SUPERFAMILY 1.75 HMM library and genome assignments server

Transglutaminase, two C-terminal domains superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Immunoglobulin-like beta-sandwich [ 48725] (28)
Superfamily:   Transglutaminase, two C-terminal domains [ 49309]
Families:   Transglutaminase, two C-terminal domains [ 49310]


Superfamily statistics
Genomes (150) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 1,570 1,723 16
Proteins 832 931 8


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 0.0000000001435 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.0000001689 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.00002774 Least Informative Direct
Biological Process (BP) response to stimulus 0.1898 Least Informative Inherited
Biological Process (BP) developmental process 0.02281 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.01334 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) regulation of biological quality 0.0000000005115 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.0000002258 Moderately Informative Direct
Biological Process (BP) organ development 0.00009782 Moderately Informative Direct
Biological Process (BP) immune system process 0.000119 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.02278 Moderately Informative Inherited
Biological Process (BP) cation homeostasis 0.00000000000946 Informative Direct
Biological Process (BP) regulation of body fluid levels 0.000001994 Informative Direct
Biological Process (BP) hematopoietic or lymphoid organ development 0.00006274 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.007721 Informative Inherited
Biological Process (BP) hemostasis 0.00000000005798 Highly Informative Direct
Biological Process (BP) wound healing 0.000000005578 Highly Informative Direct
Biological Process (BP) coagulation 0.0000001096 Highly Informative Direct
Biological Process (BP) transition metal ion homeostasis 0.06706 Highly Informative Inherited
Molecular Function (MF) transferase activity 0.00000001103 Least Informative Direct
Molecular Function (MF) binding 0.6043 Least Informative Inherited
Molecular Function (MF) cation binding 0.2376 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 8.141e-16 Informative Direct
Molecular Function (MF) transferase activity, transferring amino-acyl groups 0 Highly Informative Direct
Molecular Function (MF) calcium ion binding 0.0000002978 Highly Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0.008194 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.3159 Least Informative Inherited
Cellular Component (CC) cytoskeleton 0.00000537 Moderately Informative Direct
Cellular Component (CC) cell cortex 0.000000719 Informative Direct
Cellular Component (CC) cortical cytoskeleton 0.000002958 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Aminoacyltransferases0InformativeDirect
Enzyme Commission (EC)Protein-glutamine gamma-glutamyltransferase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.006215Least InformativeInherited
Disease Ontology (DO)skin disease0.00002629Moderately InformativeDirect
Disease Ontology (DO)hypersensitivity reaction type II disease0.01681Moderately InformativeInherited
Disease Ontology (DO)dermatitis herpetiformis0.000000003121InformativeDirect

Document: DO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Aminoacyltransferases0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
DiseaseDisease mutation0.00000005025Least InformativeDirect
Molecular functionMetal-binding0.000000000000001378Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationAcyltransferase0InformativeDirect
Post-translational modificationZymogen0.000006165InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR008958 SSF49309 Protein matches
Abstract

Synonym(s): Protein-glutamine gamma-glutamyltransferase, Fibrinoligase, TGase

Transglutaminases catalyse the post-translational modification of proteins at glutamine residues, with formation of isopeptide bonds. Members of the transglutaminase family usually have three domains: N-terminal , middle and C-terminal. The middle domain is usually well conserved, but family members can display major differences in their N- and C-terminal domains, although their overall structure is conserved [PubMed10411627]. This entry represents the C-terminal domain found in transglutaminases, which consists of an immunoglobulin-like beta-sandwich consisting of seven strands in two sheets with a Greek key topology.

The best known transglutaminase is blood coagulation factor XIII, a plasma tetrameric protein composed of two catalytic A subunits and two non-catalytic B subunits. Factor XIII is responsible for cross-linking fibrin chains, thus stabilizing the fibrin clot. Protein-glutamine gamma-glutamyltransferases are calcium-dependent enzymes that catalyse the cross-linking of proteins by promoting the formation of isopeptide bonds between the gamma-carboxyl group of a glutamine in one polypeptide chain and the epsilon-amino group of a lysine in a second polypeptide chain. TGases also catalyse the conjugation of polyamines to proteins [PubMed1683845, PubMed1974250].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 8 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Transglutaminase, two C-terminal domains domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 8 hidden Markov models representing the Transglutaminase, two C-terminal domains superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]