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Fibronectin type III superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Immunoglobulin-like beta-sandwich [ 48725] (28)
Superfamily:   Fibronectin type III [ 49265]
Families:   Fibronectin type III [ 49266] (44)

Superfamily statistics
Genomes (1,736) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 71,149 265,201 172
Proteins 29,622 129,837 117

Functional annotation
General category Processes_EC
Detailed category Cell adhesion

Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0.000000000000007826Least InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl0.00000000004277Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.1816Moderately InformativeInherited
Enzyme Commission (EC)Receptor protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0InformativeDirect
Enzyme Commission (EC)Chitinase0.0002219Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.5337Least InformativeInherited
Disease Ontology (DO)urinary system disease0.235Moderately InformativeInherited
Disease Ontology (DO)neurodegenerative disease0.4836Moderately InformativeInherited
Disease Ontology (DO)disease by infectious agent0.5738Moderately InformativeInherited
Disease Ontology (DO)primary bacterial infectious disease0.7038InformativeInherited
Disease Ontology (DO)acute kidney failure0.000001623Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.007497Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.2368Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.6371Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.6549Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.9234Least InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.004713Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.02556Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.1204Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development0.1595Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.2398Moderately InformativeInherited
Mammalian Phenotype (MP)reproductive system phenotype0.531Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.8025Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal circulating cytokine level0.000002403InformativeDirect
Mammalian Phenotype (MP)autoimmune response0.0001171InformativeDirect
Mammalian Phenotype (MP)abnormal cell differentiation0.002711InformativeInherited
Mammalian Phenotype (MP)abnormal heart layer morphology0.1193InformativeInherited
Mammalian Phenotype (MP)abnormal female reproductive system physiology0.2129InformativeInherited
Mammalian Phenotype (MP)abnormal white adipose tissue morphology0.3795InformativeInherited
Mammalian Phenotype (MP)abnormal interferon level0.4774InformativeInherited
Mammalian Phenotype (MP)abnormal spermatogenesis0.6091InformativeInherited
Mammalian Phenotype (MP)increased apoptosis0.806InformativeInherited
Mammalian Phenotype (MP)abnormal adipose tissue amount0.8313InformativeInherited
Mammalian Phenotype (MP)abnormal axon guidance0.0004411Highly InformativeDirect
Mammalian Phenotype (MP)abnormal spermiogenesis0.08925Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell morphology variant0.00004081Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.0003438Least InformativeDirect
Worm Phenotype (WP)cell development variant0.001271Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.007613Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.03931Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.1931Least InformativeInherited
Worm Phenotype (WP)nervous system morphology variant0.0017Moderately InformativeInherited
Worm Phenotype (WP)metabolic pathway variant0.001869Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.01072Moderately InformativeInherited
Worm Phenotype (WP)reproductive system development variant0.02683Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.04452Moderately InformativeInherited
Worm Phenotype (WP)cell component morphology variant0.99Moderately InformativeInherited
Worm Phenotype (WP)protein degradation variant0.000004786InformativeDirect
Worm Phenotype (WP)locomotion reduced0.000004979InformativeDirect
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.00005616InformativeDirect
Worm Phenotype (WP)body posture variant0.0002802InformativeDirect
Worm Phenotype (WP)mitochondria morphology variant0.0003265InformativeDirect
Worm Phenotype (WP)growth rate variant0.0009935InformativeDirect
Worm Phenotype (WP)locomotor coordination variant0.001973InformativeInherited
Worm Phenotype (WP)muscle cell physiology variant0.004619InformativeInherited
Worm Phenotype (WP)neuronal outgrowth variant0.00859InformativeInherited
Worm Phenotype (WP)forward locomotion variant0.02573InformativeInherited
Worm Phenotype (WP)anchor cell invasion variant0.00000000003831Highly InformativeDirect
Worm Phenotype (WP)muscle arm development defective0.000000005062Highly InformativeDirect
Worm Phenotype (WP)forward locomotion decreased0.0000408Highly InformativeDirect
Worm Phenotype (WP)loss of left right asymmetry0.09582Highly InformativeInherited
Worm Phenotype (WP)axon development variant0.1949Highly InformativeInherited
Worm Phenotype (WP)neuronal cell fate specification variant0.1961Highly InformativeInherited
Worm Phenotype (WP)path curvature variant0.7274Highly InformativeInherited
Worm Phenotype (WP)axon morphology variant0.7754Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system subdivision0.0003034Least InformativeDirect
Fly Anatomy (FA)anatomical group0.001735Least InformativeInherited
Fly Anatomy (FA)embryo0.02319Least InformativeInherited
Fly Anatomy (FA)nervous system0.02995Least InformativeInherited
Fly Anatomy (FA)larva0.03603Least InformativeInherited
Fly Anatomy (FA)adult0.1189Least InformativeInherited
Fly Anatomy (FA)somatic cell0.3244Least InformativeInherited
Fly Anatomy (FA)integumentary system0.433Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.00000002301Moderately InformativeDirect
Fly Anatomy (FA)central nervous system0.01497Moderately InformativeInherited
Fly Anatomy (FA)sensory neuron0.02524Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.0297Moderately InformativeInherited
Fly Anatomy (FA)late embryo0.06559Moderately InformativeInherited
Fly Anatomy (FA)cell cluster organ0.1105Moderately InformativeInherited
Fly Anatomy (FA)sense organ0.1922Moderately InformativeInherited
Fly Anatomy (FA)adult segment0.2043Moderately InformativeInherited
Fly Anatomy (FA)adult thorax0.7309Moderately InformativeInherited
Fly Anatomy (FA)appendage0.9448Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.9698Moderately InformativeInherited
Fly Anatomy (FA)thoracic segment1Moderately InformativeInherited
Fly Anatomy (FA)tagmatic subdivision of integument1Moderately InformativeInherited
Fly Anatomy (FA)larval abdomen0.0000005244InformativeDirect
Fly Anatomy (FA)synaptic neuropil0.0001482InformativeDirect
Fly Anatomy (FA)nerve0.000587InformativeDirect
Fly Anatomy (FA)chemosensory system0.02859InformativeInherited
Fly Anatomy (FA)chaeta0.09318InformativeInherited
Fly Anatomy (FA)leg0.3007InformativeInherited
Fly Anatomy (FA)midline crossing tract0.4221InformativeInherited
Fly Anatomy (FA)prothoracic leg taste bristle chemosensory neuron0.00001198Highly InformativeDirect
Fly Anatomy (FA)commissure0.00002302Highly InformativeDirect
Fly Anatomy (FA)multidendritic neuron0.04671Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)compound organ0.03225Least InformativeInherited
Zebrafish Anatomy (ZA)multi-tissue structure0.1222Least InformativeInherited
Zebrafish Anatomy (ZA)nervous system0.6252Least InformativeInherited
Zebrafish Anatomy (ZA)central nervous system0.2707Moderately InformativeInherited
Zebrafish Anatomy (ZA)brain0.3621InformativeInherited
Zebrafish Anatomy (ZA)medial longitudinal fasciculus0.0003422Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system0.6627Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.9313Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.9847Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue1Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.09348Moderately InformativeInherited
Xenopus ANatomical entity (XAN)sensory system0.3233Moderately InformativeInherited
Xenopus ANatomical entity (XAN)eye0.5583InformativeInherited
Xenopus ANatomical entity (XAN)retinal ganglion cell layer0.0006005Highly InformativeDirect
Xenopus DEvelopment stage (XDE)embryonic stage0.0000172Moderately InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases0.000008836Least InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosylases0.00002348Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.1227Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases0.7651Moderately InformativeInherited
Enzyme Commission (EC)Acyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0InformativeDirect
Enzyme Commission (EC)RING-type E3 ubiquitin transferase0.0000000005404InformativeDirect
Enzyme Commission (EC)Hexosyltransferases0.0000151InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0Highly InformativeDirect
Enzyme Commission (EC)Chitinase0.0005539Highly InformativeDirect

Document: EC annotation of SCOP domains

InterPro annotation
Cross references IPR008957 SSF49265 Protein matches

Fibronectin is composed of three repeating structural motifs, of which one is the FnIII module. The three modules form a linear sequence of multiple tandem copies connected by short linker peptides. The secondary structure of the FnIII10 module, which is the only fibronectin module to possess an integrin binding RGD motif, consists of two beta-sheets containing the antiparallel beta-strands ABE and DCFG, respectively, which fold up to form a beta-sandwich. The RGD sequence is located in the loop connecting the beta-strands [PubMed9990027].

InterPro database

PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 111 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Browse and view proteins in genomes which have different domain combinations including a Fibronectin type III domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 111 hidden Markov models representing the Fibronectin type III superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]