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p53-like transcription factors superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Common fold of diphtheria toxin/transcription factors/cytochrome f [ 49379] (10)
Superfamily:   p53-like transcription factors [ 49417] (7)
Families:   p53 DNA-binding domain-like [ 81314] (2)
  Rel/Dorsal transcription factors, DNA-binding domain [ 81315] (6)
  T-box [ 81316] (2)
  STAT DNA-binding domain [ 81317] (3)
  RUNT domain [ 81318]
  DNA-binding domain from NDT80 [ 81992]
  DNA-binding protein LAG-1 (CSL) [ 110080]


Superfamily statistics
Genomes (365) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 6,245 15,624 53
Proteins 6,135 15,360 53


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism cellular process0.072540.001168Least InformativeInherited
Biological Process (BP)biological regulation0.019330Least InformativeInherited
Biological Process (BP)cellular developmental process0.000049080Moderately InformativeDirect
Biological Process (BP)regulation of gene expression0.00022010Moderately InformativeDirect
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.00088840Moderately InformativeDirect
Biological Process (BP)regulation of macromolecule biosynthetic process0.077770Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process0.0014030Moderately InformativeInherited
Biological Process (BP)system development0.67230.7407Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.022310Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.0073720Moderately InformativeInherited
Biological Process (BP)positive regulation of gene expression0.0000024110InformativeDirect
Biological Process (BP)behavior0.000015720InformativeDirect
Biological Process (BP)circulatory system development0.000016230.00000000007561InformativeDirect
Biological Process (BP)positive regulation of nucleobase-containing compound metabolic process0.00002640InformativeDirect
Biological Process (BP)positive regulation of cellular biosynthetic process0.000046860InformativeDirect
Biological Process (BP)positive regulation of macromolecule biosynthetic process0.0053190InformativeInherited
Biological Process (BP)regulation of transcription, DNA-templated0.14840InformativeInherited
Biological Process (BP)regulation of transcription from RNA polymerase II promoter0.000010240.000000008555Highly InformativeDirect
Molecular Function (MF)binding0.082880Least InformativeInherited
Molecular Function (MF)nucleic acid binding0.00029620Moderately InformativeDirect
Molecular Function (MF)transcription factor activity, sequence-specific DNA binding0.0000000000024840InformativeDirect
Molecular Function (MF)DNA binding0.000015720InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.03307 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.001168 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.09963 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.04459 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 0.2194 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular developmental process 0 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.0000000000003986 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.00000327 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.00000001329 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) single organism signaling 0 Moderately Informative Direct
Biological Process (BP) cell communication 0 Moderately Informative Direct
Biological Process (BP) reproduction 0.0000001525 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.0000002246 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.00001665 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.0003064 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.01069 Moderately Informative Inherited
Biological Process (BP) system development 0.7407 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.008135 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.06107 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) nitrogen compound transport 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.01035 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.00355 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.02058 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.0955 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.1192 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.6711 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.003517 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.5789 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.6219 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.1808 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.0315 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.2157 Moderately Informative Inherited
Biological Process (BP) gene expression 0.4379 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.005953 Moderately Informative Inherited
Biological Process (BP) positive regulation of gene expression 0 Informative Direct
Biological Process (BP) behavior 0 Informative Direct
Biological Process (BP) circulatory system development 0.00000000007561 Informative Direct
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 0 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0 Informative Direct
Biological Process (BP) regulation of cell differentiation 0.0000000000004016 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0 Informative Direct
Biological Process (BP) embryo development 0.0000000002341 Informative Direct
Biological Process (BP) regulation of transcription, DNA-templated 0 Informative Direct
Biological Process (BP) response to cytokine 0 Informative Direct
Biological Process (BP) cell death 0 Informative Direct
Biological Process (BP) regulation of cell proliferation 0 Informative Direct
Biological Process (BP) intracellular signal transduction 0.00000000000002124 Informative Direct
Biological Process (BP) tissue development 0.00000000001657 Informative Direct
Biological Process (BP) cell activation 0.000000007326 Informative Direct
Biological Process (BP) regulation of growth 0.000000009448 Informative Direct
Biological Process (BP) transcription, DNA-templated 0.0000000954 Informative Direct
Biological Process (BP) positive regulation of cell death 0.0000002678 Informative Direct
Biological Process (BP) DNA metabolic process 0.0000008965 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.000001193 Informative Direct
Biological Process (BP) immune response 0.00000531 Informative Direct
Biological Process (BP) cellular response to hormone stimulus 0.00002437 Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.00002659 Informative Direct
Biological Process (BP) regulation of proteolysis 0.00003599 Informative Direct
Biological Process (BP) animal organ morphogenesis 0.00004752 Informative Direct
Biological Process (BP) regulation of hydrolase activity 0.0000492 Informative Direct
Biological Process (BP) locomotion 0.000166 Informative Direct
Biological Process (BP) response to nitrogen compound 0.0002927 Informative Direct
Biological Process (BP) lipid localization 0.0003555 Informative Direct
Biological Process (BP) positive regulation of developmental process 0.0006058 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.1415 Informative Inherited
Biological Process (BP) regulation of secretion 0.002278 Informative Inherited
Biological Process (BP) regulation of cellular localization 0.4763 Informative Inherited
Biological Process (BP) regulation of locomotion 1 Informative Inherited
Biological Process (BP) regulation of cellular component movement 1 Informative Inherited
Biological Process (BP) negative regulation of transport 0.2505 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 1 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.05197 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.01043 Informative Inherited
Biological Process (BP) cellular response to lipid 0.7985 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.001568 Informative Inherited
Biological Process (BP) cell development 1 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.3508 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 1 Informative Inherited
Biological Process (BP) regulation of defense response 0.4084 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) mitochondrion organization 0.06432 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.05386 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.005446 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.6339 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.7168 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.05062 Informative Inherited
Biological Process (BP) response to oxidative stress 0.4504 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.02916 Informative Inherited
Biological Process (BP) cellular ketone metabolic process 0.05423 Informative Inherited
Biological Process (BP) sensory organ development 0.3111 Informative Inherited
Biological Process (BP) response to acid chemical 0.553 Informative Inherited
Biological Process (BP) chromosome organization 0.001063 Informative Inherited
Biological Process (BP) single organism reproductive process 0.1707 Informative Inherited
Biological Process (BP) central nervous system development 0.3219 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 0.01447 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.2307 Informative Inherited
Biological Process (BP) movement of cell or subcellular component 0.137 Informative Inherited
Biological Process (BP) regulation of catabolic process 1 Informative Inherited
Biological Process (BP) regulation of nervous system development 1 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.4628 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) response to radiation 0.0449 Informative Inherited
Biological Process (BP) cellular response to DNA damage stimulus 0.203 Informative Inherited
Biological Process (BP) response to extracellular stimulus 0.006957 Informative Inherited
Biological Process (BP) membrane organization 0.2417 Informative Inherited
Biological Process (BP) protein localization to organelle 0.201 Informative Inherited
Biological Process (BP) intracellular protein transport 0.4027 Informative Inherited
Biological Process (BP) single-organism intracellular transport 0.305 Informative Inherited
Biological Process (BP) growth 0.009766 Informative Inherited
Biological Process (BP) system process 0.5327 Informative Inherited
Biological Process (BP) immune effector process 1 Informative Inherited
Biological Process (BP) reproductive system development 1 Informative Inherited
Biological Process (BP) multicellular organism reproduction 1 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.000000008555 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-templated 0 Highly Informative Direct
Biological Process (BP) apoptotic process 0 Highly Informative Direct
Biological Process (BP) regulation of mitochondrion organization 0 Highly Informative Direct
Biological Process (BP) cytokine-mediated signaling pathway 0 Highly Informative Direct
Biological Process (BP) photoperiodism 0.0000000000000109 Highly Informative Direct
Biological Process (BP) cell proliferation 0.0000000000002239 Highly Informative Direct
Biological Process (BP) pattern specification process 0.000000000001199 Highly Informative Direct
Biological Process (BP) response to nutrient levels 0.00000000003039 Highly Informative Direct
Biological Process (BP) response to purine-containing compound 0.00000000003523 Highly Informative Direct
Biological Process (BP) response to organophosphorus 0.0000000003953 Highly Informative Direct
Biological Process (BP) positive regulation of proteolysis 0.0000000004781 Highly Informative Direct
Biological Process (BP) response to peptide hormone 0.0000000005564 Highly Informative Direct
Biological Process (BP) regulation of apoptotic signaling pathway 0.00000000193 Highly Informative Direct
Biological Process (BP) aging 0.00000001914 Highly Informative Direct
Biological Process (BP) negative regulation of growth 0.0000000386 Highly Informative Direct
Biological Process (BP) regulation of circadian rhythm 0.00000004014 Highly Informative Direct
Biological Process (BP) leukocyte differentiation 0.0000001733 Highly Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0.0000001746 Highly Informative Direct
Biological Process (BP) response to hydrogen peroxide 0.0000003815 Highly Informative Direct
Biological Process (BP) lymphocyte activation 0.0000004947 Highly Informative Direct
Biological Process (BP) regulation of smooth muscle cell proliferation 0.0000006763 Highly Informative Direct
Biological Process (BP) innate immune response 0.000001788 Highly Informative Direct
Biological Process (BP) positive regulation of lymphocyte activation 0.000003628 Highly Informative Direct
Biological Process (BP) response to retinoic acid 0.000005303 Highly Informative Direct
Biological Process (BP) kidney development 0.00001017 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular signal transduction 0.00001116 Highly Informative Direct
Biological Process (BP) sex differentiation 0.00001954 Highly Informative Direct
Biological Process (BP) appendage development 0.00005097 Highly Informative Direct
Biological Process (BP) mitochondrial membrane organization 0.00008646 Highly Informative Direct
Biological Process (BP) angiogenesis 0.0001463 Highly Informative Direct
Biological Process (BP) positive regulation of apoptotic process 0.0001643 Highly Informative Direct
Biological Process (BP) wound healing 0.0001672 Highly Informative Direct
Biological Process (BP) cellular response to organonitrogen compound 0.0002256 Highly Informative Direct
Biological Process (BP) maintenance of location 0.0003148 Highly Informative Direct
Biological Process (BP) embryonic organ morphogenesis 0.0003627 Highly Informative Direct
Biological Process (BP) regulation of DNA-templated transcription in response to stress 0.0004633 Highly Informative Direct
Biological Process (BP) protein targeting to nucleus 0.0005295 Highly Informative Direct
Biological Process (BP) regulation of membrane permeability 0.0006308 Highly Informative Direct
Biological Process (BP) calcium-mediated signaling 0.0006663 Highly Informative Direct
Biological Process (BP) multicellular organismal homeostasis 0.0008907 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.4969 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular transport 0.001986 Highly Informative Inherited
Biological Process (BP) negative regulation of secretion by cell 0.002765 Highly Informative Inherited
Biological Process (BP) regulation of vesicle-mediated transport 0.9596 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.04632 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.07318 Highly Informative Inherited
Biological Process (BP) epithelial cell differentiation 0.5711 Highly Informative Inherited
Biological Process (BP) cellular response to abiotic stimulus 0.1409 Highly Informative Inherited
Biological Process (BP) cellular response to acid chemical 0.2824 Highly Informative Inherited
Biological Process (BP) response to endoplasmic reticulum stress 0.03603 Highly Informative Inherited
Biological Process (BP) myeloid cell differentiation 0.01133 Highly Informative Inherited
Biological Process (BP) cellular response to decreased oxygen levels 0.02546 Highly Informative Inherited
Biological Process (BP) response to hypoxia 0.1131 Highly Informative Inherited
Biological Process (BP) regeneration 0.2366 Highly Informative Inherited
Biological Process (BP) gastrulation 0.2425 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.05575 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.2323 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.2018 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 0.006772 Highly Informative Inherited
Biological Process (BP) positive regulation of response to external stimulus 0.2622 Highly Informative Inherited
Biological Process (BP) neuron development 1 Highly Informative Inherited
Biological Process (BP) myeloid cell homeostasis 0.07152 Highly Informative Inherited
Biological Process (BP) inner ear development 0.007958 Highly Informative Inherited
Biological Process (BP) gliogenesis 0.1679 Highly Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 1 Highly Informative Inherited
Biological Process (BP) circadian rhythm 0.3423 Highly Informative Inherited
Biological Process (BP) regulation of neurotransmitter levels 0.08197 Highly Informative Inherited
Biological Process (BP) mitochondrial transport 0.004939 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 0.4245 Highly Informative Inherited
Biological Process (BP) regulation of lymphocyte proliferation 0.02846 Highly Informative Inherited
Biological Process (BP) negative regulation of nervous system development 0.9622 Highly Informative Inherited
Biological Process (BP) negative regulation of cell development 0.9906 Highly Informative Inherited
Biological Process (BP) positive regulation of homeostatic process 0.008189 Highly Informative Inherited
Biological Process (BP) negative regulation of homeostatic process 0.0239 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.8943 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.287 Highly Informative Inherited
Biological Process (BP) muscle structure development 0.003095 Highly Informative Inherited
Biological Process (BP) sensory organ morphogenesis 0.009645 Highly Informative Inherited
Biological Process (BP) positive regulation of cell adhesion 1 Highly Informative Inherited
Biological Process (BP) positive regulation of leukocyte proliferation 0.7956 Highly Informative Inherited
Biological Process (BP) hormone-mediated signaling pathway 0.09558 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.01514 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 0.2175 Highly Informative Inherited
Biological Process (BP) negative regulation of locomotion 0.2485 Highly Informative Inherited
Biological Process (BP) negative regulation of cellular component movement 0.3171 Highly Informative Inherited
Biological Process (BP) regulation of cell growth 0.002354 Highly Informative Inherited
Biological Process (BP) regulation of autophagy 0.0265 Highly Informative Inherited
Biological Process (BP) positive regulation of nervous system development 1 Highly Informative Inherited
Biological Process (BP) positive regulation of cell development 1 Highly Informative Inherited
Biological Process (BP) cellular hormone metabolic process 0.003232 Highly Informative Inherited
Biological Process (BP) neurological system process 1 Highly Informative Inherited
Biological Process (BP) regulation of cysteine-type endopeptidase activity 0.03757 Highly Informative Inherited
Biological Process (BP) protein import 0.002588 Highly Informative Inherited
Biological Process (BP) developmental growth involved in morphogenesis 0.7103 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.9098 Highly Informative Inherited
Biological Process (BP) tube morphogenesis 0.002406 Highly Informative Inherited
Biological Process (BP) regulation of humoral immune response 0.02147 Highly Informative Inherited
Biological Process (BP) regulation of epithelial cell proliferation 0.11 Highly Informative Inherited
Biological Process (BP) ovulation cycle process 0.00231 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) nucleic acid binding 0 Moderately Informative Direct
Molecular Function (MF) metal ion binding 0.0004673 Moderately Informative Direct
Molecular Function (MF) anion binding 0.01509 Moderately Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 0.3044 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 0.8008 Moderately Informative Inherited
Molecular Function (MF) transcription factor activity, sequence-specific DNA binding 0 Informative Direct
Molecular Function (MF) DNA binding 0 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.00000004289 Informative Direct
Molecular Function (MF) purine nucleotide binding 0.0000004609 Informative Direct
Molecular Function (MF) ribonucleotide binding 0.0000006853 Informative Direct
Molecular Function (MF) enzyme binding 0.00001348 Informative Direct
Molecular Function (MF) protein dimerization activity 0.00001671 Informative Direct
Molecular Function (MF) receptor binding 0.1846 Informative Inherited
Molecular Function (MF) transcription factor binding 0 Highly Informative Direct
Molecular Function (MF) copper ion binding 0.0000000000001026 Highly Informative Direct
Molecular Function (MF) ATP binding 0.00000000006334 Highly Informative Direct
Molecular Function (MF) protein phosphatase binding 0.0000003648 Highly Informative Direct
Molecular Function (MF) chromatin binding 0.000001667 Highly Informative Direct
Molecular Function (MF) chaperone binding 0.0005056 Highly Informative Direct
Molecular Function (MF) kinase binding 0.0006907 Highly Informative Direct
Molecular Function (MF) cytokine receptor binding 0.1882 Highly Informative Inherited
Molecular Function (MF) G-protein coupled receptor binding 0.07148 Highly Informative Inherited
Molecular Function (MF) transcription factor activity, transcription factor binding 0.3664 Highly Informative Inherited
Molecular Function (MF) transcription regulatory region DNA binding 1 Highly Informative Inherited
Molecular Function (MF) sequence-specific DNA binding 0.002738 Highly Informative Inherited
Molecular Function (MF) double-stranded DNA binding 0.08832 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0.7449 Least Informative Inherited
Cellular Component (CC) macromolecular complex 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.000001444 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.3118 Moderately Informative Inherited
Cellular Component (CC) chromosome 0.0004927 Informative Direct
Cellular Component (CC) chromatin 0.000002244 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.1032Least InformativeInherited
Disease Ontology (DO)hematologic cancer0.001402Moderately InformativeInherited
Disease Ontology (DO)disease by infectious agent0.004655Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.009973Moderately InformativeInherited
Disease Ontology (DO)benign neoplasm0.02398Moderately InformativeInherited
Disease Ontology (DO)head and neck carcinoma0.0000002491InformativeDirect
Disease Ontology (DO)inflammatory bowel disease0.000002338InformativeDirect
Disease Ontology (DO)connective tissue cancer0.00009124InformativeDirect
Disease Ontology (DO)physical disorder0.001176InformativeInherited
Disease Ontology (DO)kidney cancer0.004115InformativeInherited
Disease Ontology (DO)lymphoma0.007042InformativeInherited
Disease Ontology (DO)cell type benign neoplasm0.01059InformativeInherited
Disease Ontology (DO)respiratory system cancer0.1009InformativeInherited
Disease Ontology (DO)viral infectious disease0.2655InformativeInherited
Disease Ontology (DO)breast carcinoma0.3038InformativeInherited
Disease Ontology (DO)colitis0.00000008128Highly InformativeDirect
Disease Ontology (DO)Burkitt lymphoma0.00002686Highly InformativeDirect
Disease Ontology (DO)mumps0.00006537Highly InformativeDirect
Disease Ontology (DO)Barrett's esophagus0.00006697Highly InformativeDirect
Disease Ontology (DO)gastritis0.0002455Highly InformativeDirect
Disease Ontology (DO)pertussis0.000407Highly InformativeDirect
Disease Ontology (DO)chronic leukemia0.0004181Highly InformativeDirect
Disease Ontology (DO)progressive multifocal leukoencephalopathy0.000511Highly InformativeDirect
Disease Ontology (DO)laryngeal carcinoma0.0005286Highly InformativeDirect
Disease Ontology (DO)hemangioma0.0005527Highly InformativeDirect
Disease Ontology (DO)salivary gland adenoid cystic carcinoma0.0007231Highly InformativeDirect
Disease Ontology (DO)renal cell carcinoma0.0009728Highly InformativeDirect
Disease Ontology (DO)colorectal cancer0.007293Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the immune system0.05012Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.116Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.3523Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.3782Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.4524Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the hand0.03944Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal genital system morphology0.07971Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal inflammatory response0.1091Moderately InformativeInherited
Phenotypic Abnormality (PA)Aplasia/hypoplasia involving the skeleton0.1588Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ear0.3029Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.7711Moderately InformativeInherited
Phenotypic Abnormality (PA)Aplasia/hypoplasia involving bones of the hand0.4297InformativeInherited
Phenotypic Abnormality (PA)Inflammatory abnormality of the eye0.0002788Highly InformativeDirect
Phenotypic Abnormality (PA)Otitis media0.0005834Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the scrotum0.04193Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)growth/size/body region phenotype0.000001671Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0.000002128Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0.0002065Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0.0003583Least InformativeDirect
Mammalian Phenotype (MP)hematopoietic system phenotype0.006192Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.007651Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.02699Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.1987Least InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.000000009881Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal leukocyte physiology0.0000005252Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal skeleton morphology0.0000008238Moderately InformativeDirect
Mammalian Phenotype (MP)integument phenotype0.000001273Moderately InformativeDirect
Mammalian Phenotype (MP)embryo phenotype0.000001904Moderately InformativeDirect
Mammalian Phenotype (MP)respiratory system phenotype0.000005615Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal gland morphology0.000009858Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal craniofacial morphology0.00001004Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.00002916Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal blood cell morphology0.00008639Moderately InformativeDirect
Mammalian Phenotype (MP)liver/biliary system phenotype0.0008602Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal inflammatory response0.001425Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.003659Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.005874Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.01522Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.01998Moderately InformativeInherited
Mammalian Phenotype (MP)decreased hematopoietic cell number0.02797Moderately InformativeInherited
Mammalian Phenotype (MP)neoplasm0.03162Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.03432Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte cell number0.03959Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal myeloid cell morphology0.04786Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.05346Moderately InformativeInherited
Mammalian Phenotype (MP)lethality during fetal growth through weaning0.05797Moderately InformativeInherited
Mammalian Phenotype (MP)prenatal lethality0.08378Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.09986Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.1346Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.4865Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.7245Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin level0.00000001115InformativeDirect
Mammalian Phenotype (MP)increased susceptibility to infection0.0000003055InformativeDirect
Mammalian Phenotype (MP)abnormal liver physiology0.00000328InformativeDirect
Mammalian Phenotype (MP)abnormal thymus morphology0.00001363InformativeDirect
Mammalian Phenotype (MP)abnormal coat appearance0.00002184InformativeDirect
Mammalian Phenotype (MP)abnormal T cell differentiation0.00003065InformativeDirect
Mammalian Phenotype (MP)abnormal fluid regulation0.0000459InformativeDirect
Mammalian Phenotype (MP)normal phenotype0.00006722InformativeDirect
Mammalian Phenotype (MP)abnormal B cell proliferation0.0001236InformativeDirect
Mammalian Phenotype (MP)hemorrhage0.0001376InformativeDirect
Mammalian Phenotype (MP)altered tumor pathology0.0003115InformativeDirect
Mammalian Phenotype (MP)increased leukocyte cell number0.0004478InformativeDirect
Mammalian Phenotype (MP)abnormal cartilage morphology0.002102InformativeInherited
Mammalian Phenotype (MP)abnormal humoral immune response0.003876InformativeInherited
Mammalian Phenotype (MP)abnormal adaptive thermogenesis0.004033InformativeInherited
Mammalian Phenotype (MP)abnormal spinal cord morphology0.008949InformativeInherited
Mammalian Phenotype (MP)abnormal epidermal layer morphology0.009933InformativeInherited
Mammalian Phenotype (MP)abnormal circulating cytokine level0.0122InformativeInherited
Mammalian Phenotype (MP)abnormal gland physiology0.02347InformativeInherited
Mammalian Phenotype (MP)abnormal B lymphocyte antigen presentation0.02841InformativeInherited
Mammalian Phenotype (MP)abnormal lymph node morphology0.04113InformativeInherited
Mammalian Phenotype (MP)abnormal interferon level0.07263InformativeInherited
Mammalian Phenotype (MP)abnormal mammary gland morphology0.075InformativeInherited
Mammalian Phenotype (MP)abnormal appendicular skeleton morphology0.08062InformativeInherited
Mammalian Phenotype (MP)abnormal natural killer cell mediated cytotoxicity0.2422InformativeInherited
Mammalian Phenotype (MP)abnormal thoracic cage morphology0.2453InformativeInherited
Mammalian Phenotype (MP)abnormal facial morphology0.2723InformativeInherited
Mammalian Phenotype (MP)abnormal stomach morphology0.3254InformativeInherited
Mammalian Phenotype (MP)increased hemolymphoid system tumor incidence0.3509InformativeInherited
Mammalian Phenotype (MP)increased carcinoma incidence0.3811InformativeInherited
Mammalian Phenotype (MP)abnormal voluntary movement0.4852InformativeInherited
Mammalian Phenotype (MP)abnormal erythroid lineage cell morphology0.5378InformativeInherited
Mammalian Phenotype (MP)abnormal vertebrae morphology0.6989InformativeInherited
Mammalian Phenotype (MP)abnormal Peyer's patch morphology0.8935InformativeInherited
Mammalian Phenotype (MP)decreased B cell proliferation0.000006631Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mammary gland epithelium physiology0.000009092Highly InformativeDirect
Mammalian Phenotype (MP)respiratory system inflammation0.000009952Highly InformativeDirect
Mammalian Phenotype (MP)lethality throughout fetal growth and development, complete penetrance0.0000263Highly InformativeDirect
Mammalian Phenotype (MP)abnormal secondary palate development0.00006052Highly InformativeDirect
Mammalian Phenotype (MP)abnormal intervertebral disk morphology0.0001088Highly InformativeDirect
Mammalian Phenotype (MP)impaired adaptive thermogenesis0.0001285Highly InformativeDirect
Mammalian Phenotype (MP)decreased dendritic cell number0.0001301Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cervical atlas morphology0.0001551Highly InformativeDirect
Mammalian Phenotype (MP)abnormal stomach epithelium morphology0.0001702Highly InformativeDirect
Mammalian Phenotype (MP)cleft palate0.0002119Highly InformativeDirect
Mammalian Phenotype (MP)abnormal level of surface class II molecules0.0002746Highly InformativeDirect
Mammalian Phenotype (MP)abnormal thymus medulla morphology0.0003086Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart development0.0003243Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating insulin-like growth factor I level0.0005442Highly InformativeDirect
Mammalian Phenotype (MP)increased adenocarcinoma incidence0.0006405Highly InformativeDirect
Mammalian Phenotype (MP)abnormal granulocyte number0.0006496Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mammary gland alveolus morphology0.0008624Highly InformativeDirect
Mammalian Phenotype (MP)abnormal vertebral arch morphology0.0009151Highly InformativeDirect
Mammalian Phenotype (MP)abnormal spinal cord white matter morphology0.009816Highly InformativeInherited
Mammalian Phenotype (MP)abnormal IgG2a level0.01021Highly InformativeInherited
Mammalian Phenotype (MP)abnormal head movements0.01284Highly InformativeInherited
Mammalian Phenotype (MP)increased leukemia incidence0.01367Highly InformativeInherited
Mammalian Phenotype (MP)abnormal bone marrow cell morphology/development0.01856Highly InformativeInherited
Mammalian Phenotype (MP)embryonic lethality during organogenesis0.06131Highly InformativeInherited
Mammalian Phenotype (MP)abnormal Peyer's patch size0.1244Highly InformativeInherited
Mammalian Phenotype (MP)abnormal peripheral lymph node morphology0.1483Highly InformativeInherited
Mammalian Phenotype (MP)abnormal epidermis stratum spinosum morphology0.2187Highly InformativeInherited
Mammalian Phenotype (MP)abnormal neurocranium morphology0.2726Highly InformativeInherited
Mammalian Phenotype (MP)increased IgG level0.3588Highly InformativeInherited
Mammalian Phenotype (MP)abnormal sternum morphology0.8393Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organ system morphology variant0.01661Least InformativeInherited
Worm Phenotype (WP)cell development variant0.03782Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.1015Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.3362Least InformativeInherited
Worm Phenotype (WP)level of transgene expression variant0.00008315Moderately InformativeDirect
Worm Phenotype (WP)cell division variant0.0778Moderately InformativeInherited
Worm Phenotype (WP)pattern of transgene expression variant1Moderately InformativeInherited
Worm Phenotype (WP)ectopic expression transgene0.0004529Highly InformativeDirect
Worm Phenotype (WP)lineage variant0.000493Highly InformativeDirect
Worm Phenotype (WP)gene expression level reduced0.0005031Highly InformativeDirect
Worm Phenotype (WP)alimentary system morphology variant0.0005907Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)cell number defective0.008938InformativeInherited

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)integumentary system0.00003342Least InformativeDirect
Fly Anatomy (FA)adult0.002047Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.005561Least InformativeInherited
Fly Anatomy (FA)anatomical group0.02534Least InformativeInherited
Fly Anatomy (FA)somatic cell0.03047Least InformativeInherited
Fly Anatomy (FA)larva0.09365Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)sense organ0.01305Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.03593Moderately InformativeInherited
Fly Anatomy (FA)adult thorax0.03831Moderately InformativeInherited
Fly Anatomy (FA)thoracic segment0.1144Moderately InformativeInherited
Fly Anatomy (FA)late embryo0.2565Moderately InformativeInherited
Fly Anatomy (FA)tagmatic subdivision of integument0.625Moderately InformativeInherited
Fly Anatomy (FA)mechanosensory system0.0002834InformativeDirect
Fly Anatomy (FA)circulatory system0.001908InformativeInherited
Fly Anatomy (FA)head mesoderm derived embryonic hemocyte0.0001621Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)organism subdivision0.1323Least InformativeInherited
Zebrafish Anatomy (ZA)compound organ0.7076Least InformativeInherited
Zebrafish Anatomy (ZA)multi-tissue structure0.839Least InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.1463Moderately InformativeInherited
Zebrafish Anatomy (ZA)trunk0.164Moderately InformativeInherited
Zebrafish Anatomy (ZA)cardiovascular system0.188Moderately InformativeInherited
Zebrafish Anatomy (ZA)anatomical space0.1223InformativeInherited
Zebrafish Anatomy (ZA)heart0.0231Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.2543Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.2698Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical cluster0.606Least InformativeInherited
Xenopus ANatomical entity (XAN)nervous system0.6251Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.8842Least InformativeInherited
Xenopus ANatomical entity (XAN)cell1Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.002361Moderately InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.006084Moderately InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.2266Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.3678Moderately InformativeInherited
Xenopus ANatomical entity (XAN)anatomical direction0.000007947InformativeDirect
Xenopus ANatomical entity (XAN)pharyngeal region0.000008772InformativeDirect
Xenopus ANatomical entity (XAN)neuroectoderm0.0000115InformativeDirect
Xenopus ANatomical entity (XAN)vestibuloauditory system0.0003493InformativeDirect
Xenopus ANatomical entity (XAN)notochord0.00043InformativeDirect
Xenopus ANatomical entity (XAN)peripheral nervous system0.0404InformativeInherited
Xenopus ANatomical entity (XAN)skeletal system0.2468InformativeInherited
Xenopus ANatomical entity (XAN)heart0.3663InformativeInherited
Xenopus ANatomical entity (XAN)limb0.5969InformativeInherited
Xenopus ANatomical entity (XAN)connective tissue0.8091InformativeInherited
Xenopus ANatomical entity (XAN)solid compound organ0.9496InformativeInherited
Xenopus ANatomical entity (XAN)neurogenic placode0.00000237Highly InformativeDirect
Xenopus ANatomical entity (XAN)mesenchyme0.000004408Highly InformativeDirect
Xenopus ANatomical entity (XAN)involuted ventral mesoderm0.000005103Highly InformativeDirect
Xenopus ANatomical entity (XAN)limb bud0.00004204Highly InformativeDirect
Xenopus ANatomical entity (XAN)hindlimb0.0002152Highly InformativeDirect
Xenopus ANatomical entity (XAN)primordium0.0002827Highly InformativeDirect
Xenopus ANatomical entity (XAN)otic vesicle0.0003815Highly InformativeDirect
Xenopus ANatomical entity (XAN)cranium0.0006765Highly InformativeDirect
Xenopus ANatomical entity (XAN)gustatory system0.00333Highly InformativeInherited
Xenopus ANatomical entity (XAN)cranial nerve0.01493Highly InformativeInherited
Xenopus ANatomical entity (XAN)blastopore lip1Highly InformativeInherited
Xenopus DEvelopment stage (XDE)NF stage0.000228Least InformativeDirect
Xenopus DEvelopment stage (XDE)embryonic stage0.0008018Least InformativeDirect

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis0Moderately InformativeDirect
Biological processTranscription regulation0Moderately InformativeDirect
Biological processCell cycle0.000000000003762Moderately InformativeDirect
Biological processBiological rhythms0InformativeDirect
Biological processNotch signaling pathway0Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentEndoplasmic reticulum0.000000008968Moderately InformativeDirect
Coding sequence diversityAlternative promoter usage0.0002144Moderately InformativeDirect
DiseaseTumor suppressor0Moderately InformativeDirect
DomainCoiled coil0.00008117Moderately InformativeDirect
DomainSH2 domain0InformativeDirect
DomainANK repeat0.0000001036InformativeDirect
Molecular functionZinc0.0001012Least InformativeDirect
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationDNA-binding0Moderately InformativeDirect
Post-translational modificationRepressor0Moderately InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationAcetylation0.00000001431Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationIsopeptide bond0Moderately InformativeDirect
Post-translational modificationMethylation0.000009524Moderately InformativeDirect
Post-translational modificationS-nitrosylation0.00003078InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR008967 SSF49417 Protein matches
Abstract

This domain is found in a number of transcription factors, including p53, NFATC, TonEBP, STAT-1, and NFkappaB, where it is responsible for DNA-binding. These transcription factors play diverse roles in the regulation of cellular functions: the p53 tumour suppressor upregulates the expression of genes involved in cell cycle arrest and apoptosis [PubMed12826037]; NFATC regulates the production of effector proteins involved in coordinating the immune response [PubMed8990122]; TonEBP regulates gene expression induced by osmotic stress and helps regulate intracellular volume during cell growth [PubMed12729611]; STAT-1 plays an important role in B lymphocyte growth and function [PubMed12855573]; and NFkappaB is involved in the inflammatory response [PubMed12421671]. The DNA-binding domain acts to clamp, or in the case of TonEBP, encircle the DNA target in order to stabilize the protein-DNA complex [PubMed11780147]. Protein interactions may also serve to stabilize the protein-DNA complex, for example in the STAT-1 dimer the SH2 (Src homology 2) domain in each monomer is coupled to the DNA-binding domain to increase stability [PubMed9630226]. The DNA-binding domain consists of a beta-sandwich formed of 9 strands in 2 sheets with a Greek-key topology. This structure is found in many transcription factors, often within the DNA-binding domain.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 19 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a p53-like transcription factors domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 19 hidden Markov models representing the p53-like transcription factors superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]