SUPERFAMILY 1.75 HMM library and genome assignments server

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TPR-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   alpha-alpha superhelix [ 48370] (24)
Superfamily:   TPR-like [ 48452] (8)
Families:   Tetratricopeptide repeat (TPR) [ 48453] (17)
  Transcription factor MalT domain III [ 69094]
  BTAD-like [ 140845]
  PrgX C-terminal domain-like [ 140848]
  Atu0120-like [ 158772]
  SusD-like [ 158775] (3)
  HAT/Suf repeat [ 158782]
  CT2138-like [ 158785]


Superfamily statistics
Genomes (3,133) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 169,526 955,257 50
Proteins 125,432 730,800 49


Functional annotation
General category General
Detailed category Protein interaction

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Isomerases0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0.5472Least InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases0.003141Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups0.5544Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases0.1413Least InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.0012Moderately InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0.002744Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases0.3264Moderately InformativeInherited
Enzyme Commission (EC)Methyltransferases0.1514Moderately InformativeInherited
Enzyme Commission (EC)Peptidylprolyl isomerase0InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase0.000000000004361InformativeDirect
Enzyme Commission (EC)Phosphoprotein phosphatase0.000000007897InformativeDirect
Enzyme Commission (EC)With 2-oxoglutarate as one donor, and incorporatio0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)genetic disease0.7219Moderately InformativeInherited
Disease Ontology (DO)autosomal recessive disease0.3353InformativeInherited
Disease Ontology (DO)Bardet-Biedl syndrome0.0002735Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of limbs0.3254Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.439Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.5113Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.5418Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.745Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.3203Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limb bone morphology0.4273Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system morphology0.4469Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper urinary tract0.4702Moderately InformativeInherited
Phenotypic Abnormality (PA)Nephronophthisis0.0004334Highly InformativeDirect
Phenotypic Abnormality (PA)Polydactyly0.02699Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.1089Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal kidney epithelium morphology0.0008495Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organ system morphology variant0.0000001463Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.0000007008Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0.000001423Least InformativeDirect
Worm Phenotype (WP)cell development variant0.006855Least InformativeInherited
Worm Phenotype (WP)blast cell physiology variant0.006918Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.006963Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.03949Least InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.0002384Moderately InformativeDirect
Worm Phenotype (WP)germ cell development variant0.002225Moderately InformativeInherited
Worm Phenotype (WP)body region morphology variant0.02506Moderately InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.02506Moderately InformativeInherited
Worm Phenotype (WP)developmental morphology variant0.02526Moderately InformativeInherited
Worm Phenotype (WP)adult body morphology variant0.02545Moderately InformativeInherited
Worm Phenotype (WP)body morphology variant0.03058Moderately InformativeInherited
Worm Phenotype (WP)drug response variant0.04183Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.09847Moderately InformativeInherited
Worm Phenotype (WP)nervous system morphology variant0.103Moderately InformativeInherited
Worm Phenotype (WP)cell organization biogenesis variant0.2502Moderately InformativeInherited
Worm Phenotype (WP)reproductive system development variant0.3479Moderately InformativeInherited
Worm Phenotype (WP)sensillum morphology variant0.00000002407InformativeDirect
Worm Phenotype (WP)male morphology variant0.00008815InformativeDirect
Worm Phenotype (WP)embryonic cell organization biogenesis variant0.0003788InformativeDirect
Worm Phenotype (WP)somatic gonad development variant0.0004088InformativeDirect
Worm Phenotype (WP)pesticide response variant0.001482InformativeInherited
Worm Phenotype (WP)mechanosensation variant0.01074InformativeInherited
Worm Phenotype (WP)drug resistant0.02343InformativeInherited
Worm Phenotype (WP)positive chemotaxis variant0.0741InformativeInherited
Worm Phenotype (WP)neuron morphology variant0.4394InformativeInherited
Worm Phenotype (WP)antihelmintic response variant0.00001404Highly InformativeDirect
Worm Phenotype (WP)dauer development variant0.0004284Highly InformativeDirect
Worm Phenotype (WP)nuclear number variant0.0004471Highly InformativeDirect
Worm Phenotype (WP)division axis defective0.009823Highly InformativeInherited
Worm Phenotype (WP)touch resistant0.3011Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)nervous system0.6845Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.9685Least InformativeInherited
Fly Anatomy (FA)adult1Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.1855Moderately InformativeInherited
Fly Anatomy (FA)head0.8908Moderately InformativeInherited
Fly Anatomy (FA)adult segment0.9108Moderately InformativeInherited
Fly Anatomy (FA)adult nervous system1Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system1Moderately InformativeInherited
Fly Anatomy (FA)nerve0.1779InformativeInherited
Fly Anatomy (FA)adult procephalic segment0.4531InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)embryonic structure0.09757InformativeInherited

Document: ZA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)seed0.00000001357Least InformativeDirect
Plant ANatomical entity (PAN)whole plant0.04222Least InformativeInherited
Plant ANatomical entity (PAN)shoot axis0.1747Least InformativeInherited
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0.00004502Least InformativeDirect
Plant structure DEvelopment stage (PDE)0 seed germination stage0InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0.04718Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases0.4854Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Isomerases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0.0000001048Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.0000002425Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.001503Moderately InformativeInherited
Enzyme Commission (EC)Aminoacyltransferases0.002097Moderately InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases0.06587Moderately InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Moderately InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0InformativeDirect
Enzyme Commission (EC)Hexosyltransferases0InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0.000000000001399InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase0.00000000001779InformativeDirect
Enzyme Commission (EC)RING-type E3 ubiquitin transferase0.00004557InformativeDirect
Enzyme Commission (EC)Phosphorus-oxygen lyases1InformativeInherited
Enzyme Commission (EC)With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors0Highly InformativeDirect
Enzyme Commission (EC)Peptidylprolyl isomerase0Highly InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine phosphatase0.00000000254Highly InformativeDirect
Enzyme Commission (EC)Adenylate cyclase0.000001944Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 51 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a TPR-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 51 hidden Markov models representing the TPR-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]