SUPERFAMILY 1.75 HMM library and genome assignments server

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Fibronectin type III superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Immunoglobulin-like beta-sandwich [ 48725] (28)
Superfamily:   Fibronectin type III [ 49265]
Families:   Fibronectin type III [ 49266] (44)


Superfamily statistics
Genomes (1,727) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 70,136 91,738 172
Proteins 29,144 47,558 117


Functional annotation
General category Processes_EC
Detailed category Cell adhesion

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process0.00000061670.000003365Least InformativeDirect
Biological Process (BP)multicellular organismal process0.000081090Least InformativeDirect
Biological Process (BP)single-organism cellular process0.00027630Least InformativeDirect
Biological Process (BP)response to stimulus0.00030420Least InformativeDirect
Biological Process (BP)developmental process0.0013740Least InformativeInherited
Biological Process (BP)localization0.055440.0000000002496Least InformativeInherited
Biological Process (BP)cell differentiation0.0000098150.0000000004912Moderately InformativeDirect
Biological Process (BP)reproduction0.000030570.0003623Moderately InformativeDirect
Biological Process (BP)regulation of multicellular organismal process0.00088390Moderately InformativeDirect
Biological Process (BP)tissue development0.0014771Moderately InformativeInherited
Biological Process (BP)organ development0.048920.03501Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.46940.5056Moderately InformativeInherited
Biological Process (BP)response to endogenous stimulus0.057091Moderately InformativeInherited
Biological Process (BP)response to organic substance0.000000066911Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.00011390.4858Moderately InformativeInherited
Biological Process (BP)signal transduction0.0014710Moderately InformativeInherited
Biological Process (BP)response to cytokine stimulus0.000000000000024560InformativeDirect
Biological Process (BP)regulation of body fluid levels0.00021130.0000000000002252InformativeDirect
Biological Process (BP)growth0.00051850InformativeDirect
Biological Process (BP)gland development0.000001270.4753InformativeInherited
Biological Process (BP)epithelium development0.00000022490.4642InformativeInherited
Biological Process (BP)cellular response to endogenous stimulus0.00017350.009411InformativeInherited
Biological Process (BP)response to hormone stimulus0.43481InformativeInherited
Biological Process (BP)reproductive system development0.000026621InformativeInherited
Biological Process (BP)developmental process involved in reproduction0.000074211InformativeInherited
Biological Process (BP)multicellular organismal reproductive process0.040990.001289InformativeInherited
Biological Process (BP)intracellular signal transduction0.40631InformativeInherited
Biological Process (BP)cytokine-mediated signaling pathway00Highly InformativeDirect
Biological Process (BP)mammary gland alveolus development0.00000008630.0004891Highly InformativeDirect
Biological Process (BP)regulation of cell adhesion0.000013810Highly InformativeDirect
Biological Process (BP)lactation0.00002820.00009321Highly InformativeDirect
Biological Process (BP)mammary gland epithelium development0.00019870.0003456Highly InformativeDirect
Biological Process (BP)developmental growth0.00025770.0000000009103Highly InformativeDirect
Biological Process (BP)hormone-mediated signaling pathway0.0021521Highly InformativeInherited
Molecular Function (MF)binding0.0056040Least InformativeInherited
Molecular Function (MF)receptor activity0.00000000095990InformativeDirect
Molecular Function (MF)molecular transducer activity0.0000000019920InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 0.000003365 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) localization 0.0000000002496 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0 Least Informative Direct
Biological Process (BP) protein metabolic process 0 Least Informative Direct
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cell differentiation 0.0000000004912 Moderately Informative Direct
Biological Process (BP) reproduction 0.0003623 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0 Moderately Informative Direct
Biological Process (BP) signal transduction 0 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0.00000000009105 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0 Moderately Informative Direct
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0 Moderately Informative Direct
Biological Process (BP) nervous system development 0 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.000000000002452 Moderately Informative Direct
Biological Process (BP) system process 0.000006733 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.00005522 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.7923 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.5056 Moderately Informative Inherited
Biological Process (BP) organ development 0.03501 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.2734 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.4858 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.5244 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to cytokine stimulus 0 Informative Direct
Biological Process (BP) regulation of body fluid levels 0.0000000000002252 Informative Direct
Biological Process (BP) growth 0 Informative Direct
Biological Process (BP) cellular component movement 0 Informative Direct
Biological Process (BP) central nervous system development 0 Informative Direct
Biological Process (BP) biological adhesion 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) cell projection organization 0 Informative Direct
Biological Process (BP) localization of cell 0 Informative Direct
Biological Process (BP) response to wounding 0 Informative Direct
Biological Process (BP) generation of neurons 0 Informative Direct
Biological Process (BP) cellular component morphogenesis 0 Informative Direct
Biological Process (BP) dephosphorylation 0.000000000000003755 Informative Direct
Biological Process (BP) regulation of nervous system development 0.00000000000001435 Informative Direct
Biological Process (BP) negative regulation of immune system process 0.0000000000000161 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0.0000000000001766 Informative Direct
Biological Process (BP) regulation of cell development 0.0000000000004423 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.000000000001086 Informative Direct
Biological Process (BP) positive regulation of developmental process 0.000000000003876 Informative Direct
Biological Process (BP) phosphorylation 0.00000000000443 Informative Direct
Biological Process (BP) blood circulation 0.00000000106 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.00000002061 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.0000001817 Informative Direct
Biological Process (BP) defense response 0.0000005374 Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 0.000001029 Informative Direct
Biological Process (BP) regulation of locomotion 0.000001564 Informative Direct
Biological Process (BP) regulation of cell activation 0.000002311 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.00000333 Informative Direct
Biological Process (BP) cytoskeleton organization 0.000004449 Informative Direct
Biological Process (BP) organelle assembly 0.00001683 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.00001925 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.00004415 Informative Direct
Biological Process (BP) response to bacterium 0.00005333 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0.00005822 Informative Direct
Biological Process (BP) regulation of cell proliferation 0.000119 Informative Direct
Biological Process (BP) positive regulation of protein metabolic process 0.0002165 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0.000428 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0.0005715 Informative Direct
Biological Process (BP) regulation of peptidase activity 0.0008603 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0.4359 Informative Inherited
Biological Process (BP) epithelium development 0.4642 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.009411 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 1 Informative Inherited
Biological Process (BP) response to organonitrogen compound 1 Informative Inherited
Biological Process (BP) response to hormone stimulus 1 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.5744 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.9016 Informative Inherited
Biological Process (BP) tissue morphogenesis 1 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 1 Informative Inherited
Biological Process (BP) gland development 0.4753 Informative Inherited
Biological Process (BP) metal ion transport 1 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 1 Informative Inherited
Biological Process (BP) cytoplasmic transport 1 Informative Inherited
Biological Process (BP) cation homeostasis 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.5594 Informative Inherited
Biological Process (BP) protein oligomerization 0.1037 Informative Inherited
Biological Process (BP) synaptic transmission 1 Informative Inherited
Biological Process (BP) regulation of defense response 0.7213 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.01766 Informative Inherited
Biological Process (BP) sensory organ development 0.9701 Informative Inherited
Biological Process (BP) organ morphogenesis 0.5275 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.1715 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.6545 Informative Inherited
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 1 Informative Inherited
Biological Process (BP) regulation of growth 0.2353 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.3837 Informative Inherited
Biological Process (BP) cellular membrane organization 1 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.8039 Informative Inherited
Biological Process (BP) regulation of kinase activity 1 Informative Inherited
Biological Process (BP) negative regulation of cell death 0.001735 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.02 Informative Inherited
Biological Process (BP) immune response 0.8319 Informative Inherited
Biological Process (BP) immune effector process 0.04729 Informative Inherited
Biological Process (BP) secondary metabolic process 0.6768 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.00302 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.009774 Informative Inherited
Biological Process (BP) regulation of cytokine production 1 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.05232 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.001541 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 1 Informative Inherited
Biological Process (BP) reproductive system development 1 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) actin filament-based process 0.03576 Informative Inherited
Biological Process (BP) muscle structure development 0.02266 Informative Inherited
Biological Process (BP) leukocyte activation 0.1301 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.9253 Informative Inherited
Biological Process (BP) muscle tissue development 0.05784 Informative Inherited
Biological Process (BP) embryonic morphogenesis 1 Informative Inherited
Biological Process (BP) single-organism behavior 0.8912 Informative Inherited
Biological Process (BP) sexual reproduction 0.1013 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.001289 Informative Inherited
Biological Process (BP) single organism reproductive process 0.6958 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.2044 Informative Inherited
Biological Process (BP) muscle system process 0.1518 Informative Inherited
Biological Process (BP) apoptotic process 0.01247 Informative Inherited
Biological Process (BP) glycerolipid metabolic process 0.7616 Informative Inherited
Biological Process (BP) pigment metabolic process 0.04678 Informative Inherited
Biological Process (BP) energy derivation by oxidation of organic compounds 0.4129 Informative Inherited
Biological Process (BP) polysaccharide metabolic process 1 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 1 Informative Inherited
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) regulation of immune effector process 0.001307 Informative Inherited
Biological Process (BP) regulation of immune response 0.8317 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.936 Informative Inherited
Biological Process (BP) cytokine-mediated signaling pathway 0 Highly Informative Direct
Biological Process (BP) mammary gland alveolus development 0.0004891 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 0 Highly Informative Direct
Biological Process (BP) lactation 0.00009321 Highly Informative Direct
Biological Process (BP) mammary gland epithelium development 0.0003456 Highly Informative Direct
Biological Process (BP) developmental growth 0.0000000009103 Highly Informative Direct
Biological Process (BP) protein phosphorylation 0 Highly Informative Direct
Biological Process (BP) phagocytosis 0 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 0 Highly Informative Direct
Biological Process (BP) chemotaxis 0 Highly Informative Direct
Biological Process (BP) neuron projection development 0 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0 Highly Informative Direct
Biological Process (BP) cell adhesion 0 Highly Informative Direct
Biological Process (BP) regulation of neuron projection development 0 Highly Informative Direct
Biological Process (BP) protein dephosphorylation 0 Highly Informative Direct
Biological Process (BP) cell growth 0 Highly Informative Direct
Biological Process (BP) cell junction organization 0.0000000000001052 Highly Informative Direct
Biological Process (BP) negative regulation of immune response 0.000000000009624 Highly Informative Direct
Biological Process (BP) negative regulation of response to external stimulus 0.00000000003768 Highly Informative Direct
Biological Process (BP) regulation of mononuclear cell proliferation 0.00000000006947 Highly Informative Direct
Biological Process (BP) actomyosin structure organization 0.0000000007846 Highly Informative Direct
Biological Process (BP) spermatogenesis 0.000000002315 Highly Informative Direct
Biological Process (BP) regulation of toll-like receptor signaling pathway 0.000000004312 Highly Informative Direct
Biological Process (BP) negative regulation of neuron death 0.00000001248 Highly Informative Direct
Biological Process (BP) cell part morphogenesis 0.00000001537 Highly Informative Direct
Biological Process (BP) regulation of Rho protein signal transduction 0.00000002685 Highly Informative Direct
Biological Process (BP) negative regulation of locomotion 0.00000002778 Highly Informative Direct
Biological Process (BP) regulation of neuron apoptotic process 0.000000104 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.0000001793 Highly Informative Direct
Biological Process (BP) eye morphogenesis 0.000000395 Highly Informative Direct
Biological Process (BP) negative regulation of cellular component movement 0.000000649 Highly Informative Direct
Biological Process (BP) cellular response to peptide 0.000006758 Highly Informative Direct
Biological Process (BP) positive regulation of cell activation 0.000007411 Highly Informative Direct
Biological Process (BP) regulation of Ras GTPase activity 0.00001084 Highly Informative Direct
Biological Process (BP) regulation of protein kinase B signaling cascade 0.00001162 Highly Informative Direct
Biological Process (BP) regulation of peptidyl-tyrosine phosphorylation 0.000015 Highly Informative Direct
Biological Process (BP) coagulation 0.00001907 Highly Informative Direct
Biological Process (BP) regulation of cell size 0.00004483 Highly Informative Direct
Biological Process (BP) sensory perception 0.00006689 Highly Informative Direct
Biological Process (BP) protein tetramerization 0.0001456 Highly Informative Direct
Biological Process (BP) energy reserve metabolic process 0.0002179 Highly Informative Direct
Biological Process (BP) positive regulation of adaptive immune response 0.0004512 Highly Informative Direct
Biological Process (BP) learning or memory 0.0006896 Highly Informative Direct
Biological Process (BP) leukocyte proliferation 0.0008774 Highly Informative Direct
Biological Process (BP) positive regulation of endopeptidase activity 0.3779 Highly Informative Inherited
Biological Process (BP) renal system development 0.5615 Highly Informative Inherited
Biological Process (BP) response to peptide hormone stimulus 0.001369 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.908 Highly Informative Inherited
Biological Process (BP) actin filament-based movement 1 Highly Informative Inherited
Biological Process (BP) calcium ion transport 0.5208 Highly Informative Inherited
Biological Process (BP) cellular calcium ion homeostasis 0.1992 Highly Informative Inherited
Biological Process (BP) response to virus 0.09818 Highly Informative Inherited
Biological Process (BP) regulation of actin cytoskeleton organization 0.002093 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.08247 Highly Informative Inherited
Biological Process (BP) regulation of ion homeostasis 0.2612 Highly Informative Inherited
Biological Process (BP) immune response-activating signal transduction 0.07882 Highly Informative Inherited
Biological Process (BP) immune response-regulating cell surface receptor signaling pathway 1 Highly Informative Inherited
Biological Process (BP) regulation of production of molecular mediator of immune response 0.1786 Highly Informative Inherited
Biological Process (BP) cell fate commitment 1 Highly Informative Inherited
Biological Process (BP) regulation of innate immune response 0.3238 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.006501 Highly Informative Inherited
Biological Process (BP) positive regulation of neurogenesis 0.1481 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.5981 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 0.8516 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 0.5585 Highly Informative Inherited
Biological Process (BP) response to alcohol 1 Highly Informative Inherited
Biological Process (BP) positive regulation of lipid metabolic process 0.04222 Highly Informative Inherited
Biological Process (BP) negative regulation of apoptotic process 0.07239 Highly Informative Inherited
Biological Process (BP) T cell differentiation 0.7782 Highly Informative Inherited
Biological Process (BP) regulation of cysteine-type endopeptidase activity involved in apoptotic process 0.001543 Highly Informative Inherited
Biological Process (BP) B cell activation 0.3842 Highly Informative Inherited
Biological Process (BP) hormone-mediated signaling pathway 1 Highly Informative Inherited
Biological Process (BP) pattern specification process 1 Highly Informative Inherited
Biological Process (BP) innate immune response 1 Highly Informative Inherited
Biological Process (BP) multicellular organismal metabolic process 0.002183 Highly Informative Inherited
Biological Process (BP) positive regulation of leukocyte proliferation 0.003394 Highly Informative Inherited
Biological Process (BP) positive regulation of GTPase activity 1 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.0707 Highly Informative Inherited
Biological Process (BP) negative regulation of phosphorylation 0.06749 Highly Informative Inherited
Biological Process (BP) negative regulation of protein modification process 0.1175 Highly Informative Inherited
Biological Process (BP) development of primary female sexual characteristics 0.8431 Highly Informative Inherited
Biological Process (BP) cellular component assembly involved in morphogenesis 0.01382 Highly Informative Inherited
Biological Process (BP) glycosaminoglycan metabolic process 1 Highly Informative Inherited
Biological Process (BP) wound healing 0.01365 Highly Informative Inherited
Biological Process (BP) hemostasis 1 Highly Informative Inherited
Biological Process (BP) cell projection assembly 0.8443 Highly Informative Inherited
Biological Process (BP) telencephalon development 0.004024 Highly Informative Inherited
Biological Process (BP) peptidyl-serine modification 1 Highly Informative Inherited
Biological Process (BP) regulation of angiogenesis 0.03308 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.6604 Highly Informative Inherited
Biological Process (BP) retina development in camera-type eye 0.342 Highly Informative Inherited
Biological Process (BP) respiratory system development 1 Highly Informative Inherited
Biological Process (BP) acylglycerol metabolic process 0.002182 Highly Informative Inherited
Biological Process (BP) phenol-containing compound metabolic process 0.001023 Highly Informative Inherited
Biological Process (BP) protein glycosylation 1 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.08388 Highly Informative Inherited
Biological Process (BP) regulation of blood pressure 0.00138 Highly Informative Inherited
Biological Process (BP) regulation of humoral immune response 0.2531 Highly Informative Inherited
Biological Process (BP) positive regulation of lymphocyte mediated immunity 1 Highly Informative Inherited
Biological Process (BP) negative regulation of immune effector process 0.1654 Highly Informative Inherited
Biological Process (BP) leukocyte migration 0.01075 Highly Informative Inherited
Biological Process (BP) inflammatory response 0.03058 Highly Informative Inherited
Biological Process (BP) protein processing 0.1899 Highly Informative Inherited
Biological Process (BP) regulation of adaptive immune response based on somatic recombination of immune receptors built from 0.3552 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 0.1791 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) hydrolase activity 0.9191 Least Informative Inherited
Molecular Function (MF) structural molecule activity 0 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.000000023 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 0.7201 Moderately Informative Inherited
Molecular Function (MF) receptor activity 0 Informative Direct
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0 Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0 Informative Direct
Molecular Function (MF) sulfur compound binding 0 Informative Direct
Molecular Function (MF) phosphoric ester hydrolase activity 0 Informative Direct
Molecular Function (MF) protein dimerization activity 0.00000000000002611 Informative Direct
Molecular Function (MF) peptidase regulator activity 0.00001247 Informative Direct
Molecular Function (MF) amide binding 0.02973 Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 1 Informative Inherited
Molecular Function (MF) enzyme activator activity 0.01105 Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 1 Informative Inherited
Molecular Function (MF) receptor binding 0.8149 Informative Inherited
Molecular Function (MF) antigen binding 0 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0 Highly Informative Direct
Molecular Function (MF) heparin binding 0 Highly Informative Direct
Molecular Function (MF) phosphoprotein phosphatase activity 0 Highly Informative Direct
Molecular Function (MF) hormone binding 0.0000002851 Highly Informative Direct
Molecular Function (MF) peptide binding 0.00001742 Highly Informative Direct
Molecular Function (MF) protein homodimerization activity 0.0001997 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0.1399 Highly Informative Inherited
Molecular Function (MF) UDP-glycosyltransferase activity 0.0029 Highly Informative Inherited
Molecular Function (MF) transferase activity, transferring hexosyl groups 0.05437 Highly Informative Inherited
Molecular Function (MF) protein complex binding 0.3136 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.2275 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 0.0000000007795 Moderately Informative Direct
Cellular Component (CC) vesicle 0.02676 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 1 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.00683 Moderately Informative Inherited
Cellular Component (CC) neuron projection 0 Informative Direct
Cellular Component (CC) extracellular matrix 0 Informative Direct
Cellular Component (CC) contractile fiber part 0 Informative Direct
Cellular Component (CC) cell junction 0 Informative Direct
Cellular Component (CC) cell surface 0 Informative Direct
Cellular Component (CC) intrinsic to plasma membrane 0.000000000001165 Informative Direct
Cellular Component (CC) cell leading edge 0.000000006957 Informative Direct
Cellular Component (CC) extracellular membrane-bounded organelle 0.000001757 Informative Direct
Cellular Component (CC) endosome 0.000009661 Informative Direct
Cellular Component (CC) integral to membrane 0.0002422 Informative Direct
Cellular Component (CC) extracellular space 1 Informative Inherited
Cellular Component (CC) actin cytoskeleton 1 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) proteinaceous extracellular matrix 0 Highly Informative Direct
Cellular Component (CC) cell body 0 Highly Informative Direct
Cellular Component (CC) adherens junction 0 Highly Informative Direct
Cellular Component (CC) extracellular matrix part 0 Highly Informative Direct
Cellular Component (CC) integral to plasma membrane 0.0000000000009797 Highly Informative Direct
Cellular Component (CC) receptor complex 0.0000000006752 Highly Informative Direct
Cellular Component (CC) dendrite 0.0000003132 Highly Informative Direct
Cellular Component (CC) endosomal part 0.0001277 Highly Informative Direct
Cellular Component (CC) microtubule associated complex 0.0003316 Highly Informative Direct
Cellular Component (CC) main axon 0.0006964 Highly Informative Direct
Cellular Component (CC) sarcomere 0.02564 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0.000000000000007826Least InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl0.00000000004277Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.1816Moderately InformativeInherited
Enzyme Commission (EC)Receptor protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0InformativeDirect
Enzyme Commission (EC)Chitinase0.0002219Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.5371Least InformativeInherited
Disease Ontology (DO)urinary system disease0.2326Moderately InformativeInherited
Disease Ontology (DO)neurodegenerative disease0.4728Moderately InformativeInherited
Disease Ontology (DO)bacterial infectious disease0.528Moderately InformativeInherited
Disease Ontology (DO)kidney failure0.07244InformativeInherited
Disease Ontology (DO)primary bacterial infectious disease0.6852InformativeInherited
Disease Ontology (DO)acute kidney failure0.00001011Highly InformativeDirect
Disease Ontology (DO)leprosy0.03017Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of skeletal physiology0.1112Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.04475Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.3333Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.698Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.7957Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.8562Least InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.006574Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.01851Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development0.2262Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.2412Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.277Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.8788Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryogenesis/ development1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal circulating cytokine level0.00001202InformativeDirect
Mammalian Phenotype (MP)abnormal cell differentiation0.01458InformativeInherited
Mammalian Phenotype (MP)abnormal female genitalia morphology0.06112InformativeInherited
Mammalian Phenotype (MP)abnormal heart layer morphology0.1291InformativeInherited
Mammalian Phenotype (MP)abnormal extraembryonic tissue morphology0.1919InformativeInherited
Mammalian Phenotype (MP)abnormal interferon level0.3547InformativeInherited
Mammalian Phenotype (MP)abnormal spermatogenesis0.6246InformativeInherited
Mammalian Phenotype (MP)abnormal axon guidance0.0004633Highly InformativeDirect
Mammalian Phenotype (MP)abnormal vagina morphology0.04557Highly InformativeInherited
Mammalian Phenotype (MP)abnormal spermiogenesis0.05745Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.02119Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.0997Least InformativeInherited
Worm Phenotype (WP)growth variant0.7352Least InformativeInherited
Worm Phenotype (WP)organ system development variant0.0000003815Moderately InformativeDirect
Worm Phenotype (WP)cell homeostasis metabolism variant0.007356Moderately InformativeInherited
Worm Phenotype (WP)locomotion variant0.00995Moderately InformativeInherited
Worm Phenotype (WP)anchor cell invasion variant0.0000000001004InformativeDirect
Worm Phenotype (WP)neuron development variant0.0000005758InformativeDirect
Worm Phenotype (WP)cell migration variant0.0005568InformativeDirect
Worm Phenotype (WP)muscle cell morphology variant0.001963InformativeInherited
Worm Phenotype (WP)activity level variant0.01276InformativeInherited
Worm Phenotype (WP)locomotor coordination variant0.01636InformativeInherited
Worm Phenotype (WP)protein metabolism variant0.04595InformativeInherited
Worm Phenotype (WP)organism stress response variant0.647InformativeInherited
Worm Phenotype (WP)muscle arm development defective0.000000007638Highly InformativeDirect
Worm Phenotype (WP)axon morphology variant0.00000002387Highly InformativeDirect
Worm Phenotype (WP)myopodia present0.00000588Highly InformativeDirect
Worm Phenotype (WP)protein degradation variant0.0001454Highly InformativeDirect
Worm Phenotype (WP)roller0.0001569Highly InformativeDirect
Worm Phenotype (WP)growth rate variant0.0008138Highly InformativeDirect
Worm Phenotype (WP)loss of asymmetry ASE0.0009604Highly InformativeDirect
Worm Phenotype (WP)axon development variant0.5179Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)cell adhesion defective0.0001605Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system subdivision0.00002941Least InformativeDirect
Fly Anatomy (FA)anatomical group0.0001758Least InformativeDirect
Fly Anatomy (FA)organ system0.002866Least InformativeInherited
Fly Anatomy (FA)adult0.0147Least InformativeInherited
Fly Anatomy (FA)larva0.02104Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.03045Least InformativeInherited
Fly Anatomy (FA)cell0.3941Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.00000002802Moderately InformativeDirect
Fly Anatomy (FA)central nervous system0.02545Moderately InformativeInherited
Fly Anatomy (FA)late embryo0.02799Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.03067Moderately InformativeInherited
Fly Anatomy (FA)neuron0.0781Moderately InformativeInherited
Fly Anatomy (FA)adult nervous system0.09945Moderately InformativeInherited
Fly Anatomy (FA)sensillum0.1311Moderately InformativeInherited
Fly Anatomy (FA)adult segment0.2111Moderately InformativeInherited
Fly Anatomy (FA)adult head0.3585Moderately InformativeInherited
Fly Anatomy (FA)tagmatic subdivision of integument0.5231Moderately InformativeInherited
Fly Anatomy (FA)adult sense organ0.5867Moderately InformativeInherited
Fly Anatomy (FA)external sensory organ0.6555Moderately InformativeInherited
Fly Anatomy (FA)adult thorax0.7616Moderately InformativeInherited
Fly Anatomy (FA)appendage0.9009Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.9454Moderately InformativeInherited
Fly Anatomy (FA)thoracic segment1Moderately InformativeInherited
Fly Anatomy (FA)commissure0.0000002559InformativeDirect
Fly Anatomy (FA)adult brain0.002182InformativeInherited
Fly Anatomy (FA)chemosensory system0.00996InformativeInherited
Fly Anatomy (FA)chaeta0.05135InformativeInherited
Fly Anatomy (FA)supraesophageal ganglion0.0533InformativeInherited
Fly Anatomy (FA)sensory organ cell0.08003InformativeInherited
Fly Anatomy (FA)leg0.2971InformativeInherited
Fly Anatomy (FA)ipsilateral tract0.7351InformativeInherited
Fly Anatomy (FA)prothoracic leg taste bristle0.0004179Highly InformativeDirect
Fly Anatomy (FA)chemosensory neuron0.005286Highly InformativeInherited
Fly Anatomy (FA)eo neuron0.07905Highly InformativeInherited

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)central nervous system0.4368Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.4811Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)hindbrain0.000131InformativeDirect
Xenopus DEvelopment stage (XDE)NF stage0.00003228Least InformativeDirect
Xenopus DEvelopment stage (XDE)embryonic stage0.00003959Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases0.0000005017Least InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosylases0.00001951Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.1718Moderately InformativeInherited
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0Highly InformativeDirect
Enzyme Commission (EC)Chitinase0.0003967Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation0Moderately InformativeDirect
Biological processCarbohydrate metabolism0.176Moderately InformativeInherited
Biological processAngiogenesis0InformativeDirect
Biological processCell adhesion0InformativeDirect
Biological processEndocytosis0InformativeDirect
Biological processNeurogenesis0InformativeDirect
Biological processHemostasis0.0000026InformativeDirect
Biological processPolysaccharide degradation0.00011InformativeDirect
Biological processChemotaxis0.0003339InformativeDirect
Biological processAcute phase0.000000000001639Highly InformativeDirect
Biological processNotch signaling pathway0.00000001263Highly InformativeDirect
Biological processBlood coagulation0.000002469Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentCytoskeleton0.00000003492Moderately InformativeDirect
Cellular componentEndosome0.00005272Moderately InformativeDirect
Cellular componentExtracellular matrix0InformativeDirect
Cellular componentGPI-anchor0InformativeDirect
Coding sequence diversityAlternative splicing0.000005817Least InformativeDirect
DiseaseDisease mutation0.00001037Least InformativeDirect
DomainRepeat0Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
DomainImmunoglobulin domain0InformativeDirect
DomainEGF-like domain0.000000000000001223InformativeDirect
DomainLeucine-rich repeat0.000000000008177InformativeDirect
DomainCollagen0.000000005983Highly InformativeDirect
Molecular functionHeparin-binding0InformativeDirect
Molecular functionCalmodulin-binding0.000001864InformativeDirect
Molecular functionActin-binding0.00001413InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationProtease1Moderately InformativeInherited
Post-translational modificationProtein phosphatase0InformativeDirect
Post-translational modificationMetalloprotease0.0007179InformativeDirect
Post-translational modificationMuscle protein0Highly InformativeDirect
Post-translational modificationTyrosine-protein kinase0Highly InformativeDirect
Post-translational modificationCytokine0.000000000000001766Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationProteoglycan0.0008778InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism6.774e-16Least InformativeDirect
UniPathway (UP)protein glycosylation0.000000004649InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR008957 SSF49265 Protein matches
Abstract

Fibronectin is composed of three repeating structural motifs, of which one is the FnIII module. The three modules form a linear sequence of multiple tandem copies connected by short linker peptides. The secondary structure of the FnIII10 module, which is the only fibronectin module to possess an integrin binding RGD motif, consists of two beta-sheets containing the antiparallel beta-strands ABE and DCFG, respectively, which fold up to form a beta-sandwich. The RGD sequence is located in the loop connecting the beta-strands [PubMed9990027].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 111 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Fibronectin type III domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 111 hidden Markov models representing the Fibronectin type III superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]