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Fibronectin type III superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Immunoglobulin-like beta-sandwich [ 48725] (28)
Superfamily:   Fibronectin type III [ 49265]
Families:   Fibronectin type III [ 49266] (44)


Superfamily statistics
Genomes (1,736) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 71,149 0 172
Proteins 29,622 0 117


Functional annotation
General category Processes_EC
Detailed category Cell adhesion

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0.000000000000007826Least InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl0.00000000004277Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.1816Moderately InformativeInherited
Enzyme Commission (EC)Receptor protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0InformativeDirect
Enzyme Commission (EC)Chitinase0.0002219Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.5337Least InformativeInherited
Disease Ontology (DO)urinary system disease0.235Moderately InformativeInherited
Disease Ontology (DO)neurodegenerative disease0.4836Moderately InformativeInherited
Disease Ontology (DO)disease by infectious agent0.5738Moderately InformativeInherited
Disease Ontology (DO)primary bacterial infectious disease0.7038InformativeInherited
Disease Ontology (DO)acute kidney failure0.000001623Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.007521Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.2371Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.6375Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.6553Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.9233Least InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.004721Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.02555Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.1204Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development0.1595Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.24Moderately InformativeInherited
Mammalian Phenotype (MP)reproductive system phenotype0.5313Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.8025Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal circulating cytokine level0.000002403InformativeDirect
Mammalian Phenotype (MP)autoimmune response0.0001173InformativeDirect
Mammalian Phenotype (MP)abnormal cell differentiation0.002716InformativeInherited
Mammalian Phenotype (MP)abnormal heart layer morphology0.1193InformativeInherited
Mammalian Phenotype (MP)abnormal female reproductive system physiology0.213InformativeInherited
Mammalian Phenotype (MP)abnormal white adipose tissue morphology0.3796InformativeInherited
Mammalian Phenotype (MP)abnormal interferon level0.4774InformativeInherited
Mammalian Phenotype (MP)abnormal spermatogenesis0.6092InformativeInherited
Mammalian Phenotype (MP)increased apoptosis0.8062InformativeInherited
Mammalian Phenotype (MP)abnormal adipose tissue amount0.8314InformativeInherited
Mammalian Phenotype (MP)abnormal axon guidance0.0004411Highly InformativeDirect
Mammalian Phenotype (MP)abnormal spermiogenesis0.08929Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell morphology variant0.00002392Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.0002227Least InformativeDirect
Worm Phenotype (WP)cell development variant0.0007958Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.005531Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.03089Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.1588Least InformativeInherited
Worm Phenotype (WP)nervous system morphology variant0.001442Moderately InformativeInherited
Worm Phenotype (WP)metabolic pathway variant0.001924Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.01078Moderately InformativeInherited
Worm Phenotype (WP)reproductive system development variant0.02774Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.04557Moderately InformativeInherited
Worm Phenotype (WP)cell component morphology variant0.9989Moderately InformativeInherited
Worm Phenotype (WP)locomotion reduced0.000003997InformativeDirect
Worm Phenotype (WP)protein degradation variant0.000004076InformativeDirect
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.00004435InformativeDirect
Worm Phenotype (WP)body posture variant0.0002887InformativeDirect
Worm Phenotype (WP)mitochondria morphology variant0.0003248InformativeDirect
Worm Phenotype (WP)growth rate variant0.0008898InformativeDirect
Worm Phenotype (WP)neuronal outgrowth variant0.001071InformativeInherited
Worm Phenotype (WP)locomotor coordination variant0.002038InformativeInherited
Worm Phenotype (WP)muscle cell physiology variant0.004568InformativeInherited
Worm Phenotype (WP)cell fate specification variant0.02513InformativeInherited
Worm Phenotype (WP)forward locomotion variant0.02618InformativeInherited
Worm Phenotype (WP)anchor cell invasion variant0.00000000003062Highly InformativeDirect
Worm Phenotype (WP)muscle arm development defective0.000000004357Highly InformativeDirect
Worm Phenotype (WP)forward locomotion decreased0.00003694Highly InformativeDirect
Worm Phenotype (WP)loss of left right asymmetry0.09668Highly InformativeInherited
Worm Phenotype (WP)neuronal cell fate specification variant0.1978Highly InformativeInherited
Worm Phenotype (WP)axon development variant0.4166Highly InformativeInherited
Worm Phenotype (WP)path curvature variant0.7276Highly InformativeInherited
Worm Phenotype (WP)axon morphology variant0.7701Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system subdivision0.0003034Least InformativeDirect
Fly Anatomy (FA)anatomical group0.001735Least InformativeInherited
Fly Anatomy (FA)embryo0.02319Least InformativeInherited
Fly Anatomy (FA)nervous system0.02995Least InformativeInherited
Fly Anatomy (FA)larva0.03603Least InformativeInherited
Fly Anatomy (FA)adult0.1189Least InformativeInherited
Fly Anatomy (FA)somatic cell0.3244Least InformativeInherited
Fly Anatomy (FA)integumentary system0.433Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.00000002301Moderately InformativeDirect
Fly Anatomy (FA)central nervous system0.01497Moderately InformativeInherited
Fly Anatomy (FA)sensory neuron0.02524Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.0297Moderately InformativeInherited
Fly Anatomy (FA)late embryo0.06559Moderately InformativeInherited
Fly Anatomy (FA)cell cluster organ0.1105Moderately InformativeInherited
Fly Anatomy (FA)sense organ0.1922Moderately InformativeInherited
Fly Anatomy (FA)adult segment0.2043Moderately InformativeInherited
Fly Anatomy (FA)adult thorax0.7309Moderately InformativeInherited
Fly Anatomy (FA)appendage0.9448Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.9698Moderately InformativeInherited
Fly Anatomy (FA)thoracic segment1Moderately InformativeInherited
Fly Anatomy (FA)tagmatic subdivision of integument1Moderately InformativeInherited
Fly Anatomy (FA)larval abdomen0.0000005244InformativeDirect
Fly Anatomy (FA)synaptic neuropil0.0001482InformativeDirect
Fly Anatomy (FA)nerve0.000587InformativeDirect
Fly Anatomy (FA)chemosensory system0.02859InformativeInherited
Fly Anatomy (FA)chaeta0.09318InformativeInherited
Fly Anatomy (FA)leg0.3007InformativeInherited
Fly Anatomy (FA)midline crossing tract0.4221InformativeInherited
Fly Anatomy (FA)prothoracic leg taste bristle chemosensory neuron0.00001198Highly InformativeDirect
Fly Anatomy (FA)commissure0.00002302Highly InformativeDirect
Fly Anatomy (FA)multidendritic neuron0.04671Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)compound organ0.03144Least InformativeInherited
Zebrafish Anatomy (ZA)multi-tissue structure0.1235Least InformativeInherited
Zebrafish Anatomy (ZA)nervous system0.6291Least InformativeInherited
Zebrafish Anatomy (ZA)central nervous system0.2719Moderately InformativeInherited
Zebrafish Anatomy (ZA)brain0.3619InformativeInherited
Zebrafish Anatomy (ZA)medial longitudinal fasciculus0.0003422Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system0.659Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.9288Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.9834Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue1Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.08969Moderately InformativeInherited
Xenopus ANatomical entity (XAN)sensory system0.3169Moderately InformativeInherited
Xenopus ANatomical entity (XAN)eye0.5533InformativeInherited
Xenopus ANatomical entity (XAN)retinal ganglion cell layer0.0005659Highly InformativeDirect
Xenopus DEvelopment stage (XDE)embryonic stage0.00001691Moderately InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases0.000008624Least InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosylases0.00002223Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.1218Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases0.7845Moderately InformativeInherited
Enzyme Commission (EC)Acyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0InformativeDirect
Enzyme Commission (EC)RING-type E3 ubiquitin transferase0.0000000008496InformativeDirect
Enzyme Commission (EC)Hexosyltransferases0.00001496InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0Highly InformativeDirect
Enzyme Commission (EC)Chitinase0.0005566Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation0Moderately InformativeDirect
Biological processCarbohydrate metabolism0.1756Moderately InformativeInherited
Biological processAngiogenesis0InformativeDirect
Biological processCell adhesion0InformativeDirect
Biological processEndocytosis0InformativeDirect
Biological processNeurogenesis0InformativeDirect
Biological processHemostasis0.000002964InformativeDirect
Biological processPolysaccharide degradation0.00005749InformativeDirect
Biological processChemotaxis0.0005285InformativeDirect
Biological processSensory transduction0.03927InformativeInherited
Biological processAcute phase0.000000000001926Highly InformativeDirect
Biological processNotch signaling pathway0.00000001496Highly InformativeDirect
Biological processBlood coagulation0.000002815Highly InformativeDirect
Biological processVision0.00003098Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentCytoskeleton0.0000000001156Moderately InformativeDirect
Cellular componentEndosome0.00000001469Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.0009613Moderately InformativeDirect
Cellular componentExtracellular matrix0InformativeDirect
Cellular componentGPI-anchor0InformativeDirect
Coding sequence diversityAlternative splicing0.000002856Least InformativeDirect
DiseaseDisease mutation0.000002551Least InformativeDirect
DomainRepeat0Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
DomainImmunoglobulin domain0InformativeDirect
DomainEGF-like domain0.000000000000002458InformativeDirect
DomainLeucine-rich repeat0.00000000000004023InformativeDirect
DomainSH3 domain0.0002033InformativeDirect
DomainCollagen0.000000006676Highly InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationHeparin-binding0InformativeDirect
Post-translational modificationProtein phosphatase0InformativeDirect
Post-translational modificationCalmodulin-binding0.000003245InformativeDirect
Post-translational modificationActin-binding0.000021InformativeDirect
Post-translational modificationGlycosidase0.0002536InformativeDirect
Post-translational modificationMuscle protein0Highly InformativeDirect
Post-translational modificationTyrosine-protein kinase0Highly InformativeDirect
Post-translational modificationCytokine0.000000000000002876Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationProteoglycan0.000002319InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR008957 SSF49265 Protein matches
Abstract

Fibronectin is composed of three repeating structural motifs, of which one is the FnIII module. The three modules form a linear sequence of multiple tandem copies connected by short linker peptides. The secondary structure of the FnIII10 module, which is the only fibronectin module to possess an integrin binding RGD motif, consists of two beta-sheets containing the antiparallel beta-strands ABE and DCFG, respectively, which fold up to form a beta-sandwich. The RGD sequence is located in the loop connecting the beta-strands [PubMed9990027].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 111 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Fibronectin type III domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 111 hidden Markov models representing the Fibronectin type III superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]