SUPERFAMILY 1.75 HMM library and genome assignments server


p53-like transcription factors superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Common fold of diphtheria toxin/transcription factors/cytochrome f [ 49379] (10)
Superfamily:   p53-like transcription factors [ 49417] (7)
Families:   p53 DNA-binding domain-like [ 81314] (2)
  Rel/Dorsal transcription factors, DNA-binding domain [ 81315] (6)
  T-box [ 81316] (2)
  STAT DNA-binding domain [ 81317] (3)
  RUNT domain [ 81318]
  DNA-binding domain from NDT80 [ 81992]
  DNA-binding protein LAG-1 (CSL) [ 110080]


Superfamily statistics
Genomes (336) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 5,702 6,312 53
Proteins 5,602 6,255 53


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process6.289e-120Least InformativeDirect
Biological Process (BP)developmental process2.806e-110Least InformativeDirect
Biological Process (BP)regulation of cellular process6.451e-108.96e-12Least InformativeDirect
Biological Process (BP)response to stimulus0.00054810Least InformativeDirect
Biological Process (BP)regulation of metabolic process0.0023690Least InformativeInherited
Biological Process (BP)single-organism cellular process0.0061337.333e-15Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.070480Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.072290Least InformativeInherited
Biological Process (BP)biosynthetic process0.096495.74e-09Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.097650Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.15061.119e-12Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.11021.4e-10Least InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process6.503e-140Moderately InformativeDirect
Biological Process (BP)cell differentiation3.712e-130Moderately InformativeDirect
Biological Process (BP)single-organism developmental process5.048e-070Moderately InformativeDirect
Biological Process (BP)positive regulation of cellular process8.747e-060Moderately InformativeDirect
Biological Process (BP)positive regulation of metabolic process5.218e-050Moderately InformativeDirect
Biological Process (BP)regulation of multicellular organismal process6.782e-050Moderately InformativeDirect
Biological Process (BP)anatomical structure morphogenesis0.00027183.752e-09Moderately InformativeDirect
Biological Process (BP)immune system process0.0006280Moderately InformativeDirect
Biological Process (BP)regulation of developmental process0.00068530Moderately InformativeDirect
Biological Process (BP)organ development0.00086860Moderately InformativeDirect
Biological Process (BP)regulation of signal transduction0.019160.0001867Moderately InformativeInherited
Biological Process (BP)regulation of programmed cell death1.803e-060.1054Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process0.0019560Moderately InformativeInherited
Biological Process (BP)cellular nitrogen compound biosynthetic process0.0024930Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process0.0027460Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process0.0044760Moderately InformativeInherited
Biological Process (BP)RNA metabolic process0.0010770Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process0.0043560Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process0.034870.07023Moderately InformativeInherited
Biological Process (BP)regulation of macromolecule biosynthetic process0.002730Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.028360Moderately InformativeInherited
Biological Process (BP)cellular macromolecule biosynthetic process0.0018210Moderately InformativeInherited
Biological Process (BP)gene expression0.0024430Moderately InformativeInherited
Biological Process (BP)tissue development0.0010731.431e-14Moderately InformativeInherited
Biological Process (BP)positive regulation of nitrogen compound metabolic process4.061e-060InformativeDirect
Biological Process (BP)transcription, DNA-dependent5.903e-060InformativeDirect
Biological Process (BP)organ morphogenesis4.407e-051.391e-12InformativeDirect
Biological Process (BP)positive regulation of gene expression0.0001060InformativeDirect
Biological Process (BP)embryonic morphogenesis0.00012140InformativeDirect
Biological Process (BP)embryonic organ development0.00015150InformativeDirect
Biological Process (BP)positive regulation of macromolecule biosynthetic process0.00019290InformativeDirect
Biological Process (BP)positive regulation of cellular biosynthetic process0.00033660InformativeDirect
Biological Process (BP)regulation of apoptotic signaling pathway0.00058013.252e-10InformativeDirect
Biological Process (BP)embryo development ending in birth or egg hatching1.829e-100.1798InformativeInherited
Biological Process (BP)muscle structure development0.0023666.183e-06InformativeInherited
Biological Process (BP)cell activation0.0016530InformativeInherited
Biological Process (BP)hematopoietic or lymphoid organ development0.0091680InformativeInherited
Biological Process (BP)cardiovascular system development0.0092642.112e-14InformativeInherited
Biological Process (BP)hair follicle development8.729e-090Highly InformativeDirect
Biological Process (BP)cell fate commitment2.853e-051.02e-12Highly InformativeDirect
Biological Process (BP)pattern specification process8.624e-050Highly InformativeDirect
Biological Process (BP)positive regulation of transcription, DNA-dependent9.44e-050Highly InformativeDirect
Biological Process (BP)stem cell development0.00029713.292e-13Highly InformativeDirect
Molecular Function (MF)binding1.493e-050Least InformativeDirect
Molecular Function (MF)nucleic acid binding1.147e-130Moderately InformativeDirect
Molecular Function (MF)nucleic acid binding transcription factor activity00InformativeDirect
Molecular Function (MF)DNA binding00InformativeDirect
Molecular Function (MF)chromatin binding2.493e-090InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle8.582e-080Least InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 8.96e-12 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 7.333e-15 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 0 Least Informative Direct
Biological Process (BP) biosynthetic process 5.74e-09 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 1.4e-10 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 1.119e-12 Least Informative Direct
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 0.06933 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.72 Least Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) cell differentiation 0 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 0 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 3.752e-09 Moderately Informative Direct
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0 Moderately Informative Direct
Biological Process (BP) organ development 0 Moderately Informative Direct
Biological Process (BP) tissue development 1.431e-14 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 0 Moderately Informative Direct
Biological Process (BP) multi-organism process 1.575e-07 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) gene expression 0 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 1.858e-06 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0.0001867 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 1.473e-09 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0 Moderately Informative Direct
Biological Process (BP) response to organic substance 8.729e-07 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 1.259e-06 Moderately Informative Direct
Biological Process (BP) signal transduction 0.0001161 Moderately Informative Direct
Biological Process (BP) reproduction 1.242e-08 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.0004598 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 0.0007575 Moderately Informative Direct
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of programmed cell death 0.1054 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.02139 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.1532 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.07023 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.009716 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.6149 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0 Informative Direct
Biological Process (BP) transcription, DNA-dependent 0 Informative Direct
Biological Process (BP) organ morphogenesis 1.391e-12 Informative Direct
Biological Process (BP) positive regulation of gene expression 0 Informative Direct
Biological Process (BP) embryonic morphogenesis 0 Informative Direct
Biological Process (BP) embryonic organ development 0 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0 Informative Direct
Biological Process (BP) regulation of apoptotic signaling pathway 3.252e-10 Informative Direct
Biological Process (BP) negative regulation of signaling 0.0004052 Informative Direct
Biological Process (BP) cell activation 0 Informative Direct
Biological Process (BP) tissue morphogenesis 2.78e-14 Informative Direct
Biological Process (BP) muscle structure development 6.183e-06 Informative Direct
Biological Process (BP) negative regulation of developmental process 0 Informative Direct
Biological Process (BP) central nervous system development 0.0001843 Informative Direct
Biological Process (BP) hematopoietic or lymphoid organ development 0 Informative Direct
Biological Process (BP) cardiovascular system development 2.112e-14 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 1.642e-09 Informative Direct
Biological Process (BP) positive regulation of cell proliferation 9.192e-10 Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0 Informative Direct
Biological Process (BP) cell death 0 Informative Direct
Biological Process (BP) response to cytokine stimulus 0 Informative Direct
Biological Process (BP) intracellular signal transduction 2.112e-14 Informative Direct
Biological Process (BP) response to nutrient levels 2.433e-11 Informative Direct
Biological Process (BP) regulation of growth 1.773e-10 Informative Direct
Biological Process (BP) regulation of peptidase activity 2.311e-10 Informative Direct
Biological Process (BP) immune response 2.396e-10 Informative Direct
Biological Process (BP) gland development 2.447e-09 Informative Direct
Biological Process (BP) response to DNA damage stimulus 1.102e-08 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 9.177e-07 Informative Direct
Biological Process (BP) mitochondrion organization 2.346e-06 Informative Direct
Biological Process (BP) response to bacterium 1.351e-05 Informative Direct
Biological Process (BP) protein localization to organelle 6.116e-05 Informative Direct
Biological Process (BP) protein transport 0.0001611 Informative Direct
Biological Process (BP) locomotion 0.0001898 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.0002044 Informative Direct
Biological Process (BP) lipid localization 0.00026 Informative Direct
Biological Process (BP) negative regulation of cell death 0.0004606 Informative Direct
Biological Process (BP) response to organonitrogen compound 0.000595 Informative Direct
Biological Process (BP) DNA metabolic process 0.0007795 Informative Direct
Biological Process (BP) cellular response to endogenous stimulus 0.0008609 Informative Direct
Biological Process (BP) regulation of cell development 1 Informative Inherited
Biological Process (BP) generation of neurons 0.09928 Informative Inherited
Biological Process (BP) regulation of nervous system development 1 Informative Inherited
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) regulation of secretion 0.1132 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.8794 Informative Inherited
Biological Process (BP) regulation of locomotion 0.9869 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.01012 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.09144 Informative Inherited
Biological Process (BP) response to inorganic substance 0.812 Informative Inherited
Biological Process (BP) metal ion transport 0.06732 Informative Inherited
Biological Process (BP) muscle tissue development 0.7792 Informative Inherited
Biological Process (BP) sensory organ development 0.2964 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.02526 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) reproductive structure development 1 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.7697 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.6078 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.5252 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.001221 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.1798 Informative Inherited
Biological Process (BP) single-organism behavior 1 Informative Inherited
Biological Process (BP) membrane organization 0.002454 Informative Inherited
Biological Process (BP) positive regulation of immune system process 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.003323 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.005544 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.183 Informative Inherited
Biological Process (BP) energy derivation by oxidation of organic compounds 0.002204 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.3827 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 1 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.0221 Informative Inherited
Biological Process (BP) single organism reproductive process 0.3525 Informative Inherited
Biological Process (BP) steroid metabolic process 0.5213 Informative Inherited
Biological Process (BP) cellular ketone metabolic process 0.01352 Informative Inherited
Biological Process (BP) regulation of immune effector process 0.04508 Informative Inherited
Biological Process (BP) positive regulation of protein metabolic process 1 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.8703 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) regulation of defense response 1 Informative Inherited
Biological Process (BP) response to lipid 0.5244 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.07253 Informative Inherited
Biological Process (BP) regulation of cell cycle 0.07437 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.3073 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.615 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) response to light stimulus 0.1484 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.07312 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.5292 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 1 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.08884 Informative Inherited
Biological Process (BP) cell-cell signaling 1 Informative Inherited
Biological Process (BP) cell cycle process 0.1985 Informative Inherited
Biological Process (BP) immune effector process 1 Informative Inherited
Biological Process (BP) localization of cell 0.002854 Informative Inherited
Biological Process (BP) cellular component movement 0.6586 Informative Inherited
Biological Process (BP) cellular component morphogenesis 1 Informative Inherited
Biological Process (BP) hair follicle development 0 Highly Informative Direct
Biological Process (BP) cell fate commitment 1.02e-12 Highly Informative Direct
Biological Process (BP) pattern specification process 0 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-dependent 0 Highly Informative Direct
Biological Process (BP) stem cell development 3.292e-13 Highly Informative Direct
Biological Process (BP) skeletal system development 1.326e-08 Highly Informative Direct
Biological Process (BP) negative regulation of cell differentiation 0 Highly Informative Direct
Biological Process (BP) cytokine-mediated signaling pathway 0 Highly Informative Direct
Biological Process (BP) regulation of epithelial cell differentiation 0 Highly Informative Direct
Biological Process (BP) positive regulation of peptidase activity 0 Highly Informative Direct
Biological Process (BP) mesenchyme development 0 Highly Informative Direct
Biological Process (BP) cell proliferation 0 Highly Informative Direct
Biological Process (BP) regulation of cysteine-type endopeptidase activity 3.746e-15 Highly Informative Direct
Biological Process (BP) aging 1.086e-14 Highly Informative Direct
Biological Process (BP) regulation of mitochondrion organization 2.112e-14 Highly Informative Direct
Biological Process (BP) response to UV 5.464e-13 Highly Informative Direct
Biological Process (BP) response to ionizing radiation 3.716e-12 Highly Informative Direct
Biological Process (BP) protein targeting to nucleus 6.396e-12 Highly Informative Direct
Biological Process (BP) regulation of G1/S transition of mitotic cell cycle 5.378e-11 Highly Informative Direct
Biological Process (BP) protein localization to nucleus 1.68e-10 Highly Informative Direct
Biological Process (BP) nuclear import 1.691e-10 Highly Informative Direct
Biological Process (BP) carbohydrate homeostasis 2.575e-10 Highly Informative Direct
Biological Process (BP) response to peptide hormone stimulus 3.783e-10 Highly Informative Direct
Biological Process (BP) regulation of mononuclear cell proliferation 6.629e-09 Highly Informative Direct
Biological Process (BP) protein import 9.644e-09 Highly Informative Direct
Biological Process (BP) cardiocyte differentiation 2.087e-08 Highly Informative Direct
Biological Process (BP) regulation of autophagy 3.319e-08 Highly Informative Direct
Biological Process (BP) cellular response to radiation 3.52e-08 Highly Informative Direct
Biological Process (BP) response to purine-containing compound 3.763e-08 Highly Informative Direct
Biological Process (BP) negative regulation of cellular catabolic process 9.539e-08 Highly Informative Direct
Biological Process (BP) lactation 2.812e-07 Highly Informative Direct
Biological Process (BP) mitochondrial transport 3.16e-07 Highly Informative Direct
Biological Process (BP) development of primary female sexual characteristics 6.425e-07 Highly Informative Direct
Biological Process (BP) regulation of lymphocyte mediated immunity 1.252e-06 Highly Informative Direct
Biological Process (BP) cell cycle checkpoint 1.349e-06 Highly Informative Direct
Biological Process (BP) intrinsic apoptotic signaling pathway 1.849e-06 Highly Informative Direct
Biological Process (BP) ovulation cycle process 3.92e-06 Highly Informative Direct
Biological Process (BP) regulation of cytokine biosynthetic process 3.923e-06 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 4.295e-06 Highly Informative Direct
Biological Process (BP) angiogenesis 5.722e-06 Highly Informative Direct
Biological Process (BP) cellular response to metal ion 6.425e-06 Highly Informative Direct
Biological Process (BP) limb morphogenesis 6.871e-06 Highly Informative Direct
Biological Process (BP) regulation of multicellular organism growth 1.132e-05 Highly Informative Direct
Biological Process (BP) regulation of smooth muscle cell proliferation 1.721e-05 Highly Informative Direct
Biological Process (BP) mitotic cell cycle phase transition 3.455e-05 Highly Informative Direct
Biological Process (BP) photoreceptor cell differentiation 9.309e-05 Highly Informative Direct
Biological Process (BP) cellular response to peptide 0.0001402 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0.0001923 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 0.000274 Highly Informative Direct
Biological Process (BP) regulation of organ morphogenesis 0.0002988 Highly Informative Direct
Biological Process (BP) calcium ion transport 0.0003068 Highly Informative Direct
Biological Process (BP) renal system development 0.0003656 Highly Informative Direct
Biological Process (BP) positive regulation of defense response 0.0006601 Highly Informative Direct
Biological Process (BP) endocrine system development 0.0007181 Highly Informative Direct
Biological Process (BP) positive regulation of apoptotic signaling pathway 0.0008243 Highly Informative Direct
Biological Process (BP) leukocyte homeostasis 0.0009508 Highly Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 1 Highly Informative Inherited
Biological Process (BP) negative regulation of secretion 0.001301 Highly Informative Inherited
Biological Process (BP) regulation of synaptic transmission 1 Highly Informative Inherited
Biological Process (BP) regulation of neural precursor cell proliferation 0.2832 Highly Informative Inherited
Biological Process (BP) negative regulation of cellular component movement 0.01242 Highly Informative Inherited
Biological Process (BP) negative regulation of locomotion 0.01 Highly Informative Inherited
Biological Process (BP) negative regulation of mitotic cell cycle phase transition 0.01115 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 0.0883 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.02831 Highly Informative Inherited
Biological Process (BP) inner ear development 0.01796 Highly Informative Inherited
Biological Process (BP) positive regulation of cell cycle process 0.7184 Highly Informative Inherited
Biological Process (BP) regulation of calcium-mediated signaling 0.02548 Highly Informative Inherited
Biological Process (BP) positive regulation of programmed cell death 1 Highly Informative Inherited
Biological Process (BP) artery morphogenesis 0.00765 Highly Informative Inherited
Biological Process (BP) cardiac muscle tissue development 0.5846 Highly Informative Inherited
Biological Process (BP) morphogenesis of a branching epithelium 0.2197 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 1 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 1 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 1 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.001654 Highly Informative Inherited
Biological Process (BP) glial cell differentiation 0.5054 Highly Informative Inherited
Biological Process (BP) cell cycle phase 0.004271 Highly Informative Inherited
Biological Process (BP) sensory perception 0.001221 Highly Informative Inherited
Biological Process (BP) positive regulation of response to external stimulus 0.001291 Highly Informative Inherited
Biological Process (BP) regulation of inflammatory response 0.0657 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 0.001594 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 0.8178 Highly Informative Inherited
Biological Process (BP) positive regulation of cell activation 0.3737 Highly Informative Inherited
Biological Process (BP) regulation of myeloid cell differentiation 0.005399 Highly Informative Inherited
Biological Process (BP) positive regulation of cell differentiation 0.1273 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 0.0818 Highly Informative Inherited
Biological Process (BP) alpha-beta T cell activation 0.4034 Highly Informative Inherited
Biological Process (BP) regulation of neuron apoptotic process 0.9703 Highly Informative Inherited
Biological Process (BP) cellular hormone metabolic process 0.01783 Highly Informative Inherited
Biological Process (BP) regulation of cell killing 0.07012 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.7389 Highly Informative Inherited
Biological Process (BP) hormone-mediated signaling pathway 0.3046 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.1335 Highly Informative Inherited
Biological Process (BP) immune response-regulating signaling pathway 0.8984 Highly Informative Inherited
Biological Process (BP) regulation of innate immune response 0.1685 Highly Informative Inherited
Biological Process (BP) activation of immune response 1 Highly Informative Inherited
Biological Process (BP) positive regulation of leukocyte proliferation 0.5681 Highly Informative Inherited
Biological Process (BP) response to lipopolysaccharide 0.01195 Highly Informative Inherited
Biological Process (BP) negative regulation of growth 0.004343 Highly Informative Inherited
Biological Process (BP) regulation of cell growth 0.01063 Highly Informative Inherited
Biological Process (BP) epidermal cell differentiation 0.8706 Highly Informative Inherited
Biological Process (BP) regulation of cell adhesion 0.01168 Highly Informative Inherited
Biological Process (BP) regulation of response to nutrient levels 1 Highly Informative Inherited
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.5667 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.01878 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 1 Highly Informative Inherited
Biological Process (BP) cell division 0.4792 Highly Informative Inherited
Biological Process (BP) response to osmotic stress 0.007051 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 0.3094 Highly Informative Inherited
Biological Process (BP) negative regulation of cell cycle 0.006012 Highly Informative Inherited
Biological Process (BP) heart morphogenesis 0.004469 Highly Informative Inherited
Biological Process (BP) regulation of humoral immune response 0.02362 Highly Informative Inherited
Biological Process (BP) regulation of response to biotic stimulus 0.7429 Highly Informative Inherited
Biological Process (BP) regulation of multi-organism process 1 Highly Informative Inherited
Biological Process (BP) positive regulation of leukocyte mediated immunity 0.4667 Highly Informative Inherited
Biological Process (BP) T cell differentiation 0.00755 Highly Informative Inherited
Biological Process (BP) B cell activation 0.8489 Highly Informative Inherited
Biological Process (BP) leukocyte activation involved in immune response 0.007435 Highly Informative Inherited
Biological Process (BP) connective tissue development 0.4977 Highly Informative Inherited
Biological Process (BP) ossification 0.2537 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 1 Highly Informative Inherited
Biological Process (BP) myeloid leukocyte activation 1 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 0.7537 Highly Informative Inherited
Biological Process (BP) gonad development 0.3829 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) nucleic acid binding 0 Moderately Informative Direct
Molecular Function (MF) cation binding 3.86e-05 Moderately Informative Direct
Molecular Function (MF) anion binding 0.002959 Moderately Informative Inherited
Molecular Function (MF) enzyme regulator activity 0.4141 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding transcription factor activity 0 Informative Direct
Molecular Function (MF) DNA binding 0 Informative Direct
Molecular Function (MF) chromatin binding 0 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 5.73e-09 Informative Direct
Molecular Function (MF) purine ribonucleoside binding 1.541e-08 Informative Direct
Molecular Function (MF) nucleotide binding 6.1e-06 Informative Direct
Molecular Function (MF) protein dimerization activity 2.051e-05 Informative Direct
Molecular Function (MF) transition metal ion binding 0.000163 Informative Direct
Molecular Function (MF) enzyme binding 0.2254 Informative Inherited
Molecular Function (MF) transcription factor binding 0 Highly Informative Direct
Molecular Function (MF) copper ion binding 1.327e-12 Highly Informative Direct
Molecular Function (MF) ATP binding 4.169e-12 Highly Informative Direct
Molecular Function (MF) transcription factor binding transcription factor activity 3.958e-08 Highly Informative Direct
Molecular Function (MF) transcription regulatory region DNA binding 1 Highly Informative Inherited
Molecular Function (MF) sequence-specific DNA binding transcription factor activity 1 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) protein complex 7.462e-06 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.2546 Least Informative Inherited
Cellular Component (CC) cytosol 0 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 0 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.0004427 Moderately Informative Direct
Cellular Component (CC) extracellular region part 1 Moderately Informative Inherited
Cellular Component (CC) nucleolus 4.126e-07 Informative Direct
Cellular Component (CC) nucleoplasm part 5.226e-05 Informative Direct
Cellular Component (CC) chromosome 7.948e-05 Informative Direct
Cellular Component (CC) extracellular matrix 0.1378 Informative Inherited
Cellular Component (CC) transcription factor complex 0 Highly Informative Direct
Cellular Component (CC) extracellular matrix part 0.004397 Highly Informative Inherited
Cellular Component (CC) proteinaceous extracellular matrix 0.01466 Highly Informative Inherited

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.0825Least InformativeInherited
Disease Ontology (DO)hematologic cancer0.001499Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.01059Moderately InformativeInherited
Disease Ontology (DO)genetic disease0.018Moderately InformativeInherited
Disease Ontology (DO)benign neoplasm0.02405Moderately InformativeInherited
Disease Ontology (DO)bacterial infectious disease0.1214Moderately InformativeInherited
Disease Ontology (DO)inflammatory bowel disease3.097e-06InformativeDirect
Disease Ontology (DO)chronic leukemia0.0003628InformativeDirect
Disease Ontology (DO)autosomal dominant disease0.0004903InformativeDirect
Disease Ontology (DO)laryngeal carcinoma0.0005849InformativeDirect
Disease Ontology (DO)physical disorder0.00102InformativeInherited
Disease Ontology (DO)renal carcinoma0.002081InformativeInherited
Disease Ontology (DO)lymphoma0.007428InformativeInherited
Disease Ontology (DO)large intestine cancer0.008067InformativeInherited
Disease Ontology (DO)esophageal disease0.008214InformativeInherited
Disease Ontology (DO)viral infectious disease0.2617InformativeInherited
Disease Ontology (DO)breast carcinoma0.3006InformativeInherited
Disease Ontology (DO)ulcerative colitis9.516e-08Highly InformativeDirect
Disease Ontology (DO)Burkitt's lymphoma3.258e-05Highly InformativeDirect
Disease Ontology (DO)mumps8.783e-05Highly InformativeDirect
Disease Ontology (DO)progressive multifocal leukoencephalopathy0.0004663Highly InformativeDirect
Disease Ontology (DO)pertussis0.0005158Highly InformativeDirect
Disease Ontology (DO)hemangioma0.0006006Highly InformativeDirect
Disease Ontology (DO)stomach disease0.005485Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the skeletal system0.0548Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of head and neck0.1256Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the hand0.022Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the mouth0.1942Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the oral cavity0.01609InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia involving bones of the hand0.05219InformativeInherited
Phenotypic Abnormality (PA)Absent hand0.0002001Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the humerus0.0008151Highly InformativeDirect
Phenotypic Abnormality (PA)Oral cleft0.008763Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the palate0.0471Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging2.595e-06Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0.0001008Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0.0002711Least InformativeDirect
Mammalian Phenotype (MP)hematopoietic system phenotype0.001267Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.004132Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.04903Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.05135Least InformativeInherited
Mammalian Phenotype (MP)digestive/alimentary phenotype7.758e-09Moderately InformativeDirect
Mammalian Phenotype (MP)respiratory system phenotype6.276e-08Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal skeleton morphology2.079e-07Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal mononuclear cell morphology5.777e-06Moderately InformativeDirect
Mammalian Phenotype (MP)integument phenotype9.141e-06Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal leukopoiesis1.111e-05Moderately InformativeDirect
Mammalian Phenotype (MP)muscle phenotype0.0004304Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal inflammatory response0.0006444Moderately InformativeDirect
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.001192Moderately InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.001344Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.002847Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune cell physiology0.003335Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell-mediated immunity0.003782Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal adaptive immunity0.00479Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic system physiology0.005337Moderately InformativeInherited
Mammalian Phenotype (MP)tumorigenesis0.006122Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.02604Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.03218Moderately InformativeInherited
Mammalian Phenotype (MP)preweaning lethality0.03295Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.07513Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell morphology0.0971Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.1145Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.1828Moderately InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to infection0.5659Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.7198Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal T cell morphology4.616e-10InformativeDirect
Mammalian Phenotype (MP)abnormal interleukin level1.481e-08InformativeDirect
Mammalian Phenotype (MP)increased susceptibility to infection1.713e-06InformativeDirect
Mammalian Phenotype (MP)abnormal thymus morphology1.728e-05InformativeDirect
Mammalian Phenotype (MP)abnormal fluid regulation0.0001277InformativeDirect
Mammalian Phenotype (MP)hemorrhage0.0002715InformativeDirect
Mammalian Phenotype (MP)abnormal cranium morphology0.0002767InformativeDirect
Mammalian Phenotype (MP)abnormal cell differentiation0.0004671InformativeDirect
Mammalian Phenotype (MP)increased leukocyte cell number0.0009478InformativeDirect
Mammalian Phenotype (MP)abnormal hepatobiliary system physiology0.002895InformativeInherited
Mammalian Phenotype (MP)abnormal humoral immune response0.003664InformativeInherited
Mammalian Phenotype (MP)abnormal cartilage morphology0.005931InformativeInherited
Mammalian Phenotype (MP)abnormal antigen presentation0.01357InformativeInherited
Mammalian Phenotype (MP)abnormal lymph node morphology0.02134InformativeInherited
Mammalian Phenotype (MP)abnormal mammary gland morphology0.02225InformativeInherited
Mammalian Phenotype (MP)abnormal circulating cytokine level0.02877InformativeInherited
Mammalian Phenotype (MP)abnormal epidermal layer morphology0.04355InformativeInherited
Mammalian Phenotype (MP)abnormal interferon level0.07129InformativeInherited
Mammalian Phenotype (MP)lethality during fetal growth through weaning0.08116InformativeInherited
Mammalian Phenotype (MP)abnormal B cell physiology0.08404InformativeInherited
Mammalian Phenotype (MP)decreased hematopoietic cell number0.1037InformativeInherited
Mammalian Phenotype (MP)abnormal appendicular skeleton morphology0.1705InformativeInherited
Mammalian Phenotype (MP)increased hemolymphoid system tumor incidence0.2049InformativeInherited
Mammalian Phenotype (MP)abnormal stomach morphology0.2836InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation0.3203InformativeInherited
Mammalian Phenotype (MP)abnormal voluntary movement0.3557InformativeInherited
Mammalian Phenotype (MP)abnormal head morphology0.3562InformativeInherited
Mammalian Phenotype (MP)abnormal induced cell death0.5895InformativeInherited
Mammalian Phenotype (MP)embryonic lethality0.6547InformativeInherited
Mammalian Phenotype (MP)abnormal vertebrae morphology0.6628InformativeInherited
Mammalian Phenotype (MP)abnormal Peyer's patch morphology0.8867InformativeInherited
Mammalian Phenotype (MP)decreased B cell proliferation1.045e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal erythrocyte morphology1.623e-05Highly InformativeDirect
Mammalian Phenotype (MP)respiratory system inflammation4.352e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mammary gland development5.322e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal dendritic cell number5.328e-05Highly InformativeDirect
Mammalian Phenotype (MP)decreased IgG level7.627e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal secondary palate development7.696e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal intervertebral disk morphology0.0001071Highly InformativeDirect
Mammalian Phenotype (MP)cleft palate0.0001574Highly InformativeDirect
Mammalian Phenotype (MP)abnormal stomach epithelium morphology0.0001685Highly InformativeDirect
Mammalian Phenotype (MP)complete lethality throughout fetal growth and development0.0002037Highly InformativeDirect
Mammalian Phenotype (MP)impaired adaptive thermogenesis0.0002083Highly InformativeDirect
Mammalian Phenotype (MP)abnormal vertebral arch morphology0.0002171Highly InformativeDirect
Mammalian Phenotype (MP)abnormal thymus medulla morphology0.0002294Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cervical atlas morphology0.0002534Highly InformativeDirect
Mammalian Phenotype (MP)abnormal level of surface class II molecules0.0004066Highly InformativeDirect
Mammalian Phenotype (MP)abnormal neutrophil cell number0.0004268Highly InformativeDirect
Mammalian Phenotype (MP)impaired natural killer cell mediated cytotoxicity0.0004357Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mammary gland alveolus morphology0.0005348Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating insulin-like growth factor I level0.0006657Highly InformativeDirect
Mammalian Phenotype (MP)no abnormal phenotype detected0.0009363Highly InformativeDirect
Mammalian Phenotype (MP)increased leukemia incidence0.005701Highly InformativeInherited
Mammalian Phenotype (MP)abnormal spinal cord morphology0.005711Highly InformativeInherited
Mammalian Phenotype (MP)decreased sensitivity to induced cell death0.008837Highly InformativeInherited
Mammalian Phenotype (MP)abnormal clavicle morphology0.02175Highly InformativeInherited
Mammalian Phenotype (MP)embryonic lethality during organogenesis0.04264Highly InformativeInherited
Mammalian Phenotype (MP)abnormal bone marrow cell morphology/development0.07696Highly InformativeInherited
Mammalian Phenotype (MP)abnormal Peyer's patch size0.1147Highly InformativeInherited
Mammalian Phenotype (MP)abnormal epidermis stratum spinosum morphology0.1499Highly InformativeInherited
Mammalian Phenotype (MP)abnormal peripheral lymph node morphology0.2125Highly InformativeInherited
Mammalian Phenotype (MP)abnormal sternum morphology0.8812Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.791Least InformativeInherited
Worm Phenotype (WP)alimentary system morphology variant0.0007835Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased cell number0.0009016InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)anatomical group0.01385Least InformativeInherited
Fly Anatomy (FA)larva0.05062Least InformativeInherited
Fly Anatomy (FA)cell0.08992Least InformativeInherited
Fly Anatomy (FA)organ system0.1076Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)late embryo0.2301Moderately InformativeInherited
Fly Anatomy (FA)mechanosensory system0.000678InformativeDirect
Fly Anatomy (FA)circulatory system0.00112InformativeInherited
Fly Anatomy (FA)head mesoderm derived embryonic hemocyte9.521e-05Highly InformativeDirect
Fly Anatomy (FA)embryonic/larval circulatory system0.0002735Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)portion of tissue0.1333Least InformativeInherited
Zebrafish Anatomy (ZA)paraxial mesoderm1.831e-05InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.09074Least InformativeInherited
Xenopus ANatomical entity (XAN)portion of tissue0.4631Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.743Least InformativeInherited
Xenopus ANatomical entity (XAN)viscus0.8744Least InformativeInherited
Xenopus ANatomical entity (XAN)cell1Least InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.001614Moderately InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.055Moderately InformativeInherited
Xenopus ANatomical entity (XAN)surface structure0.09878Moderately InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.1835Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.7556Moderately InformativeInherited
Xenopus ANatomical entity (XAN)visual system0.9957Moderately InformativeInherited
Xenopus ANatomical entity (XAN)notochord9.296e-06InformativeDirect
Xenopus ANatomical entity (XAN)anatomical direction1.446e-05InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0.0003474InformativeDirect
Xenopus ANatomical entity (XAN)vestibuloauditory system0.0004739InformativeDirect
Xenopus ANatomical entity (XAN)neural plate0.0005225InformativeDirect
Xenopus ANatomical entity (XAN)pharyngeal region0.00065InformativeDirect
Xenopus ANatomical entity (XAN)heart0.3535InformativeInherited
Xenopus ANatomical entity (XAN)involuted ventral mesoderm1.41e-07Highly InformativeDirect
Xenopus ANatomical entity (XAN)mesenchyme2.358e-06Highly InformativeDirect
Xenopus ANatomical entity (XAN)fused heart primordium3.499e-06Highly InformativeDirect
Xenopus ANatomical entity (XAN)appendage1.194e-05Highly InformativeDirect
Xenopus ANatomical entity (XAN)limb bud4.46e-05Highly InformativeDirect
Xenopus ANatomical entity (XAN)involuted dorsal mesoderm7.291e-05Highly InformativeDirect
Xenopus ANatomical entity (XAN)otic vesicle0.0002338Highly InformativeDirect
Xenopus ANatomical entity (XAN)optic vesicle0.0007348Highly InformativeDirect
Xenopus ANatomical entity (XAN)marginal zone0.7042Highly InformativeInherited
Xenopus DEvelopment stage (XDE)embryonic stage0.0006898Least InformativeDirect

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis0Moderately InformativeDirect
Biological processTranscription regulation0Moderately InformativeDirect
Biological processCell cycle5.075e-12Moderately InformativeDirect
Biological processNotch signaling pathway0Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentEndoplasmic reticulum1.468e-09Moderately InformativeDirect
Coding sequence diversityAlternative promoter usage0.0001085Moderately InformativeDirect
DiseaseTumor suppressor0Moderately InformativeDirect
DomainSH2 domain0InformativeDirect
DomainANK repeat1.206e-07InformativeDirect
Molecular functionDNA-binding0Least InformativeDirect
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationRepressor4.283e-10Moderately InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationAcetylation9.416e-10Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationIsopeptide bond0Moderately InformativeDirect
Post-translational modificationMethylation1.718e-06Moderately InformativeDirect
Post-translational modificationS-nitrosylation8.927e-06InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR008967 SSF49417 Protein matches
Abstract

This domain is found in a number of transcription factors, including p53, NFATC, TonEBP, STAT-1, and NFkappaB, where it is responsible for DNA-binding. These transcription factors play diverse roles in the regulation of cellular functions: the p53 tumour suppressor upregulates the expression of genes involved in cell cycle arrest and apoptosis [PubMed12826037]; NFATC regulates the production of effector proteins involved in coordinating the immune response [PubMed8990122]; TonEBP regulates gene expression induced by osmotic stress and helps regulate intracellular volume during cell growth [PubMed12729611]; STAT-1 plays an important role in B lymphocyte growth and function [PubMed12855573]; and NFkappaB is involved in the inflammatory response [PubMed12421671]. The DNA-binding domain acts to clamp, or in the case of TonEBP, encircle the DNA target in order to stabilize the protein-DNA complex [PubMed11780147]. Protein interactions may also serve to stabilize the protein-DNA complex, for example in the STAT-1 dimer the SH2 (Src homology 2) domain in each monomer is coupled to the DNA-binding domain to increase stability [PubMed9630226]. The DNA-binding domain consists of a beta-sandwich formed of 9 strands in 2 sheets with a Greek-key topology. This structure is found in many transcription factors, often within the DNA-binding domain.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 19 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a p53-like transcription factors domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 19 hidden Markov models representing the p53-like transcription factors superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]