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Tetracyclin repressor-like, C-terminal domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Tetracyclin repressor-like, C-terminal domain [ 48497]
Superfamily:   Tetracyclin repressor-like, C-terminal domain [ 48498]
Families:   Tetracyclin repressor-like, C-terminal domain [ 48499] (34)


Superfamily statistics
Genomes (1,935) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 25,962 201,023 47
Proteins 25,935 200,742 47


Functional annotation
General category Information
Detailed category Transcription

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biological regulation 0.000000003032 Least Informative Direct
Biological Process (BP) negative regulation of metabolic process 0.00004461 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.0008479 Moderately Informative Direct
Biological Process (BP) negative regulation of macromolecule biosynthetic process 0.00002524 Informative Direct
Biological Process (BP) negative regulation of gene expression 0.0003468 Informative Direct
Biological Process (BP) negative regulation of cellular biosynthetic process 0.00005915 Informative Direct
Biological Process (BP) negative regulation of RNA metabolic process 0.000002369 Highly Informative Direct
Molecular Function (MF) binding 0.00008242 Least Informative Direct
Molecular Function (MF) nucleic acid binding 0 Moderately Informative Direct
Molecular Function (MF) DNA binding 0 Informative Direct
Molecular Function (MF) transcription factor activity, sequence-specific DNA binding 0 Informative Direct
Molecular Function (MF) identical protein binding 0.0003389 Informative Direct
Cellular Component (CC) protein-DNA complex 0 Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCell cycle0Moderately InformativeDirect
Biological processTranscription regulation0Moderately InformativeDirect
Biological processAntibiotic resistance0.000001755InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
Post-translational modificationDNA-binding0Moderately InformativeDirect
Post-translational modificationRepressor0Moderately InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR011075 SSF48498 Protein matches
Abstract

This entry represents the C-terminal domain found in a number of different TetR transcription regulator proteins. TetR regulates the expression of the membrane-associated tetracycline resistance protein, TetA, which exports the tetracycline antibiotic out of the cell before it can attach to the ribosomes and inhibit protein synthesis [PubMed7707374]. TetR blocks transcription from the genes encoding both TetA and TetR in the absence of antibiotic. The C-terminal domain is multi-helical and is interlocked in the homodimer with the helix-turn-helix (HTH) DNA-binding domain. Other members of the TetR family of transcriptional regulators carry this C-terminal domain. These include:

  • QacR from Staphylococcus aureus, a multidrug binding protein that represses transcription of the qacA multidrug transporter gene [PubMed11739955]
  • Ethr, a repressor from Mycobacterium tuberculosis implicated in ethionamide drug resistance [PubMed15236969]
  • CprB, a gamma-butyrolactone autoregulator/receptor from Streptomyces coelicolor that acts as a DNA-binding protein [PubMed14757054]
  • YcdC, a hypothetical transcriptional regulator from Escherichia coli
  • YsiA, YfiR, and YxaF, hypothetical transcriptional regulators from Bacillus subtilis
  • YbiH, a hypothetical transcriptional regulator from Salmonella typhimurium


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 34 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Tetracyclin repressor-like, C-terminal domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 34 hidden Markov models representing the Tetracyclin repressor-like, C-terminal domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]