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Fibronectin type III superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Immunoglobulin-like beta-sandwich [ 48725] (28)
Superfamily:   Fibronectin type III [ 49265]
Families:   Fibronectin type III [ 49266] (44)


Superfamily statistics
Genomes (1,729) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 69,853 91,738 172
Proteins 29,037 47,558 117


Functional annotation
General category Processes_EC
Detailed category Cell adhesion

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism cellular process0.018220Least InformativeInherited
Biological Process (BP)cellular developmental process0.0049780Moderately InformativeInherited
Biological Process (BP)locomotion0.000040060InformativeDirect
Biological Process (BP)cell development0.000073880InformativeDirect
Biological Process (BP)movement of cell or subcellular component0.00028330InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) macromolecule metabolic process 0.000000000002246 Least Informative Direct
Biological Process (BP) primary metabolic process 0.1093 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) system development 0 Moderately Informative Direct
Biological Process (BP) cellular developmental process 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0 Moderately Informative Direct
Biological Process (BP) response to external stimulus 0 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0 Moderately Informative Direct
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) signaling 0 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.000000000001882 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.00000000007767 Moderately Informative Direct
Biological Process (BP) cell communication 0.0000000007241 Moderately Informative Direct
Biological Process (BP) single-organism transport 0.000000006083 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0.0004871 Moderately Informative Direct
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.9678 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to stress 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.0312 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.002352 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.8208 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.01227 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.02444 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) cell development 0 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0 Informative Direct
Biological Process (BP) regulation of cell differentiation 0 Informative Direct
Biological Process (BP) cellular component morphogenesis 0 Informative Direct
Biological Process (BP) central nervous system development 0 Informative Direct
Biological Process (BP) cell surface receptor signaling pathway 0 Informative Direct
Biological Process (BP) growth 0 Informative Direct
Biological Process (BP) regulation of nervous system development 0 Informative Direct
Biological Process (BP) generation of neurons 0 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.000000000003643 Informative Direct
Biological Process (BP) regulation of apoptotic process 0.000000000005126 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.00000000004553 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.00000001124 Informative Direct
Biological Process (BP) positive regulation of developmental process 0.0000001862 Informative Direct
Biological Process (BP) positive regulation of cellular protein metabolic process 0.0000002551 Informative Direct
Biological Process (BP) cytoskeleton organization 0.000003559 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.00001319 Informative Direct
Biological Process (BP) response to cytokine 0.00002338 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.00002354 Informative Direct
Biological Process (BP) regulation of locomotion 0.00002387 Informative Direct
Biological Process (BP) response to bacterium 0.00002595 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.00004592 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.00008848 Informative Direct
Biological Process (BP) cell adhesion 0.00009448 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0.0001384 Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.0002321 Informative Direct
Biological Process (BP) phosphorylation 0.0006175 Informative Direct
Biological Process (BP) regulation of hydrolase activity 0.002484 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.9532 Informative Inherited
Biological Process (BP) response to nitrogen compound 1 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 1 Informative Inherited
Biological Process (BP) metal ion transport 1 Informative Inherited
Biological Process (BP) ion homeostasis 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.00347 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.008636 Informative Inherited
Biological Process (BP) organelle assembly 0.002769 Informative Inherited
Biological Process (BP) epithelium development 0.8589 Informative Inherited
Biological Process (BP) actin filament-based process 0.005992 Informative Inherited
Biological Process (BP) circulatory system development 0.663 Informative Inherited
Biological Process (BP) regulation of proteolysis 0.3053 Informative Inherited
Biological Process (BP) multi-organism cellular process 0.0243 Informative Inherited
Biological Process (BP) defense response to other organism 1 Informative Inherited
Biological Process (BP) protein oligomerization 0.1691 Informative Inherited
Biological Process (BP) transmembrane transport 1 Informative Inherited
Biological Process (BP) system process 0.00125 Informative Inherited
Biological Process (BP) regulation of immune response 0.5854 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.3548 Informative Inherited
Biological Process (BP) regulation of defense response 1 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.001395 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.151 Informative Inherited
Biological Process (BP) regulation of growth 0.004411 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.367 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 1 Informative Inherited
Biological Process (BP) single-organism membrane organization 1 Informative Inherited
Biological Process (BP) negative regulation of cell death 0.01235 Informative Inherited
Biological Process (BP) positive regulation of cell death 0.6608 Informative Inherited
Biological Process (BP) regulation of transferase activity 1 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 1 Informative Inherited
Biological Process (BP) single organism reproductive process 0.9795 Informative Inherited
Biological Process (BP) regulation of phosphorylation 0.001735 Informative Inherited
Biological Process (BP) mitotic cell cycle 1 Informative Inherited
Biological Process (BP) microtubule-based process 1 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.9382 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.3595 Informative Inherited
Biological Process (BP) secondary metabolic process 0.2605 Informative Inherited
Biological Process (BP) pigment metabolic process 0.01251 Informative Inherited
Biological Process (BP) immune response 0.062 Informative Inherited
Biological Process (BP) regulation of organelle organization 1 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.002954 Informative Inherited
Biological Process (BP) regulation of cytokine production 1 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.9463 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.7013 Informative Inherited
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 0.003486 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) multicellular organism reproduction 1 Informative Inherited
Biological Process (BP) multi-organism reproductive process 1 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 1 Informative Inherited
Biological Process (BP) glycerolipid metabolic process 0.6155 Informative Inherited
Biological Process (BP) regulation of protein modification process 0.001607 Informative Inherited
Biological Process (BP) negative regulation of cellular protein metabolic process 1 Informative Inherited
Biological Process (BP) negative regulation of molecular function 1 Informative Inherited
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) proteolysis 1 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.003658 Informative Inherited
Biological Process (BP) embryo development 1 Informative Inherited
Biological Process (BP) reproductive system development 1 Informative Inherited
Biological Process (BP) cell cycle process 1 Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0 Highly Informative Direct
Biological Process (BP) chemotaxis 0 Highly Informative Direct
Biological Process (BP) response to molecule of bacterial origin 0 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0 Highly Informative Direct
Biological Process (BP) brain development 0 Highly Informative Direct
Biological Process (BP) protein dephosphorylation 0 Highly Informative Direct
Biological Process (BP) response to mechanical stimulus 0 Highly Informative Direct
Biological Process (BP) cell growth 0 Highly Informative Direct
Biological Process (BP) cell projection organization 0 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0 Highly Informative Direct
Biological Process (BP) neuron development 0 Highly Informative Direct
Biological Process (BP) regulation of neuron projection development 0 Highly Informative Direct
Biological Process (BP) positive regulation of cell adhesion 0.000000000000003692 Highly Informative Direct
Biological Process (BP) detection of stimulus 0.0000000000000208 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.0000000000004307 Highly Informative Direct
Biological Process (BP) lymphocyte activation 0.00000000001421 Highly Informative Direct
Biological Process (BP) developmental growth involved in morphogenesis 0.00000000007634 Highly Informative Direct
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.0000000001091 Highly Informative Direct
Biological Process (BP) cell junction assembly 0.0000000003805 Highly Informative Direct
Biological Process (BP) endocytosis 0.000000003632 Highly Informative Direct
Biological Process (BP) cellular component assembly involved in morphogenesis 0.00000001069 Highly Informative Direct
Biological Process (BP) sex differentiation 0.00000001756 Highly Informative Direct
Biological Process (BP) regulation of cell size 0.00000004052 Highly Informative Direct
Biological Process (BP) regulation of toll-like receptor signaling pathway 0.00000005214 Highly Informative Direct
Biological Process (BP) positive regulation of cellular component biogenesis 0.00000005778 Highly Informative Direct
Biological Process (BP) negative regulation of locomotion 0.00000007741 Highly Informative Direct
Biological Process (BP) sensory organ morphogenesis 0.0000001033 Highly Informative Direct
Biological Process (BP) regulation of response to wounding 0.0000001622 Highly Informative Direct
Biological Process (BP) negative regulation of cellular component movement 0.0000005057 Highly Informative Direct
Biological Process (BP) negative regulation of response to external stimulus 0.0000006071 Highly Informative Direct
Biological Process (BP) cell migration 0.000001348 Highly Informative Direct
Biological Process (BP) positive regulation of protein kinase B signaling 0.000001361 Highly Informative Direct
Biological Process (BP) actomyosin structure organization 0.000002412 Highly Informative Direct
Biological Process (BP) positive regulation of nervous system development 0.0000114 Highly Informative Direct
Biological Process (BP) spermatogenesis 0.00001656 Highly Informative Direct
Biological Process (BP) regulation of neuron apoptotic process 0.00001849 Highly Informative Direct
Biological Process (BP) regulation of blood pressure 0.0000668 Highly Informative Direct
Biological Process (BP) response to peptide hormone 0.0001784 Highly Informative Direct
Biological Process (BP) coagulation 0.0001836 Highly Informative Direct
Biological Process (BP) regulation of leukocyte mediated immunity 0.0002464 Highly Informative Direct
Biological Process (BP) negative regulation of immune system process 0.0003875 Highly Informative Direct
Biological Process (BP) renal system process 0.000584 Highly Informative Direct
Biological Process (BP) negative regulation of growth 0.0006551 Highly Informative Direct
Biological Process (BP) anatomical structure homeostasis 0.0009427 Highly Informative Direct
Biological Process (BP) regulation of epithelial cell migration 0.1768 Highly Informative Inherited
Biological Process (BP) regulation of reproductive process 1 Highly Informative Inherited
Biological Process (BP) regulation of binding 0.01549 Highly Informative Inherited
Biological Process (BP) cellular response to organonitrogen compound 0.2211 Highly Informative Inherited
Biological Process (BP) multicellular organismal homeostasis 1 Highly Informative Inherited
Biological Process (BP) muscle structure development 0.008703 Highly Informative Inherited
Biological Process (BP) actin filament organization 1 Highly Informative Inherited
Biological Process (BP) positive regulation of cell development 0.8382 Highly Informative Inherited
Biological Process (BP) negative regulation of cell development 0.7157 Highly Informative Inherited
Biological Process (BP) hemostasis 0.2694 Highly Informative Inherited
Biological Process (BP) camera-type eye development 0.1539 Highly Informative Inherited
Biological Process (BP) cytokine-mediated signaling pathway 0.004479 Highly Informative Inherited
Biological Process (BP) regulation of cell growth 0.05819 Highly Informative Inherited
Biological Process (BP) divalent inorganic cation transport 0.3113 Highly Informative Inherited
Biological Process (BP) response to virus 0.03455 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 1 Highly Informative Inherited
Biological Process (BP) cellular calcium ion homeostasis 0.1786 Highly Informative Inherited
Biological Process (BP) inorganic cation transmembrane transport 0.2394 Highly Informative Inherited
Biological Process (BP) negative regulation of homeostatic process 0.1868 Highly Informative Inherited
Biological Process (BP) regulation of ion homeostasis 0.4388 Highly Informative Inherited
Biological Process (BP) sensory perception 0.1425 Highly Informative Inherited
Biological Process (BP) regulation of inflammatory response 0.04737 Highly Informative Inherited
Biological Process (BP) glycosaminoglycan metabolic process 1 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.08961 Highly Informative Inherited
Biological Process (BP) positive regulation of lipid metabolic process 0.006145 Highly Informative Inherited
Biological Process (BP) regulation of cellular ketone metabolic process 0.5492 Highly Informative Inherited
Biological Process (BP) negative regulation of lipid metabolic process 0.04483 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.002874 Highly Informative Inherited
Biological Process (BP) epithelial cell differentiation 1 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 1 Highly Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 0.01968 Highly Informative Inherited
Biological Process (BP) cell maturation 1 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 0.3917 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 1 Highly Informative Inherited
Biological Process (BP) leukocyte cell-cell adhesion 1 Highly Informative Inherited
Biological Process (BP) hemopoiesis 0.2493 Highly Informative Inherited
Biological Process (BP) positive regulation of apoptotic process 0.9719 Highly Informative Inherited
Biological Process (BP) activation of protein kinase activity 0.2251 Highly Informative Inherited
Biological Process (BP) macromolecule glycosylation 0.6701 Highly Informative Inherited
Biological Process (BP) innate immune response 0.1958 Highly Informative Inherited
Biological Process (BP) phenol-containing compound metabolic process 0.002186 Highly Informative Inherited
Biological Process (BP) multicellular organism metabolic process 0.01066 Highly Informative Inherited
Biological Process (BP) cell proliferation 0.1179 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 1 Highly Informative Inherited
Biological Process (BP) response to nutrient levels 0.8811 Highly Informative Inherited
Biological Process (BP) positive regulation of response to external stimulus 0.007091 Highly Informative Inherited
Biological Process (BP) regeneration 0.004623 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.1591 Highly Informative Inherited
Biological Process (BP) glycoprotein metabolic process 0.007116 Highly Informative Inherited
Biological Process (BP) wound healing 0.996 Highly Informative Inherited
Biological Process (BP) positive regulation of proteolysis 0.01616 Highly Informative Inherited
Biological Process (BP) regulation of lipid storage 0.0511 Highly Informative Inherited
Biological Process (BP) muscle system process 0.4337 Highly Informative Inherited
Biological Process (BP) regulation of cysteine-type endopeptidase activity 0.7701 Highly Informative Inherited
Biological Process (BP) acylglycerol metabolic process 0.003515 Highly Informative Inherited
Biological Process (BP) negative regulation of transferase activity 0.007698 Highly Informative Inherited
Biological Process (BP) negative regulation of protein modification process 0.6779 Highly Informative Inherited
Biological Process (BP) negative regulation of phosphate metabolic process 0.9255 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 1 Highly Informative Inherited
Biological Process (BP) tube morphogenesis 1 Highly Informative Inherited
Biological Process (BP) pattern specification process 1 Highly Informative Inherited
Biological Process (BP) positive regulation of adaptive immune response based on somatic recombination of immune receptors b 1 Highly Informative Inherited
Biological Process (BP) protein maturation 0.005987 Highly Informative Inherited
Biological Process (BP) inflammatory response 0.03285 Highly Informative Inherited
Biological Process (BP) angiogenesis 0.004225 Highly Informative Inherited
Biological Process (BP) regulation of epithelial cell proliferation 0.03252 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 0.9831 Highly Informative Inherited
Biological Process (BP) regulation of cell killing 0.001561 Highly Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.0071 Highly Informative Inherited
Biological Process (BP) establishment of organelle localization 0.942 Highly Informative Inherited
Biological Process (BP) microtubule cytoskeleton organization 0.991 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) transferase activity 0.00000000798 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) structural molecule activity 0 Moderately Informative Direct
Molecular Function (MF) protein binding 0 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 0.0000000001048 Moderately Informative Direct
Molecular Function (MF) anion binding 0.0001655 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.3396 Moderately Informative Inherited
Molecular Function (MF) molecular function regulator 1 Moderately Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0 Informative Direct
Molecular Function (MF) signal transducer activity 0 Informative Direct
Molecular Function (MF) sulfur compound binding 0 Informative Direct
Molecular Function (MF) identical protein binding 0 Informative Direct
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) phosphoric ester hydrolase activity 0 Informative Direct
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) protein dimerization activity 0.00000000001825 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 1 Informative Inherited
Molecular Function (MF) amide binding 0.007695 Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 1 Informative Inherited
Molecular Function (MF) macromolecular complex binding 0.867 Informative Inherited
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) transmembrane signaling receptor activity 0 Highly Informative Direct
Molecular Function (MF) heparin binding 0 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0 Highly Informative Direct
Molecular Function (MF) phosphoprotein phosphatase activity 0 Highly Informative Direct
Molecular Function (MF) hormone binding 0.000000000481 Highly Informative Direct
Molecular Function (MF) peptide binding 0.0000005758 Highly Informative Direct
Molecular Function (MF) protein homodimerization activity 0.00006336 Highly Informative Direct
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0.0003765 Highly Informative Direct
Molecular Function (MF) UDP-glycosyltransferase activity 0.01338 Highly Informative Inherited
Molecular Function (MF) transferase activity, transferring hexosyl groups 0.1491 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) intrinsic component of membrane 0 Moderately Informative Direct
Cellular Component (CC) vesicle 0.000137 Moderately Informative Direct
Cellular Component (CC) whole membrane 1 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 1 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.2887 Moderately Informative Inherited
Cellular Component (CC) cell surface 0 Informative Direct
Cellular Component (CC) cell junction 0 Informative Direct
Cellular Component (CC) neuron projection 0 Informative Direct
Cellular Component (CC) synapse 0.00000000000003546 Informative Direct
Cellular Component (CC) apical part of cell 0.0000000002783 Informative Direct
Cellular Component (CC) cell projection part 0.000000001635 Informative Direct
Cellular Component (CC) site of polarized growth 0.00000001563 Informative Direct
Cellular Component (CC) extracellular organelle 0.00001028 Informative Direct
Cellular Component (CC) extracellular space 1 Informative Inherited
Cellular Component (CC) endosome 0.001019 Informative Inherited
Cellular Component (CC) cytoplasmic vesicle part 0.1226 Informative Inherited
Cellular Component (CC) actin cytoskeleton 1 Informative Inherited
Cellular Component (CC) extracellular matrix 0 Highly Informative Direct
Cellular Component (CC) contractile fiber part 0 Highly Informative Direct
Cellular Component (CC) intrinsic component of plasma membrane 0 Highly Informative Direct
Cellular Component (CC) neuronal cell body 0.00000000827 Highly Informative Direct
Cellular Component (CC) receptor complex 0.00000004251 Highly Informative Direct
Cellular Component (CC) dendrite 0.0000009748 Highly Informative Direct
Cellular Component (CC) myofibril 0.0001699 Highly Informative Direct
Cellular Component (CC) lateral plasma membrane 0.0007725 Highly Informative Direct
Cellular Component (CC) growth cone 0.009241 Highly Informative Inherited
Cellular Component (CC) endosome membrane 0.002625 Highly Informative Inherited
Cellular Component (CC) early endosome 0.004544 Highly Informative Inherited
Cellular Component (CC) anchoring junction 0.01353 Highly Informative Inherited
Cellular Component (CC) cell-substrate junction 0.5988 Highly Informative Inherited
Cellular Component (CC) cell-cell junction 0.5126 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0.000000000000007826Least InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl0.00000000004277Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.1816Moderately InformativeInherited
Enzyme Commission (EC)Receptor protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0InformativeDirect
Enzyme Commission (EC)Chitinase0.0002219Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.523Least InformativeInherited
Disease Ontology (DO)urinary system disease0.2225Moderately InformativeInherited
Disease Ontology (DO)neurodegenerative disease0.4791Moderately InformativeInherited
Disease Ontology (DO)disease by infectious agent0.5408Moderately InformativeInherited
Disease Ontology (DO)primary bacterial infectious disease0.7074InformativeInherited
Disease Ontology (DO)acute kidney failure0.000001788Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Functional respiratory abnormality0.7117Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal pattern of respiration0.1252InformativeInherited
Phenotypic Abnormality (PA)Nocturnal hypoventilation0.0004965Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.0146Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.3301Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.6512Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.679Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.912Least InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.003341Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.0247Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.07374Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development0.1602Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.2592Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.4087Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system physiology0.7337Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.8101Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal circulating cytokine level0.000003535InformativeDirect
Mammalian Phenotype (MP)autoimmune response0.000126InformativeDirect
Mammalian Phenotype (MP)abnormal cell differentiation0.002802InformativeInherited
Mammalian Phenotype (MP)abnormal heart layer morphology0.1205InformativeInherited
Mammalian Phenotype (MP)abnormal female reproductive system physiology0.2005InformativeInherited
Mammalian Phenotype (MP)abnormal white adipose tissue morphology0.3833InformativeInherited
Mammalian Phenotype (MP)abnormal interferon level0.4754InformativeInherited
Mammalian Phenotype (MP)abnormal spermatogenesis0.6159InformativeInherited
Mammalian Phenotype (MP)abnormal adipose tissue amount0.7911InformativeInherited
Mammalian Phenotype (MP)increased apoptosis0.8122InformativeInherited
Mammalian Phenotype (MP)abnormal axon guidance0.0004504Highly InformativeDirect
Mammalian Phenotype (MP)abnormal spermiogenesis0.08998Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell morphology variant0.0002164Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.0004994Least InformativeDirect
Worm Phenotype (WP)cell development variant0.003003Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.00642Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.0304Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.1773Least InformativeInherited
Worm Phenotype (WP)nervous system morphology variant0.0007192Moderately InformativeDirect
Worm Phenotype (WP)cell homeostasis metabolism variant0.01122Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.01186Moderately InformativeInherited
Worm Phenotype (WP)reproductive system development variant0.0808Moderately InformativeInherited
Worm Phenotype (WP)organism stress response variant0.829Moderately InformativeInherited
Worm Phenotype (WP)cell component morphology variant1Moderately InformativeInherited
Worm Phenotype (WP)locomotion reduced0.000004127InformativeDirect
Worm Phenotype (WP)body posture variant0.0002911InformativeDirect
Worm Phenotype (WP)growth rate variant0.0008648InformativeDirect
Worm Phenotype (WP)neuronal outgrowth variant0.001112InformativeInherited
Worm Phenotype (WP)locomotor coordination variant0.001953InformativeInherited
Worm Phenotype (WP)forward locomotion variant0.02577InformativeInherited
Worm Phenotype (WP)protein metabolism variant0.03179InformativeInherited
Worm Phenotype (WP)anchor cell invasion variant0.00000000003158Highly InformativeDirect
Worm Phenotype (WP)muscle arm development defective0.000000004366Highly InformativeDirect
Worm Phenotype (WP)axon morphology variant0.00000002365Highly InformativeDirect
Worm Phenotype (WP)forward locomotion decreased0.00003786Highly InformativeDirect
Worm Phenotype (WP)organism temperature response variant0.0007425Highly InformativeDirect
Worm Phenotype (WP)mitochondria morphology variant0.0007669Highly InformativeDirect
Worm Phenotype (WP)loss of left right asymmetry0.08979Highly InformativeInherited
Worm Phenotype (WP)axon development variant0.1739Highly InformativeInherited
Worm Phenotype (WP)neuronal cell fate specification variant0.1849Highly InformativeInherited
Worm Phenotype (WP)path curvature variant0.7305Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)anatomical group0.00008641Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0.0001594Least InformativeDirect
Fly Anatomy (FA)nervous system0.01413Least InformativeInherited
Fly Anatomy (FA)larva0.01665Least InformativeInherited
Fly Anatomy (FA)adult0.03404Least InformativeInherited
Fly Anatomy (FA)cell0.3991Least InformativeInherited
Fly Anatomy (FA)integumentary system0.5494Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.00000001609Moderately InformativeDirect
Fly Anatomy (FA)central nervous system0.01105Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.02018Moderately InformativeInherited
Fly Anatomy (FA)late embryo0.02941Moderately InformativeInherited
Fly Anatomy (FA)cell cluster organ0.03807Moderately InformativeInherited
Fly Anatomy (FA)sense organ0.07873Moderately InformativeInherited
Fly Anatomy (FA)adult segment0.1929Moderately InformativeInherited
Fly Anatomy (FA)neuron0.2049Moderately InformativeInherited
Fly Anatomy (FA)adult thorax0.8604Moderately InformativeInherited
Fly Anatomy (FA)tagmatic subdivision of integument0.9125Moderately InformativeInherited
Fly Anatomy (FA)appendage0.9767Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.9961Moderately InformativeInherited
Fly Anatomy (FA)thoracic segment1Moderately InformativeInherited
Fly Anatomy (FA)larval abdomen0.000007927InformativeDirect
Fly Anatomy (FA)chemosensory system0.01107InformativeInherited
Fly Anatomy (FA)chaeta0.03208InformativeInherited
Fly Anatomy (FA)leg0.1794InformativeInherited
Fly Anatomy (FA)tract0.3226InformativeInherited
Fly Anatomy (FA)thoracic T1 neuron0.00004905Highly InformativeDirect
Fly Anatomy (FA)prothoracic leg taste bristle0.000363Highly InformativeDirect
Fly Anatomy (FA)chemosensory neuron0.007705Highly InformativeInherited
Fly Anatomy (FA)eo neuron0.0741Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)multi-tissue structure0.01921Least InformativeInherited
Zebrafish Anatomy (ZA)compound organ0.1081Least InformativeInherited
Zebrafish Anatomy (ZA)nervous system0.2495Least InformativeInherited
Zebrafish Anatomy (ZA)central nervous system0.2052Moderately InformativeInherited
Zebrafish Anatomy (ZA)forebrain0.02169InformativeInherited
Zebrafish Anatomy (ZA)medial longitudinal fasciculus0.0002008Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system0.9903Least InformativeInherited
Xenopus ANatomical entity (XAN)head1Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue1Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)sensory system1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)retina0.02907InformativeInherited
Xenopus ANatomical entity (XAN)retinal ganglion cell layer0.0008457Highly InformativeDirect
Xenopus DEvelopment stage (XDE)NF stage0.00000002535Least InformativeDirect
Xenopus DEvelopment stage (XDE)embryonic stage0.0000008342Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases0.0000001003Least InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosylases0.00001156Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.1564Moderately InformativeInherited
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0Highly InformativeDirect
Enzyme Commission (EC)Chitinase0.0006555Highly InformativeDirect

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)antineoplastic and immunomodulating agents0.0000108Least InformativeDirect
Drugbank ATC_code (DB)systemic hormonal preparations, excl. sex hormones and insulins0.001069Moderately InformativeInherited
Drugbank ATC_code (DB)immunosuppressants0.6127Moderately InformativeInherited
Drugbank ATC_code (DB)pituitary and hypothalamic hormones and analogues0.00006602InformativeDirect
Drugbank ATC_code (DB)interleukin inhibitors0.0009222InformativeDirect
Drugbank ATC_code (DB)immunostimulants0.00000000158Highly InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation0Moderately InformativeDirect
Biological processCarbohydrate metabolism0.1596Moderately InformativeInherited
Biological processAngiogenesis0InformativeDirect
Biological processCell adhesion0InformativeDirect
Biological processEndocytosis0InformativeDirect
Biological processNeurogenesis0InformativeDirect
Biological processHemostasis0.000002952InformativeDirect
Biological processPolysaccharide degradation0.00005369InformativeDirect
Biological processChemotaxis0.0004818InformativeDirect
Biological processSensory transduction0.03848InformativeInherited
Biological processAcute phase0.00000000000191Highly InformativeDirect
Biological processNotch signaling pathway0.0000000149Highly InformativeDirect
Biological processBlood coagulation0.000002806Highly InformativeDirect
Biological processVision0.00003136Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentEndosome0.000000002341Moderately InformativeDirect
Cellular componentCytoskeleton0.0000002202Moderately InformativeDirect
Cellular componentExtracellular matrix0InformativeDirect
Cellular componentGPI-anchor0InformativeDirect
Coding sequence diversityAlternative splicing0.000006672Least InformativeDirect
DiseaseDisease mutation0.000004711Least InformativeDirect
DomainRepeat0Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
DomainImmunoglobulin domain0InformativeDirect
DomainEGF-like domain0.000000000000001854InformativeDirect
DomainLeucine-rich repeat0.000000000000009404InformativeDirect
DomainCollagen0.000000006266Highly InformativeDirect
Molecular functionHeparin-binding0InformativeDirect
Molecular functionCalmodulin-binding0.000002659InformativeDirect
Molecular functionActin-binding0.00002138InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationProtease1Moderately InformativeInherited
Post-translational modificationProtein phosphatase0InformativeDirect
Post-translational modificationGlycosidase0.0006892InformativeDirect
Post-translational modificationMetalloprotease0.0009882InformativeDirect
Post-translational modificationMuscle protein0Highly InformativeDirect
Post-translational modificationTyrosine-protein kinase0Highly InformativeDirect
Post-translational modificationCytokine0.00000000000000267Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationProteoglycan0.0008724InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism9.126e-16Least InformativeDirect
UniPathway (UP)protein glycosylation0.00000001025InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR008957 SSF49265 Protein matches
Abstract

Fibronectin is composed of three repeating structural motifs, of which one is the FnIII module. The three modules form a linear sequence of multiple tandem copies connected by short linker peptides. The secondary structure of the FnIII10 module, which is the only fibronectin module to possess an integrin binding RGD motif, consists of two beta-sheets containing the antiparallel beta-strands ABE and DCFG, respectively, which fold up to form a beta-sandwich. The RGD sequence is located in the loop connecting the beta-strands [PubMed9990027].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 111 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Fibronectin type III domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 111 hidden Markov models representing the Fibronectin type III superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]