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p53-like transcription factors superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Common fold of diphtheria toxin/transcription factors/cytochrome f [ 49379] (10)
Superfamily:   p53-like transcription factors [ 49417] (7)
Families:   p53 DNA-binding domain-like [ 81314] (2)
  Rel/Dorsal transcription factors, DNA-binding domain [ 81315] (6)
  T-box [ 81316] (2)
  STAT DNA-binding domain [ 81317] (3)
  RUNT domain [ 81318]
  DNA-binding domain from NDT80 [ 81992]
  DNA-binding protein LAG-1 (CSL) [ 110080]


Superfamily statistics
Genomes (367) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 6,320 0 53
Proteins 6,210 0 53


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.1037Least InformativeInherited
Disease Ontology (DO)hematologic cancer0.00143Moderately InformativeInherited
Disease Ontology (DO)disease by infectious agent0.00476Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.01038Moderately InformativeInherited
Disease Ontology (DO)benign neoplasm0.02442Moderately InformativeInherited
Disease Ontology (DO)head and neck carcinoma0.0000002741InformativeDirect
Disease Ontology (DO)inflammatory bowel disease0.000002613InformativeDirect
Disease Ontology (DO)connective tissue cancer0.0000925InformativeDirect
Disease Ontology (DO)physical disorder0.001181InformativeInherited
Disease Ontology (DO)lymphoma0.007253InformativeInherited
Disease Ontology (DO)breast cancer0.008725InformativeInherited
Disease Ontology (DO)cell type benign neoplasm0.01084InformativeInherited
Disease Ontology (DO)respiratory system cancer0.1013InformativeInherited
Disease Ontology (DO)viral infectious disease0.2662InformativeInherited
Disease Ontology (DO)colitis0.00000008629Highly InformativeDirect
Disease Ontology (DO)Burkitt lymphoma0.00002689Highly InformativeDirect
Disease Ontology (DO)mumps0.00006567Highly InformativeDirect
Disease Ontology (DO)Barrett's esophagus0.00007215Highly InformativeDirect
Disease Ontology (DO)gastritis0.0002477Highly InformativeDirect
Disease Ontology (DO)chronic leukemia0.0003982Highly InformativeDirect
Disease Ontology (DO)pertussis0.0004111Highly InformativeDirect
Disease Ontology (DO)progressive multifocal leukoencephalopathy0.0005128Highly InformativeDirect
Disease Ontology (DO)laryngeal carcinoma0.0005345Highly InformativeDirect
Disease Ontology (DO)hemangioma0.0005531Highly InformativeDirect
Disease Ontology (DO)salivary gland adenoid cystic carcinoma0.0007319Highly InformativeDirect
Disease Ontology (DO)large intestine cancer0.007557Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the skeletal system0.08514Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the head0.1874Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.2941Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limb bone morphology0.06563Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper limb0.1226Moderately InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.1467Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.1893Moderately InformativeInherited
Phenotypic Abnormality (PA)Aplasia/hypoplasia of the extremities0.01635InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the thorax0.2767InformativeInherited
Phenotypic Abnormality (PA)Lymphoma0.0003856Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the scapula0.01303Highly InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia involving bones of the thorax0.03148Highly InformativeInherited
Phenotypic Abnormality (PA)Aplasia/hypoplasia involving bones of the hand0.214Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)growth/size/body region phenotype0.000001618Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0.000002057Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0.0002043Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0.0003428Least InformativeDirect
Mammalian Phenotype (MP)hematopoietic system phenotype0.006138Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.007601Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.02695Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.1979Least InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.000000009932Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal leukocyte physiology0.0000005047Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal skeleton morphology0.0000008249Moderately InformativeDirect
Mammalian Phenotype (MP)integument phenotype0.000001224Moderately InformativeDirect
Mammalian Phenotype (MP)embryo phenotype0.000001855Moderately InformativeDirect
Mammalian Phenotype (MP)respiratory system phenotype0.000005462Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal craniofacial morphology0.000009344Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal gland morphology0.000009671Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.0000288Moderately InformativeDirect
Mammalian Phenotype (MP)limbs/digits/tail phenotype0.00005805Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal blood cell morphology0.00008736Moderately InformativeDirect
Mammalian Phenotype (MP)liver/biliary system phenotype0.0008538Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal inflammatory response0.001447Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.003599Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.005896Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.01523Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.02008Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.03062Moderately InformativeInherited
Mammalian Phenotype (MP)neoplasm0.03181Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.03402Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal myeloid cell morphology0.04819Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.05444Moderately InformativeInherited
Mammalian Phenotype (MP)lethality during fetal growth through weaning0.05862Moderately InformativeInherited
Mammalian Phenotype (MP)prenatal lethality0.08278Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.1005Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.1334Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.4832Moderately InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to infection0.5429Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.7244Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin level0.00000001081InformativeDirect
Mammalian Phenotype (MP)increased susceptibility to infection0.00000031InformativeDirect
Mammalian Phenotype (MP)abnormal liver physiology0.000003222InformativeDirect
Mammalian Phenotype (MP)abnormal thymus morphology0.00001349InformativeDirect
Mammalian Phenotype (MP)abnormal coat appearance0.00001997InformativeDirect
Mammalian Phenotype (MP)abnormal T cell differentiation0.00003041InformativeDirect
Mammalian Phenotype (MP)abnormal fluid regulation0.0000474InformativeDirect
Mammalian Phenotype (MP)normal phenotype0.00006735InformativeDirect
Mammalian Phenotype (MP)abnormal B cell proliferation0.0001198InformativeDirect
Mammalian Phenotype (MP)hemorrhage0.0001364InformativeDirect
Mammalian Phenotype (MP)altered tumor pathology0.0003108InformativeDirect
Mammalian Phenotype (MP)increased leukocyte cell number0.0004406InformativeDirect
Mammalian Phenotype (MP)abnormal cartilage morphology0.002063InformativeInherited
Mammalian Phenotype (MP)abnormal humoral immune response0.003872InformativeInherited
Mammalian Phenotype (MP)abnormal adaptive thermogenesis0.004066InformativeInherited
Mammalian Phenotype (MP)abnormal spinal cord morphology0.00887InformativeInherited
Mammalian Phenotype (MP)abnormal epidermal layer morphology0.0102InformativeInherited
Mammalian Phenotype (MP)abnormal circulating cytokine level0.01193InformativeInherited
Mammalian Phenotype (MP)abnormal gland physiology0.02271InformativeInherited
Mammalian Phenotype (MP)abnormal B lymphocyte antigen presentation0.02865InformativeInherited
Mammalian Phenotype (MP)abnormal lymph node morphology0.04133InformativeInherited
Mammalian Phenotype (MP)abnormal head morphology0.04139InformativeInherited
Mammalian Phenotype (MP)abnormal interferon level0.07153InformativeInherited
Mammalian Phenotype (MP)abnormal mammary gland morphology0.07609InformativeInherited
Mammalian Phenotype (MP)abnormal appendicular skeleton morphology0.08045InformativeInherited
Mammalian Phenotype (MP)abnormal thoracic cage morphology0.2411InformativeInherited
Mammalian Phenotype (MP)abnormal natural killer cell mediated cytotoxicity0.2424InformativeInherited
Mammalian Phenotype (MP)abnormal stomach morphology0.3271InformativeInherited
Mammalian Phenotype (MP)increased hemolymphoid system tumor incidence0.3509InformativeInherited
Mammalian Phenotype (MP)increased carcinoma incidence0.3809InformativeInherited
Mammalian Phenotype (MP)abnormal voluntary movement0.4858InformativeInherited
Mammalian Phenotype (MP)abnormal erythroid lineage cell morphology0.5392InformativeInherited
Mammalian Phenotype (MP)abnormal vertebrae morphology0.6966InformativeInherited
Mammalian Phenotype (MP)abnormal Peyer's patch morphology0.8936InformativeInherited
Mammalian Phenotype (MP)decreased B cell proliferation0.000006255Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mammary gland epithelium physiology0.000009155Highly InformativeDirect
Mammalian Phenotype (MP)respiratory system inflammation0.000009671Highly InformativeDirect
Mammalian Phenotype (MP)lethality throughout fetal growth and development, complete penetrance0.00002662Highly InformativeDirect
Mammalian Phenotype (MP)abnormal secondary palate development0.000061Highly InformativeDirect
Mammalian Phenotype (MP)abnormal intervertebral disk morphology0.0001114Highly InformativeDirect
Mammalian Phenotype (MP)impaired adaptive thermogenesis0.0001292Highly InformativeDirect
Mammalian Phenotype (MP)decreased dendritic cell number0.0001311Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cervical atlas morphology0.0001414Highly InformativeDirect
Mammalian Phenotype (MP)abnormal stomach epithelium morphology0.0001709Highly InformativeDirect
Mammalian Phenotype (MP)cleft palate0.0002133Highly InformativeDirect
Mammalian Phenotype (MP)abnormal level of surface class II molecules0.0002753Highly InformativeDirect
Mammalian Phenotype (MP)abnormal thymus medulla morphology0.0003095Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart development0.0003211Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating insulin-like growth factor I level0.0005464Highly InformativeDirect
Mammalian Phenotype (MP)increased adenocarcinoma incidence0.0006237Highly InformativeDirect
Mammalian Phenotype (MP)abnormal granulocyte number0.0006578Highly InformativeDirect
Mammalian Phenotype (MP)abnormal vertebral arch morphology0.0008301Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mammary gland alveolus morphology0.0008657Highly InformativeDirect
Mammalian Phenotype (MP)abnormal spinal cord white matter morphology0.008986Highly InformativeInherited
Mammalian Phenotype (MP)abnormal IgG2a level0.01026Highly InformativeInherited
Mammalian Phenotype (MP)abnormal head movements0.01288Highly InformativeInherited
Mammalian Phenotype (MP)increased leukemia incidence0.01364Highly InformativeInherited
Mammalian Phenotype (MP)abnormal bone marrow cell morphology/development0.01871Highly InformativeInherited
Mammalian Phenotype (MP)embryonic lethality during organogenesis0.06056Highly InformativeInherited
Mammalian Phenotype (MP)abnormal Peyer's patch size0.1245Highly InformativeInherited
Mammalian Phenotype (MP)abnormal peripheral lymph node morphology0.1484Highly InformativeInherited
Mammalian Phenotype (MP)abnormal epidermis stratum spinosum morphology0.219Highly InformativeInherited
Mammalian Phenotype (MP)abnormal neurocranium morphology0.2655Highly InformativeInherited
Mammalian Phenotype (MP)increased IgG level0.3557Highly InformativeInherited
Mammalian Phenotype (MP)abnormal sternum morphology0.8444Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organ system morphology variant0.01704Least InformativeInherited
Worm Phenotype (WP)cell development variant0.03895Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.05468Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.2015Least InformativeInherited
Worm Phenotype (WP)level of transgene expression variant0.0007574Moderately InformativeDirect
Worm Phenotype (WP)cell division variant0.04409Moderately InformativeInherited
Worm Phenotype (WP)pattern of transgene expression variant1Moderately InformativeInherited
Worm Phenotype (WP)lineage variant0.0005078Highly InformativeDirect
Worm Phenotype (WP)alimentary system morphology variant0.0005872Highly InformativeDirect
Worm Phenotype (WP)ectopic expression transgene0.0006075Highly InformativeDirect
Worm Phenotype (WP)gene expression level reduced0.0007301Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)cell number defective0.009122InformativeInherited
Fly Phenotype (FP)cell size defective0.0222Highly InformativeInherited

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)integumentary system0.00003957Least InformativeDirect
Fly Anatomy (FA)adult0.002437Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.00643Least InformativeInherited
Fly Anatomy (FA)anatomical group0.02505Least InformativeInherited
Fly Anatomy (FA)somatic cell0.03398Least InformativeInherited
Fly Anatomy (FA)larva0.1034Least InformativeInherited
Fly Anatomy (FA)embryo0.2065Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)sense organ0.01278Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.0322Moderately InformativeInherited
Fly Anatomy (FA)adult thorax0.03508Moderately InformativeInherited
Fly Anatomy (FA)late embryo0.06107Moderately InformativeInherited
Fly Anatomy (FA)thoracic segment0.1071Moderately InformativeInherited
Fly Anatomy (FA)tagmatic subdivision of integument0.5368Moderately InformativeInherited
Fly Anatomy (FA)mechanosensory system0.0002679InformativeDirect
Fly Anatomy (FA)circulatory system0.001722InformativeInherited
Fly Anatomy (FA)anatomical space0.001939InformativeInherited
Fly Anatomy (FA)head mesoderm derived embryonic hemocyte0.0001664Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)compound organ0.6944Least InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.1234Moderately InformativeInherited
Zebrafish Anatomy (ZA)cardiovascular system0.1721Moderately InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)tissue0.1038Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.2129Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.5646Least InformativeInherited
Xenopus ANatomical entity (XAN)nervous system0.629Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.9307Least InformativeInherited
Xenopus ANatomical entity (XAN)trunk1Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.000002843Moderately InformativeDirect
Xenopus ANatomical entity (XAN)sensory system0.0002188Moderately InformativeDirect
Xenopus ANatomical entity (XAN)embryonic structure0.004059Moderately InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.1541Moderately InformativeInherited
Xenopus ANatomical entity (XAN)viscus0.737Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.7704Moderately InformativeInherited
Xenopus ANatomical entity (XAN)brain0.9756Moderately InformativeInherited
Xenopus ANatomical entity (XAN)mesenchyme0.000002037InformativeDirect
Xenopus ANatomical entity (XAN)pharyngeal region0.0000128InformativeDirect
Xenopus ANatomical entity (XAN)neural plate0.00001331InformativeDirect
Xenopus ANatomical entity (XAN)anatomical direction0.0000143InformativeDirect
Xenopus ANatomical entity (XAN)cardiovascular system0.00002203InformativeDirect
Xenopus ANatomical entity (XAN)cranial placode0.0001442InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0.0001724InformativeDirect
Xenopus ANatomical entity (XAN)hindbrain0.0009321InformativeDirect
Xenopus ANatomical entity (XAN)forebrain0.0009784InformativeDirect
Xenopus ANatomical entity (XAN)peripheral nervous system0.002861InformativeInherited
Xenopus ANatomical entity (XAN)surface structure0.03267InformativeInherited
Xenopus ANatomical entity (XAN)skeletal system0.115InformativeInherited
Xenopus ANatomical entity (XAN)limb0.6265InformativeInherited
Xenopus ANatomical entity (XAN)solid compound organ0.8084InformativeInherited
Xenopus ANatomical entity (XAN)neurogenic placode0.000004554Highly InformativeDirect
Xenopus ANatomical entity (XAN)involuted ventral mesoderm0.00001334Highly InformativeDirect
Xenopus ANatomical entity (XAN)blastema0.0002531Highly InformativeDirect
Xenopus ANatomical entity (XAN)hindlimb0.000259Highly InformativeDirect
Xenopus ANatomical entity (XAN)neuron0.0005667Highly InformativeDirect
Xenopus ANatomical entity (XAN)primordium0.000735Highly InformativeDirect
Xenopus ANatomical entity (XAN)cranium0.00106Highly InformativeInherited
Xenopus ANatomical entity (XAN)cranial nerve0.02151Highly InformativeInherited
Xenopus ANatomical entity (XAN)gustatory system0.02517Highly InformativeInherited
Xenopus ANatomical entity (XAN)branchial arch0.2311Highly InformativeInherited
Xenopus DEvelopment stage (XDE)post-embryonic stage0.7547Least InformativeInherited
Xenopus DEvelopment stage (XDE)premetamorphosis stage0.0003383Highly InformativeDirect

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis0Moderately InformativeDirect
Biological processTranscription regulation0Moderately InformativeDirect
Biological processCell cycle0.00000000001002Moderately InformativeDirect
Biological processDifferentiation0.000003567Moderately InformativeDirect
Biological processBiological rhythms0InformativeDirect
Biological processNotch signaling pathway0Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentEndoplasmic reticulum0.0000000007353Moderately InformativeDirect
Coding sequence diversityAlternative promoter usage0.000272Moderately InformativeDirect
DiseaseTumor suppressor0Moderately InformativeDirect
DomainCoiled coil0.0001218Moderately InformativeDirect
DomainSH2 domain0InformativeDirect
DomainANK repeat0.0000001247InformativeDirect
Molecular functionZinc0.0001578Least InformativeDirect
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationDNA-binding0Moderately InformativeDirect
Post-translational modificationRepressor0Moderately InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationAcetylation0.00000000222Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationIsopeptide bond0Moderately InformativeDirect
Post-translational modificationMethylation0.0000007651Moderately InformativeDirect
Post-translational modificationS-nitrosylation0.00005412InformativeDirect
Post-translational modificationADP-ribosylation0.00008918InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR008967 SSF49417 Protein matches
Abstract

This domain is found in a number of transcription factors, including p53, NFATC, TonEBP, STAT-1, and NFkappaB, where it is responsible for DNA-binding. These transcription factors play diverse roles in the regulation of cellular functions: the p53 tumour suppressor upregulates the expression of genes involved in cell cycle arrest and apoptosis [PubMed12826037]; NFATC regulates the production of effector proteins involved in coordinating the immune response [PubMed8990122]; TonEBP regulates gene expression induced by osmotic stress and helps regulate intracellular volume during cell growth [PubMed12729611]; STAT-1 plays an important role in B lymphocyte growth and function [PubMed12855573]; and NFkappaB is involved in the inflammatory response [PubMed12421671]. The DNA-binding domain acts to clamp, or in the case of TonEBP, encircle the DNA target in order to stabilize the protein-DNA complex [PubMed11780147]. Protein interactions may also serve to stabilize the protein-DNA complex, for example in the STAT-1 dimer the SH2 (Src homology 2) domain in each monomer is coupled to the DNA-binding domain to increase stability [PubMed9630226]. The DNA-binding domain consists of a beta-sandwich formed of 9 strands in 2 sheets with a Greek-key topology. This structure is found in many transcription factors, often within the DNA-binding domain.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 19 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a p53-like transcription factors domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 19 hidden Markov models representing the p53-like transcription factors superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]