SUPERFAMILY 1.75 HMM library and genome assignments server

Fibronectin type III superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Immunoglobulin-like beta-sandwich [ 48725] (28)
Superfamily:   Fibronectin type III [ 49265]
Families:   Fibronectin type III [ 49266] (44)


Superfamily statistics
Genomes (1,728) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 70,300 91,738 172
Proteins 29,229 47,558 117


Functional annotation
General category Processes_EC
Detailed category Cell adhesion

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process0.00000077920.00001489Least InformativeDirect
Biological Process (BP)multicellular organismal process0.000064540Least InformativeDirect
Biological Process (BP)response to stimulus0.00029310Least InformativeDirect
Biological Process (BP)developmental process0.0013780Least InformativeInherited
Biological Process (BP)localization0.061580.000000001985Least InformativeInherited
Biological Process (BP)single-organism cellular process0.0080040Least InformativeInherited
Biological Process (BP)cell differentiation0.000010650.0000000008359Moderately InformativeDirect
Biological Process (BP)reproductive process0.000011870.000004222Moderately InformativeDirect
Biological Process (BP)regulation of multicellular organismal process0.0005380Moderately InformativeDirect
Biological Process (BP)organ development0.045960.01301Moderately InformativeInherited
Biological Process (BP)tissue development0.0012020.01023Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.45880.5063Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.007830Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.00011820.3674Moderately InformativeInherited
Biological Process (BP)signal transduction0.0012440Moderately InformativeInherited
Biological Process (BP)response to endogenous stimulus0.058471Moderately InformativeInherited
Biological Process (BP)response to organic substance0.000000069311Moderately InformativeInherited
Biological Process (BP)response to cytokine0.000000000000024410InformativeDirect
Biological Process (BP)regulation of body fluid levels0.00021870.0000000000003407InformativeDirect
Biological Process (BP)growth0.00050740InformativeDirect
Biological Process (BP)gland development0.000011180.9551InformativeInherited
Biological Process (BP)epithelium development0.00000019681InformativeInherited
Biological Process (BP)cellular response to hormone stimulus0.1950.6693InformativeInherited
Biological Process (BP)reproductive structure development0.000015471InformativeInherited
Biological Process (BP)single organism reproductive process0.00014680.1456InformativeInherited
Biological Process (BP)intracellular signal transduction0.43791InformativeInherited
Biological Process (BP)cytokine-mediated signaling pathway00Highly InformativeDirect
Biological Process (BP)mammary gland alveolus development0.000000070010.0004004Highly InformativeDirect
Biological Process (BP)regulation of cell adhesion0.000012310Highly InformativeDirect
Biological Process (BP)developmental growth0.00034870.0000000000392Highly InformativeDirect
Biological Process (BP)mammary gland epithelium development0.0002150.001047Highly InformativeInherited
Biological Process (BP)hormone-mediated signaling pathway0.0023871Highly InformativeInherited
Molecular Function (MF)binding0.0058030Least InformativeInherited
Molecular Function (MF)receptor activity0.00000000091890InformativeDirect
Molecular Function (MF)molecular transducer activity0.0000000019120InformativeDirect
Molecular Function (MF)transmembrane signaling receptor activity0.000000000054990Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 0.00001489 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) localization 0.000000001985 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) protein metabolic process 0 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0 Least Informative Direct
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) positive regulation of biological process 0.8125 Least Informative Inherited
Biological Process (BP) cell differentiation 0.0000000008359 Moderately Informative Direct
Biological Process (BP) reproductive process 0.000004222 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0 Moderately Informative Direct
Biological Process (BP) signal transduction 0 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0.0000000002691 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0 Moderately Informative Direct
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0 Moderately Informative Direct
Biological Process (BP) regulation of phosphorus metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) response to external stimulus 0 Moderately Informative Direct
Biological Process (BP) nervous system development 0 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0.00000000000001071 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.00000000000006789 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.000000000004625 Moderately Informative Direct
Biological Process (BP) defense response 0.00000009175 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 0.4945 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.5078 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.5063 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.663 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) organ development 0.01301 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.3674 Moderately Informative Inherited
Biological Process (BP) tissue development 0.01023 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) single-organism organelle organization 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) oxidation-reduction process 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) response to cytokine 0 Informative Direct
Biological Process (BP) regulation of body fluid levels 0.0000000000003407 Informative Direct
Biological Process (BP) growth 0 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0.0000002606 Informative Direct
Biological Process (BP) dephosphorylation 0 Informative Direct
Biological Process (BP) generation of neurons 0 Informative Direct
Biological Process (BP) cell projection organization 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) central nervous system development 0 Informative Direct
Biological Process (BP) cellular component movement 0 Informative Direct
Biological Process (BP) regulation of apoptotic process 0 Informative Direct
Biological Process (BP) regulation of cell development 0 Informative Direct
Biological Process (BP) localization of cell 0 Informative Direct
Biological Process (BP) cellular component morphogenesis 0 Informative Direct
Biological Process (BP) biological adhesion 0 Informative Direct
Biological Process (BP) regulation of nervous system development 0.0000000000000406 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0.0000000000002789 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.000000000001434 Informative Direct
Biological Process (BP) positive regulation of developmental process 0.000000000003796 Informative Direct
Biological Process (BP) negative regulation of immune system process 0.0000000003562 Informative Direct
Biological Process (BP) blood circulation 0.000000001134 Informative Direct
Biological Process (BP) positive regulation of cellular protein metabolic process 0.000000001512 Informative Direct
Biological Process (BP) phosphorylation 0.000000002158 Informative Direct
Biological Process (BP) regulation of response to wounding 0.00000001468 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.00000002501 Informative Direct
Biological Process (BP) regulation of cell activation 0.000001088 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.0000015 Informative Direct
Biological Process (BP) regulation of locomotion 0.000001836 Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 0.000002053 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.000003559 Informative Direct
Biological Process (BP) cytoskeleton organization 0.000004894 Informative Direct
Biological Process (BP) regulation of peptidase activity 0.000006287 Informative Direct
Biological Process (BP) organelle assembly 0.00001748 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.00003558 Informative Direct
Biological Process (BP) response to bacterium 0.0000566 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0.00009748 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.0001089 Informative Direct
Biological Process (BP) sexual reproduction 0.0001193 Informative Direct
Biological Process (BP) regulation of cell proliferation 0.0001235 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0.0004689 Informative Direct
Biological Process (BP) anatomical structure homeostasis 0.0009581 Informative Direct
Biological Process (BP) regulation of immune effector process 0.0009666 Informative Direct
Biological Process (BP) positive regulation of gene expression 0.09781 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 1 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.9852 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 1 Informative Inherited
Biological Process (BP) response to organonitrogen compound 1 Informative Inherited
Biological Process (BP) cellular response to hormone stimulus 0.6693 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.5533 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) organ morphogenesis 0.2638 Informative Inherited
Biological Process (BP) tissue morphogenesis 1 Informative Inherited
Biological Process (BP) single organism reproductive process 0.1456 Informative Inherited
Biological Process (BP) reproductive structure development 1 Informative Inherited
Biological Process (BP) cation homeostasis 0.7195 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 1 Informative Inherited
Biological Process (BP) metal ion transport 1 Informative Inherited
Biological Process (BP) positive regulation of intracellular signal transduction 0.2489 Informative Inherited
Biological Process (BP) immune effector process 0.009499 Informative Inherited
Biological Process (BP) defense response to other organism 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.8077 Informative Inherited
Biological Process (BP) protein oligomerization 0.1053 Informative Inherited
Biological Process (BP) single-organism intracellular transport 1 Informative Inherited
Biological Process (BP) cytoplasmic transport 1 Informative Inherited
Biological Process (BP) neurological system process 0.5462 Informative Inherited
Biological Process (BP) synaptic transmission 1 Informative Inherited
Biological Process (BP) regulation of defense response 0.6456 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.178 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.01004 Informative Inherited
Biological Process (BP) sensory organ development 0.804 Informative Inherited
Biological Process (BP) regulation of growth 0.1913 Informative Inherited
Biological Process (BP) muscle structure development 0.009829 Informative Inherited
Biological Process (BP) single-organism membrane organization 1 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.7908 Informative Inherited
Biological Process (BP) leukocyte activation 0.1783 Informative Inherited
Biological Process (BP) regulation of transferase activity 1 Informative Inherited
Biological Process (BP) negative regulation of cell death 0.01372 Informative Inherited
Biological Process (BP) regulation of secretion 0.003738 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.2996 Informative Inherited
Biological Process (BP) regulation of vesicle-mediated transport 1 Informative Inherited
Biological Process (BP) apoptotic process 0.0126 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.08849 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.007624 Informative Inherited
Biological Process (BP) immune response 0.5248 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.02398 Informative Inherited
Biological Process (BP) cell proliferation 0.003789 Informative Inherited
Biological Process (BP) positive regulation of catabolic process 1 Informative Inherited
Biological Process (BP) regulation of cytokine production 1 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 0.03696 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.01666 Informative Inherited
Biological Process (BP) negative regulation of cellular protein metabolic process 0.7466 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 1 Informative Inherited
Biological Process (BP) actin filament-based process 0.002984 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.9175 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.5631 Informative Inherited
Biological Process (BP) embryonic morphogenesis 1 Informative Inherited
Biological Process (BP) single-organism behavior 0.2892 Informative Inherited
Biological Process (BP) gland development 0.9551 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.1796 Informative Inherited
Biological Process (BP) muscle system process 0.4983 Informative Inherited
Biological Process (BP) positive regulation of cell death 0.3544 Informative Inherited
Biological Process (BP) protein maturation 0.03876 Informative Inherited
Biological Process (BP) glycerolipid metabolic process 0.7661 Informative Inherited
Biological Process (BP) secondary metabolic process 0.6908 Informative Inherited
Biological Process (BP) pigment metabolic process 0.04675 Informative Inherited
Biological Process (BP) energy derivation by oxidation of organic compounds 1 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 1 Informative Inherited
Biological Process (BP) polysaccharide metabolic process 1 Informative Inherited
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.4057 Informative Inherited
Biological Process (BP) regulation of immune response 0.8132 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.2178 Informative Inherited
Biological Process (BP) cytokine-mediated signaling pathway 0 Highly Informative Direct
Biological Process (BP) mammary gland alveolus development 0.0004004 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 0 Highly Informative Direct
Biological Process (BP) developmental growth 0.0000000000392 Highly Informative Direct
Biological Process (BP) cell adhesion 0 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 0 Highly Informative Direct
Biological Process (BP) regulation of neuron projection development 0 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0 Highly Informative Direct
Biological Process (BP) protein phosphorylation 0 Highly Informative Direct
Biological Process (BP) protein dephosphorylation 0 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0 Highly Informative Direct
Biological Process (BP) neuron projection development 0 Highly Informative Direct
Biological Process (BP) cell growth 0 Highly Informative Direct
Biological Process (BP) chemotaxis 0 Highly Informative Direct
Biological Process (BP) cell recognition 0 Highly Informative Direct
Biological Process (BP) cell junction organization 0 Highly Informative Direct
Biological Process (BP) phagocytosis 0 Highly Informative Direct
Biological Process (BP) cell projection morphogenesis 0.0000000000001347 Highly Informative Direct
Biological Process (BP) negative regulation of immune response 0.000000000001165 Highly Informative Direct
Biological Process (BP) regulation of mononuclear cell proliferation 0.00000000008534 Highly Informative Direct
Biological Process (BP) actomyosin structure organization 0.000000000532 Highly Informative Direct
Biological Process (BP) negative regulation of neuron death 0.000000001727 Highly Informative Direct
Biological Process (BP) spermatogenesis 0.000000002467 Highly Informative Direct
Biological Process (BP) regulation of toll-like receptor signaling pathway 0.000000004852 Highly Informative Direct
Biological Process (BP) zymogen activation 0.000000007432 Highly Informative Direct
Biological Process (BP) negative regulation of response to wounding 0.00000001019 Highly Informative Direct
Biological Process (BP) regulation of adaptive immune response 0.00000001924 Highly Informative Direct
Biological Process (BP) regulation of Rho protein signal transduction 0.0000000268 Highly Informative Direct
Biological Process (BP) negative regulation of locomotion 0.00000003711 Highly Informative Direct
Biological Process (BP) regulation of neuron apoptotic process 0.0000001205 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.0000001689 Highly Informative Direct
Biological Process (BP) eye morphogenesis 0.0000003929 Highly Informative Direct
Biological Process (BP) negative regulation of cellular component movement 0.000000585 Highly Informative Direct
Biological Process (BP) regulation of peptidyl-tyrosine phosphorylation 0.000001863 Highly Informative Direct
Biological Process (BP) positive regulation of cell activation 0.00000488 Highly Informative Direct
Biological Process (BP) cellular response to peptide 0.00000645 Highly Informative Direct
Biological Process (BP) positive regulation of cellular component biogenesis 0.000006846 Highly Informative Direct
Biological Process (BP) negative regulation of response to external stimulus 0.00001069 Highly Informative Direct
Biological Process (BP) regulation of Ras GTPase activity 0.00001103 Highly Informative Direct
Biological Process (BP) coagulation 0.00002974 Highly Informative Direct
Biological Process (BP) regulation of cell size 0.00004576 Highly Informative Direct
Biological Process (BP) collagen metabolic process 0.0000471 Highly Informative Direct
Biological Process (BP) learning or memory 0.000052 Highly Informative Direct
Biological Process (BP) protein tetramerization 0.0001563 Highly Informative Direct
Biological Process (BP) energy reserve metabolic process 0.0002119 Highly Informative Direct
Biological Process (BP) inflammatory response 0.0002728 Highly Informative Direct
Biological Process (BP) positive regulation of production of molecular mediator of immune response 0.0002759 Highly Informative Direct
Biological Process (BP) ensheathment of neurons 0.0006627 Highly Informative Direct
Biological Process (BP) leukocyte proliferation 0.0008508 Highly Informative Direct
Biological Process (BP) positive regulation of apoptotic signaling pathway 0.6192 Highly Informative Inherited
Biological Process (BP) kidney development 0.2937 Highly Informative Inherited
Biological Process (BP) response to peptide hormone 0.001348 Highly Informative Inherited
Biological Process (BP) negative regulation of nervous system development 0.8599 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 1 Highly Informative Inherited
Biological Process (BP) actin filament-based movement 1 Highly Informative Inherited
Biological Process (BP) mammary gland epithelium development 0.001047 Highly Informative Inherited
Biological Process (BP) cellular calcium ion homeostasis 0.1959 Highly Informative Inherited
Biological Process (BP) response to virus 0.1008 Highly Informative Inherited
Biological Process (BP) regulation of actin cytoskeleton organization 0.001588 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.1727 Highly Informative Inherited
Biological Process (BP) calcium ion transport 0.4814 Highly Informative Inherited
Biological Process (BP) regulation of ion homeostasis 0.1196 Highly Informative Inherited
Biological Process (BP) negative regulation of homeostatic process 0.1384 Highly Informative Inherited
Biological Process (BP) sensory perception 0.06198 Highly Informative Inherited
Biological Process (BP) immune response-activating signal transduction 0.07886 Highly Informative Inherited
Biological Process (BP) immune response-regulating cell surface receptor signaling pathway 1 Highly Informative Inherited
Biological Process (BP) negative regulation of defense response 0.01138 Highly Informative Inherited
Biological Process (BP) glycosaminoglycan metabolic process 1 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.9459 Highly Informative Inherited
Biological Process (BP) positive regulation of neurogenesis 1 Highly Informative Inherited
Biological Process (BP) regulation of synaptic transmission 0.8976 Highly Informative Inherited
Biological Process (BP) cell fate commitment 1 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 0.4953 Highly Informative Inherited
Biological Process (BP) regulation of innate immune response 0.5619 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.6097 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 0.8522 Highly Informative Inherited
Biological Process (BP) response to alcohol 1 Highly Informative Inherited
Biological Process (BP) cellular component assembly involved in morphogenesis 0.005967 Highly Informative Inherited
Biological Process (BP) positive regulation of lipid metabolic process 0.13 Highly Informative Inherited
Biological Process (BP) T cell differentiation 0.7689 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 0.5786 Highly Informative Inherited
Biological Process (BP) regulation of exocytosis 0.01252 Highly Informative Inherited
Biological Process (BP) regulation of myeloid leukocyte mediated immunity 0.4354 Highly Informative Inherited
Biological Process (BP) positive regulation of endopeptidase activity 0.5162 Highly Informative Inherited
Biological Process (BP) regulation of cysteine-type endopeptidase activity involved in apoptotic process 0.001535 Highly Informative Inherited
Biological Process (BP) B cell activation 0.386 Highly Informative Inherited
Biological Process (BP) hormone-mediated signaling pathway 1 Highly Informative Inherited
Biological Process (BP) innate immune response 1 Highly Informative Inherited
Biological Process (BP) positive regulation of leukocyte proliferation 0.003031 Highly Informative Inherited
Biological Process (BP) positive regulation of GTPase activity 1 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 1 Highly Informative Inherited
Biological Process (BP) negative regulation of protein phosphorylation 0.05809 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.01255 Highly Informative Inherited
Biological Process (BP) wound healing 0.02151 Highly Informative Inherited
Biological Process (BP) hemostasis 1 Highly Informative Inherited
Biological Process (BP) cell projection assembly 0.8134 Highly Informative Inherited
Biological Process (BP) telencephalon development 0.00561 Highly Informative Inherited
Biological Process (BP) peptidyl-serine modification 1 Highly Informative Inherited
Biological Process (BP) retina development in camera-type eye 0.3353 Highly Informative Inherited
Biological Process (BP) pattern specification process 1 Highly Informative Inherited
Biological Process (BP) respiratory system development 1 Highly Informative Inherited
Biological Process (BP) acylglycerol metabolic process 0.002186 Highly Informative Inherited
Biological Process (BP) phenol-containing compound metabolic process 0.021 Highly Informative Inherited
Biological Process (BP) protein glycosylation 0.2996 Highly Informative Inherited
Biological Process (BP) regulation of humoral immune response 0.2645 Highly Informative Inherited
Biological Process (BP) positive regulation of lymphocyte mediated immunity 1 Highly Informative Inherited
Biological Process (BP) leukocyte migration 0.01342 Highly Informative Inherited
Biological Process (BP) regulation of blood pressure 0.001261 Highly Informative Inherited
Biological Process (BP) negative regulation of immune effector process 0.08074 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) transferase activity 0.000000000000007683 Least Informative Direct
Molecular Function (MF) hydrolase activity 0.9137 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) structural molecule activity 0 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 8.141e-16 Moderately Informative Direct
Molecular Function (MF) anion binding 0.00000002392 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 0.81 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 1 Moderately Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 0.007229 Moderately Informative Inherited
Molecular Function (MF) receptor activity 0 Informative Direct
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) sulfur compound binding 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0 Informative Direct
Molecular Function (MF) phosphatase activity 0 Informative Direct
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) protein dimerization activity 0.0000000000000281 Informative Direct
Molecular Function (MF) peptidase regulator activity 0.00001258 Informative Direct
Molecular Function (MF) amide binding 0.02951 Informative Inherited
Molecular Function (MF) carboxylic acid binding 0.9682 Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 1 Informative Inherited
Molecular Function (MF) enzyme activator activity 0.01322 Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 1 Informative Inherited
Molecular Function (MF) protein complex binding 0.4794 Informative Inherited
Molecular Function (MF) receptor binding 0.8128 Informative Inherited
Molecular Function (MF) transmembrane signaling receptor activity 0 Highly Informative Direct
Molecular Function (MF) phosphoprotein phosphatase activity 0 Highly Informative Direct
Molecular Function (MF) antigen binding 0 Highly Informative Direct
Molecular Function (MF) heparin binding 0 Highly Informative Direct
Molecular Function (MF) cell adhesion molecule binding 0 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0 Highly Informative Direct
Molecular Function (MF) hormone binding 0.0000004556 Highly Informative Direct
Molecular Function (MF) peptide binding 0.00001827 Highly Informative Direct
Molecular Function (MF) protein homodimerization activity 0.0001852 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0.1449 Highly Informative Inherited
Molecular Function (MF) UDP-glycosyltransferase activity 0.00292 Highly Informative Inherited
Molecular Function (MF) transferase activity, transferring hexosyl groups 0.05462 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.3947 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane part 0 Moderately Informative Direct
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) intrinsic component of membrane 0.0000000004939 Moderately Informative Direct
Cellular Component (CC) membrane region 0.09735 Moderately Informative Inherited
Cellular Component (CC) vesicle 0.0318 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.01229 Moderately Informative Inherited
Cellular Component (CC) bounding membrane of organelle 0.3664 Moderately Informative Inherited
Cellular Component (CC) cell surface 0 Informative Direct
Cellular Component (CC) extracellular matrix 0 Informative Direct
Cellular Component (CC) contractile fiber part 0 Informative Direct
Cellular Component (CC) neuron projection 0 Informative Direct
Cellular Component (CC) cell junction 0 Informative Direct
Cellular Component (CC) intrinsic component of plasma membrane 0.00000000000002026 Informative Direct
Cellular Component (CC) integral component of membrane 0.00000000000188 Informative Direct
Cellular Component (CC) cell leading edge 0.000000006496 Informative Direct
Cellular Component (CC) side of membrane 0.000001046 Informative Direct
Cellular Component (CC) extracellular membrane-bounded organelle 0.000002887 Informative Direct
Cellular Component (CC) endosome 0.00001037 Informative Direct
Cellular Component (CC) plasma membrane region 0.0001876 Informative Direct
Cellular Component (CC) extracellular space 1 Informative Inherited
Cellular Component (CC) actin cytoskeleton 1 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) proteinaceous extracellular matrix 0 Highly Informative Direct
Cellular Component (CC) extracellular matrix part 0 Highly Informative Direct
Cellular Component (CC) cell body 0 Highly Informative Direct
Cellular Component (CC) adherens junction 0 Highly Informative Direct
Cellular Component (CC) integral component of plasma membrane 0.000000000000006018 Highly Informative Direct
Cellular Component (CC) receptor complex 0.000000001293 Highly Informative Direct
Cellular Component (CC) apical plasma membrane 0.000000003708 Highly Informative Direct
Cellular Component (CC) dendrite 0.00000001824 Highly Informative Direct
Cellular Component (CC) external side of plasma membrane 0.00006579 Highly Informative Direct
Cellular Component (CC) endosomal part 0.0001295 Highly Informative Direct
Cellular Component (CC) microtubule associated complex 0.0003251 Highly Informative Direct
Cellular Component (CC) sarcomere 0.02603 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0.000000000000007826Least InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl0.00000000004277Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.1816Moderately InformativeInherited
Enzyme Commission (EC)Receptor protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0InformativeDirect
Enzyme Commission (EC)Chitinase0.0002219Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.5371Least InformativeInherited
Disease Ontology (DO)urinary system disease0.2326Moderately InformativeInherited
Disease Ontology (DO)neurodegenerative disease0.4728Moderately InformativeInherited
Disease Ontology (DO)bacterial infectious disease0.528Moderately InformativeInherited
Disease Ontology (DO)kidney failure0.07244InformativeInherited
Disease Ontology (DO)primary bacterial infectious disease0.6852InformativeInherited
Disease Ontology (DO)acute kidney failure0.00001011Highly InformativeDirect
Disease Ontology (DO)leprosy0.03017Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of skeletal physiology0.1112Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.04475Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.3333Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.698Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.7957Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.8562Least InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.006574Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.01851Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development0.2262Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.2412Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.277Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.8788Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryogenesis/ development1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal circulating cytokine level0.00001202InformativeDirect
Mammalian Phenotype (MP)abnormal cell differentiation0.01458InformativeInherited
Mammalian Phenotype (MP)abnormal female genitalia morphology0.06112InformativeInherited
Mammalian Phenotype (MP)abnormal heart layer morphology0.1291InformativeInherited
Mammalian Phenotype (MP)abnormal extraembryonic tissue morphology0.1919InformativeInherited
Mammalian Phenotype (MP)abnormal interferon level0.3547InformativeInherited
Mammalian Phenotype (MP)abnormal spermatogenesis0.6246InformativeInherited
Mammalian Phenotype (MP)abnormal axon guidance0.0004633Highly InformativeDirect
Mammalian Phenotype (MP)abnormal vagina morphology0.04557Highly InformativeInherited
Mammalian Phenotype (MP)abnormal spermiogenesis0.05745Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.02119Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.0997Least InformativeInherited
Worm Phenotype (WP)growth variant0.7352Least InformativeInherited
Worm Phenotype (WP)organ system development variant0.0000003815Moderately InformativeDirect
Worm Phenotype (WP)cell homeostasis metabolism variant0.007356Moderately InformativeInherited
Worm Phenotype (WP)locomotion variant0.00995Moderately InformativeInherited
Worm Phenotype (WP)anchor cell invasion variant0.0000000001004InformativeDirect
Worm Phenotype (WP)neuron development variant0.0000005758InformativeDirect
Worm Phenotype (WP)cell migration variant0.0005568InformativeDirect
Worm Phenotype (WP)muscle cell morphology variant0.001963InformativeInherited
Worm Phenotype (WP)activity level variant0.01276InformativeInherited
Worm Phenotype (WP)locomotor coordination variant0.01636InformativeInherited
Worm Phenotype (WP)protein metabolism variant0.04595InformativeInherited
Worm Phenotype (WP)organism stress response variant0.647InformativeInherited
Worm Phenotype (WP)muscle arm development defective0.000000007638Highly InformativeDirect
Worm Phenotype (WP)axon morphology variant0.00000002387Highly InformativeDirect
Worm Phenotype (WP)myopodia present0.00000588Highly InformativeDirect
Worm Phenotype (WP)protein degradation variant0.0001454Highly InformativeDirect
Worm Phenotype (WP)roller0.0001569Highly InformativeDirect
Worm Phenotype (WP)growth rate variant0.0008138Highly InformativeDirect
Worm Phenotype (WP)loss of asymmetry ASE0.0009604Highly InformativeDirect
Worm Phenotype (WP)axon development variant0.5179Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)cell adhesion defective0.0001605Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system subdivision0.00002941Least InformativeDirect
Fly Anatomy (FA)anatomical group0.0001758Least InformativeDirect
Fly Anatomy (FA)organ system0.002866Least InformativeInherited
Fly Anatomy (FA)adult0.0147Least InformativeInherited
Fly Anatomy (FA)larva0.02104Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.03045Least InformativeInherited
Fly Anatomy (FA)cell0.3941Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.00000002802Moderately InformativeDirect
Fly Anatomy (FA)central nervous system0.02545Moderately InformativeInherited
Fly Anatomy (FA)late embryo0.02799Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.03067Moderately InformativeInherited
Fly Anatomy (FA)neuron0.0781Moderately InformativeInherited
Fly Anatomy (FA)adult nervous system0.09945Moderately InformativeInherited
Fly Anatomy (FA)sensillum0.1311Moderately InformativeInherited
Fly Anatomy (FA)adult segment0.2111Moderately InformativeInherited
Fly Anatomy (FA)adult head0.3585Moderately InformativeInherited
Fly Anatomy (FA)tagmatic subdivision of integument0.5231Moderately InformativeInherited
Fly Anatomy (FA)adult sense organ0.5867Moderately InformativeInherited
Fly Anatomy (FA)external sensory organ0.6555Moderately InformativeInherited
Fly Anatomy (FA)adult thorax0.7616Moderately InformativeInherited
Fly Anatomy (FA)appendage0.9009Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.9454Moderately InformativeInherited
Fly Anatomy (FA)thoracic segment1Moderately InformativeInherited
Fly Anatomy (FA)commissure0.0000002559InformativeDirect
Fly Anatomy (FA)adult brain0.002182InformativeInherited
Fly Anatomy (FA)chemosensory system0.00996InformativeInherited
Fly Anatomy (FA)chaeta0.05135InformativeInherited
Fly Anatomy (FA)supraesophageal ganglion0.0533InformativeInherited
Fly Anatomy (FA)sensory organ cell0.08003InformativeInherited
Fly Anatomy (FA)leg0.2971InformativeInherited
Fly Anatomy (FA)ipsilateral tract0.7351InformativeInherited
Fly Anatomy (FA)prothoracic leg taste bristle0.0004179Highly InformativeDirect
Fly Anatomy (FA)chemosensory neuron0.005286Highly InformativeInherited
Fly Anatomy (FA)eo neuron0.07905Highly InformativeInherited

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)central nervous system0.4368Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.4811Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)hindbrain0.000131InformativeDirect
Xenopus DEvelopment stage (XDE)NF stage0.00003228Least InformativeDirect
Xenopus DEvelopment stage (XDE)embryonic stage0.00003959Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases0.0000005017Least InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosylases0.00001951Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.1718Moderately InformativeInherited
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0Highly InformativeDirect
Enzyme Commission (EC)Chitinase0.0003967Highly InformativeDirect

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)systemic hormonal preparations, excl. sex hormones and insulins0.0006913Moderately InformativeDirect
Drugbank ATC_code (DB)pituitary and hypothalamic hormones and analogues0.00002739InformativeDirect
Drugbank ATC_code (DB)immunostimulants0.0000000007379Highly InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation0Moderately InformativeDirect
Biological processCarbohydrate metabolism0.176Moderately InformativeInherited
Biological processAngiogenesis0InformativeDirect
Biological processCell adhesion0InformativeDirect
Biological processEndocytosis0InformativeDirect
Biological processNeurogenesis0InformativeDirect
Biological processHemostasis0.0000026InformativeDirect
Biological processPolysaccharide degradation0.00011InformativeDirect
Biological processChemotaxis0.0003339InformativeDirect
Biological processAcute phase0.000000000001639Highly InformativeDirect
Biological processNotch signaling pathway0.00000001263Highly InformativeDirect
Biological processBlood coagulation0.000002469Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentCytoskeleton0.00000003492Moderately InformativeDirect
Cellular componentEndosome0.00005272Moderately InformativeDirect
Cellular componentExtracellular matrix0InformativeDirect
Cellular componentGPI-anchor0InformativeDirect
Coding sequence diversityAlternative splicing0.000005817Least InformativeDirect
DiseaseDisease mutation0.00001037Least InformativeDirect
DomainRepeat0Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
DomainImmunoglobulin domain0InformativeDirect
DomainEGF-like domain0.000000000000001223InformativeDirect
DomainLeucine-rich repeat0.000000000008177InformativeDirect
DomainCollagen0.000000005983Highly InformativeDirect
Molecular functionHeparin-binding0InformativeDirect
Molecular functionCalmodulin-binding0.000001864InformativeDirect
Molecular functionActin-binding0.00001413InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationProtease1Moderately InformativeInherited
Post-translational modificationProtein phosphatase0InformativeDirect
Post-translational modificationMetalloprotease0.0007179InformativeDirect
Post-translational modificationMuscle protein0Highly InformativeDirect
Post-translational modificationTyrosine-protein kinase0Highly InformativeDirect
Post-translational modificationCytokine0.000000000000001766Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationProteoglycan0.0008778InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism6.774e-16Least InformativeDirect
UniPathway (UP)protein glycosylation0.000000004649InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR008957 SSF49265 Protein matches
Abstract

Fibronectin is composed of three repeating structural motifs, of which one is the FnIII module. The three modules form a linear sequence of multiple tandem copies connected by short linker peptides. The secondary structure of the FnIII10 module, which is the only fibronectin module to possess an integrin binding RGD motif, consists of two beta-sheets containing the antiparallel beta-strands ABE and DCFG, respectively, which fold up to form a beta-sandwich. The RGD sequence is located in the loop connecting the beta-strands [PubMed9990027].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 111 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Fibronectin type III domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 111 hidden Markov models representing the Fibronectin type III superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]