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Fibronectin type III superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Immunoglobulin-like beta-sandwich [ 48725] (28)
Superfamily:   Fibronectin type III [ 49265]
Families:   Fibronectin type III [ 49266] (44)


Superfamily statistics
Genomes (1,736) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 71,149 265,201 172
Proteins 29,622 129,837 117


Functional annotation
General category Processes_EC
Detailed category Cell adhesion

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0.000000000000007826Least InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl0.00000000004277Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.1816Moderately InformativeInherited
Enzyme Commission (EC)Receptor protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0InformativeDirect
Enzyme Commission (EC)Chitinase0.0002219Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.5337Least InformativeInherited
Disease Ontology (DO)urinary system disease0.235Moderately InformativeInherited
Disease Ontology (DO)neurodegenerative disease0.4836Moderately InformativeInherited
Disease Ontology (DO)disease by infectious agent0.5738Moderately InformativeInherited
Disease Ontology (DO)primary bacterial infectious disease0.7038InformativeInherited
Disease Ontology (DO)acute kidney failure0.000001623Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.007497Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.2368Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.6371Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.6549Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.9234Least InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.004713Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.02556Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.1204Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development0.1595Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.2398Moderately InformativeInherited
Mammalian Phenotype (MP)reproductive system phenotype0.531Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.8025Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal circulating cytokine level0.000002403InformativeDirect
Mammalian Phenotype (MP)autoimmune response0.0001171InformativeDirect
Mammalian Phenotype (MP)abnormal cell differentiation0.002711InformativeInherited
Mammalian Phenotype (MP)abnormal heart layer morphology0.1193InformativeInherited
Mammalian Phenotype (MP)abnormal female reproductive system physiology0.2129InformativeInherited
Mammalian Phenotype (MP)abnormal white adipose tissue morphology0.3795InformativeInherited
Mammalian Phenotype (MP)abnormal interferon level0.4774InformativeInherited
Mammalian Phenotype (MP)abnormal spermatogenesis0.6091InformativeInherited
Mammalian Phenotype (MP)increased apoptosis0.806InformativeInherited
Mammalian Phenotype (MP)abnormal adipose tissue amount0.8313InformativeInherited
Mammalian Phenotype (MP)abnormal axon guidance0.0004411Highly InformativeDirect
Mammalian Phenotype (MP)abnormal spermiogenesis0.08925Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell morphology variant0.00004176Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.0003487Least InformativeDirect
Worm Phenotype (WP)cell development variant0.001306Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.007697Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.04012Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.1945Least InformativeInherited
Worm Phenotype (WP)nervous system morphology variant0.001644Moderately InformativeInherited
Worm Phenotype (WP)metabolic pathway variant0.001888Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.01079Moderately InformativeInherited
Worm Phenotype (WP)reproductive system development variant0.02667Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.04468Moderately InformativeInherited
Worm Phenotype (WP)cell component morphology variant0.9902Moderately InformativeInherited
Worm Phenotype (WP)protein degradation variant0.000004884InformativeDirect
Worm Phenotype (WP)locomotion reduced0.00000511InformativeDirect
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.00005735InformativeDirect
Worm Phenotype (WP)body posture variant0.0002837InformativeDirect
Worm Phenotype (WP)mitochondria morphology variant0.0003203InformativeDirect
Worm Phenotype (WP)locomotor coordination variant0.001996InformativeInherited
Worm Phenotype (WP)muscle cell physiology variant0.004628InformativeInherited
Worm Phenotype (WP)neuronal outgrowth variant0.008597InformativeInherited
Worm Phenotype (WP)forward locomotion variant0.02588InformativeInherited
Worm Phenotype (WP)anchor cell invasion variant0.00000000003558Highly InformativeDirect
Worm Phenotype (WP)muscle arm development defective0.000000005158Highly InformativeDirect
Worm Phenotype (WP)forward locomotion decreased0.00004132Highly InformativeDirect
Worm Phenotype (WP)loss of left right asymmetry0.09581Highly InformativeInherited
Worm Phenotype (WP)axon development variant0.1949Highly InformativeInherited
Worm Phenotype (WP)neuronal cell fate specification variant0.1959Highly InformativeInherited
Worm Phenotype (WP)path curvature variant0.7274Highly InformativeInherited
Worm Phenotype (WP)axon morphology variant0.7754Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system subdivision0.0002834Least InformativeDirect
Fly Anatomy (FA)anatomical group0.001563Least InformativeInherited
Fly Anatomy (FA)embryo0.02035Least InformativeInherited
Fly Anatomy (FA)nervous system0.02917Least InformativeInherited
Fly Anatomy (FA)larva0.0348Least InformativeInherited
Fly Anatomy (FA)adult0.1158Least InformativeInherited
Fly Anatomy (FA)somatic cell0.3336Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.00000001637Moderately InformativeDirect
Fly Anatomy (FA)central nervous system0.01456Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.03117Moderately InformativeInherited
Fly Anatomy (FA)late embryo0.06391Moderately InformativeInherited
Fly Anatomy (FA)cell cluster organ0.1071Moderately InformativeInherited
Fly Anatomy (FA)sense organ0.1827Moderately InformativeInherited
Fly Anatomy (FA)adult segment0.1907Moderately InformativeInherited
Fly Anatomy (FA)neuron0.2681Moderately InformativeInherited
Fly Anatomy (FA)adult thorax0.727Moderately InformativeInherited
Fly Anatomy (FA)appendage0.939Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.9663Moderately InformativeInherited
Fly Anatomy (FA)thoracic segment1Moderately InformativeInherited
Fly Anatomy (FA)tagmatic subdivision of integument1Moderately InformativeInherited
Fly Anatomy (FA)larval abdomen0.0000004301InformativeDirect
Fly Anatomy (FA)synaptic neuropil0.0001169InformativeDirect
Fly Anatomy (FA)nerve0.0005422InformativeDirect
Fly Anatomy (FA)chemosensory system0.02899InformativeInherited
Fly Anatomy (FA)chaeta0.09016InformativeInherited
Fly Anatomy (FA)leg0.3017InformativeInherited
Fly Anatomy (FA)tract0.4188InformativeInherited
Fly Anatomy (FA)prothoracic leg taste bristle chemosensory neuron0.00001142Highly InformativeDirect
Fly Anatomy (FA)commissure0.00002023Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)compound organ0.06079Least InformativeInherited
Zebrafish Anatomy (ZA)multi-tissue structure0.1126Least InformativeInherited
Zebrafish Anatomy (ZA)nervous system0.612Least InformativeInherited
Zebrafish Anatomy (ZA)central nervous system0.2314Moderately InformativeInherited
Zebrafish Anatomy (ZA)brain0.4253InformativeInherited
Zebrafish Anatomy (ZA)medial longitudinal fasciculus0.00002284Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system0.6645Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.9324Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.985Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue1Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.06516Moderately InformativeInherited
Xenopus ANatomical entity (XAN)sensory system0.3284Moderately InformativeInherited
Xenopus ANatomical entity (XAN)eye0.5654InformativeInherited
Xenopus ANatomical entity (XAN)retinal ganglion cell layer0.0006356Highly InformativeDirect
Xenopus DEvelopment stage (XDE)embryonic stage0.00001736Moderately InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases0.00001016Least InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosylases0.00002173Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.1236Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases0.7677Moderately InformativeInherited
Enzyme Commission (EC)Acyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0InformativeDirect
Enzyme Commission (EC)RING-type E3 ubiquitin transferase0.0000000005483InformativeDirect
Enzyme Commission (EC)Hexosyltransferases0.0000159InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0Highly InformativeDirect
Enzyme Commission (EC)Chitinase0.0005545Highly InformativeDirect

Document: EC annotation of SCOP domains

InterPro annotation
Cross references IPR008957 SSF49265 Protein matches
Abstract

Fibronectin is composed of three repeating structural motifs, of which one is the FnIII module. The three modules form a linear sequence of multiple tandem copies connected by short linker peptides. The secondary structure of the FnIII10 module, which is the only fibronectin module to possess an integrin binding RGD motif, consists of two beta-sheets containing the antiparallel beta-strands ABE and DCFG, respectively, which fold up to form a beta-sandwich. The RGD sequence is located in the loop connecting the beta-strands [PubMed9990027].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 111 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Fibronectin type III domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 111 hidden Markov models representing the Fibronectin type III superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]