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Serum albumin-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Serum albumin-like [ 48551]
Superfamily:   Serum albumin-like [ 48552]
Families:   Serum albumin-like [ 48553] (2)


Superfamily statistics
Genomes (68) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 884 1,878 31
Proteins 332 732 11


Functional annotation
General category General
Detailed category General

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0.0006281 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.2076 Least Informative Inherited
Biological Process (BP) biological regulation 0.004635 Least Informative Inherited
Biological Process (BP) multi-organism process 0.000000006454 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.0000004689 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0.0000005792 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.0000006613 Moderately Informative Direct
Biological Process (BP) cell communication 0.0000009018 Moderately Informative Direct
Biological Process (BP) response to external stimulus 0.000004122 Moderately Informative Direct
Biological Process (BP) cellular localization 0.002671 Moderately Informative Inherited
Biological Process (BP) response to extracellular stimulus 0 Informative Direct
Biological Process (BP) organelle localization 0 Informative Direct
Biological Process (BP) regulation of apoptotic process 0.0000000000009054 Informative Direct
Biological Process (BP) negative regulation of cell death 0.000000005371 Informative Direct
Biological Process (BP) interspecies interaction between organisms 0.00000004774 Informative Direct
Biological Process (BP) single-organism cellular localization 0.000002139 Informative Direct
Biological Process (BP) negative regulation of apoptotic process 0 Highly Informative Direct
Biological Process (BP) response to nutrient levels 0 Highly Informative Direct
Biological Process (BP) multi-organism cellular process 0 Highly Informative Direct
Biological Process (BP) modification of morphology or physiology of other organism involved in symbiotic interaction 0 Highly Informative Direct
Biological Process (BP) killing of cells of other organism 0 Highly Informative Direct
Biological Process (BP) maintenance of location 0 Highly Informative Direct
Biological Process (BP) cellular response to extracellular stimulus 0.00000000000001597 Highly Informative Direct
Molecular Function (MF) binding 0.00002021 Least Informative Direct
Molecular Function (MF) small molecule binding 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.00000000001759 Moderately Informative Direct
Molecular Function (MF) nucleic acid binding 0.6041 Moderately Informative Inherited
Molecular Function (MF) carboxylic acid binding 0.000000000003815 Informative Direct
Molecular Function (MF) DNA binding 0.0000000007104 Informative Direct
Molecular Function (MF) vitamin binding 0 Highly Informative Direct
Molecular Function (MF) monocarboxylic acid binding 0 Highly Informative Direct
Molecular Function (MF) drug binding 0 Highly Informative Direct
Cellular Component (CC) protein complex 0.0000003134 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.02946 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.5213 Least Informative Inherited
Cellular Component (CC) extracellular region part 0.0000000004711 Moderately Informative Direct
Cellular Component (CC) endomembrane system 0.00004872 Moderately Informative Direct
Cellular Component (CC) extracellular space 0.0000000000008089 Informative Direct
Cellular Component (CC) Golgi apparatus 0.0000003318 Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentSecreted0Moderately InformativeDirect
DiseaseAllergen0.00006625Moderately InformativeDirect
DomainRepeat0Least InformativeDirect
DomainSignal0Least InformativeDirect
Molecular functionMetal-binding0.00000001246Least InformativeDirect
Molecular functionZinc0.00003145Least InformativeDirect
Molecular functionLipid-binding0Moderately InformativeDirect
Molecular functionCopper0InformativeDirect
Molecular functionNickel0.00000000000003147InformativeDirect
Post-translational modificationActin-binding0.00000008215InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationGlycoprotein0.00004437Least InformativeDirect
Post-translational modificationCleavage on pair of basic residues0Moderately InformativeDirect
Post-translational modificationMethylation0.00000001035Moderately InformativeDirect
Post-translational modificationSulfation0InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR000264 SSF48552 Protein matches
Abstract A number of serum transport proteins are known to be evolutionarily related, including albumin, alpha-fetoprotein, vitamin D-binding protein and afamin [PubMed2481749, PubMed2423133, PubMed7517938]. Albumin is the main protein of plasma; it binds water, cations (such as Ca2+, Na+ and K+), fatty acids, hormones, bilirubin and drugs - its main function is to regulate the colloidal osmotic pressure of blood. Alphafeto- protein (alpha-fetoglobulin) is a foetal plasma protein that binds various cations, fatty acids and bilirubin. Vitamin D-binding protein binds to vitamin D and its metabolites, as well as to fatty acids. The biological role of afamin (alpha-albumin) has not yet been characterised. The 3D structure of human serum albumin has been determined by X-ray crystallography to a resolution of 2.8A [PubMed1630489]. It comprises three homologous domains that assemble to form a heart-shaped molecule [PubMed1630489]. Each domain is a product of two subdomains that possess common structural motifs [PubMed1630489]. The principal regions of ligand binding to human serum albumin are located in hydrophobic cavities in subdomains IIA and IIIA, which exhibit similar chemistry. Structurally, the serum albumins are similar, each domain containing five or six internal disulphide bonds, as shown schematically below:
                    +---+          +----+                        +-----+
                    |   |          |    |                        |     |
 xxCxxxxxxxxxxxxxxxxCCxxCxxxxCxxxxxCCxxxCxxxxxxxxxCxxxxxxxxxxxxxxCCxxxxCxxxx
   |                 |       |     |              |               |
   +-----------------+       +-----+              +---------------+

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 6 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Serum albumin-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 6 hidden Markov models representing the Serum albumin-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]