SUPERFAMILY 1.75 HMM library and genome assignments server


p53-like transcription factors superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Common fold of diphtheria toxin/transcription factors/cytochrome f [ 49379] (10)
Superfamily:   p53-like transcription factors [ 49417] (7)
Families:   p53 DNA-binding domain-like [ 81314] (2)
  Rel/Dorsal transcription factors, DNA-binding domain [ 81315] (6)
  T-box [ 81316] (2)
  STAT DNA-binding domain [ 81317] (3)
  RUNT domain [ 81318]
  DNA-binding domain from NDT80 [ 81992]
  DNA-binding protein LAG-1 (CSL) [ 110080]


Superfamily statistics
Genomes (335) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 5,637 6,312 53
Proteins 5,536 6,255 53


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process1.254e-110Least InformativeDirect
Biological Process (BP)developmental process4.679e-110Least InformativeDirect
Biological Process (BP)regulation of cellular process2.874e-085.352e-07Least InformativeDirect
Biological Process (BP)regulation of metabolic process0.0002240Least InformativeDirect
Biological Process (BP)single-organism cellular process0.0057488.683e-12Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.084622.888e-09Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.088284.385e-08Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.11728.639e-09Least InformativeInherited
Biological Process (BP)biosynthetic process0.12580.01033Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.18172.171e-05Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.15240.0007141Least InformativeInherited
Biological Process (BP)regulation of nitrogen compound metabolic process1.568e-130Moderately InformativeDirect
Biological Process (BP)cell differentiation6.872e-130Moderately InformativeDirect
Biological Process (BP)single-organism developmental process3.578e-070Moderately InformativeDirect
Biological Process (BP)positive regulation of metabolic process1.183e-050Moderately InformativeDirect
Biological Process (BP)regulation of multicellular organismal process1.634e-050Moderately InformativeDirect
Biological Process (BP)positive regulation of cellular process2.008e-050Moderately InformativeDirect
Biological Process (BP)regulation of cellular metabolic process3.052e-050Moderately InformativeDirect
Biological Process (BP)regulation of developmental process0.00025240Moderately InformativeDirect
Biological Process (BP)anatomical structure morphogenesis0.00032642.461e-08Moderately InformativeDirect
Biological Process (BP)tissue development0.00069382.076e-15Moderately InformativeDirect
Biological Process (BP)regulation of biosynthetic process0.00072760Moderately InformativeDirect
Biological Process (BP)immune system process0.00073440Moderately InformativeDirect
Biological Process (BP)organ development0.00078370Moderately InformativeDirect
Biological Process (BP)negative regulation of cellular process0.14351.301e-08Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process0.0021670Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process0.0034040Moderately InformativeInherited
Biological Process (BP)cellular nitrogen compound biosynthetic process0.003880Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process0.0053364.008e-15Moderately InformativeInherited
Biological Process (BP)RNA metabolic process0.0013914.34e-12Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.023980Moderately InformativeInherited
Biological Process (BP)cellular macromolecule biosynthetic process0.0027194.032e-14Moderately InformativeInherited
Biological Process (BP)gene expression0.003461.457e-11Moderately InformativeInherited
Biological Process (BP)chordate embryonic development1.161e-100.0007849InformativeDirect
Biological Process (BP)positive regulation of nitrogen compound metabolic process6.011e-060InformativeDirect
Biological Process (BP)transcription, DNA-dependent8.75e-060InformativeDirect
Biological Process (BP)organ morphogenesis5.845e-057.444e-10InformativeDirect
Biological Process (BP)positive regulation of gene expression0.00011440InformativeDirect
Biological Process (BP)embryonic morphogenesis0.00016010InformativeDirect
Biological Process (BP)positive regulation of macromolecule biosynthetic process0.0002370InformativeDirect
Biological Process (BP)positive regulation of cellular biosynthetic process0.00048310InformativeDirect
Biological Process (BP)negative regulation of developmental process0.0023410InformativeInherited
Biological Process (BP)muscle structure development0.0028032.385e-05InformativeInherited
Biological Process (BP)cell activation0.0017670InformativeInherited
Biological Process (BP)hematopoietic or lymphoid organ development0.0076520InformativeInherited
Biological Process (BP)cardiovascular system development0.0093295.607e-14InformativeInherited
Biological Process (BP)hair cycle process4.345e-090Highly InformativeDirect
Biological Process (BP)lymphocyte differentiation7.048e-071.874e-07Highly InformativeDirect
Biological Process (BP)cell fate commitment5.191e-059.431e-12Highly InformativeDirect
Biological Process (BP)stem cell development0.00027463.557e-13Highly InformativeDirect
Biological Process (BP)pattern specification process0.00098230Highly InformativeDirect
Biological Process (BP)epidermis development0.041020.5902Highly InformativeInherited
Molecular Function (MF)binding3.415e-050Least InformativeDirect
Molecular Function (MF)heterocyclic compound binding2.435e-060Moderately InformativeDirect
Molecular Function (MF)organic cyclic compound binding4.009e-060Moderately InformativeDirect
Molecular Function (MF)nucleic acid binding transcription factor activity00InformativeDirect
Molecular Function (MF)DNA binding00InformativeDirect
Molecular Function (MF)chromatin binding2.679e-090Highly InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle7.359e-060Least InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 5.352e-07 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 8.683e-12 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 2.888e-09 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 4.385e-08 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 8.639e-09 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.0007141 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 2.171e-05 Least Informative Direct
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.01033 Least Informative Inherited
Biological Process (BP) localization 0.1884 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) cell differentiation 0 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 0 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 2.461e-08 Moderately Informative Direct
Biological Process (BP) tissue development 2.076e-15 Moderately Informative Direct
Biological Process (BP) regulation of biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) organ development 0 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 4.34e-12 Moderately Informative Direct
Biological Process (BP) multi-organism process 1.221e-06 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 4.032e-14 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) gene expression 1.457e-11 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 4.008e-15 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 3.307e-05 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0 Moderately Informative Direct
Biological Process (BP) response to organic substance 2.592e-06 Moderately Informative Direct
Biological Process (BP) regulation of signaling 1.699e-08 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 1.069e-06 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 1.301e-08 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 1.044e-06 Moderately Informative Direct
Biological Process (BP) reproduction 6.061e-07 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 1.171e-06 Moderately Informative Direct
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.7399 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.0241 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) oxidation-reduction process 0.3042 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.001877 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.07626 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.003089 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.1136 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.01073 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.6288 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) chordate embryonic development 0.0007849 Informative Direct
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0 Informative Direct
Biological Process (BP) transcription, DNA-dependent 0 Informative Direct
Biological Process (BP) organ morphogenesis 7.444e-10 Informative Direct
Biological Process (BP) positive regulation of gene expression 0 Informative Direct
Biological Process (BP) embryonic morphogenesis 0 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0 Informative Direct
Biological Process (BP) tissue morphogenesis 1.152e-13 Informative Direct
Biological Process (BP) cell activation 0 Informative Direct
Biological Process (BP) negative regulation of developmental process 0 Informative Direct
Biological Process (BP) muscle structure development 2.385e-05 Informative Direct
Biological Process (BP) regulation of cell proliferation 0 Informative Direct
Biological Process (BP) hematopoietic or lymphoid organ development 0 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 2.256e-07 Informative Direct
Biological Process (BP) central nervous system development 0.000227 Informative Direct
Biological Process (BP) embryonic organ development 8.604e-07 Informative Direct
Biological Process (BP) cardiovascular system development 5.607e-14 Informative Direct
Biological Process (BP) negative regulation of signaling 0.0009479 Informative Direct
Biological Process (BP) tube development 2.71e-09 Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0 Informative Direct
Biological Process (BP) apoptotic process 0 Informative Direct
Biological Process (BP) cell proliferation 0 Informative Direct
Biological Process (BP) response to cytokine stimulus 0 Informative Direct
Biological Process (BP) intracellular signal transduction 7.154e-11 Informative Direct
Biological Process (BP) response to DNA damage stimulus 2.082e-10 Informative Direct
Biological Process (BP) regulation of growth 9.532e-10 Informative Direct
Biological Process (BP) gland development 5.889e-09 Informative Direct
Biological Process (BP) immune response 9.672e-09 Informative Direct
Biological Process (BP) secretion 3.816e-08 Informative Direct
Biological Process (BP) nucleocytoplasmic transport 3.441e-07 Informative Direct
Biological Process (BP) mitochondrion organization 6.35e-06 Informative Direct
Biological Process (BP) regulation of organelle organization 8.387e-06 Informative Direct
Biological Process (BP) DNA metabolic process 8.512e-06 Informative Direct
Biological Process (BP) response to organic nitrogen 2.681e-05 Informative Direct
Biological Process (BP) regulation of apoptotic process 0.0001013 Informative Direct
Biological Process (BP) protein localization to organelle 0.0001618 Informative Direct
Biological Process (BP) locomotion 0.0006401 Informative Direct
Biological Process (BP) protein transport 0.0007053 Informative Direct
Biological Process (BP) multicellular organismal homeostasis 0.0007197 Informative Direct
Biological Process (BP) negative regulation of cell death 0.0007964 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) regulation of secretion 0.1275 Informative Inherited
Biological Process (BP) regulation of cellular component movement 1 Informative Inherited
Biological Process (BP) regulation of locomotion 1 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 1 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.004891 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.001406 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.3353 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.002886 Informative Inherited
Biological Process (BP) response to inorganic substance 1 Informative Inherited
Biological Process (BP) muscle tissue development 0.9514 Informative Inherited
Biological Process (BP) sensory organ development 0.3495 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.0956 Informative Inherited
Biological Process (BP) reproductive system development 1 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.7157 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 0.01268 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.2413 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.004454 Informative Inherited
Biological Process (BP) single-organism behavior 1 Informative Inherited
Biological Process (BP) cellular membrane organization 0.6125 Informative Inherited
Biological Process (BP) positive regulation of immune system process 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.004177 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.01214 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.08335 Informative Inherited
Biological Process (BP) regulation of cell development 1 Informative Inherited
Biological Process (BP) energy derivation by oxidation of organic compounds 0.005158 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.4471 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 1 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.0475 Informative Inherited
Biological Process (BP) single organism reproductive process 0.5459 Informative Inherited
Biological Process (BP) steroid metabolic process 0.3736 Informative Inherited
Biological Process (BP) cellular ketone metabolic process 0.01774 Informative Inherited
Biological Process (BP) regulation of immune effector process 0.05767 Informative Inherited
Biological Process (BP) positive regulation of protein metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.8461 Informative Inherited
Biological Process (BP) regulation of response to stress 0.7013 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.2289 Informative Inherited
Biological Process (BP) response to lipid 0.696 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.04071 Informative Inherited
Biological Process (BP) regulation of cell cycle process 1 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.5676 Informative Inherited
Biological Process (BP) negative regulation of cellular metabolic process 0.1893 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.05491 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.8308 Informative Inherited
Biological Process (BP) response to other organism 0.9105 Informative Inherited
Biological Process (BP) response to light stimulus 0.06577 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.09803 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.4485 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.9593 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.1089 Informative Inherited
Biological Process (BP) response to external stimulus 1 Informative Inherited
Biological Process (BP) regulation of nervous system development 1 Informative Inherited
Biological Process (BP) cell cycle process 0.02959 Informative Inherited
Biological Process (BP) metal ion transport 0.08441 Informative Inherited
Biological Process (BP) immune effector process 0.9964 Informative Inherited
Biological Process (BP) localization of cell 0.003112 Informative Inherited
Biological Process (BP) cellular component movement 0.8258 Informative Inherited
Biological Process (BP) generation of neurons 0.07063 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) cellular component morphogenesis 1 Informative Inherited
Biological Process (BP) hair cycle process 0 Highly Informative Direct
Biological Process (BP) lymphocyte differentiation 1.874e-07 Highly Informative Direct
Biological Process (BP) cell fate commitment 9.431e-12 Highly Informative Direct
Biological Process (BP) stem cell development 3.557e-13 Highly Informative Direct
Biological Process (BP) pattern specification process 0 Highly Informative Direct
Biological Process (BP) skeletal system development 7.456e-09 Highly Informative Direct
Biological Process (BP) cytokine-mediated signaling pathway 0 Highly Informative Direct
Biological Process (BP) response to ionizing radiation 0 Highly Informative Direct
Biological Process (BP) positive regulation of organelle organization 0 Highly Informative Direct
Biological Process (BP) regulation of epithelial cell differentiation 0 Highly Informative Direct
Biological Process (BP) signal transduction by p53 class mediator 0 Highly Informative Direct
Biological Process (BP) positive regulation of peptidase activity 0 Highly Informative Direct
Biological Process (BP) regulation of G1/S transition of mitotic cell cycle 0 Highly Informative Direct
Biological Process (BP) response to UV 0 Highly Informative Direct
Biological Process (BP) aging 2.615e-14 Highly Informative Direct
Biological Process (BP) signal transduction in response to DNA damage 2.798e-14 Highly Informative Direct
Biological Process (BP) regulation of mitochondrion organization 4.382e-14 Highly Informative Direct
Biological Process (BP) apoptotic signaling pathway 5.086e-14 Highly Informative Direct
Biological Process (BP) protein targeting to nucleus 6.598e-11 Highly Informative Direct
Biological Process (BP) response to purine-containing compound 3.129e-10 Highly Informative Direct
Biological Process (BP) nuclear import 5.62e-10 Highly Informative Direct
Biological Process (BP) protein localization to nucleus 1.044e-09 Highly Informative Direct
Biological Process (BP) regulation of cell cycle arrest 1.577e-09 Highly Informative Direct
Biological Process (BP) regulation of apoptotic signaling pathway 2.07e-09 Highly Informative Direct
Biological Process (BP) regulation of stem cell proliferation 2.249e-09 Highly Informative Direct
Biological Process (BP) regulation of mononuclear cell proliferation 9.371e-09 Highly Informative Direct
Biological Process (BP) regulation of lymphocyte activation 1.019e-08 Highly Informative Direct
Biological Process (BP) protein import 2.832e-08 Highly Informative Direct
Biological Process (BP) cardiocyte differentiation 4.189e-08 Highly Informative Direct
Biological Process (BP) lactation 2.761e-07 Highly Informative Direct
Biological Process (BP) cellular response to peptide hormone stimulus 2.82e-07 Highly Informative Direct
Biological Process (BP) mitochondrial transport 3.659e-07 Highly Informative Direct
Biological Process (BP) regulation of lymphocyte mediated immunity 1.056e-06 Highly Informative Direct
Biological Process (BP) development of primary female sexual characteristics 1.132e-06 Highly Informative Direct
Biological Process (BP) limb morphogenesis 1.929e-06 Highly Informative Direct
Biological Process (BP) negative regulation of cell growth 3.741e-06 Highly Informative Direct
Biological Process (BP) angiogenesis 6.1e-06 Highly Informative Direct
Biological Process (BP) ovulation cycle process 6.314e-06 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 6.773e-06 Highly Informative Direct
Biological Process (BP) cellular response to abiotic stimulus 7.773e-06 Highly Informative Direct
Biological Process (BP) cellular response to metal ion 1.159e-05 Highly Informative Direct
Biological Process (BP) regulation of smooth muscle cell proliferation 1.184e-05 Highly Informative Direct
Biological Process (BP) regulation of cytokine biosynthetic process 1.289e-05 Highly Informative Direct
Biological Process (BP) feeding behavior 1.45e-05 Highly Informative Direct
Biological Process (BP) regulation of multicellular organism growth 1.983e-05 Highly Informative Direct
Biological Process (BP) mitotic cell cycle checkpoint 4.611e-05 Highly Informative Direct
Biological Process (BP) photoreceptor cell differentiation 7.022e-05 Highly Informative Direct
Biological Process (BP) regulation of calcium-mediated signaling 0.0001061 Highly Informative Direct
Biological Process (BP) stem cell proliferation 0.0001617 Highly Informative Direct
Biological Process (BP) leukocyte homeostasis 0.0002336 Highly Informative Direct
Biological Process (BP) calcium ion transport 0.0004144 Highly Informative Direct
Biological Process (BP) regulation of organ morphogenesis 0.0004581 Highly Informative Direct
Biological Process (BP) DNA damage checkpoint 0.0007913 Highly Informative Direct
Biological Process (BP) regulation of neurological system process 0.006195 Highly Informative Inherited
Biological Process (BP) regulation of vesicle-mediated transport 0.966 Highly Informative Inherited
Biological Process (BP) negative regulation of secretion 0.001442 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 0.01108 Highly Informative Inherited
Biological Process (BP) regulation of neural precursor cell proliferation 0.1614 Highly Informative Inherited
Biological Process (BP) negative regulation of locomotion 0.4625 Highly Informative Inherited
Biological Process (BP) negative regulation of cellular component movement 0.4957 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 0.05968 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.09514 Highly Informative Inherited
Biological Process (BP) inner ear development 0.03138 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 0.08568 Highly Informative Inherited
Biological Process (BP) kidney development 0.01334 Highly Informative Inherited
Biological Process (BP) positive regulation of cell cycle process 0.7235 Highly Informative Inherited
Biological Process (BP) cardiac muscle tissue development 0.7319 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 1 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 1 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 1 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.001828 Highly Informative Inherited
Biological Process (BP) glial cell differentiation 0.5339 Highly Informative Inherited
Biological Process (BP) cell cycle phase 0.1698 Highly Informative Inherited
Biological Process (BP) sensory perception 0.002231 Highly Informative Inherited
Biological Process (BP) positive regulation of response to external stimulus 0.00725 Highly Informative Inherited
Biological Process (BP) regulation of inflammatory response 0.01111 Highly Informative Inherited
Biological Process (BP) positive regulation of cell activation 0.4332 Highly Informative Inherited
Biological Process (BP) negative regulation of signal transduction 0.02771 Highly Informative Inherited
Biological Process (BP) regulation of Ras protein signal transduction 0.0397 Highly Informative Inherited
Biological Process (BP) regulation of myeloid cell differentiation 0.006296 Highly Informative Inherited
Biological Process (BP) positive regulation of cell differentiation 0.0603 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 0.08046 Highly Informative Inherited
Biological Process (BP) T cell activation 0.1561 Highly Informative Inherited
Biological Process (BP) epidermis development 0.5902 Highly Informative Inherited
Biological Process (BP) regulation of neuron apoptotic process 0.3001 Highly Informative Inherited
Biological Process (BP) regulation of cell killing 0.04221 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.7845 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.1071 Highly Informative Inherited
Biological Process (BP) regulation of innate immune response 0.1132 Highly Informative Inherited
Biological Process (BP) immune response-regulating signaling pathway 0.9761 Highly Informative Inherited
Biological Process (BP) activation of immune response 1 Highly Informative Inherited
Biological Process (BP) positive regulation of leukocyte proliferation 0.4323 Highly Informative Inherited
Biological Process (BP) cellular response to biotic stimulus 0.007141 Highly Informative Inherited
Biological Process (BP) response to lipopolysaccharide 0.0131 Highly Informative Inherited
Biological Process (BP) regulation of cell adhesion 0.008299 Highly Informative Inherited
Biological Process (BP) regulation of response to nutrient levels 1 Highly Informative Inherited
Biological Process (BP) negative regulation of cell development 0.1677 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis 1 Highly Informative Inherited
Biological Process (BP) positive regulation of apoptotic process 0.001548 Highly Informative Inherited
Biological Process (BP) negative regulation of cellular catabolic process 0.001766 Highly Informative Inherited
Biological Process (BP) cell division 0.6285 Highly Informative Inherited
Biological Process (BP) response to osmotic stress 0.004869 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 0.7839 Highly Informative Inherited
Biological Process (BP) negative regulation of cellular macromolecule biosynthetic process 1 Highly Informative Inherited
Biological Process (BP) negative regulation of cell cycle 0.006295 Highly Informative Inherited
Biological Process (BP) DNA repair 0.003686 Highly Informative Inherited
Biological Process (BP) heart morphogenesis 0.02123 Highly Informative Inherited
Biological Process (BP) positive regulation of immune effector process 0.008845 Highly Informative Inherited
Biological Process (BP) B cell activation 0.9957 Highly Informative Inherited
Biological Process (BP) leukocyte proliferation 0.2354 Highly Informative Inherited
Biological Process (BP) leukocyte activation involved in immune response 0.005267 Highly Informative Inherited
Biological Process (BP) connective tissue development 0.5455 Highly Informative Inherited
Biological Process (BP) ossification 0.2433 Highly Informative Inherited
Biological Process (BP) myeloid leukocyte activation 1 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 0.606 Highly Informative Inherited
Biological Process (BP) gastrulation 0.0898 Highly Informative Inherited
Biological Process (BP) morphogenesis of a branching epithelium 0.1895 Highly Informative Inherited
Biological Process (BP) epithelial tube morphogenesis 0.9822 Highly Informative Inherited
Biological Process (BP) gonad development 0.3855 Highly Informative Inherited
Biological Process (BP) mitotic cell cycle 1 Highly Informative Inherited
Biological Process (BP) cell cycle phase transition 0.06823 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) heterocyclic compound binding 0 Moderately Informative Direct
Molecular Function (MF) organic cyclic compound binding 0 Moderately Informative Direct
Molecular Function (MF) cation binding 0.0002598 Moderately Informative Direct
Molecular Function (MF) anion binding 0.005357 Moderately Informative Inherited
Molecular Function (MF) enzyme regulator activity 0.5564 Moderately Informative Inherited
Molecular Function (MF) protein binding 1 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding transcription factor activity 0 Informative Direct
Molecular Function (MF) DNA binding 0 Informative Direct
Molecular Function (MF) nucleotide binding 2.73e-05 Informative Direct
Molecular Function (MF) transition metal ion binding 0.0001316 Informative Direct
Molecular Function (MF) enzyme binding 0.4113 Informative Inherited
Molecular Function (MF) chromatin binding 0 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0 Highly Informative Direct
Molecular Function (MF) copper ion binding 3.454e-12 Highly Informative Direct
Molecular Function (MF) ATP binding 5.893e-11 Highly Informative Direct
Molecular Function (MF) transcription factor binding transcription factor activity 0.0001893 Highly Informative Direct
Molecular Function (MF) structure-specific DNA binding 1 Highly Informative Inherited
Molecular Function (MF) sequence-specific DNA binding transcription factor activity 1 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) protein complex 9.563e-07 Least Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.1849 Least Informative Inherited
Cellular Component (CC) cytosol 0 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 0 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.003573 Moderately Informative Inherited
Cellular Component (CC) extracellular region 1 Moderately Informative Inherited
Cellular Component (CC) nucleoplasm part 4.156e-08 Informative Direct
Cellular Component (CC) chromosome 1.669e-05 Informative Direct
Cellular Component (CC) extracellular matrix 0.2216 Informative Inherited
Cellular Component (CC) transcription factor complex 0 Highly Informative Direct
Cellular Component (CC) extracellular matrix part 0.01066 Highly Informative Inherited
Cellular Component (CC) proteinaceous extracellular matrix 0.03075 Highly Informative Inherited

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.08259Least InformativeInherited
Disease Ontology (DO)hematologic cancer0.0009686Moderately InformativeDirect
Disease Ontology (DO)gastrointestinal system disease0.004337Moderately InformativeInherited
Disease Ontology (DO)disease by infectious agent0.008893Moderately InformativeInherited
Disease Ontology (DO)genetic disease0.01573Moderately InformativeInherited
Disease Ontology (DO)benign neoplasm0.02533Moderately InformativeInherited
Disease Ontology (DO)inflammatory bowel disease2.847e-06InformativeDirect
Disease Ontology (DO)autosomal dominant disease0.0004064InformativeDirect
Disease Ontology (DO)chronic leukemia0.0004138InformativeDirect
Disease Ontology (DO)laryngeal carcinoma0.0006039InformativeDirect
Disease Ontology (DO)kidney cancer0.003718InformativeInherited
Disease Ontology (DO)physical disorder0.005185InformativeInherited
Disease Ontology (DO)large intestine cancer0.006926InformativeInherited
Disease Ontology (DO)esophageal disease0.007843InformativeInherited
Disease Ontology (DO)lymphoma0.008211InformativeInherited
Disease Ontology (DO)breast carcinoma0.3048InformativeInherited
Disease Ontology (DO)viral infectious disease0.3206InformativeInherited
Disease Ontology (DO)ulcerative colitis8.581e-08Highly InformativeDirect
Disease Ontology (DO)Burkitt's lymphoma3.311e-05Highly InformativeDirect
Disease Ontology (DO)progressive multifocal leukoencephalopathy0.0002483Highly InformativeDirect
Disease Ontology (DO)pertussis0.0005125Highly InformativeDirect
Disease Ontology (DO)hemangioma0.0006494Highly InformativeDirect
Disease Ontology (DO)stomach disease0.005191Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of head and neck0.05366Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.7753Least InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia involving the skeleton0.002953Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the hand0.02097Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the mouth0.4279Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the nail0.01048InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the oral cavity0.02555InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia involving bones of the hand0.04544InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the fingernails0.0001527Highly InformativeDirect
Phenotypic Abnormality (PA)Absent hand0.0002281Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the humerus0.0005462Highly InformativeDirect
Phenotypic Abnormality (PA)Oral cleft0.005583Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the palate0.1207Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging5.443e-06Least InformativeDirect
Mammalian Phenotype (MP)hematopoietic system phenotype0.0001147Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0.0001934Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0.0005381Least InformativeDirect
Mammalian Phenotype (MP)immune system phenotype0.003896Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.03061Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.06974Least InformativeInherited
Mammalian Phenotype (MP)digestive/alimentary phenotype2.256e-08Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal skeleton morphology6.161e-08Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal lymphocyte morphology1.366e-07Moderately InformativeDirect
Mammalian Phenotype (MP)respiratory system phenotype6.844e-07Moderately InformativeDirect
Mammalian Phenotype (MP)integument phenotype3.087e-05Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cell differentiation4.667e-05Moderately InformativeDirect
Mammalian Phenotype (MP)embryogenesis phenotype9.23e-05Moderately InformativeDirect
Mammalian Phenotype (MP)limbs/digits/tail phenotype0.0001301Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal bone marrow cell morphology/development0.0001715Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal leukopoiesis0.0004728Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal gland morphology0.0007091Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal inflammatory response0.0009881Moderately InformativeDirect
Mammalian Phenotype (MP)liver/biliary system phenotype0.002476Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.00327Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune cell physiology0.004852Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell-mediated immunity0.005336Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal adaptive immunity0.006523Moderately InformativeInherited
Mammalian Phenotype (MP)tumorigenesis0.00818Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.02627Moderately InformativeInherited
Mammalian Phenotype (MP)preweaning lethality0.02797Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.03745Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.05314Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell morphology0.1127Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.1693Moderately InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to infection0.5229Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.7619Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood homeostasis1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin level1.799e-08InformativeDirect
Mammalian Phenotype (MP)increased susceptibility to infection1.325e-06InformativeDirect
Mammalian Phenotype (MP)abnormal thymus morphology4.44e-05InformativeDirect
Mammalian Phenotype (MP)abnormal fluid regulation0.0001543InformativeDirect
Mammalian Phenotype (MP)abnormal cranium morphology0.0002252InformativeDirect
Mammalian Phenotype (MP)increased leukocyte cell number0.0007344InformativeDirect
Mammalian Phenotype (MP)abnormal T cell differentiation0.002443InformativeInherited
Mammalian Phenotype (MP)abnormal hepatobiliary system physiology0.0028InformativeInherited
Mammalian Phenotype (MP)abnormal adaptive thermogenesis0.005192InformativeInherited
Mammalian Phenotype (MP)abnormal humoral immune response0.01067InformativeInherited
Mammalian Phenotype (MP)abnormal antigen presentation0.01488InformativeInherited
Mammalian Phenotype (MP)abnormal cartilage morphology0.01508InformativeInherited
Mammalian Phenotype (MP)abnormal mammary gland morphology0.02806InformativeInherited
Mammalian Phenotype (MP)abnormal lymph node morphology0.05264InformativeInherited
Mammalian Phenotype (MP)abnormal T cell physiology0.05427InformativeInherited
Mammalian Phenotype (MP)abnormal circulating cytokine level0.05901InformativeInherited
Mammalian Phenotype (MP)abnormal epidermal layer morphology0.06385InformativeInherited
Mammalian Phenotype (MP)abnormal B cell physiology0.07715InformativeInherited
Mammalian Phenotype (MP)abnormal interferon level0.08446InformativeInherited
Mammalian Phenotype (MP)abnormal innate immunity0.1167InformativeInherited
Mammalian Phenotype (MP)decreased hematopoietic cell number0.1382InformativeInherited
Mammalian Phenotype (MP)increased hemolymphoid system tumor incidence0.1984InformativeInherited
Mammalian Phenotype (MP)prenatal lethality0.2097InformativeInherited
Mammalian Phenotype (MP)increased inflammatory response0.2348InformativeInherited
Mammalian Phenotype (MP)abnormal stomach morphology0.2687InformativeInherited
Mammalian Phenotype (MP)abnormal effector T cell morphology0.3113InformativeInherited
Mammalian Phenotype (MP)abnormal head morphology0.3192InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation0.3198InformativeInherited
Mammalian Phenotype (MP)abnormal circulating hormone level0.3577InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial development0.3996InformativeInherited
Mammalian Phenotype (MP)abnormal appendicular skeleton morphology0.4713InformativeInherited
Mammalian Phenotype (MP)abnormal vertebrae morphology0.6248InformativeInherited
Mammalian Phenotype (MP)abnormal Peyer's patch morphology0.9228InformativeInherited
Mammalian Phenotype (MP)abnormal spinal cord dorsal column morphology4.005e-06Highly InformativeDirect
Mammalian Phenotype (MP)respiratory system inflammation2.457e-05Highly InformativeDirect
Mammalian Phenotype (MP)decreased dendritic cell number7.946e-05Highly InformativeDirect
Mammalian Phenotype (MP)decreased IgG level8.365e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mammary gland development8.873e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal vertebral arch morphology0.0001607Highly InformativeDirect
Mammalian Phenotype (MP)abnormal thymus medulla morphology0.0001634Highly InformativeDirect
Mammalian Phenotype (MP)abnormal intervertebral disk morphology0.000176Highly InformativeDirect
Mammalian Phenotype (MP)abnormal stomach epithelium morphology0.0002315Highly InformativeDirect
Mammalian Phenotype (MP)abnormal B cell proliferation0.0002467Highly InformativeDirect
Mammalian Phenotype (MP)impaired adaptive thermogenesis0.000258Highly InformativeDirect
Mammalian Phenotype (MP)abnormal tail bud morphology0.000296Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cervical atlas morphology0.0003521Highly InformativeDirect
Mammalian Phenotype (MP)impaired natural killer cell mediated cytotoxicity0.0004678Highly InformativeDirect
Mammalian Phenotype (MP)abnormal level of surface class II molecules0.0004854Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mammary gland alveolus morphology0.0006491Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating insulin-like growth factor I level0.0007785Highly InformativeDirect
Mammalian Phenotype (MP)no abnormal phenotype detected0.0008621Highly InformativeDirect
Mammalian Phenotype (MP)leukemia0.005018Highly InformativeInherited
Mammalian Phenotype (MP)abnormal erythropoiesis0.01545Highly InformativeInherited
Mammalian Phenotype (MP)embryonic lethality during organogenesis0.07026Highly InformativeInherited
Mammalian Phenotype (MP)abnormal Peyer's patch size0.1076Highly InformativeInherited
Mammalian Phenotype (MP)abnormal epidermis stratum spinosum morphology0.1124Highly InformativeInherited
Mammalian Phenotype (MP)abnormal peripheral lymph node morphology0.1529Highly InformativeInherited
Mammalian Phenotype (MP)abnormal palate morphology0.2904Highly InformativeInherited
Mammalian Phenotype (MP)abnormal neurocranium morphology0.4947Highly InformativeInherited
Mammalian Phenotype (MP)abnormal pectoral girdle bone morphology0.6405Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.791Least InformativeInherited
Worm Phenotype (WP)alimentary system morphology variant0.0007835Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0.04558Least InformativeInherited
Fly Anatomy (FA)cell0.08259Least InformativeInherited
Fly Anatomy (FA)organ system0.09098Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)late embryo0.1998Moderately InformativeInherited
Fly Anatomy (FA)circulatory system0.000189InformativeDirect
Fly Anatomy (FA)anatomical space1InformativeInherited
Fly Anatomy (FA)embryonic/larval circulatory system2.208e-05Highly InformativeDirect
Fly Anatomy (FA)head mesoderm derived embryonic hemocyte7.683e-05Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)portion of tissue0.1682Least InformativeInherited
Zebrafish Anatomy (ZA)paraxial mesoderm4.448e-05Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.08315Least InformativeInherited
Xenopus ANatomical entity (XAN)portion of tissue0.4556Least InformativeInherited
Xenopus ANatomical entity (XAN)central nervous system0.6501Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.7437Least InformativeInherited
Xenopus ANatomical entity (XAN)viscus0.8766Least InformativeInherited
Xenopus ANatomical entity (XAN)cell1Least InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.001058Moderately InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.04643Moderately InformativeInherited
Xenopus ANatomical entity (XAN)surface structure0.09241Moderately InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.178Moderately InformativeInherited
Xenopus ANatomical entity (XAN)sensory system0.2734Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.7404Moderately InformativeInherited
Xenopus ANatomical entity (XAN)anatomical direction5.261e-06InformativeDirect
Xenopus ANatomical entity (XAN)notochord5.534e-06InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0.0002064InformativeDirect
Xenopus ANatomical entity (XAN)neural plate0.0002198InformativeDirect
Xenopus ANatomical entity (XAN)vestibuloauditory system0.0002988InformativeDirect
Xenopus ANatomical entity (XAN)pharyngeal region0.0003396InformativeDirect
Xenopus ANatomical entity (XAN)primordium0.002632InformativeInherited
Xenopus ANatomical entity (XAN)heart0.5467InformativeInherited
Xenopus ANatomical entity (XAN)fused heart primordium3.258e-06Highly InformativeDirect
Xenopus ANatomical entity (XAN)mesenchyme2.931e-05Highly InformativeDirect
Xenopus ANatomical entity (XAN)limb bud4.62e-05Highly InformativeDirect
Xenopus ANatomical entity (XAN)pharyngeal arch0.0002625Highly InformativeDirect
Xenopus ANatomical entity (XAN)non-neural ectoderm0.0004533Highly InformativeDirect
Xenopus ANatomical entity (XAN)optic vesicle0.0005324Highly InformativeDirect
Xenopus ANatomical entity (XAN)retina0.0007775Highly InformativeDirect
Xenopus ANatomical entity (XAN)circumblastoporal collar0.005436Highly InformativeInherited
Xenopus ANatomical entity (XAN)marginal zone0.7335Highly InformativeInherited
Xenopus DEvelopment stage (XDE)embryonic stage0.0007032Least InformativeDirect

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis0Moderately InformativeDirect
Biological processTranscription regulation0Moderately InformativeDirect
Biological processCell cycle4.362e-12Moderately InformativeDirect
Biological processNotch signaling pathway0Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentEndoplasmic reticulum1.353e-07Moderately InformativeDirect
Coding sequence diversityAlternative promoter usage6.193e-05Moderately InformativeDirect
DiseaseTumor suppressor0Moderately InformativeDirect
DomainSH2 domain0InformativeDirect
DomainANK repeat2.118e-07InformativeDirect
Molecular functionDNA-binding0Moderately InformativeDirect
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationRepressor3.62e-10Moderately InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationIsopeptide bond0Moderately InformativeDirect
Post-translational modificationMethylation7.616e-07Moderately InformativeDirect
Post-translational modificationAcetylation3.081e-05Moderately InformativeDirect
Post-translational modificationS-nitrosylation2.241e-07InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR008967 SSF49417 Protein matches
Abstract

This domain is found in a number of transcription factors, including p53, NFATC, TonEBP, STAT-1, and NFkappaB, where it is responsible for DNA-binding. These transcription factors play diverse roles in the regulation of cellular functions: the p53 tumour suppressor upregulates the expression of genes involved in cell cycle arrest and apoptosis [PubMed12826037]; NFATC regulates the production of effector proteins involved in coordinating the immune response [PubMed8990122]; TonEBP regulates gene expression induced by osmotic stress and helps regulate intracellular volume during cell growth [PubMed12729611]; STAT-1 plays an important role in B lymphocyte growth and function [PubMed12855573]; and NFkappaB is involved in the inflammatory response [PubMed12421671]. The DNA-binding domain acts to clamp, or in the case of TonEBP, encircle the DNA target in order to stabilize the protein-DNA complex [PubMed11780147]. Protein interactions may also serve to stabilize the protein-DNA complex, for example in the STAT-1 dimer the SH2 (Src homology 2) domain in each monomer is coupled to the DNA-binding domain to increase stability [PubMed9630226]. The DNA-binding domain consists of a beta-sandwich formed of 9 strands in 2 sheets with a Greek-key topology. This structure is found in many transcription factors, often within the DNA-binding domain.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 19 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a p53-like transcription factors domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 19 hidden Markov models representing the p53-like transcription factors superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]