p53-like transcription factors superfamily

SCOP classification

Root:	SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:	All beta proteins [ 48724] (174)
Fold:	Common fold of diphtheria toxin/transcription factors/cytochrome f [ 49379] (10)
Superfamily:	p53-like transcription factors [ 49417] (7)
Families:	p53 DNA-binding domain-like [ 81314] (2)
	Rel/Dorsal transcription factors, DNA-binding domain [ 81315] (6)
	T-box [ 81316] (2)
	STAT DNA-binding domain [ 81317] (3)
	RUNT domain [ 81318]
	DNA-binding domain from NDT80 [ 81992]
	DNA-binding protein LAG-1 (CSL) [ 110080]

Superfamily statistics

	Genomes (367)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	6,320	0	53
Proteins	6,210	0	53

Functional annotation

General category	Regulation
Detailed category	DNA-binding

Document: Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details)

	DO term	FDR (all)	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	organ system cancer	0.1037	Least Informative	Inherited
Disease Ontology (DO)	hematologic cancer	0.00143	Moderately Informative	Inherited
Disease Ontology (DO)	disease by infectious agent	0.00476	Moderately Informative	Inherited
Disease Ontology (DO)	gastrointestinal system disease	0.01038	Moderately Informative	Inherited
Disease Ontology (DO)	benign neoplasm	0.02442	Moderately Informative	Inherited
Disease Ontology (DO)	head and neck carcinoma	0.0000002741	Informative	Direct
Disease Ontology (DO)	inflammatory bowel disease	0.000002613	Informative	Direct
Disease Ontology (DO)	connective tissue cancer	0.0000925	Informative	Direct
Disease Ontology (DO)	physical disorder	0.001181	Informative	Inherited
Disease Ontology (DO)	lymphoma	0.007253	Informative	Inherited
Disease Ontology (DO)	breast cancer	0.008725	Informative	Inherited
Disease Ontology (DO)	cell type benign neoplasm	0.01084	Informative	Inherited
Disease Ontology (DO)	respiratory system cancer	0.1013	Informative	Inherited
Disease Ontology (DO)	viral infectious disease	0.2662	Informative	Inherited
Disease Ontology (DO)	colitis	0.00000008629	Highly Informative	Direct
Disease Ontology (DO)	Burkitt lymphoma	0.00002689	Highly Informative	Direct
Disease Ontology (DO)	mumps	0.00006567	Highly Informative	Direct
Disease Ontology (DO)	Barrett's esophagus	0.00007215	Highly Informative	Direct
Disease Ontology (DO)	gastritis	0.0002477	Highly Informative	Direct
Disease Ontology (DO)	chronic leukemia	0.0003982	Highly Informative	Direct
Disease Ontology (DO)	pertussis	0.0004111	Highly Informative	Direct
Disease Ontology (DO)	progressive multifocal leukoencephalopathy	0.0005128	Highly Informative	Direct
Disease Ontology (DO)	laryngeal carcinoma	0.0005345	Highly Informative	Direct
Disease Ontology (DO)	hemangioma	0.0005531	Highly Informative	Direct
Disease Ontology (DO)	salivary gland adenoid cystic carcinoma	0.0007319	Highly Informative	Direct
Disease Ontology (DO)	large intestine cancer	0.007557	Highly Informative	Inherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)

	HP term	FDR (all)	SDHP level	Annotation (direct or inherited)
Phenotypic Abnormality (PA)	Abnormality of the skeletal system	0.08514	Least Informative	Inherited
Phenotypic Abnormality (PA)	Abnormality of the head	0.1874	Least Informative	Inherited
Phenotypic Abnormality (PA)	Abnormality of limbs	0.2941	Least Informative	Inherited
Phenotypic Abnormality (PA)	Abnormality of limb bone morphology	0.06563	Moderately Informative	Inherited
Phenotypic Abnormality (PA)	Abnormality of the upper limb	0.1226	Moderately Informative	Inherited
Phenotypic Abnormality (PA)	Neoplasm	0.1467	Moderately Informative	Inherited
Phenotypic Abnormality (PA)	Abnormality of blood and blood-forming tissues	0.1893	Moderately Informative	Inherited
Phenotypic Abnormality (PA)	Aplasia/hypoplasia of the extremities	0.01635	Informative	Inherited
Phenotypic Abnormality (PA)	Abnormality of the thorax	0.2767	Informative	Inherited
Phenotypic Abnormality (PA)	Lymphoma	0.0003856	Highly Informative	Direct
Phenotypic Abnormality (PA)	Abnormality of the scapula	0.01303	Highly Informative	Inherited
Phenotypic Abnormality (PA)	Aplasia/Hypoplasia involving bones of the thorax	0.03148	Highly Informative	Inherited
Phenotypic Abnormality (PA)	Aplasia/hypoplasia involving bones of the hand	0.214	Highly Informative	Inherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)

	MP term	FDR (all)	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	growth/size/body region phenotype	0.000001618	Least Informative	Direct
Mammalian Phenotype (MP)	mortality/aging	0.000002057	Least Informative	Direct
Mammalian Phenotype (MP)	cellular phenotype	0.0002043	Least Informative	Direct
Mammalian Phenotype (MP)	cardiovascular system phenotype	0.0003428	Least Informative	Direct
Mammalian Phenotype (MP)	hematopoietic system phenotype	0.006138	Least Informative	Inherited
Mammalian Phenotype (MP)	immune system phenotype	0.007601	Least Informative	Inherited
Mammalian Phenotype (MP)	nervous system phenotype	0.02695	Least Informative	Inherited
Mammalian Phenotype (MP)	abnormal homeostasis	0.1979	Least Informative	Inherited
Mammalian Phenotype (MP)	abnormal blood cell morphology/development	0.000000009932	Moderately Informative	Direct
Mammalian Phenotype (MP)	abnormal leukocyte physiology	0.0000005047	Moderately Informative	Direct
Mammalian Phenotype (MP)	abnormal skeleton morphology	0.0000008249	Moderately Informative	Direct
Mammalian Phenotype (MP)	integument phenotype	0.000001224	Moderately Informative	Direct
Mammalian Phenotype (MP)	embryo phenotype	0.000001855	Moderately Informative	Direct
Mammalian Phenotype (MP)	respiratory system phenotype	0.000005462	Moderately Informative	Direct
Mammalian Phenotype (MP)	abnormal craniofacial morphology	0.000009344	Moderately Informative	Direct
Mammalian Phenotype (MP)	abnormal gland morphology	0.000009671	Moderately Informative	Direct
Mammalian Phenotype (MP)	abnormal mononuclear cell morphology	0.0000288	Moderately Informative	Direct
Mammalian Phenotype (MP)	limbs/digits/tail phenotype	0.00005805	Moderately Informative	Direct
Mammalian Phenotype (MP)	abnormal blood cell morphology	0.00008736	Moderately Informative	Direct
Mammalian Phenotype (MP)	liver/biliary system phenotype	0.0008538	Moderately Informative	Direct
Mammalian Phenotype (MP)	abnormal inflammatory response	0.001447	Moderately Informative	Inherited
Mammalian Phenotype (MP)	abnormal immune serum protein physiology	0.003599	Moderately Informative	Inherited
Mammalian Phenotype (MP)	abnormal cell death	0.005896	Moderately Informative	Inherited
Mammalian Phenotype (MP)	abnormal cardiovascular system physiology	0.01523	Moderately Informative	Inherited
Mammalian Phenotype (MP)	abnormal immune system organ morphology	0.02008	Moderately Informative	Inherited
Mammalian Phenotype (MP)	abnormal hematopoietic cell number	0.03062	Moderately Informative	Inherited
Mammalian Phenotype (MP)	neoplasm	0.03181	Moderately Informative	Inherited
Mammalian Phenotype (MP)	abnormal blood vessel morphology	0.03402	Moderately Informative	Inherited
Mammalian Phenotype (MP)	abnormal myeloid cell morphology	0.04819	Moderately Informative	Inherited
Mammalian Phenotype (MP)	abnormal heart morphology	0.05444	Moderately Informative	Inherited
Mammalian Phenotype (MP)	lethality during fetal growth through weaning	0.05862	Moderately Informative	Inherited
Mammalian Phenotype (MP)	prenatal lethality	0.08278	Moderately Informative	Inherited
Mammalian Phenotype (MP)	abnormal digestive system morphology	0.1005	Moderately Informative	Inherited
Mammalian Phenotype (MP)	abnormal protein level	0.1334	Moderately Informative	Inherited
Mammalian Phenotype (MP)	abnormal professional antigen presenting cell physiology	0.4832	Moderately Informative	Inherited
Mammalian Phenotype (MP)	altered susceptibility to infection	0.5429	Moderately Informative	Inherited
Mammalian Phenotype (MP)	abnormal hormone level	0.7244	Moderately Informative	Inherited
Mammalian Phenotype (MP)	abnormal behavior	1	Moderately Informative	Inherited
Mammalian Phenotype (MP)	abnormal interleukin level	0.00000001081	Informative	Direct
Mammalian Phenotype (MP)	increased susceptibility to infection	0.00000031	Informative	Direct
Mammalian Phenotype (MP)	abnormal liver physiology	0.000003222	Informative	Direct
Mammalian Phenotype (MP)	abnormal thymus morphology	0.00001349	Informative	Direct
Mammalian Phenotype (MP)	abnormal coat appearance	0.00001997	Informative	Direct
Mammalian Phenotype (MP)	abnormal T cell differentiation	0.00003041	Informative	Direct
Mammalian Phenotype (MP)	abnormal fluid regulation	0.0000474	Informative	Direct
Mammalian Phenotype (MP)	normal phenotype	0.00006735	Informative	Direct
Mammalian Phenotype (MP)	abnormal B cell proliferation	0.0001198	Informative	Direct
Mammalian Phenotype (MP)	hemorrhage	0.0001364	Informative	Direct
Mammalian Phenotype (MP)	altered tumor pathology	0.0003108	Informative	Direct
Mammalian Phenotype (MP)	increased leukocyte cell number	0.0004406	Informative	Direct
Mammalian Phenotype (MP)	abnormal cartilage morphology	0.002063	Informative	Inherited
Mammalian Phenotype (MP)	abnormal humoral immune response	0.003872	Informative	Inherited
Mammalian Phenotype (MP)	abnormal adaptive thermogenesis	0.004066	Informative	Inherited
Mammalian Phenotype (MP)	abnormal spinal cord morphology	0.00887	Informative	Inherited
Mammalian Phenotype (MP)	abnormal epidermal layer morphology	0.0102	Informative	Inherited
Mammalian Phenotype (MP)	abnormal circulating cytokine level	0.01193	Informative	Inherited
Mammalian Phenotype (MP)	abnormal gland physiology	0.02271	Informative	Inherited
Mammalian Phenotype (MP)	abnormal B lymphocyte antigen presentation	0.02865	Informative	Inherited
Mammalian Phenotype (MP)	abnormal lymph node morphology	0.04133	Informative	Inherited
Mammalian Phenotype (MP)	abnormal head morphology	0.04139	Informative	Inherited
Mammalian Phenotype (MP)	abnormal interferon level	0.07153	Informative	Inherited
Mammalian Phenotype (MP)	abnormal mammary gland morphology	0.07609	Informative	Inherited
Mammalian Phenotype (MP)	abnormal appendicular skeleton morphology	0.08045	Informative	Inherited
Mammalian Phenotype (MP)	abnormal thoracic cage morphology	0.2411	Informative	Inherited
Mammalian Phenotype (MP)	abnormal natural killer cell mediated cytotoxicity	0.2424	Informative	Inherited
Mammalian Phenotype (MP)	abnormal stomach morphology	0.3271	Informative	Inherited
Mammalian Phenotype (MP)	increased hemolymphoid system tumor incidence	0.3509	Informative	Inherited
Mammalian Phenotype (MP)	increased carcinoma incidence	0.3809	Informative	Inherited
Mammalian Phenotype (MP)	abnormal voluntary movement	0.4858	Informative	Inherited
Mammalian Phenotype (MP)	abnormal erythroid lineage cell morphology	0.5392	Informative	Inherited
Mammalian Phenotype (MP)	abnormal vertebrae morphology	0.6966	Informative	Inherited
Mammalian Phenotype (MP)	abnormal Peyer's patch morphology	0.8936	Informative	Inherited
Mammalian Phenotype (MP)	decreased B cell proliferation	0.000006255	Highly Informative	Direct
Mammalian Phenotype (MP)	abnormal mammary gland epithelium physiology	0.000009155	Highly Informative	Direct
Mammalian Phenotype (MP)	respiratory system inflammation	0.000009671	Highly Informative	Direct
Mammalian Phenotype (MP)	lethality throughout fetal growth and development, complete penetrance	0.00002662	Highly Informative	Direct
Mammalian Phenotype (MP)	abnormal secondary palate development	0.000061	Highly Informative	Direct
Mammalian Phenotype (MP)	abnormal intervertebral disk morphology	0.0001114	Highly Informative	Direct
Mammalian Phenotype (MP)	impaired adaptive thermogenesis	0.0001292	Highly Informative	Direct
Mammalian Phenotype (MP)	decreased dendritic cell number	0.0001311	Highly Informative	Direct
Mammalian Phenotype (MP)	abnormal cervical atlas morphology	0.0001414	Highly Informative	Direct
Mammalian Phenotype (MP)	abnormal stomach epithelium morphology	0.0001709	Highly Informative	Direct
Mammalian Phenotype (MP)	cleft palate	0.0002133	Highly Informative	Direct
Mammalian Phenotype (MP)	abnormal level of surface class II molecules	0.0002753	Highly Informative	Direct
Mammalian Phenotype (MP)	abnormal thymus medulla morphology	0.0003095	Highly Informative	Direct
Mammalian Phenotype (MP)	abnormal heart development	0.0003211	Highly Informative	Direct
Mammalian Phenotype (MP)	abnormal circulating insulin-like growth factor I level	0.0005464	Highly Informative	Direct
Mammalian Phenotype (MP)	increased adenocarcinoma incidence	0.0006237	Highly Informative	Direct
Mammalian Phenotype (MP)	abnormal granulocyte number	0.0006578	Highly Informative	Direct
Mammalian Phenotype (MP)	abnormal vertebral arch morphology	0.0008301	Highly Informative	Direct
Mammalian Phenotype (MP)	abnormal mammary gland alveolus morphology	0.0008657	Highly Informative	Direct
Mammalian Phenotype (MP)	abnormal spinal cord white matter morphology	0.008986	Highly Informative	Inherited
Mammalian Phenotype (MP)	abnormal IgG2a level	0.01026	Highly Informative	Inherited
Mammalian Phenotype (MP)	abnormal head movements	0.01288	Highly Informative	Inherited
Mammalian Phenotype (MP)	increased leukemia incidence	0.01364	Highly Informative	Inherited
Mammalian Phenotype (MP)	abnormal bone marrow cell morphology/development	0.01871	Highly Informative	Inherited
Mammalian Phenotype (MP)	embryonic lethality during organogenesis	0.06056	Highly Informative	Inherited
Mammalian Phenotype (MP)	abnormal Peyer's patch size	0.1245	Highly Informative	Inherited
Mammalian Phenotype (MP)	abnormal peripheral lymph node morphology	0.1484	Highly Informative	Inherited
Mammalian Phenotype (MP)	abnormal epidermis stratum spinosum morphology	0.219	Highly Informative	Inherited
Mammalian Phenotype (MP)	abnormal neurocranium morphology	0.2655	Highly Informative	Inherited
Mammalian Phenotype (MP)	increased IgG level	0.3557	Highly Informative	Inherited
Mammalian Phenotype (MP)	abnormal sternum morphology	0.8444	Highly Informative	Inherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)

	WP term	FDR (all)	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	organ system morphology variant	0.01704	Least Informative	Inherited
Worm Phenotype (WP)	cell development variant	0.03895	Least Informative	Inherited
Worm Phenotype (WP)	organism metabolism processing variant	0.05468	Least Informative	Inherited
Worm Phenotype (WP)	cell physiology variant	0.2015	Least Informative	Inherited
Worm Phenotype (WP)	level of transgene expression variant	0.0007574	Moderately Informative	Direct
Worm Phenotype (WP)	cell division variant	0.04409	Moderately Informative	Inherited
Worm Phenotype (WP)	pattern of transgene expression variant	1	Moderately Informative	Inherited
Worm Phenotype (WP)	lineage variant	0.0005078	Highly Informative	Direct
Worm Phenotype (WP)	alimentary system morphology variant	0.0005872	Highly Informative	Direct
Worm Phenotype (WP)	ectopic expression transgene	0.0006075	Highly Informative	Direct
Worm Phenotype (WP)	gene expression level reduced	0.0007301	Highly Informative	Direct

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)

	FP term	FDR (all)	SDFP level	Annotation (direct or inherited)
Fly Phenotype (FP)	cell number defective	0.009122	Informative	Inherited
Fly Phenotype (FP)	cell size defective	0.0222	Highly Informative	Inherited

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)

	FA term	FDR (all)	SDFA level	Annotation (direct or inherited)
Fly Anatomy (FA)	integumentary system	0.00003957	Least Informative	Direct
Fly Anatomy (FA)	adult	0.002437	Least Informative	Inherited
Fly Anatomy (FA)	organ system subdivision	0.00643	Least Informative	Inherited
Fly Anatomy (FA)	anatomical group	0.02505	Least Informative	Inherited
Fly Anatomy (FA)	somatic cell	0.03398	Least Informative	Inherited
Fly Anatomy (FA)	larva	0.1034	Least Informative	Inherited
Fly Anatomy (FA)	embryo	0.2065	Least Informative	Inherited
Fly Anatomy (FA)	anterior-posterior subdivision of organism	1	Least Informative	Inherited
Fly Anatomy (FA)	sense organ	0.01278	Moderately Informative	Inherited
Fly Anatomy (FA)	adult integumentary system	0.0322	Moderately Informative	Inherited
Fly Anatomy (FA)	adult thorax	0.03508	Moderately Informative	Inherited
Fly Anatomy (FA)	late embryo	0.06107	Moderately Informative	Inherited
Fly Anatomy (FA)	thoracic segment	0.1071	Moderately Informative	Inherited
Fly Anatomy (FA)	tagmatic subdivision of integument	0.5368	Moderately Informative	Inherited
Fly Anatomy (FA)	mechanosensory system	0.0002679	Informative	Direct
Fly Anatomy (FA)	circulatory system	0.001722	Informative	Inherited
Fly Anatomy (FA)	anatomical space	0.001939	Informative	Inherited
Fly Anatomy (FA)	head mesoderm derived embryonic hemocyte	0.0001664	Highly Informative	Direct

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)

	ZA term	FDR (all)	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	compound organ	0.6944	Least Informative	Inherited
Zebrafish Anatomy (ZA)	portion of tissue	0.1234	Moderately Informative	Inherited
Zebrafish Anatomy (ZA)	cardiovascular system	0.1721	Moderately Informative	Inherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)

	XA term	FDR (all)	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	tissue	0.1038	Least Informative	Inherited
Xenopus ANatomical entity (XAN)	embryo	0.2129	Least Informative	Inherited
Xenopus ANatomical entity (XAN)	head	0.5646	Least Informative	Inherited
Xenopus ANatomical entity (XAN)	nervous system	0.629	Least Informative	Inherited
Xenopus ANatomical entity (XAN)	cavitated compound organ	0.9307	Least Informative	Inherited
Xenopus ANatomical entity (XAN)	trunk	1	Least Informative	Inherited
Xenopus ANatomical entity (XAN)	multi-tissue structure	0.000002843	Moderately Informative	Direct
Xenopus ANatomical entity (XAN)	sensory system	0.0002188	Moderately Informative	Direct
Xenopus ANatomical entity (XAN)	embryonic structure	0.004059	Moderately Informative	Inherited
Xenopus ANatomical entity (XAN)	musculoskeletal system	0.1541	Moderately Informative	Inherited
Xenopus ANatomical entity (XAN)	viscus	0.737	Moderately Informative	Inherited
Xenopus ANatomical entity (XAN)	ectoderm	0.7704	Moderately Informative	Inherited
Xenopus ANatomical entity (XAN)	brain	0.9756	Moderately Informative	Inherited
Xenopus ANatomical entity (XAN)	mesenchyme	0.000002037	Informative	Direct
Xenopus ANatomical entity (XAN)	pharyngeal region	0.0000128	Informative	Direct
Xenopus ANatomical entity (XAN)	neural plate	0.00001331	Informative	Direct
Xenopus ANatomical entity (XAN)	anatomical direction	0.0000143	Informative	Direct
Xenopus ANatomical entity (XAN)	cardiovascular system	0.00002203	Informative	Direct
Xenopus ANatomical entity (XAN)	cranial placode	0.0001442	Informative	Direct
Xenopus ANatomical entity (XAN)	mesoderm	0.0001724	Informative	Direct
Xenopus ANatomical entity (XAN)	hindbrain	0.0009321	Informative	Direct
Xenopus ANatomical entity (XAN)	forebrain	0.0009784	Informative	Direct
Xenopus ANatomical entity (XAN)	peripheral nervous system	0.002861	Informative	Inherited
Xenopus ANatomical entity (XAN)	surface structure	0.03267	Informative	Inherited
Xenopus ANatomical entity (XAN)	skeletal system	0.115	Informative	Inherited
Xenopus ANatomical entity (XAN)	limb	0.6265	Informative	Inherited
Xenopus ANatomical entity (XAN)	solid compound organ	0.8084	Informative	Inherited
Xenopus ANatomical entity (XAN)	neurogenic placode	0.000004554	Highly Informative	Direct
Xenopus ANatomical entity (XAN)	involuted ventral mesoderm	0.00001334	Highly Informative	Direct
Xenopus ANatomical entity (XAN)	blastema	0.0002531	Highly Informative	Direct
Xenopus ANatomical entity (XAN)	hindlimb	0.000259	Highly Informative	Direct
Xenopus ANatomical entity (XAN)	neuron	0.0005667	Highly Informative	Direct
Xenopus ANatomical entity (XAN)	primordium	0.000735	Highly Informative	Direct
Xenopus ANatomical entity (XAN)	cranium	0.00106	Highly Informative	Inherited
Xenopus ANatomical entity (XAN)	cranial nerve	0.02151	Highly Informative	Inherited
Xenopus ANatomical entity (XAN)	gustatory system	0.02517	Highly Informative	Inherited
Xenopus ANatomical entity (XAN)	branchial arch	0.2311	Highly Informative	Inherited
Xenopus DEvelopment stage (XDE)	post-embryonic stage	0.7547	Least Informative	Inherited
Xenopus DEvelopment stage (XDE)	premetamorphosis stage	0.0003383	Highly Informative	Direct

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)

Highlighted in gray are those with FDR_all>0.001

	KW term	FDR (all)	IC level	SDKW level	Annotation (direct or inherited)
Biological process	Transcription	0	0.8265	--	DIRECT
Biological process	Necrosis	0	2.409	--	DIRECT
Biological process	Lactation	0.00000000000005551	2.329	--	DIRECT
Biological process	Apoptosis	0	1.221	Moderately Informative	DIRECT
Biological process	Transcription regulation	0	0.8848	Moderately Informative	DIRECT
Biological process	Cell cycle	0.00000000001002	1.058	Moderately Informative	DIRECT
Biological process	Differentiation	0.000003567	1.112	Moderately Informative	DIRECT
Biological process	Biological rhythms	0	1.495	Informative	DIRECT
Biological process	Notch signaling pathway	0	1.785	Highly Informative	DIRECT
Cellular component	Nucleus	0	0.709	Least Informative	DIRECT
Cellular component	Endoplasmic reticulum	0.0000000007353	1.022	Moderately Informative	DIRECT
Coding sequence diversity	Alternative promoter usage	0.000272	1.104	Moderately Informative	DIRECT
Disease	Tumor suppressor	0	0.8663	Moderately Informative	DIRECT
Domain	Coiled coil	0.0001218	0.7757	Moderately Informative	DIRECT
Domain	SH2 domain	0	1.537	Informative	DIRECT
Domain	ANK repeat	0.0000001247	1.537	Informative	DIRECT
Molecular function	Zinc	0.0001578	0.5946	Least Informative	DIRECT
Post-translational modification	Activator	0	1.143	Moderately Informative	DIRECT
Post-translational modification	Developmental protein	0	1.023	Moderately Informative	DIRECT
Post-translational modification	DNA-binding	0	0.8349	Moderately Informative	DIRECT
Post-translational modification	Repressor	0	1.124	Moderately Informative	DIRECT
Post-translational modification	Phosphoprotein	0	0.3993	Least Informative	DIRECT
Post-translational modification	Acetylation	0.00000000222	0.7071	Least Informative	DIRECT
Post-translational modification	Ubl conjugation	0	0.7566	Moderately Informative	DIRECT
Post-translational modification	Isopeptide bond	0	0.8684	Moderately Informative	DIRECT
Post-translational modification	Methylation	0.0000007651	1.086	Moderately Informative	DIRECT
Post-translational modification	S-nitrosylation	0.00005412	1.387	Informative	DIRECT
Post-translational modification	ADP-ribosylation	0.00008918	1.563	Informative	DIRECT

	KW term	FDR (all)	SDKW level	Annotation (direct or inherited)
Biological process	Apoptosis	0	Moderately Informative	Direct
Biological process	Transcription regulation	0	Moderately Informative	Direct
Biological process	Cell cycle	0.00000000001002	Moderately Informative	Direct
Biological process	Differentiation	0.000003567	Moderately Informative	Direct
Biological process	Biological rhythms	0	Informative	Direct
Biological process	Notch signaling pathway	0	Highly Informative	Direct
Cellular component	Nucleus	0	Least Informative	Direct
Cellular component	Endoplasmic reticulum	0.0000000007353	Moderately Informative	Direct
Coding sequence diversity	Alternative promoter usage	0.000272	Moderately Informative	Direct
Disease	Tumor suppressor	0	Moderately Informative	Direct
Domain	Coiled coil	0.0001218	Moderately Informative	Direct
Domain	SH2 domain	0	Informative	Direct
Domain	ANK repeat	0.0000001247	Informative	Direct
Molecular function	Zinc	0.0001578	Least Informative	Direct
Post-translational modification	Activator	0	Moderately Informative	Direct
Post-translational modification	Developmental protein	0	Moderately Informative	Direct
Post-translational modification	DNA-binding	0	Moderately Informative	Direct
Post-translational modification	Repressor	0	Moderately Informative	Direct
Post-translational modification	Phosphoprotein	0	Least Informative	Direct
Post-translational modification	Acetylation	0.00000000222	Least Informative	Direct
Post-translational modification	Ubl conjugation	0	Moderately Informative	Direct
Post-translational modification	Isopeptide bond	0	Moderately Informative	Direct
Post-translational modification	Methylation	0.0000007651	Moderately Informative	Direct
Post-translational modification	S-nitrosylation	0.00005412	Informative	Direct
Post-translational modification	ADP-ribosylation	0.00008918	Informative	Direct

Document: KW annotation of SCOP domains

InterPro annotation

Cross references IPR008967 SSF49417 Protein matches

Abstract
This domain is found in a number of transcription factors, including p53, NFATC, TonEBP, STAT-1, and NFkappaB, where it is responsible for DNA-binding. These transcription factors play diverse roles in the regulation of cellular functions: the p53 tumour suppressor upregulates the expression of genes involved in cell cycle arrest and apoptosis [ PubMed 12826037]; NFATC regulates the production of effector proteins involved in coordinating the immune response [ PubMed 8990122]; TonEBP regulates gene expression induced by osmotic stress and helps regulate intracellular volume during cell growth [ PubMed 12729611]; STAT-1 plays an important role in B lymphocyte growth and function [ PubMed 12855573]; and NFkappaB is involved in the inflammatory response [ PubMed 12421671]. The DNA-binding domain acts to clamp, or in the case of TonEBP, encircle the DNA target in order to stabilize the protein-DNA complex [ PubMed 11780147]. Protein interactions may also serve to stabilize the protein-DNA complex, for example in the STAT-1 dimer the SH2 (Src homology 2) domain in each monomer is coupled to the DNA-binding domain to increase stability [ PubMed 9630226]. The DNA-binding domain consists of a beta-sandwich formed of 9 strands in 2 sheets with a Greek-key topology. This structure is found in many transcription factors, often within the DNA-binding domain.

InterPro database

PDBeMotif information about ligands, sequence and structure motifs

Cross references

PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 19 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Browse and view proteins in genomes which have different domain combinations including a p53-like transcription factors domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 19 hidden Markov models representing the p53-like transcription factors superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.

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p53-like transcription factors superfamily