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p53-like transcription factors superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Common fold of diphtheria toxin/transcription factors/cytochrome f [ 49379] (10)
Superfamily:   p53-like transcription factors [ 49417] (7)
Families:   p53 DNA-binding domain-like [ 81314] (2)
  Rel/Dorsal transcription factors, DNA-binding domain [ 81315] (6)
  T-box [ 81316] (2)
  STAT DNA-binding domain [ 81317] (3)
  RUNT domain [ 81318]
  DNA-binding domain from NDT80 [ 81992]
  DNA-binding protein LAG-1 (CSL) [ 110080]


Superfamily statistics
Genomes (360) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 6,141 7,648 53
Proteins 6,032 7,570 53


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism cellular process0.30150.000375Least InformativeInherited
Biological Process (BP)biological regulation0.01720Least InformativeInherited
Biological Process (BP)regulation of gene expression0.0001050Moderately InformativeDirect
Biological Process (BP)cellular developmental process0.00026450Moderately InformativeDirect
Biological Process (BP)regulation of nitrogen compound metabolic process0.11740Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.0074130Moderately InformativeInherited
Biological Process (BP)regulation of biosynthetic process0.10950Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.022060Moderately InformativeInherited
Biological Process (BP)regulation of cellular metabolic process0.15880Moderately InformativeInherited
Biological Process (BP)system development0.68410.83Moderately InformativeInherited
Biological Process (BP)positive regulation of gene expression0.0000019750InformativeDirect
Biological Process (BP)circulatory system development0.000016140.0000000006416InformativeDirect
Biological Process (BP)behavior0.000016310InformativeDirect
Biological Process (BP)positive regulation of cellular biosynthetic process0.000039240InformativeDirect
Biological Process (BP)positive regulation of nitrogen compound metabolic process0.0080530InformativeInherited
Biological Process (BP)positive regulation of macromolecule biosynthetic process0.005670InformativeInherited
Biological Process (BP)regulation of transcription, DNA-templated0.19210InformativeInherited
Biological Process (BP)regulation of transcription from RNA polymerase II promoter0.0000079340.0000000915Highly InformativeDirect
Molecular Function (MF)binding0.068560Least InformativeInherited
Molecular Function (MF)nucleic acid binding0.00017840Moderately InformativeDirect
Molecular Function (MF)transcription factor activity, sequence-specific DNA binding0.00000000000017560InformativeDirect
Molecular Function (MF)DNA binding0.0000067670InformativeDirect
Molecular Function (MF)sequence-specific DNA binding0.000000018220.0001118Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.000375 Least Informative Direct
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 0.2379 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.03615 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.05114 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.1097 Least Informative Inherited
Biological Process (BP) regulation of gene expression 0 Moderately Informative Direct
Biological Process (BP) cellular developmental process 0 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.00000000001284 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.00000189 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.0000002241 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0 Moderately Informative Direct
Biological Process (BP) regulation of biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of nitrogen compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular metabolic process 0 Moderately Informative Direct
Biological Process (BP) cell communication 0 Moderately Informative Direct
Biological Process (BP) signaling 0 Moderately Informative Direct
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) reproduction 0.0000000878 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.000003056 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.000007414 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.0001607 Moderately Informative Direct
Biological Process (BP) response to stress 0.0004929 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0.00738 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.002929 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.001093 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.5742 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.03577 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.07569 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.008737 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing compound biosynthetic process 0.001151 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.1929 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.01758 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.5526 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) system development 0.83 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.3691 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.2331 Moderately Informative Inherited
Biological Process (BP) gene expression 0.4524 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of gene expression 0 Informative Direct
Biological Process (BP) circulatory system development 0.0000000006416 Informative Direct
Biological Process (BP) behavior 0 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0 Informative Direct
Biological Process (BP) regulation of cell differentiation 0.000000000007556 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0 Informative Direct
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0 Informative Direct
Biological Process (BP) embryo development 0.00000000005151 Informative Direct
Biological Process (BP) regulation of transcription, DNA-templated 0 Informative Direct
Biological Process (BP) regulation of cell proliferation 0 Informative Direct
Biological Process (BP) response to cytokine 0 Informative Direct
Biological Process (BP) cell death 0 Informative Direct
Biological Process (BP) intracellular signal transduction 0.000000000000003692 Informative Direct
Biological Process (BP) regulation of growth 0.00000001512 Informative Direct
Biological Process (BP) transcription, DNA-templated 0.0000001014 Informative Direct
Biological Process (BP) positive regulation of cell death 0.0000002212 Informative Direct
Biological Process (BP) DNA metabolic process 0.000001302 Informative Direct
Biological Process (BP) animal organ morphogenesis 0.000002628 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.000005191 Informative Direct
Biological Process (BP) regulation of hydrolase activity 0.000009371 Informative Direct
Biological Process (BP) cellular response to hormone stimulus 0.000009945 Informative Direct
Biological Process (BP) regulation of organelle organization 0.0000113 Informative Direct
Biological Process (BP) regulation of proteolysis 0.00001814 Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.00003745 Informative Direct
Biological Process (BP) immune response 0.00006211 Informative Direct
Biological Process (BP) locomotion 0.0000741 Informative Direct
Biological Process (BP) response to nitrogen compound 0.00009704 Informative Direct
Biological Process (BP) lipid localization 0.0003691 Informative Direct
Biological Process (BP) secretion 0.0005684 Informative Direct
Biological Process (BP) regulation of locomotion 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.6424 Informative Inherited
Biological Process (BP) negative regulation of transport 0.2881 Informative Inherited
Biological Process (BP) regulation of cellular localization 0.4491 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.7611 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.05944 Informative Inherited
Biological Process (BP) cell adhesion 0.1115 Informative Inherited
Biological Process (BP) cellular response to lipid 0.7966 Informative Inherited
Biological Process (BP) growth 0.156 Informative Inherited
Biological Process (BP) cell development 1 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.4259 Informative Inherited
Biological Process (BP) system process 0.8977 Informative Inherited
Biological Process (BP) regulation of defense response 0.4321 Informative Inherited
Biological Process (BP) central nervous system development 0.5343 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.02686 Informative Inherited
Biological Process (BP) mitochondrion organization 0.5205 Informative Inherited
Biological Process (BP) regulation of secretion 0.002041 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.07091 Informative Inherited
Biological Process (BP) regulation of nervous system development 1 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.2515 Informative Inherited
Biological Process (BP) protein targeting 0.07279 Informative Inherited
Biological Process (BP) response to radiation 0.03974 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.09546 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.1918 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 1 Informative Inherited
Biological Process (BP) response to oxidative stress 0.4023 Informative Inherited
Biological Process (BP) response to inorganic substance 0.9331 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.007425 Informative Inherited
Biological Process (BP) cellular ketone metabolic process 0.05276 Informative Inherited
Biological Process (BP) epithelium development 0.1495 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 0.01233 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) generation of neurons 0.8077 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.6794 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.1052 Informative Inherited
Biological Process (BP) response to acid chemical 0.6991 Informative Inherited
Biological Process (BP) single organism reproductive process 0.1677 Informative Inherited
Biological Process (BP) regulation of cellular component movement 1 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.9652 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.3724 Informative Inherited
Biological Process (BP) cellular response to DNA damage stimulus 0.1661 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) single-organism membrane organization 0.643 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 1 Informative Inherited
Biological Process (BP) nucleocytoplasmic transport 0.01672 Informative Inherited
Biological Process (BP) single-organism intracellular transport 0.3083 Informative Inherited
Biological Process (BP) protein localization to organelle 0.1873 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.001567 Informative Inherited
Biological Process (BP) movement of cell or subcellular component 0.1024 Informative Inherited
Biological Process (BP) reproductive system development 1 Informative Inherited
Biological Process (BP) multicellular organism reproduction 1 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.0000000915 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-templated 0 Highly Informative Direct
Biological Process (BP) lymphocyte activation 0 Highly Informative Direct
Biological Process (BP) cytokine-mediated signaling pathway 0 Highly Informative Direct
Biological Process (BP) apoptotic process 0 Highly Informative Direct
Biological Process (BP) regulation of mitochondrion organization 0 Highly Informative Direct
Biological Process (BP) photoperiodism 0.00000000000001068 Highly Informative Direct
Biological Process (BP) cell proliferation 0.000000000001506 Highly Informative Direct
Biological Process (BP) pattern specification process 0.00000000000198 Highly Informative Direct
Biological Process (BP) positive regulation of organelle organization 0.00000000001036 Highly Informative Direct
Biological Process (BP) response to purine-containing compound 0.00000000001516 Highly Informative Direct
Biological Process (BP) response to nutrient levels 0.00000000001703 Highly Informative Direct
Biological Process (BP) response to organophosphorus 0.0000000001763 Highly Informative Direct
Biological Process (BP) response to peptide hormone 0.0000000002758 Highly Informative Direct
Biological Process (BP) positive regulation of proteolysis 0.000000002038 Highly Informative Direct
Biological Process (BP) regulation of apoptotic signaling pathway 0.000000003008 Highly Informative Direct
Biological Process (BP) aging 0.00000001022 Highly Informative Direct
Biological Process (BP) cell migration 0.00000003466 Highly Informative Direct
Biological Process (BP) regulation of circadian rhythm 0.0000000394 Highly Informative Direct
Biological Process (BP) negative regulation of growth 0.0000001007 Highly Informative Direct
Biological Process (BP) chromosome organization 0.0000004087 Highly Informative Direct
Biological Process (BP) appendage development 0.0000006617 Highly Informative Direct
Biological Process (BP) regulation of smooth muscle cell proliferation 0.0000006914 Highly Informative Direct
Biological Process (BP) response to hydrogen peroxide 0.000001053 Highly Informative Direct
Biological Process (BP) response to retinoic acid 0.000002605 Highly Informative Direct
Biological Process (BP) innate immune response 0.000003045 Highly Informative Direct
Biological Process (BP) positive regulation of lymphocyte activation 0.000003669 Highly Informative Direct
Biological Process (BP) sex differentiation 0.00001541 Highly Informative Direct
Biological Process (BP) leukocyte cell-cell adhesion 0.00005034 Highly Informative Direct
Biological Process (BP) mitochondrial membrane organization 0.00006094 Highly Informative Direct
Biological Process (BP) tube morphogenesis 0.0001098 Highly Informative Direct
Biological Process (BP) angiogenesis 0.00016 Highly Informative Direct
Biological Process (BP) wound healing 0.0001695 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular signal transduction 0.000185 Highly Informative Direct
Biological Process (BP) positive regulation of apoptotic process 0.0001889 Highly Informative Direct
Biological Process (BP) cellular response to organonitrogen compound 0.0002067 Highly Informative Direct
Biological Process (BP) regulation of membrane permeability 0.0002975 Highly Informative Direct
Biological Process (BP) calcium-mediated signaling 0.000424 Highly Informative Direct
Biological Process (BP) multicellular organismal homeostasis 0.0004714 Highly Informative Direct
Biological Process (BP) protein targeting to nucleus 0.0006129 Highly Informative Direct
Biological Process (BP) single-organism nuclear import 0.0006651 Highly Informative Direct
Biological Process (BP) regulation of cell growth 0.0007497 Highly Informative Direct
Biological Process (BP) embryonic organ morphogenesis 0.0008799 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.3832 Highly Informative Inherited
Biological Process (BP) regulation of neurotransmitter levels 0.04108 Highly Informative Inherited
Biological Process (BP) negative regulation of secretion by cell 0.003297 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.04308 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.07338 Highly Informative Inherited
Biological Process (BP) negative regulation of cellular component movement 0.3195 Highly Informative Inherited
Biological Process (BP) regulation of vesicle-mediated transport 0.9639 Highly Informative Inherited
Biological Process (BP) inner ear development 0.008136 Highly Informative Inherited
Biological Process (BP) epithelial cell differentiation 0.4826 Highly Informative Inherited
Biological Process (BP) cellular response to abiotic stimulus 0.1399 Highly Informative Inherited
Biological Process (BP) cellular response to acid chemical 0.4398 Highly Informative Inherited
Biological Process (BP) response to endoplasmic reticulum stress 0.03825 Highly Informative Inherited
Biological Process (BP) response to hypoxia 0.08347 Highly Informative Inherited
Biological Process (BP) regeneration 0.1719 Highly Informative Inherited
Biological Process (BP) gastrulation 0.2726 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.2186 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.2276 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 0.01022 Highly Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 1 Highly Informative Inherited
Biological Process (BP) regulation of inflammatory response 0.004594 Highly Informative Inherited
Biological Process (BP) positive regulation of response to external stimulus 0.2329 Highly Informative Inherited
Biological Process (BP) hemopoiesis 1 Highly Informative Inherited
Biological Process (BP) myeloid cell homeostasis 0.05818 Highly Informative Inherited
Biological Process (BP) sensory organ morphogenesis 0.01971 Highly Informative Inherited
Biological Process (BP) gliogenesis 0.1428 Highly Informative Inherited
Biological Process (BP) circadian rhythm 0.3648 Highly Informative Inherited
Biological Process (BP) mitochondrial transport 0.006681 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.03724 Highly Informative Inherited
Biological Process (BP) negative regulation of cell development 0.9792 Highly Informative Inherited
Biological Process (BP) negative regulation of homeostatic process 0.01984 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.9408 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 0.1756 Highly Informative Inherited
Biological Process (BP) muscle structure development 0.003423 Highly Informative Inherited
Biological Process (BP) cellular hormone metabolic process 0.00326 Highly Informative Inherited
Biological Process (BP) steroid metabolic process 0.02118 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 0.4266 Highly Informative Inherited
Biological Process (BP) regulation of lymphocyte proliferation 0.03238 Highly Informative Inherited
Biological Process (BP) positive regulation of cell adhesion 1 Highly Informative Inherited
Biological Process (BP) hormone-mediated signaling pathway 0.07695 Highly Informative Inherited
Biological Process (BP) neuron development 1 Highly Informative Inherited
Biological Process (BP) positive regulation of leukocyte proliferation 0.7946 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.1308 Highly Informative Inherited
Biological Process (BP) negative regulation of locomotion 0.2814 Highly Informative Inherited
Biological Process (BP) positive regulation of nervous system development 1 Highly Informative Inherited
Biological Process (BP) positive regulation of cell development 1 Highly Informative Inherited
Biological Process (BP) sensory perception 0.4296 Highly Informative Inherited
Biological Process (BP) regulation of cysteine-type endopeptidase activity 0.04124 Highly Informative Inherited
Biological Process (BP) protein import 0.002854 Highly Informative Inherited
Biological Process (BP) regulation of epithelial cell proliferation 0.1205 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.8936 Highly Informative Inherited
Biological Process (BP) ovulation cycle process 0.001863 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) nucleic acid binding 0 Moderately Informative Direct
Molecular Function (MF) metal ion binding 0.0003293 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.3252 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.01128 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 0.7101 Moderately Informative Inherited
Molecular Function (MF) protein binding 1 Moderately Informative Inherited
Molecular Function (MF) transcription factor activity, sequence-specific DNA binding 0 Informative Direct
Molecular Function (MF) DNA binding 0 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.00000003366 Informative Direct
Molecular Function (MF) ribonucleoside binding 0.0000001015 Informative Direct
Molecular Function (MF) purine nucleoside binding 0.0000001063 Informative Direct
Molecular Function (MF) purine nucleotide binding 0.0000003576 Informative Direct
Molecular Function (MF) ribonucleotide binding 0.0000005228 Informative Direct
Molecular Function (MF) protein dimerization activity 0.0000129 Informative Direct
Molecular Function (MF) enzyme binding 0.00004545 Informative Direct
Molecular Function (MF) receptor binding 0.1523 Informative Inherited
Molecular Function (MF) macromolecular complex binding 0.03559 Informative Inherited
Molecular Function (MF) sequence-specific DNA binding 0.0001118 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0 Highly Informative Direct
Molecular Function (MF) copper ion binding 0.0000000000002069 Highly Informative Direct
Molecular Function (MF) ATP binding 0.00000000004802 Highly Informative Direct
Molecular Function (MF) chromatin binding 0.000000241 Highly Informative Direct
Molecular Function (MF) protein phosphatase binding 0.0000003892 Highly Informative Direct
Molecular Function (MF) transcription factor activity, transcription factor binding 0.000002417 Highly Informative Direct
Molecular Function (MF) chaperone binding 0.00005761 Highly Informative Direct
Molecular Function (MF) cytokine receptor binding 0.2294 Highly Informative Inherited
Molecular Function (MF) G-protein coupled receptor binding 0.08423 Highly Informative Inherited
Molecular Function (MF) kinase binding 0.001298 Highly Informative Inherited
Molecular Function (MF) transcription regulatory region DNA binding 1 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.5057 Least Informative Inherited
Cellular Component (CC) protein complex 0.5009 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.0000007015 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.3674 Moderately Informative Inherited
Cellular Component (CC) chromosome 0.000199 Informative Direct
Cellular Component (CC) chromatin 0.0000000000002395 Highly Informative Direct
Cellular Component (CC) nucleolus 0.000000000003399 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.1048Least InformativeInherited
Disease Ontology (DO)hematologic cancer0.001445Moderately InformativeInherited
Disease Ontology (DO)disease by infectious agent0.004408Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.0101Moderately InformativeInherited
Disease Ontology (DO)benign neoplasm0.02377Moderately InformativeInherited
Disease Ontology (DO)head and neck carcinoma0.0000002788InformativeDirect
Disease Ontology (DO)inflammatory bowel disease0.000002264InformativeDirect
Disease Ontology (DO)connective tissue cancer0.00009253InformativeDirect
Disease Ontology (DO)physical disorder0.001195InformativeInherited
Disease Ontology (DO)kidney cancer0.004243InformativeInherited
Disease Ontology (DO)lymphoma0.006797InformativeInherited
Disease Ontology (DO)cell type benign neoplasm0.01038InformativeInherited
Disease Ontology (DO)respiratory system cancer0.1018InformativeInherited
Disease Ontology (DO)viral infectious disease0.2637InformativeInherited
Disease Ontology (DO)breast carcinoma0.3018InformativeInherited
Disease Ontology (DO)colitis0.00000008189Highly InformativeDirect
Disease Ontology (DO)Burkitt lymphoma0.00002445Highly InformativeDirect
Disease Ontology (DO)mumps0.00006864Highly InformativeDirect
Disease Ontology (DO)Barrett's esophagus0.00007015Highly InformativeDirect
Disease Ontology (DO)gastritis0.0002574Highly InformativeDirect
Disease Ontology (DO)pertussis0.0003837Highly InformativeDirect
Disease Ontology (DO)chronic leukemia0.0004169Highly InformativeDirect
Disease Ontology (DO)progressive multifocal leukoencephalopathy0.0004229Highly InformativeDirect
Disease Ontology (DO)laryngeal carcinoma0.0005249Highly InformativeDirect
Disease Ontology (DO)hemangioma0.0005927Highly InformativeDirect
Disease Ontology (DO)salivary gland adenoid cystic carcinoma0.0006872Highly InformativeDirect
Disease Ontology (DO)renal cell carcinoma0.000996Highly InformativeDirect
Disease Ontology (DO)colorectal cancer0.006958Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the immune system0.04968Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.1173Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.3497Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.3793Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the face0.3998Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.4525Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the orbital region0.02544Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the hand0.03847Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal genital system morphology0.07763Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal inflammatory response0.1085Moderately InformativeInherited
Phenotypic Abnormality (PA)Aplasia/hypoplasia involving the skeleton0.1602Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ear0.305Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.772Moderately InformativeInherited
Phenotypic Abnormality (PA)Aplasia/hypoplasia involving bones of the hand0.4311InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eyelid0.963InformativeInherited
Phenotypic Abnormality (PA)Inflammatory abnormality of the eye0.0002459Highly InformativeDirect
Phenotypic Abnormality (PA)Otitis media0.0005761Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the scrotum0.0436Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)growth/size/body region phenotype0.00000184Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0.000003986Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0.0002266Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0.000289Least InformativeDirect
Mammalian Phenotype (MP)immune system phenotype0.003066Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.004536Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.02931Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.1817Least InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.00000002973Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal skeleton morphology0.0000004712Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal leukocyte physiology0.0000007071Moderately InformativeDirect
Mammalian Phenotype (MP)integument phenotype0.000001092Moderately InformativeDirect
Mammalian Phenotype (MP)embryo phenotype0.000002407Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.000006264Moderately InformativeDirect
Mammalian Phenotype (MP)respiratory system phenotype0.000006732Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal gland morphology0.000009606Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal craniofacial morphology0.00001127Moderately InformativeDirect
Mammalian Phenotype (MP)liver/biliary system phenotype0.0009927Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal inflammatory response0.001459Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.003467Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.006078Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.006106Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.02179Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.02774Moderately InformativeInherited
Mammalian Phenotype (MP)neoplasm0.035Moderately InformativeInherited
Mammalian Phenotype (MP)prenatal lethality0.04156Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.04229Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.04428Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.05236Moderately InformativeInherited
Mammalian Phenotype (MP)lethality during fetal growth through weaning0.05851Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.09617Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.09705Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal myeloid cell morphology0.1802Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.4824Moderately InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to infection0.5414Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.6845Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin level0.0000000137InformativeDirect
Mammalian Phenotype (MP)increased susceptibility to infection0.0000003938InformativeDirect
Mammalian Phenotype (MP)abnormal liver physiology0.000003801InformativeDirect
Mammalian Phenotype (MP)abnormal coat appearance0.0000156InformativeDirect
Mammalian Phenotype (MP)abnormal thymus morphology0.00002194InformativeDirect
Mammalian Phenotype (MP)abnormal fluid regulation0.00004287InformativeDirect
Mammalian Phenotype (MP)normal phenotype0.0000901InformativeDirect
Mammalian Phenotype (MP)abnormal B cell proliferation0.0001392InformativeDirect
Mammalian Phenotype (MP)hemorrhage0.0001628InformativeDirect
Mammalian Phenotype (MP)abnormal T cell differentiation0.0001638InformativeDirect
Mammalian Phenotype (MP)altered tumor pathology0.000301InformativeDirect
Mammalian Phenotype (MP)increased hematopoietic cell number0.001558InformativeInherited
Mammalian Phenotype (MP)abnormal cartilage morphology0.00306InformativeInherited
Mammalian Phenotype (MP)abnormal humoral immune response0.003744InformativeInherited
Mammalian Phenotype (MP)abnormal adaptive thermogenesis0.004252InformativeInherited
Mammalian Phenotype (MP)abnormal spinal cord morphology0.008697InformativeInherited
Mammalian Phenotype (MP)abnormal epidermal layer morphology0.01158InformativeInherited
Mammalian Phenotype (MP)abnormal circulating cytokine level0.01901InformativeInherited
Mammalian Phenotype (MP)abnormal bone marrow cell morphology/development0.02153InformativeInherited
Mammalian Phenotype (MP)abnormal gland physiology0.02489InformativeInherited
Mammalian Phenotype (MP)abnormal B lymphocyte antigen presentation0.02856InformativeInherited
Mammalian Phenotype (MP)abnormal interferon level0.07109InformativeInherited
Mammalian Phenotype (MP)abnormal mammary gland morphology0.08653InformativeInherited
Mammalian Phenotype (MP)abnormal lymph node morphology0.08948InformativeInherited
Mammalian Phenotype (MP)abnormal appendicular skeleton morphology0.09956InformativeInherited
Mammalian Phenotype (MP)abnormal natural killer cell mediated cytotoxicity0.2367InformativeInherited
Mammalian Phenotype (MP)abnormal thoracic cage morphology0.2559InformativeInherited
Mammalian Phenotype (MP)abnormal facial morphology0.2725InformativeInherited
Mammalian Phenotype (MP)abnormal stomach morphology0.3InformativeInherited
Mammalian Phenotype (MP)increased hemolymphoid system tumor incidence0.3516InformativeInherited
Mammalian Phenotype (MP)increased carcinoma incidence0.3792InformativeInherited
Mammalian Phenotype (MP)embryonic lethality0.6723InformativeInherited
Mammalian Phenotype (MP)abnormal vertebral column morphology0.7896InformativeInherited
Mammalian Phenotype (MP)abnormal Peyer's patch morphology0.8936InformativeInherited
Mammalian Phenotype (MP)decreased B cell proliferation0.000007509Highly InformativeDirect
Mammalian Phenotype (MP)respiratory system inflammation0.000009448Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mammary gland epithelium physiology0.000009791Highly InformativeDirect
Mammalian Phenotype (MP)lethality throughout fetal growth and development, complete penetrance0.00003118Highly InformativeDirect
Mammalian Phenotype (MP)abnormal secondary palate development0.00006728Highly InformativeDirect
Mammalian Phenotype (MP)abnormal intervertebral disk morphology0.0001336Highly InformativeDirect
Mammalian Phenotype (MP)impaired adaptive thermogenesis0.0001384Highly InformativeDirect
Mammalian Phenotype (MP)decreased dendritic cell number0.0001435Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cervical atlas morphology0.000167Highly InformativeDirect
Mammalian Phenotype (MP)abnormal stomach epithelium morphology0.0001837Highly InformativeDirect
Mammalian Phenotype (MP)cleft palate0.0002414Highly InformativeDirect
Mammalian Phenotype (MP)abnormal level of surface class II molecules0.0002912Highly InformativeDirect
Mammalian Phenotype (MP)abnormal thymus medulla morphology0.0003307Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating insulin-like growth factor I level0.0005475Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart development0.0005582Highly InformativeDirect
Mammalian Phenotype (MP)increased adenocarcinoma incidence0.0006842Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mammary gland alveolus morphology0.0008308Highly InformativeDirect
Mammalian Phenotype (MP)abnormal spinal cord white matter morphology0.009256Highly InformativeInherited
Mammalian Phenotype (MP)abnormal IgG2a level0.01089Highly InformativeInherited
Mammalian Phenotype (MP)increased leukemia incidence0.01354Highly InformativeInherited
Mammalian Phenotype (MP)embryonic lethality during organogenesis0.1132Highly InformativeInherited
Mammalian Phenotype (MP)abnormal Peyer's patch size0.1234Highly InformativeInherited
Mammalian Phenotype (MP)abnormal peripheral lymph node morphology0.1248Highly InformativeInherited
Mammalian Phenotype (MP)abnormal epidermis stratum spinosum morphology0.2106Highly InformativeInherited
Mammalian Phenotype (MP)abnormal neurocranium morphology0.2767Highly InformativeInherited
Mammalian Phenotype (MP)increased IgG level0.3486Highly InformativeInherited
Mammalian Phenotype (MP)abnormal sternum morphology0.853Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organ system morphology variant0.0112Least InformativeInherited
Worm Phenotype (WP)cell development variant0.03721Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.08286Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.4549Least InformativeInherited
Worm Phenotype (WP)level of transgene expression variant0.00004348Moderately InformativeDirect
Worm Phenotype (WP)cell division variant0.06593Moderately InformativeInherited
Worm Phenotype (WP)alimentary system morphology variant0.0002842Highly InformativeDirect
Worm Phenotype (WP)gene expression level reduced0.0003554Highly InformativeDirect
Worm Phenotype (WP)lineage variant0.0004105Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)integumentary system0.00004011Least InformativeDirect
Fly Anatomy (FA)adult0.002044Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.004793Least InformativeInherited
Fly Anatomy (FA)anatomical group0.02531Least InformativeInherited
Fly Anatomy (FA)cell0.06777Least InformativeInherited
Fly Anatomy (FA)larva0.09749Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)sense organ0.0139Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.04261Moderately InformativeInherited
Fly Anatomy (FA)adult thorax0.04579Moderately InformativeInherited
Fly Anatomy (FA)thoracic segment0.1244Moderately InformativeInherited
Fly Anatomy (FA)late embryo0.2368Moderately InformativeInherited
Fly Anatomy (FA)tagmatic subdivision of integument0.6423Moderately InformativeInherited
Fly Anatomy (FA)embryonic/larval circulatory system0.0002467InformativeDirect
Fly Anatomy (FA)mechanosensory system0.0003299InformativeDirect
Fly Anatomy (FA)head mesoderm derived embryonic hemocyte0.0001672Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)organism subdivision0.06687Least InformativeInherited
Zebrafish Anatomy (ZA)compound organ0.5893Least InformativeInherited
Zebrafish Anatomy (ZA)multi-tissue structure0.6701Least InformativeInherited
Zebrafish Anatomy (ZA)cardiovascular system0.08118Moderately InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.1655Moderately InformativeInherited
Zebrafish Anatomy (ZA)trunk0.251Moderately InformativeInherited
Zebrafish Anatomy (ZA)coelom0.223InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.2432Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.2607Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical cluster0.6097Least InformativeInherited
Xenopus ANatomical entity (XAN)nervous system0.6157Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.8762Least InformativeInherited
Xenopus ANatomical entity (XAN)cell1Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.000638Moderately InformativeDirect
Xenopus ANatomical entity (XAN)embryonic structure0.005506Moderately InformativeInherited
Xenopus ANatomical entity (XAN)sensory system0.0812Moderately InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.2233Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.3685Moderately InformativeInherited
Xenopus ANatomical entity (XAN)circulatory system0.000000003064InformativeDirect
Xenopus ANatomical entity (XAN)anatomical direction0.000006211InformativeDirect
Xenopus ANatomical entity (XAN)neural plate0.0000222InformativeDirect
Xenopus ANatomical entity (XAN)pharyngeal region0.0001186InformativeDirect
Xenopus ANatomical entity (XAN)vestibuloauditory system0.000194InformativeDirect
Xenopus ANatomical entity (XAN)notochord0.0003024InformativeDirect
Xenopus ANatomical entity (XAN)peripheral nervous system0.0376InformativeInherited
Xenopus ANatomical entity (XAN)skeletal system0.2426InformativeInherited
Xenopus ANatomical entity (XAN)heart0.3633InformativeInherited
Xenopus ANatomical entity (XAN)limb0.5994InformativeInherited
Xenopus ANatomical entity (XAN)connective tissue0.8146InformativeInherited
Xenopus ANatomical entity (XAN)solid compound organ0.9496InformativeInherited
Xenopus ANatomical entity (XAN)blood vessel0.00000003455Highly InformativeDirect
Xenopus ANatomical entity (XAN)neurogenic placode0.000001779Highly InformativeDirect
Xenopus ANatomical entity (XAN)mesenchyme0.000002869Highly InformativeDirect
Xenopus ANatomical entity (XAN)involuted ventral mesoderm0.000004891Highly InformativeDirect
Xenopus ANatomical entity (XAN)limb bud0.00004394Highly InformativeDirect
Xenopus ANatomical entity (XAN)otic vesicle0.0002024Highly InformativeDirect
Xenopus ANatomical entity (XAN)hindlimb0.0002176Highly InformativeDirect
Xenopus ANatomical entity (XAN)primordium0.0002246Highly InformativeDirect
Xenopus ANatomical entity (XAN)cranium0.0005126Highly InformativeDirect
Xenopus ANatomical entity (XAN)gustatory system0.003488Highly InformativeInherited
Xenopus ANatomical entity (XAN)cranial nerve0.01389Highly InformativeInherited
Xenopus ANatomical entity (XAN)marginal zone1Highly InformativeInherited
Xenopus DEvelopment stage (XDE)NF stage0.0002217Least InformativeDirect
Xenopus DEvelopment stage (XDE)embryonic stage0.000793Least InformativeDirect

Document: XA annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)blood and blood forming organs0.002108Least InformativeInherited
Drugbank ATC_code (DB)nervous system0.01783Least InformativeInherited
Drugbank ATC_code (DB)alimentary tract and metabolism0.05843Least InformativeInherited
Drugbank ATC_code (DB)stomatological preparations0.0001273Moderately InformativeDirect
Drugbank ATC_code (DB)analgesics0.0001943Moderately InformativeDirect
Drugbank ATC_code (DB)antithrombotic agents1Moderately InformativeInherited
Drugbank ATC_code (DB)acetylsalicylic acid0.0000008091InformativeDirect
Drugbank ATC_code (DB)salicylic acid and derivatives0.0000008091InformativeDirect
Drugbank ATC_code (DB)other agents for local oral treatment0.00001009InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis0Moderately InformativeDirect
Biological processTranscription regulation0Moderately InformativeDirect
Biological processCell cycle0.000000000003919Moderately InformativeDirect
Biological processBiological rhythms0InformativeDirect
Biological processNotch signaling pathway0Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentEndoplasmic reticulum0.000000006754Moderately InformativeDirect
Coding sequence diversityAlternative promoter usage0.0001964Moderately InformativeDirect
DiseaseTumor suppressor0Moderately InformativeDirect
DomainCoiled coil0.00007683Moderately InformativeDirect
DomainSH2 domain0InformativeDirect
DomainANK repeat0.0000001004InformativeDirect
Molecular functionDNA-binding0Least InformativeDirect
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationRepressor0Moderately InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationAcetylation0.00000001289Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationIsopeptide bond0Moderately InformativeDirect
Post-translational modificationMethylation0.000008272Moderately InformativeDirect
Post-translational modificationS-nitrosylation0.00003039InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR008967 SSF49417 Protein matches
Abstract

This domain is found in a number of transcription factors, including p53, NFATC, TonEBP, STAT-1, and NFkappaB, where it is responsible for DNA-binding. These transcription factors play diverse roles in the regulation of cellular functions: the p53 tumour suppressor upregulates the expression of genes involved in cell cycle arrest and apoptosis [PubMed12826037]; NFATC regulates the production of effector proteins involved in coordinating the immune response [PubMed8990122]; TonEBP regulates gene expression induced by osmotic stress and helps regulate intracellular volume during cell growth [PubMed12729611]; STAT-1 plays an important role in B lymphocyte growth and function [PubMed12855573]; and NFkappaB is involved in the inflammatory response [PubMed12421671]. The DNA-binding domain acts to clamp, or in the case of TonEBP, encircle the DNA target in order to stabilize the protein-DNA complex [PubMed11780147]. Protein interactions may also serve to stabilize the protein-DNA complex, for example in the STAT-1 dimer the SH2 (Src homology 2) domain in each monomer is coupled to the DNA-binding domain to increase stability [PubMed9630226]. The DNA-binding domain consists of a beta-sandwich formed of 9 strands in 2 sheets with a Greek-key topology. This structure is found in many transcription factors, often within the DNA-binding domain.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 19 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a p53-like transcription factors domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 19 hidden Markov models representing the p53-like transcription factors superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · Internal database links ]