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TPR-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   alpha-alpha superhelix [ 48370] (24)
Superfamily:   TPR-like [ 48452] (8)
Families:   Tetratricopeptide repeat (TPR) [ 48453] (17)
  Transcription factor MalT domain III [ 69094]
  BTAD-like [ 140845]
  PrgX C-terminal domain-like [ 140848]
  Atu0120-like [ 158772]
  SusD-like [ 158775] (3)
  HAT/Suf repeat [ 158782]
  CT2138-like [ 158785]


Superfamily statistics
Genomes (3,133) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 169,526 725,715 50
Proteins 125,432 556,248 49


Functional annotation
General category General
Detailed category Protein interaction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular component organization or biogenesis0.000035610.0000000009092Least InformativeDirect
Biological Process (BP)biological regulation11Least InformativeInherited
Biological Process (BP)multicellular organismal process11Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)macromolecule localization0.00038640Moderately InformativeDirect
Biological Process (BP)regulation of response to stimulus11Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process11Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.98770.9496Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.99861Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.076961Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.4611Moderately InformativeInherited
Biological Process (BP)generation of precursor metabolites and energy0.56371Moderately InformativeInherited
Biological Process (BP)cellular component assembly0.32820.0000001559Moderately InformativeInherited
Biological Process (BP)macromolecular complex subunit organization0.18380.004547Moderately InformativeInherited
Biological Process (BP)protein complex biogenesis0.070740.1644Moderately InformativeInherited
Biological Process (BP)cellular localization0.0042410Moderately InformativeInherited
Biological Process (BP)nitrogen compound transport0.016140.0000000000001939Moderately InformativeInherited
Biological Process (BP)organelle organization0.35930Moderately InformativeInherited
Biological Process (BP)organic substance transport0.10310.0000001283Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.87321Moderately InformativeInherited
Biological Process (BP)intracellular transport0.00070080InformativeDirect
Biological Process (BP)negative regulation of response to stimulus0.59241InformativeInherited
Biological Process (BP)regulation of catabolic process0.10950.000928InformativeInherited
Biological Process (BP)regulation of proteolysis0.27060.00005432InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis0.011571InformativeInherited
Biological Process (BP)positive regulation of developmental process0.012231InformativeInherited
Biological Process (BP)cellular protein complex assembly0.066340.00000004407InformativeInherited
Biological Process (BP)positive regulation of cellular component organization0.0092710.2921InformativeInherited
Biological Process (BP)regulation of organelle organization0.0099650.00002841InformativeInherited
Biological Process (BP)vesicle-mediated transport0.14571InformativeInherited
Biological Process (BP)protein folding0.000030420Highly InformativeDirect
Biological Process (BP)positive regulation of organelle organization0.000054850.0000001476Highly InformativeDirect
Biological Process (BP)regulation of cellular response to stress0.048820.1437Highly InformativeInherited
Biological Process (BP)regulation of protein catabolic process0.0017110.000002689Highly InformativeInherited
Biological Process (BP)regulation of mitochondrion organization0.0000002730.231Highly InformativeInherited
Biological Process (BP)Golgi vesicle transport0.0029370.03487Highly InformativeInherited
Biological Process (BP)multicellular organismal homeostasis0.012270.2681Highly InformativeInherited
Biological Process (BP)anatomical structure homeostasis0.011920.2012Highly InformativeInherited
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)transporter activity11Moderately InformativeInherited
Molecular Function (MF)P-P-bond-hydrolysis-driven transmembrane transporter activity0.2391InformativeInherited
Molecular Function (MF)protein transporter activity0.0000099060.0001971Highly InformativeDirect
Molecular Function (MF)macromolecule transmembrane transporter activity0.00000063910.00000009267Highly InformativeDirect
Molecular Function (MF)amide transmembrane transporter activity0.000040580.0001936Highly InformativeDirect
Molecular Function (MF)chaperone binding0.00021540.00006831Highly InformativeDirect
Cellular Component (CC)protein complex0.0001560.0001138Least InformativeDirect
Cellular Component (CC)intracellular organelle part0.000013010.000008076Least InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle0.21010.4936Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.0061690.02888Least InformativeInherited
Cellular Component (CC)membrane0.36491Least InformativeInherited
Cellular Component (CC)non-membrane-bounded organelle10.03738Least InformativeInherited
Cellular Component (CC)mitochondrial envelope0.076930.05833Moderately InformativeInherited
Cellular Component (CC)mitochondrial protein complex0.42750.9806Moderately InformativeInherited
Cellular Component (CC)membrane protein complex0.000000056590.6894Moderately InformativeInherited
Cellular Component (CC)endomembrane system0.26250.9648Moderately InformativeInherited
Cellular Component (CC)bounding membrane of organelle0.00000040650.04068Moderately InformativeInherited
Cellular Component (CC)intrinsic component of membrane0.10391Moderately InformativeInherited
Cellular Component (CC)vesicle11Moderately InformativeInherited
Cellular Component (CC)cytoskeleton0.17940.2397Moderately InformativeInherited
Cellular Component (CC)whole membrane0.0000002310.0596Moderately InformativeInherited
Cellular Component (CC)outer membrane0.00000016510.000000002419InformativeDirect
Cellular Component (CC)microbody0.0000091590.0001866InformativeDirect
Cellular Component (CC)endoplasmic reticulum membrane0.0000085360.3008InformativeInherited
Cellular Component (CC)Golgi apparatus0.51151InformativeInherited
Cellular Component (CC)microtubule cytoskeleton0.0088280.000000001743InformativeInherited
Cellular Component (CC)mitochondrial outer membrane0.0000000016540.000000000003564Highly InformativeDirect
Cellular Component (CC)microtubule organizing center0.00026450.00004673Highly InformativeDirect
Cellular Component (CC)integral component of endoplasmic reticulum membrane0.00000000055620.0002637Highly InformativeDirect
Cellular Component (CC)microbody membrane0.0000006530.00000001327Highly InformativeDirect
Cellular Component (CC)peroxisomal part0.00096270.00001639Highly InformativeDirect
Cellular Component (CC)intrinsic component of organelle membrane0.0038530.2241Highly InformativeInherited
Cellular Component (CC)Golgi-associated vesicle0.0009060.1012Highly InformativeInherited
Cellular Component (CC)coated vesicle0.0021810.3326Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 0.0000000009092 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 0.002853 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organelle organization 0 Moderately Informative Direct
Biological Process (BP) cellular component assembly 0.0000001559 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0 Moderately Informative Direct
Biological Process (BP) cellular localization 0 Moderately Informative Direct
Biological Process (BP) organic substance transport 0.0000001283 Moderately Informative Direct
Biological Process (BP) nitrogen compound transport 0.0000000000001939 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.6555 Moderately Informative Inherited
Biological Process (BP) protein complex biogenesis 0.1644 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.08219 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) animal organ development 1 Moderately Informative Inherited
Biological Process (BP) generation of precursor metabolites and energy 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.5444 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.9496 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.004547 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.9212 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.3746 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.8495 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) single organism signaling 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.002752 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) microtubule-based process 0 Informative Direct
Biological Process (BP) regulation of catabolic process 0.000928 Informative Direct
Biological Process (BP) protein transport 0.0004167 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0.0005807 Informative Direct
Biological Process (BP) cell cycle process 0.0005594 Informative Direct
Biological Process (BP) regulation of proteolysis 0.00005432 Informative Direct
Biological Process (BP) regulation of organelle organization 0.00002841 Informative Direct
Biological Process (BP) nucleobase-containing compound catabolic process 0.0006405 Informative Direct
Biological Process (BP) cellular protein complex assembly 0.00000004407 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0.000000005756 Informative Direct
Biological Process (BP) intracellular transport 0 Informative Direct
Biological Process (BP) organelle assembly 0.0000000008924 Informative Direct
Biological Process (BP) single-organism cellular localization 0 Informative Direct
Biological Process (BP) negative regulation of cellular protein metabolic process 0.0413 Informative Inherited
Biological Process (BP) negative regulation of molecular function 0.9102 Informative Inherited
Biological Process (BP) regulation of phosphorylation 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 0.9512 Informative Inherited
Biological Process (BP) regulation of protein modification process 0.814 Informative Inherited
Biological Process (BP) regulation of cell cycle 0.9042 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 1 Informative Inherited
Biological Process (BP) RNA modification 0.2625 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 0.8299 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) positive regulation of developmental process 1 Informative Inherited
Biological Process (BP) response to radiation 0.8739 Informative Inherited
Biological Process (BP) response to temperature stimulus 0.6349 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) regulation of apoptotic process 1 Informative Inherited
Biological Process (BP) regulation of cellular component movement 1 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 1 Informative Inherited
Biological Process (BP) regulation of transferase activity 1 Informative Inherited
Biological Process (BP) mitochondrion organization 0.001439 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 1 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.2921 Informative Inherited
Biological Process (BP) actin cytoskeleton organization 1 Informative Inherited
Biological Process (BP) cellular component morphogenesis 1 Informative Inherited
Biological Process (BP) supramolecular fiber organization 0.2049 Informative Inherited
Biological Process (BP) chromosome organization 1 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 0.4183 Informative Inherited
Biological Process (BP) cell development 1 Informative Inherited
Biological Process (BP) movement of cell or subcellular component 0.001881 Informative Inherited
Biological Process (BP) positive regulation of gene expression 1 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) embryo development 0.3327 Informative Inherited
Biological Process (BP) animal organ morphogenesis 1 Informative Inherited
Biological Process (BP) organelle localization 1 Informative Inherited
Biological Process (BP) regulation of cellular amide metabolic process 0.6906 Informative Inherited
Biological Process (BP) DNA metabolic process 1 Informative Inherited
Biological Process (BP) proteolysis 0.7393 Informative Inherited
Biological Process (BP) transmembrane transport 1 Informative Inherited
Biological Process (BP) negative regulation of gene expression 0.6841 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) post-embryonic development 1 Informative Inherited
Biological Process (BP) reproductive system development 1 Informative Inherited
Biological Process (BP) single organism reproductive process 0.8387 Informative Inherited
Biological Process (BP) locomotion 1 Informative Inherited
Biological Process (BP) multi-organism reproductive process 0.9294 Informative Inherited
Biological Process (BP) localization of cell 1 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.8991 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 1 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.2484 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) vesicle-mediated transport 1 Informative Inherited
Biological Process (BP) protein localization to organelle 0.9312 Informative Inherited
Biological Process (BP) ribonucleoprotein complex subunit organization 0.8034 Informative Inherited
Biological Process (BP) RNA catabolic process 0.0002569 Highly Informative Direct
Biological Process (BP) protein folding 0 Highly Informative Direct
Biological Process (BP) microtubule-based movement 0 Highly Informative Direct
Biological Process (BP) protein alkylation 0.0000575 Highly Informative Direct
Biological Process (BP) positive regulation of organelle organization 0.0000001476 Highly Informative Direct
Biological Process (BP) cell projection assembly 0 Highly Informative Direct
Biological Process (BP) negative regulation of protein modification process 0.000441 Highly Informative Direct
Biological Process (BP) regulation of chromosome organization 0.000000007937 Highly Informative Direct
Biological Process (BP) regulation of protein catabolic process 0.000002689 Highly Informative Direct
Biological Process (BP) macromolecule glycosylation 0.00005359 Highly Informative Direct
Biological Process (BP) macromolecule methylation 0.0003008 Highly Informative Direct
Biological Process (BP) positive regulation of proteolysis 0.00001749 Highly Informative Direct
Biological Process (BP) regulation of chromosome segregation 0.00002422 Highly Informative Direct
Biological Process (BP) establishment of protein localization to mitochondrion 0.00003864 Highly Informative Direct
Biological Process (BP) nuclear chromosome segregation 0.00005097 Highly Informative Direct
Biological Process (BP) regulation of protein modification by small protein conjugation or removal 0.0000000002651 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.1437 Highly Informative Inherited
Biological Process (BP) negative regulation of transferase activity 0.09185 Highly Informative Inherited
Biological Process (BP) negative regulation of phosphate metabolic process 1 Highly Informative Inherited
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.7648 Highly Informative Inherited
Biological Process (BP) carbohydrate homeostasis 0.528 Highly Informative Inherited
Biological Process (BP) regulation of carbohydrate biosynthetic process 0.0906 Highly Informative Inherited
Biological Process (BP) regulation of mitochondrion organization 0.231 Highly Informative Inherited
Biological Process (BP) kidney development 0.8501 Highly Informative Inherited
Biological Process (BP) histone modification 0.6704 Highly Informative Inherited
Biological Process (BP) demethylation 0.02974 Highly Informative Inherited
Biological Process (BP) cellular response to abiotic stimulus 0.2309 Highly Informative Inherited
Biological Process (BP) protein modification by small protein conjugation 0.003411 Highly Informative Inherited
Biological Process (BP) response to cold 0.7176 Highly Informative Inherited
Biological Process (BP) regulation of microtubule-based process 0.01 Highly Informative Inherited
Biological Process (BP) neuron development 1 Highly Informative Inherited
Biological Process (BP) pigmentation 0.5926 Highly Informative Inherited
Biological Process (BP) establishment of organelle localization 0.05744 Highly Informative Inherited
Biological Process (BP) peptidyl-lysine modification 0.7128 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular catabolic process 0.003168 Highly Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle phase transition 0.007677 Highly Informative Inherited
Biological Process (BP) positive regulation of cell cycle process 0.02091 Highly Informative Inherited
Biological Process (BP) positive regulation of mitotic cell cycle 0.006791 Highly Informative Inherited
Biological Process (BP) cellular component assembly involved in morphogenesis 0.02276 Highly Informative Inherited
Biological Process (BP) actomyosin structure organization 0.01142 Highly Informative Inherited
Biological Process (BP) striated muscle cell development 0.08525 Highly Informative Inherited
Biological Process (BP) plasma membrane bounded cell projection organization 1 Highly Informative Inherited
Biological Process (BP) multicellular organism metabolic process 0.001707 Highly Informative Inherited
Biological Process (BP) response to endoplasmic reticulum stress 0.01074 Highly Informative Inherited
Biological Process (BP) microtubule cytoskeleton organization 0.8074 Highly Informative Inherited
Biological Process (BP) mitochondrial respiratory chain complex assembly 0.6271 Highly Informative Inherited
Biological Process (BP) nuclear division 1 Highly Informative Inherited
Biological Process (BP) regulation of mitotic nuclear division 0.001402 Highly Informative Inherited
Biological Process (BP) embryonic organ development 0.6992 Highly Informative Inherited
Biological Process (BP) sensory organ morphogenesis 0.1605 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 0.8635 Highly Informative Inherited
Biological Process (BP) DNA replication 0.2227 Highly Informative Inherited
Biological Process (BP) cellular protein catabolic process 0.005576 Highly Informative Inherited
Biological Process (BP) modification-dependent macromolecule catabolic process 0.6701 Highly Informative Inherited
Biological Process (BP) protein import 0.03045 Highly Informative Inherited
Biological Process (BP) gene silencing 0.01027 Highly Informative Inherited
Biological Process (BP) regulation of gene expression, epigenetic 0.4766 Highly Informative Inherited
Biological Process (BP) seed development 0.06576 Highly Informative Inherited
Biological Process (BP) glycoprotein metabolic process 0.01102 Highly Informative Inherited
Biological Process (BP) germ cell development 0.5344 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.3922 Highly Informative Inherited
Biological Process (BP) epithelial cell differentiation 1 Highly Informative Inherited
Biological Process (BP) Golgi vesicle transport 0.03487 Highly Informative Inherited
Biological Process (BP) protein targeting 0.1329 Highly Informative Inherited
Biological Process (BP) mitochondrial transport 0.001331 Highly Informative Inherited
Biological Process (BP) multicellular organismal homeostasis 0.2681 Highly Informative Inherited
Biological Process (BP) anatomical structure homeostasis 0.2012 Highly Informative Inherited
Biological Process (BP) RNA splicing 0.004133 Highly Informative Inherited
Biological Process (BP) mRNA processing 0.104 Highly Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 0.3563 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) isomerase activity 0.0005686 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) structural molecule activity 0.8322 Moderately Informative Inherited
Molecular Function (MF) molecular function regulator 1 Moderately Informative Inherited
Molecular Function (MF) nucleotidyltransferase activity 0.006788 Informative Inherited
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring one-carbon groups 0.939 Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 1 Informative Inherited
Molecular Function (MF) P-P-bond-hydrolysis-driven transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 0.06689 Informative Inherited
Molecular Function (MF) amide binding 0.05778 Informative Inherited
Molecular Function (MF) enzyme inhibitor activity 0.1761 Informative Inherited
Molecular Function (MF) enzyme binding 0.6463 Informative Inherited
Molecular Function (MF) macromolecular complex binding 0.02012 Informative Inherited
Molecular Function (MF) UDP-glycosyltransferase activity 0.00002769 Highly Informative Direct
Molecular Function (MF) protein transporter activity 0.0001971 Highly Informative Direct
Molecular Function (MF) ubiquitin-like protein transferase activity 0.000958 Highly Informative Direct
Molecular Function (MF) macromolecule transmembrane transporter activity 0.00000009267 Highly Informative Direct
Molecular Function (MF) amide transmembrane transporter activity 0.0001936 Highly Informative Direct
Molecular Function (MF) chaperone binding 0.00006831 Highly Informative Direct
Molecular Function (MF) dioxygenase activity 0.000004575 Highly Informative Direct
Molecular Function (MF) S-adenosylmethionine-dependent methyltransferase activity 0.3838 Highly Informative Inherited
Molecular Function (MF) acetyltransferase activity 0.1326 Highly Informative Inherited
Molecular Function (MF) protein domain specific binding 0.4817 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 0.008561 Highly Informative Inherited
Molecular Function (MF) transferase activity, transferring hexosyl groups 0.004579 Highly Informative Inherited
Molecular Function (MF) drug binding 0.003457 Highly Informative Inherited
Molecular Function (MF) GTPase regulator activity 1 Highly Informative Inherited
Molecular Function (MF) peptide binding 0.01921 Highly Informative Inherited
Molecular Function (MF) kinase regulator activity 0.3875 Highly Informative Inherited
Cellular Component (CC) protein complex 0.0001138 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.000008076 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.4936 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.02888 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.03738 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) nuclear part 0.00000005956 Moderately Informative Direct
Cellular Component (CC) transferase complex 0.00000075 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 0.07155 Moderately Informative Inherited
Cellular Component (CC) mitochondrial envelope 0.05833 Moderately Informative Inherited
Cellular Component (CC) mitochondrial protein complex 0.9806 Moderately Informative Inherited
Cellular Component (CC) membrane protein complex 0.6894 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 0.9648 Moderately Informative Inherited
Cellular Component (CC) bounding membrane of organelle 0.04068 Moderately Informative Inherited
Cellular Component (CC) intrinsic component of membrane 1 Moderately Informative Inherited
Cellular Component (CC) vesicle 1 Moderately Informative Inherited
Cellular Component (CC) cell projection 0.02464 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.2397 Moderately Informative Inherited
Cellular Component (CC) whole membrane 0.0596 Moderately Informative Inherited
Cellular Component (CC) ubiquitin ligase complex 0.00000000001312 Informative Direct
Cellular Component (CC) cilium 0 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 0.000000001743 Informative Direct
Cellular Component (CC) outer membrane 0.000000002419 Informative Direct
Cellular Component (CC) microbody 0.0001866 Informative Direct
Cellular Component (CC) plasma membrane bounded cell projection part 0.0009327 Informative Direct
Cellular Component (CC) chromosome 0.003377 Informative Inherited
Cellular Component (CC) neuron projection 1 Informative Inherited
Cellular Component (CC) endoplasmic reticulum membrane 0.3008 Informative Inherited
Cellular Component (CC) Golgi apparatus 1 Informative Inherited
Cellular Component (CC) supramolecular polymer 1 Informative Inherited
Cellular Component (CC) nucleoplasm part 0.8178 Informative Inherited
Cellular Component (CC) transferase complex, transferring phosphorus-containing groups 1 Informative Inherited
Cellular Component (CC) nuclear ubiquitin ligase complex 0 Highly Informative Direct
Cellular Component (CC) mitochondrial outer membrane 0.000000000003564 Highly Informative Direct
Cellular Component (CC) microtubule organizing center 0.00004673 Highly Informative Direct
Cellular Component (CC) transcription elongation factor complex 0.000003128 Highly Informative Direct
Cellular Component (CC) CCR4-NOT complex 0.0000001468 Highly Informative Direct
Cellular Component (CC) integral component of endoplasmic reticulum membrane 0.0002637 Highly Informative Direct
Cellular Component (CC) small nuclear ribonucleoprotein complex 0.00003931 Highly Informative Direct
Cellular Component (CC) protein acetyltransferase complex 0.0003271 Highly Informative Direct
Cellular Component (CC) microbody membrane 0.00000001327 Highly Informative Direct
Cellular Component (CC) peroxisomal part 0.00001639 Highly Informative Direct
Cellular Component (CC) nuclear chromosome part 1 Highly Informative Inherited
Cellular Component (CC) chromatin 0.1609 Highly Informative Inherited
Cellular Component (CC) photoreceptor cell cilium 0.1916 Highly Informative Inherited
Cellular Component (CC) intrinsic component of organelle membrane 0.2241 Highly Informative Inherited
Cellular Component (CC) Golgi-associated vesicle 0.1012 Highly Informative Inherited
Cellular Component (CC) coated vesicle 0.3326 Highly Informative Inherited
Cellular Component (CC) sarcomere 0.009767 Highly Informative Inherited
Cellular Component (CC) peptidase complex 0.5348 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Isomerases0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0.5472Least InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases0.003141Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups0.5544Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases0.1413Least InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.0012Moderately InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0.002744Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases0.3264Moderately InformativeInherited
Enzyme Commission (EC)Methyltransferases0.1514Moderately InformativeInherited
Enzyme Commission (EC)Peptidylprolyl isomerase0InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase0.000000000004361InformativeDirect
Enzyme Commission (EC)Phosphoprotein phosphatase0.000000007897InformativeDirect
Enzyme Commission (EC)With 2-oxoglutarate as one donor, and incorporatio0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processProtein transport0Moderately InformativeDirect
Biological processUbl conjugation pathway0Moderately InformativeDirect
Biological processDifferentiation0.00000000008463Moderately InformativeDirect
Biological processCell cycle0.000000005791Moderately InformativeDirect
Biological processApoptosis0.00009151Moderately InformativeDirect
Biological processImmunity0.01053Moderately InformativeInherited
Biological processMitosis0InformativeDirect
Biological processmRNA processing0InformativeDirect
Biological processPhotosynthesis0InformativeDirect
Biological processMeiosis0.00000000002243InformativeDirect
Biological processNeurogenesis0.0000009534InformativeDirect
Biological processInnate immunity0.00001344InformativeDirect
Biological processER-Golgi transport0Highly InformativeDirect
Biological processCilium biogenesis/degradation0Highly InformativeDirect
Biological processRNA-mediated gene silencing0.000000000005561Highly InformativeDirect
Biological processChromosome partition0.0000000004067Highly InformativeDirect
Biological processMyogenesis0.000000005065Highly InformativeDirect
Biological processNonsense-mediated mRNA decay0.0000002576Highly InformativeDirect
Biological processAntiviral defense0.0000008173Highly InformativeDirect
Biological processUnfolded protein response0.000005934Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentPlastid0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentMitochondrion0.00000000000001409Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0.000005324Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.0001751Moderately InformativeDirect
Cellular componentMicrotubule0InformativeDirect
Cellular componentSpliceosome0InformativeDirect
Cellular componentThylakoid0InformativeDirect
Cellular componentCilium0InformativeDirect
Cellular componentMitochondrion outer membrane0InformativeDirect
Cellular componentPeroxisome0.00000000000216InformativeDirect
Cellular componentCell outer membrane0.000004114InformativeDirect
Cellular componentProteasome0.00006113Highly InformativeDirect
Coding sequence diversityAlternative splicing0.0001019Least InformativeDirect
DiseaseCiliopathy0.00000000959InformativeDirect
DomainRepeat0Least InformativeDirect
DomainTPR repeat0Highly InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationActivator0.0000003989Moderately InformativeDirect
Post-translational modificationDevelopmental protein0.0001365Moderately InformativeDirect
Post-translational modificationIsomerase0.8881Moderately InformativeInherited
Post-translational modificationOxidoreductase1Moderately InformativeInherited
Post-translational modificationChaperone0.000000002176InformativeDirect
Post-translational modificationProtein phosphatase0.0000001781InformativeDirect
Post-translational modificationChromatin regulator0.000009583InformativeDirect
Post-translational modificationInitiation factor0.00001064InformativeDirect
Post-translational modificationRotamase0Highly InformativeDirect
Post-translational modificationDioxygenase0.0000000000001987Highly InformativeDirect
Post-translational modificationAcetylation0Least InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation0.00000000004536Moderately InformativeDirect
Post-translational modificationIsopeptide bond0.0000002636Moderately InformativeDirect
Post-translational modificationPalmitate0.0009413Moderately InformativeDirect
Post-translational modificationThioester bond0Highly InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 29 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a TPR-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 29 hidden Markov models representing the TPR-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]