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GroEL equatorial domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   GroEL equatorial domain-like [ 48591]
Superfamily:   GroEL equatorial domain-like [ 48592] (2)
Families:   GroEL chaperone, ATPase domain [ 48593]
  Group II chaperonin (CCT, TRIC), ATPase domain [ 48596]


Superfamily statistics
Genomes (3,199) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 11,456 71,532 29
Proteins 11,024 69,029 29


Functional annotation
General category Processes_IC
Detailed category Protein modification

Document:
Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)genetic disease0.004132Moderately InformativeInherited
Disease Ontology (DO)autosomal recessive disease0.002348InformativeInherited
Disease Ontology (DO)Bardet-Biedl syndrome0.00000006705Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the skeletal system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the musculature0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of limbs0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.0808Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.1014Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.1077Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.1614Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the head0.1763Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal muscle morphology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the urinary system0.02908Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ear0.04663Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal reproductive system morphology0.07603Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye morphology0.0773Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.08091Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limb bone morphology0.08384Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the nose0.1043Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.1418Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin adnexa morphology0.1823Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper limb0.3273Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ovary0.0007468InformativeDirect
Phenotypic Abnormality (PA)Abnormal retinal morphology0.002361InformativeInherited
Phenotypic Abnormality (PA)Abnormal eyebrow morphology0.0054InformativeInherited
Phenotypic Abnormality (PA)Abnormal renal physiology0.009044InformativeInherited
Phenotypic Abnormality (PA)Abnormal renal morphology0.02833InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the outer ear0.03876InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle size0.115InformativeInherited
Phenotypic Abnormality (PA)Abnormality of finger0.3876InformativeInherited
Phenotypic Abnormality (PA)Rod-cone dystrophy0.000001955Highly InformativeDirect
Phenotypic Abnormality (PA)Hypoplasia of the ovary0.000007447Highly InformativeDirect
Phenotypic Abnormality (PA)Hepatic fibrosis0.00004336Highly InformativeDirect
Phenotypic Abnormality (PA)Postaxial polydactyly0.00004336Highly InformativeDirect
Phenotypic Abnormality (PA)Generalized hirsutism0.00004782Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal electroretinogram0.0003412Highly InformativeDirect
Phenotypic Abnormality (PA)Skeletal muscle atrophy0.0003609Highly InformativeDirect
Phenotypic Abnormality (PA)Low-set, posteriorly rotated ears0.0005817Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the nasal bridge0.02662Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of retinal pigmentation0.07952Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)growth/size/body region phenotype0.06823Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.2597Least InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.007282Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.01966Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal body composition0.2471Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal postnatal growth/weight/body size0.5347Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal circulating leptin level0.00006709InformativeDirect
Mammalian Phenotype (MP)increased body weight0.0002439InformativeDirect
Mammalian Phenotype (MP)obese0.000003716Highly InformativeDirect
Mammalian Phenotype (MP)retinal degeneration0.000004794Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0Least InformativeDirect
Worm Phenotype (WP)cell development variant0Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval growth variant0Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.00000656Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.000009888Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.00001006Least InformativeDirect
Worm Phenotype (WP)reproductive system morphology variant0Moderately InformativeDirect
Worm Phenotype (WP)gametogenesis variant0Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0Moderately InformativeDirect
Worm Phenotype (WP)level of transgene expression variant0Moderately InformativeDirect
Worm Phenotype (WP)cell component morphology variant0Moderately InformativeDirect
Worm Phenotype (WP)early embryonic lethal0.000000000168Moderately InformativeDirect
Worm Phenotype (WP)protein protein interaction variant0.000000002287Moderately InformativeDirect
Worm Phenotype (WP)germ cell morphology variant0.00000006798Moderately InformativeDirect
Worm Phenotype (WP)apoptosis variant0.0000009244Moderately InformativeDirect
Worm Phenotype (WP)life span variant0.000062Moderately InformativeDirect
Worm Phenotype (WP)metabolic pathway variant0.0006552Moderately InformativeDirect
Worm Phenotype (WP)feeding behavior variant0.0006837Moderately InformativeDirect
Worm Phenotype (WP)cell division variant0.001385Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.1045Moderately InformativeInherited
Worm Phenotype (WP)reproductive system development variant0.1128Moderately InformativeInherited
Worm Phenotype (WP)transgene expression increased0InformativeDirect
Worm Phenotype (WP)pleiotropic defects severe early emb0.00000000000116InformativeDirect
Worm Phenotype (WP)pachytene progression during oogenesis variant0.00000000000188InformativeDirect
Worm Phenotype (WP)germ cell compartment expansion variant0.00000000003306InformativeDirect
Worm Phenotype (WP)oocyte morphology variant0.0000000008016InformativeDirect
Worm Phenotype (WP)avoids bacterial lawn0.000000006974InformativeDirect
Worm Phenotype (WP)pigmentation variant0.0000004339InformativeDirect
Worm Phenotype (WP)protruding vulva0.0000005738InformativeDirect
Worm Phenotype (WP)cell stress response variant0.0000008484InformativeDirect
Worm Phenotype (WP)endocytic transport defect0.000002169InformativeDirect
Worm Phenotype (WP)accumulated germline cell corpses0.000005297InformativeDirect
Worm Phenotype (WP)gonad development variant0.00003251InformativeDirect
Worm Phenotype (WP)sick0.0002224InformativeDirect
Worm Phenotype (WP)oocyte physiology variant0.0004069InformativeDirect
Worm Phenotype (WP)cell component localization variant0.004479InformativeInherited
Worm Phenotype (WP)endosome morphology variant0.008018InformativeInherited
Worm Phenotype (WP)organelle organization biogenesis variant0.03725InformativeInherited
Worm Phenotype (WP)mitosis variant0.09035InformativeInherited
Worm Phenotype (WP)rachis morphology variant0.2174InformativeInherited
Worm Phenotype (WP)organism pathogen response variant0.2573InformativeInherited
Worm Phenotype (WP)meiotic chromosome organization variant0.7423InformativeInherited
Worm Phenotype (WP)oocytes small0.000000000000002665Highly InformativeDirect
Worm Phenotype (WP)unfolded protein response variant0.0000000000396Highly InformativeDirect
Worm Phenotype (WP)recycling endosome localization variant0.000000006578Highly InformativeDirect
Worm Phenotype (WP)germ cell compartment anucleate0.00000003586Highly InformativeDirect
Worm Phenotype (WP)male somatic gonad development variant0.0000003401Highly InformativeDirect
Worm Phenotype (WP)gonad arm morphology variant0.0000006943Highly InformativeDirect
Worm Phenotype (WP)no oocytes0.000003509Highly InformativeDirect
Worm Phenotype (WP)chromosome condensation variant0.00003292Highly InformativeDirect
Worm Phenotype (WP)no induction of antimicrobial peptide expression after infection0.00006924Highly InformativeDirect
Worm Phenotype (WP)cell membrane organization biogenesis variant0.0004213Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)adult0.04228Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.3051Least InformativeInherited
Fly Anatomy (FA)adult heart0.0000000004334InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0.7501Least InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.01263Moderately InformativeInherited
Zebrafish Anatomy (ZA)electrically active cell0.09755Moderately InformativeInherited
Zebrafish Anatomy (ZA)muscle0.04532InformativeInherited
Zebrafish Anatomy (ZA)myotome0.000007947Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.03173Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.1139Least InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.0001111Moderately InformativeDirect
Xenopus ANatomical entity (XAN)embryonic structure0.02199Moderately InformativeInherited
Xenopus ANatomical entity (XAN)skeletal muscle0.000001276InformativeDirect
Xenopus ANatomical entity (XAN)immune system0.0001458InformativeDirect
Xenopus ANatomical entity (XAN)dermal system0.0001839InformativeDirect
Xenopus ANatomical entity (XAN)endocrine system0.0002516InformativeDirect
Xenopus ANatomical entity (XAN)anatomical entity in vitro0.0006549InformativeDirect
Xenopus ANatomical entity (XAN)endomesoderm0.0006932InformativeDirect
Xenopus ANatomical entity (XAN)tail0.0007053InformativeDirect
Xenopus ANatomical entity (XAN)surface structure0.001847InformativeInherited
Xenopus ANatomical entity (XAN)mesoderm0.01402InformativeInherited
Xenopus ANatomical entity (XAN)anterior dorsal lateral plate region0.000005113Highly InformativeDirect
Xenopus DEvelopment stage (XDE)unspecified stage0.0009284Moderately InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)seed development stage0.000000004758InformativeDirect
Plant structure DEvelopment stage (PDE)0 seed germination stage0.0002307InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0Moderately InformativeDirect

Document: EC annotation of SCOP domains

InterPro annotation
Cross references IPR008950 SSF48592 Protein matches
Abstract

Partially folded polypeptide chains, either newly made by ribosomes or emerging from mature proteins unfolded by stress, run the risk of aggregating with one another to the detriment of the organism. Folding of newly synthesised polypeptides in the crowded cellular environment requires the assistance of molecular chaperone proteins, such as the large bacterial chaperonins GroEL and GroES.

GroEL and GroES prevent aggregation by encapsulating individual chains within the so-called ┐Anfinsen cage┐ provided by the GroEL┐GroES complex, where they can fold in isolation from one another [PubMed12654267]. GroEL consists of two heptameric rings of identical ATPase subunits stacked back to back, containing a cage in each ring. Each subunit consists of three domains. The equatorial domain contains the nucleotide binding site and is connected by a flexible intermediate domain with the apical domain. The latter presents several hydrophobic amino-acid side chains at the top of the ring, orientated towards the cavity of the cage. These side chains are involved in binding either a partially folded polypeptide chain or a single molecule of GroES.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 7 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a GroEL equatorial domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 7 hidden Markov models representing the GroEL equatorial domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]