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Immunoglobulin superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Immunoglobulin-like beta-sandwich [ 48725] (28)
Superfamily:   Immunoglobulin [ 48726] (4)
Families:   V set domains (antibody variable domain-like) [ 48727] (32)
  C1 set domains (antibody constant domain-like) [ 48942] (23)
  C2 set domains [ 49142] (8)
  I set domains [ 49159] (38)


Superfamily statistics
Genomes (309) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 172,246 530,434 2,226
Proteins 61,415 198,234 1,346


Functional annotation
General category Processes_EC
Detailed category Cell adhesion

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0.0001702Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0.0000000000000076Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.2423Moderately InformativeInherited
Enzyme Commission (EC)Receptor protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0InformativeDirect
Enzyme Commission (EC)Peroxidases0.00002546InformativeDirect
Enzyme Commission (EC)Peroxidase0.00000000001632Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.002366Least InformativeInherited
Disease Ontology (DO)nervous system disease0.4447Least InformativeInherited
Disease Ontology (DO)disease by infectious agent0.0000214Moderately InformativeDirect
Disease Ontology (DO)urinary system disease0.04514Moderately InformativeInherited
Disease Ontology (DO)neurodegenerative disease0.06186Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.09666Moderately InformativeInherited
Disease Ontology (DO)connective tissue disease0.1182Moderately InformativeInherited
Disease Ontology (DO)genetic disease0.9686Moderately InformativeInherited
Disease Ontology (DO)multiple sclerosis0.00000000000009281InformativeDirect
Disease Ontology (DO)allergic rhinitis0.0002956InformativeDirect
Disease Ontology (DO)alopecia0.0004135InformativeDirect
Disease Ontology (DO)autosomal recessive disease0.1567InformativeInherited
Disease Ontology (DO)female reproductive organ cancer0.2534InformativeInherited
Disease Ontology (DO)connective tissue cancer0.7846InformativeInherited
Disease Ontology (DO)Graves' disease0.0000004588Highly InformativeDirect
Disease Ontology (DO)sickle cell anemia0.00002541Highly InformativeDirect
Disease Ontology (DO)acute kidney failure0.000128Highly InformativeDirect
Disease Ontology (DO)lupus erythematosus0.01741Highly InformativeInherited
Disease Ontology (DO)osteosarcoma0.678Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the skeletal system0.5233Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.6126Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the head0.6612Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.678Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.9702Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology1Least InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.001777Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the respiratory system0.1185Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.1281Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.4318Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of immune system physiology0.4944Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.5568Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal oral cavity morphology0.5603Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.6117Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limb bone0.6769Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal appendicular skeleton morphology0.7324Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin morphology0.8483Moderately InformativeInherited
Phenotypic Abnormality (PA)Behavioral abnormality0.9664Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of toe0.4275InformativeInherited
Phenotypic Abnormality (PA)Aplasia/hypoplasia of the extremities0.4747InformativeInherited
Phenotypic Abnormality (PA)Abnormal inflammatory response0.4753InformativeInherited
Phenotypic Abnormality (PA)Abnormality of lower limb bone0.5337InformativeInherited
Phenotypic Abnormality (PA)Abnormal bone structure0.59InformativeInherited
Phenotypic Abnormality (PA)Functional respiratory abnormality0.8127InformativeInherited
Phenotypic Abnormality (PA)Abnormal leukocyte morphology0.000102Highly InformativeDirect
Phenotypic Abnormality (PA)Cough0.0004336Highly InformativeDirect
Phenotypic Abnormality (PA)Short toe0.03544Highly InformativeInherited
Phenotypic Abnormality (PA)Inflammatory abnormality of the skin0.1936Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the phalanges of the toes0.2417Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.000000001295Least InformativeDirect
Mammalian Phenotype (MP)hematopoietic system phenotype0.00000002778Least InformativeDirect
Mammalian Phenotype (MP)nervous system phenotype0.2601Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis1Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging1Least InformativeInherited
Mammalian Phenotype (MP)abnormal induced morbidity/mortality0.0682Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.1434Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.5637Moderately InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to infection0.5946Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0.9953Moderately InformativeInherited
Mammalian Phenotype (MP)reproductive system phenotype1Moderately InformativeInherited
Mammalian Phenotype (MP)autoimmune response0.000000003254InformativeDirect
Mammalian Phenotype (MP)abnormal innervation0.0006154InformativeDirect
Mammalian Phenotype (MP)abnormal mature B cell morphology0.5417InformativeInherited
Mammalian Phenotype (MP)abnormal female reproductive gland morphology0.9395InformativeInherited
Mammalian Phenotype (MP)abnormal internal female genitalia morphology0.9865InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to infection induced morbidity/mortality0.0002489Highly InformativeDirect
Mammalian Phenotype (MP)abnormal B-1 B cell number0.0004437Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organ system morphology variant0.0009186Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0.005005Least InformativeInherited
Worm Phenotype (WP)cell development variant0.0398Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.08702Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.6467Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.9224Least InformativeInherited
Worm Phenotype (WP)organism behavior variant1Least InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.0000003005Moderately InformativeDirect
Worm Phenotype (WP)nervous system morphology variant0.0001727Moderately InformativeDirect
Worm Phenotype (WP)reproductive system development variant0.0006237Moderately InformativeDirect
Worm Phenotype (WP)movement variant0.001203Moderately InformativeInherited
Worm Phenotype (WP)metabolic pathway variant0.007766Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.01019Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.1622Moderately InformativeInherited
Worm Phenotype (WP)cell component morphology variant0.9928Moderately InformativeInherited
Worm Phenotype (WP)germ cell morphology variant1Moderately InformativeInherited
Worm Phenotype (WP)axon outgrowth variant0.00000000008318InformativeDirect
Worm Phenotype (WP)neurite morphology variant0.00000002228InformativeDirect
Worm Phenotype (WP)mitochondria morphology variant0.000006029InformativeDirect
Worm Phenotype (WP)body posture variant0.000006237InformativeDirect
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.00003107InformativeDirect
Worm Phenotype (WP)protein degradation variant0.00003253InformativeDirect
Worm Phenotype (WP)aldicarb response variant0.00005135InformativeDirect
Worm Phenotype (WP)growth rate variant0.00009789InformativeDirect
Worm Phenotype (WP)locomotion reduced0.000174InformativeDirect
Worm Phenotype (WP)neuron migration variant0.6288InformativeInherited
Worm Phenotype (WP)epithelial system development variant0.7419InformativeInherited
Worm Phenotype (WP)anchor cell invasion variant0Highly InformativeDirect
Worm Phenotype (WP)muscle arm development defective0.0000000002747Highly InformativeDirect
Worm Phenotype (WP)exploded through vulva0.0003879Highly InformativeDirect
Worm Phenotype (WP)neuropil development variant0.001805Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)cell migration defective0.0003103InformativeDirect
Fly Phenotype (FP)cell adhesion defective0.0009341Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system subdivision0.0003995Least InformativeDirect
Fly Anatomy (FA)anatomical group0.001456Least InformativeInherited
Fly Anatomy (FA)nervous system0.003292Least InformativeInherited
Fly Anatomy (FA)larva0.03632Least InformativeInherited
Fly Anatomy (FA)somatic cell0.05693Least InformativeInherited
Fly Anatomy (FA)adult0.08375Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.1166Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.00000009381Moderately InformativeDirect
Fly Anatomy (FA)central nervous system0.001394Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.007047Moderately InformativeInherited
Fly Anatomy (FA)late embryo0.0296Moderately InformativeInherited
Fly Anatomy (FA)developing embryonic structure0.05226Moderately InformativeInherited
Fly Anatomy (FA)neuron0.06335Moderately InformativeInherited
Fly Anatomy (FA)cell cluster organ0.09736Moderately InformativeInherited
Fly Anatomy (FA)adult nervous system0.1222Moderately InformativeInherited
Fly Anatomy (FA)sense organ0.1405Moderately InformativeInherited
Fly Anatomy (FA)somatic precursor cell0.3598Moderately InformativeInherited
Fly Anatomy (FA)adult segment0.5264Moderately InformativeInherited
Fly Anatomy (FA)head0.6848Moderately InformativeInherited
Fly Anatomy (FA)adult thorax0.9022Moderately InformativeInherited
Fly Anatomy (FA)appendage0.9543Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.9834Moderately InformativeInherited
Fly Anatomy (FA)thoracic segment1Moderately InformativeInherited
Fly Anatomy (FA)tagmatic subdivision of integument1Moderately InformativeInherited
Fly Anatomy (FA)larval abdomen0.00000027InformativeDirect
Fly Anatomy (FA)nerve0.0003152InformativeDirect
Fly Anatomy (FA)adult brain0.0003828InformativeDirect
Fly Anatomy (FA)embryonic/larval peripheral nervous system0.0004015InformativeDirect
Fly Anatomy (FA)synaptic neuropil0.0004462InformativeDirect
Fly Anatomy (FA)primordium0.00468InformativeInherited
Fly Anatomy (FA)larval segment0.007857InformativeInherited
Fly Anatomy (FA)syncytium0.01651InformativeInherited
Fly Anatomy (FA)abdominal segment0.04631InformativeInherited
Fly Anatomy (FA)muscle system0.05259InformativeInherited
Fly Anatomy (FA)chaeta0.08744InformativeInherited
Fly Anatomy (FA)chemosensory system0.09158InformativeInherited
Fly Anatomy (FA)dorsal closure embryo0.1242InformativeInherited
Fly Anatomy (FA)tract0.6863InformativeInherited
Fly Anatomy (FA)leg0.7018InformativeInherited
Fly Anatomy (FA)embryonic heart cardioblast0.000002876Highly InformativeDirect
Fly Anatomy (FA)heart primordium0.00003727Highly InformativeDirect
Fly Anatomy (FA)prothoracic leg taste bristle chemosensory neuron0.00003863Highly InformativeDirect
Fly Anatomy (FA)longitudinal muscle0.00008432Highly InformativeDirect
Fly Anatomy (FA)connective0.0001092Highly InformativeDirect
Fly Anatomy (FA)LNv neuron0.0001282Highly InformativeDirect
Fly Anatomy (FA)abdominal nerve0.0001556Highly InformativeDirect
Fly Anatomy (FA)commissure0.000263Highly InformativeDirect
Fly Anatomy (FA)neuropil glial sheath0.0003408Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)multi-tissue structure0.0671Least InformativeInherited
Zebrafish Anatomy (ZA)nervous system1Least InformativeInherited
Zebrafish Anatomy (ZA)central nervous system0.7418Moderately InformativeInherited
Zebrafish Anatomy (ZA)medial longitudinal fasciculus0.00008679Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus DEvelopment stage (XDE)embryonic stage0.000000481Moderately InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.0769Moderately InformativeInherited
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0InformativeDirect
Enzyme Commission (EC)Acting on a peroxide as acceptor0.00003017InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 450 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Immunoglobulin domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 450 hidden Markov models representing the Immunoglobulin superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]