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TPR-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   alpha-alpha superhelix [ 48370] (24)
Superfamily:   TPR-like [ 48452] (8)
Families:   Tetratricopeptide repeat (TPR) [ 48453] (17)
  Transcription factor MalT domain III [ 69094]
  BTAD-like [ 140845]
  PrgX C-terminal domain-like [ 140848]
  Atu0120-like [ 158772]
  SusD-like [ 158775] (3)
  HAT/Suf repeat [ 158782]
  CT2138-like [ 158785]


Superfamily statistics
Genomes (3,133) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 169,526 0 50
Proteins 125,432 0 49


Functional annotation
General category General
Detailed category Protein interaction

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Isomerases0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0.5472Least InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases0.003141Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups0.5544Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases0.1413Least InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.0012Moderately InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0.002744Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases0.3264Moderately InformativeInherited
Enzyme Commission (EC)Methyltransferases0.1514Moderately InformativeInherited
Enzyme Commission (EC)Peptidylprolyl isomerase0InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase0.000000000004361InformativeDirect
Enzyme Commission (EC)Phosphoprotein phosphatase0.000000007897InformativeDirect
Enzyme Commission (EC)With 2-oxoglutarate as one donor, and incorporatio0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)genetic disease0.7224Moderately InformativeInherited
Disease Ontology (DO)autosomal recessive disease0.3351InformativeInherited
Disease Ontology (DO)Bardet-Biedl syndrome0.0002708Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.3805Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.7886Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.2923Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the urinary system0.6329Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal renal morphology0.07233InformativeInherited
Phenotypic Abnormality (PA)Nephronophthisis0.0003241Highly InformativeDirect
Phenotypic Abnormality (PA)Hepatic fibrosis0.0007375Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.1089Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal kidney epithelium morphology0.0009195Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organ system morphology variant0.00000001322Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.00000004716Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0.0005272Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.008303Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.0196Least InformativeInherited
Worm Phenotype (WP)cell development variant0.03078Least InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.00004394Moderately InformativeDirect
Worm Phenotype (WP)chemical response variant0.02004Moderately InformativeInherited
Worm Phenotype (WP)gametogenesis variant0.03691Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.09293Moderately InformativeInherited
Worm Phenotype (WP)nervous system morphology variant0.1066Moderately InformativeInherited
Worm Phenotype (WP)reproductive system development variant0.2446Moderately InformativeInherited
Worm Phenotype (WP)cell component morphology variant0.4001Moderately InformativeInherited
Worm Phenotype (WP)sensillum morphology variant0.00000001501InformativeDirect
Worm Phenotype (WP)chemotaxis variant0.0002704InformativeDirect
Worm Phenotype (WP)embryonic cell organization biogenesis variant0.0003456InformativeDirect
Worm Phenotype (WP)male morphology variant0.0005661InformativeDirect
Worm Phenotype (WP)gonad development variant0.01394InformativeInherited
Worm Phenotype (WP)mitotic spindle defective early emb0.00002245Highly InformativeDirect
Worm Phenotype (WP)pronucleus centrosomes defective early emb0.0002889Highly InformativeDirect
Worm Phenotype (WP)dauer development variant0.0004838Highly InformativeDirect
Worm Phenotype (WP)multiple nuclei0.0007281Highly InformativeDirect
Worm Phenotype (WP)cell cycle variant0.01943Highly InformativeInherited
Worm Phenotype (WP)touch resistant0.3135Highly InformativeInherited

Document: WP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)embryonic structure0.05148Highly InformativeInherited

Document: ZA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)seed0.00000001355Least InformativeDirect
Plant ANatomical entity (PAN)whole plant0.04216Least InformativeInherited
Plant ANatomical entity (PAN)shoot axis0.1746Least InformativeInherited
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0.00004498Least InformativeDirect
Plant structure DEvelopment stage (PDE)0 seed germination stage0InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0.001446Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases0.3993Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Isomerases0Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.0000002252Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.0008257Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0.02511Moderately InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases0.06633Moderately InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups0.7923Moderately InformativeInherited
Enzyme Commission (EC)Acyltransferases0.9224Moderately InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0.000000000000312InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase0.0000000000142InformativeDirect
Enzyme Commission (EC)Hexosyltransferases0.00000008163InformativeDirect
Enzyme Commission (EC)RING-type E3 ubiquitin transferase0.00002754InformativeDirect
Enzyme Commission (EC)Phosphorus-oxygen lyases1InformativeInherited
Enzyme Commission (EC)With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors0Highly InformativeDirect
Enzyme Commission (EC)Peptidylprolyl isomerase0Highly InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine phosphatase0.000000001214Highly InformativeDirect
Enzyme Commission (EC)Adenylate cyclase0.000001306Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processProtein transport0Moderately InformativeDirect
Biological processUbl conjugation pathway0Moderately InformativeDirect
Biological processDifferentiation0.0000000001591Moderately InformativeDirect
Biological processCell cycle0.00000000542Moderately InformativeDirect
Biological processApoptosis0.00009219Moderately InformativeDirect
Biological processImmunity0.02299Moderately InformativeInherited
Biological processMitosis0InformativeDirect
Biological processmRNA processing0InformativeDirect
Biological processPhotosynthesis0InformativeDirect
Biological processMeiosis0.00000000002948InformativeDirect
Biological processNeurogenesis0.000001296InformativeDirect
Biological processInnate immunity0.00004441InformativeDirect
Biological processER-Golgi transport0Highly InformativeDirect
Biological processCilium biogenesis/degradation0Highly InformativeDirect
Biological processRNA-mediated gene silencing0.000000000007756Highly InformativeDirect
Biological processUnfolded protein response0.00000000001488Highly InformativeDirect
Biological processChromosome partition0.0000000004449Highly InformativeDirect
Biological processMyogenesis0.000000005988Highly InformativeDirect
Biological processNonsense-mediated mRNA decay0.000000269Highly InformativeDirect
Biological processAntiviral defense0.000001092Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentMembrane3.332e-16Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentPlastid0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentMitochondrion0.00000000001971Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0.00000007035Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.0002742Moderately InformativeDirect
Cellular componentMicrotubule0InformativeDirect
Cellular componentSpliceosome0InformativeDirect
Cellular componentThylakoid0InformativeDirect
Cellular componentCilium0InformativeDirect
Cellular componentMitochondrion outer membrane0InformativeDirect
Cellular componentPeroxisome0.000000000002752InformativeDirect
Cellular componentCell outer membrane0.000004246InformativeDirect
Cellular componentChromosome0.0004629InformativeDirect
Cellular componentSarcoplasmic reticulum0.0000366Highly InformativeDirect
Cellular componentProteasome0.0000693Highly InformativeDirect
Coding sequence diversityAlternative splicing0.00004995Least InformativeDirect
DiseaseCiliopathy0.00000001754InformativeDirect
DomainRepeat0Least InformativeDirect
DomainTPR repeat0Highly InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationActivator0.0000008983Moderately InformativeDirect
Post-translational modificationDevelopmental protein0.0001973Moderately InformativeDirect
Post-translational modificationIsomerase0.9098Moderately InformativeInherited
Post-translational modificationOxidoreductase1Moderately InformativeInherited
Post-translational modificationChaperone0.000000004686InformativeDirect
Post-translational modificationProtein phosphatase0.0000002204InformativeDirect
Post-translational modificationChromatin regulator0.00001129InformativeDirect
Post-translational modificationInitiation factor0.00001168InformativeDirect
Post-translational modificationRotamase0Highly InformativeDirect
Post-translational modificationDioxygenase0.0000000000002623Highly InformativeDirect
Post-translational modificationAcetylation0Least InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation0.0000000007786Moderately InformativeDirect
Post-translational modificationIsopeptide bond0.0000005041Moderately InformativeDirect
Post-translational modificationMyristate0.0006636InformativeDirect
Post-translational modificationThioester bond0Highly InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 29 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a TPR-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 29 hidden Markov models representing the TPR-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]