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Fibronectin type III superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Immunoglobulin-like beta-sandwich [ 48725] (28)
Superfamily:   Fibronectin type III [ 49265]
Families:   Fibronectin type III [ 49266] (44)


Superfamily statistics
Genomes (1,734) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 70,299 209,622 172
Proteins 29,262 102,335 117


Functional annotation
General category Processes_EC
Detailed category Cell adhesion

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process0.00015950Least InformativeDirect
Biological Process (BP)single-organism cellular process0.040710Least InformativeInherited
Biological Process (BP)cell differentiation0.00061350.000000003567Moderately InformativeDirect
Biological Process (BP)locomotion0.000077430InformativeDirect
Biological Process (BP)movement of cell or subcellular component0.00080030InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0.000000000000687 Least Informative Direct
Biological Process (BP) macromolecule metabolic process 0.0000000001378 Least Informative Direct
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.369 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cell differentiation 0.000000003567 Moderately Informative Direct
Biological Process (BP) animal organ development 0.000000604 Moderately Informative Direct
Biological Process (BP) cell communication 0 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0 Moderately Informative Direct
Biological Process (BP) response to external stimulus 0 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0 Moderately Informative Direct
Biological Process (BP) single organism signaling 0 Moderately Informative Direct
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.0000000000009475 Moderately Informative Direct
Biological Process (BP) single-organism transport 0.00000000000398 Moderately Informative Direct
Biological Process (BP) defense response 0.00000002358 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.00000002898 Moderately Informative Direct
Biological Process (BP) response to biotic stimulus 0.00001052 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0.0009997 Moderately Informative Direct
Biological Process (BP) regulation of signaling 0.01286 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.05786 Moderately Informative Inherited
Biological Process (BP) protein complex biogenesis 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.7982 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.5282 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.1179 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.1542 Moderately Informative Inherited
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0 Informative Direct
Biological Process (BP) cell development 0 Informative Direct
Biological Process (BP) response to wounding 0 Informative Direct
Biological Process (BP) central nervous system development 0 Informative Direct
Biological Process (BP) vesicle-mediated transport 0 Informative Direct
Biological Process (BP) regulation of nervous system development 0 Informative Direct
Biological Process (BP) localization of cell 0 Informative Direct
Biological Process (BP) cell surface receptor signaling pathway 0 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0 Informative Direct
Biological Process (BP) cellular component morphogenesis 0 Informative Direct
Biological Process (BP) growth 0 Informative Direct
Biological Process (BP) regulation of cell differentiation 0 Informative Direct
Biological Process (BP) regulation of apoptotic process 0.0000000001958 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.00000001197 Informative Direct
Biological Process (BP) system process 0.0000001391 Informative Direct
Biological Process (BP) response to bacterium 0.0000004991 Informative Direct
Biological Process (BP) positive regulation of developmental process 0.0000009912 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.000001216 Informative Direct
Biological Process (BP) positive regulation of cellular protein metabolic process 0.00000159 Informative Direct
Biological Process (BP) regulation of locomotion 0.000001616 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.000005117 Informative Direct
Biological Process (BP) cell activation 0.00000554 Informative Direct
Biological Process (BP) actin cytoskeleton organization 0.00001248 Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.00001291 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0.00002886 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.00006218 Informative Direct
Biological Process (BP) regulation of response to external stimulus 0.00007614 Informative Direct
Biological Process (BP) regulation of protein modification process 0.0001792 Informative Direct
Biological Process (BP) generation of neurons 0.0001878 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.0004359 Informative Direct
Biological Process (BP) phosphorylation 0.0006591 Informative Direct
Biological Process (BP) regulation of phosphorylation 0.0008375 Informative Direct
Biological Process (BP) regulation of growth 0.0008717 Informative Direct
Biological Process (BP) negative regulation of signaling 0.0009708 Informative Direct
Biological Process (BP) regulation of intracellular signal transduction 0.4463 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.8478 Informative Inherited
Biological Process (BP) response to nitrogen compound 1 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.9984 Informative Inherited
Biological Process (BP) negative regulation of cell death 0.02024 Informative Inherited
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) metal ion transport 1 Informative Inherited
Biological Process (BP) inorganic ion homeostasis 1 Informative Inherited
Biological Process (BP) single-organism membrane organization 1 Informative Inherited
Biological Process (BP) supramolecular fiber organization 0.01428 Informative Inherited
Biological Process (BP) organelle assembly 0.1028 Informative Inherited
Biological Process (BP) cellular protein complex assembly 0.3255 Informative Inherited
Biological Process (BP) regulation of proteolysis 0.3915 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.005254 Informative Inherited
Biological Process (BP) defense response to other organism 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 1 Informative Inherited
Biological Process (BP) regulation of transferase activity 0.9309 Informative Inherited
Biological Process (BP) negative regulation of cellular protein metabolic process 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.004507 Informative Inherited
Biological Process (BP) cell cycle process 1 Informative Inherited
Biological Process (BP) organelle localization 0.9299 Informative Inherited
Biological Process (BP) protein oligomerization 0.6929 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 1 Informative Inherited
Biological Process (BP) transmembrane transport 1 Informative Inherited
Biological Process (BP) cation homeostasis 1 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.564 Informative Inherited
Biological Process (BP) negative regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.7704 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 1 Informative Inherited
Biological Process (BP) multicellular organism reproduction 1 Informative Inherited
Biological Process (BP) mitotic cell cycle 1 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) pigment metabolic process 0.0244 Informative Inherited
Biological Process (BP) regulation of defense response 1 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.001783 Informative Inherited
Biological Process (BP) regulation of cytokine production 1 Informative Inherited
Biological Process (BP) response to extracellular stimulus 1 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.9908 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 0.004159 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.284 Informative Inherited
Biological Process (BP) multi-organism reproductive process 1 Informative Inherited
Biological Process (BP) glycerolipid metabolic process 0.7988 Informative Inherited
Biological Process (BP) secondary metabolic process 0.3567 Informative Inherited
Biological Process (BP) negative regulation of molecular function 1 Informative Inherited
Biological Process (BP) circulatory system development 0.9461 Informative Inherited
Biological Process (BP) embryo development 1 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) regulation of immune response 0.7299 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.2415 Informative Inherited
Biological Process (BP) proteolysis 1 Informative Inherited
Biological Process (BP) immune response 0.2602 Informative Inherited
Biological Process (BP) hemopoiesis 0.2202 Informative Inherited
Biological Process (BP) immune effector process 0.06079 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) reproductive system development 1 Informative Inherited
Biological Process (BP) microtubule-based process 1 Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0 Highly Informative Direct
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0 Highly Informative Direct
Biological Process (BP) positive regulation of cell adhesion 0 Highly Informative Direct
Biological Process (BP) cell growth 0 Highly Informative Direct
Biological Process (BP) plasma membrane bounded cell projection organization 0 Highly Informative Direct
Biological Process (BP) protein dephosphorylation 0 Highly Informative Direct
Biological Process (BP) biological adhesion 0 Highly Informative Direct
Biological Process (BP) neuron development 0 Highly Informative Direct
Biological Process (BP) developmental growth involved in morphogenesis 0 Highly Informative Direct
Biological Process (BP) response to mechanical stimulus 0 Highly Informative Direct
Biological Process (BP) phagocytosis 0 Highly Informative Direct
Biological Process (BP) response to molecule of bacterial origin 0 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0 Highly Informative Direct
Biological Process (BP) regulation of neuron projection development 0 Highly Informative Direct
Biological Process (BP) negative regulation of response to external stimulus 0.0000000001662 Highly Informative Direct
Biological Process (BP) regulation of response to wounding 0.0000000004631 Highly Informative Direct
Biological Process (BP) regulation of cell size 0.000000001282 Highly Informative Direct
Biological Process (BP) negative regulation of locomotion 0.000000002718 Highly Informative Direct
Biological Process (BP) positive regulation of cellular component biogenesis 0.00000001789 Highly Informative Direct
Biological Process (BP) regulation of toll-like receptor signaling pathway 0.00000007137 Highly Informative Direct
Biological Process (BP) negative regulation of cellular component movement 0.00000008857 Highly Informative Direct
Biological Process (BP) sex differentiation 0.00000009201 Highly Informative Direct
Biological Process (BP) sensory organ morphogenesis 0.00000009856 Highly Informative Direct
Biological Process (BP) cellular component assembly involved in morphogenesis 0.00000128 Highly Informative Direct
Biological Process (BP) positive regulation of protein kinase B signaling 0.000001548 Highly Informative Direct
Biological Process (BP) lymphocyte activation 0.000005282 Highly Informative Direct
Biological Process (BP) negative regulation of growth 0.000006416 Highly Informative Direct
Biological Process (BP) response to axon injury 0.00001179 Highly Informative Direct
Biological Process (BP) regulation of neuron apoptotic process 0.00001905 Highly Informative Direct
Biological Process (BP) coagulation 0.00003087 Highly Informative Direct
Biological Process (BP) regeneration 0.00003432 Highly Informative Direct
Biological Process (BP) actomyosin structure organization 0.00004175 Highly Informative Direct
Biological Process (BP) spermatogenesis 0.00005263 Highly Informative Direct
Biological Process (BP) positive regulation of leukocyte proliferation 0.0000589 Highly Informative Direct
Biological Process (BP) forebrain development 0.00006156 Highly Informative Direct
Biological Process (BP) negative regulation of immune system process 0.0001192 Highly Informative Direct
Biological Process (BP) regulation of leukocyte mediated immunity 0.0001328 Highly Informative Direct
Biological Process (BP) cytokine-mediated signaling pathway 0.0001505 Highly Informative Direct
Biological Process (BP) regulation of blood pressure 0.0003081 Highly Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.0004675 Highly Informative Direct
Biological Process (BP) positive regulation of growth 0.0005471 Highly Informative Direct
Biological Process (BP) positive regulation of nervous system development 0.0007211 Highly Informative Direct
Biological Process (BP) anatomical structure homeostasis 0.0008161 Highly Informative Direct
Biological Process (BP) regulation of GTPase activity 0.001833 Highly Informative Inherited
Biological Process (BP) regulation of binding 0.04915 Highly Informative Inherited
Biological Process (BP) regulation of reproductive process 1 Highly Informative Inherited
Biological Process (BP) regulation of hemopoiesis 1 Highly Informative Inherited
Biological Process (BP) cellular response to organonitrogen compound 0.266 Highly Informative Inherited
Biological Process (BP) inorganic cation transmembrane transport 0.5181 Highly Informative Inherited
Biological Process (BP) leukocyte migration 0.3888 Highly Informative Inherited
Biological Process (BP) multicellular organismal homeostasis 1 Highly Informative Inherited
Biological Process (BP) kidney development 0.4281 Highly Informative Inherited
Biological Process (BP) response to growth factor 1 Highly Informative Inherited
Biological Process (BP) actin filament organization 0.8823 Highly Informative Inherited
Biological Process (BP) striated muscle cell development 0.5137 Highly Informative Inherited
Biological Process (BP) cell proliferation 0.1379 Highly Informative Inherited
Biological Process (BP) positive regulation of cell development 1 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.02152 Highly Informative Inherited
Biological Process (BP) hemostasis 0.06016 Highly Informative Inherited
Biological Process (BP) epithelial cell differentiation 1 Highly Informative Inherited
Biological Process (BP) camera-type eye development 0.1385 Highly Informative Inherited
Biological Process (BP) heart development 0.2129 Highly Informative Inherited
Biological Process (BP) response to virus 0.2779 Highly Informative Inherited
Biological Process (BP) positive regulation of supramolecular fiber organization 0.3234 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 1 Highly Informative Inherited
Biological Process (BP) negative regulation of phosphate metabolic process 0.8219 Highly Informative Inherited
Biological Process (BP) regulation of MAP kinase activity 0.3267 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular signal transduction 1 Highly Informative Inherited
Biological Process (BP) cellular calcium ion homeostasis 0.4347 Highly Informative Inherited
Biological Process (BP) divalent inorganic cation transport 0.5181 Highly Informative Inherited
Biological Process (BP) negative regulation of homeostatic process 0.2724 Highly Informative Inherited
Biological Process (BP) regulation of ion homeostasis 0.4689 Highly Informative Inherited
Biological Process (BP) nervous system process 0.004705 Highly Informative Inherited
Biological Process (BP) immune response-activating signal transduction 0.06125 Highly Informative Inherited
Biological Process (BP) glycosaminoglycan metabolic process 1 Highly Informative Inherited
Biological Process (BP) positive regulation of response to external stimulus 0.01164 Highly Informative Inherited
Biological Process (BP) negative regulation of cell development 0.9261 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.06397 Highly Informative Inherited
Biological Process (BP) positive regulation of lipid metabolic process 0.008816 Highly Informative Inherited
Biological Process (BP) regulation of cellular ketone metabolic process 0.6579 Highly Informative Inherited
Biological Process (BP) negative regulation of defense response 0.001674 Highly Informative Inherited
Biological Process (BP) negative regulation of lipid metabolic process 0.06591 Highly Informative Inherited
Biological Process (BP) response to alcohol 1 Highly Informative Inherited
Biological Process (BP) regulation of circadian rhythm 0.7934 Highly Informative Inherited
Biological Process (BP) anatomical structure maturation 0.3779 Highly Informative Inherited
Biological Process (BP) cell maturation 1 Highly Informative Inherited
Biological Process (BP) negative regulation of apoptotic process 0.1495 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 0.7568 Highly Informative Inherited
Biological Process (BP) regulation of cysteine-type endopeptidase activity 0.9003 Highly Informative Inherited
Biological Process (BP) positive regulation of apoptotic process 0.9623 Highly Informative Inherited
Biological Process (BP) activation of protein kinase activity 0.7989 Highly Informative Inherited
Biological Process (BP) microtubule cytoskeleton organization 1 Highly Informative Inherited
Biological Process (BP) macromolecule glycosylation 0.6957 Highly Informative Inherited
Biological Process (BP) innate immune response 0.1638 Highly Informative Inherited
Biological Process (BP) phenol-containing compound metabolic process 0.005541 Highly Informative Inherited
Biological Process (BP) multicellular organism metabolic process 0.02196 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 1 Highly Informative Inherited
Biological Process (BP) response to nutrient levels 0.8709 Highly Informative Inherited
Biological Process (BP) regulation of cell killing 0.003955 Highly Informative Inherited
Biological Process (BP) negative regulation of nervous system development 0.5023 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.1061 Highly Informative Inherited
Biological Process (BP) regulation of cell growth 0.01967 Highly Informative Inherited
Biological Process (BP) glycoprotein metabolic process 0.01909 Highly Informative Inherited
Biological Process (BP) wound healing 0.9754 Highly Informative Inherited
Biological Process (BP) cell projection assembly 1 Highly Informative Inherited
Biological Process (BP) regulation of lipid localization 0.8489 Highly Informative Inherited
Biological Process (BP) regulation of epithelial cell migration 0.1871 Highly Informative Inherited
Biological Process (BP) cell-cell signaling 1 Highly Informative Inherited
Biological Process (BP) muscle system process 1 Highly Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.01677 Highly Informative Inherited
Biological Process (BP) positive regulation of proteolysis 0.006493 Highly Informative Inherited
Biological Process (BP) acylglycerol metabolic process 0.00511 Highly Informative Inherited
Biological Process (BP) protein lipidation 0.5603 Highly Informative Inherited
Biological Process (BP) post-translational protein modification 0.8379 Highly Informative Inherited
Biological Process (BP) negative regulation of transferase activity 0.002602 Highly Informative Inherited
Biological Process (BP) negative regulation of protein modification process 0.5224 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 1 Highly Informative Inherited
Biological Process (BP) muscle tissue development 0.002745 Highly Informative Inherited
Biological Process (BP) embryonic organ development 1 Highly Informative Inherited
Biological Process (BP) tube morphogenesis 1 Highly Informative Inherited
Biological Process (BP) positive regulation of adaptive immune response based on somatic recombination of immune receptors b 1 Highly Informative Inherited
Biological Process (BP) cell chemotaxis 0.004611 Highly Informative Inherited
Biological Process (BP) protein maturation 0.0117 Highly Informative Inherited
Biological Process (BP) inflammatory response 0.01976 Highly Informative Inherited
Biological Process (BP) leukocyte differentiation 0.5848 Highly Informative Inherited
Biological Process (BP) angiogenesis 0.02906 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 0.492 Highly Informative Inherited
Biological Process (BP) regulation of epithelial cell proliferation 0.02605 Highly Informative Inherited
Biological Process (BP) myeloid cell homeostasis 0.6899 Highly Informative Inherited
Biological Process (BP) establishment of organelle localization 0.9133 Highly Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 0.004926 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) transferase activity 0.0000009851 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) structural molecule activity 0.000000000000006264 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 0.00000000009775 Moderately Informative Direct
Molecular Function (MF) anion binding 0.0005419 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.2442 Moderately Informative Inherited
Molecular Function (MF) molecular function regulator 0.9788 Moderately Informative Inherited
Molecular Function (MF) phosphatase activity 0 Informative Direct
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) sulfur compound binding 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0 Informative Direct
Molecular Function (MF) signal transducer activity 0 Informative Direct
Molecular Function (MF) identical protein binding 0 Informative Direct
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) protein dimerization activity 0.00000000000003442 Informative Direct
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) peptidase regulator activity 0.3438 Informative Inherited
Molecular Function (MF) enzyme inhibitor activity 0.9262 Informative Inherited
Molecular Function (MF) amide binding 0.009365 Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 1 Informative Inherited
Molecular Function (MF) enzyme binding 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 1 Informative Inherited
Molecular Function (MF) macromolecular complex binding 0.03094 Informative Inherited
Molecular Function (MF) transmembrane signaling receptor activity 0 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0 Highly Informative Direct
Molecular Function (MF) phosphoprotein phosphatase activity 0 Highly Informative Direct
Molecular Function (MF) heparin binding 0 Highly Informative Direct
Molecular Function (MF) cell adhesion molecule binding 0.000000000002754 Highly Informative Direct
Molecular Function (MF) hormone binding 0.000000004147 Highly Informative Direct
Molecular Function (MF) protein homodimerization activity 0.000000534 Highly Informative Direct
Molecular Function (MF) peptide binding 0.000001078 Highly Informative Direct
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0.00009864 Highly Informative Direct
Molecular Function (MF) kinase binding 0.0002632 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0.1181 Highly Informative Inherited
Molecular Function (MF) cysteine-type endopeptidase regulator activity involved in apoptotic process 0.003835 Highly Informative Inherited
Molecular Function (MF) cysteine-type endopeptidase inhibitor activity 0.00891 Highly Informative Inherited
Molecular Function (MF) UDP-glycosyltransferase activity 0.03067 Highly Informative Inherited
Molecular Function (MF) transferase activity, transferring hexosyl groups 0.2508 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intrinsic component of membrane 0 Moderately Informative Direct
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) vesicle 0.0002514 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.7942 Moderately Informative Inherited
Cellular Component (CC) whole membrane 1 Moderately Informative Inherited
Cellular Component (CC) bounding membrane of organelle 1 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 0.9535 Moderately Informative Inherited
Cellular Component (CC) neuron projection 0 Informative Direct
Cellular Component (CC) cell surface 0 Informative Direct
Cellular Component (CC) apical part of cell 0.00000001533 Informative Direct
Cellular Component (CC) extracellular organelle 0.00005407 Informative Direct
Cellular Component (CC) endosome 0.0009088 Informative Direct
Cellular Component (CC) supramolecular polymer 0.8846 Informative Inherited
Cellular Component (CC) cytoplasmic region 0.5616 Informative Inherited
Cellular Component (CC) plasma membrane bounded cell projection part 1 Informative Inherited
Cellular Component (CC) extracellular space 1 Informative Inherited
Cellular Component (CC) cytoplasmic vesicle part 0.01007 Informative Inherited
Cellular Component (CC) actin cytoskeleton 1 Informative Inherited
Cellular Component (CC) plasma membrane region 0.4654 Informative Inherited
Cellular Component (CC) intrinsic component of plasma membrane 0 Highly Informative Direct
Cellular Component (CC) neuronal cell body 0.0000000000003026 Highly Informative Direct
Cellular Component (CC) dendrite 0.00000000003655 Highly Informative Direct
Cellular Component (CC) receptor complex 0.0000006876 Highly Informative Direct
Cellular Component (CC) apical plasma membrane 0.000001346 Highly Informative Direct
Cellular Component (CC) extracellular matrix component 0.00001942 Highly Informative Direct
Cellular Component (CC) sarcomere 0.00008744 Highly Informative Direct
Cellular Component (CC) presynapse 1 Highly Informative Inherited
Cellular Component (CC) cortical cytoskeleton 0.07258 Highly Informative Inherited
Cellular Component (CC) growth cone 0.03167 Highly Informative Inherited
Cellular Component (CC) endosome membrane 0.003849 Highly Informative Inherited
Cellular Component (CC) cell-substrate adherens junction 1 Highly Informative Inherited
Cellular Component (CC) cell-cell junction 0.2778 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0.000000000000007826Least InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl0.00000000004277Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.1816Moderately InformativeInherited
Enzyme Commission (EC)Receptor protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0InformativeDirect
Enzyme Commission (EC)Chitinase0.0002219Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation0Moderately InformativeDirect
Biological processCarbohydrate metabolism0.1727Moderately InformativeInherited
Biological processAngiogenesis0InformativeDirect
Biological processCell adhesion0InformativeDirect
Biological processEndocytosis0InformativeDirect
Biological processNeurogenesis0InformativeDirect
Biological processHemostasis0.000003016InformativeDirect
Biological processPolysaccharide degradation0.0000579InformativeDirect
Biological processChemotaxis0.0005199InformativeDirect
Biological processSensory transduction0.04012InformativeInherited
Biological processAcute phase0.000000000001977Highly InformativeDirect
Biological processNotch signaling pathway0.00000001528Highly InformativeDirect
Biological processBlood coagulation0.000002864Highly InformativeDirect
Biological processVision0.00003342Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentEndosome0.000000004685Moderately InformativeDirect
Cellular componentCytoskeleton0.0000003916Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.0006831Moderately InformativeDirect
Cellular componentExtracellular matrix0InformativeDirect
Cellular componentGPI-anchor0InformativeDirect
Coding sequence diversityAlternative splicing0.000005264Least InformativeDirect
DiseaseDisease mutation0.000009924Least InformativeDirect
DomainRepeat0Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
DomainImmunoglobulin domain0InformativeDirect
DomainEGF-like domain0.00000000000000246InformativeDirect
DomainLeucine-rich repeat0.00000000000001837InformativeDirect
DomainCollagen0.000000006427Highly InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationHeparin-binding0InformativeDirect
Post-translational modificationProtein phosphatase0InformativeDirect
Post-translational modificationCalmodulin-binding0.000003234InformativeDirect
Post-translational modificationActin-binding0.00002071InformativeDirect
Post-translational modificationGlycosidase0.0002555InformativeDirect
Post-translational modificationMuscle protein0Highly InformativeDirect
Post-translational modificationTyrosine-protein kinase0Highly InformativeDirect
Post-translational modificationCytokine0.00000000000000305Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationProteoglycan0.000002788InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR008957 SSF49265 Protein matches
Abstract

Fibronectin is composed of three repeating structural motifs, of which one is the FnIII module. The three modules form a linear sequence of multiple tandem copies connected by short linker peptides. The secondary structure of the FnIII10 module, which is the only fibronectin module to possess an integrin binding RGD motif, consists of two beta-sheets containing the antiparallel beta-strands ABE and DCFG, respectively, which fold up to form a beta-sandwich. The RGD sequence is located in the loop connecting the beta-strands [PubMed9990027].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 111 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Fibronectin type III domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 111 hidden Markov models representing the Fibronectin type III superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]