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Fibronectin type III superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Immunoglobulin-like beta-sandwich [ 48725] (28)
Superfamily:   Fibronectin type III [ 49265]
Families:   Fibronectin type III [ 49266] (44)


Superfamily statistics
Genomes (1,736) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 71,149 265,201 172
Proteins 29,622 129,837 117


Functional annotation
General category Processes_EC
Detailed category Cell adhesion

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0.000000000000007826Least InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl0.00000000004277Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.1816Moderately InformativeInherited
Enzyme Commission (EC)Receptor protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0InformativeDirect
Enzyme Commission (EC)Chitinase0.0002219Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.5691Least InformativeInherited
Disease Ontology (DO)urinary system disease0.2508Moderately InformativeInherited
Disease Ontology (DO)neurodegenerative disease0.4827Moderately InformativeInherited
Disease Ontology (DO)disease by infectious agent0.5928Moderately InformativeInherited
Disease Ontology (DO)primary bacterial infectious disease0.7034InformativeInherited
Disease Ontology (DO)acute kidney failure0.000001647Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.00753Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.2363Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.6328Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.6527Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.9236Least InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.004724Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.0254Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.1181Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development0.1589Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.2404Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.2562Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.8026Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system physiology0.919Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal circulating cytokine level0.000002524InformativeDirect
Mammalian Phenotype (MP)autoimmune response0.0001159InformativeDirect
Mammalian Phenotype (MP)abnormal cell differentiation0.002674InformativeInherited
Mammalian Phenotype (MP)abnormal heart layer morphology0.1187InformativeInherited
Mammalian Phenotype (MP)abnormal female reproductive system physiology0.2122InformativeInherited
Mammalian Phenotype (MP)abnormal white adipose tissue morphology0.3821InformativeInherited
Mammalian Phenotype (MP)abnormal interferon level0.4742InformativeInherited
Mammalian Phenotype (MP)abnormal spermatogenesis0.6054InformativeInherited
Mammalian Phenotype (MP)increased apoptosis0.8052InformativeInherited
Mammalian Phenotype (MP)abnormal adipose tissue amount0.8321InformativeInherited
Mammalian Phenotype (MP)abnormal axon guidance0.0004416Highly InformativeDirect
Mammalian Phenotype (MP)abnormal spermiogenesis0.08902Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell morphology variant0.000003812Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.0005922Least InformativeDirect
Worm Phenotype (WP)cell development variant0.0006151Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.01765Least InformativeInherited
Worm Phenotype (WP)neuron development variant0.00000002039Moderately InformativeDirect
Worm Phenotype (WP)nervous system morphology variant0.003074Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.005331Moderately InformativeInherited
Worm Phenotype (WP)reproductive system development variant0.02496Moderately InformativeInherited
Worm Phenotype (WP)axon outgrowth variant0.00000000003164InformativeDirect
Worm Phenotype (WP)anchor cell invasion variant0.00000000006859InformativeDirect
Worm Phenotype (WP)locomotion reduced0.0000079InformativeDirect
Worm Phenotype (WP)neuron morphology variant0.00005425InformativeDirect
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.00006361InformativeDirect
Worm Phenotype (WP)body posture variant0.0002237InformativeDirect
Worm Phenotype (WP)cell fate specification variant0.01236InformativeInherited
Worm Phenotype (WP)forward locomotion variant0.02992InformativeInherited
Worm Phenotype (WP)directionality variant0.5838InformativeInherited
Worm Phenotype (WP)muscle arm development defective0.000000005021Highly InformativeDirect
Worm Phenotype (WP)forward locomotion decreased0.0000446Highly InformativeDirect
Worm Phenotype (WP)axon trajectory variant0.09384Highly InformativeInherited
Worm Phenotype (WP)loss of left right asymmetry0.1323Highly InformativeInherited
Worm Phenotype (WP)neuronal cell fate specification variant0.3176Highly InformativeInherited
Worm Phenotype (WP)path curvature variant0.6924Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system subdivision0.0002465Least InformativeDirect
Fly Anatomy (FA)organism subdivision0.006002Least InformativeInherited
Fly Anatomy (FA)nervous system0.006281Least InformativeInherited
Fly Anatomy (FA)adult0.0209Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.02914Least InformativeInherited
Fly Anatomy (FA)larva0.148Least InformativeInherited
Fly Anatomy (FA)cell0.3683Least InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.0000000008471Moderately InformativeDirect
Fly Anatomy (FA)ganglion0.002111Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.005974Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.03162Moderately InformativeInherited
Fly Anatomy (FA)sensory system0.09961Moderately InformativeInherited
Fly Anatomy (FA)adult segment0.1058Moderately InformativeInherited
Fly Anatomy (FA)neuron0.2316Moderately InformativeInherited
Fly Anatomy (FA)adult tagma0.4361Moderately InformativeInherited
Fly Anatomy (FA)somatic precursor cell0.5299Moderately InformativeInherited
Fly Anatomy (FA)head0.646Moderately InformativeInherited
Fly Anatomy (FA)embryo0.7747Moderately InformativeInherited
Fly Anatomy (FA)larval abdomen0.0001943InformativeDirect
Fly Anatomy (FA)adult brain0.001524InformativeInherited
Fly Anatomy (FA)synaptic neuropil block0.001944InformativeInherited
Fly Anatomy (FA)central brain0.002653InformativeInherited
Fly Anatomy (FA)dorsal closure embryo0.01906InformativeInherited
Fly Anatomy (FA)primordium0.01932InformativeInherited
Fly Anatomy (FA)supraesophageal ganglion0.02024InformativeInherited
Fly Anatomy (FA)sensory organ cell0.03092InformativeInherited
Fly Anatomy (FA)chemosensory system0.04682InformativeInherited
Fly Anatomy (FA)labral segment0.05024InformativeInherited
Fly Anatomy (FA)adult optic lobe neuron0.05278InformativeInherited
Fly Anatomy (FA)neuromere0.07637InformativeInherited
Fly Anatomy (FA)synaptic neuropil domain0.3509InformativeInherited
Fly Anatomy (FA)tract0.3963InformativeInherited
Fly Anatomy (FA)adult procephalic segment0.544InformativeInherited
Fly Anatomy (FA)commissure0.000002948Highly InformativeDirect
Fly Anatomy (FA)lobe system of adult mushroom body0.000009476Highly InformativeDirect
Fly Anatomy (FA)LNv neuron0.00003193Highly InformativeDirect
Fly Anatomy (FA)embryonic heart cardioblast0.00003202Highly InformativeDirect
Fly Anatomy (FA)neuron projection bundle of ventral nerve cord0.0002227Highly InformativeDirect
Fly Anatomy (FA)leg taste bristle chemosensory neuron0.0006439Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)multi-tissue structure0.1259Least InformativeInherited
Zebrafish Anatomy (ZA)nervous system0.6421Least InformativeInherited
Zebrafish Anatomy (ZA)cavitated compound organ0.7028Least InformativeInherited
Zebrafish Anatomy (ZA)central nervous system0.2859Moderately InformativeInherited
Zebrafish Anatomy (ZA)sensory system0.7683Moderately InformativeInherited
Zebrafish Anatomy (ZA)forebrain0.05777InformativeInherited
Zebrafish Anatomy (ZA)medial longitudinal fasciculus0.00002039Highly InformativeDirect
Zebrafish Anatomy (ZA)olfactory system0.1178Highly InformativeInherited
Zebrafish Anatomy (ZA)telencephalon0.2274Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system0.6808Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.9228Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.9786Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue1Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.12Moderately InformativeInherited
Xenopus ANatomical entity (XAN)sensory system0.3353Moderately InformativeInherited
Xenopus ANatomical entity (XAN)eye0.3659InformativeInherited
Xenopus ANatomical entity (XAN)retinal neural layer0.0006932Highly InformativeDirect
Xenopus DEvelopment stage (XDE)embryonic stage0.0000009165Moderately InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases0.0000002887Least InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Aminoacyltransferases0.00000112Moderately InformativeDirect
Enzyme Commission (EC)Glycosylases0.00003279Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.1475Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases0.8037Moderately InformativeInherited
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0InformativeDirect
Enzyme Commission (EC)RING-type E3 ubiquitin transferase0.0000000009625InformativeDirect
Enzyme Commission (EC)Hexosyltransferases0.00001968InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0Highly InformativeDirect
Enzyme Commission (EC)Chitinase0.000916Highly InformativeDirect

Document: EC annotation of SCOP domains

InterPro annotation
Cross references IPR008957 SSF49265 Protein matches
Abstract

Fibronectin is composed of three repeating structural motifs, of which one is the FnIII module. The three modules form a linear sequence of multiple tandem copies connected by short linker peptides. The secondary structure of the FnIII10 module, which is the only fibronectin module to possess an integrin binding RGD motif, consists of two beta-sheets containing the antiparallel beta-strands ABE and DCFG, respectively, which fold up to form a beta-sandwich. The RGD sequence is located in the loop connecting the beta-strands [PubMed9990027].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 169 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Fibronectin type III domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 169 hidden Markov models representing the Fibronectin type III superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]