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Immunoglobulin superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Immunoglobulin-like beta-sandwich [ 48725] (28)
Superfamily:   Immunoglobulin [ 48726] (4)
Families:   V set domains (antibody variable domain-like) [ 48727] (32)
  C1 set domains (antibody constant domain-like) [ 48942] (23)
  C2 set domains [ 49142] (8)
  I set domains [ 49159] (38)


Superfamily statistics
Genomes (309) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 172,246 530,434 2,226
Proteins 61,415 198,234 1,346


Functional annotation
General category Processes_EC
Detailed category Cell adhesion

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0.0001702Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0.0000000000000076Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.2423Moderately InformativeInherited
Enzyme Commission (EC)Receptor protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0InformativeDirect
Enzyme Commission (EC)Peroxidases0.00002546InformativeDirect
Enzyme Commission (EC)Peroxidase0.00000000001632Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.00275Least InformativeInherited
Disease Ontology (DO)nervous system disease0.4668Least InformativeInherited
Disease Ontology (DO)disease by infectious agent0.00002551Moderately InformativeDirect
Disease Ontology (DO)urinary system disease0.04881Moderately InformativeInherited
Disease Ontology (DO)neurodegenerative disease0.06199Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.0969Moderately InformativeInherited
Disease Ontology (DO)connective tissue disease0.1189Moderately InformativeInherited
Disease Ontology (DO)genetic disease0.9714Moderately InformativeInherited
Disease Ontology (DO)multiple sclerosis0.0000000000001097InformativeDirect
Disease Ontology (DO)allergic rhinitis0.0003092InformativeDirect
Disease Ontology (DO)alopecia0.0004277InformativeDirect
Disease Ontology (DO)autosomal recessive disease0.1601InformativeInherited
Disease Ontology (DO)female reproductive organ cancer0.26InformativeInherited
Disease Ontology (DO)connective tissue cancer0.7839InformativeInherited
Disease Ontology (DO)Graves' disease0.0000004901Highly InformativeDirect
Disease Ontology (DO)sickle cell anemia0.00002571Highly InformativeDirect
Disease Ontology (DO)acute kidney failure0.0001291Highly InformativeDirect
Disease Ontology (DO)lupus erythematosus0.0175Highly InformativeInherited
Disease Ontology (DO)osteosarcoma0.6776Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the integument0.1655Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.1772Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the skeletal system0.5891Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.6456Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.7413Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the head0.746Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.9804Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology1Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the respiratory system0.1215Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.1462Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiovascular system physiology0.2482Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.5137Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of immune system physiology0.5155Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.561Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.578Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limb bone morphology0.6339Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin morphology0.837Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal oral cavity morphology1Moderately InformativeInherited
Phenotypic Abnormality (PA)Behavioral abnormality1Moderately InformativeInherited
Phenotypic Abnormality (PA)Unusual CNS infection0.001109InformativeInherited
Phenotypic Abnormality (PA)Abnormal immune system morphology0.02033InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin physiology0.03917InformativeInherited
Phenotypic Abnormality (PA)Internal hemorrhage0.1846InformativeInherited
Phenotypic Abnormality (PA)Abnormal lung morphology0.3493InformativeInherited
Phenotypic Abnormality (PA)Abnormality of toe0.5388InformativeInherited
Phenotypic Abnormality (PA)Aplasia/hypoplasia of the extremities0.626InformativeInherited
Phenotypic Abnormality (PA)Abnormal lower limb bone morphology0.6363InformativeInherited
Phenotypic Abnormality (PA)Functional respiratory abnormality0.7744InformativeInherited
Phenotypic Abnormality (PA)Increased inflammatory response1InformativeInherited
Phenotypic Abnormality (PA)Diabetes insipidus0.00007269Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal leukocyte morphology0.0001472Highly InformativeDirect
Phenotypic Abnormality (PA)Cough0.0001909Highly InformativeDirect
Phenotypic Abnormality (PA)Meningitis0.0003369Highly InformativeDirect
Phenotypic Abnormality (PA)Inflammatory abnormality of the skin0.1577Highly InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia of toe0.1697Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the phalanges of the toes0.2272Highly InformativeInherited
Phenotypic Abnormality (PA)Short digit0.7163Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.000000001264Least InformativeDirect
Mammalian Phenotype (MP)hematopoietic system phenotype0.00000002654Least InformativeDirect
Mammalian Phenotype (MP)nervous system phenotype0.2604Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis1Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging1Least InformativeInherited
Mammalian Phenotype (MP)abnormal induced morbidity/mortality0.06781Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.144Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.5637Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0.995Moderately InformativeInherited
Mammalian Phenotype (MP)reproductive system phenotype1Moderately InformativeInherited
Mammalian Phenotype (MP)autoimmune response0.000000003199InformativeDirect
Mammalian Phenotype (MP)abnormal innervation0.0006104InformativeDirect
Mammalian Phenotype (MP)abnormal mature B cell morphology0.5417InformativeInherited
Mammalian Phenotype (MP)abnormal female reproductive gland morphology0.9393InformativeInherited
Mammalian Phenotype (MP)abnormal internal female genitalia morphology0.9865InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to infection induced morbidity/mortality0.0002492Highly InformativeDirect
Mammalian Phenotype (MP)abnormal B-1 B cell number0.0004419Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organ system morphology variant0.0009026Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0.002349Least InformativeInherited
Worm Phenotype (WP)cell development variant0.03587Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.05684Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.6398Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.9136Least InformativeInherited
Worm Phenotype (WP)organism behavior variant1Least InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.0000002556Moderately InformativeDirect
Worm Phenotype (WP)nervous system morphology variant0.0002797Moderately InformativeDirect
Worm Phenotype (WP)movement variant0.0004299Moderately InformativeDirect
Worm Phenotype (WP)reproductive system development variant0.0006745Moderately InformativeDirect
Worm Phenotype (WP)metabolic pathway variant0.009434Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.02383Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.09427Moderately InformativeInherited
Worm Phenotype (WP)germ cell morphology variant1Moderately InformativeInherited
Worm Phenotype (WP)cell component morphology variant1Moderately InformativeInherited
Worm Phenotype (WP)anchor cell invasion variant0InformativeDirect
Worm Phenotype (WP)axon outgrowth variant0.0000000001439InformativeDirect
Worm Phenotype (WP)neurite morphology variant0.00000003482InformativeDirect
Worm Phenotype (WP)mitochondria morphology variant0.000005682InformativeDirect
Worm Phenotype (WP)body posture variant0.00001033InformativeDirect
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.00002567InformativeDirect
Worm Phenotype (WP)protein degradation variant0.00003733InformativeDirect
Worm Phenotype (WP)aldicarb response variant0.00005892InformativeDirect
Worm Phenotype (WP)locomotion reduced0.0001848InformativeDirect
Worm Phenotype (WP)neuron migration variant0.6357InformativeInherited
Worm Phenotype (WP)epithelial system development variant0.7425InformativeInherited
Worm Phenotype (WP)muscle arm development defective0.0000000002691Highly InformativeDirect
Worm Phenotype (WP)growth rate variant0.00009593Highly InformativeDirect
Worm Phenotype (WP)exploded through vulva0.0003485Highly InformativeDirect
Worm Phenotype (WP)neuropil development variant0.001808Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)cell migration defective0.0001272Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)nervous system0.002666Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.003237Least InformativeInherited
Fly Anatomy (FA)larva0.0701Least InformativeInherited
Fly Anatomy (FA)somatic cell0.1167Least InformativeInherited
Fly Anatomy (FA)adult0.1622Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.1901Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.00000009629Moderately InformativeDirect
Fly Anatomy (FA)central nervous system0.001229Moderately InformativeInherited
Fly Anatomy (FA)ganglion0.00735Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.007577Moderately InformativeInherited
Fly Anatomy (FA)sensory system0.02184Moderately InformativeInherited
Fly Anatomy (FA)late embryo0.03683Moderately InformativeInherited
Fly Anatomy (FA)neuron0.07163Moderately InformativeInherited
Fly Anatomy (FA)adult nervous system0.1574Moderately InformativeInherited
Fly Anatomy (FA)somatic precursor cell0.3263Moderately InformativeInherited
Fly Anatomy (FA)head0.6892Moderately InformativeInherited
Fly Anatomy (FA)larval abdomen0.0000001967InformativeDirect
Fly Anatomy (FA)nerve0.0004077InformativeDirect
Fly Anatomy (FA)embryonic/larval peripheral nervous system0.000646InformativeDirect
Fly Anatomy (FA)primordium0.005493InformativeInherited
Fly Anatomy (FA)larval segment0.007285InformativeInherited
Fly Anatomy (FA)brain0.01023InformativeInherited
Fly Anatomy (FA)syncytium0.01708InformativeInherited
Fly Anatomy (FA)ventral nerve cord0.03319InformativeInherited
Fly Anatomy (FA)abdominal segment0.04213InformativeInherited
Fly Anatomy (FA)muscle system0.04924InformativeInherited
Fly Anatomy (FA)adult central nervous system0.09219InformativeInherited
Fly Anatomy (FA)dorsal closure embryo0.1048InformativeInherited
Fly Anatomy (FA)chemosensory system0.1074InformativeInherited
Fly Anatomy (FA)tract0.6172InformativeInherited
Fly Anatomy (FA)synaptic neuropil domain0.6413InformativeInherited
Fly Anatomy (FA)embryonic heart cardioblast0.0000002899Highly InformativeDirect
Fly Anatomy (FA)leg taste bristle chemosensory neuron0.00004285Highly InformativeDirect
Fly Anatomy (FA)longitudinal muscle0.0001152Highly InformativeDirect
Fly Anatomy (FA)LNv neuron0.0001267Highly InformativeDirect
Fly Anatomy (FA)connective0.0001339Highly InformativeDirect
Fly Anatomy (FA)commissure0.0003113Highly InformativeDirect
Fly Anatomy (FA)heart primordium0.0004284Highly InformativeDirect
Fly Anatomy (FA)abdominal segmental nerve0.000868Highly InformativeDirect
Fly Anatomy (FA)larval VNC neuropil glial cell0.01847Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)compound organ0.08328Least InformativeInherited
Zebrafish Anatomy (ZA)multi-tissue structure0.08581Least InformativeInherited
Zebrafish Anatomy (ZA)organism subdivision0.75Least InformativeInherited
Zebrafish Anatomy (ZA)nervous system1Least InformativeInherited
Zebrafish Anatomy (ZA)central nervous system0.7454Moderately InformativeInherited
Zebrafish Anatomy (ZA)sensory system1Moderately InformativeInherited
Zebrafish Anatomy (ZA)forebrain0.4164InformativeInherited
Zebrafish Anatomy (ZA)surface structure0.8947InformativeInherited
Zebrafish Anatomy (ZA)medial longitudinal fasciculus0.00008556Highly InformativeDirect
Zebrafish Anatomy (ZA)scale0.0009824Highly InformativeDirect
Zebrafish Anatomy (ZA)glomerular layer0.001069Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)anatomical system1Least InformativeInherited
Xenopus ANatomical entity (XAN)head1Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue1Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ1Least InformativeInherited
Xenopus ANatomical entity (XAN)sensory system0.09144Moderately InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.1248Moderately InformativeInherited
Xenopus ANatomical entity (XAN)eye0.1122InformativeInherited
Xenopus ANatomical entity (XAN)retinal neural layer0.1392Highly InformativeInherited
Xenopus DEvelopment stage (XDE)post-embryonic stage1Least InformativeInherited
Xenopus DEvelopment stage (XDE)embryonic stage0.0000006632Moderately InformativeDirect
Xenopus DEvelopment stage (XDE)adult frog stage0.0002146Highly InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.07632Moderately InformativeInherited
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0InformativeDirect
Enzyme Commission (EC)Acting on a peroxide as acceptor0.00002964InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 450 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Immunoglobulin domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 450 hidden Markov models representing the Immunoglobulin superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]