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Fibronectin type III superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Immunoglobulin-like beta-sandwich [ 48725] (28)
Superfamily:   Fibronectin type III [ 49265]
Families:   Fibronectin type III [ 49266] (44)

Superfamily statistics
Genomes (1,736) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 71,149 265,201 172
Proteins 29,622 129,837 117

Functional annotation
General category Processes_EC
Detailed category Cell adhesion

Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0.000000000000007826Least InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl0.00000000004277Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.1816Moderately InformativeInherited
Enzyme Commission (EC)Receptor protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0InformativeDirect
Enzyme Commission (EC)Chitinase0.0002219Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.5717Least InformativeInherited
Disease Ontology (DO)urinary system disease0.2508Moderately InformativeInherited
Disease Ontology (DO)neurodegenerative disease0.4839Moderately InformativeInherited
Disease Ontology (DO)disease by infectious agent0.5929Moderately InformativeInherited
Disease Ontology (DO)primary bacterial infectious disease0.7034InformativeInherited
Disease Ontology (DO)acute kidney failure0.000001647Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.007557Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.2356Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.6344Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.6531Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.9237Least InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.004741Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.02581Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.1195Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development0.159Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.2406Moderately InformativeInherited
Mammalian Phenotype (MP)reproductive system phenotype0.5306Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.8026Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal circulating cytokine level0.000002524InformativeDirect
Mammalian Phenotype (MP)autoimmune response0.0001161InformativeDirect
Mammalian Phenotype (MP)abnormal cell differentiation0.002687InformativeInherited
Mammalian Phenotype (MP)abnormal heart layer morphology0.1188InformativeInherited
Mammalian Phenotype (MP)abnormal female reproductive system physiology0.2123InformativeInherited
Mammalian Phenotype (MP)abnormal white adipose tissue morphology0.3822InformativeInherited
Mammalian Phenotype (MP)abnormal interferon level0.4741InformativeInherited
Mammalian Phenotype (MP)abnormal spermatogenesis0.6081InformativeInherited
Mammalian Phenotype (MP)increased apoptosis0.8053InformativeInherited
Mammalian Phenotype (MP)abnormal adipose tissue amount0.8321InformativeInherited
Mammalian Phenotype (MP)abnormal axon guidance0.0004421Highly InformativeDirect
Mammalian Phenotype (MP)abnormal spermiogenesis0.08906Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell morphology variant0.00001058Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.0003528Least InformativeDirect
Worm Phenotype (WP)cell development variant0.001217Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.007655Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.03904Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.1873Least InformativeInherited
Worm Phenotype (WP)nervous system morphology variant0.002388Moderately InformativeInherited
Worm Phenotype (WP)metabolic pathway variant0.002502Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.009916Moderately InformativeInherited
Worm Phenotype (WP)reproductive system development variant0.02804Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.05061Moderately InformativeInherited
Worm Phenotype (WP)cell component morphology variant1Moderately InformativeInherited
Worm Phenotype (WP)axon outgrowth variant0.00000000001721InformativeDirect
Worm Phenotype (WP)anchor cell invasion variant0.00000000005778InformativeDirect
Worm Phenotype (WP)neurite morphology variant0.000000001172InformativeDirect
Worm Phenotype (WP)locomotion reduced0.000005532InformativeDirect
Worm Phenotype (WP)protein degradation variant0.000005644InformativeDirect
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.00005115InformativeDirect
Worm Phenotype (WP)body posture variant0.0002833InformativeDirect
Worm Phenotype (WP)mitochondria morphology variant0.000341InformativeDirect
Worm Phenotype (WP)locomotor coordination variant0.002132InformativeInherited
Worm Phenotype (WP)muscle cell physiology variant0.004537InformativeInherited
Worm Phenotype (WP)forward locomotion variant0.03091InformativeInherited
Worm Phenotype (WP)muscle arm development defective0.000000005148Highly InformativeDirect
Worm Phenotype (WP)forward locomotion decreased0.00004121Highly InformativeDirect
Worm Phenotype (WP)axon trajectory variant0.0259Highly InformativeInherited
Worm Phenotype (WP)loss of left right asymmetry0.09566Highly InformativeInherited
Worm Phenotype (WP)neuronal cell fate specification variant0.2102Highly InformativeInherited
Worm Phenotype (WP)path curvature variant0.7277Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system subdivision0.000642Least InformativeDirect
Fly Anatomy (FA)nervous system0.01245Least InformativeInherited
Fly Anatomy (FA)larva0.01611Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.04908Least InformativeInherited
Fly Anatomy (FA)adult0.17Least InformativeInherited
Fly Anatomy (FA)somatic cell0.3143Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.000000002793Moderately InformativeDirect
Fly Anatomy (FA)ganglion0.00299Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.0075Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.01756Moderately InformativeInherited
Fly Anatomy (FA)late embryo0.07023Moderately InformativeInherited
Fly Anatomy (FA)sensory system0.09391Moderately InformativeInherited
Fly Anatomy (FA)adult segment0.1662Moderately InformativeInherited
Fly Anatomy (FA)adult nervous system0.218Moderately InformativeInherited
Fly Anatomy (FA)neuron0.249Moderately InformativeInherited
Fly Anatomy (FA)somatic precursor cell0.6186Moderately InformativeInherited
Fly Anatomy (FA)head0.6958Moderately InformativeInherited
Fly Anatomy (FA)larval abdomen0.0000007126InformativeDirect
Fly Anatomy (FA)primordium0.01833InformativeInherited
Fly Anatomy (FA)adult procephalic segment0.01957InformativeInherited
Fly Anatomy (FA)chemosensory system0.04044InformativeInherited
Fly Anatomy (FA)labral segment0.04404InformativeInherited
Fly Anatomy (FA)brain0.04888InformativeInherited
Fly Anatomy (FA)neuromere0.09753InformativeInherited
Fly Anatomy (FA)dorsal closure embryo0.1205InformativeInherited
Fly Anatomy (FA)adult central nervous system0.1383InformativeInherited
Fly Anatomy (FA)tract0.3991InformativeInherited
Fly Anatomy (FA)synaptic neuropil domain0.4257InformativeInherited
Fly Anatomy (FA)leg taste bristle chemosensory neuron0.00001218Highly InformativeDirect
Fly Anatomy (FA)commissure0.00002226Highly InformativeDirect
Fly Anatomy (FA)embryonic heart cardioblast0.00003206Highly InformativeDirect
Fly Anatomy (FA)LNv neuron0.0001367Highly InformativeDirect
Fly Anatomy (FA)lobe system of adult mushroom body0.0001486Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)multi-tissue structure0.1582Least InformativeInherited
Zebrafish Anatomy (ZA)compound organ0.171Least InformativeInherited
Zebrafish Anatomy (ZA)nervous system0.6216Least InformativeInherited
Zebrafish Anatomy (ZA)central nervous system0.2789Moderately InformativeInherited
Zebrafish Anatomy (ZA)sensory system0.7006Moderately InformativeInherited
Zebrafish Anatomy (ZA)forebrain0.03375InformativeInherited
Zebrafish Anatomy (ZA)medial longitudinal fasciculus0.00001896Highly InformativeDirect
Zebrafish Anatomy (ZA)glomerular layer0.0003196Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)head0.9182Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.9765Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical system1Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue1Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.0794Moderately InformativeInherited
Xenopus ANatomical entity (XAN)sensory system0.2476Moderately InformativeInherited
Xenopus ANatomical entity (XAN)eye0.2732InformativeInherited
Xenopus ANatomical entity (XAN)retinal neural layer0.002012Highly InformativeInherited
Xenopus DEvelopment stage (XDE)embryonic stage0.000002288Moderately InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases0.0000007659Least InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Aminoacyltransferases0.000001008Moderately InformativeDirect
Enzyme Commission (EC)Glycosylases0.0000673Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.1418Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases0.8019Moderately InformativeInherited
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0InformativeDirect
Enzyme Commission (EC)RING-type E3 ubiquitin transferase0.0000000008284InformativeDirect
Enzyme Commission (EC)Hexosyltransferases0.00001868InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0Highly InformativeDirect
Enzyme Commission (EC)Chitinase0.0006827Highly InformativeDirect

Document: EC annotation of SCOP domains

InterPro annotation
Cross references IPR008957 SSF49265 Protein matches

Fibronectin is composed of three repeating structural motifs, of which one is the FnIII module. The three modules form a linear sequence of multiple tandem copies connected by short linker peptides. The secondary structure of the FnIII10 module, which is the only fibronectin module to possess an integrin binding RGD motif, consists of two beta-sheets containing the antiparallel beta-strands ABE and DCFG, respectively, which fold up to form a beta-sandwich. The RGD sequence is located in the loop connecting the beta-strands [PubMed9990027].

InterPro database

PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 169 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Browse and view proteins in genomes which have different domain combinations including a Fibronectin type III domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 169 hidden Markov models representing the Fibronectin type III superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]