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Immunoglobulin superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Immunoglobulin-like beta-sandwich [ 48725] (28)
Superfamily:   Immunoglobulin [ 48726] (4)
Families:   V set domains (antibody variable domain-like) [ 48727] (32)
  C1 set domains (antibody constant domain-like) [ 48942] (23)
  C2 set domains [ 49142] (8)
  I set domains [ 49159] (38)


Superfamily statistics
Genomes (309) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 172,246 530,434 2,226
Proteins 61,415 198,234 1,346


Functional annotation
General category Processes_EC
Detailed category Cell adhesion

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0.0001702Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0.0000000000000076Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.2423Moderately InformativeInherited
Enzyme Commission (EC)Receptor protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0InformativeDirect
Enzyme Commission (EC)Peroxidases0.00002546InformativeDirect
Enzyme Commission (EC)Peroxidase0.00000000001632Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.00237Least InformativeInherited
Disease Ontology (DO)nervous system disease0.4433Least InformativeInherited
Disease Ontology (DO)disease by infectious agent0.00002113Moderately InformativeDirect
Disease Ontology (DO)urinary system disease0.04495Moderately InformativeInherited
Disease Ontology (DO)neurodegenerative disease0.06178Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.09661Moderately InformativeInherited
Disease Ontology (DO)connective tissue disease0.1188Moderately InformativeInherited
Disease Ontology (DO)genetic disease0.9683Moderately InformativeInherited
Disease Ontology (DO)multiple sclerosis0.00000000000009281InformativeDirect
Disease Ontology (DO)allergic rhinitis0.0002947InformativeDirect
Disease Ontology (DO)alopecia0.000412InformativeDirect
Disease Ontology (DO)autosomal recessive disease0.1563InformativeInherited
Disease Ontology (DO)female reproductive organ cancer0.2535InformativeInherited
Disease Ontology (DO)connective tissue cancer0.7846InformativeInherited
Disease Ontology (DO)Graves' disease0.0000004566Highly InformativeDirect
Disease Ontology (DO)sickle cell anemia0.00002541Highly InformativeDirect
Disease Ontology (DO)acute kidney failure0.000128Highly InformativeDirect
Disease Ontology (DO)lupus erythematosus0.0174Highly InformativeInherited
Disease Ontology (DO)osteosarcoma0.678Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the integument0.1381Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.5445Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the head0.6579Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.6873Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.733Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.9867Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology1Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.1886Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.518Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal oral cavity morphology0.557Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.5599Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of immune system physiology0.6112Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.7008Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limb bone morphology0.7548Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the skull0.8981Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal leukocyte morphology0.0003212InformativeDirect
Phenotypic Abnormality (PA)Abnormality of toe0.5058InformativeInherited
Phenotypic Abnormality (PA)Aplasia/hypoplasia of the extremities0.5833InformativeInherited
Phenotypic Abnormality (PA)Functional respiratory abnormality0.7979InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the calvaria0.9055InformativeInherited
Phenotypic Abnormality (PA)Behavioral abnormality0.9589InformativeInherited
Phenotypic Abnormality (PA)Increased inflammatory response1InformativeInherited
Phenotypic Abnormality (PA)Cough0.000252Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skin physiology0.04407Highly InformativeInherited
Phenotypic Abnormality (PA)Short toe0.08277Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the phalanges of the toes0.2142Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of calvarial morphology0.8533Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.000000001295Least InformativeDirect
Mammalian Phenotype (MP)hematopoietic system phenotype0.00000002778Least InformativeDirect
Mammalian Phenotype (MP)nervous system phenotype0.2601Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis1Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging1Least InformativeInherited
Mammalian Phenotype (MP)abnormal induced morbidity/mortality0.0682Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.1434Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.5637Moderately InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to infection0.5946Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0.9953Moderately InformativeInherited
Mammalian Phenotype (MP)reproductive system phenotype1Moderately InformativeInherited
Mammalian Phenotype (MP)autoimmune response0.000000003254InformativeDirect
Mammalian Phenotype (MP)abnormal innervation0.0006154InformativeDirect
Mammalian Phenotype (MP)abnormal mature B cell morphology0.5417InformativeInherited
Mammalian Phenotype (MP)abnormal female reproductive gland morphology0.9395InformativeInherited
Mammalian Phenotype (MP)abnormal internal female genitalia morphology0.9865InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to infection induced morbidity/mortality0.0002489Highly InformativeDirect
Mammalian Phenotype (MP)abnormal B-1 B cell number0.0004437Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organ system morphology variant0.000696Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0.004199Least InformativeInherited
Worm Phenotype (WP)cell development variant0.03251Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.07582Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.6185Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.9024Least InformativeInherited
Worm Phenotype (WP)organism behavior variant1Least InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.00000022Moderately InformativeDirect
Worm Phenotype (WP)nervous system morphology variant0.0001657Moderately InformativeDirect
Worm Phenotype (WP)reproductive system development variant0.000612Moderately InformativeDirect
Worm Phenotype (WP)movement variant0.0009922Moderately InformativeDirect
Worm Phenotype (WP)metabolic pathway variant0.006844Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.01068Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.1481Moderately InformativeInherited
Worm Phenotype (WP)cell component morphology variant0.9895Moderately InformativeInherited
Worm Phenotype (WP)germ cell morphology variant1Moderately InformativeInherited
Worm Phenotype (WP)mitochondria morphology variant0.000004927InformativeDirect
Worm Phenotype (WP)body posture variant0.000006202InformativeDirect
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.00002571InformativeDirect
Worm Phenotype (WP)protein degradation variant0.00002866InformativeDirect
Worm Phenotype (WP)aldicarb response variant0.00004779InformativeDirect
Worm Phenotype (WP)locomotion reduced0.0001496InformativeDirect
Worm Phenotype (WP)neuronal outgrowth variant0.01201InformativeInherited
Worm Phenotype (WP)neuron migration variant0.634InformativeInherited
Worm Phenotype (WP)epithelial system development variant0.7403InformativeInherited
Worm Phenotype (WP)anchor cell invasion variant0Highly InformativeDirect
Worm Phenotype (WP)muscle arm development defective0.0000000002377Highly InformativeDirect
Worm Phenotype (WP)growth rate variant0.00008671Highly InformativeDirect
Worm Phenotype (WP)exploded through vulva0.0003446Highly InformativeDirect
Worm Phenotype (WP)neuropil development variant0.00196Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system subdivision0.0001042Least InformativeDirect
Fly Anatomy (FA)anatomical group0.001211Least InformativeInherited
Fly Anatomy (FA)nervous system0.002979Least InformativeInherited
Fly Anatomy (FA)embryo0.01447Least InformativeInherited
Fly Anatomy (FA)larva0.03411Least InformativeInherited
Fly Anatomy (FA)somatic cell0.05294Least InformativeInherited
Fly Anatomy (FA)adult0.08159Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.0000003464Moderately InformativeDirect
Fly Anatomy (FA)central nervous system0.005312Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.02371Moderately InformativeInherited
Fly Anatomy (FA)late embryo0.02774Moderately InformativeInherited
Fly Anatomy (FA)neuron0.06227Moderately InformativeInherited
Fly Anatomy (FA)cell cluster organ0.09138Moderately InformativeInherited
Fly Anatomy (FA)sense organ0.1347Moderately InformativeInherited
Fly Anatomy (FA)somatic precursor cell0.5956Moderately InformativeInherited
Fly Anatomy (FA)adult segment0.6438Moderately InformativeInherited
Fly Anatomy (FA)adult thorax0.9069Moderately InformativeInherited
Fly Anatomy (FA)appendage0.9578Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.9854Moderately InformativeInherited
Fly Anatomy (FA)thoracic segment1Moderately InformativeInherited
Fly Anatomy (FA)tagmatic subdivision of integument1Moderately InformativeInherited
Fly Anatomy (FA)larval abdomen0.0000002868InformativeDirect
Fly Anatomy (FA)nerve0.0003153InformativeDirect
Fly Anatomy (FA)syncytium0.01691InformativeInherited
Fly Anatomy (FA)abdominal segment0.0461InformativeInherited
Fly Anatomy (FA)muscle system0.05107InformativeInherited
Fly Anatomy (FA)chaeta0.08439InformativeInherited
Fly Anatomy (FA)chemosensory system0.08662InformativeInherited
Fly Anatomy (FA)leg0.7021InformativeInherited
Fly Anatomy (FA)tract0.7631InformativeInherited
Fly Anatomy (FA)prothoracic leg taste bristle chemosensory neuron0.00003827Highly InformativeDirect
Fly Anatomy (FA)longitudinal muscle0.00008399Highly InformativeDirect
Fly Anatomy (FA)connective0.000109Highly InformativeDirect
Fly Anatomy (FA)abdominal nerve0.0001579Highly InformativeDirect
Fly Anatomy (FA)commissure0.0002619Highly InformativeDirect
Fly Anatomy (FA)neuropil glial sheath0.0003457Highly InformativeDirect
Fly Anatomy (FA)inter-ommatidial precursor cell0.0009789Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)multi-tissue structure0.04587Least InformativeInherited
Zebrafish Anatomy (ZA)nervous system1Least InformativeInherited
Zebrafish Anatomy (ZA)central nervous system0.7074Moderately InformativeInherited
Zebrafish Anatomy (ZA)medial longitudinal fasciculus0.00008851Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus DEvelopment stage (XDE)embryonic stage0.0000004464Moderately InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.1494Moderately InformativeInherited
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0InformativeDirect
Enzyme Commission (EC)Acting on a peroxide as acceptor0.00002807InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 336 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Immunoglobulin domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 336 hidden Markov models representing the Immunoglobulin superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]