SUPERFAMILY 1.75 HMM library and genome assignments server

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Immunoglobulin superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Immunoglobulin-like beta-sandwich [ 48725] (28)
Superfamily:   Immunoglobulin [ 48726] (4)
Families:   V set domains (antibody variable domain-like) [ 48727] (32)
  C1 set domains (antibody constant domain-like) [ 48942] (23)
  C2 set domains [ 49142] (8)
  I set domains [ 49159] (38)


Superfamily statistics
Genomes (309) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 172,246 427,705 2,226
Proteins 61,415 162,384 1,346


Functional annotation
General category Processes_EC
Detailed category Cell adhesion

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism cellular process00Least InformativeDirect
Biological Process (BP)response to stimulus00Least InformativeDirect
Biological Process (BP)biological regulation00Least InformativeDirect
Biological Process (BP)multicellular organismal process0.1590Least InformativeInherited
Biological Process (BP)organonitrogen compound metabolic process01Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.76390Least InformativeInherited
Biological Process (BP)macromolecule metabolic process01Least InformativeInherited
Biological Process (BP)primary metabolic process01Least InformativeInherited
Biological Process (BP)immune system process00Moderately InformativeDirect
Biological Process (BP)defense response0.00000007380Moderately InformativeDirect
Biological Process (BP)cell communication00Moderately InformativeDirect
Biological Process (BP)anatomical structure morphogenesis0.00038860Moderately InformativeDirect
Biological Process (BP)single organism signaling00Moderately InformativeDirect
Biological Process (BP)single-organism transport0.0000000000000031440Moderately InformativeDirect
Biological Process (BP)animal organ development0.0006590.000004444Moderately InformativeDirect
Biological Process (BP)regulation of response to stimulus00Moderately InformativeDirect
Biological Process (BP)regulation of protein metabolic process00Moderately InformativeDirect
Biological Process (BP)multi-organism process0.00028160Moderately InformativeDirect
Biological Process (BP)regulation of gene expression0.000002321Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process10Moderately InformativeInherited
Biological Process (BP)response to external stimulus10Moderately InformativeInherited
Biological Process (BP)response to biotic stimulus0.42590.00000006401Moderately InformativeInherited
Biological Process (BP)cellular localization11Moderately InformativeInherited
Biological Process (BP)regulation of molecular function11Moderately InformativeInherited
Biological Process (BP)regulation of localization10.004991Moderately InformativeInherited
Biological Process (BP)regulation of developmental process10Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process11Moderately InformativeInherited
Biological Process (BP)regulation of signaling10.4756Moderately InformativeInherited
Biological Process (BP)regulation of cell communication10.6245Moderately InformativeInherited
Biological Process (BP)macromolecule localization11Moderately InformativeInherited
Biological Process (BP)cellular component assembly0.21091Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization10Moderately InformativeInherited
Biological Process (BP)cell differentiation0.87550.0000000009638Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process11Moderately InformativeInherited
Biological Process (BP)regulation of biological quality11Moderately InformativeInherited
Biological Process (BP)organelle organization0.30041Moderately InformativeInherited
Biological Process (BP)immune effector process00.00003039InformativeDirect
Biological Process (BP)positive regulation of immune system process00InformativeDirect
Biological Process (BP)movement of cell or subcellular component00InformativeDirect
Biological Process (BP)immune response00InformativeDirect
Biological Process (BP)cell surface receptor signaling pathway00InformativeDirect
Biological Process (BP)vesicle-mediated transport00InformativeDirect
Biological Process (BP)regulation of proteolysis00.000003484InformativeDirect
Biological Process (BP)regulation of defense response0.000000000078820InformativeDirect
Biological Process (BP)regulation of protein modification process0.00047430InformativeDirect
Biological Process (BP)regulation of response to external stimulus00.000001768InformativeDirect
Biological Process (BP)locomotion00InformativeDirect
Biological Process (BP)regulation of phosphorylation0.00023210.0000003103InformativeDirect
Biological Process (BP)cell development0.00084370InformativeDirect
Biological Process (BP)anatomical structure formation involved in morphogenesis0.0000013530.000000000531InformativeDirect
Biological Process (BP)generation of neurons0.000000025660.00000008928InformativeDirect
Biological Process (BP)regulation of immune response00InformativeDirect
Biological Process (BP)negative regulation of multicellular organismal process0.00000007480.000000002245InformativeDirect
Biological Process (BP)regulation of transferase activity0.0000010760.000000003519InformativeDirect
Biological Process (BP)localization of cell00InformativeDirect
Biological Process (BP)regulation of nervous system development0.000000000045880InformativeDirect
Biological Process (BP)animal organ morphogenesis0.0000087091InformativeInherited
Biological Process (BP)negative regulation of cellular component organization0.00000000040850.2857InformativeInherited
Biological Process (BP)regulation of cell differentiation0.28770InformativeInherited
Biological Process (BP)regulation of transmembrane transport0.0000000092760.2969InformativeInherited
Biological Process (BP)regulation of cellular localization0.00045641InformativeInherited
Biological Process (BP)regulation of cellular component movement0.080950.00000000001582InformativeInherited
Biological Process (BP)negative regulation of response to stimulus10.36InformativeInherited
Biological Process (BP)negative regulation of cell communication0.000009340.1135InformativeInherited
Biological Process (BP)negative regulation of signaling0.000009340.08226InformativeInherited
Biological Process (BP)regulation of locomotion0.078610.0000000000007387InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis0.004420InformativeInherited
Biological Process (BP)regulation of ion transport0.00000086420.2465InformativeInherited
Biological Process (BP)positive regulation of transport10.2872InformativeInherited
Biological Process (BP)cation homeostasis0.000000061880.7976InformativeInherited
Biological Process (BP)cellular chemical homeostasis0.053840.9057InformativeInherited
Biological Process (BP)inorganic ion homeostasis0.000000065970.6107InformativeInherited
Biological Process (BP)circulatory system development0.00054810.3116InformativeInherited
Biological Process (BP)angiogenesis0.0000000023790.0000000000752Highly InformativeDirect
Biological Process (BP)regulation of acute inflammatory response00Highly InformativeDirect
Biological Process (BP)immune response-activating signal transduction0.000021370.000001325Highly InformativeDirect
Biological Process (BP)regulation of humoral immune response00.00000004857Highly InformativeDirect
Biological Process (BP)phagocytosis00Highly InformativeDirect
Biological Process (BP)regulation of cell morphogenesis involved in differentiation0.000010170Highly InformativeDirect
Biological Process (BP)biological adhesion0.000000000010280Highly InformativeDirect
Biological Process (BP)negative regulation of locomotion0.000000000003740.00000000002482Highly InformativeDirect
Biological Process (BP)neuron development0.0000000025890Highly InformativeDirect
Biological Process (BP)regulation of T cell activation00.000000000000007296Highly InformativeDirect
Biological Process (BP)leukocyte migration00Highly InformativeDirect
Biological Process (BP)negative regulation of cellular component movement0.0000000000026570.0000000000269Highly InformativeDirect
Biological Process (BP)regulation of protein processing00Highly InformativeDirect
Biological Process (BP)sensory organ morphogenesis0.0000014230.00001389Highly InformativeDirect
Biological Process (BP)regulation of neuron projection development0.0071290Highly InformativeInherited
Biological Process (BP)negative regulation of nervous system development0.000000000016770.1352Highly InformativeInherited
Biological Process (BP)regulation of cellular response to stress0.74251Highly InformativeInherited
Biological Process (BP)regulation of cation transmembrane transport0.0000000000052010.03158Highly InformativeInherited
Biological Process (BP)regulation of ion homeostasis0.055290.6383Highly InformativeInherited
Biological Process (BP)cellular calcium ion homeostasis0.0000000012390.2271Highly InformativeInherited
Biological Process (BP)positive regulation of ion transport0.000000040010.03078Highly InformativeInherited
Biological Process (BP)positive regulation of transmembrane transport0.0000000006410.03827Highly InformativeInherited
Biological Process (BP)regulation of calcium ion transport0.014350.3366Highly InformativeInherited
Biological Process (BP)negative regulation of immune system process0.22370Highly InformativeInherited
Biological Process (BP)camera-type eye development0.00000000084340.05592Highly InformativeInherited
Biological Process (BP)protein localization to membrane0.013020.004297Highly InformativeInherited
Biological Process (BP)positive regulation of lymphocyte activation00.0661Highly InformativeInherited
Biological Process (BP)negative regulation of cell development0.0000000022970.1035Highly InformativeInherited
Biological Process (BP)positive regulation of homeostatic process0.000026750.002137Highly InformativeInherited
Biological Process (BP)positive regulation of immune effector process10.3555Highly InformativeInherited
Biological Process (BP)positive regulation of adaptive immune response based on somatic recombination of immune receptors b0.00015020.1005Highly InformativeInherited
Biological Process (BP)regulation of leukocyte mediated immunity10.1246Highly InformativeInherited
Biological Process (BP)positive regulation of cell adhesion0.0013270Highly InformativeInherited
Molecular Function (MF)binding0.00000029710Least InformativeDirect
Molecular Function (MF)hydrolase activity01Least InformativeInherited
Molecular Function (MF)transferase activity11Least InformativeInherited
Molecular Function (MF)carbohydrate derivative binding0.13761Moderately InformativeInherited
Molecular Function (MF)anion binding0.073081Moderately InformativeInherited
Molecular Function (MF)structural molecule activity0.20690Moderately InformativeInherited
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups0.2610.00000000001933Moderately InformativeInherited
Molecular Function (MF)receptor binding0.000022520.0000000005598InformativeDirect
Molecular Function (MF)amide binding0.0000018830InformativeDirect
Molecular Function (MF)peptidase activity, acting on L-amino acid peptides00.000000003964InformativeDirect
Molecular Function (MF)phospholipid binding0.0000000044090.3979InformativeInherited
Molecular Function (MF)kinase activity0.10330InformativeInherited
Molecular Function (MF)phosphotransferase activity, alcohol group as acceptor0.024210InformativeInherited
Molecular Function (MF)serine hydrolase activity00Highly InformativeDirect
Molecular Function (MF)peptide binding0.0000000031970.0000898Highly InformativeDirect
Molecular Function (MF)cell adhesion molecule binding0.00021080Highly InformativeDirect
Molecular Function (MF)glycolipid binding00.000000000001142Highly InformativeDirect
Molecular Function (MF)protein kinase activity0.0022080Highly InformativeInherited
Cellular Component (CC)membrane00Least InformativeDirect
Cellular Component (CC)plasma membrane00Moderately InformativeDirect
Cellular Component (CC)vesicle0.0000000000008410Moderately InformativeDirect
Cellular Component (CC)extracellular region part00Moderately InformativeDirect
Cellular Component (CC)whole membrane10.0000009057Moderately InformativeInherited
Cellular Component (CC)cell projection0.061550Moderately InformativeInherited
Cellular Component (CC)cell surface00InformativeDirect
Cellular Component (CC)neuron projection0.000051990InformativeDirect
Cellular Component (CC)extracellular organelle00InformativeDirect
Cellular Component (CC)side of membrane00InformativeDirect
Cellular Component (CC)membrane region0.14220.3312InformativeInherited
Cellular Component (CC)extracellular space00.7291InformativeInherited
Cellular Component (CC)plasma membrane region10.98InformativeInherited
Cellular Component (CC)plasma membrane bounded cell projection part0.000063981InformativeInherited
Cellular Component (CC)external side of plasma membrane00Highly InformativeDirect
Cellular Component (CC)growth cone0.000000000000058430.00001961Highly InformativeDirect
Cellular Component (CC)main axon0.000006590.00004926Highly InformativeDirect
Cellular Component (CC)extracellular exosome0.00082640.0000004372Highly InformativeDirect
Cellular Component (CC)blood microparticle00.00000001245Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details) <
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.0001303 Moderately Informative Direct
Biological Process (BP) defense response 0 Moderately Informative Direct
Biological Process (BP) cell communication 0 Moderately Informative Direct
Biological Process (BP) response to external stimulus 0 Moderately Informative Direct
Biological Process (BP) response to biotic stimulus 0.00000006401 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0 Moderately Informative Direct
Biological Process (BP) cell differentiation 0.0000000009638 Moderately Informative Direct
Biological Process (BP) single organism signaling 0 Moderately Informative Direct
Biological Process (BP) single-organism transport 0 Moderately Informative Direct
Biological Process (BP) animal organ development 0.000004444 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0 Moderately Informative Direct
Biological Process (BP) multi-organism process 0 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.004991 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.4756 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) nitrogen compound transport 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.173 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.4393 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.6245 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) protein complex biogenesis 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) cell activation 0 Informative Direct
Biological Process (BP) regulation of cytokine production 0.00006074 Informative Direct
Biological Process (BP) immune effector process 0.00003039 Informative Direct
Biological Process (BP) positive regulation of immune system process 0 Informative Direct
Biological Process (BP) system process 0.0000003571 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0 Informative Direct
Biological Process (BP) immune response 0 Informative Direct
Biological Process (BP) cell surface receptor signaling pathway 0 Informative Direct
Biological Process (BP) central nervous system development 0.0000000000009364 Informative Direct
Biological Process (BP) response to wounding 0 Informative Direct
Biological Process (BP) response to bacterium 0.00000000001149 Informative Direct
Biological Process (BP) vesicle-mediated transport 0 Informative Direct
Biological Process (BP) phosphorylation 0 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0 Informative Direct
Biological Process (BP) actin cytoskeleton organization 0.000000000000005563 Informative Direct
Biological Process (BP) regulation of proteolysis 0.000003484 Informative Direct
Biological Process (BP) regulation of defense response 0 Informative Direct
Biological Process (BP) regulation of protein modification process 0 Informative Direct
Biological Process (BP) regulation of response to external stimulus 0.000001768 Informative Direct
Biological Process (BP) positive regulation of cellular protein metabolic process 0 Informative Direct
Biological Process (BP) secretion by cell 0.0004906 Informative Direct
Biological Process (BP) cellular component morphogenesis 0 Informative Direct
Biological Process (BP) growth 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) regulation of locomotion 0.0000000000007387 Informative Direct
Biological Process (BP) regulation of cell proliferation 0.00000000002131 Informative Direct
Biological Process (BP) regulation of phosphorylation 0.0000003103 Informative Direct
Biological Process (BP) positive regulation of catalytic activity 0.0000005619 Informative Direct
Biological Process (BP) regulation of cell differentiation 0 Informative Direct
Biological Process (BP) positive regulation of phosphate metabolic process 0.0000000007533 Informative Direct
Biological Process (BP) cell development 0 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.000000000531 Informative Direct
Biological Process (BP) generation of neurons 0.00000008928 Informative Direct