p53-like transcription factors superfamily

SCOP classification

Root:	SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:	All beta proteins [ 48724] (174)
Fold:	Common fold of diphtheria toxin/transcription factors/cytochrome f [ 49379] (10)
Superfamily:	p53-like transcription factors [ 49417] (7)
Families:	p53 DNA-binding domain-like [ 81314] (2)
	Rel/Dorsal transcription factors, DNA-binding domain [ 81315] (6)
	T-box [ 81316] (2)
	STAT DNA-binding domain [ 81317] (3)
	RUNT domain [ 81318]
	DNA-binding domain from NDT80 [ 81992]
	DNA-binding protein LAG-1 (CSL) [ 110080]

Superfamily statistics

	Genomes (367)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	6,320	19,251	53
Proteins	6,210	18,948	53

Functional annotation

General category	Regulation
Detailed category	DNA-binding

Document: Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details)

	DO term	FDR (all)	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	organ system cancer	0.1039	Least Informative	Inherited
Disease Ontology (DO)	hematologic cancer	0.001435	Moderately Informative	Inherited
Disease Ontology (DO)	disease by infectious agent	0.004775	Moderately Informative	Inherited
Disease Ontology (DO)	gastrointestinal system disease	0.0104	Moderately Informative	Inherited
Disease Ontology (DO)	benign neoplasm	0.02447	Moderately Informative	Inherited
Disease Ontology (DO)	head and neck carcinoma	0.000000275	Informative	Direct
Disease Ontology (DO)	inflammatory bowel disease	0.000002621	Informative	Direct
Disease Ontology (DO)	connective tissue cancer	0.00009283	Informative	Direct
Disease Ontology (DO)	physical disorder	0.001184	Informative	Inherited
Disease Ontology (DO)	lymphoma	0.007251	Informative	Inherited
Disease Ontology (DO)	breast cancer	0.008649	Informative	Inherited
Disease Ontology (DO)	cell type benign neoplasm	0.01086	Informative	Inherited
Disease Ontology (DO)	respiratory system cancer	0.1015	Informative	Inherited
Disease Ontology (DO)	viral infectious disease	0.2662	Informative	Inherited
Disease Ontology (DO)	colitis	0.00000008658	Highly Informative	Direct
Disease Ontology (DO)	Burkitt lymphoma	0.00002693	Highly Informative	Direct
Disease Ontology (DO)	mumps	0.00006567	Highly Informative	Direct
Disease Ontology (DO)	Barrett's esophagus	0.00007228	Highly Informative	Direct
Disease Ontology (DO)	gastritis	0.0002481	Highly Informative	Direct
Disease Ontology (DO)	chronic leukemia	0.0003985	Highly Informative	Direct
Disease Ontology (DO)	pertussis	0.0004119	Highly Informative	Direct
Disease Ontology (DO)	progressive multifocal leukoencephalopathy	0.0005132	Highly Informative	Direct
Disease Ontology (DO)	laryngeal carcinoma	0.0005361	Highly Informative	Direct
Disease Ontology (DO)	hemangioma	0.0005535	Highly Informative	Direct
Disease Ontology (DO)	salivary gland adenoid cystic carcinoma	0.0007338	Highly Informative	Direct
Disease Ontology (DO)	large intestine cancer	0.007572	Highly Informative	Inherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)

	HP term	FDR (all)	SDHP level	Annotation (direct or inherited)
Phenotypic Abnormality (PA)	Abnormality of the skeletal system	0.1232	Least Informative	Inherited
Phenotypic Abnormality (PA)	Abnormality of the head	0.2465	Least Informative	Inherited
Phenotypic Abnormality (PA)	Abnormality of limbs	0.365	Least Informative	Inherited
Phenotypic Abnormality (PA)	Abnormality of the upper limb	0.1618	Moderately Informative	Inherited
Phenotypic Abnormality (PA)	Neoplasm	0.1799	Moderately Informative	Inherited
Phenotypic Abnormality (PA)	Abnormality of limb bone	0.1819	Moderately Informative	Inherited
Phenotypic Abnormality (PA)	Abnormality of blood and blood-forming tissues	0.2043	Moderately Informative	Inherited
Phenotypic Abnormality (PA)	Abnormality of the thorax	0.2897	Moderately Informative	Inherited
Phenotypic Abnormality (PA)	Abnormal appendicular skeleton morphology	0.3455	Moderately Informative	Inherited
Phenotypic Abnormality (PA)	Aplasia/hypoplasia of the extremities	0.02653	Informative	Inherited
Phenotypic Abnormality (PA)	Lymphoma	0.0004838	Highly Informative	Direct
Phenotypic Abnormality (PA)	Aplasia/Hypoplasia involving bones of the thorax	0.01183	Highly Informative	Inherited
Phenotypic Abnormality (PA)	Aplasia/hypoplasia involving bones of the hand	0.203	Highly Informative	Inherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)

	MP term	FDR (all)	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	growth/size/body region phenotype	0.00000162	Least Informative	Direct
Mammalian Phenotype (MP)	mortality/aging	0.000002055	Least Informative	Direct
Mammalian Phenotype (MP)	cellular phenotype	0.0002033	Least Informative	Direct
Mammalian Phenotype (MP)	cardiovascular system phenotype	0.0003418	Least Informative	Direct
Mammalian Phenotype (MP)	hematopoietic system phenotype	0.00612	Least Informative	Inherited
Mammalian Phenotype (MP)	immune system phenotype	0.007576	Least Informative	Inherited
Mammalian Phenotype (MP)	nervous system phenotype	0.02697	Least Informative	Inherited
Mammalian Phenotype (MP)	abnormal homeostasis	0.1981	Least Informative	Inherited
Mammalian Phenotype (MP)	abnormal blood cell morphology/development	0.000000009933	Moderately Informative	Direct
Mammalian Phenotype (MP)	abnormal leukocyte physiology	0.0000005021	Moderately Informative	Direct
Mammalian Phenotype (MP)	abnormal skeleton morphology	0.0000008304	Moderately Informative	Direct
Mammalian Phenotype (MP)	integument phenotype	0.000001217	Moderately Informative	Direct
Mammalian Phenotype (MP)	embryo phenotype	0.000001872	Moderately Informative	Direct
Mammalian Phenotype (MP)	respiratory system phenotype	0.000005443	Moderately Informative	Direct
Mammalian Phenotype (MP)	abnormal craniofacial morphology	0.000009455	Moderately Informative	Direct
Mammalian Phenotype (MP)	abnormal gland morphology	0.000009619	Moderately Informative	Direct
Mammalian Phenotype (MP)	abnormal mononuclear cell morphology	0.00002867	Moderately Informative	Direct
Mammalian Phenotype (MP)	limbs/digits/tail phenotype	0.00005785	Moderately Informative	Direct
Mammalian Phenotype (MP)	abnormal blood cell morphology	0.00008696	Moderately Informative	Direct
Mammalian Phenotype (MP)	liver/biliary system phenotype	0.0008506	Moderately Informative	Direct
Mammalian Phenotype (MP)	abnormal inflammatory response	0.001447	Moderately Informative	Inherited
Mammalian Phenotype (MP)	abnormal immune serum protein physiology	0.0036	Moderately Informative	Inherited
Mammalian Phenotype (MP)	abnormal cell death	0.005898	Moderately Informative	Inherited
Mammalian Phenotype (MP)	abnormal cardiovascular system physiology	0.01523	Moderately Informative	Inherited
Mammalian Phenotype (MP)	abnormal immune system organ morphology	0.02007	Moderately Informative	Inherited
Mammalian Phenotype (MP)	abnormal hematopoietic cell number	0.03061	Moderately Informative	Inherited
Mammalian Phenotype (MP)	neoplasm	0.03177	Moderately Informative	Inherited
Mammalian Phenotype (MP)	abnormal blood vessel morphology	0.03401	Moderately Informative	Inherited
Mammalian Phenotype (MP)	abnormal myeloid cell morphology	0.04821	Moderately Informative	Inherited
Mammalian Phenotype (MP)	abnormal heart morphology	0.05446	Moderately Informative	Inherited
Mammalian Phenotype (MP)	lethality during fetal growth through weaning	0.05843	Moderately Informative	Inherited
Mammalian Phenotype (MP)	prenatal lethality	0.083	Moderately Informative	Inherited
Mammalian Phenotype (MP)	abnormal digestive system morphology	0.1005	Moderately Informative	Inherited
Mammalian Phenotype (MP)	abnormal protein level	0.1332	Moderately Informative	Inherited
Mammalian Phenotype (MP)	abnormal professional antigen presenting cell physiology	0.4832	Moderately Informative	Inherited
Mammalian Phenotype (MP)	altered susceptibility to infection	0.5429	Moderately Informative	Inherited
Mammalian Phenotype (MP)	abnormal hormone level	0.7241	Moderately Informative	Inherited
Mammalian Phenotype (MP)	abnormal behavior	1	Moderately Informative	Inherited
Mammalian Phenotype (MP)	abnormal interleukin level	0.00000001077	Informative	Direct
Mammalian Phenotype (MP)	increased susceptibility to infection	0.000000309	Informative	Direct
Mammalian Phenotype (MP)	abnormal liver physiology	0.000003212	Informative	Direct
Mammalian Phenotype (MP)	abnormal thymus morphology	0.0000135	Informative	Direct
Mammalian Phenotype (MP)	abnormal coat appearance	0.00001992	Informative	Direct
Mammalian Phenotype (MP)	abnormal T cell differentiation	0.00003041	Informative	Direct
Mammalian Phenotype (MP)	abnormal fluid regulation	0.0000472	Informative	Direct
Mammalian Phenotype (MP)	normal phenotype	0.0000678	Informative	Direct
Mammalian Phenotype (MP)	abnormal B cell proliferation	0.0001196	Informative	Direct
Mammalian Phenotype (MP)	hemorrhage	0.000136	Informative	Direct
Mammalian Phenotype (MP)	altered tumor pathology	0.0003106	Informative	Direct
Mammalian Phenotype (MP)	increased leukocyte cell number	0.0004407	Informative	Direct
Mammalian Phenotype (MP)	abnormal cartilage morphology	0.002051	Informative	Inherited
Mammalian Phenotype (MP)	abnormal humoral immune response	0.003873	Informative	Inherited
Mammalian Phenotype (MP)	abnormal adaptive thermogenesis	0.004061	Informative	Inherited
Mammalian Phenotype (MP)	abnormal spinal cord morphology	0.008848	Informative	Inherited
Mammalian Phenotype (MP)	abnormal epidermal layer morphology	0.0102	Informative	Inherited
Mammalian Phenotype (MP)	abnormal circulating cytokine level	0.01192	Informative	Inherited
Mammalian Phenotype (MP)	abnormal gland physiology	0.0227	Informative	Inherited
Mammalian Phenotype (MP)	abnormal B lymphocyte antigen presentation	0.02866	Informative	Inherited
Mammalian Phenotype (MP)	abnormal lymph node morphology	0.04134	Informative	Inherited
Mammalian Phenotype (MP)	abnormal head morphology	0.04169	Informative	Inherited
Mammalian Phenotype (MP)	abnormal interferon level	0.07154	Informative	Inherited
Mammalian Phenotype (MP)	abnormal mammary gland morphology	0.07609	Informative	Inherited
Mammalian Phenotype (MP)	abnormal appendicular skeleton morphology	0.08007	Informative	Inherited
Mammalian Phenotype (MP)	abnormal thoracic cage morphology	0.2403	Informative	Inherited
Mammalian Phenotype (MP)	abnormal natural killer cell mediated cytotoxicity	0.2424	Informative	Inherited
Mammalian Phenotype (MP)	abnormal stomach morphology	0.3271	Informative	Inherited
Mammalian Phenotype (MP)	increased hemolymphoid system tumor incidence	0.3509	Informative	Inherited
Mammalian Phenotype (MP)	increased carcinoma incidence	0.3809	Informative	Inherited
Mammalian Phenotype (MP)	abnormal voluntary movement	0.4845	Informative	Inherited
Mammalian Phenotype (MP)	abnormal erythroid lineage cell morphology	0.5392	Informative	Inherited
Mammalian Phenotype (MP)	abnormal vertebrae morphology	0.6966	Informative	Inherited
Mammalian Phenotype (MP)	abnormal Peyer's patch morphology	0.8937	Informative	Inherited
Mammalian Phenotype (MP)	decreased B cell proliferation	0.000006247	Highly Informative	Direct
Mammalian Phenotype (MP)	abnormal mammary gland epithelium physiology	0.000009144	Highly Informative	Direct
Mammalian Phenotype (MP)	respiratory system inflammation	0.000009672	Highly Informative	Direct
Mammalian Phenotype (MP)	lethality throughout fetal growth and development, complete penetrance	0.00002656	Highly Informative	Direct
Mammalian Phenotype (MP)	abnormal secondary palate development	0.00006093	Highly Informative	Direct
Mammalian Phenotype (MP)	abnormal intervertebral disk morphology	0.0001113	Highly Informative	Direct
Mammalian Phenotype (MP)	impaired adaptive thermogenesis	0.0001291	Highly Informative	Direct
Mammalian Phenotype (MP)	decreased dendritic cell number	0.0001311	Highly Informative	Direct
Mammalian Phenotype (MP)	abnormal cervical atlas morphology	0.0001411	Highly Informative	Direct
Mammalian Phenotype (MP)	abnormal stomach epithelium morphology	0.0001707	Highly Informative	Direct
Mammalian Phenotype (MP)	cleft palate	0.0002128	Highly Informative	Direct
Mammalian Phenotype (MP)	abnormal level of surface class II molecules	0.0002749	Highly Informative	Direct
Mammalian Phenotype (MP)	abnormal thymus medulla morphology	0.0003091	Highly Informative	Direct
Mammalian Phenotype (MP)	abnormal heart development	0.0003209	Highly Informative	Direct
Mammalian Phenotype (MP)	abnormal circulating insulin-like growth factor I level	0.0005456	Highly Informative	Direct
Mammalian Phenotype (MP)	increased adenocarcinoma incidence	0.0006227	Highly Informative	Direct
Mammalian Phenotype (MP)	abnormal granulocyte number	0.0006578	Highly Informative	Direct
Mammalian Phenotype (MP)	abnormal vertebral arch morphology	0.0008303	Highly Informative	Direct
Mammalian Phenotype (MP)	abnormal mammary gland alveolus morphology	0.0008645	Highly Informative	Direct
Mammalian Phenotype (MP)	abnormal spinal cord white matter morphology	0.008992	Highly Informative	Inherited
Mammalian Phenotype (MP)	abnormal IgG2a level	0.01024	Highly Informative	Inherited
Mammalian Phenotype (MP)	abnormal head movements	0.01287	Highly Informative	Inherited
Mammalian Phenotype (MP)	increased leukemia incidence	0.01364	Highly Informative	Inherited
Mammalian Phenotype (MP)	abnormal bone marrow cell morphology/development	0.01871	Highly Informative	Inherited
Mammalian Phenotype (MP)	embryonic lethality during organogenesis	0.0602	Highly Informative	Inherited
Mammalian Phenotype (MP)	abnormal Peyer's patch size	0.1245	Highly Informative	Inherited
Mammalian Phenotype (MP)	abnormal peripheral lymph node morphology	0.1484	Highly Informative	Inherited
Mammalian Phenotype (MP)	abnormal epidermis stratum spinosum morphology	0.219	Highly Informative	Inherited
Mammalian Phenotype (MP)	abnormal neurocranium morphology	0.264	Highly Informative	Inherited
Mammalian Phenotype (MP)	increased IgG level	0.3557	Highly Informative	Inherited
Mammalian Phenotype (MP)	abnormal sternum morphology	0.8445	Highly Informative	Inherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)

	WP term	FDR (all)	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	organ system morphology variant	0.01799	Least Informative	Inherited
Worm Phenotype (WP)	cell development variant	0.04318	Least Informative	Inherited
Worm Phenotype (WP)	organism metabolism processing variant	0.05521	Least Informative	Inherited
Worm Phenotype (WP)	cell physiology variant	0.2043	Least Informative	Inherited
Worm Phenotype (WP)	level of transgene expression variant	0.0007807	Moderately Informative	Direct
Worm Phenotype (WP)	cell division variant	0.04358	Moderately Informative	Inherited
Worm Phenotype (WP)	pattern of transgene expression variant	1	Moderately Informative	Inherited
Worm Phenotype (WP)	lineage variant	0.0004764	Highly Informative	Direct
Worm Phenotype (WP)	alimentary system morphology variant	0.0005839	Highly Informative	Direct
Worm Phenotype (WP)	ectopic expression transgene	0.0006114	Highly Informative	Direct
Worm Phenotype (WP)	gene expression level reduced	0.0007356	Highly Informative	Direct

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)

	FP term	FDR (all)	SDFP level	Annotation (direct or inherited)
Fly Phenotype (FP)	cell number defective	0.01601	Informative	Inherited
Fly Phenotype (FP)	increased cell number	0.0004811	Highly Informative	Direct
Fly Phenotype (FP)	cell size defective	0.02211	Highly Informative	Inherited

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)

	FA term	FDR (all)	SDFA level	Annotation (direct or inherited)
Fly Anatomy (FA)	adult	0.002418	Least Informative	Inherited
Fly Anatomy (FA)	organ system subdivision	0.01023	Least Informative	Inherited
Fly Anatomy (FA)	anatomical group	0.02571	Least Informative	Inherited
Fly Anatomy (FA)	somatic cell	0.03732	Least Informative	Inherited
Fly Anatomy (FA)	larva	0.1048	Least Informative	Inherited
Fly Anatomy (FA)	anterior-posterior subdivision of organism	1	Least Informative	Inherited
Fly Anatomy (FA)	sense organ	0.01247	Moderately Informative	Inherited
Fly Anatomy (FA)	adult segment	0.02418	Moderately Informative	Inherited
Fly Anatomy (FA)	adult integumentary system	0.03108	Moderately Informative	Inherited
Fly Anatomy (FA)	adult thorax	0.03399	Moderately Informative	Inherited
Fly Anatomy (FA)	late embryo	0.05987	Moderately Informative	Inherited
Fly Anatomy (FA)	thoracic segment	0.1121	Moderately Informative	Inherited
Fly Anatomy (FA)	tagmatic subdivision of integument	0.54	Moderately Informative	Inherited
Fly Anatomy (FA)	embryonic/larval circulatory system	0.0002345	Informative	Direct
Fly Anatomy (FA)	mechanosensory system	0.0002435	Informative	Direct
Fly Anatomy (FA)	hemocyte	0.01786	Informative	Inherited
Fly Anatomy (FA)	head mesoderm derived embryonic hemocyte	0.0001628	Highly Informative	Direct
Fly Anatomy (FA)	mesothoracic tergum	0.000455	Highly Informative	Direct

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)

	ZA term	FDR (all)	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	compound organ	0.5475	Least Informative	Inherited
Zebrafish Anatomy (ZA)	cardiovascular system	0.03772	Moderately Informative	Inherited
Zebrafish Anatomy (ZA)	portion of tissue	0.06583	Moderately Informative	Inherited
Zebrafish Anatomy (ZA)	anatomical cluster	0.346	Moderately Informative	Inherited
Zebrafish Anatomy (ZA)	pericardial region	0.2249	Informative	Inherited
Zebrafish Anatomy (ZA)	mesenchyme	0.00003683	Highly Informative	Direct

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)

	XA term	FDR (all)	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	tissue	0.1121	Least Informative	Inherited
Xenopus ANatomical entity (XAN)	embryo	0.2256	Least Informative	Inherited
Xenopus ANatomical entity (XAN)	head	0.5641	Least Informative	Inherited
Xenopus ANatomical entity (XAN)	nervous system	0.632	Least Informative	Inherited
Xenopus ANatomical entity (XAN)	cavitated compound organ	0.9307	Least Informative	Inherited
Xenopus ANatomical entity (XAN)	trunk	1	Least Informative	Inherited
Xenopus ANatomical entity (XAN)	multi-tissue structure	0.000001116	Moderately Informative	Direct
Xenopus ANatomical entity (XAN)	sensory system	0.0002555	Moderately Informative	Direct
Xenopus ANatomical entity (XAN)	embryonic structure	0.004406	Moderately Informative	Inherited
Xenopus ANatomical entity (XAN)	musculoskeletal system	0.1579	Moderately Informative	Inherited
Xenopus ANatomical entity (XAN)	viscus	0.7365	Moderately Informative	Inherited
Xenopus ANatomical entity (XAN)	ectoderm	0.7637	Moderately Informative	Inherited
Xenopus ANatomical entity (XAN)	mesenchyme	0.000002416	Informative	Direct
Xenopus ANatomical entity (XAN)	pharyngeal region	0.000004573	Informative	Direct
Xenopus ANatomical entity (XAN)	anatomical direction	0.00001508	Informative	Direct
Xenopus ANatomical entity (XAN)	neural plate	0.00001632	Informative	Direct
Xenopus ANatomical entity (XAN)	cardiovascular system	0.00003269	Informative	Direct
Xenopus ANatomical entity (XAN)	cranial placode	0.0001606	Informative	Direct
Xenopus ANatomical entity (XAN)	peripheral nervous system	0.003023	Informative	Inherited
Xenopus ANatomical entity (XAN)	lateral plate mesoderm	0.01393	Informative	Inherited
Xenopus ANatomical entity (XAN)	surface structure	0.0365	Informative	Inherited
Xenopus ANatomical entity (XAN)	skeletal system	0.1175	Informative	Inherited
Xenopus ANatomical entity (XAN)	limb	0.6254	Informative	Inherited
Xenopus ANatomical entity (XAN)	solid compound organ	0.8093	Informative	Inherited
Xenopus ANatomical entity (XAN)	neurogenic placode	0.000005171	Highly Informative	Direct
Xenopus ANatomical entity (XAN)	blastema	0.0002526	Highly Informative	Direct
Xenopus ANatomical entity (XAN)	hindlimb	0.0002589	Highly Informative	Direct
Xenopus ANatomical entity (XAN)	neuron	0.0006675	Highly Informative	Direct
Xenopus ANatomical entity (XAN)	primordium	0.0007612	Highly Informative	Direct
Xenopus ANatomical entity (XAN)	cranium	0.001179	Highly Informative	Inherited
Xenopus ANatomical entity (XAN)	cranial nerve	0.02385	Highly Informative	Inherited
Xenopus ANatomical entity (XAN)	gustatory system	0.02523	Highly Informative	Inherited
Xenopus ANatomical entity (XAN)	branchial arch	0.2075	Highly Informative	Inherited
Xenopus ANatomical entity (XAN)	marginal zone	1	Highly Informative	Inherited
Xenopus DEvelopment stage (XDE)	post-embryonic stage	0.764	Least Informative	Inherited
Xenopus DEvelopment stage (XDE)	premetamorphosis stage	0.0004077	Highly Informative	Direct

Document: XA annotation of SCOP domains

InterPro annotation

Cross references IPR008967 SSF49417 Protein matches

Abstract
This domain is found in a number of transcription factors, including p53, NFATC, TonEBP, STAT-1, and NFkappaB, where it is responsible for DNA-binding. These transcription factors play diverse roles in the regulation of cellular functions: the p53 tumour suppressor upregulates the expression of genes involved in cell cycle arrest and apoptosis [ PubMed 12826037]; NFATC regulates the production of effector proteins involved in coordinating the immune response [ PubMed 8990122]; TonEBP regulates gene expression induced by osmotic stress and helps regulate intracellular volume during cell growth [ PubMed 12729611]; STAT-1 plays an important role in B lymphocyte growth and function [ PubMed 12855573]; and NFkappaB is involved in the inflammatory response [ PubMed 12421671]. The DNA-binding domain acts to clamp, or in the case of TonEBP, encircle the DNA target in order to stabilize the protein-DNA complex [ PubMed 11780147]. Protein interactions may also serve to stabilize the protein-DNA complex, for example in the STAT-1 dimer the SH2 (Src homology 2) domain in each monomer is coupled to the DNA-binding domain to increase stability [ PubMed 9630226]. The DNA-binding domain consists of a beta-sandwich formed of 9 strands in 2 sheets with a Greek-key topology. This structure is found in many transcription factors, often within the DNA-binding domain.

InterPro database

PDBeMotif information about ligands, sequence and structure motifs

Cross references

PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 26 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Browse and view proteins in genomes which have different domain combinations including a p53-like transcription factors domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 26 hidden Markov models representing the p53-like transcription factors superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.

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p53-like transcription factors superfamily