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Transglutaminase, two C-terminal domains superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Immunoglobulin-like beta-sandwich [ 48725] (28)
Superfamily:   Transglutaminase, two C-terminal domains [ 49309]
Families:   Transglutaminase, two C-terminal domains [ 49310]


Superfamily statistics
Genomes (150) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 1,553 1,723 16
Proteins 824 931 8


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biological regulation 0.03436 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 0.001156 Least Informative Inherited
Biological Process (BP) response to stimulus 0.4484 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.1249 Least Informative Inherited
Biological Process (BP) cellular protein modification process 0.000002718 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.001427 Moderately Informative Inherited
Biological Process (BP) response to stress 0.1971 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.01728 Moderately Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.00001932 Informative Direct
Biological Process (BP) ion homeostasis 0.00001762 Informative Direct
Biological Process (BP) regulation of cell cycle 0.0003261 Informative Direct
Biological Process (BP) hemostasis 0.000000008242 Highly Informative Direct
Biological Process (BP) wound healing 0.000002371 Highly Informative Direct
Biological Process (BP) coagulation 0.0000002691 Highly Informative Direct
Biological Process (BP) regulation of epithelial cell proliferation 0.002081 Highly Informative Inherited
Molecular Function (MF) transferase activity 0.00000000001421 Least Informative Direct
Molecular Function (MF) binding 0.6375 Least Informative Inherited
Molecular Function (MF) metal ion binding 0.0007455 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 0 Informative Direct
Molecular Function (MF) calcium ion binding 0.0000005964 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Aminoacyltransferases0InformativeDirect
Enzyme Commission (EC)Protein-glutamine gamma-glutamyltransferase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.007094Least InformativeInherited
Disease Ontology (DO)skin disease0.000002513Moderately InformativeDirect
Disease Ontology (DO)hypersensitivity reaction type II disease0.003877Moderately InformativeInherited
Disease Ontology (DO)autoimmune disease of skin and connective tissue0.000000007289InformativeDirect
Disease Ontology (DO)bullous skin disease0.00000003116InformativeDirect

Document: DO annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus DEvelopment stage (XDE)embryonic stage0Least InformativeDirect
Xenopus DEvelopment stage (XDE)NF stage0Least InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Aminoacyltransferases0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
DiseaseDisease mutation0.0000001068Least InformativeDirect
Molecular functionMetal-binding0.000000000000003697Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationAcyltransferase0InformativeDirect
Post-translational modificationZymogen0.000004683InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR008958 SSF49309 Protein matches
Abstract

Synonym(s): Protein-glutamine gamma-glutamyltransferase, Fibrinoligase, TGase

Transglutaminases catalyse the post-translational modification of proteins at glutamine residues, with formation of isopeptide bonds. Members of the transglutaminase family usually have three domains: N-terminal , middle and C-terminal. The middle domain is usually well conserved, but family members can display major differences in their N- and C-terminal domains, although their overall structure is conserved [PubMed10411627]. This entry represents the C-terminal domain found in transglutaminases, which consists of an immunoglobulin-like beta-sandwich consisting of seven strands in two sheets with a Greek key topology.

The best known transglutaminase is blood coagulation factor XIII, a plasma tetrameric protein composed of two catalytic A subunits and two non-catalytic B subunits. Factor XIII is responsible for cross-linking fibrin chains, thus stabilizing the fibrin clot. Protein-glutamine gamma-glutamyltransferases are calcium-dependent enzymes that catalyse the cross-linking of proteins by promoting the formation of isopeptide bonds between the gamma-carboxyl group of a glutamine in one polypeptide chain and the epsilon-amino group of a lysine in a second polypeptide chain. TGases also catalyse the conjugation of polyamines to proteins [PubMed1683845, PubMed1974250].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 8 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Transglutaminase, two C-terminal domains domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 8 hidden Markov models representing the Transglutaminase, two C-terminal domains superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]