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Fibronectin type III superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Immunoglobulin-like beta-sandwich [ 48725] (28)
Superfamily:   Fibronectin type III [ 49265]
Families:   Fibronectin type III [ 49266] (44)


Superfamily statistics
Genomes (1,734) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 70,299 209,622 172
Proteins 29,262 102,335 117


Functional annotation
General category Processes_EC
Detailed category Cell adhesion

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism cellular process0.041540Least InformativeInherited
Biological Process (BP)system development0.00020820Moderately InformativeDirect
Biological Process (BP)cellular developmental process0.013630Moderately InformativeInherited
Biological Process (BP)locomotion0.000067160InformativeDirect
Biological Process (BP)movement of cell or subcellular component0.00065320InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0 Least Informative Direct
Biological Process (BP) macromolecule metabolic process 0.00000000000009312 Least Informative Direct
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.05469 Least Informative Inherited
Biological Process (BP) system development 0 Moderately Informative Direct
Biological Process (BP) cellular developmental process 0 Moderately Informative Direct
Biological Process (BP) single organism signaling 0 Moderately Informative Direct
Biological Process (BP) response to external stimulus 0 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0 Moderately Informative Direct
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) cell communication 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.0000000005797 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.0000000008429 Moderately Informative Direct
Biological Process (BP) single-organism transport 0.00000001647 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0.00004753 Moderately Informative Direct
Biological Process (BP) regulation of signaling 0.0004341 Moderately Informative Direct
Biological Process (BP) cellular component assembly 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.4117 Moderately Informative Inherited
Biological Process (BP) response to biotic stimulus 0.003042 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.05341 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.003892 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) protein complex biogenesis 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.5069 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.04668 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0 Informative Direct
Biological Process (BP) cell development 0 Informative Direct
Biological Process (BP) growth 0 Informative Direct
Biological Process (BP) cellular component morphogenesis 0 Informative Direct
Biological Process (BP) regulation of cell differentiation 0 Informative Direct
Biological Process (BP) regulation of nervous system development 0 Informative Direct
Biological Process (BP) cell surface receptor signaling pathway 0 Informative Direct
Biological Process (BP) dephosphorylation 0 Informative Direct
Biological Process (BP) central nervous system development 0 Informative Direct
Biological Process (BP) vesicle-mediated transport 0 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.000000000000003764 Informative Direct
Biological Process (BP) regulation of apoptotic process 0.00000000001294 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.00000001787 Informative Direct
Biological Process (BP) regulation of locomotion 0.0000001652 Informative Direct
Biological Process (BP) positive regulation of developmental process 0.0000001674 Informative Direct
Biological Process (BP) positive regulation of cellular protein metabolic process 0.0000002997 Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.000000347 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.0000007798 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.000005076 Informative Direct
Biological Process (BP) cytoskeleton organization 0.000008768 Informative Direct
Biological Process (BP) cell activation 0.000008853 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0.00002702 Informative Direct
Biological Process (BP) system process 0.00002753 Informative Direct
Biological Process (BP) response to bacterium 0.00003334 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.00007162 Informative Direct
Biological Process (BP) regulation of response to external stimulus 0.00007284 Informative Direct
Biological Process (BP) response to cytokine 0.00007434 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.00008442 Informative Direct
Biological Process (BP) regulation of growth 0.00022 Informative Direct
Biological Process (BP) regulation of cell proliferation 0.0003132 Informative Direct
Biological Process (BP) regulation of protein modification process 0.0006097 Informative Direct
Biological Process (BP) negative regulation of signaling 0.0009531 Informative Direct
Biological Process (BP) positive regulation of catalytic activity 0.4917 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.9502 Informative Inherited
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) ion homeostasis 1 Informative Inherited
Biological Process (BP) transmembrane transport 1 Informative Inherited
Biological Process (BP) membrane organization 1 Informative Inherited
Biological Process (BP) embryo development 1 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.1944 Informative Inherited
Biological Process (BP) sensory organ development 0.06083 Informative Inherited
Biological Process (BP) defense response to other organism 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 1 Informative Inherited
Biological Process (BP) protein oligomerization 0.691 Informative Inherited
Biological Process (BP) metal ion transport 1 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 1 Informative Inherited
Biological Process (BP) positive regulation of immune response 1 Informative Inherited
Biological Process (BP) generation of neurons 0.001272 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.7459 Informative Inherited
Biological Process (BP) cell-cell signaling 1 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.436 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.003757 Informative Inherited
Biological Process (BP) negative regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) organelle assembly 0.08838 Informative Inherited
Biological Process (BP) negative regulation of cell death 0.02493 Informative Inherited
Biological Process (BP) response to nitrogen compound 1 Informative Inherited
Biological Process (BP) regulation of proteolysis 0.4225 Informative Inherited
Biological Process (BP) positive regulation of cell death 0.7343 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) regulation of transferase activity 1 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 1 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.3965 Informative Inherited
Biological Process (BP) pigment metabolic process 0.01363 Informative Inherited
Biological Process (BP) immune effector process 0.02911 Informative Inherited
Biological Process (BP) secondary metabolic process 0.2641 Informative Inherited
Biological Process (BP) regulation of defense response 1 Informative Inherited
Biological Process (BP) regulation of cytokine production 1 Informative Inherited
Biological Process (BP) response to extracellular stimulus 1 Informative Inherited
Biological Process (BP) cellular protein complex assembly 0.1959 Informative Inherited
Biological Process (BP) supramolecular fiber organization 0.005928 Informative Inherited
Biological Process (BP) actin filament-based process 0.01678 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.904 Informative Inherited
Biological Process (BP) phosphorylation 0.001098 Informative Inherited
Biological Process (BP) proteolysis 1 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) multicellular organism reproduction 1 Informative Inherited
Biological Process (BP) multi-organism reproductive process 1 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 0.002222 Informative Inherited
Biological Process (BP) glycerolipid metabolic process 0.6802 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 1 Informative Inherited
Biological Process (BP) negative regulation of molecular function 1 Informative Inherited
Biological Process (BP) circulatory system development 0.8083 Informative Inherited
Biological Process (BP) immune response 0.1242 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.004985 Informative Inherited
Biological Process (BP) regulation of phosphorylation 0.001174 Informative Inherited
Biological Process (BP) tissue development 1 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) reproductive system development 1 Informative Inherited
Biological Process (BP) microtubule-based process 1 Informative Inherited
Biological Process (BP) cell cycle process 1 Informative Inherited
Biological Process (BP) mitotic cell cycle 1 Informative Inherited
Biological Process (BP) organelle localization 1 Informative Inherited
Biological Process (BP) response to mechanical stimulus 0 Highly Informative Direct
Biological Process (BP) brain development 0 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 0 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0 Highly Informative Direct
Biological Process (BP) positive regulation of cell adhesion 0 Highly Informative Direct
Biological Process (BP) biological adhesion 0 Highly Informative Direct
Biological Process (BP) regulation of neuron projection development 0 Highly Informative Direct
Biological Process (BP) plasma membrane bounded cell projection organization 0 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0 Highly Informative Direct
Biological Process (BP) chemotaxis 0 Highly Informative Direct
Biological Process (BP) cell growth 0 Highly Informative Direct
Biological Process (BP) phagocytosis 0 Highly Informative Direct
Biological Process (BP) protein dephosphorylation 0 Highly Informative Direct
Biological Process (BP) neuron development 0 Highly Informative Direct
Biological Process (BP) response to molecule of bacterial origin 0 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.00000000000001783 Highly Informative Direct
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.00000000009101 Highly Informative Direct
Biological Process (BP) negative regulation of response to external stimulus 0.0000000002879 Highly Informative Direct
Biological Process (BP) developmental growth involved in morphogenesis 0.0000000003039 Highly Informative Direct
Biological Process (BP) negative regulation of locomotion 0.000000001686 Highly Informative Direct
Biological Process (BP) regulation of cell size 0.000000002501 Highly Informative Direct
Biological Process (BP) sex differentiation 0.00000002547 Highly Informative Direct
Biological Process (BP) positive regulation of cellular component biogenesis 0.00000003406 Highly Informative Direct
Biological Process (BP) regulation of toll-like receptor signaling pathway 0.00000003674 Highly Informative Direct
Biological Process (BP) negative regulation of cellular component movement 0.00000006802 Highly Informative Direct
Biological Process (BP) sensory organ morphogenesis 0.00000009146 Highly Informative Direct
Biological Process (BP) cellular component assembly involved in morphogenesis 0.0000002415 Highly Informative Direct
Biological Process (BP) positive regulation of protein kinase B signaling 0.000001164 Highly Informative Direct
Biological Process (BP) lymphocyte activation 0.000005565 Highly Informative Direct
Biological Process (BP) negative regulation of growth 0.00000785 Highly Informative Direct
Biological Process (BP) positive regulation of nervous system development 0.000009564 Highly Informative Direct
Biological Process (BP) regulation of neuron apoptotic process 0.00001514 Highly Informative Direct
Biological Process (BP) spermatogenesis 0.00002027 Highly Informative Direct
Biological Process (BP) actomyosin structure organization 0.00002864 Highly Informative Direct
Biological Process (BP) regeneration 0.0001244 Highly Informative Direct
Biological Process (BP) regulation of blood pressure 0.0001489 Highly Informative Direct
Biological Process (BP) response to peptide hormone 0.0002205 Highly Informative Direct
Biological Process (BP) negative regulation of immune system process 0.0002207 Highly Informative Direct
Biological Process (BP) coagulation 0.0003893 Highly Informative Direct
Biological Process (BP) anatomical structure homeostasis 0.0006103 Highly Informative Direct
Biological Process (BP) regulation of reproductive process 1 Highly Informative Inherited
Biological Process (BP) regulation of GTPase activity 0.001646 Highly Informative Inherited
Biological Process (BP) regulation of binding 0.02749 Highly Informative Inherited
Biological Process (BP) cellular response to organonitrogen compound 0.2134 Highly Informative Inherited
Biological Process (BP) divalent metal ion transport 0.384 Highly Informative Inherited
Biological Process (BP) inorganic cation transmembrane transport 0.3856 Highly Informative Inherited
Biological Process (BP) leukocyte migration 0.3417 Highly Informative Inherited
Biological Process (BP) multicellular organismal homeostasis 1 Highly Informative Inherited
Biological Process (BP) epithelial cell differentiation 1 Highly Informative Inherited
Biological Process (BP) kidney development 0.2354 Highly Informative Inherited
Biological Process (BP) actin filament organization 0.8099 Highly Informative Inherited
Biological Process (BP) positive regulation of cell development 0.898 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.01942 Highly Informative Inherited
Biological Process (BP) hemostasis 0.174 Highly Informative Inherited
Biological Process (BP) camera-type eye development 0.1405 Highly Informative Inherited
Biological Process (BP) cytokine-mediated signaling pathway 0.007883 Highly Informative Inherited
Biological Process (BP) response to virus 0.07227 Highly Informative Inherited
Biological Process (BP) positive regulation of supramolecular fiber organization 0.2203 Highly Informative Inherited
Biological Process (BP) cellular calcium ion homeostasis 0.3171 Highly Informative Inherited
Biological Process (BP) negative regulation of homeostatic process 0.2545 Highly Informative Inherited
Biological Process (BP) regulation of ion homeostasis 0.4284 Highly Informative Inherited
Biological Process (BP) neurological system process 0.09897 Highly Informative Inherited
Biological Process (BP) immune response-activating signal transduction 0.04074 Highly Informative Inherited
Biological Process (BP) glycosaminoglycan metabolic process 1 Highly Informative Inherited
Biological Process (BP) negative regulation of nervous system development 0.291 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.05352 Highly Informative Inherited
Biological Process (BP) positive regulation of lipid metabolic process 0.006663 Highly Informative Inherited
Biological Process (BP) regulation of cellular ketone metabolic process 0.566 Highly Informative Inherited
Biological Process (BP) negative regulation of lipid metabolic process 0.04997 Highly Informative Inherited
Biological Process (BP) response to alcohol 1 Highly Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 0.006259 Highly Informative Inherited
Biological Process (BP) cell maturation 1 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 0.3867 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 1 Highly Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.01692 Highly Informative Inherited
Biological Process (BP) positive regulation of proteolysis 0.01262 Highly Informative Inherited
Biological Process (BP) regulation of cysteine-type endopeptidase activity 0.7464 Highly Informative Inherited
Biological Process (BP) positive regulation of apoptotic process 0.9631 Highly Informative Inherited
Biological Process (BP) activation of protein kinase activity 0.5282 Highly Informative Inherited
Biological Process (BP) cell proliferation 0.1347 Highly Informative Inherited
Biological Process (BP) macromolecule glycosylation 0.6289 Highly Informative Inherited
Biological Process (BP) phenol-containing compound metabolic process 0.003174 Highly Informative Inherited
Biological Process (BP) innate immune response 0.1247 Highly Informative Inherited
Biological Process (BP) multicellular organism metabolic process 0.01554 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 1 Highly Informative Inherited
Biological Process (BP) response to nutrient levels 0.7089 Highly Informative Inherited
Biological Process (BP) positive regulation of response to external stimulus 0.01289 Highly Informative Inherited
Biological Process (BP) regulation of cell killing 0.001495 Highly Informative Inherited
Biological Process (BP) regulation of cell growth 0.009494 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.001629 Highly Informative Inherited
Biological Process (BP) muscle structure development 0.01743 Highly Informative Inherited
Biological Process (BP) glycoprotein metabolic process 0.00905 Highly Informative Inherited
Biological Process (BP) cell projection assembly 1 Highly Informative Inherited
Biological Process (BP) protein maturation 0.003348 Highly Informative Inherited
Biological Process (BP) regulation of lipid localization 0.8011 Highly Informative Inherited
Biological Process (BP) negative regulation of cell development 0.5959 Highly Informative Inherited
Biological Process (BP) regulation of epithelial cell migration 0.1129 Highly Informative Inherited
Biological Process (BP) pattern specification process 1 Highly Informative Inherited
Biological Process (BP) wound healing 0.9814 Highly Informative Inherited
Biological Process (BP) muscle system process 0.7656 Highly Informative Inherited
Biological Process (BP) neutral lipid metabolic process 0.003198 Highly Informative Inherited
Biological Process (BP) protein lipidation 0.5483 Highly Informative Inherited
Biological Process (BP) post-translational protein modification 0.8198 Highly Informative Inherited
Biological Process (BP) negative regulation of transferase activity 0.006246 Highly Informative Inherited
Biological Process (BP) negative regulation of protein modification process 0.6722 Highly Informative Inherited
Biological Process (BP) negative regulation of phosphate metabolic process 0.941 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 1 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 1 Highly Informative Inherited
Biological Process (BP) tube morphogenesis 1 Highly Informative Inherited
Biological Process (BP) renal system process 0.01047 Highly Informative Inherited
Biological Process (BP) positive regulation of adaptive immune response based on somatic recombination of immune receptors b 1 Highly Informative Inherited
Biological Process (BP) inflammatory response 0.02164 Highly Informative Inherited
Biological Process (BP) leukocyte differentiation 0.4272 Highly Informative Inherited
Biological Process (BP) angiogenesis 0.00702 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 0.4964 Highly Informative Inherited
Biological Process (BP) regulation of epithelial cell proliferation 0.02688 Highly Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.00475 Highly Informative Inherited
Biological Process (BP) microtubule cytoskeleton organization 1 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) transferase activity 0.00000002775 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) structural molecule activity 0.000000000000922 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 0.0000000000124 Moderately Informative Direct
Molecular Function (MF) anion binding 0.0000399 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.1983 Moderately Informative Inherited
Molecular Function (MF) molecular function regulator 1 Moderately Informative Inherited
Molecular Function (MF) sulfur compound binding 0 Informative Direct
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0 Informative Direct
Molecular Function (MF) phosphatase activity 0 Informative Direct
Molecular Function (MF) signal transducer activity 0 Informative Direct
Molecular Function (MF) identical protein binding 0.00000000000001397 Informative Direct
Molecular Function (MF) protein dimerization activity 0.0000000004711 Informative Direct
Molecular Function (MF) amide binding 0.01078 Informative Inherited
Molecular Function (MF) enzyme binding 1 Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 1 Informative Inherited
Molecular Function (MF) macromolecular complex binding 0.0603 Informative Inherited
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) heparin binding 0 Highly Informative Direct
Molecular Function (MF) transmembrane signaling receptor activity 0 Highly Informative Direct
Molecular Function (MF) phosphoprotein phosphatase activity 0 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0 Highly Informative Direct
Molecular Function (MF) cell adhesion molecule binding 0.000000000001938 Highly Informative Direct
Molecular Function (MF) hormone binding 0.0000000003881 Highly Informative Direct
Molecular Function (MF) peptide binding 0.0000009273 Highly Informative Direct
Molecular Function (MF) protein homodimerization activity 0.00008402 Highly Informative Direct
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0.0005227 Highly Informative Direct
Molecular Function (MF) kinase binding 0.0009884 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0.05337 Highly Informative Inherited
Molecular Function (MF) UDP-glycosyltransferase activity 0.0145 Highly Informative Inherited
Molecular Function (MF) transferase activity, transferring hexosyl groups 0.1507 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) macromolecular complex 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) intrinsic component of membrane 0 Moderately Informative Direct
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) vesicle 0.00003111 Moderately Informative Direct
Cellular Component (CC) endoplasmic reticulum 0.0008071 Moderately Informative Direct
Cellular Component (CC) bounding membrane of organelle 0.9999 Moderately Informative Inherited
Cellular Component (CC) whole membrane 1 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.9645 Moderately Informative Inherited
Cellular Component (CC) cell surface 0 Informative Direct
Cellular Component (CC) synapse 0 Informative Direct
Cellular Component (CC) neuron projection 0 Informative Direct
Cellular Component (CC) apical part of cell 0.000000003153 Informative Direct
Cellular Component (CC) extracellular organelle 0.00001026 Informative Direct
Cellular Component (CC) plasma membrane bounded cell projection part 1 Informative Inherited
Cellular Component (CC) extracellular space 1 Informative Inherited
Cellular Component (CC) supramolecular polymer 0.8853 Informative Inherited
Cellular Component (CC) endosome 0.002661 Informative Inherited
Cellular Component (CC) cytoplasmic vesicle part 0.009162 Informative Inherited
Cellular Component (CC) actin cytoskeleton 1 Informative Inherited
Cellular Component (CC) plasma membrane region 0.2481 Informative Inherited
Cellular Component (CC) contractile fiber part 0 Highly Informative Direct
Cellular Component (CC) intrinsic component of plasma membrane 0 Highly Informative Direct
Cellular Component (CC) neuronal cell body 0.00000001055 Highly Informative Direct
Cellular Component (CC) dendrite 0.00000004406 Highly Informative Direct
Cellular Component (CC) receptor complex 0.00000005722 Highly Informative Direct
Cellular Component (CC) apical plasma membrane 0.0000005445 Highly Informative Direct
Cellular Component (CC) extracellular matrix component 0.00001637 Highly Informative Direct
Cellular Component (CC) myofibril 0.0001769 Highly Informative Direct
Cellular Component (CC) lateral plasma membrane 0.0007657 Highly Informative Direct
Cellular Component (CC) growth cone 0.004937 Highly Informative Inherited
Cellular Component (CC) endosome membrane 0.00159 Highly Informative Inherited
Cellular Component (CC) cell-substrate adherens junction 1 Highly Informative Inherited
Cellular Component (CC) cell-cell junction 0.3812 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0.000000000000007826Least InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl0.00000000004277Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.1816Moderately InformativeInherited
Enzyme Commission (EC)Receptor protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0InformativeDirect
Enzyme Commission (EC)Chitinase0.0002219Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.5337Least InformativeInherited
Disease Ontology (DO)urinary system disease0.2328Moderately InformativeInherited
Disease Ontology (DO)neurodegenerative disease0.4821Moderately InformativeInherited
Disease Ontology (DO)disease by infectious agent0.5688Moderately InformativeInherited
Disease Ontology (DO)primary bacterial infectious disease0.7007InformativeInherited
Disease Ontology (DO)acute kidney failure0.000001606Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Functional respiratory abnormality0.7582Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal pattern of respiration0.1406InformativeInherited
Phenotypic Abnormality (PA)Nocturnal hypoventilation0.0005083Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.007552Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.2381Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.6389Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.6611Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.9243Least InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.004932Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.02603Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.1199Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development0.1612Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.2429Moderately InformativeInherited
Mammalian Phenotype (MP)reproductive system phenotype0.5308Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.7979Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal circulating cytokine level0.000002585InformativeDirect
Mammalian Phenotype (MP)autoimmune response0.0001153InformativeDirect
Mammalian Phenotype (MP)abnormal cell differentiation0.002678InformativeInherited
Mammalian Phenotype (MP)abnormal heart layer morphology0.1185InformativeInherited
Mammalian Phenotype (MP)abnormal female reproductive system physiology0.2116InformativeInherited
Mammalian Phenotype (MP)abnormal white adipose tissue morphology0.3786InformativeInherited
Mammalian Phenotype (MP)abnormal interferon level0.4812InformativeInherited
Mammalian Phenotype (MP)abnormal spermatogenesis0.6074InformativeInherited
Mammalian Phenotype (MP)increased apoptosis0.8077InformativeInherited
Mammalian Phenotype (MP)abnormal adipose tissue amount0.8303InformativeInherited
Mammalian Phenotype (MP)abnormal axon guidance0.0004425Highly InformativeDirect
Mammalian Phenotype (MP)abnormal spermiogenesis0.08893Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell morphology variant0.00003112Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.0002974Least InformativeDirect
Worm Phenotype (WP)cell development variant0.001073Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.007133Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.03738Least InformativeInherited
Worm Phenotype (WP)nervous system morphology variant0.001307Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.01166Moderately InformativeInherited
Worm Phenotype (WP)reproductive system development variant0.02636Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.03594Moderately InformativeInherited
Worm Phenotype (WP)cell component morphology variant0.9942Moderately InformativeInherited
Worm Phenotype (WP)protein degradation variant0.00000452InformativeDirect
Worm Phenotype (WP)locomotion reduced0.000005021InformativeDirect
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.00005747InformativeDirect
Worm Phenotype (WP)body posture variant0.0002947InformativeDirect
Worm Phenotype (WP)mitochondria morphology variant0.0003564InformativeDirect
Worm Phenotype (WP)neuronal outgrowth variant0.0007491InformativeDirect
Worm Phenotype (WP)growth rate variant0.0009812InformativeDirect
Worm Phenotype (WP)locomotor coordination variant0.001952InformativeInherited
Worm Phenotype (WP)muscle cell physiology variant0.00468InformativeInherited
Worm Phenotype (WP)forward locomotion variant0.02583InformativeInherited
Worm Phenotype (WP)anchor cell invasion variant0.00000000003576Highly InformativeDirect
Worm Phenotype (WP)muscle arm development defective0.000000005149Highly InformativeDirect
Worm Phenotype (WP)axon morphology variant0.00000002569Highly InformativeDirect
Worm Phenotype (WP)forward locomotion decreased0.00004101Highly InformativeDirect
Worm Phenotype (WP)loss of left right asymmetry0.09594Highly InformativeInherited
Worm Phenotype (WP)neuronal cell fate specification variant0.1918Highly InformativeInherited
Worm Phenotype (WP)axon development variant0.383Highly InformativeInherited
Worm Phenotype (WP)path curvature variant0.73Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)cell adhesion defective0.0009125Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)anatomical group0.0001358Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0.0003176Least InformativeDirect
Fly Anatomy (FA)larva0.01923Least InformativeInherited
Fly Anatomy (FA)nervous system0.02393Least InformativeInherited
Fly Anatomy (FA)adult0.04455Least InformativeInherited
Fly Anatomy (FA)somatic cell0.3387Least InformativeInherited
Fly Anatomy (FA)integumentary system0.4424Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.00000008372Moderately InformativeDirect
Fly Anatomy (FA)larval tagma0.001135Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.0236Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.03084Moderately InformativeInherited
Fly Anatomy (FA)late embryo0.04049Moderately InformativeInherited
Fly Anatomy (FA)cell cluster organ0.05145Moderately InformativeInherited
Fly Anatomy (FA)sense organ0.09864Moderately InformativeInherited
Fly Anatomy (FA)adult segment0.209Moderately InformativeInherited
Fly Anatomy (FA)neuron0.2789Moderately InformativeInherited
Fly Anatomy (FA)adult thorax0.7537Moderately InformativeInherited
Fly Anatomy (FA)tagmatic subdivision of integument0.8994Moderately InformativeInherited
Fly Anatomy (FA)appendage0.926Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.9516Moderately InformativeInherited
Fly Anatomy (FA)thoracic segment1Moderately InformativeInherited
Fly Anatomy (FA)larval abdomen0.000004594InformativeDirect
Fly Anatomy (FA)synaptic neuropil0.00007663InformativeDirect
Fly Anatomy (FA)chemosensory system0.03384InformativeInherited
Fly Anatomy (FA)chaeta0.04632InformativeInherited
Fly Anatomy (FA)leg0.3219InformativeInherited
Fly Anatomy (FA)ipsilateral tract0.7917InformativeInherited
Fly Anatomy (FA)connective0.000001341Highly InformativeDirect
Fly Anatomy (FA)commissure0.000005353Highly InformativeDirect
Fly Anatomy (FA)thoracic T1 neuron0.00004658Highly InformativeDirect
Fly Anatomy (FA)prothoracic leg taste bristle0.0003468Highly InformativeDirect
Fly Anatomy (FA)chemosensory neuron0.006236Highly InformativeInherited
Fly Anatomy (FA)eo neuron0.06152Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)multi-tissue structure0.07714Least InformativeInherited
Zebrafish Anatomy (ZA)compound organ0.09427Least InformativeInherited
Zebrafish Anatomy (ZA)nervous system0.4917Least InformativeInherited
Zebrafish Anatomy (ZA)central nervous system0.2218Moderately InformativeInherited
Zebrafish Anatomy (ZA)forebrain0.03059InformativeInherited
Zebrafish Anatomy (ZA)medial longitudinal fasciculus0.00002898Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus DEvelopment stage (XDE)NF stage0.00000002831Least InformativeDirect
Xenopus DEvelopment stage (XDE)embryonic stage0.0000008867Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases0.0000006823Least InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosylases0.00001906Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.1128Moderately InformativeInherited
Enzyme Commission (EC)Acyltransferases0.8987Moderately InformativeInherited
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0InformativeDirect
Enzyme Commission (EC)RING-type E3 ubiquitin transferase0.0000000001712InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0Highly InformativeDirect
Enzyme Commission (EC)Chitinase0.0006049Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation0Moderately InformativeDirect
Biological processCarbohydrate metabolism0.1639Moderately InformativeInherited
Biological processAngiogenesis0InformativeDirect
Biological processCell adhesion0InformativeDirect
Biological processEndocytosis0InformativeDirect
Biological processNeurogenesis0InformativeDirect
Biological processHemostasis0.000002966InformativeDirect
Biological processPolysaccharide degradation0.00005494InformativeDirect
Biological processChemotaxis0.0005069InformativeDirect
Biological processSensory transduction0.03893InformativeInherited
Biological processAcute phase0.000000000001931Highly InformativeDirect
Biological processNotch signaling pathway0.000000015Highly InformativeDirect
Biological processBlood coagulation0.000002819Highly InformativeDirect
Biological processVision0.00003241Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentEndosome0.000000004074Moderately InformativeDirect
Cellular componentCytoskeleton0.000000335Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.0006504Moderately InformativeDirect
Cellular componentExtracellular matrix0InformativeDirect
Cellular componentGPI-anchor0InformativeDirect
Coding sequence diversityAlternative splicing0.000004938Least InformativeDirect
DiseaseDisease mutation0.000009807Least InformativeDirect
DomainRepeat0Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
DomainImmunoglobulin domain0InformativeDirect
DomainEGF-like domain0.000000000000001855InformativeDirect
DomainLeucine-rich repeat0.00000000000001572InformativeDirect
DomainCollagen0.000000006527Highly InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationHeparin-binding0InformativeDirect
Post-translational modificationProtein phosphatase0InformativeDirect
Post-translational modificationCalmodulin-binding0.000003164InformativeDirect
Post-translational modificationActin-binding0.00001979InformativeDirect
Post-translational modificationGlycosidase0.0002421InformativeDirect
Post-translational modificationMuscle protein0Highly InformativeDirect
Post-translational modificationTyrosine-protein kinase0Highly InformativeDirect
Post-translational modificationCytokine0.000000000000002832Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationProteoglycan0.000002919InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein glycosylation0.00000003451InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR008957 SSF49265 Protein matches
Abstract

Fibronectin is composed of three repeating structural motifs, of which one is the FnIII module. The three modules form a linear sequence of multiple tandem copies connected by short linker peptides. The secondary structure of the FnIII10 module, which is the only fibronectin module to possess an integrin binding RGD motif, consists of two beta-sheets containing the antiparallel beta-strands ABE and DCFG, respectively, which fold up to form a beta-sandwich. The RGD sequence is located in the loop connecting the beta-strands [PubMed9990027].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 111 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Fibronectin type III domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 111 hidden Markov models representing the Fibronectin type III superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]