SUPERFAMILY 1.75 HMM library and genome assignments server


Fibronectin type III superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Immunoglobulin-like beta-sandwich [ 48725] (28)
Superfamily:   Fibronectin type III [ 49265]
Families:   Fibronectin type III [ 49266] (44)


Superfamily statistics
Genomes (1,678) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 64,139 69,426 172
Proteins 26,711 33,746 117


Functional annotation
General category Processes_EC
Detailed category Cell adhesion

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process2.52e-066.285e-06Least InformativeDirect
Biological Process (BP)multicellular organismal process0.00031920Least InformativeDirect
Biological Process (BP)single-organism cellular process0.00050990Least InformativeDirect
Biological Process (BP)response to stimulus0.00082950Least InformativeDirect
Biological Process (BP)developmental process0.0050270Least InformativeInherited
Biological Process (BP)localization0.042362.588e-10Least InformativeInherited
Biological Process (BP)reproduction1.882e-050.0007659Moderately InformativeDirect
Biological Process (BP)cell differentiation7.198e-056.628e-10Moderately InformativeDirect
Biological Process (BP)tissue development3.757e-061Moderately InformativeInherited
Biological Process (BP)organ development0.00010860.03874Moderately InformativeInherited
Biological Process (BP)single-organism developmental process0.11380Moderately InformativeInherited
Biological Process (BP)response to endogenous stimulus0.036891Moderately InformativeInherited
Biological Process (BP)response to organic substance6.368e-071Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.00033260.5049Moderately InformativeInherited
Biological Process (BP)signal transduction0.0042350Moderately InformativeInherited
Biological Process (BP)response to cytokine stimulus1.281e-120InformativeDirect
Biological Process (BP)growth0.00010920InformativeDirect
Biological Process (BP)regulation of body fluid levels0.00011461.22e-13InformativeDirect
Biological Process (BP)gland development1.408e-060.6227InformativeInherited
Biological Process (BP)epithelium development1.433e-070.4011InformativeInherited
Biological Process (BP)cellular response to endogenous stimulus0.00013850.01168InformativeInherited
Biological Process (BP)response to hormone stimulus0.30721InformativeInherited
Biological Process (BP)reproductive structure development1.903e-081InformativeInherited
Biological Process (BP)multicellular organismal reproductive process0.042530.001137InformativeInherited
Biological Process (BP)intracellular signal transduction0.30231InformativeInherited
Biological Process (BP)cytokine-mediated signaling pathway00Highly InformativeDirect
Biological Process (BP)mammary gland alveolus development3.424e-080.0005105Highly InformativeDirect
Biological Process (BP)regulation of cell adhesion6.921e-060Highly InformativeDirect
Biological Process (BP)lactation3.083e-058.829e-05Highly InformativeDirect
Biological Process (BP)mammary gland epithelium development0.00023410.0003918Highly InformativeDirect
Biological Process (BP)developmental growth0.00031978.652e-10Highly InformativeDirect
Biological Process (BP)hormone-mediated signaling pathway0.0011471Highly InformativeInherited
Molecular Function (MF)binding0.010420Least InformativeInherited
Molecular Function (MF)receptor activity1.714e-080InformativeDirect
Molecular Function (MF)molecular transducer activity3.355e-080InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 6.285e-06 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) localization 2.588e-10 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) protein metabolic process 0 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 2.447e-14 Least Informative Direct
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) reproduction 0.0007659 Moderately Informative Direct
Biological Process (BP) cell differentiation 6.628e-10 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0 Moderately Informative Direct
Biological Process (BP) signal transduction 0 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 0 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0 Moderately Informative Direct
Biological Process (BP) nervous system development 0 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) immune system process 3.746e-15 Moderately Informative Direct
Biological Process (BP) multi-organism process 2.082e-12 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 7.088e-10 Moderately Informative Direct
Biological Process (BP) system process 2.4e-06 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.000105 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) homeostatic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.6439 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.3491 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.9203 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.5049 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) regulation of programmed cell death 0.1363 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.6568 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) organ development 0.03874 Moderately Informative Inherited
Biological Process (BP) response to cytokine stimulus 0 Informative Direct
Biological Process (BP) growth 0 Informative Direct
Biological Process (BP) regulation of body fluid levels 1.22e-13 Informative Direct
Biological Process (BP) cellular component movement 0 Informative Direct
Biological Process (BP) central nervous system development 0 Informative Direct
Biological Process (BP) biological adhesion 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) cell projection organization 0 Informative Direct
Biological Process (BP) localization of cell 0 Informative Direct
Biological Process (BP) response to wounding 0 Informative Direct
Biological Process (BP) generation of neurons 0 Informative Direct
Biological Process (BP) cellular component morphogenesis 0 Informative Direct
Biological Process (BP) regulation of nervous system development 1.431e-14 Informative Direct
Biological Process (BP) regulation of cell development 3.023e-13 Informative Direct
Biological Process (BP) vesicle-mediated transport 3.974e-13 Informative Direct
Biological Process (BP) phosphorylation 4.735e-13 Informative Direct
Biological Process (BP) dephosphorylation 1.778e-12 Informative Direct
Biological Process (BP) blood circulation 3.313e-10 Informative Direct
Biological Process (BP) positive regulation of developmental process 2.615e-09 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 5.752e-09 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 4.919e-08 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 1.088e-07 Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 7.354e-07 Informative Direct
Biological Process (BP) regulation of locomotion 2.336e-06 Informative Direct
Biological Process (BP) defense response 2.446e-06 Informative Direct
Biological Process (BP) regulation of nucleotide catabolic process 3.384e-06 Informative Direct
Biological Process (BP) organelle assembly 3.875e-06 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 4.558e-06 Informative Direct
Biological Process (BP) regulation of cellular component movement 5.274e-06 Informative Direct
Biological Process (BP) response to bacterium 5.482e-06 Informative Direct
Biological Process (BP) cytoskeleton organization 9.213e-06 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 1.001e-05 Informative Direct
Biological Process (BP) positive regulation of cell proliferation 1.524e-05 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 4.183e-05 Informative Direct
Biological Process (BP) cell activation 6.459e-05 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0.0001383 Informative Direct
Biological Process (BP) regulation of peptidase activity 0.0009019 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0.08713 Informative Inherited
Biological Process (BP) epithelium development 0.4011 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.01168 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 1 Informative Inherited
Biological Process (BP) response to organonitrogen compound 1 Informative Inherited
Biological Process (BP) response to hormone stimulus 1 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.939 Informative Inherited
Biological Process (BP) tissue morphogenesis 1 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 1 Informative Inherited
Biological Process (BP) gland development 0.6227 Informative Inherited
Biological Process (BP) cell-cell signaling 1 Informative Inherited
Biological Process (BP) metal ion transport 1 Informative Inherited
Biological Process (BP) cation homeostasis 0.9408 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 1 Informative Inherited
Biological Process (BP) cytoplasmic transport 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.7004 Informative Inherited
Biological Process (BP) transmission of nerve impulse 1 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.00315 Informative Inherited
Biological Process (BP) regulation of defense response 0.665 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.01169 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.0823 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.5134 Informative Inherited
Biological Process (BP) regulation of cell cycle 1 Informative Inherited
Biological Process (BP) regulation of growth 0.2023 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.6419 Informative Inherited
Biological Process (BP) membrane organization 1 Informative Inherited
Biological Process (BP) regulation of kinase activity 1 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.7559 Informative Inherited
Biological Process (BP) negative regulation of cell death 0.001291 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.01317 Informative Inherited
Biological Process (BP) immune response 0.8385 Informative Inherited
Biological Process (BP) immune effector process 0.1125 Informative Inherited
Biological Process (BP) secondary metabolic process 0.6455 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.001716 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.005007 Informative Inherited
Biological Process (BP) regulation of cytokine production 1 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) protein complex assembly 0.376 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 1 Informative Inherited
Biological Process (BP) reproductive structure development 1 Informative Inherited
Biological Process (BP) actin filament-based process 0.03027 Informative Inherited
Biological Process (BP) muscle structure development 0.01384 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.9241 Informative Inherited
Biological Process (BP) muscle tissue development 0.04128 Informative Inherited
Biological Process (BP) sensory organ development 1 Informative Inherited
Biological Process (BP) embryonic morphogenesis 1 Informative Inherited
Biological Process (BP) organ morphogenesis 0.6401 Informative Inherited
Biological Process (BP) single-organism behavior 0.6834 Informative Inherited
Biological Process (BP) sexual reproduction 0.1119 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.001137 Informative Inherited
Biological Process (BP) single organism reproductive process 0.7157 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.3663 Informative Inherited
Biological Process (BP) cell death 1 Informative Inherited
Biological Process (BP) glycerolipid metabolic process 0.7358 Informative Inherited
Biological Process (BP) pigment metabolic process 0.04504 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.2149 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.7918 Informative Inherited
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) regulation of immune effector process 0.0162 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 1 Informative Inherited
Biological Process (BP) cytokine-mediated signaling pathway 0 Highly Informative Direct
Biological Process (BP) mammary gland alveolus development 0.0005105 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 0 Highly Informative Direct
Biological Process (BP) lactation 8.829e-05 Highly Informative Direct
Biological Process (BP) mammary gland epithelium development 0.0003918 Highly Informative Direct
Biological Process (BP) developmental growth 8.652e-10 Highly Informative Direct
Biological Process (BP) protein phosphorylation 0 Highly Informative Direct
Biological Process (BP) phagocytosis 0 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 0 Highly Informative Direct
Biological Process (BP) chemotaxis 0 Highly Informative Direct
Biological Process (BP) neuron projection development 0 Highly Informative Direct
Biological Process (BP) peptidyl-tyrosine modification 0 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0 Highly Informative Direct
Biological Process (BP) cell adhesion 0 Highly Informative Direct
Biological Process (BP) regulation of neuron projection development 0 Highly Informative Direct
Biological Process (BP) protein dephosphorylation 0 Highly Informative Direct
Biological Process (BP) cell growth 0 Highly Informative Direct
Biological Process (BP) negative regulation of immune system process 1.931e-15 Highly Informative Direct
Biological Process (BP) cell junction organization 9.23e-14 Highly Informative Direct
Biological Process (BP) positive regulation of peptidase activity 7.006e-12 Highly Informative Direct
Biological Process (BP) negative regulation of response to external stimulus 2.467e-11 Highly Informative Direct
Biological Process (BP) actomyosin structure organization 8.867e-11 Highly Informative Direct
Biological Process (BP) spermatogenesis 2.282e-09 Highly Informative Direct
Biological Process (BP) regulation of lymphocyte mediated immunity 2.423e-09 Highly Informative Direct
Biological Process (BP) cell part morphogenesis 3.42e-09 Highly Informative Direct
Biological Process (BP) negative regulation of neuron death 1.143e-08 Highly Informative Direct
Biological Process (BP) positive regulation of protein kinase B signaling cascade 1.351e-08 Highly Informative Direct
Biological Process (BP) regulation of mononuclear cell proliferation 2.028e-08 Highly Informative Direct
Biological Process (BP) regulation of neuron apoptotic process 2.191e-08 Highly Informative Direct
Biological Process (BP) negative regulation of locomotion 5.687e-08 Highly Informative Direct
Biological Process (BP) regulation of Rho protein signal transduction 8.224e-08 Highly Informative Direct
Biological Process (BP) eye morphogenesis 6.672e-07 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 1.064e-06 Highly Informative Direct
Biological Process (BP) negative regulation of cellular component movement 1.372e-06 Highly Informative Direct
Biological Process (BP) coagulation 1.426e-05 Highly Informative Direct
Biological Process (BP) cellular response to peptide 2.498e-05 Highly Informative Direct
Biological Process (BP) regulation of Ras GTPase activity 2.59e-05 Highly Informative Direct
Biological Process (BP) regulation of inflammatory response 2.961e-05 Highly Informative Direct
Biological Process (BP) regulation of cell size 3.121e-05 Highly Informative Direct
Biological Process (BP) collagen metabolic process 3.279e-05 Highly Informative Direct
Biological Process (BP) sensory perception 3.471e-05 Highly Informative Direct
Biological Process (BP) positive regulation of cell differentiation 5.335e-05 Highly Informative Direct
Biological Process (BP) response to ethanol 7.988e-05 Highly Informative Direct
Biological Process (BP) protein tetramerization 8.637e-05 Highly Informative Direct
Biological Process (BP) regulation of cell killing 0.0001105 Highly Informative Direct
Biological Process (BP) regulation of cell growth 0.000132 Highly Informative Direct
Biological Process (BP) positive regulation of cell activation 0.0001419 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 0.0008085 Highly Informative Direct
Biological Process (BP) regulation of cysteine-type endopeptidase activity 0.02119 Highly Informative Inherited
Biological Process (BP) renal system development 0.5592 Highly Informative Inherited
Biological Process (BP) response to peptide hormone stimulus 0.002142 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.9207 Highly Informative Inherited
Biological Process (BP) wound healing 0.01174 Highly Informative Inherited
Biological Process (BP) hemostasis 1 Highly Informative Inherited
Biological Process (BP) actin filament-based movement 1 Highly Informative Inherited
Biological Process (BP) calcium ion transport 0.4817 Highly Informative Inherited
Biological Process (BP) cellular calcium ion homeostasis 0.1678 Highly Informative Inherited
Biological Process (BP) regulation of actin cytoskeleton organization 0.001336 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.06429 Highly Informative Inherited
Biological Process (BP) regulation of ion homeostasis 0.2158 Highly Informative Inherited
Biological Process (BP) immune response-regulating signaling pathway 1 Highly Informative Inherited
Biological Process (BP) activation of immune response 1 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 1 Highly Informative Inherited
Biological Process (BP) regulation of production of molecular mediator of immune response 0.7867 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 0.5107 Highly Informative Inherited
Biological Process (BP) cell fate commitment 1 Highly Informative Inherited
Biological Process (BP) regulation of mitosis 0.1055 Highly Informative Inherited
Biological Process (BP) positive regulation of cell cycle process 0.368 Highly Informative Inherited
Biological Process (BP) regulation of innate immune response 0.1688 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.005162 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.5123 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 0.9919 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 0.914 Highly Informative Inherited
Biological Process (BP) developmental maturation 1 Highly Informative Inherited
Biological Process (BP) positive regulation of lipid metabolic process 0.04364 Highly Informative Inherited
Biological Process (BP) B cell activation 0.6644 Highly Informative Inherited
Biological Process (BP) hormone-mediated signaling pathway 1 Highly Informative Inherited
Biological Process (BP) pattern specification process 1 Highly Informative Inherited
Biological Process (BP) innate immune response 1 Highly Informative Inherited
Biological Process (BP) cell proliferation 0.1034 Highly Informative Inherited
Biological Process (BP) positive regulation of GTPase activity 1 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.03127 Highly Informative Inherited
Biological Process (BP) development of primary female sexual characteristics 0.9234 Highly Informative Inherited
Biological Process (BP) cellular component assembly involved in morphogenesis 0.009379 Highly Informative Inherited
Biological Process (BP) glycosaminoglycan metabolic process 1 Highly Informative Inherited
Biological Process (BP) cell projection assembly 0.7549 Highly Informative Inherited
Biological Process (BP) telencephalon development 0.001843 Highly Informative Inherited
Biological Process (BP) peptidyl-serine modification 1 Highly Informative Inherited
Biological Process (BP) regulation of angiogenesis 0.03008 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.9654 Highly Informative Inherited
Biological Process (BP) retina development in camera-type eye 0.29 Highly Informative Inherited
Biological Process (BP) acylglycerol metabolic process 0.001862 Highly Informative Inherited
Biological Process (BP) protein glycosylation 1 Highly Informative Inherited
Biological Process (BP) negative regulation of phosphorylation 0.1836 Highly Informative Inherited
Biological Process (BP) negative regulation of protein modification process 0.2668 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.1112 Highly Informative Inherited
Biological Process (BP) regulation of blood pressure 0.001399 Highly Informative Inherited
Biological Process (BP) positive regulation of adaptive immune response 0.007473 Highly Informative Inherited
Biological Process (BP) leukocyte migration 0.005702 Highly Informative Inherited
Biological Process (BP) inflammatory response 0.02227 Highly Informative Inherited
Biological Process (BP) protein processing 0.06343 Highly Informative Inherited
Biological Process (BP) regulation of adaptive immune response based on somatic recombination of immune receptors built from 0.4077 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 1 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) structural molecule activity 0 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 1.555e-15 Moderately Informative Direct
Molecular Function (MF) anion binding 2.994e-08 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 0.6536 Moderately Informative Inherited
Molecular Function (MF) receptor activity 0 Informative Direct
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) protein dimerization activity 0 Informative Direct
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0 Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0 Informative Direct
Molecular Function (MF) phosphatase activity 0 Informative Direct
Molecular Function (MF) sulfur compound binding 0 Informative Direct
Molecular Function (MF) peptidase regulator activity 8.749e-06 Informative Direct
Molecular Function (MF) amide binding 0.03103 Informative Inherited
Molecular Function (MF) carboxylic acid binding 0.9365 Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0.9849 Informative Inherited
Molecular Function (MF) enzyme binding 1 Informative Inherited
Molecular Function (MF) enzyme activator activity 0.008238 Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 1 Informative Inherited
Molecular Function (MF) receptor binding 0.8983 Informative Inherited
Molecular Function (MF) antigen binding 0 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0 Highly Informative Direct
Molecular Function (MF) heparin binding 0 Highly Informative Direct
Molecular Function (MF) phosphoprotein phosphatase activity 0 Highly Informative Direct
Molecular Function (MF) hormone binding 5.601e-07 Highly Informative Direct
Molecular Function (MF) peptide binding 2.234e-05 Highly Informative Direct
Molecular Function (MF) protein homodimerization activity 0.0006355 Highly Informative Direct
Molecular Function (MF) UDP-glycosyltransferase activity 0.002135 Highly Informative Inherited
Molecular Function (MF) transferase activity, transferring hexosyl groups 0.04309 Highly Informative Inherited
Molecular Function (MF) protein complex binding 0.238 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.06756 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane part 0 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 1.06e-10 Moderately Informative Direct
Cellular Component (CC) organelle membrane 1 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.02961 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 0.9454 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 1 Moderately Informative Inherited
Cellular Component (CC) neuron projection 0 Informative Direct
Cellular Component (CC) extracellular matrix 0 Informative Direct
Cellular Component (CC) contractile fiber part 0 Informative Direct
Cellular Component (CC) cell surface 0 Informative Direct
Cellular Component (CC) intrinsic to plasma membrane 2.972e-15 Informative Direct
Cellular Component (CC) cell leading edge 6.186e-09 Informative Direct
Cellular Component (CC) endosome 1.031e-05 Informative Direct
Cellular Component (CC) nuclear envelope 0.0003023 Informative Direct
Cellular Component (CC) integral to membrane 0.0003537 Informative Direct
Cellular Component (CC) cell-cell junction 1 Informative Inherited
Cellular Component (CC) actin cytoskeleton 1 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) proteinaceous extracellular matrix 0 Highly Informative Direct
Cellular Component (CC) cell body 0 Highly Informative Direct
Cellular Component (CC) adherens junction 0 Highly Informative Direct
Cellular Component (CC) extracellular matrix part 0 Highly Informative Direct
Cellular Component (CC) integral to plasma membrane 8.634e-15 Highly Informative Direct
Cellular Component (CC) receptor complex 4.074e-10 Highly Informative Direct
Cellular Component (CC) dendrite 3.54e-06 Highly Informative Direct
Cellular Component (CC) endosomal part 9.617e-05 Highly Informative Direct
Cellular Component (CC) microtubule associated complex 0.0001795 Highly Informative Direct
Cellular Component (CC) lateral plasma membrane 0.0002738 Highly Informative Direct
Cellular Component (CC) myosin complex 0.000709 Highly Informative Direct
Cellular Component (CC) early endosome 0.03664 Highly Informative Inherited
Cellular Component (CC) sarcomere 0.01729 Highly Informative Inherited
Cellular Component (CC) cell-substrate junction 0.006207 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds7.826e-15Least InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl4.277e-11Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.1816Moderately InformativeInherited
Enzyme Commission (EC)Receptor protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0InformativeDirect
Enzyme Commission (EC)Chitinase0.0002219Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)kidney disease0.09233Moderately InformativeInherited
Disease Ontology (DO)bacterial infectious disease0.5712Moderately InformativeInherited
Disease Ontology (DO)cardiomyopathy0.0005424InformativeDirect
Disease Ontology (DO)kidney failure0.0236InformativeInherited
Disease Ontology (DO)primary bacterial infectious disease0.6878InformativeInherited
Disease Ontology (DO)acute kidney failure2.114e-06Highly InformativeDirect
Disease Ontology (DO)leprosy0.03146Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the skeletal system0.415Least InformativeInherited
Phenotypic Abnormality (PA)Salmonella osteomyelitis8.503e-05Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.03837Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.3314Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.6706Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.758Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.8879Least InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.005195Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.009818Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development0.2236Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.2497Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.2834Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.8498Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryogenesis/ development1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal circulating cytokine level1.095e-05InformativeDirect
Mammalian Phenotype (MP)abnormal cell differentiation0.01236InformativeInherited
Mammalian Phenotype (MP)abnormal internal female genitalia morphology0.0557InformativeInherited
Mammalian Phenotype (MP)abnormal heart layer morphology0.1177InformativeInherited
Mammalian Phenotype (MP)abnormal interferon level0.3355InformativeInherited
Mammalian Phenotype (MP)abnormal placenta morphology0.6198InformativeInherited
Mammalian Phenotype (MP)abnormal spermatogenesis0.628InformativeInherited
Mammalian Phenotype (MP)abnormal axon guidance0.0005388Highly InformativeDirect
Mammalian Phenotype (MP)abnormal uterus morphology0.008359Highly InformativeInherited
Mammalian Phenotype (MP)abnormal spermiogenesis0.0497Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.02119Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.0997Least InformativeInherited
Worm Phenotype (WP)growth variant0.7352Least InformativeInherited
Worm Phenotype (WP)organ system development variant3.815e-07Moderately InformativeDirect
Worm Phenotype (WP)cell homeostasis metabolism variant0.007356Moderately InformativeInherited
Worm Phenotype (WP)locomotion variant0.00995Moderately InformativeInherited
Worm Phenotype (WP)anchor cell invasion variant1.004e-10InformativeDirect
Worm Phenotype (WP)neuron development variant5.758e-07InformativeDirect
Worm Phenotype (WP)cell migration variant0.0005568InformativeDirect
Worm Phenotype (WP)muscle cell morphology variant0.001963InformativeInherited
Worm Phenotype (WP)activity level variant0.01276InformativeInherited
Worm Phenotype (WP)locomotor coordination variant0.01636InformativeInherited
Worm Phenotype (WP)protein metabolism variant0.04595InformativeInherited
Worm Phenotype (WP)organism stress response variant0.647InformativeInherited
Worm Phenotype (WP)muscle arm development defective7.638e-09Highly InformativeDirect
Worm Phenotype (WP)axon morphology variant2.387e-08Highly InformativeDirect
Worm Phenotype (WP)myopodia present5.88e-06Highly InformativeDirect
Worm Phenotype (WP)protein degradation variant0.0001454Highly InformativeDirect
Worm Phenotype (WP)roller0.0001569Highly InformativeDirect
Worm Phenotype (WP)growth rate variant0.0008138Highly InformativeDirect
Worm Phenotype (WP)loss of asymmetry ASE0.0009604Highly InformativeDirect
Worm Phenotype (WP)axon development variant0.5179Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)cell adhesion defective3.561e-05Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system subdivision9.521e-05Least InformativeDirect
Fly Anatomy (FA)anatomical group0.0006052Least InformativeDirect
Fly Anatomy (FA)organ system0.004265Least InformativeInherited
Fly Anatomy (FA)larva0.03659Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.1099Least InformativeInherited
Fly Anatomy (FA)cell0.4849Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)multi-cell-component structure2.825e-06Moderately InformativeDirect
Fly Anatomy (FA)late embryo0.03684Moderately InformativeInherited
Fly Anatomy (FA)cell cluster organ0.03705Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.0538Moderately InformativeInherited
Fly Anatomy (FA)sense organ0.0718Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.09881Moderately InformativeInherited
Fly Anatomy (FA)neuron0.1309Moderately InformativeInherited
Fly Anatomy (FA)adult nervous system0.1784Moderately InformativeInherited
Fly Anatomy (FA)adult segment0.4486Moderately InformativeInherited
Fly Anatomy (FA)tagmatic subdivision of integument0.5445Moderately InformativeInherited
Fly Anatomy (FA)adult thorax0.6396Moderately InformativeInherited
Fly Anatomy (FA)appendage0.8406Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.9006Moderately InformativeInherited
Fly Anatomy (FA)head0.907Moderately InformativeInherited
Fly Anatomy (FA)thoracic segment0.9876Moderately InformativeInherited
Fly Anatomy (FA)ganglion0.01417InformativeInherited
Fly Anatomy (FA)chemosensory system0.02267InformativeInherited
Fly Anatomy (FA)chaeta0.047InformativeInherited
Fly Anatomy (FA)synaptic neuropil block0.0767InformativeInherited
Fly Anatomy (FA)brain0.1318InformativeInherited
Fly Anatomy (FA)adult procephalic segment0.1367InformativeInherited
Fly Anatomy (FA)adult central nervous system0.1471InformativeInherited
Fly Anatomy (FA)tract0.3071InformativeInherited
Fly Anatomy (FA)leg0.3122InformativeInherited
Fly Anatomy (FA)synaptic neuropil domain0.4265InformativeInherited
Fly Anatomy (FA)protocerebrum0.8796InformativeInherited
Fly Anatomy (FA)gustatory receptor neuron0.0002319Highly InformativeDirect
Fly Anatomy (FA)prothoracic leg taste bristle0.0003581Highly InformativeDirect
Fly Anatomy (FA)lobe system of adult mushroom body0.0007218Highly InformativeDirect
Fly Anatomy (FA)eo neuron0.05547Highly InformativeInherited

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus DEvelopment stage (XDE)NF stage6.295e-05Least InformativeDirect
Xenopus DEvelopment stage (XDE)embryonic stage7.809e-05Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases5.96e-07Least InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosylases1.476e-05Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.1726Moderately InformativeInherited
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0Highly InformativeDirect
Enzyme Commission (EC)Chitinase0.0002027Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation0Moderately InformativeDirect
Biological processCarbohydrate metabolism0.1601Moderately InformativeInherited
Biological processAngiogenesis0InformativeDirect
Biological processCell adhesion0InformativeDirect
Biological processEndocytosis0InformativeDirect
Biological processNeurogenesis0InformativeDirect
Biological processHemostasis2.387e-06InformativeDirect
Biological processPolysaccharide degradation6.277e-05InformativeDirect
Biological processChemotaxis0.000287InformativeDirect
Biological processAcute phase1.69e-12Highly InformativeDirect
Biological processNotch signaling pathway1.293e-08Highly InformativeDirect
Biological processBlood coagulation2.263e-06Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentCytoskeleton9.094e-08Moderately InformativeDirect
Cellular componentEndosome4.562e-05Moderately InformativeDirect
Cellular componentExtracellular matrix0InformativeDirect
Cellular componentGPI-anchor0InformativeDirect
Coding sequence diversityAlternative splicing1.505e-05Least InformativeDirect
DiseaseDisease mutation1.621e-05Least InformativeDirect
DomainRepeat0Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
DomainImmunoglobulin domain0InformativeDirect
DomainEGF-like domain1.228e-15InformativeDirect
DomainLeucine-rich repeat8.836e-12InformativeDirect
DomainCollagen6.417e-09Highly InformativeDirect
Molecular functionHeparin-binding0InformativeDirect
Molecular functionCalmodulin-binding1.91e-06InformativeDirect
Molecular functionActin-binding1.254e-05InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationProtease1Moderately InformativeInherited
Post-translational modificationProtein phosphatase0InformativeDirect
Post-translational modificationMetalloprotease0.0006176InformativeDirect
Post-translational modificationGlycosidase0.0007798InformativeDirect
Post-translational modificationMuscle protein0Highly InformativeDirect
Post-translational modificationTyrosine-protein kinase0Highly InformativeDirect
Post-translational modificationCytokine1.98e-15Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationProteoglycan0.0009544InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR008957 SSF49265 Protein matches
Abstract

Fibronectin is composed of three repeating structural motifs, of which one is the FnIII module. The three modules form a linear sequence of multiple tandem copies connected by short linker peptides. The secondary structure of the FnIII10 module, which is the only fibronectin module to possess an integrin binding RGD motif, consists of two beta-sheets containing the antiparallel beta-strands ABE and DCFG, respectively, which fold up to form a beta-sandwich. The RGD sequence is located in the loop connecting the beta-strands [PubMed9990027].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 111 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Fibronectin type III domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 111 hidden Markov models representing the Fibronectin type III superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]