code (DB)other ophthalmologicals0.00001611Moderately InformativeDirect
Drugbank ATC_code (DB)genito urinary system and sex hormones0.0001851Moderately InformativeDirect
Drugbank ATC_code (DB)ascorbic acid0.0000002274InformativeDirect
Drugbank ATC_code (DB)ascorbic acid0.0000002274InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

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KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processProtein transport0Moderately InformativeDirect
Biological processUbl conjugation pathway0Moderately InformativeDirect
Biological processDifferentiation0.00000000003017Moderately InformativeDirect
Biological processCell cycle0.0000000331Moderately InformativeDirect
Biological processApoptosis0.000076Moderately InformativeDirect
Biological processImmunity0.005573Moderately InformativeInherited
Biological processMitosis0InformativeDirect
Biological processmRNA processing0InformativeDirect
Biological processPhotosynthesis0InformativeDirect
Biological processMeiosis0.00000000001191InformativeDirect
Biological processNeurogenesis0.0000006524InformativeDirect
Biological processInnate immunity0.00000978InformativeDirect
Biological processER-Golgi transport0Highly InformativeDirect
Biological processCilium biogenesis/degradation0Highly InformativeDirect
Biological processRNA-mediated gene silencing0.000000000003751Highly InformativeDirect
Biological processChromosome partition0.000000001898Highly InformativeDirect
Biological processMyogenesis0.000000003313Highly InformativeDirect
Biological processNonsense-mediated mRNA decay0.0000001337Highly InformativeDirect
Biological processAntiviral defense0.000000657Highly InformativeDirect
Biological processUnfolded protein response0.000005709Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentPlastid0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentMitochondrion0.00000000000008229Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0.00001687Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.0001735Moderately InformativeDirect
Cellular componentMicrotubule0InformativeDirect
Cellular componentSpliceosome0InformativeDirect
Cellular componentThylakoid0InformativeDirect
Cellular componentCilium0InformativeDirect
Cellular componentMitochondrion outer membrane0InformativeDirect
Cellular componentPeroxisome0.000000000001287InformativeDirect
Cellular componentCell outer membrane0.000003507InformativeDirect
Cellular componentChromosome0.0008334InformativeDirect
Cellular componentProteasome0.00005113Highly InformativeDirect
Coding sequence diversityAlternative splicing0.0001999Least InformativeDirect
DiseaseCiliopathy0.00000005427InformativeDirect
DomainRepeat0Least InformativeDirect
DomainTPR repeat0Highly InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationActivator0.0000005485Moderately InformativeDirect
Post-translational modificationDevelopmental protein0.00008752Moderately InformativeDirect
Post-translational modificationIsomerase0.8805Moderately InformativeInherited
Post-translational modificationOxidoreductase1Moderately InformativeInherited
Post-translational modificationChaperone0.00000001166InformativeDirect
Post-translational modificationProtein phosphatase0.0000001535InformativeDirect
Post-translational modificationChromatin regulator0.000007966InformativeDirect
Post-translational modificationInitiation factor0.000009444InformativeDirect
Post-translational modificationRotamase0Highly InformativeDirect
Post-translational modificationDioxygenase0.0000000000001184Highly InformativeDirect
Post-translational modificationAcetylation0Least InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation0.0000000000012Moderately InformativeDirect
Post-translational modificationIsopeptide bond0.000000006861Moderately InformativeDirect
Post-translational modificationPalmitate0.0007287Moderately InformativeDirect
Post-translational modificationThioester bond0Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)glycan metabolism0.0000002027Moderately InformativeDirect
UniPathway (UP)protein ubiquitination0.0005152Moderately InformativeDirect
UniPathway (UP)cellulose metabolism0.000000000003148InformativeDirect
UniPathway (UP)cellulose biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 29 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a TPR-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 29 hidden Markov models representing the TPR-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]