SUPERFAMILY 1.75 HMM library and genome assignments server

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TPR-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   alpha-alpha superhelix [ 48370] (24)
Superfamily:   TPR-like [ 48452] (8)
Families:   Tetratricopeptide repeat (TPR) [ 48453] (17)
  Transcription factor MalT domain III [ 69094]
  BTAD-like [ 140845]
  PrgX C-terminal domain-like [ 140848]
  Atu0120-like [ 158772]
  SusD-like [ 158775] (3)
  HAT/Suf repeat [ 158782]
  CT2138-like [ 158785]


Superfamily statistics
Genomes (3,133) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 169,526 955,257 50
Proteins 125,432 730,800 49


Functional annotation
General category General
Detailed category Protein interaction

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Isomerases0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0.5472Least InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases0.003141Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups0.5544Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases0.1413Least InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.0012Moderately InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0.002744Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases0.3264Moderately InformativeInherited
Enzyme Commission (EC)Methyltransferases0.1514Moderately InformativeInherited
Enzyme Commission (EC)Peptidylprolyl isomerase0InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase0.000000000004361InformativeDirect
Enzyme Commission (EC)Phosphoprotein phosphatase0.000000007897InformativeDirect
Enzyme Commission (EC)With 2-oxoglutarate as one donor, and incorporatio0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)genetic disease0.7224Moderately InformativeInherited
Disease Ontology (DO)autosomal recessive disease0.3351InformativeInherited
Disease Ontology (DO)Bardet-Biedl syndrome0.0002708Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the skeletal system0.05081Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.09034Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.3929Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.5253Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.8021Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limb bone morphology0.1361Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.2919Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system morphology0.3089Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the urinary system0.6357Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal renal morphology0.07437InformativeInherited
Phenotypic Abnormality (PA)Nephronophthisis0.0003237Highly InformativeDirect
Phenotypic Abnormality (PA)Postaxial polydactyly0.0004466Highly InformativeDirect
Phenotypic Abnormality (PA)Hepatic fibrosis0.0007431Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.1089Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal kidney epithelium morphology0.0009198Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organ system morphology variant0.00000001568Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.00000005068Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0.0006094Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.008736Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.02013Least InformativeInherited
Worm Phenotype (WP)cell development variant0.03512Least InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.00004541Moderately InformativeDirect
Worm Phenotype (WP)chemical response variant0.0199Moderately InformativeInherited
Worm Phenotype (WP)gametogenesis variant0.0339Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.09154Moderately InformativeInherited
Worm Phenotype (WP)nervous system morphology variant0.1178Moderately InformativeInherited
Worm Phenotype (WP)reproductive system development variant0.2392Moderately InformativeInherited
Worm Phenotype (WP)cell component morphology variant0.3751Moderately InformativeInherited
Worm Phenotype (WP)sensillum morphology variant0.0000000143InformativeDirect
Worm Phenotype (WP)chemotaxis variant0.0002794InformativeDirect
Worm Phenotype (WP)embryonic cell organization biogenesis variant0.0003538InformativeDirect
Worm Phenotype (WP)male morphology variant0.0005648InformativeDirect
Worm Phenotype (WP)dauer arrest variant0.009065InformativeInherited
Worm Phenotype (WP)mechanosensation variant0.0144InformativeInherited
Worm Phenotype (WP)gonad development variant0.01442InformativeInherited
Worm Phenotype (WP)mitotic spindle defective early emb0.00002236Highly InformativeDirect
Worm Phenotype (WP)pronucleus centrosomes defective early emb0.0002882Highly InformativeDirect
Worm Phenotype (WP)dauer development variant0.0004666Highly InformativeDirect
Worm Phenotype (WP)multiple nuclei0.0007585Highly InformativeDirect
Worm Phenotype (WP)cell cycle variant0.01911Highly InformativeInherited
Worm Phenotype (WP)touch resistant0.3131Highly InformativeInherited

Document: WP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)embryonic structure0.05923Highly InformativeInherited

Document: ZA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)seed0.00000001355Least InformativeDirect
Plant ANatomical entity (PAN)whole plant0.04216Least InformativeInherited
Plant ANatomical entity (PAN)shoot axis0.1746Least InformativeInherited
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0.00004498Least InformativeDirect
Plant structure DEvelopment stage (PDE)0 seed germination stage0InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0.001079Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases0.4002Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Isomerases0Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.0000002335Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.0008232Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0.02318Moderately InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases0.06613Moderately InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups0.8683Moderately InformativeInherited
Enzyme Commission (EC)Acyltransferases0.9144Moderately InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0.0000000000003155InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase0.00000000001548InformativeDirect
Enzyme Commission (EC)Hexosyltransferases0.00000008788InformativeDirect
Enzyme Commission (EC)RING-type E3 ubiquitin transferase0.00002166InformativeDirect
Enzyme Commission (EC)Phosphorus-oxygen lyases1InformativeInherited
Enzyme Commission (EC)With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors0Highly InformativeDirect
Enzyme Commission (EC)Peptidylprolyl isomerase0Highly InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine phosphatase0.000000001209Highly InformativeDirect
Enzyme Commission (EC)Adenylate cyclase0.000001299Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 29 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a TPR-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 29 hidden Markov models representing the TPR-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]