SUPERFAMILY 1.75 HMM library and genome assignments server

TPR-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   alpha-alpha superhelix [ 48370] (24)
Superfamily:   TPR-like [ 48452] (8)
Families:   Tetratricopeptide repeat (TPR) [ 48453] (17)
  Transcription factor MalT domain III [ 69094]
  BTAD-like [ 140845]
  PrgX C-terminal domain-like [ 140848]
  Atu0120-like [ 158772]
  SusD-like [ 158775] (3)
  HAT/Suf repeat [ 158782]
  CT2138-like [ 158785]


Superfamily statistics
Genomes (3,125) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 168,190 406,918 50
Proteins 124,236 317,615 49


Functional annotation
General category General
Detailed category Protein interaction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular component organization or biogenesis0.00076160.0000000002414Least InformativeDirect
Biological Process (BP)positive regulation of biological process11Least InformativeInherited
Biological Process (BP)localization0.44290.7096Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process10.000000000003318Least InformativeInherited
Biological Process (BP)biosynthetic process11Least InformativeInherited
Biological Process (BP)single-organism metabolic process11Least InformativeInherited
Biological Process (BP)protein metabolic process10.00000003357Least InformativeInherited
Biological Process (BP)cellular localization0.00043460.000000001417Moderately InformativeDirect
Biological Process (BP)regulation of developmental process0.11841Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.0054950.0000208Moderately InformativeInherited
Biological Process (BP)single-organism organelle organization0.10520Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.941Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.0091570.4706Moderately InformativeInherited
Biological Process (BP)carbohydrate metabolic process11Moderately InformativeInherited
Biological Process (BP)cellular protein modification process11Moderately InformativeInherited
Biological Process (BP)cellular macromolecule biosynthetic process11Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process11Moderately InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis0.00027591InformativeInherited
Biological Process (BP)regulation of organelle organization0.00460.000201InformativeInherited
Biological Process (BP)positive regulation of cellular component organization0.0013330.1458InformativeInherited
Biological Process (BP)positive regulation of developmental process0.015651InformativeInherited
Biological Process (BP)cell projection organization0.005240.00002581InformativeInherited
Biological Process (BP)organelle fission0.0011830.002566InformativeInherited
Biological Process (BP)single-organism intracellular transport0.0018930InformativeInherited
Biological Process (BP)cellular component movement0.12290.0000946InformativeInherited
Biological Process (BP)microtubule-based process0.041290InformativeInherited
Biological Process (BP)vesicle-mediated transport0.059221InformativeInherited
Biological Process (BP)protein folding0.0000062260Highly InformativeDirect
Biological Process (BP)positive regulation of organelle organization0.000014390.000000707Highly InformativeDirect
Biological Process (BP)cilium organization0.00061560Highly InformativeDirect
Biological Process (BP)regulation of mitochondrion organization0.000000024660.0653Highly InformativeInherited
Biological Process (BP)microtubule-based movement0.005240Highly InformativeInherited
Biological Process (BP)Golgi vesicle transport0.038240.809Highly InformativeInherited
Biological Process (BP)protein glycosylation0.04460.0008305Highly InformativeInherited
Molecular Function (MF)transferase activity11Least InformativeInherited
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)transporter activity11Moderately InformativeInherited
Molecular Function (MF)transferase activity, transferring glycosyl groups0.79730.4252InformativeInherited
Molecular Function (MF)UDP-glycosyltransferase activity0.26320.00395Highly InformativeInherited
Cellular Component (CC)protein complex0.0000017410.0000001697Least InformativeDirect
Cellular Component (CC)intracellular organelle part0.00000017810.000004861Least InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle0.27940.5923Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.34120.1686Least InformativeInherited
Cellular Component (CC)non-membrane-bounded organelle0.090470.002772Least InformativeInherited
Cellular Component (CC)membrane0.44421Least InformativeInherited
Cellular Component (CC)intrinsic component of membrane0.16351Moderately InformativeInherited
Cellular Component (CC)endoplasmic reticulum0.015220.2137Moderately InformativeInherited
Cellular Component (CC)membrane region0.0061951Moderately InformativeInherited
Cellular Component (CC)cytoskeleton0.6390.5607Moderately InformativeInherited
Cellular Component (CC)cell projection0.59610.0000005009Moderately InformativeInherited
Cellular Component (CC)bounding membrane of organelle0.0000000003860.05674Moderately InformativeInherited
Cellular Component (CC)mitochondrial part0.53961Moderately InformativeInherited
Cellular Component (CC)vesicle0.098931Moderately InformativeInherited
Cellular Component (CC)organelle envelope0.29860.8565Moderately InformativeInherited
Cellular Component (CC)endoplasmic reticulum membrane0.000058350.06929InformativeInherited
Cellular Component (CC)microtubule cytoskeleton0.0016220.0003735InformativeInherited
Cellular Component (CC)integral component of membrane0.15671InformativeInherited
Cellular Component (CC)Golgi apparatus0.06541InformativeInherited
Cellular Component (CC)mitochondrial membrane part0.030930.2086InformativeInherited
Cellular Component (CC)Golgi-associated vesicle0.0000001290.000004697Highly InformativeDirect
Cellular Component (CC)intraciliary transport particle0.0004050Highly InformativeDirect
Cellular Component (CC)integral component of organelle membrane0.0000000000033810.00003416Highly InformativeDirect
Cellular Component (CC)organelle outer membrane0.000000094940.00000002939Highly InformativeDirect
Cellular Component (CC)microtubule organizing center0.038870.001176Highly InformativeInherited
Cellular Component (CC)ciliary part0.069350Highly InformativeInherited
Cellular Component (CC)coated vesicle0.000019190.02578Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 0.00000003357 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.000000000003318 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.0000000002414 Least Informative Direct
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) positive regulation of biological process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) localization 0.7096 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) macromolecule localization 0.0000208 Moderately Informative Direct
Biological Process (BP) cellular localization 0.000000001417 Moderately Informative Direct
Biological Process (BP) single-organism organelle organization 0 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.876 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.9256 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.01977 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.108 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.4586 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.4706 Moderately Informative Inherited
Biological Process (BP) reproductive process 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.6846 Moderately Informative Inherited
Biological Process (BP) cellular component movement 0.0000946 Informative Direct
Biological Process (BP) microtubule-based process 0 Informative Direct
Biological Process (BP) protein transport 0.0002136 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0.000137 Informative Direct
Biological Process (BP) cell projection organization 0.00002581 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0.0003833 Informative Direct
Biological Process (BP) regulation of organelle organization 0.000201 Informative Direct
Biological Process (BP) protein localization to organelle 0.000000155 Informative Direct
Biological Process (BP) cellular macromolecular complex assembly 0.000002297 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0.000005505 Informative Direct
Biological Process (BP) cell division 0.000009183 Informative Direct
Biological Process (BP) organelle assembly 0.000109 Informative Direct
Biological Process (BP) single-organism cellular localization 0.0000002796 Informative Direct
Biological Process (BP) single-organism intracellular transport 0 Informative Direct
Biological Process (BP) positive regulation of cellular protein metabolic process 0.4594 Informative Inherited
Biological Process (BP) positive regulation of catabolic process 0.3172 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.01342 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.1458 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 0.8311 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) positive regulation of developmental process 1 Informative Inherited
Biological Process (BP) muscle system process 0.644 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) cell cycle process 0.005392 Informative Inherited
Biological Process (BP) tube development 0.4313 Informative Inherited
Biological Process (BP) blood circulation 0.6211 Informative Inherited
Biological Process (BP) regulation of growth 1 Informative Inherited
Biological Process (BP) regulation of transferase activity 1 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.1709 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.1197 Informative Inherited
Biological Process (BP) organelle localization 1 Informative Inherited
Biological Process (BP) positive regulation of gene expression 1 Informative Inherited
Biological Process (BP) negative regulation of developmental process 1 Informative Inherited
Biological Process (BP) regulation of cell development 1 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) regulation of nervous system development 1 Informative Inherited
Biological Process (BP) actin filament-based process 0.4142 Informative Inherited
Biological Process (BP) cytoskeleton organization 1 Informative Inherited
Biological Process (BP) muscle structure development 0.2436 Informative Inherited
Biological Process (BP) chromosome organization 0.7129 Informative Inherited
Biological Process (BP) response to cytokine 0.4656 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.6205 Informative Inherited
Biological Process (BP) organelle fission 0.002566 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.02599 Informative Inherited
Biological Process (BP) proteolysis 1 Informative Inherited
Biological Process (BP) protein catabolic process 0.06002 Informative Inherited
Biological Process (BP) cellular modified amino acid metabolic process 1 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 0.3904 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.1137 Informative Inherited
Biological Process (BP) protein modification by small protein conjugation or removal 0.3351 Informative Inherited
Biological Process (BP) sexual reproduction 0.7805 Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.06478 Informative Inherited
Biological Process (BP) locomotion 1 Informative Inherited
Biological Process (BP) localization of cell 1 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.742 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) negative regulation of cellular protein metabolic process 0.2691 Informative Inherited
Biological Process (BP) negative regulation of protein processing 1 Informative Inherited
Biological Process (BP) vesicle-mediated transport 1 Informative Inherited
Biological Process (BP) mitochondrion organization 0.1386 Informative Inherited
Biological Process (BP) cytoplasmic transport 1 Informative Inherited
Biological Process (BP) nucleobase-containing compound catabolic process 1 Informative Inherited
Biological Process (BP) multicellular organismal homeostasis 0.5689 Informative Inherited
Biological Process (BP) anatomical structure homeostasis 0.4305 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.176 Informative Inherited
Biological Process (BP) RNA processing 0.03622 Informative Inherited
Biological Process (BP) protein folding 0 Highly Informative Direct
Biological Process (BP) protein methylation 0.0008069 Highly Informative Direct
Biological Process (BP) protein glycosylation 0.0008305 Highly Informative Direct
Biological Process (BP) ubiquitin-dependent protein catabolic process 0.000000646 Highly Informative Direct
Biological Process (BP) microtubule-based movement 0 Highly Informative Direct
Biological Process (BP) chromosome segregation 0.00002294 Highly Informative Direct
Biological Process (BP) positive regulation of organelle organization 0.000000707 Highly Informative Direct
Biological Process (BP) cellular component assembly involved in morphogenesis 0.000000000000003707 Highly Informative Direct
Biological Process (BP) gene silencing 0.00006646 Highly Informative Direct
Biological Process (BP) histone modification 0.0003454 Highly Informative Direct
Biological Process (BP) protein import 0.0005008 Highly Informative Direct
Biological Process (BP) peptidyl-proline modification 0 Highly Informative Direct
Biological Process (BP) cell projection assembly 0.00000000104 Highly Informative Direct
Biological Process (BP) collagen metabolic process 0.000785 Highly Informative Direct
Biological Process (BP) cilium organization 0 Highly Informative Direct
Biological Process (BP) maintenance of location 0.0002176 Highly Informative Direct
Biological Process (BP) regulation of ligase activity 0.00001671 Highly Informative Direct
Biological Process (BP) protein localization to mitochondrion 0.0005659 Highly Informative Direct
Biological Process (BP) regulation of proteolysis involved in cellular protein catabolic process 0.00000000000005349 Highly Informative Direct
Biological Process (BP) positive regulation of protein modification by small protein conjugation or removal 0.0005514 Highly Informative Direct
Biological Process (BP) positive regulation of mitotic cell cycle 0.02112 Highly Informative Inherited
Biological Process (BP) positive regulation of cell cycle process 0.07683 Highly Informative Inherited
Biological Process (BP) regulation of cellular ketone metabolic process 0.04519 Highly Informative Inherited
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.6285 Highly Informative Inherited
Biological Process (BP) carbohydrate homeostasis 0.7798 Highly Informative Inherited
Biological Process (BP) regulation of mitochondrion organization 0.0653 Highly Informative Inherited
Biological Process (BP) actin filament-based movement 0.1187 Highly Informative Inherited
Biological Process (BP) heart contraction 0.005028 Highly Informative Inherited
Biological Process (BP) response to ionizing radiation 0.9379 Highly Informative Inherited
Biological Process (BP) cellular response to radiation 0.01922 Highly Informative Inherited
Biological Process (BP) negative regulation of mitotic cell cycle phase transition 1 Highly Informative Inherited
Biological Process (BP) spindle checkpoint 0.001519 Highly Informative Inherited
Biological Process (BP) protein ubiquitination 0.0555 Highly Informative Inherited
Biological Process (BP) striated muscle contraction 0.009915 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 1 Highly Informative Inherited
Biological Process (BP) regulation of protein ubiquitination 0.03611 Highly Informative Inherited
Biological Process (BP) negative regulation of transferase activity 0.02878 Highly Informative Inherited
Biological Process (BP) positive regulation of cell division 0.00647 Highly Informative Inherited
Biological Process (BP) regulation of nuclear division 0.005214 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0.9326 Highly Informative Inherited
Biological Process (BP) negative regulation of nervous system development 0.06924 Highly Informative Inherited
Biological Process (BP) actomyosin structure organization 0.003117 Highly Informative Inherited
Biological Process (BP) internal protein amino acid acetylation 1 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 1 Highly Informative Inherited
Biological Process (BP) cell projection morphogenesis 0.353 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 0.8846 Highly Informative Inherited
Biological Process (BP) DNA replication 0.01585 Highly Informative Inherited
Biological Process (BP) proteasomal protein catabolic process 0.09808 Highly Informative Inherited
Biological Process (BP) peptidyl-lysine modification 0.8393 Highly Informative Inherited
Biological Process (BP) regulation of gene expression, epigenetic 0.006033 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.7411 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.1408 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.02022 Highly Informative Inherited
Biological Process (BP) germ cell development 0.3209 Highly Informative Inherited
Biological Process (BP) epithelial cell development 0.3974 Highly Informative Inherited
Biological Process (BP) columnar/cuboidal epithelial cell differentiation 0.1385 Highly Informative Inherited
Biological Process (BP) negative regulation of cellular catabolic process 0.05306 Highly Informative Inherited
Biological Process (BP) negative regulation of protein catabolic process 0.5351 Highly Informative Inherited
Biological Process (BP) negative regulation of cell division 0.1928 Highly Informative Inherited
Biological Process (BP) negative regulation of chromosome organization 0.1593 Highly Informative Inherited
Biological Process (BP) nuclear division 0.0747 Highly Informative Inherited
Biological Process (BP) Golgi vesicle transport 0.809 Highly Informative Inherited
Biological Process (BP) mitochondrial transport 0.0143 Highly Informative Inherited
Biological Process (BP) RNA splicing 0.00246 Highly Informative Inherited
Biological Process (BP) mRNA catabolic process 0.02211 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) isomerase activity 0.0003337 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) structural molecule activity 0.9544 Moderately Informative Inherited
Molecular Function (MF) enzyme regulator activity 0.6696 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 0.4252 Informative Inherited
Molecular Function (MF) nucleotidyltransferase activity 0.001545 Informative Inherited
Molecular Function (MF) transferase activity, transferring one-carbon groups 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 0.686 Informative Inherited
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 1 Informative Inherited
Molecular Function (MF) enzyme inhibitor activity 0.06458 Informative Inherited
Molecular Function (MF) enzyme binding 0.2027 Informative Inherited
Molecular Function (MF) protein complex binding 1 Informative Inherited
Molecular Function (MF) amide binding 0.00315 Informative Inherited
Molecular Function (MF) ubiquitin-protein transferase activity 0.0001018 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 0.000000002209 Highly Informative Direct
Molecular Function (MF) dioxygenase activity 0.000000000000002376 Highly Informative Direct
Molecular Function (MF) adenylyltransferase activity 0.000000000012 Highly Informative Direct
Molecular Function (MF) methyltransferase activity 0.9981 Highly Informative Inherited
Molecular Function (MF) acetyltransferase activity 0.003946 Highly Informative Inherited
Molecular Function (MF) UDP-glycosyltransferase activity 0.00395 Highly Informative Inherited
Molecular Function (MF) transferase activity, transferring hexosyl groups 0.3509 Highly Informative Inherited
Molecular Function (MF) protein transporter activity 0.008887 Highly Informative Inherited
Molecular Function (MF) drug binding 0.003726 Highly Informative Inherited
Molecular Function (MF) protein kinase regulator activity 0.3327 Highly Informative Inherited
Molecular Function (MF) peptide binding 0.001576 Highly Informative Inherited
Cellular Component (CC) protein complex 0.0000001697 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.000004861 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.5923 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.002772 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.1686 Least Informative Inherited
Cellular Component (CC) cell projection 0.0000005009 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.0000000003835 Moderately Informative Direct
Cellular Component (CC) transferase complex 0.000003445 Moderately Informative Direct
Cellular Component (CC) intrinsic component of membrane 1 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.2137 Moderately Informative Inherited
Cellular Component (CC) membrane region 1 Moderately Informative Inherited
Cellular Component (CC) bounding membrane of organelle 0.05674 Moderately Informative Inherited
Cellular Component (CC) mitochondrial part 1 Moderately Informative Inherited
Cellular Component (CC) vesicle 1 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.3404 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.5607 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 0.8565 Moderately Informative Inherited
Cellular Component (CC) ubiquitin ligase complex 0.000000000002774 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 0.0003735 Informative Direct
Cellular Component (CC) endoplasmic reticulum membrane 0.06929 Informative Inherited
Cellular Component (CC) microbody 0.02359 Informative Inherited
Cellular Component (CC) chromosome 0.0374 Informative Inherited
Cellular Component (CC) integral component of membrane 1 Informative Inherited
Cellular Component (CC) Golgi apparatus 1 Informative Inherited
Cellular Component (CC) nucleoplasm part 1 Informative Inherited
Cellular Component (CC) DNA-directed RNA polymerase complex 0.1965 Informative Inherited
Cellular Component (CC) oxidoreductase complex 0.0726 Informative Inherited
Cellular Component (CC) mitochondrial membrane part 0.2086 Informative Inherited
Cellular Component (CC) nuclear ubiquitin ligase complex 0 Highly Informative Direct
Cellular Component (CC) Golgi-associated vesicle 0.000004697 Highly Informative Direct
Cellular Component (CC) intraciliary transport particle 0 Highly Informative Direct
Cellular Component (CC) integral component of organelle membrane 0.00003416 Highly Informative Direct
Cellular Component (CC) organelle outer membrane 0.00000002939 Highly Informative Direct
Cellular Component (CC) ciliary part 0 Highly Informative Direct
Cellular Component (CC) microtubule organizing center 0.001176 Highly Informative Inherited
Cellular Component (CC) chromatin 0.01552 Highly Informative Inherited
Cellular Component (CC) protein acetyltransferase complex 0.00276 Highly Informative Inherited
Cellular Component (CC) coated vesicle 0.02578 Highly Informative Inherited
Cellular Component (CC) microtubule associated complex 0.6783 Highly Informative Inherited
Cellular Component (CC) nuclear chromosome part 1 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Isomerases0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0.5472Least InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases0.003141Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups0.5544Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases0.1413Least InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.0012Moderately InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0.002744Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases0.3264Moderately InformativeInherited
Enzyme Commission (EC)Methyltransferases0.1514Moderately InformativeInherited
Enzyme Commission (EC)Peptidylprolyl isomerase0InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase0.000000000004361InformativeDirect
Enzyme Commission (EC)Phosphoprotein phosphatase0.000000007897InformativeDirect
Enzyme Commission (EC)With 2-oxoglutarate as one donor, and incorporatio0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)genetic disease0.7939Moderately InformativeInherited
Disease Ontology (DO)autosomal recessive disease0.3702InformativeInherited
Disease Ontology (DO)Bardet-Biedl syndrome0.0002925Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.008701Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.3001Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the globe0.0001946Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of digit0.09247Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of brain morphology0.2717Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal genital system morphology0.422Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of male external genitalia0.0003368InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the fundus0.006142InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cerebral ventricles0.05458InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lens0.1016InformativeInherited
Phenotypic Abnormality (PA)Postaxial polydactyly0.0002015Highly InformativeDirect
Phenotypic Abnormality (PA)Cataract0.0002736Highly InformativeDirect
Phenotypic Abnormality (PA)Ventriculomegaly0.0007048Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.3854Least InformativeInherited
Mammalian Phenotype (MP)renal/urinary system phenotype0.1516Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell morphology0.00312InformativeInherited
Mammalian Phenotype (MP)abnormal primary cilium morphology0.08497Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.002705Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.007132Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.05727Least InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.0001758Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0.0005997Moderately InformativeDirect
Worm Phenotype (WP)gametogenesis variant0.02152Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.02421Moderately InformativeInherited
Worm Phenotype (WP)cell organization biogenesis variant0.109Moderately InformativeInherited
Worm Phenotype (WP)sensillum morphology variant0.0000001182InformativeDirect
Worm Phenotype (WP)chemotaxis variant0.00002538InformativeDirect
Worm Phenotype (WP)embryonic cell organization biogenesis variant0.0001813InformativeDirect
Worm Phenotype (WP)mechanosensation variant0.003694InformativeInherited
Worm Phenotype (WP)male morphology variant0.007713InformativeInherited
Worm Phenotype (WP)copulation variant0.02665InformativeInherited
Worm Phenotype (WP)male behavior variant1InformativeInherited
Worm Phenotype (WP)mitotic spindle defective early emb0.000009735Highly InformativeDirect
Worm Phenotype (WP)dauer development variant0.0003135Highly InformativeDirect
Worm Phenotype (WP)dauer arrest variant0.0003952Highly InformativeDirect
Worm Phenotype (WP)nuclear number variant0.0007523Highly InformativeDirect
Worm Phenotype (WP)male nervous system morphology variant0.0008091Highly InformativeDirect
Worm Phenotype (WP)pronucleus centrosomes defective early emb0.001248Highly InformativeInherited
Worm Phenotype (WP)cell cycle variant0.00489Highly InformativeInherited
Worm Phenotype (WP)touch resistant0.1792Highly InformativeInherited

Document: WP annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)seed0.00000001344Least InformativeDirect
Plant ANatomical entity (PAN)whole plant0.04157Least InformativeInherited
Plant ANatomical entity (PAN)shoot axis0.1729Least InformativeInherited
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0.00004524Least InformativeDirect
Plant structure DEvelopment stage (PDE)0 seed germination stage0InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0.0006577Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases0.1096Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Isomerases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.0009247Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.002565Moderately InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases0.004582Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases0.3618Moderately InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups0.5475Moderately InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen0InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase0.000000000002228InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0.000002576InformativeDirect
Enzyme Commission (EC)Hexosyltransferases0.004819InformativeInherited
Enzyme Commission (EC)Phosphorus-oxygen lyases1InformativeInherited
Enzyme Commission (EC)With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors0Highly InformativeDirect
Enzyme Commission (EC)Peptidylprolyl isomerase0Highly InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine phosphatase0.000000004274Highly InformativeDirect
Enzyme Commission (EC)Adenylate cyclase0.0000007042Highly InformativeDirect

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)sensory organs0.009348Least InformativeInherited
Drugbank ATC_code (DB)alimentary tract and metabolism0.1317Least InformativeInherited
Drugbank ATC_code (DB)genito urinary system and sex hormones0.0006791Moderately InformativeDirect
Drugbank ATC_code (DB)ascorbic acid (vitamin c), incl. combinations0.0000008457InformativeDirect
Drugbank ATC_code (DB)ascorbic acid0.0000008457InformativeDirect
Drugbank ATC_code (DB)ascorbic acid0.0000008457InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processProtein transport0Moderately InformativeDirect
Biological processDifferentiation0.00000000001349Moderately InformativeDirect
Biological processCell cycle0.00001139Moderately InformativeDirect
Biological processApoptosis0.00004352Moderately InformativeDirect
Biological processMitosis0InformativeDirect
Biological processPhotosynthesis0InformativeDirect
Biological processUbl conjugation pathway0InformativeDirect
Biological processNeurogenesis0.000000145InformativeDirect
Biological processInnate immunity0.000001227InformativeDirect
Biological processMeiosis0.00002837InformativeDirect
Biological processmRNA splicing0.00007795InformativeDirect
Biological processER-Golgi transport0Highly InformativeDirect
Biological processCilium biogenesis/degradation0Highly InformativeDirect
Biological processRNA-mediated gene silencing0.000000000004865Highly InformativeDirect
Biological processMyogenesis0.000000002118Highly InformativeDirect
Biological processChromosome partition0.00000000747Highly InformativeDirect
Biological processNonsense-mediated mRNA decay0.0000001023Highly InformativeDirect
Biological processAntiviral defense0.0000007968Highly InformativeDirect
Biological processUnfolded protein response0.000003421Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentPlastid0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentMitochondrion0.000000000000006951Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0.000005554Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.00002914Moderately InformativeDirect
Cellular componentMicrotubule0InformativeDirect
Cellular componentSpliceosome0InformativeDirect
Cellular componentThylakoid0InformativeDirect
Cellular componentMitochondrion outer membrane0InformativeDirect
Cellular componentPeroxisome0.000000000001892InformativeDirect
Cellular componentCell outer membrane0.000004035InformativeDirect
Cellular componentCilium0Highly InformativeDirect
Cellular componentProteasome0.00003786Highly InformativeDirect
Coding sequence diversityAlternative splicing0.0006727Least InformativeDirect
DiseaseCiliopathy0.000000007593InformativeDirect
DomainRepeat0Least InformativeDirect
DomainTPR repeat0Highly InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationActivator0.00000009092Moderately InformativeDirect
Post-translational modificationIsomerase0.798Moderately InformativeInherited
Post-translational modificationOxidoreductase1Moderately InformativeInherited
Post-translational modificationChaperone0.0000001692InformativeDirect
Post-translational modificationProtein phosphatase0.0000004131InformativeDirect
Post-translational modificationChromatin regulator0.000004658InformativeDirect
Post-translational modificationInitiation factor0.000007224InformativeDirect
Post-translational modificationRotamase0Highly InformativeDirect
Post-translational modificationDioxygenase0.00000000000003311Highly InformativeDirect
Post-translational modificationAcetylation0Least InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation0.00003849Moderately InformativeDirect
Post-translational modificationPalmitate0.0004483Moderately InformativeDirect
Post-translational modificationThioester bond0Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)glycan metabolism0.00000008814Moderately InformativeDirect
UniPathway (UP)cellulose metabolism0.000000000003507InformativeDirect
UniPathway (UP)bacterial cellulose biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 29 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a TPR-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 29 hidden Markov models representing the TPR-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]