SUPERFAMILY 1.75 HMM library and genome assignments server


Fibronectin type III superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Immunoglobulin-like beta-sandwich [ 48725] (28)
Superfamily:   Fibronectin type III [ 49265]
Families:   Fibronectin type III [ 49266] (44)


Superfamily statistics
Genomes (1,373) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 61,851 69,426 172
Proteins 25,450 33,746 117


Functional annotation
General category Processes_EC
Detailed category Cell adhesion

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism cellular process0.0017850Least InformativeInherited
Biological Process (BP)multicellular organismal process0.001660Least InformativeInherited
Biological Process (BP)developmental process0.0037630Least InformativeInherited
Biological Process (BP)regulation of cellular process0.34590.1945Least InformativeInherited
Biological Process (BP)localization0.037081.5e-08Least InformativeInherited
Biological Process (BP)response to stimulus0.016870Least InformativeInherited
Biological Process (BP)reproduction1.537e-050.0004604Moderately InformativeDirect
Biological Process (BP)cell differentiation6.642e-052.454e-09Moderately InformativeDirect
Biological Process (BP)regulation of multicellular organismal process0.00081250Moderately InformativeDirect
Biological Process (BP)tissue development2.703e-061Moderately InformativeInherited
Biological Process (BP)organ development9.96e-050.004329Moderately InformativeInherited
Biological Process (BP)single-organism developmental process0.042230Moderately InformativeInherited
Biological Process (BP)response to endogenous stimulus0.010771Moderately InformativeInherited
Biological Process (BP)response to organic substance0.0011781Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.0054250.7368Moderately InformativeInherited
Biological Process (BP)signal transduction0.10850Moderately InformativeInherited
Biological Process (BP)response to cytokine stimulus2.728e-070InformativeDirect
Biological Process (BP)secretion2.09e-054.82e-08InformativeDirect
Biological Process (BP)regulation of body fluid levels6.125e-051.53e-14InformativeDirect
Biological Process (BP)growth0.00034750InformativeDirect
Biological Process (BP)gland development2.114e-060.6137InformativeInherited
Biological Process (BP)epithelium development9.795e-080.2643InformativeInherited
Biological Process (BP)cellular response to endogenous stimulus0.0001380.01711InformativeInherited
Biological Process (BP)response to hormone stimulus0.034381InformativeInherited
Biological Process (BP)reproductive system development1.853e-081InformativeInherited
Biological Process (BP)developmental process involved in reproduction4.115e-071InformativeInherited
Biological Process (BP)multicellular organismal reproductive process0.031750.001383InformativeInherited
Biological Process (BP)intracellular signal transduction0.033391InformativeInherited
Biological Process (BP)cytokine-mediated signaling pathway2.483e-090Highly InformativeDirect
Biological Process (BP)mammary gland alveolus development4.779e-080.000547Highly InformativeDirect
Biological Process (BP)regulation of cell adhesion1.571e-060Highly InformativeDirect
Biological Process (BP)lactation4.503e-050.0001525Highly InformativeDirect
Biological Process (BP)developmental growth0.00026456.106e-11Highly InformativeDirect
Biological Process (BP)mammary gland epithelium development0.00039530.0006117Highly InformativeDirect
Biological Process (BP)hormone-mediated signaling pathway5.84e-051Highly InformativeInherited
Molecular Function (MF)binding0.013260Least InformativeInherited
Molecular Function (MF)protein binding0.00014130Moderately InformativeDirect
Molecular Function (MF)receptor activity2.897e-080InformativeDirect
Molecular Function (MF)molecular transducer activity6.402e-080InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) localization 1.5e-08 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) protein metabolic process 0 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 1.625e-06 Least Informative Direct
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.1945 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) reproduction 0.0004604 Moderately Informative Direct
Biological Process (BP) cell differentiation 2.454e-09 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 1.677e-12 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 0 Moderately Informative Direct
Biological Process (BP) signal transduction 0 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 0 Moderately Informative Direct
Biological Process (BP) regulation of signaling 0 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) nervous system development 0 Moderately Informative Direct
Biological Process (BP) immune system process 1.843e-11 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 3.091e-10 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 8.328e-05 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.000252 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 0.0008945 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) system process 0.5743 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.1151 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organ development 0.004329 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.006219 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.7368 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.9415 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.426 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.5484 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.9745 Moderately Informative Inherited
Biological Process (BP) response to cytokine stimulus 0 Informative Direct
Biological Process (BP) secretion 4.82e-08 Informative Direct
Biological Process (BP) regulation of body fluid levels 1.53e-14 Informative Direct
Biological Process (BP) growth 0 Informative Direct
Biological Process (BP) cellular component movement 0 Informative Direct
Biological Process (BP) protein phosphorylation 0 Informative Direct
Biological Process (BP) central nervous system development 0 Informative Direct
Biological Process (BP) biological adhesion 0 Informative Direct
Biological Process (BP) regulation of apoptotic process 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) response to external stimulus 0 Informative Direct
Biological Process (BP) cell projection organization 0 Informative Direct
Biological Process (BP) localization of cell 0 Informative Direct
Biological Process (BP) response to wounding 0 Informative Direct
Biological Process (BP) generation of neurons 0 Informative Direct
Biological Process (BP) dephosphorylation 0 Informative Direct
Biological Process (BP) cellular component morphogenesis 0 Informative Direct
Biological Process (BP) positive regulation of developmental process 1.743e-12 Informative Direct
Biological Process (BP) vesicle-mediated transport 1.568e-11 Informative Direct
Biological Process (BP) blood circulation 1.476e-09 Informative Direct
Biological Process (BP) regulation of cellular component movement 3.059e-08 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 7.346e-08 Informative Direct
Biological Process (BP) regulation of locomotion 7.38e-08 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 2.664e-06 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 4.191e-06 Informative Direct
Biological Process (BP) cell activation 7.499e-06 Informative Direct
Biological Process (BP) regulation of cell proliferation 1.03e-05 Informative Direct
Biological Process (BP) regulation of hydrolase activity 2.151e-05 Informative Direct
Biological Process (BP) defense response 2.947e-05 Informative Direct
Biological Process (BP) negative regulation of signaling 5.049e-05 Informative Direct
Biological Process (BP) regulation of cell development 0.0001048 Informative Direct
Biological Process (BP) cytoskeleton organization 0.0001142 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0.0002289 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.0002606 Informative Direct
Biological Process (BP) apoptotic process 0.0004562 Informative Direct
Biological Process (BP) negative regulation of cell death 0.0008202 Informative Direct
Biological Process (BP) epithelium development 0.2643 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.01711 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 1 Informative Inherited
Biological Process (BP) response to organic nitrogen 1 Informative Inherited
Biological Process (BP) response to hormone stimulus 1 Informative Inherited
Biological Process (BP) regulation of cell cycle process 1 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.3218 Informative Inherited
Biological Process (BP) anatomical structure homeostasis 0.00845 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.0618 Informative Inherited
Biological Process (BP) regulation of growth 0.91 Informative Inherited
Biological Process (BP) tissue morphogenesis 1 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 1 Informative Inherited
Biological Process (BP) gland development 0.6137 Informative Inherited
Biological Process (BP) metal ion transport 1 Informative Inherited
Biological Process (BP) metal ion homeostasis 0.5927 Informative Inherited
Biological Process (BP) cytoplasmic transport 1 Informative Inherited
Biological Process (BP) cellular cation homeostasis 1 Informative Inherited
Biological Process (BP) sensory organ development 0.9841 Informative Inherited
Biological Process (BP) regulation of organelle organization 1 Informative Inherited
Biological Process (BP) protein oligomerization 0.144 Informative Inherited
Biological Process (BP) synaptic transmission 1 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.002256 Informative Inherited
Biological Process (BP) regulation of response to stress 1 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.04783 Informative Inherited
Biological Process (BP) organ morphogenesis 0.4662 Informative Inherited
Biological Process (BP) regulation of system process 0.7779 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.03617 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.4296 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.4149 Informative Inherited
Biological Process (BP) cellular membrane organization 1 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 1 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.7235 Informative Inherited
Biological Process (BP) regulation of kinase activity 1 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.1709 Informative Inherited
Biological Process (BP) immune response 1 Informative Inherited
Biological Process (BP) immune effector process 0.1372 Informative Inherited
Biological Process (BP) cell proliferation 0.07332 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.7551 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 1 Informative Inherited
Biological Process (BP) reproductive system development 1 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) actin filament-based process 0.02932 Informative Inherited
Biological Process (BP) muscle structure development 0.01422 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.1085 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.01198 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.1692 Informative Inherited
Biological Process (BP) muscle tissue development 0.0476 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.01239 Informative Inherited
Biological Process (BP) embryonic morphogenesis 1 Informative Inherited
Biological Process (BP) response to other organism 0.1546 Informative Inherited
Biological Process (BP) sexual reproduction 0.1094 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.001383 Informative Inherited
Biological Process (BP) single organism reproductive process 0.4302 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.1941 Informative Inherited
Biological Process (BP) muscle system process 0.001736 Informative Inherited
Biological Process (BP) glycerolipid metabolic process 0.7857 Informative Inherited
Biological Process (BP) pigment metabolic process 0.04452 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 1 Informative Inherited
Biological Process (BP) regulation of immune effector process 0.002962 Informative Inherited
Biological Process (BP) regulation of immune response 0.9428 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.9946 Informative Inherited
Biological Process (BP) cytokine-mediated signaling pathway 0 Highly Informative Direct
Biological Process (BP) mammary gland alveolus development 0.000547 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 0 Highly Informative Direct
Biological Process (BP) lactation 0.0001525 Highly Informative Direct
Biological Process (BP) developmental growth 6.106e-11 Highly Informative Direct
Biological Process (BP) mammary gland epithelium development 0.0006117 Highly Informative Direct
Biological Process (BP) phagocytosis 0 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0 Highly Informative Direct
Biological Process (BP) chemotaxis 0 Highly Informative Direct
Biological Process (BP) peptidyl-tyrosine phosphorylation 0 Highly Informative Direct
Biological Process (BP) negative regulation of immune system process 0 Highly Informative Direct
Biological Process (BP) cell adhesion 0 Highly Informative Direct
Biological Process (BP) protein dephosphorylation 0 Highly Informative Direct
Biological Process (BP) axonogenesis 0 Highly Informative Direct
Biological Process (BP) cell growth 0 Highly Informative Direct
Biological Process (BP) regulation of cell projection organization 1.03e-11 Highly Informative Direct
Biological Process (BP) positive regulation of peptidase activity 2.428e-11 Highly Informative Direct
Biological Process (BP) actomyosin structure organization 6.045e-11 Highly Informative Direct
Biological Process (BP) regulation of lymphocyte mediated immunity 7.634e-10 Highly Informative Direct
Biological Process (BP) spermatogenesis 8.199e-10 Highly Informative Direct
Biological Process (BP) regulation of neuron apoptotic process 1.829e-09 Highly Informative Direct
Biological Process (BP) negative regulation of neuron death 3.89e-09 Highly Informative Direct
Biological Process (BP) positive regulation of protein kinase B signaling cascade 9.911e-09 Highly Informative Direct
Biological Process (BP) negative regulation of locomotion 1.116e-08 Highly Informative Direct
Biological Process (BP) regulation of mononuclear cell proliferation 1.378e-08 Highly Informative Direct
Biological Process (BP) negative regulation of response to external stimulus 2.212e-08 Highly Informative Direct
Biological Process (BP) negative regulation of cellular component movement 2.99e-07 Highly Informative Direct
Biological Process (BP) regulation of purine nucleotide catabolic process 3.02e-07 Highly Informative Direct
Biological Process (BP) eye morphogenesis 3.47e-07 Highly Informative Direct
Biological Process (BP) regulation of angiogenesis 3.897e-07 Highly Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 6.833e-07 Highly Informative Direct
Biological Process (BP) protein processing 2.241e-06 Highly Informative Direct
Biological Process (BP) regulation of cell killing 4.769e-06 Highly Informative Direct
Biological Process (BP) positive regulation of cell differentiation 5.114e-06 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 5.888e-06 Highly Informative Direct
Biological Process (BP) coagulation 5.922e-06 Highly Informative Direct
Biological Process (BP) positive regulation of cell activation 4.121e-05 Highly Informative Direct
Biological Process (BP) response to virus 5.413e-05 Highly Informative Direct
Biological Process (BP) response to ethanol 0.0001593 Highly Informative Direct
Biological Process (BP) regulation of peptidyl-tyrosine phosphorylation 0.0001989 Highly Informative Direct
Biological Process (BP) protein tetramerization 0.0002627 Highly Informative Direct
Biological Process (BP) regulation of cell cycle arrest 0.0003441 Highly Informative Direct
Biological Process (BP) regulation of inflammatory response 0.0006434 Highly Informative Direct
Biological Process (BP) regulation of blood pressure 0.0006816 Highly Informative Direct
Biological Process (BP) regulation of actin cytoskeleton organization 0.0008734 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 0.0009325 Highly Informative Direct
Biological Process (BP) kidney development 0.1391 Highly Informative Inherited
Biological Process (BP) cellular response to peptide hormone stimulus 0.02662 Highly Informative Inherited
Biological Process (BP) positive regulation of cell cycle process 0.8828 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.3847 Highly Informative Inherited
Biological Process (BP) wound healing 0.008223 Highly Informative Inherited
Biological Process (BP) hemostasis 1 Highly Informative Inherited
Biological Process (BP) actin filament-based movement 0.9377 Highly Informative Inherited
Biological Process (BP) regulation of cellular component size 0.009945 Highly Informative Inherited
Biological Process (BP) calcium ion transport 0.4676 Highly Informative Inherited
Biological Process (BP) cellular calcium ion homeostasis 0.1958 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.8599 Highly Informative Inherited
Biological Process (BP) regulation of ion homeostasis 0.2397 Highly Informative Inherited
Biological Process (BP) immune response-regulating signaling pathway 1 Highly Informative Inherited
Biological Process (BP) activation of immune response 1 Highly Informative Inherited
Biological Process (BP) negative regulation of cell development 0.05822 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis 0.003466 Highly Informative Inherited
Biological Process (BP) regulation of neuron differentiation 0.01727 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 0.4955 Highly Informative Inherited
Biological Process (BP) regulation of neurological system process 1 Highly Informative Inherited
Biological Process (BP) cell fate commitment 1 Highly Informative Inherited
Biological Process (BP) regulation of innate immune response 0.1452 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 0.4596 Highly Informative Inherited
Biological Process (BP) regulation of lymphocyte activation 0.02603 Highly Informative Inherited
Biological Process (BP) multicellular organismal metabolic process 0.001066 Highly Informative Inherited
Biological Process (BP) positive regulation of lipid metabolic process 0.03293 Highly Informative Inherited
Biological Process (BP) negative regulation of apoptotic process 0.01272 Highly Informative Inherited
Biological Process (BP) regulation of cysteine-type endopeptidase activity involved in apoptotic process 0.001075 Highly Informative Inherited
Biological Process (BP) leukocyte proliferation 0.00405 Highly Informative Inherited
Biological Process (BP) B cell activation 0.8411 Highly Informative Inherited
Biological Process (BP) hormone-mediated signaling pathway 1 Highly Informative Inherited
Biological Process (BP) pattern specification process 1 Highly Informative Inherited
Biological Process (BP) innate immune response 1 Highly Informative Inherited
Biological Process (BP) negative regulation of signal transduction 0.4313 Highly Informative Inherited
Biological Process (BP) regulation of Ras protein signal transduction 0.5272 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.01527 Highly Informative Inherited
Biological Process (BP) development of primary female sexual characteristics 1 Highly Informative Inherited
Biological Process (BP) cellular component assembly involved in morphogenesis 0.006423 Highly Informative Inherited
Biological Process (BP) glycosaminoglycan metabolic process 1 Highly Informative Inherited
Biological Process (BP) cell projection assembly 0.7152 Highly Informative Inherited
Biological Process (BP) telencephalon development 0.003271 Highly Informative Inherited
Biological Process (BP) peptidyl-serine modification 1 Highly Informative Inherited
Biological Process (BP) muscle organ development 1 Highly Informative Inherited
Biological Process (BP) retina development in camera-type eye 0.2131 Highly Informative Inherited
Biological Process (BP) acylglycerol metabolic process 0.002756 Highly Informative Inherited
Biological Process (BP) amino sugar metabolic process 0.01011 Highly Informative Inherited
Biological Process (BP) aminoglycan catabolic process 0.01033 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.01106 Highly Informative Inherited
Biological Process (BP) positive regulation of adaptive immune response 0.007518 Highly Informative Inherited
Biological Process (BP) leukocyte migration 0.001484 Highly Informative Inherited
Biological Process (BP) inflammatory response 0.04428 Highly Informative Inherited
Biological Process (BP) regulation of adaptive immune response based on somatic recombination of immune receptors built from 0.5264 Highly Informative Inherited
Biological Process (BP) lymphocyte differentiation 0.09611 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 0.05519 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) transferase activity 2.676e-14 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) protein binding 0 Moderately Informative Direct
Molecular Function (MF) structural molecule activity 0 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 1.976e-13 Moderately Informative Direct
Molecular Function (MF) anion binding 7.152e-07 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 0.7874 Moderately Informative Inherited
Molecular Function (MF) receptor activity 0 Informative Direct
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) protein dimerization activity 0 Informative Direct
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0 Informative Direct
Molecular Function (MF) phosphoric ester hydrolase activity 0 Informative Direct
Molecular Function (MF) peptidase regulator activity 0.0001278 Informative Direct
Molecular Function (MF) carboxylic acid binding 0.9207 Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 1 Informative Inherited
Molecular Function (MF) enzyme binding 1 Informative Inherited
Molecular Function (MF) enzyme activator activity 0.01777 Informative Inherited
Molecular Function (MF) receptor binding 0.9294 Informative Inherited
Molecular Function (MF) sulfur compound binding 0 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0 Highly Informative Direct
Molecular Function (MF) phosphoprotein phosphatase activity 0 Highly Informative Direct
Molecular Function (MF) hormone binding 1.049e-07 Highly Informative Direct
Molecular Function (MF) peptide binding 4.01e-05 Highly Informative Direct
Molecular Function (MF) glycosaminoglycan binding 0.03036 Highly Informative Inherited
Molecular Function (MF) protein complex binding 0.4875 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.6615 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) extracellular region 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 1.581e-08 Moderately Informative Direct
Cellular Component (CC) organelle membrane 1 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.03077 Moderately Informative Inherited
Cellular Component (CC) extracellular matrix 0 Informative Direct
Cellular Component (CC) neuron part 0 Informative Direct
Cellular Component (CC) contractile fiber part 0 Informative Direct
Cellular Component (CC) cell junction 0 Informative Direct
Cellular Component (CC) intrinsic to plasma membrane 0 Informative Direct
Cellular Component (CC) cell surface 0 Informative Direct
Cellular Component (CC) cell projection part 1.494e-14 Informative Direct
Cellular Component (CC) cell leading edge 4.285e-09 Informative Direct
Cellular Component (CC) endosome 2.463e-05 Informative Direct
Cellular Component (CC) integral to membrane 0.000628 Informative Direct
Cellular Component (CC) actin cytoskeleton 1 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) proteinaceous extracellular matrix 0 Highly Informative Direct
Cellular Component (CC) cell body 0 Highly Informative Direct
Cellular Component (CC) integral to plasma membrane 0 Highly Informative Direct
Cellular Component (CC) extracellular matrix part 0 Highly Informative Direct
Cellular Component (CC) adherens junction 2.351e-14 Highly Informative Direct
Cellular Component (CC) receptor complex 7.865e-07 Highly Informative Direct
Cellular Component (CC) dendrite 6.607e-06 Highly Informative Direct
Cellular Component (CC) endosomal part 7.554e-05 Highly Informative Direct
Cellular Component (CC) myosin complex 0.0003064 Highly Informative Direct
Cellular Component (CC) microtubule associated complex 0.0004959 Highly Informative Direct
Cellular Component (CC) cell-cell junction 1 Highly Informative Inherited
Cellular Component (CC) sarcomere 0.02013 Highly Informative Inherited
Cellular Component (CC) cell-substrate junction 0.02505 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds7.826e-15Least InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl4.277e-11Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.1816Moderately InformativeInherited
Enzyme Commission (EC)Receptor protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0InformativeDirect
Enzyme Commission (EC)Chitinase0.0002219Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)kidney disease0.05807Moderately InformativeInherited
Disease Ontology (DO)disease by infectious agent0.5986Moderately InformativeInherited
Disease Ontology (DO)kidney failure0.04019InformativeInherited
Disease Ontology (DO)primary bacterial infectious disease0.6924InformativeInherited
Disease Ontology (DO)acute kidney failure2.277e-06Highly InformativeDirect
Disease Ontology (DO)leprosy0.0331Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the integument0.4558Least InformativeInherited
Phenotypic Abnormality (PA)Generalized abnormality of skin0.3845Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin morphology0.5149InformativeInherited
Phenotypic Abnormality (PA)Salmonella osteomyelitis9.218e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Lichenification0.0009373Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.05393Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.2358Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.2818Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.7917Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.9313Least InformativeInherited
Mammalian Phenotype (MP)abnormal cell differentiation0.0001202Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal protein level0.00152Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.00995Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.273Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.4505Moderately InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to infection0.4741Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.8314Moderately InformativeInherited
Mammalian Phenotype (MP)embryogenesis phenotype0.9321Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal circulating cytokine level4.474e-05InformativeDirect
Mammalian Phenotype (MP)abnormal internal female genitalia morphology0.09797InformativeInherited
Mammalian Phenotype (MP)abnormal neuron differentiation0.1451InformativeInherited
Mammalian Phenotype (MP)abnormal extraembryonic tissue morphology0.21InformativeInherited
Mammalian Phenotype (MP)abnormal interferon level0.3387InformativeInherited
Mammalian Phenotype (MP)abnormal eye physiology0.344InformativeInherited
Mammalian Phenotype (MP)abnormal spermatogenesis0.7044InformativeInherited
Mammalian Phenotype (MP)increased susceptibility to infection0.8426InformativeInherited
Mammalian Phenotype (MP)decreased Sertoli cell phagocytosis2.692e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal axon guidance0.0004713Highly InformativeDirect
Mammalian Phenotype (MP)abnormal uterus morphology0.002512Highly InformativeInherited
Mammalian Phenotype (MP)abnormal vagina morphology0.02681Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.02119Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.0997Least InformativeInherited
Worm Phenotype (WP)growth variant0.7352Least InformativeInherited
Worm Phenotype (WP)organ system development variant3.815e-07Moderately InformativeDirect
Worm Phenotype (WP)cell homeostasis metabolism variant0.007356Moderately InformativeInherited
Worm Phenotype (WP)locomotion variant0.00995Moderately InformativeInherited
Worm Phenotype (WP)anchor cell invasion variant1.004e-10InformativeDirect
Worm Phenotype (WP)neuron development variant5.758e-07InformativeDirect
Worm Phenotype (WP)cell migration variant0.0005568InformativeDirect
Worm Phenotype (WP)muscle cell morphology variant0.001963InformativeInherited
Worm Phenotype (WP)activity level variant0.01276InformativeInherited
Worm Phenotype (WP)locomotor coordination variant0.01636InformativeInherited
Worm Phenotype (WP)protein metabolism variant0.04595InformativeInherited
Worm Phenotype (WP)organism stress response variant0.647InformativeInherited
Worm Phenotype (WP)muscle arm development defective7.638e-09Highly InformativeDirect
Worm Phenotype (WP)axon morphology variant2.387e-08Highly InformativeDirect
Worm Phenotype (WP)myopodia present5.88e-06Highly InformativeDirect
Worm Phenotype (WP)protein degradation variant0.0001454Highly InformativeDirect
Worm Phenotype (WP)roller0.0001569Highly InformativeDirect
Worm Phenotype (WP)growth rate variant0.0008138Highly InformativeDirect
Worm Phenotype (WP)loss of asymmetry ASE0.0009604Highly InformativeDirect
Worm Phenotype (WP)axon development variant0.5179Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)cell adhesion defective2.079e-05Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system subdivision0.0003628Least InformativeDirect
Fly Anatomy (FA)organ system0.001916Least InformativeInherited
Fly Anatomy (FA)larva0.02142Least InformativeInherited
Fly Anatomy (FA)cell0.4102Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)anatomical group8.955e-07Moderately InformativeDirect
Fly Anatomy (FA)multi-cell-component structure2.281e-06Moderately InformativeDirect
Fly Anatomy (FA)late embryo0.01967Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.02123Moderately InformativeInherited
Fly Anatomy (FA)cell cluster organ0.06706Moderately InformativeInherited
Fly Anatomy (FA)neuron0.07476Moderately InformativeInherited
Fly Anatomy (FA)sense organ0.1204Moderately InformativeInherited
Fly Anatomy (FA)adult segment0.4391Moderately InformativeInherited
Fly Anatomy (FA)tagmatic subdivision of integument0.5404Moderately InformativeInherited
Fly Anatomy (FA)adult thorax0.7578Moderately InformativeInherited
Fly Anatomy (FA)appendage0.8996Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.9185Moderately InformativeInherited
Fly Anatomy (FA)thoracic segment1Moderately InformativeInherited
Fly Anatomy (FA)chemosensory sensory organ0.01752InformativeInherited
Fly Anatomy (FA)chaeta0.07155InformativeInherited
Fly Anatomy (FA)tract0.2736InformativeInherited
Fly Anatomy (FA)leg0.3187InformativeInherited
Fly Anatomy (FA)commissure2.666e-06Highly InformativeDirect
Fly Anatomy (FA)gustatory receptor neuron0.0003308Highly InformativeDirect
Fly Anatomy (FA)prothoracic leg taste bristle0.000352Highly InformativeDirect
Fly Anatomy (FA)eo neuron0.05788Highly InformativeInherited

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus DEvelopment stage (XDE)embryonic stage7.675e-05Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)shoot apex0Least InformativeDirect
Plant ANatomical entity (PAN)root0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases1.304e-05Least InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosylases1.128e-05Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.1833Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases0.767Moderately InformativeInherited
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0InformativeDirect
Enzyme Commission (EC)Hexosyltransferases1.034e-05InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0Highly InformativeDirect
Enzyme Commission (EC)Chitinase0.0002091Highly InformativeDirect

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)pituitary and hypothalamic hormones and analogues7.078e-06InformativeDirect
Drugbank ATC_code (DB)immunostimulants1.034e-10Highly InformativeDirect
Drugbank ATC_code (DB)somatropin and somatropin agonists2.728e-06Highly InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation0Moderately InformativeDirect
Biological processCarbohydrate metabolism0.1151Moderately InformativeInherited
Biological processAngiogenesis0InformativeDirect
Biological processCell adhesion0InformativeDirect
Biological processEndocytosis0InformativeDirect
Biological processNeurogenesis0InformativeDirect
Biological processPolysaccharide degradation1.167e-05InformativeDirect
Biological processChemotaxis0.0002254InformativeDirect
Biological processAcute phase1.648e-12Highly InformativeDirect
Biological processNotch signaling pathway6.082e-09Highly InformativeDirect
Biological processBlood coagulation1.841e-06Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentCytoskeleton2.509e-08Moderately InformativeDirect
Cellular componentEndosome0.0003257Moderately InformativeDirect
Cellular componentExtracellular matrix0InformativeDirect
Cellular componentGPI-anchor0InformativeDirect
Cellular componentPostsynaptic cell membrane0.0008978InformativeDirect
Coding sequence diversityAlternative splicing0.0001048Least InformativeDirect
DiseaseDisease mutation4.115e-05Least InformativeDirect
DomainRepeat0Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
DomainImmunoglobulin domain0InformativeDirect
DomainEGF-like domain5.947e-15InformativeDirect
DomainLeucine-rich repeat3.16e-11InformativeDirect
DomainCollagen1.386e-08Highly InformativeDirect
Molecular functionHeparin-binding0InformativeDirect
Molecular functionCalmodulin-binding1.51e-06InformativeDirect
Molecular functionActin-binding5.078e-06InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationProtease1Moderately InformativeInherited
Post-translational modificationProtein phosphatase0InformativeDirect
Post-translational modificationMetalloprotease0.0005257InformativeDirect
Post-translational modificationGlycosidase0.0006853InformativeDirect
Post-translational modificationMuscle protein0Highly InformativeDirect
Post-translational modificationTyrosine-protein kinase0Highly InformativeDirect
Post-translational modificationCytokine1.757e-15Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationProteoglycan0.0008367InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism1.342e-05Least InformativeDirect
UniPathway (UP)protein ubiquitination1.789e-10Moderately InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR008957 SSF49265 Protein matches
Abstract

Fibronectin is composed of three repeating structural motifs, of which one is the FnIII module. The three modules form a linear sequence of multiple tandem copies connected by short linker peptides. The secondary structure of the FnIII10 module, which is the only fibronectin module to possess an integrin binding RGD motif, consists of two beta-sheets containing the antiparallel beta-strands ABE and DCFG, respectively, which fold up to form a beta-sandwich. The RGD sequence is located in the loop connecting the beta-strands [PubMed9990027].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 111 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Fibronectin type III domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 111 hidden Markov models representing the Fibronectin type III superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]