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Fibronectin type III superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Immunoglobulin-like beta-sandwich [ 48725] (28)
Superfamily:   Fibronectin type III [ 49265]
Families:   Fibronectin type III [ 49266] (44)


Superfamily statistics
Genomes (1,736) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 71,149 265,201 172
Proteins 29,622 129,837 117


Functional annotation
General category Processes_EC
Detailed category Cell adhesion

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0.000000000000007826Least InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl0.00000000004277Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.1816Moderately InformativeInherited
Enzyme Commission (EC)Receptor protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0InformativeDirect
Enzyme Commission (EC)Chitinase0.0002219Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.5691Least InformativeInherited
Disease Ontology (DO)urinary system disease0.2508Moderately InformativeInherited
Disease Ontology (DO)neurodegenerative disease0.4827Moderately InformativeInherited
Disease Ontology (DO)disease by infectious agent0.5928Moderately InformativeInherited
Disease Ontology (DO)primary bacterial infectious disease0.7034InformativeInherited
Disease Ontology (DO)acute kidney failure0.000001647Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.007487Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.2365Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.6332Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.6518Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.9234Least InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.004659Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.02538Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.1175Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development0.1596Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.2405Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.2562Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.8019Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system physiology0.919Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal circulating cytokine level0.000002589InformativeDirect
Mammalian Phenotype (MP)autoimmune response0.000116InformativeDirect
Mammalian Phenotype (MP)abnormal cell differentiation0.002675InformativeInherited
Mammalian Phenotype (MP)abnormal heart layer morphology0.1188InformativeInherited
Mammalian Phenotype (MP)abnormal female reproductive system physiology0.2122InformativeInherited
Mammalian Phenotype (MP)abnormal white adipose tissue morphology0.3821InformativeInherited
Mammalian Phenotype (MP)abnormal interferon level0.4742InformativeInherited
Mammalian Phenotype (MP)abnormal spermatogenesis0.6056InformativeInherited
Mammalian Phenotype (MP)increased apoptosis0.8053InformativeInherited
Mammalian Phenotype (MP)abnormal adipose tissue amount0.8322InformativeInherited
Mammalian Phenotype (MP)abnormal axon guidance0.0004413Highly InformativeDirect
Mammalian Phenotype (MP)abnormal spermiogenesis0.08905Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell morphology variant0.000002819Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.0004681Least InformativeDirect
Worm Phenotype (WP)cell development variant0.001916Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.003093Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.2095Least InformativeInherited
Worm Phenotype (WP)neuron development variant0.00000001806Moderately InformativeDirect
Worm Phenotype (WP)movement variant0.000004422Moderately InformativeDirect
Worm Phenotype (WP)metabolic pathway variant0.0004485Moderately InformativeDirect
Worm Phenotype (WP)nervous system morphology variant0.002463Moderately InformativeInherited
Worm Phenotype (WP)locomotion variant0.01957Moderately InformativeInherited
Worm Phenotype (WP)reproductive system development variant0.02731Moderately InformativeInherited
Worm Phenotype (WP)axon outgrowth variant0.00000000001865InformativeDirect
Worm Phenotype (WP)anchor cell invasion variant0.00000000006721InformativeDirect
Worm Phenotype (WP)locomotion reduced0.000006416InformativeDirect
Worm Phenotype (WP)neuron morphology variant0.00003788InformativeDirect
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.00005754InformativeDirect
Worm Phenotype (WP)body posture variant0.0004123InformativeDirect
Worm Phenotype (WP)mitochondria morphology variant0.005703InformativeInherited
Worm Phenotype (WP)cell fate specification variant0.02205InformativeInherited
Worm Phenotype (WP)forward locomotion variant0.03459InformativeInherited
Worm Phenotype (WP)cell component localization variant0.2442InformativeInherited
Worm Phenotype (WP)directionality variant0.5955InformativeInherited
Worm Phenotype (WP)muscle arm development defective0.000000004944Highly InformativeDirect
Worm Phenotype (WP)forward locomotion decreased0.00004411Highly InformativeDirect
Worm Phenotype (WP)axon trajectory variant0.02545Highly InformativeInherited
Worm Phenotype (WP)loss of left right asymmetry0.0922Highly InformativeInherited
Worm Phenotype (WP)neuronal cell fate specification variant0.2028Highly InformativeInherited
Worm Phenotype (WP)path curvature variant0.7066Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system subdivision0.0005174Least InformativeDirect
Fly Anatomy (FA)nervous system0.0113Least InformativeInherited
Fly Anatomy (FA)larva0.03313Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.04144Least InformativeInherited
Fly Anatomy (FA)adult0.2258Least InformativeInherited
Fly Anatomy (FA)somatic cell0.3004Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.000000001045Moderately InformativeDirect
Fly Anatomy (FA)ganglion0.001881Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.005109Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.02901Moderately InformativeInherited
Fly Anatomy (FA)late embryo0.07503Moderately InformativeInherited
Fly Anatomy (FA)sensory system0.1197Moderately InformativeInherited
Fly Anatomy (FA)neuron0.2234Moderately InformativeInherited
Fly Anatomy (FA)adult segment0.2364Moderately InformativeInherited
Fly Anatomy (FA)adult nervous system0.2573Moderately InformativeInherited
Fly Anatomy (FA)head0.6585Moderately InformativeInherited
Fly Anatomy (FA)somatic precursor cell0.665Moderately InformativeInherited
Fly Anatomy (FA)adult tagma0.7714Moderately InformativeInherited
Fly Anatomy (FA)larval abdomen0.0000006177InformativeDirect
Fly Anatomy (FA)synaptic neuropil0.00001077InformativeDirect
Fly Anatomy (FA)primordium0.02227InformativeInherited
Fly Anatomy (FA)adult procephalic segment0.03034InformativeInherited
Fly Anatomy (FA)brain0.0356InformativeInherited
Fly Anatomy (FA)chemosensory system0.04071InformativeInherited
Fly Anatomy (FA)neuromere0.07582InformativeInherited
Fly Anatomy (FA)dorsal closure embryo0.1215InformativeInherited
Fly Anatomy (FA)adult central nervous system0.1692InformativeInherited
Fly Anatomy (FA)tract0.3837InformativeInherited
Fly Anatomy (FA)leg taste bristle chemosensory neuron0.00001369Highly InformativeDirect
Fly Anatomy (FA)commissure0.00002549Highly InformativeDirect
Fly Anatomy (FA)embryonic heart cardioblast0.00003685Highly InformativeDirect
Fly Anatomy (FA)lobe system of adult mushroom body0.0001701Highly InformativeDirect
Fly Anatomy (FA)LNv neuron0.0001725Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)compound organ0.1738Least InformativeInherited
Zebrafish Anatomy (ZA)multi-tissue structure0.2154Least InformativeInherited
Zebrafish Anatomy (ZA)nervous system0.6784Least InformativeInherited
Zebrafish Anatomy (ZA)central nervous system0.3378Moderately InformativeInherited
Zebrafish Anatomy (ZA)sensory system0.748Moderately InformativeInherited
Zebrafish Anatomy (ZA)forebrain0.03945InformativeInherited
Zebrafish Anatomy (ZA)medial longitudinal fasciculus0.00002125Highly InformativeDirect
Zebrafish Anatomy (ZA)glomerular layer0.0003174Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)head0.9226Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.9757Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical system1Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue1Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.1041Moderately InformativeInherited
Xenopus ANatomical entity (XAN)sensory system0.2687Moderately InformativeInherited
Xenopus ANatomical entity (XAN)eye0.2871InformativeInherited
Xenopus ANatomical entity (XAN)retinal ganglion cell layer0.0001568Highly InformativeDirect
Xenopus ANatomical entity (XAN)retinal inner nuclear layer0.0009739Highly InformativeDirect
Xenopus DEvelopment stage (XDE)embryonic stage0.000002304Moderately InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases0.0000005947Least InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Aminoacyltransferases0.000001003Moderately InformativeDirect
Enzyme Commission (EC)Glycosylases0.00007381Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.1426Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases0.8031Moderately InformativeInherited
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0InformativeDirect
Enzyme Commission (EC)RING-type E3 ubiquitin transferase0.0000000008289InformativeDirect
Enzyme Commission (EC)Hexosyltransferases0.000019InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0Highly InformativeDirect
Enzyme Commission (EC)Chitinase0.0006786Highly InformativeDirect

Document: EC annotation of SCOP domains

InterPro annotation
Cross references IPR008957 SSF49265 Protein matches
Abstract

Fibronectin is composed of three repeating structural motifs, of which one is the FnIII module. The three modules form a linear sequence of multiple tandem copies connected by short linker peptides. The secondary structure of the FnIII10 module, which is the only fibronectin module to possess an integrin binding RGD motif, consists of two beta-sheets containing the antiparallel beta-strands ABE and DCFG, respectively, which fold up to form a beta-sandwich. The RGD sequence is located in the loop connecting the beta-strands [PubMed9990027].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 169 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Fibronectin type III domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 169 hidden Markov models representing the Fibronectin type III superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]