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Immunoglobulin superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Immunoglobulin-like beta-sandwich [ 48725] (28)
Superfamily:   Immunoglobulin [ 48726] (4)
Families:   V set domains (antibody variable domain-like) [ 48727] (32)
  C1 set domains (antibody constant domain-like) [ 48942] (23)
  C2 set domains [ 49142] (8)
  I set domains [ 49159] (38)


Superfamily statistics
Genomes (309) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 172,246 530,434 2,226
Proteins 61,415 198,234 1,346


Functional annotation
General category Processes_EC
Detailed category Cell adhesion

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0.0001702Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0.0000000000000076Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.2423Moderately InformativeInherited
Enzyme Commission (EC)Receptor protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0InformativeDirect
Enzyme Commission (EC)Peroxidases0.00002546InformativeDirect
Enzyme Commission (EC)Peroxidase0.00000000001632Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.002802Least InformativeInherited
Disease Ontology (DO)nervous system disease0.4639Least InformativeInherited
Disease Ontology (DO)disease by infectious agent0.00002555Moderately InformativeDirect
Disease Ontology (DO)urinary system disease0.04885Moderately InformativeInherited
Disease Ontology (DO)neurodegenerative disease0.06151Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.09692Moderately InformativeInherited
Disease Ontology (DO)connective tissue disease0.1232Moderately InformativeInherited
Disease Ontology (DO)genetic disease0.9713Moderately InformativeInherited
Disease Ontology (DO)multiple sclerosis0.0000000000001097InformativeDirect
Disease Ontology (DO)allergic rhinitis0.0003094InformativeDirect
Disease Ontology (DO)alopecia0.000428InformativeDirect
Disease Ontology (DO)autosomal recessive disease0.1601InformativeInherited
Disease Ontology (DO)female reproductive organ cancer0.26InformativeInherited
Disease Ontology (DO)connective tissue cancer0.7839InformativeInherited
Disease Ontology (DO)Graves' disease0.0000004893Highly InformativeDirect
Disease Ontology (DO)sickle cell anemia0.00002574Highly InformativeDirect
Disease Ontology (DO)acute kidney failure0.0001293Highly InformativeDirect
Disease Ontology (DO)lupus erythematosus0.01751Highly InformativeInherited
Disease Ontology (DO)osteosarcoma0.6774Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the integument0.2235Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.2648Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.5678Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the head0.7056Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.7456Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.7512Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.989Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology1Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal respiratory system morphology0.1944Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.2072Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiovascular system physiology0.3379Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of immune system physiology0.437Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.5436Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.6227Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limb bone morphology0.6374Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.6828Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin morphology0.8366Moderately InformativeInherited
Phenotypic Abnormality (PA)Behavioral abnormality0.9864Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal oral cavity morphology1Moderately InformativeInherited
Phenotypic Abnormality (PA)Inflammatory abnormality of the eye0.000005231InformativeDirect
Phenotypic Abnormality (PA)Unusual CNS infection0.001578InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin physiology0.03231InformativeInherited
Phenotypic Abnormality (PA)Internal hemorrhage0.2815InformativeInherited
Phenotypic Abnormality (PA)Localized skin lesion0.3375InformativeInherited
Phenotypic Abnormality (PA)Abnormal lung morphology0.3946InformativeInherited
Phenotypic Abnormality (PA)Abnormality of toe0.4854InformativeInherited
Phenotypic Abnormality (PA)Abnormal cellular immune system morphology0.6217InformativeInherited
Phenotypic Abnormality (PA)Abnormal lower limb bone morphology0.6314InformativeInherited
Phenotypic Abnormality (PA)Aplasia/hypoplasia of the extremities0.6539InformativeInherited
Phenotypic Abnormality (PA)Diabetes insipidus0.00007597Highly InformativeDirect
Phenotypic Abnormality (PA)Skin plaque0.0004552Highly InformativeDirect
Phenotypic Abnormality (PA)Meningitis0.0004666Highly InformativeDirect
Phenotypic Abnormality (PA)Inflammatory abnormality of the skin0.1508Highly InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia of toe0.1793Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the phalanges of the toes0.2602Highly InformativeInherited
Phenotypic Abnormality (PA)Short digit0.7419Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.00000000195Least InformativeDirect
Mammalian Phenotype (MP)hematopoietic system phenotype0.00000003983Least InformativeDirect
Mammalian Phenotype (MP)nervous system phenotype0.2462Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis1Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging1Least InformativeInherited
Mammalian Phenotype (MP)abnormal induced morbidity/mortality0.0661Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.1728Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0.9931Moderately InformativeInherited
Mammalian Phenotype (MP)reproductive system phenotype1Moderately InformativeInherited
Mammalian Phenotype (MP)autoimmune response0.000000002904InformativeDirect
Mammalian Phenotype (MP)abnormal innervation0.0006166InformativeDirect
Mammalian Phenotype (MP)abnormal female reproductive gland morphology0.9377InformativeInherited
Mammalian Phenotype (MP)abnormal internal female genitalia morphology0.9858InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to infection induced morbidity/mortality0.0002494Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell morphology variant0.0001022Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.0009359Least InformativeDirect
Worm Phenotype (WP)cell development variant0.04806Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.05902Least InformativeInherited
Worm Phenotype (WP)blast cell physiology variant0.6011Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.6019Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.9264Least InformativeInherited
Worm Phenotype (WP)organism behavior variant1Least InformativeInherited
Worm Phenotype (WP)body morphology variant0.0000002252Moderately InformativeDirect
Worm Phenotype (WP)nervous system morphology variant0.00005761Moderately InformativeDirect
Worm Phenotype (WP)movement variant0.0004426Moderately InformativeDirect
Worm Phenotype (WP)reproductive system development variant0.0006763Moderately InformativeDirect
Worm Phenotype (WP)body region morphology variant0.000984Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant0.000984Moderately InformativeDirect
Worm Phenotype (WP)developmental morphology variant0.0009946Moderately InformativeDirect
Worm Phenotype (WP)adult body morphology variant0.001005Moderately InformativeInherited
Worm Phenotype (WP)drug response variant0.006521Moderately InformativeInherited
Worm Phenotype (WP)metabolic pathway variant0.03522Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.1452Moderately InformativeInherited
Worm Phenotype (WP)germ cell morphology variant1Moderately InformativeInherited
Worm Phenotype (WP)anchor cell invasion variant0InformativeDirect
Worm Phenotype (WP)axon outgrowth variant0.0000000001521InformativeDirect
Worm Phenotype (WP)body posture variant0.000008729InformativeDirect
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.00002681InformativeDirect
Worm Phenotype (WP)aldicarb response variant0.00005938InformativeDirect
Worm Phenotype (WP)locomotion reduced0.0001926InformativeDirect
Worm Phenotype (WP)neuron morphology variant0.0002688InformativeDirect
Worm Phenotype (WP)tail morphology variant0.0005033InformativeDirect
Worm Phenotype (WP)mitochondria morphology variant0.0006483InformativeDirect
Worm Phenotype (WP)protein metabolism variant0.01886InformativeInherited
Worm Phenotype (WP)neuron migration variant0.6313InformativeInherited
Worm Phenotype (WP)epithelial system development variant0.7363InformativeInherited
Worm Phenotype (WP)muscle arm development defective0.0000000002817Highly InformativeDirect
Worm Phenotype (WP)synapse morphology variant0.000001981Highly InformativeDirect
Worm Phenotype (WP)protein degradation variant0.00003877Highly InformativeDirect
Worm Phenotype (WP)growth rate variant0.00009966Highly InformativeDirect
Worm Phenotype (WP)exploded through vulva0.0003618Highly InformativeDirect
Worm Phenotype (WP)neuropil development variant0.001839Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)cell migration defective0.0001259Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)nervous system0.003008Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.003484Least InformativeInherited
Fly Anatomy (FA)larva0.07246Least InformativeInherited
Fly Anatomy (FA)somatic cell0.1225Least InformativeInherited
Fly Anatomy (FA)adult0.1636Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.1934Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.0000001214Moderately InformativeDirect
Fly Anatomy (FA)central nervous system0.001415Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.007916Moderately InformativeInherited
Fly Anatomy (FA)ganglion0.008566Moderately InformativeInherited
Fly Anatomy (FA)sensory system0.02307Moderately InformativeInherited
Fly Anatomy (FA)late embryo0.03644Moderately InformativeInherited
Fly Anatomy (FA)neuron0.0759Moderately InformativeInherited
Fly Anatomy (FA)adult nervous system0.1583Moderately InformativeInherited
Fly Anatomy (FA)somatic precursor cell0.3301Moderately InformativeInherited
Fly Anatomy (FA)head0.6946Moderately InformativeInherited
Fly Anatomy (FA)larval abdomen0.0000002156InformativeDirect
Fly Anatomy (FA)nerve0.0004475InformativeDirect
Fly Anatomy (FA)embryonic/larval peripheral nervous system0.0006229InformativeDirect
Fly Anatomy (FA)primordium0.005472InformativeInherited
Fly Anatomy (FA)larval segment0.007414InformativeInherited
Fly Anatomy (FA)brain0.01173InformativeInherited
Fly Anatomy (FA)syncytium0.01707InformativeInherited
Fly Anatomy (FA)ventral nerve cord0.03025InformativeInherited
Fly Anatomy (FA)abdominal segment0.04135InformativeInherited
Fly Anatomy (FA)muscle system0.04994InformativeInherited
Fly Anatomy (FA)adult central nervous system0.09753InformativeInherited
Fly Anatomy (FA)dorsal closure embryo0.1027InformativeInherited
Fly Anatomy (FA)chemosensory system0.1185InformativeInherited
Fly Anatomy (FA)tract0.6005InformativeInherited
Fly Anatomy (FA)synaptic neuropil domain0.6459InformativeInherited
Fly Anatomy (FA)embryonic heart cardioblast0.0000002873Highly InformativeDirect
Fly Anatomy (FA)leg taste bristle chemosensory neuron0.00004268Highly InformativeDirect
Fly Anatomy (FA)longitudinal muscle0.0001145Highly InformativeDirect
Fly Anatomy (FA)LNv neuron0.000119Highly InformativeDirect
Fly Anatomy (FA)connective0.0001328Highly InformativeDirect
Fly Anatomy (FA)commissure0.0003111Highly InformativeDirect
Fly Anatomy (FA)heart primordium0.0004233Highly InformativeDirect
Fly Anatomy (FA)abdominal segmental nerve0.0008659Highly InformativeDirect
Fly Anatomy (FA)larval VNC neuropil glial cell0.01819Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)compound organ0.05782Least InformativeInherited
Zebrafish Anatomy (ZA)multi-tissue structure0.06106Least InformativeInherited
Zebrafish Anatomy (ZA)organism subdivision0.7166Least InformativeInherited
Zebrafish Anatomy (ZA)nervous system1Least InformativeInherited
Zebrafish Anatomy (ZA)central nervous system0.7488Moderately InformativeInherited
Zebrafish Anatomy (ZA)sensory system1Moderately InformativeInherited
Zebrafish Anatomy (ZA)forebrain0.444InformativeInherited
Zebrafish Anatomy (ZA)surface structure0.8989InformativeInherited
Zebrafish Anatomy (ZA)medial longitudinal fasciculus0.00008593Highly InformativeDirect
Zebrafish Anatomy (ZA)scale0.0009879Highly InformativeDirect
Zebrafish Anatomy (ZA)glomerular layer0.001112Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus DEvelopment stage (XDE)post-embryonic stage1Least InformativeInherited
Xenopus DEvelopment stage (XDE)embryonic stage0.000001093Moderately InformativeDirect
Xenopus DEvelopment stage (XDE)adult frog stage0.0002223Highly InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.07718Moderately InformativeInherited
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0InformativeDirect
Enzyme Commission (EC)Acting on a peroxide as acceptor0.00002965InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 450 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Immunoglobulin domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 450 hidden Markov models representing the Immunoglobulin superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]