SUPERFAMILY 1.75 HMM library and genome assignments server

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TPR-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   alpha-alpha superhelix [ 48370] (24)
Superfamily:   TPR-like [ 48452] (8)
Families:   Tetratricopeptide repeat (TPR) [ 48453] (17)
  Transcription factor MalT domain III [ 69094]
  BTAD-like [ 140845]
  PrgX C-terminal domain-like [ 140848]
  Atu0120-like [ 158772]
  SusD-like [ 158775] (3)
  HAT/Suf repeat [ 158782]
  CT2138-like [ 158785]


Superfamily statistics
Genomes (3,133) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 169,526 955,257 50
Proteins 125,432 730,800 49


Functional annotation
General category General
Detailed category Protein interaction

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Isomerases0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0.5472Least InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases0.003141Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups0.5544Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases0.1413Least InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.0012Moderately InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0.002744Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases0.3264Moderately InformativeInherited
Enzyme Commission (EC)Methyltransferases0.1514Moderately InformativeInherited
Enzyme Commission (EC)Peptidylprolyl isomerase0InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase0.000000000004361InformativeDirect
Enzyme Commission (EC)Phosphoprotein phosphatase0.000000007897InformativeDirect
Enzyme Commission (EC)With 2-oxoglutarate as one donor, and incorporatio0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)genetic disease0.7219Moderately InformativeInherited
Disease Ontology (DO)autosomal recessive disease0.3353InformativeInherited
Disease Ontology (DO)Bardet-Biedl syndrome0.0002735Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the eye0.0005456Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.3416Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.5606Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.1228Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper urinary tract0.53Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal renal morphology0.1955InformativeInherited
Phenotypic Abnormality (PA)Nephronophthisis0.0004017Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.1089Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal kidney epithelium morphology0.0008488Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organ system morphology variant0.00000007426Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0.000004211Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.00001902Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.000759Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.006751Least InformativeInherited
Worm Phenotype (WP)cell development variant0.0326Least InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.0002477Moderately InformativeDirect
Worm Phenotype (WP)germ cell development variant0.002496Moderately InformativeInherited
Worm Phenotype (WP)locomotion variant0.007571Moderately InformativeInherited
Worm Phenotype (WP)drug response variant0.02025Moderately InformativeInherited
Worm Phenotype (WP)nervous system morphology variant0.1457Moderately InformativeInherited
Worm Phenotype (WP)cell organization biogenesis variant0.1706Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.1923Moderately InformativeInherited
Worm Phenotype (WP)reproductive system development variant0.4387Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.6957Moderately InformativeInherited
Worm Phenotype (WP)sensillum morphology variant0.00000003757InformativeDirect
Worm Phenotype (WP)embryonic cell organization biogenesis variant0.00009021InformativeDirect
Worm Phenotype (WP)male morphology variant0.00009555InformativeDirect
Worm Phenotype (WP)somatic gonad development variant0.0001033InformativeDirect
Worm Phenotype (WP)male gonad development variant0.0003247InformativeDirect
Worm Phenotype (WP)pesticide response variant0.00324InformativeInherited
Worm Phenotype (WP)cytoskeleton organization biogenesis variant0.005468InformativeInherited
Worm Phenotype (WP)drug resistant0.008634InformativeInherited
Worm Phenotype (WP)mechanosensation variant0.0193InformativeInherited
Worm Phenotype (WP)chemotaxis variant0.0758InformativeInherited
Worm Phenotype (WP)neuron morphology variant0.4507InformativeInherited
Worm Phenotype (WP)antihelmintic response variant0.000012Highly InformativeDirect
Worm Phenotype (WP)nuclear number variant0.0004116Highly InformativeDirect
Worm Phenotype (WP)cell cycle variant0.007093Highly InformativeInherited
Worm Phenotype (WP)division axis defective0.009765Highly InformativeInherited
Worm Phenotype (WP)touch resistant0.2264Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)nervous system0.7192Least InformativeInherited
Fly Anatomy (FA)adult0.9471Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.9679Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.2015Moderately InformativeInherited
Fly Anatomy (FA)adult segment0.9486Moderately InformativeInherited
Fly Anatomy (FA)head0.9574Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system1Moderately InformativeInherited
Fly Anatomy (FA)nerve0.1922InformativeInherited
Fly Anatomy (FA)adult procephalic segment0.8726InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)embryonic structure0.145InformativeInherited

Document: ZA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)seed0.00000001357Least InformativeDirect
Plant ANatomical entity (PAN)whole plant0.04222Least InformativeInherited
Plant ANatomical entity (PAN)shoot axis0.1747Least InformativeInherited
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0.00004502Least InformativeDirect
Plant structure DEvelopment stage (PDE)0 seed germination stage0InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0.04493Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases0.4859Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Isomerases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0.00000009922Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.0000002565Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.001486Moderately InformativeInherited
Enzyme Commission (EC)Aminoacyltransferases0.00213Moderately InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases0.06462Moderately InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Moderately InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0InformativeDirect
Enzyme Commission (EC)Hexosyltransferases0InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0.000000000001461InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase0.00000000001815InformativeDirect
Enzyme Commission (EC)RING-type E3 ubiquitin transferase0.00004718InformativeDirect
Enzyme Commission (EC)Phosphorus-oxygen lyases1InformativeInherited
Enzyme Commission (EC)With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors0Highly InformativeDirect
Enzyme Commission (EC)Peptidylprolyl isomerase0Highly InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine phosphatase0.000000002502Highly InformativeDirect
Enzyme Commission (EC)Adenylate cyclase0.000001933Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 51 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a TPR-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 51 hidden Markov models representing the TPR-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]