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TPR-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   alpha-alpha superhelix [ 48370] (24)
Superfamily:   TPR-like [ 48452] (8)
Families:   Tetratricopeptide repeat (TPR) [ 48453] (17)
  Transcription factor MalT domain III [ 69094]
  BTAD-like [ 140845]
  PrgX C-terminal domain-like [ 140848]
  Atu0120-like [ 158772]
  SusD-like [ 158775] (3)
  HAT/Suf repeat [ 158782]
  CT2138-like [ 158785]


Superfamily statistics
Genomes (3,133) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 169,526 955,257 50
Proteins 125,432 730,800 49


Functional annotation
General category General
Detailed category Protein interaction

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Isomerases0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0.5472Least InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases0.003141Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups0.5544Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases0.1413Least InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.0012Moderately InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0.002744Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases0.3264Moderately InformativeInherited
Enzyme Commission (EC)Methyltransferases0.1514Moderately InformativeInherited
Enzyme Commission (EC)Peptidylprolyl isomerase0InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase0.000000000004361InformativeDirect
Enzyme Commission (EC)Phosphoprotein phosphatase0.000000007897InformativeDirect
Enzyme Commission (EC)With 2-oxoglutarate as one donor, and incorporatio0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)genetic disease0.7217Moderately InformativeInherited
Disease Ontology (DO)autosomal recessive disease0.3352InformativeInherited
Disease Ontology (DO)Bardet-Biedl syndrome0.0002733Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the skeletal system0.1668Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.2049Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.2997Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.5988Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.7808Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limb bone morphology0.1546Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.2721Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system morphology0.3439Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the urinary system0.8144Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal renal morphology0.1312InformativeInherited
Phenotypic Abnormality (PA)Nephronophthisis0.0004446Highly InformativeDirect
Phenotypic Abnormality (PA)Hepatic fibrosis0.0007726Highly InformativeDirect
Phenotypic Abnormality (PA)Postaxial polydactyly0.0008292Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.1089Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal kidney epithelium morphology0.0009196Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organ system morphology variant0.0000000112Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.0000001126Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0.0004774Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.007213Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.01727Least InformativeInherited
Worm Phenotype (WP)cell development variant0.03221Least InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.00003949Moderately InformativeDirect
Worm Phenotype (WP)chemical response variant0.01893Moderately InformativeInherited
Worm Phenotype (WP)gametogenesis variant0.03274Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.09122Moderately InformativeInherited
Worm Phenotype (WP)nervous system morphology variant0.1205Moderately InformativeInherited
Worm Phenotype (WP)reproductive system development variant0.2406Moderately InformativeInherited
Worm Phenotype (WP)cell component morphology variant0.3832Moderately InformativeInherited
Worm Phenotype (WP)sensillum morphology variant0.00000001274InformativeDirect
Worm Phenotype (WP)embryonic cell organization biogenesis variant0.0003174InformativeDirect
Worm Phenotype (WP)somatic gonad development variant0.0004585InformativeDirect
Worm Phenotype (WP)male morphology variant0.000531InformativeDirect
Worm Phenotype (WP)dauer arrest variant0.02018InformativeInherited
Worm Phenotype (WP)positive chemotaxis variant0.09968InformativeInherited
Worm Phenotype (WP)mitotic spindle defective early emb0.00001963Highly InformativeDirect
Worm Phenotype (WP)pronucleus centrosomes defective early emb0.0002726Highly InformativeDirect
Worm Phenotype (WP)dauer development variant0.0004504Highly InformativeDirect
Worm Phenotype (WP)multiple nuclei0.0007178Highly InformativeDirect
Worm Phenotype (WP)cell cycle variant0.01866Highly InformativeInherited
Worm Phenotype (WP)touch resistant0.3182Highly InformativeInherited

Document: WP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)embryonic structure0.07184Highly InformativeInherited

Document: ZA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)seed0.00000001357Least InformativeDirect
Plant ANatomical entity (PAN)whole plant0.04222Least InformativeInherited
Plant ANatomical entity (PAN)shoot axis0.1747Least InformativeInherited
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0.00004502Least InformativeDirect
Plant structure DEvelopment stage (PDE)0 seed germination stage0InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0.001062Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases0.4025Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Isomerases0Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.0000002427Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.0008153Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0.02308Moderately InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases0.06611Moderately InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups0.868Moderately InformativeInherited
Enzyme Commission (EC)Acyltransferases0.9186Moderately InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0.0000000000003255InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase0.00000000001603InformativeDirect
Enzyme Commission (EC)Hexosyltransferases0.00000008593InformativeDirect
Enzyme Commission (EC)RING-type E3 ubiquitin transferase0.0000244InformativeDirect
Enzyme Commission (EC)Phosphorus-oxygen lyases1InformativeInherited
Enzyme Commission (EC)With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors0Highly InformativeDirect
Enzyme Commission (EC)Peptidylprolyl isomerase0Highly InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine phosphatase0.000000001186Highly InformativeDirect
Enzyme Commission (EC)Adenylate cyclase0.00000137Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 51 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a TPR-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 51 hidden Markov models representing the TPR-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]