SUPERFAMILY 1.75 HMM library and genome assignments server


L-aspartase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   L-aspartase-like [ 48556]
Superfamily:   L-aspartase-like [ 48557] (2)
Families:   L-aspartase/fumarase [ 48558] (5)
  HAL/PAL-like [ 48572] (2)


Superfamily statistics
Genomes (2,408) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 10,185 31,038 34
Proteins 10,112 31,005 34


Functional annotation
General category Metabolism
Detailed category Amino acids metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)nitrogen compound metabolic process8.953e-051.821e-05Least InformativeDirect
Biological Process (BP)single-organism metabolic process3.458e-104.008e-15Least InformativeDirect
Biological Process (BP)cellular aromatic compound metabolic process10.9504Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process10.9117Least InformativeInherited
Biological Process (BP)response to stimulus0.32970.9092Least InformativeInherited
Biological Process (BP)protein metabolic process11Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process11Least InformativeInherited
Biological Process (BP)biosynthetic process0.035620.02805Least InformativeInherited
Biological Process (BP)heterocycle metabolic process10.9868Least InformativeInherited
Biological Process (BP)cellular amino acid metabolic process2.002e-080Moderately InformativeDirect
Biological Process (BP)organonitrogen compound biosynthetic process5.36e-051.334e-05Moderately InformativeDirect
Biological Process (BP)carbohydrate derivative metabolic process0.28340.3342Moderately InformativeInherited
Biological Process (BP)nucleobase-containing small molecule metabolic process0.25520.2594Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process0.032960.0483Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process0.015670.05739Moderately InformativeInherited
Biological Process (BP)cellular nitrogen compound biosynthetic process0.00025130.009319Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process0.017670.04967Moderately InformativeInherited
Biological Process (BP)small molecule biosynthetic process11Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.16940.6774Moderately InformativeInherited
Biological Process (BP)organophosphate metabolic process0.053460.07313Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.02340.07929Moderately InformativeInherited
Biological Process (BP)oxidation-reduction process0.12890.4146Moderately InformativeInherited
Biological Process (BP)purine nucleotide metabolic process6.54e-077.523e-07InformativeDirect
Biological Process (BP)glutamine family amino acid metabolic process3.85e-114.997e-09InformativeDirect
Biological Process (BP)nucleotide biosynthetic process1.423e-094.063e-09InformativeDirect
Biological Process (BP)energy derivation by oxidation of organic compounds7.265e-081.243e-07InformativeDirect
Biological Process (BP)ribose phosphate metabolic process4.687e-055.67e-05InformativeDirect
Biological Process (BP)single-organism behavior1.089e-050.0007371InformativeDirect
Biological Process (BP)purine-containing compound biosynthetic process1.621e-065.111e-06InformativeDirect
Biological Process (BP)glycosyl compound biosynthetic process0.00097760.0004904InformativeDirect
Biological Process (BP)purine nucleoside metabolic process0.93640.8705InformativeInherited
Biological Process (BP)ribonucleoside metabolic process0.0025270.001215InformativeInherited
Biological Process (BP)alpha-amino acid biosynthetic process0.58141InformativeInherited
Biological Process (BP)internal protein amino acid acetylation1.805e-098.588e-07Highly InformativeDirect
Biological Process (BP)arginine metabolic process1.404e-089.824e-08Highly InformativeDirect
Biological Process (BP)locomotory behavior1.415e-071.031e-05Highly InformativeDirect
Biological Process (BP)aerobic respiration1.591e-117.958e-12Highly InformativeDirect
Biological Process (BP)glutamine family amino acid biosynthetic process5.698e-050.0007759Highly InformativeDirect
Biological Process (BP)nucleoside monophosphate metabolic process1.771e-056.679e-07Highly InformativeDirect
Biological Process (BP)dicarboxylic acid metabolic process5.107e-084.125e-07Highly InformativeDirect
Molecular Function (MF)structural molecule activity0.00030830.0009361Moderately InformativeDirect
Molecular Function (MF)lyase activity00Moderately InformativeDirect
Molecular Function (MF)carbon-oxygen lyase activity11InformativeInherited
Cellular Component (CC)cytoplasmic part0.0002461.518e-06Least InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle0.01280.551Least InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) nitrogen compound metabolic process 1.821e-05 Least Informative Direct
Biological Process (BP) single-organism metabolic process 4.008e-15 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 0.9504 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.9117 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.9868 Least Informative Inherited
Biological Process (BP) response to stimulus 0.9092 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.02805 Least Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0 Moderately Informative Direct
Biological Process (BP) organonitrogen compound biosynthetic process 1.334e-05 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0.8447 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.8573 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.0483 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.05739 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.009319 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.04967 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.3342 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.2594 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.6774 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.07313 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.07929 Moderately Informative Inherited
Biological Process (BP) oxidation-reduction process 0.4146 Moderately Informative Inherited
Biological Process (BP) purine nucleotide metabolic process 7.523e-07 Informative Direct
Biological Process (BP) glutamine family amino acid metabolic process 4.997e-09 Informative Direct
Biological Process (BP) nucleotide biosynthetic process 4.063e-09 Informative Direct
Biological Process (BP) energy derivation by oxidation of organic compounds 1.243e-07 Informative Direct
Biological Process (BP) ribose phosphate metabolic process 5.67e-05 Informative Direct
Biological Process (BP) single-organism behavior 0.0007371 Informative Direct
Biological Process (BP) purine-containing compound biosynthetic process 5.111e-06 Informative Direct
Biological Process (BP) glycosyl compound biosynthetic process 0.0004904 Informative Direct
Biological Process (BP) purine nucleoside metabolic process 0.8705 Informative Inherited
Biological Process (BP) ribonucleoside metabolic process 0.001215 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 0.57 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 0.07344 Informative Inherited
Biological Process (BP) alpha-amino acid biosynthetic process 1 Informative Inherited
Biological Process (BP) internal protein amino acid acetylation 8.588e-07 Highly Informative Direct
Biological Process (BP) arginine metabolic process 9.824e-08 Highly Informative Direct
Biological Process (BP) locomotory behavior 1.031e-05 Highly Informative Direct
Biological Process (BP) aerobic respiration 7.958e-12 Highly Informative Direct
Biological Process (BP) glutamine family amino acid biosynthetic process 0.0007759 Highly Informative Direct
Biological Process (BP) nucleoside monophosphate metabolic process 6.679e-07 Highly Informative Direct
Biological Process (BP) dicarboxylic acid metabolic process 4.125e-07 Highly Informative Direct
Molecular Function (MF) structural molecule activity 0.0009361 Moderately Informative Direct
Molecular Function (MF) lyase activity 0 Moderately Informative Direct
Molecular Function (MF) carbon-oxygen lyase activity 1 Informative Inherited
Cellular Component (CC) cytoplasmic part 1.518e-06 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.551 Least Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Hydro-lyases0Moderately InformativeDirect
Enzyme Commission (EC)Carbon-nitrogen lyases0InformativeDirect
Enzyme Commission (EC)Lyases acting on amides, amidines, etc1.741e-12Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the central nervous system0Least InformativeDirect
Phenotypic Abnormality (PA)Growth abnormality0Moderately InformativeDirect
Phenotypic Abnormality (PA)Morphological abnormality of the central nervous system0Moderately InformativeDirect
Phenotypic Abnormality (PA)Cognitive impairment0Moderately InformativeDirect
Phenotypic Abnormality (PA)Intellectual disability0InformativeDirect
Phenotypic Abnormality (PA)Seizures0InformativeDirect
Phenotypic Abnormality (PA)Global developmental delay0InformativeDirect

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Carbon-oxygen lyases1Moderately InformativeInherited
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)Intramolecular transferases (mutases)1InformativeInherited
Enzyme Commission (EC)Lyases acting on amides, amidines, etc0Highly InformativeDirect
Enzyme Commission (EC)Ammonia-lyases0.2932Highly InformativeInherited
Enzyme Commission (EC)Intramolecular lyases1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAmino-acid biosynthesis0Moderately InformativeDirect
Biological processTricarboxylic acid cycle0InformativeDirect
Biological processPurine biosynthesis1.149e-05InformativeDirect
Biological processArginine biosynthesis0Highly InformativeDirect
Biological processHistidine metabolism0Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Post-translational modificationLyase0Moderately InformativeDirect
Post-translational modificationEye lens protein1.444e-06Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)amino-acid metabolism0Least InformativeDirect
UniPathway (UP)carbohydrate metabolism1Least InformativeInherited
UniPathway (UP)aromatic compound metabolism1Least InformativeInherited
UniPathway (UP)proteinogenic amino-acid biosynthesis0Moderately InformativeDirect
UniPathway (UP)amino-acid degradation0Moderately InformativeDirect
UniPathway (UP)aromatic compound biosynthesis5.148e-05Moderately InformativeDirect
UniPathway (UP)nitrogen metabolism1Moderately InformativeInherited
UniPathway (UP)nucleotide metabolism1Moderately InformativeInherited
UniPathway (UP)purine metabolism1Moderately InformativeInherited
UniPathway (UP)L-arginine biosynthesis0InformativeDirect
UniPathway (UP)tricarboxylic acid cycle0InformativeDirect
UniPathway (UP)phenylpropanoid biosynthesis0InformativeDirect
UniPathway (UP)histidine metabolism0.002796InformativeInherited
UniPathway (UP)L-histidine degradation0Highly InformativeDirect
UniPathway (UP)urea cycle4.1e-06Highly InformativeDirect
UniPathway (UP)AMP biosynthesis4.836e-05Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR008948 SSF48557 Protein matches
Abstract

The enzyme L-aspartate ammonia-lyase (aspartase) catalyses the reversible deamination of the amino acid L-aspartic acid, using a carbanion mechanism to produce fumaric acid and ammonium ion. Aspartases from different organisms show high sequence homology, and this homology extends to functionally related enzymes such as the class II fumarases, the argininosuccinate and adenylosuccinate lyases. The high-resolution structure of aspartase reveals a monomer that is composed of three domains oriented in an elongated S-shape [PubMed9230045]. The central domain, comprised of five-helices, provides the subunit contacts in the functionally active tetramer. The active sites are located in clefts between the subunits and structural and mutagenic studies have identified several of the active site functional groups. A separate regulatory site has been identified. The substrate, aspartic acid, can also play the role of an activator, binding at this site along with a required divalent metal ion.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 18 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a L-aspartase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 18 hidden Markov models representing the L-aspartase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]