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Fibronectin type III superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Immunoglobulin-like beta-sandwich [ 48725] (28)
Superfamily:   Fibronectin type III [ 49265]
Families:   Fibronectin type III [ 49266] (44)


Superfamily statistics
Genomes (1,736) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 71,149 265,201 172
Proteins 29,622 129,837 117


Functional annotation
General category Processes_EC
Detailed category Cell adhesion

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0.000000000000007826Least InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl0.00000000004277Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.1816Moderately InformativeInherited
Enzyme Commission (EC)Receptor protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0InformativeDirect
Enzyme Commission (EC)Chitinase0.0002219Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.5328Least InformativeInherited
Disease Ontology (DO)urinary system disease0.2375Moderately InformativeInherited
Disease Ontology (DO)neurodegenerative disease0.4837Moderately InformativeInherited
Disease Ontology (DO)disease by infectious agent0.575Moderately InformativeInherited
Disease Ontology (DO)primary bacterial infectious disease0.7032InformativeInherited
Disease Ontology (DO)acute kidney failure0.000001648Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.007542Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.2364Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.6367Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.6546Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.9234Least InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.004706Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.02556Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.1196Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development0.1603Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.2396Moderately InformativeInherited
Mammalian Phenotype (MP)reproductive system phenotype0.5306Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.8025Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal circulating cytokine level0.000002404InformativeDirect
Mammalian Phenotype (MP)autoimmune response0.0001169InformativeDirect
Mammalian Phenotype (MP)abnormal cell differentiation0.002707InformativeInherited
Mammalian Phenotype (MP)abnormal heart layer morphology0.1192InformativeInherited
Mammalian Phenotype (MP)abnormal female reproductive system physiology0.2128InformativeInherited
Mammalian Phenotype (MP)abnormal white adipose tissue morphology0.3793InformativeInherited
Mammalian Phenotype (MP)abnormal interferon level0.4773InformativeInherited
Mammalian Phenotype (MP)abnormal spermatogenesis0.6088InformativeInherited
Mammalian Phenotype (MP)increased apoptosis0.8059InformativeInherited
Mammalian Phenotype (MP)abnormal adipose tissue amount0.8312InformativeInherited
Mammalian Phenotype (MP)abnormal axon guidance0.0004414Highly InformativeDirect
Mammalian Phenotype (MP)abnormal spermiogenesis0.0892Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell morphology variant0.00001019Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.00035Least InformativeDirect
Worm Phenotype (WP)cell development variant0.001194Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.007343Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.03886Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.1872Least InformativeInherited
Worm Phenotype (WP)nervous system morphology variant0.002322Moderately InformativeInherited
Worm Phenotype (WP)metabolic pathway variant0.002499Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.01026Moderately InformativeInherited
Worm Phenotype (WP)reproductive system development variant0.02783Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.05038Moderately InformativeInherited
Worm Phenotype (WP)cell component morphology variant1Moderately InformativeInherited
Worm Phenotype (WP)axon outgrowth variant0.00000000001291InformativeDirect
Worm Phenotype (WP)anchor cell invasion variant0.00000000005776InformativeDirect
Worm Phenotype (WP)neurite morphology variant0.000000000991InformativeDirect
Worm Phenotype (WP)locomotion reduced0.00000541InformativeDirect
Worm Phenotype (WP)protein degradation variant0.000005642InformativeDirect
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.00005112InformativeDirect
Worm Phenotype (WP)body posture variant0.0002901InformativeDirect
Worm Phenotype (WP)mitochondria morphology variant0.0003408InformativeDirect
Worm Phenotype (WP)locomotor coordination variant0.002106InformativeInherited
Worm Phenotype (WP)muscle cell physiology variant0.004543InformativeInherited
Worm Phenotype (WP)forward locomotion variant0.03031InformativeInherited
Worm Phenotype (WP)muscle arm development defective0.000000005147Highly InformativeDirect
Worm Phenotype (WP)forward locomotion decreased0.00004119Highly InformativeDirect
Worm Phenotype (WP)axon trajectory variant0.02367Highly InformativeInherited
Worm Phenotype (WP)loss of left right asymmetry0.09558Highly InformativeInherited
Worm Phenotype (WP)neuronal cell fate specification variant0.2102Highly InformativeInherited
Worm Phenotype (WP)path curvature variant0.7302Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)cell adhesion defective0.00008966Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system subdivision0.0001654Least InformativeDirect
Fly Anatomy (FA)anatomical group0.0007082Least InformativeDirect
Fly Anatomy (FA)nervous system0.01631Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.01753Least InformativeInherited
Fly Anatomy (FA)larva0.01979Least InformativeInherited
Fly Anatomy (FA)adult0.1321Least InformativeInherited
Fly Anatomy (FA)somatic cell0.271Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.0000000004675Moderately InformativeDirect
Fly Anatomy (FA)ganglion0.001527Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.004071Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.02337Moderately InformativeInherited
Fly Anatomy (FA)late embryo0.07493Moderately InformativeInherited
Fly Anatomy (FA)cell cluster organ0.08724Moderately InformativeInherited
Fly Anatomy (FA)developing embryonic structure0.1067Moderately InformativeInherited
Fly Anatomy (FA)sense organ0.1468Moderately InformativeInherited
Fly Anatomy (FA)adult segment0.1687Moderately InformativeInherited
Fly Anatomy (FA)neuron0.2925Moderately InformativeInherited
Fly Anatomy (FA)somatic precursor cell0.5789Moderately InformativeInherited
Fly Anatomy (FA)adult thorax0.6455Moderately InformativeInherited
Fly Anatomy (FA)head0.696Moderately InformativeInherited
Fly Anatomy (FA)appendage0.9325Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.9335Moderately InformativeInherited
Fly Anatomy (FA)thoracic segment1Moderately InformativeInherited
Fly Anatomy (FA)tagmatic subdivision of integument1Moderately InformativeInherited
Fly Anatomy (FA)larval abdomen0.0000004285InformativeDirect
Fly Anatomy (FA)nerve0.0006251InformativeDirect
Fly Anatomy (FA)primordium0.01504InformativeInherited
Fly Anatomy (FA)adult procephalic segment0.01851InformativeInherited
Fly Anatomy (FA)chemosensory system0.03194InformativeInherited
Fly Anatomy (FA)labral segment0.04271InformativeInherited
Fly Anatomy (FA)brain0.0438InformativeInherited
Fly Anatomy (FA)chaeta0.07585InformativeInherited
Fly Anatomy (FA)neuromere0.1011InformativeInherited
Fly Anatomy (FA)dorsal closure embryo0.1133InformativeInherited
Fly Anatomy (FA)adult central nervous system0.1324InformativeInherited
Fly Anatomy (FA)leg0.298InformativeInherited
Fly Anatomy (FA)synaptic neuropil domain0.4306InformativeInherited
Fly Anatomy (FA)tract0.4529InformativeInherited
Fly Anatomy (FA)prothoracic leg taste bristle chemosensory neuron0.00001016Highly InformativeDirect
Fly Anatomy (FA)embryonic heart cardioblast0.0000132Highly InformativeDirect
Fly Anatomy (FA)commissure0.0000153Highly InformativeDirect
Fly Anatomy (FA)lobe system of adult mushroom body0.00012Highly InformativeDirect
Fly Anatomy (FA)LNv neuron0.0001386Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)compound organ0.1115Least InformativeInherited
Zebrafish Anatomy (ZA)multi-tissue structure0.1121Least InformativeInherited
Zebrafish Anatomy (ZA)nervous system0.6159Least InformativeInherited
Zebrafish Anatomy (ZA)central nervous system0.2405Moderately InformativeInherited
Zebrafish Anatomy (ZA)sensory system0.6996Moderately InformativeInherited
Zebrafish Anatomy (ZA)forebrain0.03501InformativeInherited
Zebrafish Anatomy (ZA)medial longitudinal fasciculus0.00001835Highly InformativeDirect
Zebrafish Anatomy (ZA)glomerular layer0.000338Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system0.7356Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.923Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.9819Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue1Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.106Moderately InformativeInherited
Xenopus ANatomical entity (XAN)sensory system0.311Moderately InformativeInherited
Xenopus ANatomical entity (XAN)eye0.3525InformativeInherited
Xenopus ANatomical entity (XAN)retinal ganglion cell layer0.0003145Highly InformativeDirect
Xenopus DEvelopment stage (XDE)embryonic stage0.000002254Moderately InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases0.0000007054Least InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Aminoacyltransferases0.0000008911Moderately InformativeDirect
Enzyme Commission (EC)Glycosylases0.00006132Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.1253Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases0.7666Moderately InformativeInherited
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0InformativeDirect
Enzyme Commission (EC)RING-type E3 ubiquitin transferase0.0000000006914InformativeDirect
Enzyme Commission (EC)Hexosyltransferases0.0000174InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0Highly InformativeDirect
Enzyme Commission (EC)Chitinase0.000644Highly InformativeDirect

Document: EC annotation of SCOP domains

InterPro annotation
Cross references IPR008957 SSF49265 Protein matches
Abstract

Fibronectin is composed of three repeating structural motifs, of which one is the FnIII module. The three modules form a linear sequence of multiple tandem copies connected by short linker peptides. The secondary structure of the FnIII10 module, which is the only fibronectin module to possess an integrin binding RGD motif, consists of two beta-sheets containing the antiparallel beta-strands ABE and DCFG, respectively, which fold up to form a beta-sandwich. The RGD sequence is located in the loop connecting the beta-strands [PubMed9990027].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 169 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Fibronectin type III domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 169 hidden Markov models representing the Fibronectin type III superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]