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Clathrin adaptor appendage domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Immunoglobulin-like beta-sandwich [ 48725] (28)
Superfamily:   Clathrin adaptor appendage domain [ 49348] (3)
Families:   Alpha-adaptin ear subdomain-like [ 49349] (2)
  gamma-adaptin C-terminal appendage domain-like [ 74857] (3)
  Coatomer appendage domain [ 101536]


Superfamily statistics
Genomes (515) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 3,246 7,920 16
Proteins 3,242 7,894 16


Functional annotation
General category Processes_IC
Detailed category Transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0.0335 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.01434 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.88 Least Informative Inherited
Biological Process (BP) cellular localization 0.0001122 Moderately Informative Direct
Biological Process (BP) animal organ development 0.2366 Moderately Informative Inherited
Biological Process (BP) nitrogen compound transport 0.01174 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.3244 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.2098 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.00331 Moderately Informative Inherited
Biological Process (BP) immune system process 0.01119 Moderately Informative Inherited
Biological Process (BP) protein transport 0 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.00000000000001254 Informative Direct
Biological Process (BP) intracellular transport 0.0000004843 Informative Direct
Biological Process (BP) microtubule-based process 0.000001608 Informative Direct
Biological Process (BP) organelle localization 0.5542 Informative Inherited
Biological Process (BP) interspecies interaction between organisms 0.007308 Informative Inherited
Biological Process (BP) movement of cell or subcellular component 0.03849 Informative Inherited
Biological Process (BP) vesicle organization 0.0000000171 Highly Informative Direct
Biological Process (BP) microtubule-based movement 0.000001019 Highly Informative Direct
Biological Process (BP) viral process 0.00002787 Highly Informative Direct
Biological Process (BP) establishment of organelle localization 0.07332 Highly Informative Inherited
Biological Process (BP) Golgi vesicle transport 0.01256 Highly Informative Inherited
Molecular Function (MF) binding 0.0005357 Least Informative Direct
Molecular Function (MF) transporter activity 0.000004743 Moderately Informative Direct
Molecular Function (MF) enzyme binding 0.007296 Informative Inherited
Molecular Function (MF) protein transporter activity 0 Highly Informative Direct
Molecular Function (MF) kinase binding 0.03881 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 0 Least Informative Direct
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) protein complex 0.00000001528 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.00000001552 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.6973 Least Informative Inherited
Cellular Component (CC) vesicle 0 Moderately Informative Direct
Cellular Component (CC) membrane protein complex 0 Moderately Informative Direct
Cellular Component (CC) whole membrane 0 Moderately Informative Direct
Cellular Component (CC) endomembrane system 0 Moderately Informative Direct
Cellular Component (CC) bounding membrane of organelle 0 Moderately Informative Direct
Cellular Component (CC) vacuole 0.02039 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 0.04764 Moderately Informative Inherited
Cellular Component (CC) Golgi apparatus 0 Informative Direct
Cellular Component (CC) cytoplasmic vesicle part 0 Informative Direct
Cellular Component (CC) membrane region 0.00000000009883 Informative Direct
Cellular Component (CC) plasma membrane protein complex 0.000007835 Informative Direct
Cellular Component (CC) lytic vacuole 0.05849 Informative Inherited
Cellular Component (CC) vacuolar part 0.006302 Informative Inherited
Cellular Component (CC) membrane coat 0 Highly Informative Direct
Cellular Component (CC) coated vesicle 0 Highly Informative Direct
Cellular Component (CC) Golgi-associated vesicle 0.00000000004818 Highly Informative Direct
Cellular Component (CC) cytoplasmic vesicle membrane 0.00000006107 Highly Informative Direct
Cellular Component (CC) lysosomal membrane 0.000000122 Highly Informative Direct
Cellular Component (CC) endocytic vesicle 0.00442 Highly Informative Inherited
Cellular Component (CC) Golgi subcompartment 0.009427 Highly Informative Inherited

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processProtein transport0Moderately InformativeDirect
Biological processEndocytosis0InformativeDirect
Biological processER-Golgi transport0Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentGolgi apparatus0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0Moderately InformativeDirect
Cellular componentEndosome0.0000000008511Moderately InformativeDirect
Cellular componentCoated pit0Highly InformativeDirect
DomainRepeat0.00000000000001391Least InformativeDirect
Molecular functionLipid-binding0.000000003196Moderately InformativeDirect
Post-translational modificationPhosphoprotein0.000001955Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR013041 SSF49348 Protein matches
Abstract

This entry represents a beta-sandwich structural motif found in the appendage (ear) domain of alpha-, beta- and gamma-adaptin from AP clathrin adaptor complexes, the GAE (gamma-adaptin ear) domain of GGA adaptor proteins, and the appendage domain of the gamma subunit of coatomer complexes. These domains have an immunoglobulin-like beta-sandwich fold containing 7 or 8 strands in 2 beta-sheets in a Greek key topology [PubMed12042876, PubMed12808037, PubMed14527408]. Although the appendage domains from AP / GGA adaptins and coatomers share a similar fold, there is little sequence identity between them. However, they also share similar motif-based cargo recognition and accessory factor recruitment mechanisms.

More information about these proteins can be found at Protein of the Month: Clathrin.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 8 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Clathrin adaptor appendage domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 8 hidden Markov models representing the Clathrin adaptor appendage domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]