SUPERFAMILY 1.75 HMM library and genome assignments server

C2 domain (Calcium/lipid-binding domain, CaLB) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   C2 domain-like [ 49561] (5)
Superfamily:   C2 domain (Calcium/lipid-binding domain, CaLB) [ 49562] (2)
Families:   PLC-like (P variant) [ 49563] (11)
  Synaptotagmin-like (S variant) [ 49575] (10)


Superfamily statistics
Genomes (506) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 47,018 45,964 37
Proteins 31,205 30,598 35


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular component organization or biogenesis0.41720.000000009086Least InformativeInherited
Biological Process (BP)single-organism membrane organization0.00057840.000006812InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 0.0006368 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.000000009086 Least Informative Direct
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) response to stimulus 0.000000000001595 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.0000000000003584 Least Informative Direct
Biological Process (BP) positive regulation of biological process 0.1426 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.7572 Least Informative Inherited
Biological Process (BP) developmental process 0.1306 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.005243 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.001784 Least Informative Inherited
Biological Process (BP) cellular localization 0 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0 Moderately Informative Direct
Biological Process (BP) lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of localization 0 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of phosphorus metabolic process 0.00000001269 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.00000001302 Moderately Informative Direct
Biological Process (BP) immune system process 0.0000005324 Moderately Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 0.000009583 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.00002721 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.5709 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.1818 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.0736 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.009637 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.07304 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.006863 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.01264 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.7487 Moderately Informative Inherited
Biological Process (BP) organ development 0.4608 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 1 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 0.8719 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.5324 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.8898 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.002234 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) defense response 0.4999 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.8685 Moderately Informative Inherited
Biological Process (BP) single-organism organelle organization 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.001813 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.001047 Moderately Informative Inherited
Biological Process (BP) reproductive process 0.4751 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.02262 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.1635 Moderately Informative Inherited
Biological Process (BP) tissue development 0.9331 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) single-organism membrane organization 0.000006812 Informative Direct
Biological Process (BP) secretion by cell 0 Informative Direct
Biological Process (BP) vesicle-mediated transport 0 Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 0 Informative Direct
Biological Process (BP) glycerolipid metabolic process 0 Informative Direct
Biological Process (BP) synaptic transmission 0 Informative Direct
Biological Process (BP) phospholipid metabolic process 0 Informative Direct
Biological Process (BP) positive regulation of transport 0.00000000000002591 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.000000000001195 Informative Direct
Biological Process (BP) positive regulation of catabolic process 0.0000000005938 Informative Direct
Biological Process (BP) cation homeostasis 0.00000001174 Informative Direct
Biological Process (BP) negative regulation of transport 0.00000001695 Informative Direct
Biological Process (BP) alcohol metabolic process 0.00000009136 Informative Direct
Biological Process (BP) organelle localization 0.0000001131 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0.0000004844 Informative Direct
Biological Process (BP) protein catabolic process 0.0000008997 Informative Direct
Biological Process (BP) locomotion 0.000001234 Informative Direct
Biological Process (BP) regulation of response to wounding 0.000001301 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0.000001782 Informative Direct
Biological Process (BP) leukocyte activation 0.000002346 Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 0.000006251 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.00001197 Informative Direct
Biological Process (BP) response to organonitrogen compound 0.00001268 Informative Direct
Biological Process (BP) cellular chemical homeostasis 0.00002873 Informative Direct
Biological Process (BP) cellular macromolecular complex assembly 0.0000393 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0.00009471 Informative Direct
Biological Process (BP) regulation of secretion 0.0001016 Informative Direct
Biological Process (BP) regulation of locomotion 0.000212 Informative Direct
Biological Process (BP) negative regulation of cell death 0.0006107 Informative Direct
Biological Process (BP) immune response 0.0007257 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0.0009649 Informative Direct
Biological Process (BP) positive regulation of cellular protein metabolic process 0.7723 Informative Inherited
Biological Process (BP) positive regulation of gene expression 1 Informative Inherited
Biological Process (BP) regulation of cell activation 0.01098 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.1104 Informative Inherited
Biological Process (BP) cellular response to hormone stimulus 0.5431 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.1803 Informative Inherited
Biological Process (BP) metal ion transport 0.05082 Informative Inherited
Biological Process (BP) response to inorganic substance 0.1627 Informative Inherited
Biological Process (BP) neurological system process 0.7406 Informative Inherited
Biological Process (BP) anion transport 1 Informative Inherited
Biological Process (BP) organic acid transport 1 Informative Inherited
Biological Process (BP) organ morphogenesis 0.03212 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.2455 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.7138 Informative Inherited
Biological Process (BP) regulation of cell development 0.04122 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.2119 Informative Inherited
Biological Process (BP) cardiovascular system development 0.02406 Informative Inherited
Biological Process (BP) organophosphate catabolic process 1 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 1 Informative Inherited
Biological Process (BP) dephosphorylation 0.8548 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.001019 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.03509 Informative Inherited
Biological Process (BP) regulation of growth 0.6085 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.4533 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.8203 Informative Inherited
Biological Process (BP) positive regulation of developmental process 1 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.1274 Informative Inherited
Biological Process (BP) single-organism intracellular transport 1 Informative Inherited
Biological Process (BP) protein transport 1 Informative Inherited
Biological Process (BP) regulation of immune response 0.8292 Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.002538 Informative Inherited
Biological Process (BP) proteolysis 0.01614 Informative Inherited
Biological Process (BP) response to nutrient levels 0.001384 Informative Inherited
Biological Process (BP) generation of neurons 0.3266 Informative Inherited
Biological Process (BP) sensory organ development 0.1177 Informative Inherited
Biological Process (BP) cell projection organization 0.9088 Informative Inherited
Biological Process (BP) organelle assembly 0.7294 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) cellular component morphogenesis 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.01573 Informative Inherited
Biological Process (BP) cellular biogenic amine metabolic process 1 Informative Inherited
Biological Process (BP) tube development 0.9176 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 1 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.7566 Informative Inherited
Biological Process (BP) positive regulation of intracellular signal transduction 0.7305 Informative Inherited
Biological Process (BP) secondary metabolic process 0.9517 Informative Inherited
Biological Process (BP) immune effector process 0.01692 Informative Inherited
Biological Process (BP) pigment metabolic process 0.4876 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.5234 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.007784 Informative Inherited
Biological Process (BP) cell proliferation 0.7474 Informative Inherited
Biological Process (BP) regulation of cell cycle process 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.01711 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.004246 Informative Inherited
Biological Process (BP) actin filament-based process 0.02614 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.1164 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.002371 Informative Inherited
Biological Process (BP) chromosome organization 1 Informative Inherited
Biological Process (BP) protein modification by small protein conjugation or removal 0.008656 Informative Inherited
Biological Process (BP) central nervous system development 0.001249 Informative Inherited
Biological Process (BP) lipid localization 0.0356 Informative Inherited
Biological Process (BP) nitrogen compound transport 1 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.7731 Informative Inherited
Biological Process (BP) regulation of ion transport 1 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.001309 Informative Inherited
Biological Process (BP) cellular component movement 0.2676 Informative Inherited
Biological Process (BP) localization of cell 1 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) regulation of system process 0.2307 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.5437 Informative Inherited
Biological Process (BP) regulation of hormone levels 1 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.06097 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.01009 Informative Inherited
Biological Process (BP) muscle structure development 1 Informative Inherited
Biological Process (BP) gland development 0.2 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) sexual reproduction 1 Informative Inherited
Biological Process (BP) protein localization to organelle 0.4612 Informative Inherited
Biological Process (BP) single-organism cellular localization 1 Informative Inherited
Biological Process (BP) phosphorylation 0.648 Informative Inherited
Biological Process (BP) blood circulation 0.1024 Informative Inherited
Biological Process (BP) regulation of immune effector process 1 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.00556 Informative Inherited
Biological Process (BP) cell division 0.8427 Informative Inherited
Biological Process (BP) cell cycle process 1 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.7882 Informative Inherited
Biological Process (BP) inositol phosphate metabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of exocytosis 0 Highly Informative Direct
Biological Process (BP) establishment of synaptic vesicle localization 0 Highly Informative Direct
Biological Process (BP) neurotransmitter transport 0 Highly Informative Direct
Biological Process (BP) regulation of synaptic transmission 0 Highly Informative Direct
Biological Process (BP) exocytosis 0 Highly Informative Direct
Biological Process (BP) regulation of neurotransmitter levels 0 Highly Informative Direct
Biological Process (BP) signal release 0 Highly Informative Direct
Biological Process (BP) phosphatidylinositol metabolic process 0.000000000000001913 Highly Informative Direct
Biological Process (BP) protein ubiquitination 0.000000000001096 Highly Informative Direct
Biological Process (BP) regulation of cellular response to insulin stimulus 0.00000000001186 Highly Informative Direct
Biological Process (BP) ubiquitin-dependent protein catabolic process 0.000000001074 Highly Informative Direct
Biological Process (BP) glycerophospholipid biosynthetic process 0.000000006745 Highly Informative Direct
Biological Process (BP) response to peptide hormone 0.00000003007 Highly Informative Direct
Biological Process (BP) negative regulation of homeostatic process 0.0000003348 Highly Informative Direct
Biological Process (BP) response to calcium ion 0.000001132 Highly Informative Direct
Biological Process (BP) cellular calcium ion homeostasis 0.000002139 Highly Informative Direct
Biological Process (BP) regulation of myeloid leukocyte mediated immunity 0.000006234 Highly Informative Direct
Biological Process (BP) calcium ion transport 0.000006747 Highly Informative Direct
Biological Process (BP) B cell activation 0.0000129 Highly Informative Direct
Biological Process (BP) regulation of protein complex assembly 0.000021 Highly Informative Direct
Biological Process (BP) vesicle organization 0.00004398 Highly Informative Direct
Biological Process (BP) coagulation 0.00004761 Highly Informative Direct
Biological Process (BP) hormone transport 0.00005965 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 0.00007482 Highly Informative Direct
Biological Process (BP) cytokinesis 0.00009804 Highly Informative Direct
Biological Process (BP) icosanoid metabolic process 0.0001003 Highly Informative Direct
Biological Process (BP) plasma membrane organization 0.0001092 Highly Informative Direct
Biological Process (BP) leukocyte homeostasis 0.0001323 Highly Informative Direct
Biological Process (BP) immune response-regulating cell surface receptor signaling pathway 0.0001487 Highly Informative Direct
Biological Process (BP) negative regulation of neuron death 0.0001623 Highly Informative Direct
Biological Process (BP) protein phosphorylation 0.0001789 Highly Informative Direct
Biological Process (BP) regulation of membrane potential 0.0002123 Highly Informative Direct
Biological Process (BP) immune response-activating signal transduction 0.0003198 Highly Informative Direct
Biological Process (BP) regulation of G-protein coupled receptor protein signaling pathway 0.0005834 Highly Informative Direct
Biological Process (BP) positive regulation of angiogenesis 0.0006087 Highly Informative Direct
Biological Process (BP) fatty acid derivative biosynthetic process 0.000609 Highly Informative Direct
Biological Process (BP) positive regulation of cellular component biogenesis 0.002222 Highly Informative Inherited
Biological Process (BP) regulation of proteolysis involved in cellular protein catabolic process 0.05027 Highly Informative Inherited
Biological Process (BP) negative regulation of leukocyte activation 0.08778 Highly Informative Inherited
Biological Process (BP) response to toxic substance 0.2586 Highly Informative Inherited
Biological Process (BP) regulation of wound healing 0.001839 Highly Informative Inherited
Biological Process (BP) regulation of peptide transport 0.2455 Highly Informative Inherited
Biological Process (BP) regulation of organ morphogenesis 0.3427 Highly Informative Inherited
Biological Process (BP) cellular component disassembly 0.1196 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 0.01201 Highly Informative Inherited
Biological Process (BP) negative regulation of nervous system development 0.02956 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0.5084 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.9839 Highly Informative Inherited
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 0.3603 Highly Informative Inherited
Biological Process (BP) regulation of ion homeostasis 0.004433 Highly Informative Inherited
Biological Process (BP) sensory perception 1 Highly Informative Inherited
Biological Process (BP) negative regulation of response to wounding 0.02068 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 0.03367 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.4389 Highly Informative Inherited
Biological Process (BP) alcohol catabolic process 0.02856 Highly Informative Inherited
Biological Process (BP) lipid modification 0.003303 Highly Informative Inherited
Biological Process (BP) multi-organism cellular process 0.3241 Highly Informative Inherited
Biological Process (BP) regulation of cell size 1 Highly Informative Inherited
Biological Process (BP) regulation of blood pressure 1 Highly Informative Inherited
Biological Process (BP) regulation of myeloid cell differentiation 0.004159 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 0.03178 Highly Informative Inherited
Biological Process (BP) response to alcohol 0.3924 Highly Informative Inherited
Biological Process (BP) regulation of neuron apoptotic process 0.002151 Highly Informative Inherited
Biological Process (BP) negative regulation of immune response 1 Highly Informative Inherited
Biological Process (BP) negative regulation of secretion by cell 0.191 Highly Informative Inherited
Biological Process (BP) cilium organization 0.001113 Highly Informative Inherited
Biological Process (BP) cell projection assembly 0.05622 Highly Informative Inherited
Biological Process (BP) cellular component assembly involved in morphogenesis 0.3201 Highly Informative Inherited
Biological Process (BP) cell projection morphogenesis 0.9373 Highly Informative Inherited
Biological Process (BP) regulation of multicellular organism growth 0.02151 Highly Informative Inherited
Biological Process (BP) cellular response to peptide 0.003143 Highly Informative Inherited
Biological Process (BP) ethanolamine-containing compound metabolic process 0.002508 Highly Informative Inherited
Biological Process (BP) regulation of hormone secretion 0.02753 Highly Informative Inherited
Biological Process (BP) positive regulation of homeostatic process 0.07744 Highly Informative Inherited
Biological Process (BP) protein dephosphorylation 0.3552 Highly Informative Inherited
Biological Process (BP) phenol-containing compound metabolic process 0.02374 Highly Informative Inherited
Biological Process (BP) innate immune response 0.01719 Highly Informative Inherited
Biological Process (BP) leukocyte proliferation 0.00528 Highly Informative Inherited
Biological Process (BP) positive regulation of cell division 0.002887 Highly Informative Inherited
Biological Process (BP) positive regulation of cell cycle process 0.007655 Highly Informative Inherited
Biological Process (BP) regulation of multi-organism process 0.2274 Highly Informative Inherited
Biological Process (BP) positive regulation of response to external stimulus 0.935 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.002436 Highly Informative Inherited
Biological Process (BP) neuron projection development 1 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.01058 Highly Informative Inherited
Biological Process (BP) regulation of actin cytoskeleton organization 0.002654 Highly Informative Inherited
Biological Process (BP) actin filament organization 0.1019 Highly Informative Inherited
Biological Process (BP) protein polymerization 0.864 Highly Informative Inherited
Biological Process (BP) maintenance of location 0.8947 Highly Informative Inherited
Biological Process (BP) histone modification 0.8475 Highly Informative Inherited
Biological Process (BP) monocarboxylic acid transport 0.03929 Highly Informative Inherited
Biological Process (BP) amide transport 0.0117 Highly Informative Inherited
Biological Process (BP) response to alkaloid 0.488 Highly Informative Inherited
Biological Process (BP) positive regulation of cell migration 0.4205 Highly Informative Inherited
Biological Process (BP) regulation of muscle system process 0.007177 Highly Informative Inherited
Biological Process (BP) respiratory system development 0.3229 Highly Informative Inherited
Biological Process (BP) cell fate commitment 1 Highly Informative Inherited
Biological Process (BP) fertilization 0.00309 Highly Informative Inherited
Biological Process (BP) regulation of phospholipase activity 0.2425 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.001724 Highly Informative Inherited
Biological Process (BP) organelle fusion 0.001043 Highly Informative Inherited
Biological Process (BP) membrane fusion 0.01396 Highly Informative Inherited
Biological Process (BP) mesenchyme development 0.5144 Highly Informative Inherited
Biological Process (BP) negative regulation of immune effector process 0.2345 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.8375 Highly Informative Inherited
Biological Process (BP) wound healing 0.001274 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 0.005391 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) transferase activity 0.000000002822 Least Informative Direct
Molecular Function (MF) hydrolase activity 0.05248 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 0.000000000298 Moderately Informative Direct
Molecular Function (MF) anion binding 0.0000000003008 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.000000009448 Moderately Informative Direct
Molecular Function (MF) small molecule binding 1 Moderately Informative Inherited
Molecular Function (MF) cation binding 0.673 Moderately Informative Inherited
Molecular Function (MF) lyase activity 1 Moderately Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 1 Moderately Informative Inherited
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) lipid binding 0 Informative Direct
Molecular Function (MF) enzyme activator activity 0.0000000000003401 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.0000000005856 Informative Direct
Molecular Function (MF) enzyme binding 0.0001828 Informative Direct
Molecular Function (MF) receptor binding 0.2454 Informative Inherited
Molecular Function (MF) amide binding 0.8024 Informative Inherited
Molecular Function (MF) carboxylic acid binding 0.7135 Informative Inherited
Molecular Function (MF) phosphatase activity 1 Informative Inherited
Molecular Function (MF) carbon-carbon lyase activity 0.1038 Informative Inherited
Molecular Function (MF) molecular transducer activity 1 Informative Inherited
Molecular Function (MF) receptor activity 1 Informative Inherited
Molecular Function (MF) nucleic acid binding transcription factor activity 1 Informative Inherited
Molecular Function (MF) calcium ion binding 0 Highly Informative Direct
Molecular Function (MF) lipase activity 0 Highly Informative Direct
Molecular Function (MF) Ras GTPase binding 0.000000000000006187 Highly Informative Direct
Molecular Function (MF) phosphoric diester hydrolase activity 0.00000000000002233 Highly Informative Direct
Molecular Function (MF) ubiquitin-protein transferase activity 0.0000000008613 Highly Informative Direct
Molecular Function (MF) amino acid binding 0.000000005103 Highly Informative Direct
Molecular Function (MF) channel regulator activity 0.000000007414 Highly Informative Direct
Molecular Function (MF) GTPase activator activity 0.0000001093 Highly Informative Direct
Molecular Function (MF) alcohol binding 0.00000805 Highly Informative Direct
Molecular Function (MF) hormone binding 0.03413 Highly Informative Inherited
Molecular Function (MF) transcription factor binding transcription factor activity 0.05285 Highly Informative Inherited
Molecular Function (MF) protein domain specific binding 0.02937 Highly Informative Inherited
Molecular Function (MF) peptide binding 0.2199 Highly Informative Inherited
Molecular Function (MF) phosphatidylinositol binding 1 Highly Informative Inherited
Molecular Function (MF) phosphoprotein phosphatase activity 1 Highly Informative Inherited
Molecular Function (MF) protein kinase activity 1 Highly Informative Inherited
Molecular Function (MF) carboxy-lyase activity 0.006349 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) vesicle 0 Moderately Informative Direct
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) cytosol 0.0001817 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.7488 Moderately Informative Inherited
Cellular Component (CC) intrinsic component of membrane 1 Moderately Informative Inherited
Cellular Component (CC) bounding membrane of organelle 0.01228 Moderately Informative Inherited
Cellular Component (CC) plasma membrane part 0.001593 Moderately Informative Inherited
Cellular Component (CC) transferase complex 0.005083 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.04472 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.08976 Moderately Informative Inherited
Cellular Component (CC) synapse 0 Informative Direct
Cellular Component (CC) cell leading edge 0.000000001321 Informative Direct
Cellular Component (CC) cell junction 0.000004817 Informative Direct
Cellular Component (CC) secretory granule 0.00009615 Informative Direct
Cellular Component (CC) extracellular membrane-bounded organelle 0.0001867 Informative Direct
Cellular Component (CC) cell surface 1 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) ciliary part 0.00000176 Highly Informative Direct
Cellular Component (CC) midbody 0.00004182 Highly Informative Direct
Cellular Component (CC) symplast 0.000118 Highly Informative Direct
Cellular Component (CC) cell division site part 0.000795 Highly Informative Direct
Cellular Component (CC) cell body 0.03334 Highly Informative Inherited
Cellular Component (CC) microtubule organizing center 0.04815 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases1Moderately InformativeInherited
Enzyme Commission (EC)Carboxylic ester hydrolases1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0.005268Moderately InformativeInherited
Enzyme Commission (EC)Phosphoinositide phospholipase C0InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol 3-kinase0Highly InformativeDirect
Enzyme Commission (EC)Phospholipase A(2)0Highly InformativeDirect
Enzyme Commission (EC)Protein kinase C0Highly InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-4,5-bisphosphate 3-kinase0Highly InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-4-phosphate 3-kinase2.368e-16Highly InformativeDirect
Enzyme Commission (EC)Lysophospholipase0.000000000002869Highly InformativeDirect
Enzyme Commission (EC)Phospholipase D0.0002652Highly InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.1168Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.3144Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.9002Least InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell physiology0.03857Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell-mediated immunity0.1674Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal adaptive immunity0.1926Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune cell physiology0.2493Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood coagulation0.04355InformativeInherited
Mammalian Phenotype (MP)abnormal ion homeostasis0.06074InformativeInherited
Mammalian Phenotype (MP)abnormal bone marrow cell morphology/development0.08384InformativeInherited
Mammalian Phenotype (MP)abnormal T cell physiology0.8382InformativeInherited
Mammalian Phenotype (MP)abnormal megakaryocyte morphology0.002745Highly InformativeInherited
Mammalian Phenotype (MP)abnormal calcium ion homeostasis0.04172Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cytotoxic T cell physiology0.3475Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.0000211Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.00003817Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.01308Least InformativeInherited
Worm Phenotype (WP)growth variant0.6313Least InformativeInherited
Worm Phenotype (WP)organ system development variant0.0004822Moderately InformativeDirect
Worm Phenotype (WP)chemical response variant0.01064Moderately InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.01341Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.01671Moderately InformativeInherited
Worm Phenotype (WP)germ cell morphology variant0.1438Moderately InformativeInherited
Worm Phenotype (WP)locomotion variant0.168Moderately InformativeInherited
Worm Phenotype (WP)protein expression variant0.0000006343InformativeDirect
Worm Phenotype (WP)organism pathogen response variant0.00001125InformativeDirect
Worm Phenotype (WP)locomotor coordination variant0.0002363InformativeDirect
Worm Phenotype (WP)cell stress response variant0.0002532InformativeDirect
Worm Phenotype (WP)electrophysiology variant0.0003982InformativeDirect
Worm Phenotype (WP)body wall muscle morphology variant0.0006182InformativeDirect
Worm Phenotype (WP)drug resistant0.005929InformativeInherited
Worm Phenotype (WP)copulation variant0.02844InformativeInherited
Worm Phenotype (WP)protein metabolism variant0.1041InformativeInherited
Worm Phenotype (WP)body length variant0.3511InformativeInherited
Worm Phenotype (WP)body width variant0.4921InformativeInherited
Worm Phenotype (WP)male behavior variant1InformativeInherited
Worm Phenotype (WP)protein subcellular localization variant0.00000000006054Highly InformativeDirect
Worm Phenotype (WP)drug induced gene expression variant0.000000001099Highly InformativeDirect
Worm Phenotype (WP)gonad sheath contractions variant0.000000001413Highly InformativeDirect
Worm Phenotype (WP)aldicarb resistant0.00000006339Highly InformativeDirect
Worm Phenotype (WP)endomitotic oocytes0.00000008222Highly InformativeDirect
Worm Phenotype (WP)response to injury variant0.0000002093Highly InformativeDirect
Worm Phenotype (WP)osmotic stress response variant0.000003224Highly InformativeDirect
Worm Phenotype (WP)pharyngeal pumping variant0.00001751Highly InformativeDirect
Worm Phenotype (WP)protein degradation variant0.0000201Highly InformativeDirect
Worm Phenotype (WP)growth rate variant0.00002173Highly InformativeDirect
Worm Phenotype (WP)roller0.00002202Highly InformativeDirect
Worm Phenotype (WP)ovulation variant0.00003503Highly InformativeDirect
Worm Phenotype (WP)post hermaphrodite contact variant0.0001156Highly InformativeDirect
Worm Phenotype (WP)male mating defective0.0001307Highly InformativeDirect
Worm Phenotype (WP)defecation contraction variant0.0001598Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0.1584Least InformativeInherited
Yeast Phenotype (YP)ionic stress resistance0.000858Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)neurophysiology defective0.0007843InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0.605Least InformativeInherited
Zebrafish Anatomy (ZA)immune system0.3391Moderately InformativeInherited
Zebrafish Anatomy (ZA)granulocyte0.0006323InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)pollen tube cell0.00007056InformativeDirect
Plant structure DEvelopment stage (PDE)pollen development stage0.00003891Moderately InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0.008434Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases1Moderately InformativeInherited
Enzyme Commission (EC)Carbon-carbon lyases1Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric diester hydrolases0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0.0009499InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0.1922InformativeInherited
Enzyme Commission (EC)Carboxy-lyases0.6845InformativeInherited
Enzyme Commission (EC)Carboxylic ester hydrolases1InformativeInherited
Enzyme Commission (EC)Phosphatidylinositol-4-phosphate 3-kinase0Highly InformativeDirect
Enzyme Commission (EC)Protein kinase C0Highly InformativeDirect
Enzyme Commission (EC)Phosphoinositide phospholipase C0Highly InformativeDirect
Enzyme Commission (EC)Lysophospholipase0.000000000000914Highly InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0.0003524Highly InformativeDirect

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)nervous system0.346Least InformativeInherited
Drugbank ATC_code (DB)other analgesics and antipyretics0.01049Moderately InformativeInherited
Drugbank ATC_code (DB)psychoanaleptics0.0581Moderately InformativeInherited
Drugbank ATC_code (DB)hormone antagonists and related agents0.0000000001676InformativeDirect
Drugbank ATC_code (DB)paracetamol0.0003418InformativeDirect
Drugbank ATC_code (DB)xanthine derivatives0.0003418InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processApoptosis0Moderately InformativeDirect
Biological processLipid metabolism0Moderately InformativeDirect
Biological processCell cycle0.0005755Moderately InformativeDirect
Biological processEndocytosis0InformativeDirect
Biological processInflammatory response0InformativeDirect
Biological processUbl conjugation pathway0InformativeDirect
Biological processAngiogenesis0.00000000000001047InformativeDirect
Biological processCell adhesion0.0000000006218InformativeDirect
Biological processLipid transport0.000000001253InformativeDirect
Biological processChemotaxis0.00001176InformativeDirect
Biological processNeurogenesis0.0006266InformativeDirect
Biological processSensory transduction0.03329InformativeInherited
Biological processAutophagy0Highly InformativeDirect
Biological processExocytosis0Highly InformativeDirect
Biological processLipid degradation0Highly InformativeDirect
Biological processNeurotransmitter transport9.345e-16Highly InformativeDirect
Biological processFertilization0.0000000002406Highly InformativeDirect
Biological processCilium biogenesis/degradation0.00001516Highly InformativeDirect
Biological processVision0.000055Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentNucleus0.000001283Least InformativeDirect
Cellular componentCytoplasm0.08334Least InformativeInherited
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentEndosome0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0.0000000004307Moderately InformativeDirect
Cellular componentCytoskeleton0.00000003695Moderately InformativeDirect
Cellular componentGolgi apparatus0.0002227Moderately InformativeDirect
Cellular componentSynapse0.0000000006914InformativeDirect
Cellular componentLysosome0.0000004395InformativeDirect
Coding sequence diversityAlternative splicing0.00000000963Least InformativeDirect
DiseaseTumor suppressor0.0008903Moderately InformativeDirect
DomainRepeat0Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainCoiled coil0.000000000002174Moderately InformativeDirect
DomainZinc-finger0.00000000006879Moderately InformativeDirect
DomainSH2 domain0.000000000007608InformativeDirect
DomainSH3 domain0.00007045InformativeDirect
DomainSignal-anchor0.0002497InformativeDirect
DomainSH3-binding0.0003847InformativeDirect
Molecular functionZinc0.000000001658Least InformativeDirect
Molecular functionMetal-binding0.000000002091Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionLipid-binding0InformativeDirect
Post-translational modificationHydrolase0.0000003839Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationGTPase activation0InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0InformativeDirect
Post-translational modificationTransducer0InformativeDirect
Post-translational modificationProtein phosphatase0.00000000001845InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor0.000000002246InformativeDirect
Post-translational modificationChromatin regulator0.0001337InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation0.00003084Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)lipid metabolism0.01104Least InformativeInherited
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect
UniPathway (UP)phospholipid metabolism0.000000000000003565InformativeDirect
UniPathway (UP)biological regulation0Highly InformativeDirect
UniPathway (UP)phosphatidylinositol phosphate biosynthesis0.000000000007582Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR008973 SSF49562 Protein matches
Abstract

The Ca2+-dependent, lipid-binding domain (CaLB) has been identified in a number of proteins, for example the amino-terminal, 138 amino acid C2 domain of cytosolic phospholipase A2 (cPLA2-C2) which mediates an initial step in the production of lipid mediators of inflammation: the Ca2+-dependent translocation of the enzyme to intracellular membranes with subsequent liberation of arachidonic acid. The domain is composed of eight antiparallel beta-strands with six interconnecting loops that fits the "type II" topology for C2 domains. The structure has been identified as a beta-sandwich in the "Greek key" motif [PubMed9665851].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 25 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a C2 domain (Calcium/lipid-binding domain, CaLB) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 25 hidden Markov models representing the C2 domain (Calcium/lipid-binding domain, CaLB) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]