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p53-like transcription factors superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Common fold of diphtheria toxin/transcription factors/cytochrome f [ 49379] (10)
Superfamily:   p53-like transcription factors [ 49417] (7)
Families:   p53 DNA-binding domain-like [ 81314] (2)
  Rel/Dorsal transcription factors, DNA-binding domain [ 81315] (6)
  T-box [ 81316] (2)
  STAT DNA-binding domain [ 81317] (3)
  RUNT domain [ 81318]
  DNA-binding domain from NDT80 [ 81992]
  DNA-binding protein LAG-1 (CSL) [ 110080]


Superfamily statistics
Genomes (367) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 6,320 19,251 53
Proteins 6,210 18,948 53


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.104Least InformativeInherited
Disease Ontology (DO)hematologic cancer0.001439Moderately InformativeInherited
Disease Ontology (DO)disease by infectious agent0.004818Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.01039Moderately InformativeInherited
Disease Ontology (DO)benign neoplasm0.02455Moderately InformativeInherited
Disease Ontology (DO)head and neck carcinoma0.0000002781InformativeDirect
Disease Ontology (DO)inflammatory bowel disease0.000002648InformativeDirect
Disease Ontology (DO)connective tissue cancer0.00009353InformativeDirect
Disease Ontology (DO)physical disorder0.00119InformativeInherited
Disease Ontology (DO)lymphoma0.00729InformativeInherited
Disease Ontology (DO)breast cancer0.008682InformativeInherited
Disease Ontology (DO)cell type benign neoplasm0.01089InformativeInherited
Disease Ontology (DO)respiratory system cancer0.1016InformativeInherited
Disease Ontology (DO)viral infectious disease0.2674InformativeInherited
Disease Ontology (DO)colitis0.00000008759Highly InformativeDirect
Disease Ontology (DO)Burkitt lymphoma0.0000272Highly InformativeDirect
Disease Ontology (DO)mumps0.00006602Highly InformativeDirect
Disease Ontology (DO)Barrett's esophagus0.00007288Highly InformativeDirect
Disease Ontology (DO)gastritis0.00025Highly InformativeDirect
Disease Ontology (DO)chronic leukemia0.0004023Highly InformativeDirect
Disease Ontology (DO)pertussis0.0004151Highly InformativeDirect
Disease Ontology (DO)progressive multifocal leukoencephalopathy0.0005143Highly InformativeDirect
Disease Ontology (DO)laryngeal carcinoma0.0005392Highly InformativeDirect
Disease Ontology (DO)hemangioma0.0005584Highly InformativeDirect
Disease Ontology (DO)salivary gland adenoid cystic carcinoma0.0007384Highly InformativeDirect
Disease Ontology (DO)large intestine cancer0.007591Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the skeletal system0.1233Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the head0.2464Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.3648Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limb bone morphology0.08336Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper limb0.1619Moderately InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.18Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.2044Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the thorax0.2896Moderately InformativeInherited
Phenotypic Abnormality (PA)Aplasia/hypoplasia of the extremities0.02663InformativeInherited
Phenotypic Abnormality (PA)Lymphoma0.0004879Highly InformativeDirect
Phenotypic Abnormality (PA)Aplasia/Hypoplasia involving bones of the thorax0.01189Highly InformativeInherited
Phenotypic Abnormality (PA)Aplasia/hypoplasia involving bones of the hand0.203Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)growth/size/body region phenotype0.000001622Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0.000002056Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0.0002034Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0.000342Least InformativeDirect
Mammalian Phenotype (MP)hematopoietic system phenotype0.006122Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.007579Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.02698Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.1981Least InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.000000009941Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal leukocyte physiology0.0000005025Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal skeleton morphology0.000000831Moderately InformativeDirect
Mammalian Phenotype (MP)integument phenotype0.000001217Moderately InformativeDirect
Mammalian Phenotype (MP)embryo phenotype0.000001873Moderately InformativeDirect
Mammalian Phenotype (MP)respiratory system phenotype0.000005447Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal craniofacial morphology0.000009462Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal gland morphology0.000009626Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.00002869Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal blood cell morphology0.00008702Moderately InformativeDirect
Mammalian Phenotype (MP)liver/biliary system phenotype0.0008508Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal inflammatory response0.001447Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.003601Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.0059Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.01523Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.02008Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.03062Moderately InformativeInherited
Mammalian Phenotype (MP)neoplasm0.03177Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.03402Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal myeloid cell morphology0.04821Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.05445Moderately InformativeInherited
Mammalian Phenotype (MP)lethality during fetal growth through weaning0.05842Moderately InformativeInherited
Mammalian Phenotype (MP)prenatal lethality0.08299Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.1005Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.1332Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.4832Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.7241Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin level0.00000001078InformativeDirect
Mammalian Phenotype (MP)increased susceptibility to infection0.0000003092InformativeDirect
Mammalian Phenotype (MP)abnormal liver physiology0.000003215InformativeDirect
Mammalian Phenotype (MP)abnormal thymus morphology0.00001351InformativeDirect
Mammalian Phenotype (MP)abnormal coat appearance0.00001994InformativeDirect
Mammalian Phenotype (MP)abnormal T cell differentiation0.00003044InformativeDirect
Mammalian Phenotype (MP)abnormal fluid regulation0.00004723InformativeDirect
Mammalian Phenotype (MP)normal phenotype0.00006785InformativeDirect
Mammalian Phenotype (MP)abnormal B cell proliferation0.0001197InformativeDirect
Mammalian Phenotype (MP)hemorrhage0.000136InformativeDirect
Mammalian Phenotype (MP)altered tumor pathology0.0003108InformativeDirect
Mammalian Phenotype (MP)increased leukocyte cell number0.0004409InformativeDirect
Mammalian Phenotype (MP)abnormal cartilage morphology0.002052InformativeInherited
Mammalian Phenotype (MP)abnormal humoral immune response0.003874InformativeInherited
Mammalian Phenotype (MP)abnormal adaptive thermogenesis0.004062InformativeInherited
Mammalian Phenotype (MP)abnormal spinal cord morphology0.008851InformativeInherited
Mammalian Phenotype (MP)abnormal epidermal layer morphology0.0102InformativeInherited
Mammalian Phenotype (MP)abnormal circulating cytokine level0.01193InformativeInherited
Mammalian Phenotype (MP)abnormal gland physiology0.0227InformativeInherited
Mammalian Phenotype (MP)abnormal B lymphocyte antigen presentation0.02866InformativeInherited
Mammalian Phenotype (MP)abnormal lymph node morphology0.04134InformativeInherited
Mammalian Phenotype (MP)abnormal head morphology0.04169InformativeInherited
Mammalian Phenotype (MP)abnormal interferon level0.07153InformativeInherited
Mammalian Phenotype (MP)abnormal mammary gland morphology0.07608InformativeInherited
Mammalian Phenotype (MP)abnormal appendicular skeleton morphology0.08006InformativeInherited
Mammalian Phenotype (MP)abnormal thoracic cage morphology0.2403InformativeInherited
Mammalian Phenotype (MP)abnormal natural killer cell mediated cytotoxicity0.2424InformativeInherited
Mammalian Phenotype (MP)abnormal stomach morphology0.3271InformativeInherited
Mammalian Phenotype (MP)increased hemolymphoid system tumor incidence0.3509InformativeInherited
Mammalian Phenotype (MP)increased carcinoma incidence0.3809InformativeInherited
Mammalian Phenotype (MP)abnormal voluntary movement0.4845InformativeInherited
Mammalian Phenotype (MP)abnormal erythroid lineage cell morphology0.5392InformativeInherited
Mammalian Phenotype (MP)abnormal vertebrae morphology0.6966InformativeInherited
Mammalian Phenotype (MP)abnormal Peyer's patch morphology0.8937InformativeInherited
Mammalian Phenotype (MP)decreased B cell proliferation0.000006251Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mammary gland epithelium physiology0.000009151Highly InformativeDirect
Mammalian Phenotype (MP)respiratory system inflammation0.000009679Highly InformativeDirect
Mammalian Phenotype (MP)lethality throughout fetal growth and development, complete penetrance0.00002658Highly InformativeDirect
Mammalian Phenotype (MP)abnormal secondary palate development0.00006098Highly InformativeDirect
Mammalian Phenotype (MP)abnormal intervertebral disk morphology0.0001114Highly InformativeDirect
Mammalian Phenotype (MP)impaired adaptive thermogenesis0.0001291Highly InformativeDirect
Mammalian Phenotype (MP)decreased dendritic cell number0.0001312Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cervical atlas morphology0.0001412Highly InformativeDirect
Mammalian Phenotype (MP)abnormal stomach epithelium morphology0.0001707Highly InformativeDirect
Mammalian Phenotype (MP)cleft palate0.0002129Highly InformativeDirect
Mammalian Phenotype (MP)abnormal level of surface class II molecules0.000275Highly InformativeDirect
Mammalian Phenotype (MP)abnormal thymus medulla morphology0.0003092Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart development0.000321Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating insulin-like growth factor I level0.0005459Highly InformativeDirect
Mammalian Phenotype (MP)increased adenocarcinoma incidence0.000623Highly InformativeDirect
Mammalian Phenotype (MP)abnormal granulocyte number0.0006581Highly InformativeDirect
Mammalian Phenotype (MP)abnormal vertebral arch morphology0.0008304Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mammary gland alveolus morphology0.0008647Highly InformativeDirect
Mammalian Phenotype (MP)abnormal spinal cord white matter morphology0.008995Highly InformativeInherited
Mammalian Phenotype (MP)abnormal IgG2a level0.01025Highly InformativeInherited
Mammalian Phenotype (MP)abnormal head movements0.01288Highly InformativeInherited
Mammalian Phenotype (MP)increased leukemia incidence0.01365Highly InformativeInherited
Mammalian Phenotype (MP)abnormal bone marrow cell morphology/development0.01872Highly InformativeInherited
Mammalian Phenotype (MP)embryonic lethality during organogenesis0.06019Highly InformativeInherited
Mammalian Phenotype (MP)abnormal Peyer's patch size0.1245Highly InformativeInherited
Mammalian Phenotype (MP)abnormal peripheral lymph node morphology0.1484Highly InformativeInherited
Mammalian Phenotype (MP)abnormal epidermis stratum spinosum morphology0.219Highly InformativeInherited
Mammalian Phenotype (MP)abnormal neurocranium morphology0.264Highly InformativeInherited
Mammalian Phenotype (MP)increased IgG level0.3557Highly InformativeInherited
Mammalian Phenotype (MP)abnormal sternum morphology0.8445Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organ system morphology variant0.01799Least InformativeInherited
Worm Phenotype (WP)cell development variant0.04318Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.05521Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.2043Least InformativeInherited
Worm Phenotype (WP)level of transgene expression variant0.0007807Moderately InformativeDirect
Worm Phenotype (WP)cell division variant0.04358Moderately InformativeInherited
Worm Phenotype (WP)pattern of transgene expression variant1Moderately InformativeInherited
Worm Phenotype (WP)lineage variant0.0004764Highly InformativeDirect
Worm Phenotype (WP)alimentary system morphology variant0.0005839Highly InformativeDirect
Worm Phenotype (WP)ectopic expression transgene0.0006114Highly InformativeDirect
Worm Phenotype (WP)gene expression level reduced0.0007356Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)cell number defective0.01613InformativeInherited
Fly Phenotype (FP)increased cell number0.0004972Highly InformativeDirect
Fly Phenotype (FP)cell size defective0.0224Highly InformativeInherited

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)adult0.002394Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.01034Least InformativeInherited
Fly Anatomy (FA)anatomical group0.02595Least InformativeInherited
Fly Anatomy (FA)somatic cell0.03898Least InformativeInherited
Fly Anatomy (FA)larva0.1041Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)sense organ0.01238Moderately InformativeInherited
Fly Anatomy (FA)adult segment0.02446Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.03129Moderately InformativeInherited
Fly Anatomy (FA)adult thorax0.03443Moderately InformativeInherited
Fly Anatomy (FA)late embryo0.05993Moderately InformativeInherited
Fly Anatomy (FA)thoracic segment0.1118Moderately InformativeInherited
Fly Anatomy (FA)tagmatic subdivision of integument0.5405Moderately InformativeInherited
Fly Anatomy (FA)mechanosensory system0.0002388InformativeDirect
Fly Anatomy (FA)embryonic/larval circulatory system0.0002439InformativeDirect
Fly Anatomy (FA)anatomical space0.002005InformativeInherited
Fly Anatomy (FA)head mesoderm derived embryonic hemocyte0.0001815Highly InformativeDirect
Fly Anatomy (FA)mesothoracic tergum0.0004543Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)portion of tissue0.06657Moderately InformativeInherited
Zebrafish Anatomy (ZA)mesenchyme0.00004094Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)tissue0.1119Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.2261Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.564Least InformativeInherited
Xenopus ANatomical entity (XAN)nervous system0.6321Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.9306Least InformativeInherited
Xenopus ANatomical entity (XAN)trunk1Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.00000119Moderately InformativeDirect
Xenopus ANatomical entity (XAN)sensory system0.0002623Moderately InformativeDirect
Xenopus ANatomical entity (XAN)embryonic structure0.004435Moderately InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.1575Moderately InformativeInherited
Xenopus ANatomical entity (XAN)viscus0.737Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.7642Moderately InformativeInherited
Xenopus ANatomical entity (XAN)mesenchyme0.00000263InformativeDirect
Xenopus ANatomical entity (XAN)pharyngeal region0.000005092InformativeDirect
Xenopus ANatomical entity (XAN)anatomical direction0.0000153InformativeDirect
Xenopus ANatomical entity (XAN)neural plate0.00001768InformativeDirect
Xenopus ANatomical entity (XAN)cardiovascular system0.00003334InformativeDirect
Xenopus ANatomical entity (XAN)cranial placode0.000171InformativeDirect
Xenopus ANatomical entity (XAN)peripheral nervous system0.003068InformativeInherited
Xenopus ANatomical entity (XAN)lateral plate mesoderm0.01449InformativeInherited
Xenopus ANatomical entity (XAN)surface structure0.03696InformativeInherited
Xenopus ANatomical entity (XAN)skeletal system0.1173InformativeInherited
Xenopus ANatomical entity (XAN)connective tissue0.6126InformativeInherited
Xenopus ANatomical entity (XAN)limb0.626InformativeInherited
Xenopus ANatomical entity (XAN)solid compound organ0.8092InformativeInherited
Xenopus ANatomical entity (XAN)neurogenic placode0.000005401Highly InformativeDirect
Xenopus ANatomical entity (XAN)blastema0.0002532Highly InformativeDirect
Xenopus ANatomical entity (XAN)hindlimb0.0002595Highly InformativeDirect
Xenopus ANatomical entity (XAN)neuron0.0006675Highly InformativeDirect
Xenopus ANatomical entity (XAN)primordium0.0007831Highly InformativeDirect
Xenopus ANatomical entity (XAN)cranium0.001177Highly InformativeInherited
Xenopus ANatomical entity (XAN)cranial nerve0.02387Highly InformativeInherited
Xenopus ANatomical entity (XAN)gustatory system0.02514Highly InformativeInherited
Xenopus ANatomical entity (XAN)branchial arch0.2017Highly InformativeInherited
Xenopus ANatomical entity (XAN)marginal zone1Highly InformativeInherited
Xenopus DEvelopment stage (XDE)post-embryonic stage0.7638Least InformativeInherited
Xenopus DEvelopment stage (XDE)premetamorphosis stage0.0004063Highly InformativeDirect

Document: XA annotation of SCOP domains

InterPro annotation
Cross references IPR008967 SSF49417 Protein matches
Abstract

This domain is found in a number of transcription factors, including p53, NFATC, TonEBP, STAT-1, and NFkappaB, where it is responsible for DNA-binding. These transcription factors play diverse roles in the regulation of cellular functions: the p53 tumour suppressor upregulates the expression of genes involved in cell cycle arrest and apoptosis [PubMed12826037]; NFATC regulates the production of effector proteins involved in coordinating the immune response [PubMed8990122]; TonEBP regulates gene expression induced by osmotic stress and helps regulate intracellular volume during cell growth [PubMed12729611]; STAT-1 plays an important role in B lymphocyte growth and function [PubMed12855573]; and NFkappaB is involved in the inflammatory response [PubMed12421671]. The DNA-binding domain acts to clamp, or in the case of TonEBP, encircle the DNA target in order to stabilize the protein-DNA complex [PubMed11780147]. Protein interactions may also serve to stabilize the protein-DNA complex, for example in the STAT-1 dimer the SH2 (Src homology 2) domain in each monomer is coupled to the DNA-binding domain to increase stability [PubMed9630226]. The DNA-binding domain consists of a beta-sandwich formed of 9 strands in 2 sheets with a Greek-key topology. This structure is found in many transcription factors, often within the DNA-binding domain.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 26 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a p53-like transcription factors domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 26 hidden Markov models representing the p53-like transcription factors superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]