SUPERFAMILY 1.75 HMM library and genome assignments server

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p53-like transcription factors superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Common fold of diphtheria toxin/transcription factors/cytochrome f [ 49379] (10)
Superfamily:   p53-like transcription factors [ 49417] (7)
Families:   p53 DNA-binding domain-like [ 81314] (2)
  Rel/Dorsal transcription factors, DNA-binding domain [ 81315] (6)
  T-box [ 81316] (2)
  STAT DNA-binding domain [ 81317] (3)
  RUNT domain [ 81318]
  DNA-binding domain from NDT80 [ 81992]
  DNA-binding protein LAG-1 (CSL) [ 110080]


Superfamily statistics
Genomes (359) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 6,139 7,648 53
Proteins 6,030 7,570 53


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process0.0000000000069650Least InformativeDirect
Biological Process (BP)developmental process0.00000000003120Least InformativeDirect
Biological Process (BP)regulation of cellular process0.0000000007960.000000000004448Least InformativeDirect
Biological Process (BP)response to stimulus0.0006240Least InformativeDirect
Biological Process (BP)regulation of metabolic process0.001990Least InformativeInherited
Biological Process (BP)single-organism cellular process0.0063680.000000000000003755Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.073170.00000000000004447Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.15320.0000000002009Least InformativeInherited
Biological Process (BP)biosynthetic process0.10030.0000004749Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.071950Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.099460.00000000000001086Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.10930.00000001545Least InformativeInherited
Biological Process (BP)immune system process0.00074750Moderately InformativeDirect
Biological Process (BP)anatomical structure morphogenesis0.00029670.000000001292Moderately InformativeDirect
Biological Process (BP)positive regulation of metabolic process0.000056250Moderately InformativeDirect
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.000000000000059390Moderately InformativeDirect
Biological Process (BP)cell differentiation0.00000000000052880Moderately InformativeDirect
Biological Process (BP)positive regulation of cellular process0.000010720Moderately InformativeDirect
Biological Process (BP)regulation of developmental process0.0006870Moderately InformativeDirect
Biological Process (BP)regulation of multicellular organismal process0.000081880Moderately InformativeDirect
Biological Process (BP)regulation of signal transduction0.018190.00009635Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process0.0030760Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process0.002180Moderately InformativeInherited
Biological Process (BP)cellular nitrogen compound biosynthetic process0.0028880Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process0.0048870Moderately InformativeInherited
Biological Process (BP)RNA metabolic process0.0010790Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process0.0044990Moderately InformativeInherited
Biological Process (BP)organ development0.0011030Moderately InformativeInherited
Biological Process (BP)regulation of macromolecule biosynthetic process0.0023910Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.029390Moderately InformativeInherited
Biological Process (BP)gene expression0.0025890Moderately InformativeInherited
Biological Process (BP)cellular macromolecule biosynthetic process0.0019080Moderately InformativeInherited
Biological Process (BP)tissue development0.00120.00000000000008316Moderately InformativeInherited
Biological Process (BP)transcription, DNA-dependent0.0000059270InformativeDirect
Biological Process (BP)organ morphogenesis0.000054830.000000000002007InformativeDirect
Biological Process (BP)positive regulation of macromolecule biosynthetic process0.00021420InformativeDirect
Biological Process (BP)positive regulation of gene expression0.00012070InformativeDirect
Biological Process (BP)positive regulation of cellular biosynthetic process0.00038920InformativeDirect
Biological Process (BP)positive regulation of nucleobase-containing compound metabolic process0.000004860InformativeDirect
Biological Process (BP)embryonic organ development0.00017610InformativeDirect
Biological Process (BP)embryonic morphogenesis0.00013130InformativeDirect
Biological Process (BP)regulation of apoptotic signaling pathway0.000029580InformativeDirect
Biological Process (BP)muscle structure development0.0027940.00002111InformativeInherited
Biological Process (BP)leukocyte activation0.0025170.000002829InformativeInherited
Biological Process (BP)hematopoietic or lymphoid organ development0.013710InformativeInherited
Biological Process (BP)cardiovascular system development0.0091180.00000000000001778InformativeInherited
Biological Process (BP)hair follicle development0.0000000077380.000000000000003755Highly InformativeDirect
Biological Process (BP)pattern specification process0.000090150Highly InformativeDirect
Biological Process (BP)cell fate commitment0.000019950.000000000000007347Highly InformativeDirect
Biological Process (BP)positive regulation of transcription, DNA-dependent0.00011140Highly InformativeDirect
Biological Process (BP)stem cell development0.0002950.000000000001586Highly InformativeDirect
Molecular Function (MF)binding0.000016740Least InformativeDirect
Molecular Function (MF)nucleic acid binding0.00000000000014030Moderately InformativeDirect
Molecular Function (MF)nucleic acid binding transcription factor activity00InformativeDirect
Molecular Function (MF)DNA binding00InformativeDirect
Molecular Function (MF)chromatin binding0.0000000023310InformativeDirect
Molecular Function (MF)transcription regulatory region DNA binding0.000000015211Highly InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.000000150Least InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0.00000000000004447 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.0000000002009 Least Informative Direct
Biological Process (BP) biosynthetic process 0.0000004749 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.00000001545 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.000000000000003755 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.000000000004448 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.00000000000001086 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.7115 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 0.1136 Least Informative Inherited
Biological Process (BP) reproduction 0.00000002209 Moderately Informative Direct
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) signal transduction 0.0001224 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.000000001292 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0.00000004549 Moderately Informative Direct
Biological Process (BP) tissue development 0.00000000000008316 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0.00009635 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.0000002258 Moderately Informative Direct
Biological Process (BP) gene expression 0 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 0 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) cell differentiation 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) organ development 0 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.0000000005213 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.000001426 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.0000005956 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 0.402 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.00136 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.05371 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.04999 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.01245 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.643 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.1996 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.8483 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) DNA metabolic process 0.0003723 Informative Direct
Biological Process (BP) transcription, DNA-dependent 0 Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0 Informative Direct
Biological Process (BP) apoptotic process 0 Informative Direct
Biological Process (BP) immune response 0.000000001203 Informative Direct
Biological Process (BP) response to DNA damage stimulus 0.0000002068 Informative Direct
Biological Process (BP) mitochondrion organization 0.0000001994 Informative Direct
Biological Process (BP) central nervous system development 0.0003991 Informative Direct
Biological Process (BP) response to bacterium 0.00001246 Informative Direct
Biological Process (BP) organ morphogenesis 0.000000000002007 Informative Direct
Biological Process (BP) response to organonitrogen compound 0.0005595 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0 Informative Direct
Biological Process (BP) positive regulation of gene expression 0 Informative Direct
Biological Process (BP) lipid localization 0.0002376 Informative Direct
Biological Process (BP) protein transport 0.0002823 Informative Direct
Biological Process (BP) negative regulation of signaling 0.0003907 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0 Informative Direct
Biological Process (BP) response to nutrient levels 0.0000000001693 Informative Direct
Biological Process (BP) protein localization to organelle 0.00009501 Informative Direct
Biological Process (BP) response to cytokine stimulus 0 Informative Direct
Biological Process (BP) tube development 0.000000000002371 Informative Direct
Biological Process (BP) intracellular signal transduction 0.00000000000001086 Informative Direct
Biological Process (BP) regulation of growth 0.0000000003472 Informative Direct
Biological Process (BP) locomotion 0.0004468 Informative Direct
Biological Process (BP) regulation of cell proliferation 0 Informative Direct
Biological Process (BP) leukocyte activation 0.000002829 Informative Direct
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 0 Informative Direct
Biological Process (BP) hematopoietic or lymphoid organ development 0 Informative Direct
Biological Process (BP) embryonic organ development 0 Informative Direct
Biological Process (BP) embryonic morphogenesis 0 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.000000008366 Informative Direct
Biological Process (BP) tissue morphogenesis 0.00000000000002963 Informative Direct
Biological Process (BP) gland development 0.000000003185 Informative Direct
Biological Process (BP) negative regulation of developmental process 0 Informative Direct
Biological Process (BP) regulation of peptidase activity 0.0000000000006627 Informative Direct
Biological Process (BP) negative regulation of cell death 0.0005252 Informative Direct
Biological Process (BP) muscle structure development 0.00002111 Informative Direct
Biological Process (BP) cellular response to endogenous stimulus 0.00005552 Informative Direct
Biological Process (BP) cardiovascular system development 0.00000000000001778 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.0005369 Informative Direct
Biological Process (BP) regulation of apoptotic signaling pathway 0 Informative Direct
Biological Process (BP) regulation of cell development 1 Informative Inherited
Biological Process (BP) generation of neurons 0.06423 Informative Inherited
Biological Process (BP) regulation of nervous system development 1 Informative Inherited
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) regulation of secretion 0.0893 Informative Inherited
Biological Process (BP) negative regulation of transport 0.8941 Informative Inherited
Biological Process (BP) regulation of vesicle-mediated transport 0.9996 Informative Inherited
Biological Process (BP) regulation of locomotion 1 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.8981 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.008337 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.1059 Informative Inherited
Biological Process (BP) response to inorganic substance 0.9088 Informative Inherited
Biological Process (BP) muscle tissue development 0.8365 Informative Inherited
Biological Process (BP) sensory organ development 0.3747 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.03286 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) reproductive system development 1 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.807 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.5895 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.509 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.001929 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.1991 Informative Inherited
Biological Process (BP) single-organism behavior 1 Informative Inherited
Biological Process (BP) cellular membrane organization 0.1598 Informative Inherited
Biological Process (BP) regulation of cell activation 0.1229 Informative Inherited
Biological Process (BP) positive regulation of immune system process 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.003367 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.003017 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.922 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.1331 Informative Inherited
Biological Process (BP) energy derivation by oxidation of organic compounds 0.002972 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.4243 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 1 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.7237 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.8318 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 1 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 1 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.01747 Informative Inherited
Biological Process (BP) single organism reproductive process 0.3803 Informative Inherited
Biological Process (BP) cellular ketone metabolic process 0.01189 Informative Inherited
Biological Process (BP) regulation of immune effector process 0.0593 Informative Inherited
Biological Process (BP) positive regulation of protein metabolic process 1 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.8268 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) regulation of defense response 1 Informative Inherited
Biological Process (BP) response to lipid 0.5993 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.085 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.1297 Informative Inherited
Biological Process (BP) regulation of cell cycle process 1 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.4007 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.6461 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.006948 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) response to light stimulus 0.1442 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.08616 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 1 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.5514 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.008835 Informative Inherited
Biological Process (BP) cell cycle process 0.1462 Informative Inherited
Biological Process (BP) metal ion transport 0.08965 Informative Inherited
Biological Process (BP) immune effector process 1 Informative Inherited
Biological Process (BP) cellular component movement 0.7731 Informative Inherited
Biological Process (BP) localization of cell 0.003837 Informative Inherited
Biological Process (BP) cellular component morphogenesis 1 Informative Inherited
Biological Process (BP) mitotic cell cycle 1 Informative Inherited
Biological Process (BP) skeletal system development 0.00000003668 Highly Informative Direct
Biological Process (BP) angiogenesis 0.000006444 Highly Informative Direct
Biological Process (BP) leukocyte homeostasis 0.0006286 Highly Informative Direct
Biological Process (BP) positive regulation of leukocyte mediated cytotoxicity 0.0001158 Highly Informative Direct
Biological Process (BP) hair follicle development 0.000000000000003755 Highly Informative Direct
Biological Process (BP) calcium ion transport 0.0004338 Highly Informative Direct
Biological Process (BP) mitochondrial transport 0.00000004842 Highly Informative Direct
Biological Process (BP) mitochondrial membrane organization 0.00000000003158 Highly Informative Direct
Biological Process (BP) pattern specification process 0 Highly Informative Direct
Biological Process (BP) aging 0 Highly Informative Direct
Biological Process (BP) lactation 0.000000326 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 0.000131 Highly Informative Direct
Biological Process (BP) response to UV 0.0000000000007324 Highly Informative Direct
Biological Process (BP) response to ionizing radiation 0.000000000004676 Highly Informative Direct
Biological Process (BP) regulation of autophagy 0.0000001223 Highly Informative Direct
Biological Process (BP) regulation of mitochondrion organization 0.000000000000007347 Highly Informative Direct
Biological Process (BP) positive regulation of endopeptidase activity 0.000567 Highly Informative Direct
Biological Process (BP) response to purine-containing compound 0.0000001388 Highly Informative Direct
Biological Process (BP) regulation of striated muscle tissue development 0 Highly Informative Direct
Biological Process (BP) protein import 0.00000001071 Highly Informative Direct
Biological Process (BP) regulation of exocytosis 0.00001584 Highly Informative Direct
Biological Process (BP) cytokine-mediated signaling pathway 0 Highly Informative Direct
Biological Process (BP) ovulation cycle process 0.000002712 Highly Informative Direct
Biological Process (BP) negative regulation of cell growth 0.000004289 Highly Informative Direct
Biological Process (BP) regulation of epithelial cell differentiation 0 Highly Informative Direct
Biological Process (BP) negative regulation of cellular catabolic process 0.000001169 Highly Informative Direct
Biological Process (BP) positive regulation of defense response 0.0005016 Highly Informative Direct
Biological Process (BP) regulation of mononuclear cell proliferation 0.00000001245 Highly Informative Direct
Biological Process (BP) carbohydrate homeostasis 0.0000000504 Highly Informative Direct
Biological Process (BP) protein localization to nucleus 0.0000000002483 Highly Informative Direct
Biological Process (BP) cardiocyte differentiation 0.000000003257 Highly Informative Direct
Biological Process (BP) limb morphogenesis 0.000003192 Highly Informative Direct
Biological Process (BP) endocrine system development 0.0006431 Highly Informative Direct
Biological Process (BP) regulation of multicellular organism growth 0.000007153 Highly Informative Direct
Biological Process (BP) regulation of cytokine biosynthetic process 0.000003277 Highly Informative Direct
Biological Process (BP) response to peptide hormone stimulus 0.0000000000328 Highly Informative Direct
Biological Process (BP) protein targeting to nucleus 0.000000000008767 Highly Informative Direct
Biological Process (BP) mitotic cell cycle phase transition 0.00003272 Highly Informative Direct
Biological Process (BP) cell fate commitment 0.000000000000007347 Highly Informative Direct
Biological Process (BP) negative regulation of cell differentiation 0 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-dependent 0 Highly Informative Direct
Biological Process (BP) development of primary female sexual characteristics 0.0000003398 Highly Informative Direct
Biological Process (BP) regulation of smooth muscle cell proliferation 0.00001474 Highly Informative Direct
Biological Process (BP) stem cell development 0.000000000001586 Highly Informative Direct
Biological Process (BP) negative regulation of secretion 0.0002982 Highly Informative Direct
Biological Process (BP) regulation of striated muscle cell differentiation 0.0000001232 Highly Informative Direct
Biological Process (BP) nuclear import 0.00000000017 Highly Informative Direct
Biological Process (BP) response to calcium ion 0.00002542 Highly Informative Direct
Biological Process (BP) mesenchyme development 0 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0.0004642 Highly Informative Direct
Biological Process (BP) cellular response to metal ion 0.000006743 Highly Informative Direct
Biological Process (BP) cellular response to radiation 0.000000002685 Highly Informative Direct
Biological Process (BP) renal system development 0.000004014 Highly Informative Direct
Biological Process (BP) stem cell proliferation 0.00006357 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.000005127 Highly Informative Direct
Biological Process (BP) intrinsic apoptotic signaling pathway 0.00000325 Highly Informative Direct
Biological Process (BP) cell-type specific apoptotic process 0.00000000001255 Highly Informative Direct
Biological Process (BP) cellular response to peptide 0.00001442 Highly Informative Direct
Biological Process (BP) regulation of organ morphogenesis 0.0003278 Highly Informative Direct
Biological Process (BP) regulation of G1/S transition of mitotic cell cycle 0.0000000001492 Highly Informative Direct
Biological Process (BP) regulation of reactive oxygen species metabolic process 0.01436 Highly Informative Inherited
Biological Process (BP) regulation of synaptic transmission 1 Highly Informative Inherited
Biological Process (BP) regulation of neural precursor cell proliferation 0.505 Highly Informative Inherited
Biological Process (BP) negative regulation of cellular component movement 0.01312 Highly Informative Inherited
Biological Process (BP) negative regulation of locomotion 0.01105 Highly Informative Inherited
Biological Process (BP) negative regulation of mitotic cell cycle phase transition 0.01323 Highly Informative Inherited
Biological Process (BP) regulation of intrinsic apoptotic signaling pathway 0.478 Highly Informative Inherited
Biological Process (BP) positive regulation of apoptotic signaling pathway 0.001149 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 0.09049 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.009352 Highly Informative Inherited
Biological Process (BP) ear development 0.05329 Highly Informative Inherited
Biological Process (BP) positive regulation of cell cycle process 0.7081 Highly Informative Inherited
Biological Process (BP) regulation of calcium-mediated signaling 0.02498 Highly Informative Inherited
Biological Process (BP) positive regulation of programmed cell death 1 Highly Informative Inherited
Biological Process (BP) artery morphogenesis 0.007449 Highly Informative Inherited
Biological Process (BP) cardiac muscle tissue development 0.5535 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 1 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 1 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 1 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.002046 Highly Informative Inherited
Biological Process (BP) glial cell differentiation 0.625 Highly Informative Inherited
Biological Process (BP) cell cycle phase 0.00184 Highly Informative Inherited
Biological Process (BP) sensory perception 0.001432 Highly Informative Inherited
Biological Process (BP) positive regulation of response to external stimulus 0.002198 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 0.0019 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 0.7994 Highly Informative Inherited
Biological Process (BP) positive regulation of cell activation 0.3387 Highly Informative Inherited
Biological Process (BP) positive regulation of lymphocyte mediated immunity 0.6887 Highly Informative Inherited
Biological Process (BP) negative regulation of carbohydrate metabolic process 0.00718 Highly Informative Inherited
Biological Process (BP) regulation of cell size 0.01409 Highly Informative Inherited
Biological Process (BP) regulation of myeloid cell differentiation 0.001687 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 0.04112 Highly Informative Inherited
Biological Process (BP) alpha-beta T cell activation 0.4321 Highly Informative Inherited
Biological Process (BP) DNA damage checkpoint 0.09758 Highly Informative Inherited
Biological Process (BP) regulation of neuron apoptotic process 0.8855 Highly Informative Inherited
Biological Process (BP) negative regulation of protein modification process 0.806 Highly Informative Inherited
Biological Process (BP) negative regulation of phosphorylation 0.2042 Highly Informative Inherited
Biological Process (BP) regulation of MAP kinase activity 0.01542 Highly Informative Inherited
Biological Process (BP) myeloid leukocyte activation 0.4763 Highly Informative Inherited
Biological Process (BP) cellular hormone metabolic process 0.01489 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.6845 Highly Informative Inherited
Biological Process (BP) hormone-mediated signaling pathway 0.2886 Highly Informative Inherited
Biological Process (BP) immune response-regulating cell surface receptor signaling pathway 1 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.1631 Highly Informative Inherited
Biological Process (BP) regulation of innate immune response 0.1528 Highly Informative Inherited
Biological Process (BP) positive regulation of leukocyte proliferation 0.5871 Highly Informative Inherited
Biological Process (BP) response to lipopolysaccharide 0.01474 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.04309 Highly Informative Inherited
Biological Process (BP) epidermal cell differentiation 0.8729 Highly Informative Inherited
Biological Process (BP) regulation of cell adhesion 0.01574 Highly Informative Inherited
Biological Process (BP) regulation of response to nutrient levels 1 Highly Informative Inherited
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.7055 Highly Informative Inherited
Biological Process (BP) positive regulation of epithelial cell proliferation 0.8516 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.02425 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 1 Highly Informative Inherited
Biological Process (BP) cell division 0.4873 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 0.3229 Highly Informative Inherited
Biological Process (BP) negative regulation of cell cycle 0.003304 Highly Informative Inherited
Biological Process (BP) heart morphogenesis 0.007852 Highly Informative Inherited
Biological Process (BP) regulation of humoral immune response 0.02335 Highly Informative Inherited
Biological Process (BP) regulation of multi-organism process 1 Highly Informative Inherited
Biological Process (BP) immune response-activating signal transduction 0.4163 Highly Informative Inherited
Biological Process (BP) T cell differentiation 0.006268 Highly Informative Inherited
Biological Process (BP) B cell activation 0.8667 Highly Informative Inherited
Biological Process (BP) leukocyte proliferation 0.3092 Highly Informative Inherited
Biological Process (BP) leukocyte activation involved in immune response 0.006538 Highly Informative Inherited
Biological Process (BP) connective tissue development 0.5496 Highly Informative Inherited
Biological Process (BP) ossification 0.312 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 1 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 0.7752 Highly Informative Inherited
Biological Process (BP) gonad development 0.4366 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) nucleic acid binding 0 Moderately Informative Direct
Molecular Function (MF) cation binding 0.0001452 Moderately Informative Direct
Molecular Function (MF) anion binding 0.004624 Moderately Informative Inherited
Molecular Function (MF) enzyme regulator activity 0.4645 Moderately Informative Inherited
Molecular Function (MF) nucleotide binding 0.0000174 Informative Direct
Molecular Function (MF) nucleic acid binding transcription factor activity 0 Informative Direct
Molecular Function (MF) DNA binding 0 Informative Direct
Molecular Function (MF) chromatin binding 0 Informative Direct
Molecular Function (MF) purine ribonucleoside binding 0.00000005014 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.00000001977 Informative Direct
Molecular Function (MF) protein dimerization activity 0.00003405 Informative Direct
Molecular Function (MF) enzyme binding 0.03183 Informative Inherited
Molecular Function (MF) transcription factor binding transcription factor activity 0.00000007713 Highly Informative Direct
Molecular Function (MF) copper ion binding 0.0000000000005586 Highly Informative Direct
Molecular Function (MF) ATP binding 0.00000000001757 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0 Highly Informative Direct
Molecular Function (MF) protein phosphatase binding 0.000002457 Highly Informative Direct
Molecular Function (MF) kinase binding 0.03454 Highly Informative Inherited
Molecular Function (MF) sequence-specific DNA binding transcription factor activity 1 Highly Informative Inherited
Molecular Function (MF) transcription regulatory region DNA binding 1 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) protein complex 0.00001819 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.4776 Least Informative Inherited
Cellular Component (CC) cytosol 0.00000000000001758 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 0 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.02259 Moderately Informative Inherited
Cellular Component (CC) extracellular region part 1 Moderately Informative Inherited
Cellular Component (CC) chromosome 0.0006502 Informative Direct
Cellular Component (CC) nucleoplasm part 0.000001612 Informative Direct
Cellular Component (CC) extracellular matrix 0.1823 Informative Inherited
Cellular Component (CC) proteinaceous extracellular matrix 0.02036 Highly Informative Inherited
Cellular Component (CC) extracellular matrix part 0.007142 Highly Informative Inherited

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.086Least InformativeInherited
Disease Ontology (DO)hematologic cancer0.001548Moderately InformativeInherited
Disease Ontology (DO)benign neoplasm0.02477Moderately InformativeInherited
Disease Ontology (DO)mouth disease0.04531Moderately InformativeInherited
Disease Ontology (DO)bacterial infectious disease0.1197Moderately InformativeInherited
Disease Ontology (DO)inflammatory bowel disease0.000003399InformativeDirect
Disease Ontology (DO)connective tissue cancer0.00009319InformativeDirect
Disease Ontology (DO)laryngeal carcinoma0.0005765InformativeDirect
Disease Ontology (DO)physical disorder0.001148InformativeInherited
Disease Ontology (DO)lymphoma0.007693InformativeInherited
Disease Ontology (DO)esophageal disease0.00826InformativeInherited
Disease Ontology (DO)cell type benign neoplasm0.01139InformativeInherited
Disease Ontology (DO)gastrointestinal system cancer0.04766InformativeInherited
Disease Ontology (DO)viral infectious disease0.2707InformativeInherited
Disease Ontology (DO)breast carcinoma0.2895InformativeInherited
Disease Ontology (DO)colitis0.0000001127Highly InformativeDirect
Disease Ontology (DO)Burkitt lymphoma0.00003794Highly InformativeDirect
Disease Ontology (DO)mumps0.00008588Highly InformativeDirect
Disease Ontology (DO)chronic leukemia0.0004145Highly InformativeDirect
Disease Ontology (DO)progressive multifocal leukoencephalopathy0.0005087Highly InformativeDirect
Disease Ontology (DO)pertussis0.0005363Highly InformativeDirect
Disease Ontology (DO)hemangioma0.0006001Highly InformativeDirect
Disease Ontology (DO)stomach disease0.006627Highly InformativeInherited
Disease Ontology (DO)colorectal cancer0.009047Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of head and neck0.1204Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.777Least InformativeInherited
Phenotypic Abnormality (PA)Aplasia/hypoplasia involving the skeleton0.003561Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the hand0.02015Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the mouth0.1875Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the oral cavity0.01504InformativeInherited
Phenotypic Abnormality (PA)Aplasia/hypoplasia involving bones of the hand0.05432InformativeInherited
Phenotypic Abnormality (PA)Absent hand0.0001916Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the humerus0.0007952Highly InformativeDirect
Phenotypic Abnormality (PA)Oral cleft0.00758Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the palate0.0422Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging0.000002766Least InformativeDirect
Mammalian Phenotype (MP)growth/size/body phenotype0.00003837Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0.0001237Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0.00024Least InformativeDirect
Mammalian Phenotype (MP)hematopoietic system phenotype0.001328Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.004208Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.03027Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.05393Least InformativeInherited
Mammalian Phenotype (MP)digestive/alimentary phenotype0.000000009769Moderately InformativeDirect
Mammalian Phenotype (MP)respiratory system phenotype0.00000007724Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal skeleton morphology0.0000002634Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal leukopoiesis0.0000009834Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal gland morphology0.000001843Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal blood cell physiology0.000004424Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.000005544Moderately InformativeDirect
Mammalian Phenotype (MP)integument phenotype0.000008795Moderately InformativeDirect
Mammalian Phenotype (MP)muscle phenotype0.0004761Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal inflammatory response0.0007901Moderately InformativeDirect
Mammalian Phenotype (MP)liver/biliary system phenotype0.001458Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune cell physiology0.00312Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.003447Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell-mediated immunity0.003523Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal adaptive immunity0.004551Moderately InformativeInherited
Mammalian Phenotype (MP)tumorigenesis0.006656Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.007844Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.02503Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.02922Moderately InformativeInherited
Mammalian Phenotype (MP)preweaning lethality0.03198Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.08176Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.09677Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.7302Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal T cell morphology0.000000000506InformativeDirect
Mammalian Phenotype (MP)abnormal interleukin level0.0000000166InformativeDirect
Mammalian Phenotype (MP)increased susceptibility to infection0.000001549InformativeDirect
Mammalian Phenotype (MP)abnormal thymus morphology0.000002018InformativeDirect
Mammalian Phenotype (MP)abnormal fluid regulation0.0001843InformativeDirect
Mammalian Phenotype (MP)hemorrhage0.0002928InformativeDirect
Mammalian Phenotype (MP)abnormal cranium morphology0.0003561InformativeDirect
Mammalian Phenotype (MP)abnormal cell differentiation0.0006922InformativeDirect
Mammalian Phenotype (MP)abnormal hepatobiliary system physiology0.003238InformativeInherited
Mammalian Phenotype (MP)abnormal cartilage morphology0.005658InformativeInherited
Mammalian Phenotype (MP)abnormal antigen presentation0.01329InformativeInherited
Mammalian Phenotype (MP)abnormal lymph node morphology0.02206InformativeInherited
Mammalian Phenotype (MP)abnormal mammary gland morphology0.02351InformativeInherited
Mammalian Phenotype (MP)abnormal circulating cytokine level0.02994InformativeInherited
Mammalian Phenotype (MP)abnormal epidermal layer morphology0.04176InformativeInherited
Mammalian Phenotype (MP)abnormal bone marrow cell morphology/development0.07731InformativeInherited
Mammalian Phenotype (MP)abnormal interferon level0.07797InformativeInherited
Mammalian Phenotype (MP)lethality during fetal growth through weaning0.08024InformativeInherited
Mammalian Phenotype (MP)abnormal B cell physiology0.09279InformativeInherited
Mammalian Phenotype (MP)abnormal appendicular skeleton morphology0.1714InformativeInherited
Mammalian Phenotype (MP)abnormal facial morphology0.1815InformativeInherited
Mammalian Phenotype (MP)abnormal thoracic cage morphology0.1955InformativeInherited
Mammalian Phenotype (MP)increased hemolymphoid system tumor incidence0.2017InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation0.288InformativeInherited
Mammalian Phenotype (MP)abnormal stomach morphology0.296InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial development0.4431InformativeInherited
Mammalian Phenotype (MP)abnormal induced cell death0.4846InformativeInherited
Mammalian Phenotype (MP)abnormal voluntary movement0.5035InformativeInherited
Mammalian Phenotype (MP)abnormal vertebrae morphology0.5853InformativeInherited
Mammalian Phenotype (MP)embryonic lethality0.7786InformativeInherited
Mammalian Phenotype (MP)abnormal Peyer's patch morphology0.8854InformativeInherited
Mammalian Phenotype (MP)abnormal CD4-positive, alpha beta T cell morphology0.00000008146Highly InformativeDirect
Mammalian Phenotype (MP)decreased B cell proliferation0.00001087Highly InformativeDirect
Mammalian Phenotype (MP)complete lethality throughout fetal growth and development0.00004385Highly InformativeDirect
Mammalian Phenotype (MP)respiratory system inflammation0.00004802Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mammary gland development0.00005902Highly InformativeDirect
Mammalian Phenotype (MP)abnormal secondary palate development0.0000746Highly InformativeDirect
Mammalian Phenotype (MP)abnormal intervertebral disk morphology0.0001121Highly InformativeDirect
Mammalian Phenotype (MP)decreased dendritic cell number0.0001164Highly InformativeDirect
Mammalian Phenotype (MP)impaired adaptive thermogenesis0.0001772Highly InformativeDirect
Mammalian Phenotype (MP)abnormal stomach epithelium morphology0.0001968Highly InformativeDirect
Mammalian Phenotype (MP)abnormal thymus medulla morphology0.0002174Highly InformativeDirect
Mammalian Phenotype (MP)cleft palate0.0002428Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cervical atlas morphology0.0002644Highly InformativeDirect
Mammalian Phenotype (MP)no abnormal phenotype detected0.0003744Highly InformativeDirect
Mammalian Phenotype (MP)abnormal level of surface class II molecules0.0003878Highly InformativeDirect
Mammalian Phenotype (MP)impaired natural killer cell mediated cytotoxicity0.0004101Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating insulin-like growth factor I level0.0005593Highly InformativeDirect
Mammalian Phenotype (MP)abnormal granulocyte number0.0005942Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mammary gland alveolus morphology0.0006544Highly InformativeDirect
Mammalian Phenotype (MP)extramedullary hematopoiesis0.0006852Highly InformativeDirect
Mammalian Phenotype (MP)abnormal spinal cord morphology0.004963Highly InformativeInherited
Mammalian Phenotype (MP)increased leukemia incidence0.005483Highly InformativeInherited
Mammalian Phenotype (MP)abnormal head movements0.01237Highly InformativeInherited
Mammalian Phenotype (MP)abnormal clavicle morphology0.02046Highly InformativeInherited
Mammalian Phenotype (MP)embryonic lethality during organogenesis0.03771Highly InformativeInherited
Mammalian Phenotype (MP)decreased sensitivity to induced cell death0.0655Highly InformativeInherited
Mammalian Phenotype (MP)abnormal Peyer's patch size0.1115Highly InformativeInherited
Mammalian Phenotype (MP)abnormal epidermis stratum spinosum morphology0.1502Highly InformativeInherited
Mammalian Phenotype (MP)abnormal peripheral lymph node morphology0.2234Highly InformativeInherited
Mammalian Phenotype (MP)abnormal neurocranium morphology0.3816Highly InformativeInherited
Mammalian Phenotype (MP)abnormal sternum morphology0.8916Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.791Least InformativeInherited
Worm Phenotype (WP)alimentary system morphology variant0.0007835Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased cell number0.0007944Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)anatomical group0.01153Least InformativeInherited
Fly Anatomy (FA)cell0.01886Least InformativeInherited
Fly Anatomy (FA)larva0.04724Least InformativeInherited
Fly Anatomy (FA)organ system0.1033Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)late embryo0.2289Moderately InformativeInherited
Fly Anatomy (FA)mechanosensory sensory organ0.0008328InformativeDirect
Fly Anatomy (FA)circulatory system0.00124InformativeInherited
Fly Anatomy (FA)head mesoderm derived embryonic hemocyte0.0001155Highly InformativeDirect
Fly Anatomy (FA)embryonic/larval circulatory system0.0003326Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)portion of tissue0.1371Least InformativeInherited
Zebrafish Anatomy (ZA)embryonic structure0.00007783Moderately InformativeDirect
Zebrafish Anatomy (ZA)paraxial mesoderm0.00001685InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.09488Least InformativeInherited
Xenopus ANatomical entity (XAN)portion of tissue0.4699Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.7436Least InformativeInherited
Xenopus ANatomical entity (XAN)viscus0.8745Least InformativeInherited
Xenopus ANatomical entity (XAN)cell1Least InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.002102Moderately InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.02008Moderately InformativeInherited
Xenopus ANatomical entity (XAN)surface structure0.1006Moderately InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.1852Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.7644Moderately InformativeInherited
Xenopus ANatomical entity (XAN)mesenchyme0.000004012InformativeDirect
Xenopus ANatomical entity (XAN)notochord0.0000108InformativeDirect
Xenopus ANatomical entity (XAN)anatomical direction0.0000232InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0.0004584InformativeDirect
Xenopus ANatomical entity (XAN)neural plate0.000846InformativeDirect
Xenopus ANatomical entity (XAN)pharyngeal region0.001008InformativeInherited
Xenopus ANatomical entity (XAN)vestibuloauditory system0.001617InformativeInherited
Xenopus ANatomical entity (XAN)primordium0.003271InformativeInherited
Xenopus ANatomical entity (XAN)heart0.3549InformativeInherited
Xenopus ANatomical entity (XAN)involuted ventral mesoderm0.0000001855Highly InformativeDirect
Xenopus ANatomical entity (XAN)fused heart primordium0.000003748Highly InformativeDirect
Xenopus ANatomical entity (XAN)appendage0.0000119Highly InformativeDirect
Xenopus ANatomical entity (XAN)limb bud0.00004984Highly InformativeDirect
Xenopus ANatomical entity (XAN)involuted dorsal mesoderm0.00009881Highly InformativeDirect
Xenopus ANatomical entity (XAN)marginal zone0.6686Highly InformativeInherited
Xenopus DEvelopment stage (XDE)embryonic stage0.0006934Least InformativeDirect

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis0Moderately InformativeDirect
Biological processTranscription regulation0Moderately InformativeDirect
Biological processCell cycle0.00000000000349Moderately InformativeDirect
Biological processBiological rhythms0.000000004612InformativeDirect
Biological processNotch signaling pathway0Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentEndoplasmic reticulum0.000000002194Moderately InformativeDirect
Coding sequence diversityAlternative promoter usage0.0001526Moderately InformativeDirect
DiseaseTumor suppressor0Moderately InformativeDirect
DomainCoiled coil0.00006461Moderately InformativeDirect
DomainSH2 domain0InformativeDirect
DomainANK repeat0.0000001135InformativeDirect
Molecular functionDNA-binding0Least InformativeDirect
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationRepressor0.00000000000003924Moderately InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationAcetylation0.0000000009817Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationIsopeptide bond0Moderately InformativeDirect
Post-translational modificationMethylation0.000001598Moderately InformativeDirect
Post-translational modificationS-nitrosylation0.00001147InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR008967 SSF49417 Protein matches
Abstract

This domain is found in a number of transcription factors, including p53, NFATC, TonEBP, STAT-1, and NFkappaB, where it is responsible for DNA-binding. These transcription factors play diverse roles in the regulation of cellular functions: the p53 tumour suppressor upregulates the expression of genes involved in cell cycle arrest and apoptosis [PubMed12826037]; NFATC regulates the production of effector proteins involved in coordinating the immune response [PubMed8990122]; TonEBP regulates gene expression induced by osmotic stress and helps regulate intracellular volume during cell growth [PubMed12729611]; STAT-1 plays an important role in B lymphocyte growth and function [PubMed12855573]; and NFkappaB is involved in the inflammatory response [PubMed12421671]. The DNA-binding domain acts to clamp, or in the case of TonEBP, encircle the DNA target in order to stabilize the protein-DNA complex [PubMed11780147]. Protein interactions may also serve to stabilize the protein-DNA complex, for example in the STAT-1 dimer the SH2 (Src homology 2) domain in each monomer is coupled to the DNA-binding domain to increase stability [PubMed9630226]. The DNA-binding domain consists of a beta-sandwich formed of 9 strands in 2 sheets with a Greek-key topology. This structure is found in many transcription factors, often within the DNA-binding domain.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 19 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a p53-like transcription factors domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 19 hidden Markov models representing the p53-like transcription factors superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]