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p53-like transcription factors superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Common fold of diphtheria toxin/transcription factors/cytochrome f [ 49379] (10)
Superfamily:   p53-like transcription factors [ 49417] (7)
Families:   p53 DNA-binding domain-like [ 81314] (2)
  Rel/Dorsal transcription factors, DNA-binding domain [ 81315] (6)
  T-box [ 81316] (2)
  STAT DNA-binding domain [ 81317] (3)
  RUNT domain [ 81318]
  DNA-binding domain from NDT80 [ 81992]
  DNA-binding protein LAG-1 (CSL) [ 110080]


Superfamily statistics
Genomes (367) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 6,320 15,624 53
Proteins 6,210 15,360 53


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process0.00017210Least InformativeDirect
Biological Process (BP)single-organism cellular process0.069550.001623Least InformativeInherited
Biological Process (BP)biological regulation0.01850Least InformativeInherited
Biological Process (BP)regulation of gene expression0.00020430Moderately InformativeDirect
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.00085940Moderately InformativeDirect
Biological Process (BP)regulation of macromolecule biosynthetic process0.075270Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.0075870Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.021660Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process0.0012880Moderately InformativeInherited
Biological Process (BP)positive regulation of gene expression0.0000023620InformativeDirect
Biological Process (BP)regulation of transcription from RNA polymerase II promoter0.000011010.00000003231InformativeDirect
Biological Process (BP)behavior0.000015350.000000000000005563InformativeDirect
Biological Process (BP)circulatory system development0.000019580.0000000003189InformativeDirect
Biological Process (BP)positive regulation of nucleobase-containing compound metabolic process0.000025050InformativeDirect
Biological Process (BP)positive regulation of cellular biosynthetic process0.000044640InformativeDirect
Biological Process (BP)positive regulation of macromolecule biosynthetic process0.0053960InformativeInherited
Molecular Function (MF)binding0.091210Least InformativeInherited
Molecular Function (MF)nucleic acid binding0.00028810Moderately InformativeDirect
Molecular Function (MF)transcription factor activity, sequence-specific DNA binding0.0000000000020810InformativeDirect
Molecular Function (MF)DNA binding0.000015840InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.05669 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.1206 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.04468 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.001623 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 0.2612 Least Informative Inherited
Biological Process (BP) regulation of gene expression 0 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.0000000000004641 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.000003158 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.00000001828 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) animal organ development 0.000000894 Moderately Informative Direct
Biological Process (BP) cell communication 0 Moderately Informative Direct
Biological Process (BP) single organism signaling 0 Moderately Informative Direct
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) tissue development 0.0000000000007615 Moderately Informative Direct
Biological Process (BP) reproduction 0.0000002296 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.0000004298 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.000004859 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.0006078 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0.0008244 Moderately Informative Direct
Biological Process (BP) regulation of signaling 0.004721 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.9861 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.006527 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.6758 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.08125 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.1693 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.01068 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.003161 Moderately Informative Inherited
Biological Process (BP) defense response 0.04942 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.03759 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.003724 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.0248 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.004822 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.08156 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.6715 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.6727 Moderately Informative Inherited
Biological Process (BP) nitrogen compound transport 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.01581 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.2085 Moderately Informative Inherited
Biological Process (BP) gene expression 0.4367 Moderately Informative Inherited
Biological Process (BP) positive regulation of gene expression 0 Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.00000003231 Informative Direct
Biological Process (BP) behavior 0.000000000000005563 Informative Direct
Biological Process (BP) circulatory system development 0.0000000003189 Informative Direct
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 0 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0 Informative Direct
Biological Process (BP) regulation of cell differentiation 0.0000000000001094 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0 Informative Direct
Biological Process (BP) embryo development 0.00000000008112 Informative Direct
Biological Process (BP) regulation of cell proliferation 0 Informative Direct
Biological Process (BP) cell death 0 Informative Direct
Biological Process (BP) intracellular signal transduction 0.000000000000003734 Informative Direct
Biological Process (BP) cell activation 0.000000009874 Informative Direct
Biological Process (BP) transcription, DNA-templated 0.00000003753 Informative Direct
Biological Process (BP) regulation of growth 0.0000000632 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.0000001537 Informative Direct
Biological Process (BP) DNA metabolic process 0.0000005823 Informative Direct
Biological Process (BP) localization of cell 0.000001038 Informative Direct
Biological Process (BP) immune response 0.000003971 Informative Direct
Biological Process (BP) regulation of proteolysis 0.00001063 Informative Direct
Biological Process (BP) regulation of hydrolase activity 0.00001515 Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.00008492 Informative Direct
Biological Process (BP) animal organ morphogenesis 0.00009788 Informative Direct
Biological Process (BP) response to nitrogen compound 0.0001666 Informative Direct
Biological Process (BP) locomotion 0.0002867 Informative Direct
Biological Process (BP) lipid localization 0.0005535 Informative Direct
Biological Process (BP) positive regulation of cellular protein metabolic process 1 Informative Inherited
Biological Process (BP) regulation of cellular localization 0.4857 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.241 Informative Inherited
Biological Process (BP) single-organism cellular localization 0.5538 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.0436 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.6661 Informative Inherited
Biological Process (BP) regulation of peptide transport 0.637 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.05791 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.02198 Informative Inherited
Biological Process (BP) cell development 1 Informative Inherited
Biological Process (BP) cellular response to lipid 0.7342 Informative Inherited
Biological Process (BP) response to wounding 0.9334 Informative Inherited
Biological Process (BP) cellular response to hormone stimulus 0.002653 Informative Inherited
Biological Process (BP) regulation of secretion 0.00138 Informative Inherited
Biological Process (BP) regulation of defense response 0.07148 Informative Inherited
Biological Process (BP) intracellular transport 0.8416 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 1 Informative Inherited
Biological Process (BP) negative regulation of transport 0.2053 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.03187 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.001448 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.6805 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.3383 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.1211 Informative Inherited
Biological Process (BP) cellular response to DNA damage stimulus 0.1822 Informative Inherited
Biological Process (BP) response to oxidative stress 0.4118 Informative Inherited
Biological Process (BP) cellular ketone metabolic process 0.05515 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 0.03548 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) epithelium development 0.359 Informative Inherited
Biological Process (BP) single organism reproductive process 0.1636 Informative Inherited
Biological Process (BP) response to acid chemical 0.5776 Informative Inherited
Biological Process (BP) chromosome organization 0.002089 Informative Inherited
Biological Process (BP) response to extracellular stimulus 0.002513 Informative Inherited
Biological Process (BP) reproductive system development 1 Informative Inherited
Biological Process (BP) central nervous system development 0.3312 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 1 Informative Inherited
Biological Process (BP) regulation of catabolic process 1 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.1957 Informative Inherited
Biological Process (BP) regulation of nervous system development 1 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.01229 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) response to radiation 0.0439 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.02099 Informative Inherited
Biological Process (BP) cell cycle process 1 Informative Inherited
Biological Process (BP) mitochondrion organization 0.06558 Informative Inherited
Biological Process (BP) single-organism membrane organization 0.4946 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.04713 Informative Inherited
Biological Process (BP) protein localization to organelle 0.2228 Informative Inherited
Biological Process (BP) protein transport 0.5755 Informative Inherited
Biological Process (BP) growth 0.007403 Informative Inherited
Biological Process (BP) system process 0.4814 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 1 Informative Inherited
Biological Process (BP) hemopoiesis 1 Informative Inherited
Biological Process (BP) immune effector process 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.005399 Informative Inherited
Biological Process (BP) movement of cell or subcellular component 0.1857 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) multicellular organism reproduction 1 Informative Inherited
Biological Process (BP) heart development 0 Highly Informative Direct
Biological Process (BP) cytokine-mediated signaling pathway 0 Highly Informative Direct
Biological Process (BP) regulation of mitochondrion organization 0 Highly Informative Direct
Biological Process (BP) apoptotic process 0 Highly Informative Direct
Biological Process (BP) photoperiodism 0.00000000000001254 Highly Informative Direct
Biological Process (BP) response to peptide hormone 0.00000000000001254 Highly Informative Direct
Biological Process (BP) cell proliferation 0.00000000000003101 Highly Informative Direct
Biological Process (BP) response to purine-containing compound 0.000000000001342 Highly Informative Direct
Biological Process (BP) response to nutrient levels 0.000000000002314 Highly Informative Direct
Biological Process (BP) embryonic organ development 0.000000000006968 Highly Informative Direct
Biological Process (BP) response to organophosphorus 0.000000000008961 Highly Informative Direct
Biological Process (BP) positive regulation of proteolysis 0.00000000007321 Highly Informative Direct
Biological Process (BP) positive regulation of organelle organization 0.0000000003131 Highly Informative Direct
Biological Process (BP) regulation of apoptotic signaling pathway 0.000000002625 Highly Informative Direct
Biological Process (BP) aging 0.000000009948 Highly Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0.00000002771 Highly Informative Direct
Biological Process (BP) regulation of smooth muscle cell proliferation 0.00000005938 Highly Informative Direct
Biological Process (BP) regulation of circadian rhythm 0.00000007786 Highly Informative Direct
Biological Process (BP) response to hydrogen peroxide 0.00000008592 Highly Informative Direct
Biological Process (BP) negative regulation of growth 0.0000001126 Highly Informative Direct
Biological Process (BP) leukocyte differentiation 0.0000001832 Highly Informative Direct
Biological Process (BP) lymphocyte activation 0.0000004696 Highly Informative Direct
Biological Process (BP) innate immune response 0.0000007186 Highly Informative Direct
Biological Process (BP) regulation of hemopoiesis 0.000001463 Highly Informative Direct
Biological Process (BP) kidney development 0.00000218 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular signal transduction 0.000009574 Highly Informative Direct
Biological Process (BP) positive regulation of apoptotic process 0.00002179 Highly Informative Direct
Biological Process (BP) sex differentiation 0.00002953 Highly Informative Direct
Biological Process (BP) wound healing 0.00003166 Highly Informative Direct
Biological Process (BP) cellular response to organonitrogen compound 0.00003579 Highly Informative Direct
Biological Process (BP) positive regulation of transcription from RNA polymerase II promoter 0.00005635 Highly Informative Direct
Biological Process (BP) response to retinoic acid 0.00005865 Highly Informative Direct
Biological Process (BP) angiogenesis 0.0001028 Highly Informative Direct
Biological Process (BP) mitochondrial membrane organization 0.000103 Highly Informative Direct
Biological Process (BP) appendage development 0.0001055 Highly Informative Direct
Biological Process (BP) maintenance of location 0.0002969 Highly Informative Direct
Biological Process (BP) multicellular organismal homeostasis 0.0003431 Highly Informative Direct
Biological Process (BP) regulation of membrane permeability 0.0006452 Highly Informative Direct
Biological Process (BP) single-organism nuclear import 0.0006926 Highly Informative Direct
Biological Process (BP) carbohydrate homeostasis 0.0008388 Highly Informative Direct
Biological Process (BP) regulation of neurotransmitter levels 0.07594 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.03632 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.06282 Highly Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter in response to stress 0.06325 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular transport 0.002266 Highly Informative Inherited
Biological Process (BP) regulation of vesicle-mediated transport 0.9969 Highly Informative Inherited
Biological Process (BP) second-messenger-mediated signaling 1 Highly Informative Inherited
Biological Process (BP) regulation of hormone secretion 0.3984 Highly Informative Inherited
Biological Process (BP) epithelial cell differentiation 0.4336 Highly Informative Inherited
Biological Process (BP) cellular response to abiotic stimulus 0.1135 Highly Informative Inherited
Biological Process (BP) cellular response to acid chemical 0.1962 Highly Informative Inherited
Biological Process (BP) response to endoplasmic reticulum stress 0.009727 Highly Informative Inherited
Biological Process (BP) myeloid cell differentiation 0.0168 Highly Informative Inherited
Biological Process (BP) cellular response to decreased oxygen levels 0.02434 Highly Informative Inherited
Biological Process (BP) response to hypoxia 0.147 Highly Informative Inherited
Biological Process (BP) regeneration 0.1307 Highly Informative Inherited
Biological Process (BP) anatomical structure homeostasis 0.6885 Highly Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 1 Highly Informative Inherited
Biological Process (BP) neuron development 1 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.2687 Highly Informative Inherited
Biological Process (BP) positive regulation of response to external stimulus 0.288 Highly Informative Inherited
Biological Process (BP) myeloid cell homeostasis 0.09299 Highly Informative Inherited
Biological Process (BP) tube morphogenesis 0.002855 Highly Informative Inherited
Biological Process (BP) gliogenesis 0.2588 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.543 Highly Informative Inherited
Biological Process (BP) circadian rhythm 0.3682 Highly Informative Inherited
Biological Process (BP) negative regulation of secretion by cell 0.001821 Highly Informative Inherited
Biological Process (BP) mitochondrial transport 0.00556 Highly Informative Inherited
Biological Process (BP) negative regulation of nervous system development 0.9481 Highly Informative Inherited
Biological Process (BP) negative regulation of cell development 1 Highly Informative Inherited
Biological Process (BP) positive regulation of homeostatic process 0.01076 Highly Informative Inherited
Biological Process (BP) negative regulation of homeostatic process 0.02434 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.8527 Highly Informative Inherited
Biological Process (BP) positive regulation of lymphocyte activation 0.02166 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.2597 Highly Informative Inherited
Biological Process (BP) sensory organ morphogenesis 0.006651 Highly Informative Inherited
Biological Process (BP) regulation of lymphocyte proliferation 0.07878 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 0.1318 Highly Informative Inherited
Biological Process (BP) positive regulation of leukocyte proliferation 0.8431 Highly Informative Inherited
Biological Process (BP) positive regulation of cell adhesion 1 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.08215 Highly Informative Inherited
Biological Process (BP) programmed cell death involved in cell development 0.1512 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.01863 Highly Informative Inherited
Biological Process (BP) regulation of cell growth 0.003553 Highly Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 0.3916 Highly Informative Inherited
Biological Process (BP) regulation of autophagy 0.009827 Highly Informative Inherited
Biological Process (BP) positive regulation of nervous system development 1 Highly Informative Inherited
Biological Process (BP) positive regulation of cell development 1 Highly Informative Inherited
Biological Process (BP) cellular hormone metabolic process 0.003859 Highly Informative Inherited
Biological Process (BP) nervous system process 1 Highly Informative Inherited
Biological Process (BP) DNA recombination 0.7497 Highly Informative Inherited
Biological Process (BP) nuclear division 0.0422 Highly Informative Inherited
Biological Process (BP) meiotic cell cycle 0.1219 Highly Informative Inherited
Biological Process (BP) regulation of cysteine-type endopeptidase activity 0.02544 Highly Informative Inherited
Biological Process (BP) protein localization to nucleus 0.002197 Highly Informative Inherited
Biological Process (BP) protein import 0.00305 Highly Informative Inherited
Biological Process (BP) developmental growth involved in morphogenesis 0.6585 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.8097 Highly Informative Inherited
Biological Process (BP) regulation of humoral immune response 0.02961 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 0.01367 Highly Informative Inherited
Biological Process (BP) regulation of epithelial cell proliferation 0.07887 Highly Informative Inherited
Biological Process (BP) gastrulation 0.2102 Highly Informative Inherited
Biological Process (BP) ovulation cycle process 0.0022 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) nucleic acid binding 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.02406 Moderately Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 0.2197 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 0.8057 Moderately Informative Inherited
Molecular Function (MF) metal ion binding 0.001031 Moderately Informative Inherited
Molecular Function (MF) transcription factor activity, sequence-specific DNA binding 0 Informative Direct
Molecular Function (MF) DNA binding 0 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.0000000721 Informative Direct
Molecular Function (MF) purine nucleotide binding 0.0000007917 Informative Direct
Molecular Function (MF) ribonucleotide binding 0.000001172 Informative Direct
Molecular Function (MF) enzyme binding 0.000002185 Informative Direct
Molecular Function (MF) protein dimerization activity 0.00004221 Informative Direct
Molecular Function (MF) receptor binding 0.08112 Informative Inherited
Molecular Function (MF) transcription factor binding 0 Highly Informative Direct
Molecular Function (MF) copper ion binding 0.00000000000005664 Highly Informative Direct
Molecular Function (MF) ATP binding 0.000000000115 Highly Informative Direct
Molecular Function (MF) protein phosphatase binding 0.0000004858 Highly Informative Direct
Molecular Function (MF) chromatin binding 0.000002194 Highly Informative Direct
Molecular Function (MF) chaperone binding 0.0004507 Highly Informative Direct
Molecular Function (MF) kinase binding 0.0005576 Highly Informative Direct
Molecular Function (MF) cytokine receptor binding 0.1281 Highly Informative Inherited
Molecular Function (MF) G-protein coupled receptor binding 0.03554 Highly Informative Inherited
Molecular Function (MF) transcription factor activity, transcription factor binding 0.3801 Highly Informative Inherited
Molecular Function (MF) double-stranded DNA binding 0.0409 Highly Informative Inherited
Molecular Function (MF) transcription regulatory region DNA binding 1 Highly Informative Inherited
Molecular Function (MF) sequence-specific DNA binding 0.006655 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) protein complex 0.0302 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.803 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.0000002473 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.2507 Moderately Informative Inherited
Cellular Component (CC) chromosome 0.0002029 Informative Direct
Cellular Component (CC) protein-DNA complex 0.0006552 Informative Direct
Cellular Component (CC) chromatin 0.0000009476 Highly Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis0Moderately InformativeDirect
Biological processTranscription regulation0Moderately InformativeDirect
Biological processCell cycle0.000000000004994Moderately InformativeDirect
Biological processDifferentiation0.000298Moderately InformativeDirect
Biological processBiological rhythms0InformativeDirect
Biological processNotch signaling pathway0Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentEndoplasmic reticulum0.0000000004635Moderately InformativeDirect
Coding sequence diversityAlternative promoter usage0.0002359Moderately InformativeDirect
DiseaseTumor suppressor0Moderately InformativeDirect
DomainCoiled coil0.0001108Moderately InformativeDirect
DomainSH2 domain0InformativeDirect
DomainANK repeat0.0000001251InformativeDirect
Molecular functionZinc0.0001237Least InformativeDirect
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationDNA-binding0Moderately InformativeDirect
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationRepressor0Moderately InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationAcetylation0.00000002004Least InformativeDirect
Post-translational modificationIsopeptide bond0Moderately InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationMethylation0.00001127Moderately InformativeDirect
Post-translational modificationS-nitrosylation0.00004028InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR008967 SSF49417 Protein matches
Abstract

This domain is found in a number of transcription factors, including p53, NFATC, TonEBP, STAT-1, and NFkappaB, where it is responsible for DNA-binding. These transcription factors play diverse roles in the regulation of cellular functions: the p53 tumour suppressor upregulates the expression of genes involved in cell cycle arrest and apoptosis [PubMed12826037]; NFATC regulates the production of effector proteins involved in coordinating the immune response [PubMed8990122]; TonEBP regulates gene expression induced by osmotic stress and helps regulate intracellular volume during cell growth [PubMed12729611]; STAT-1 plays an important role in B lymphocyte growth and function [PubMed12855573]; and NFkappaB is involved in the inflammatory response [PubMed12421671]. The DNA-binding domain acts to clamp, or in the case of TonEBP, encircle the DNA target in order to stabilize the protein-DNA complex [PubMed11780147]. Protein interactions may also serve to stabilize the protein-DNA complex, for example in the STAT-1 dimer the SH2 (Src homology 2) domain in each monomer is coupled to the DNA-binding domain to increase stability [PubMed9630226]. The DNA-binding domain consists of a beta-sandwich formed of 9 strands in 2 sheets with a Greek-key topology. This structure is found in many transcription factors, often within the DNA-binding domain.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 19 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a p53-like transcription factors domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 19 hidden Markov models representing the p53-like transcription factors superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]