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Immunoglobulin superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Immunoglobulin-like beta-sandwich [ 48725] (28)
Superfamily:   Immunoglobulin [ 48726] (4)
Families:   V set domains (antibody variable domain-like) [ 48727] (32)
  C1 set domains (antibody constant domain-like) [ 48942] (23)
  C2 set domains [ 49142] (8)
  I set domains [ 49159] (38)


Superfamily statistics
Genomes (309) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 172,246 530,434 2,226
Proteins 61,415 198,234 1,346


Functional annotation
General category Processes_EC
Detailed category Cell adhesion

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0.0001702Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0.0000000000000076Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.2423Moderately InformativeInherited
Enzyme Commission (EC)Receptor protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0InformativeDirect
Enzyme Commission (EC)Peroxidases0.00002546InformativeDirect
Enzyme Commission (EC)Peroxidase0.00000000001632Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.002802Least InformativeInherited
Disease Ontology (DO)nervous system disease0.4639Least InformativeInherited
Disease Ontology (DO)disease by infectious agent0.00002555Moderately InformativeDirect
Disease Ontology (DO)urinary system disease0.04885Moderately InformativeInherited
Disease Ontology (DO)neurodegenerative disease0.06151Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.09692Moderately InformativeInherited
Disease Ontology (DO)connective tissue disease0.1232Moderately InformativeInherited
Disease Ontology (DO)genetic disease0.9713Moderately InformativeInherited
Disease Ontology (DO)multiple sclerosis0.0000000000001097InformativeDirect
Disease Ontology (DO)allergic rhinitis0.0003094InformativeDirect
Disease Ontology (DO)alopecia0.000428InformativeDirect
Disease Ontology (DO)autosomal recessive disease0.1601InformativeInherited
Disease Ontology (DO)female reproductive organ cancer0.26InformativeInherited
Disease Ontology (DO)connective tissue cancer0.7839InformativeInherited
Disease Ontology (DO)Graves' disease0.0000004893Highly InformativeDirect
Disease Ontology (DO)sickle cell anemia0.00002574Highly InformativeDirect
Disease Ontology (DO)acute kidney failure0.0001293Highly InformativeDirect
Disease Ontology (DO)lupus erythematosus0.01751Highly InformativeInherited
Disease Ontology (DO)osteosarcoma0.6774Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.1887Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.1952Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.4459Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.7685Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.7831Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the head0.8639Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.884Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.9997Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system1Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0.04477Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.0804Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digestive system physiology0.3481Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of immune system physiology0.4575Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.6514Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system morphology0.6755Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.6937Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.7044Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limb bone morphology0.7722Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin morphology0.9611Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal oral cavity morphology1Moderately InformativeInherited
Phenotypic Abnormality (PA)Inflammatory abnormality of the eye0.00001079InformativeDirect
Phenotypic Abnormality (PA)Unusual CNS infection0.002671InformativeInherited
Phenotypic Abnormality (PA)Functional abnormality of the gastrointestinal tract0.08723InformativeInherited
Phenotypic Abnormality (PA)Localized skin lesion0.3341InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower urinary tract0.412InformativeInherited
Phenotypic Abnormality (PA)Abnormality of toe0.5772InformativeInherited
Phenotypic Abnormality (PA)Abnormal cellular immune system morphology0.6157InformativeInherited
Phenotypic Abnormality (PA)Aplasia/hypoplasia of the extremities0.6424InformativeInherited
Phenotypic Abnormality (PA)Abnormal lower limb bone morphology0.6523InformativeInherited
Phenotypic Abnormality (PA)Diabetes insipidus0.000126Highly InformativeDirect
Phenotypic Abnormality (PA)Pericarditis0.0004491Highly InformativeDirect
Phenotypic Abnormality (PA)Skin plaque0.0007142Highly InformativeDirect
Phenotypic Abnormality (PA)Meningitis0.0007877Highly InformativeDirect
Phenotypic Abnormality (PA)Aplasia/Hypoplasia of toe0.1996Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the phalanges of the toes0.3568Highly InformativeInherited
Phenotypic Abnormality (PA)Functional abnormality of the bladder0.5032Highly InformativeInherited
Phenotypic Abnormality (PA)Short digit0.7308Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.000000001968Least InformativeDirect
Mammalian Phenotype (MP)hematopoietic system phenotype0.00000004019Least InformativeDirect
Mammalian Phenotype (MP)nervous system phenotype0.2466Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis1Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging1Least InformativeInherited
Mammalian Phenotype (MP)abnormal induced morbidity/mortality0.06592Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.1724Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0.993Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology1Moderately InformativeInherited
Mammalian Phenotype (MP)autoimmune response0.00000000288InformativeDirect
Mammalian Phenotype (MP)abnormal innervation0.0006125InformativeDirect
Mammalian Phenotype (MP)abnormal female reproductive gland morphology0.9376InformativeInherited
Mammalian Phenotype (MP)abnormal internal female genitalia morphology0.9857InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to infection induced morbidity/mortality0.0002494Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell morphology variant0.0001023Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.001251Least InformativeInherited
Worm Phenotype (WP)cell development variant0.05121Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.06375Least InformativeInherited
Worm Phenotype (WP)blast cell physiology variant0.6326Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.6335Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.9266Least InformativeInherited
Worm Phenotype (WP)organism behavior variant1Least InformativeInherited
Worm Phenotype (WP)neuron development variant0.000000001217Moderately InformativeDirect
Worm Phenotype (WP)body morphology variant0.0000005917Moderately InformativeDirect
Worm Phenotype (WP)nervous system morphology variant0.00005585Moderately InformativeDirect
Worm Phenotype (WP)movement variant0.00005784Moderately InformativeDirect
Worm Phenotype (WP)reproductive system development variant0.00066Moderately InformativeDirect
Worm Phenotype (WP)body region morphology variant0.00144Moderately InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.00144Moderately InformativeInherited
Worm Phenotype (WP)developmental morphology variant0.001454Moderately InformativeInherited
Worm Phenotype (WP)adult body morphology variant0.001468Moderately InformativeInherited
Worm Phenotype (WP)drug response variant0.006234Moderately InformativeInherited
Worm Phenotype (WP)locomotion variant0.01906Moderately InformativeInherited
Worm Phenotype (WP)metabolic pathway variant0.0398Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.1581Moderately InformativeInherited
Worm Phenotype (WP)germ cell morphology variant1Moderately InformativeInherited
Worm Phenotype (WP)anchor cell invasion variant0InformativeDirect
Worm Phenotype (WP)axon outgrowth variant0.0000000001575InformativeDirect
Worm Phenotype (WP)body posture variant0.00001199InformativeDirect
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.00002992InformativeDirect
Worm Phenotype (WP)aldicarb response variant0.00006084InformativeDirect
Worm Phenotype (WP)locomotion reduced0.0002137InformativeDirect
Worm Phenotype (WP)neuron morphology variant0.0002751InformativeDirect
Worm Phenotype (WP)tail morphology variant0.000542InformativeDirect
Worm Phenotype (WP)mitochondria morphology variant0.0008378InformativeDirect
Worm Phenotype (WP)protein metabolism variant0.01849InformativeInherited
Worm Phenotype (WP)neuron migration variant0.6164InformativeInherited
Worm Phenotype (WP)epithelial system development variant0.7258InformativeInherited
Worm Phenotype (WP)muscle arm development defective0.0000000002555Highly InformativeDirect
Worm Phenotype (WP)synapse morphology variant0.00000223Highly InformativeDirect
Worm Phenotype (WP)protein degradation variant0.00004202Highly InformativeDirect
Worm Phenotype (WP)growth rate variant0.0001077Highly InformativeDirect
Worm Phenotype (WP)exploded through vulva0.0003975Highly InformativeDirect
Worm Phenotype (WP)neuropil development variant0.001671Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)cell migration defective0.000252Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)nervous system0.002904Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.002907Least InformativeInherited
Fly Anatomy (FA)larva0.1056Least InformativeInherited
Fly Anatomy (FA)somatic cell0.1202Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.1743Least InformativeInherited
Fly Anatomy (FA)adult0.2084Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.00000006116Moderately InformativeDirect
Fly Anatomy (FA)central nervous system0.001055Moderately InformativeInherited
Fly Anatomy (FA)ganglion0.00625Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.01343Moderately InformativeInherited
Fly Anatomy (FA)sensory system0.03132Moderately InformativeInherited
Fly Anatomy (FA)late embryo0.04012Moderately InformativeInherited
Fly Anatomy (FA)neuron0.06753Moderately InformativeInherited
Fly Anatomy (FA)adult nervous system0.1866Moderately InformativeInherited
Fly Anatomy (FA)somatic precursor cell0.3673Moderately InformativeInherited
Fly Anatomy (FA)head0.6626Moderately InformativeInherited
Fly Anatomy (FA)adult tagma0.6737Moderately InformativeInherited
Fly Anatomy (FA)larval abdomen0.000000179InformativeDirect
Fly Anatomy (FA)synaptic neuropil0.0002482InformativeDirect
Fly Anatomy (FA)nerve0.0005992InformativeDirect
Fly Anatomy (FA)embryonic/larval peripheral nervous system0.000717InformativeDirect
Fly Anatomy (FA)primordium0.006807InformativeInherited
Fly Anatomy (FA)brain0.008922InformativeInherited
Fly Anatomy (FA)larval segment0.01071InformativeInherited
Fly Anatomy (FA)syncytium0.02321InformativeInherited
Fly Anatomy (FA)ventral nerve cord0.04475InformativeInherited
Fly Anatomy (FA)abdominal segment0.05046InformativeInherited
Fly Anatomy (FA)muscle cell0.05247InformativeInherited
Fly Anatomy (FA)dorsal closure embryo0.1032InformativeInherited
Fly Anatomy (FA)adult central nervous system0.1184InformativeInherited
Fly Anatomy (FA)chemosensory system0.1217InformativeInherited
Fly Anatomy (FA)embryonic/larval muscle system0.1396InformativeInherited
Fly Anatomy (FA)tract0.5913InformativeInherited
Fly Anatomy (FA)embryonic heart cardioblast0.0000003328Highly InformativeDirect
Fly Anatomy (FA)leg taste bristle chemosensory neuron0.00004672Highly InformativeDirect
Fly Anatomy (FA)longitudinal muscle0.0001526Highly InformativeDirect
Fly Anatomy (FA)LNv neuron0.0001558Highly InformativeDirect
Fly Anatomy (FA)connective0.0001862Highly InformativeDirect
Fly Anatomy (FA)commissure0.0003621Highly InformativeDirect
Fly Anatomy (FA)heart primordium0.0004169Highly InformativeDirect
Fly Anatomy (FA)abdominal segmental nerve0.0008839Highly InformativeDirect
Fly Anatomy (FA)larval VNC neuropil glial cell0.01798Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)multi-tissue structure0.08341Least InformativeInherited
Zebrafish Anatomy (ZA)cavitated compound organ0.4855Least InformativeInherited
Zebrafish Anatomy (ZA)nervous system1Least InformativeInherited
Zebrafish Anatomy (ZA)central nervous system0.7007Moderately InformativeInherited
Zebrafish Anatomy (ZA)sensory system1Moderately InformativeInherited
Zebrafish Anatomy (ZA)forebrain0.4515InformativeInherited
Zebrafish Anatomy (ZA)medial longitudinal fasciculus0.00008871Highly InformativeDirect
Zebrafish Anatomy (ZA)glomerular layer0.00108Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)anatomical system1Least InformativeInherited
Xenopus ANatomical entity (XAN)trunk1Least InformativeInherited
Xenopus ANatomical entity (XAN)viscus1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)immune system1InformativeInherited
Xenopus DEvelopment stage (XDE)post-embryonic stage1Least InformativeInherited
Xenopus DEvelopment stage (XDE)embryonic stage0.0000008921Moderately InformativeDirect
Xenopus DEvelopment stage (XDE)adult frog stage0.0002886Highly InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.07715Moderately InformativeInherited
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0InformativeDirect
Enzyme Commission (EC)Acting on a peroxide as acceptor0.00002985InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 450 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Immunoglobulin domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 450 hidden Markov models representing the Immunoglobulin superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]