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Bacterial adhesins superfamily
|General category ||Processes_EC|
|Detailed category ||Cell adhesion|
Document: Function annotation of SCOP domain superfamilies
|Cross references ||IPR008966 SSF49401 Protein matches|
The bacterial adhesion domain is found in adhesin proteins, which form part of the adhesive pilus found on the cell surface. Adhesin proteins are important for receptor binding to host cells during pathogenesis. For example, the Escherichia coli PapG adhesin at the tip of the P pilus is necessary for attachment to the human kidney receptor during pyelonephritis pathogenesis . The bacterial adhesion domain consists of a beta-sandwich formed of 9 strands in 2 sheets with a Greek-key topology and is a sub-class of the immunoglobin-like fold. Members of this structural superfamily include:
- Collagen-binding domain of adhesion .
- Fibrinogen-binding domain, which is found in both fibrinogen-binding adhesion SdrG and in clumping factor A; these proteins contain a duplication of this domain, where each copy of this fold displays a variation in the core structure .
- Pilus subunits, such as mannose-specific adhesion FimH (duplication of this domain), PapK pilus subunit (similar to C-terminal domain of FimH), PapE pilus subunit, and F1 capsule antigen Caf1 .
- PapG adhesion receptor-binding domain .
- F17c-type adhesions, such as fimbrail adhesion F17-AG lectin domain, and fimbrial lectin GafD .
- Dr-family adhesion Afa-III .
PDBeMotif information about ligands, sequence and structure motifs
Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation ]
Internal database links
Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry
out SCOP domain assignments to all genomes at the superfamily level.
Alignments of sequences to 28 models
in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical
are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.
Browse and view proteins in genomes which have
different domain combinations including a Bacterial adhesins domain.
Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.
Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.
There are 28 hidden Markov models representing the Bacterial adhesins superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.
Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Internal database links ]