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C2 domain (Calcium/lipid-binding domain, CaLB) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   C2 domain-like [ 49561] (5)
Superfamily:   C2 domain (Calcium/lipid-binding domain, CaLB) [ 49562] (2)
Families:   PLC-like (P variant) [ 49563] (11)
  Synaptotagmin-like (S variant) [ 49575] (10)


Superfamily statistics
Genomes (514) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 47,971 104,903 37
Proteins 31,885 71,197 35


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biological regulation0.013270Least InformativeInherited
Biological Process (BP)regulation of cell communication0.0000046610Moderately InformativeDirect
Biological Process (BP)regulation of signaling0.000072150Moderately InformativeDirect
Biological Process (BP)regulation of response to stimulus0.00048480.0000000000342Moderately InformativeDirect
Biological Process (BP)regulation of molecular function0.0000070840.2326Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.038010.3483Moderately InformativeInherited
Biological Process (BP)positive regulation of catalytic activity0.000000008530.1853InformativeInherited
Biological Process (BP)regulation of hydrolase activity0.0000000050730.3007InformativeInherited
Biological Process (BP)positive regulation of signal transduction0.0082050.226InformativeInherited
Biological Process (BP)regulation of GTPase activity0.000000000000061980.000003048Highly InformativeDirect
Biological Process (BP)positive regulation of hydrolase activity0.000000000064950.007885Highly InformativeInherited
Molecular Function (MF)binding0.20590.000000002934Least InformativeInherited
Molecular Function (MF)molecular function regulator0.00000032640.00000000001308Moderately InformativeDirect
Molecular Function (MF)anion binding0.00004178.27e-16Moderately InformativeDirect
Molecular Function (MF)enzyme activator activity0.000000000067540.000000000002013InformativeDirect
Molecular Function (MF)phospholipid binding0.00000000055750InformativeDirect
Molecular Function (MF)GTPase regulator activity0.000000000000023270Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.000000000000003734 Least Informative Direct
Biological Process (BP) response to stimulus 0.00000003268 Least Informative Direct
Biological Process (BP) primary metabolic process 0.8614 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.9359 Least Informative Inherited
Biological Process (BP) regulation of cell communication 0 Moderately Informative Direct
Biological Process (BP) regulation of signaling 0 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0.0000000000342 Moderately Informative Direct
Biological Process (BP) cellular localization 0 Moderately Informative Direct
Biological Process (BP) single organism signaling 0 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0 Moderately Informative Direct
Biological Process (BP) cell communication 0 Moderately Informative Direct
Biological Process (BP) regulation of localization 0 Moderately Informative Direct
Biological Process (BP) lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) single-organism transport 0 Moderately Informative Direct
Biological Process (BP) organophosphate biosynthetic process 0.0000000000002603 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.00000000006466 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.00000003461 Moderately Informative Direct
Biological Process (BP) immune system process 0.0000712 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.0007042 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.0008471 Moderately Informative Direct
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.5314 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.8466 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.002221 Moderately Informative Inherited
Biological Process (BP) reproduction 0.001884 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.006906 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.0133 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.2326 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.7783 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.002827 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.14 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) defense response 1 Moderately Informative Inherited
Biological Process (BP) nitrogen compound transport 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) protein complex biogenesis 0.01385 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.2975 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.3483 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) animal organ development 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.8159 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) secretion by cell 0 Informative Direct
Biological Process (BP) phospholipid metabolic process 0 Informative Direct
Biological Process (BP) single-organism cellular localization 0 Informative Direct
Biological Process (BP) organelle localization 0 Informative Direct
Biological Process (BP) vesicle-mediated transport 0 Informative Direct
Biological Process (BP) glycerolipid metabolic process 0 Informative Direct
Biological Process (BP) intracellular transport 0.00000000000002769 Informative Direct
Biological Process (BP) single-organism membrane organization 0.0000000000244 Informative Direct
Biological Process (BP) response to wounding 0.0000000005365 Informative Direct
Biological Process (BP) cellular protein complex assembly 0.0000000006796 Informative Direct
Biological Process (BP) cell activation 0.000000001701 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.000000008211 Informative Direct
Biological Process (BP) regulation of catabolic process 0.00000004046 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.0000001125 Informative Direct
Biological Process (BP) locomotion 0.000001612 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.000001772 Informative Direct
Biological Process (BP) alcohol metabolic process 0.000003083 Informative Direct
Biological Process (BP) negative regulation of transport 0.000006054 Informative Direct
Biological Process (BP) regulation of growth 0.00001783 Informative Direct
Biological Process (BP) regulation of locomotion 0.00001927 Informative Direct
Biological Process (BP) positive regulation of transport 0.00002153 Informative Direct
Biological Process (BP) immune effector process 0.00003733 Informative Direct
Biological Process (BP) regulation of protein modification process 0.00006168 Informative Direct
Biological Process (BP) response to nitrogen compound 0.0001523 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.0001536 Informative Direct
Biological Process (BP) regulation of secretion 0.0003445 Informative Direct
Biological Process (BP) negative regulation of cell death 0.0004065 Informative Direct
Biological Process (BP) regulation of nervous system development 0.0005586 Informative Direct
Biological Process (BP) cation homeostasis 0.0005847 Informative Direct
Biological Process (BP) inorganic ion homeostasis 0.0007563 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0.0008073 Informative Direct
Biological Process (BP) negative regulation of signaling 0.0009735 Informative Direct
Biological Process (BP) regulation of cell differentiation 0.04953 Informative Inherited
Biological Process (BP) negative regulation of cellular protein metabolic process 0.0589 Informative Inherited
Biological Process (BP) regulation of proteolysis 0.4981 Informative Inherited
Biological Process (BP) cellular response to inorganic substance 0.1056 Informative Inherited
Biological Process (BP) metal ion transport 0.07897 Informative Inherited
Biological Process (BP) transmembrane transport 1 Informative Inherited
Biological Process (BP) hemopoiesis 0.2799 Informative Inherited
Biological Process (BP) response to metal ion 0.1696 Informative Inherited
Biological Process (BP) regulation of protein localization 1 Informative Inherited
Biological Process (BP) regulation of peptide transport 1 Informative Inherited
Biological Process (BP) system process 0.05586 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 0.2448 Informative Inherited
Biological Process (BP) regulation of immune response 0.6036 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.3256 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.1562 Informative Inherited
Biological Process (BP) generation of neurons 0.004596 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.05774 Informative Inherited
Biological Process (BP) cell development 0.4598 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.853 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.002282 Informative Inherited
Biological Process (BP) regulation of phosphorylation 0.5259 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.1853 Informative Inherited
Biological Process (BP) protein localization to organelle 0.4573 Informative Inherited
Biological Process (BP) proteolysis 0.4761 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 0.3007 Informative Inherited
Biological Process (BP) cellular response to hormone stimulus 0.006223 Informative Inherited
Biological Process (BP) ammonium ion metabolic process 0.05812 Informative Inherited
Biological Process (BP) chromosome organization 1 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.1783 Informative Inherited
Biological Process (BP) regulation of cell proliferation 1 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.226 Informative Inherited
Biological Process (BP) immune response 0.1056 Informative Inherited
Biological Process (BP) pigment metabolic process 0.3505 Informative Inherited
Biological Process (BP) secondary metabolic process 0.8007 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.4795 Informative Inherited
Biological Process (BP) regulation of cell cycle 0.7633 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.002162 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.00332 Informative Inherited
Biological Process (BP) actin cytoskeleton organization 0.02124 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.9734 Informative Inherited
Biological Process (BP) single organism reproductive process 0.8974 Informative Inherited
Biological Process (BP) multi-organism reproductive process 0.003116 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.9395 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.09669 Informative Inherited
Biological Process (BP) protein transport 0.117 Informative Inherited
Biological Process (BP) regulation of hormone levels 1 Informative Inherited
Biological Process (BP) supramolecular fiber organization 0.4102 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.598 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 0.02874 Informative Inherited
Biological Process (BP) lipid localization 0.2058 Informative Inherited
Biological Process (BP) phosphorylation 0.9951 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.9127 Informative Inherited
Biological Process (BP) central nervous system development 0.9986 Informative Inherited
Biological Process (BP) response to temperature stimulus 0.03139 Informative Inherited
Biological Process (BP) regulation of system process 0.9379 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.9671 Informative Inherited
Biological Process (BP) movement of cell or subcellular component 0.9738 Informative Inherited
Biological Process (BP) localization of cell 1 Informative Inherited
Biological Process (BP) response to extracellular stimulus 0.1711 Informative Inherited
Biological Process (BP) post-embryonic development 0.4088 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 0.01374 Informative Inherited
Biological Process (BP) microtubule-based process 0.9133 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.1056 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.002775 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.002928 Informative Inherited
Biological Process (BP) epithelium development 0.4105 Informative Inherited
Biological Process (BP) regulation of cellular localization 0.3812 Informative Inherited
Biological Process (BP) organelle assembly 1 Informative Inherited
Biological Process (BP) embryo development 1 Informative Inherited
Biological Process (BP) circulatory system development 0.7099 Informative Inherited
Biological Process (BP) cell cycle process 0.5428 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.9168 Informative Inherited
Biological Process (BP) regulation of GTPase activity 0.000003048 Highly Informative Direct
Biological Process (BP) regulation of neurotransmitter levels 0 Highly Informative Direct
Biological Process (BP) establishment of organelle localization 0 Highly Informative Direct
Biological Process (BP) cell-cell signaling 0 Highly Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 0 Highly Informative Direct
Biological Process (BP) regulation of response to wounding 0.00000000000564 Highly Informative Direct
Biological Process (BP) endomembrane system organization 0.00000000001814 Highly Informative Direct
Biological Process (BP) fertilization 0.00000000002889 Highly Informative Direct
Biological Process (BP) phosphatidylinositol metabolic process 0.00000000003874 Highly Informative Direct
Biological Process (BP) polyol metabolic process 0.0000000001792 Highly Informative Direct
Biological Process (BP) anatomical structure maturation 0.0000000009754 Highly Informative Direct
Biological Process (BP) autophagy 0.000000001084 Highly Informative Direct
Biological Process (BP) cell maturation 0.00000004004 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 0.00000004071 Highly Informative Direct
Biological Process (BP) lipid modification 0.00000004562 Highly Informative Direct
Biological Process (BP) response to peptide hormone 0.00000005002 Highly Informative Direct
Biological Process (BP) regulation of actin polymerization or depolymerization 0.000001105 Highly Informative Direct
Biological Process (BP) cytokinesis 0.000001349 Highly Informative Direct
Biological Process (BP) vasculogenesis 0.000003294 Highly Informative Direct
Biological Process (BP) positive regulation of growth 0.000004507 Highly Informative Direct
Biological Process (BP) negative regulation of homeostatic process 0.00001074 Highly Informative Direct
Biological Process (BP) positive regulation of secretion by cell 0.00003327 Highly Informative Direct
Biological Process (BP) phosphatidylcholine metabolic process 0.0000466 Highly Informative Direct
Biological Process (BP) post-embryonic animal morphogenesis 0.00005418 Highly Informative Direct
Biological Process (BP) cellular response to calcium ion 0.00008508 Highly Informative Direct
Biological Process (BP) coagulation 0.0001311 Highly Informative Direct
Biological Process (BP) regulation of protein catabolic process 0.0001552 Highly Informative Direct
Biological Process (BP) divalent inorganic cation transport 0.0002242 Highly Informative Direct
Biological Process (BP) regeneration 0.000254 Highly Informative Direct
Biological Process (BP) response to nutrient levels 0.0007231 Highly Informative Direct
Biological Process (BP) cellular calcium ion homeostasis 0.0007721 Highly Informative Direct
Biological Process (BP) neuron development 0.0008032 Highly Informative Direct
Biological Process (BP) positive regulation of cellular component biogenesis 0.007717 Highly Informative Inherited
Biological Process (BP) cell projection assembly 0.433 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.5113 Highly Informative Inherited
Biological Process (BP) positive regulation of cell development 0.004471 Highly Informative Inherited
Biological Process (BP) positive regulation of nervous system development 0.01143 Highly Informative Inherited
Biological Process (BP) regulation of cell growth 0.03799 Highly Informative Inherited
Biological Process (BP) inorganic cation transmembrane transport 0.004991 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 0.3142 Highly Informative Inherited
Biological Process (BP) organelle fusion 0.005963 Highly Informative Inherited
Biological Process (BP) single-organism membrane fusion 0.8675 Highly Informative Inherited
Biological Process (BP) cellular component disassembly 0.07944 Highly Informative Inherited
Biological Process (BP) extracellular matrix organization 0.03158 Highly Informative Inherited
Biological Process (BP) response to growth factor 0.09747 Highly Informative Inherited
Biological Process (BP) negative regulation of nervous system development 0.2833 Highly Informative Inherited
Biological Process (BP) regulation of ion homeostasis 0.004002 Highly Informative Inherited
Biological Process (BP) nervous system process 0.2818 Highly Informative Inherited
Biological Process (BP) immune response-activating signal transduction 0.001047 Highly Informative Inherited
Biological Process (BP) negative regulation of cell development 0.3014 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 1 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.4649 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 0.1915 Highly Informative Inherited
Biological Process (BP) spermatogenesis 0.05002 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 0.1033 Highly Informative Inherited
Biological Process (BP) positive regulation of lymphocyte activation 0.263 Highly Informative Inherited
Biological Process (BP) positive regulation of cell adhesion 0.513 Highly Informative Inherited
Biological Process (BP) regulation of cell size 1 Highly Informative Inherited
Biological Process (BP) regulation of hemopoiesis 1 Highly Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.007885 Highly Informative Inherited
Biological Process (BP) negative regulation of apoptotic process 0.04255 Highly Informative Inherited
Biological Process (BP) regulation of neuron apoptotic process 0.0112 Highly Informative Inherited
Biological Process (BP) cellular protein catabolic process 0.004263 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 1 Highly Informative Inherited
Biological Process (BP) lymphocyte activation 0.7017 Highly Informative Inherited
Biological Process (BP) negative regulation of growth 0.5708 Highly Informative Inherited
Biological Process (BP) cellular response to organonitrogen compound 0.003671 Highly Informative Inherited
Biological Process (BP) glycerophospholipid biosynthetic process 0.07796 Highly Informative Inherited
Biological Process (BP) tube morphogenesis 0.8847 Highly Informative Inherited
Biological Process (BP) phenol-containing compound metabolic process 0.095 Highly Informative Inherited
Biological Process (BP) innate immune response 0.5897 Highly Informative Inherited
Biological Process (BP) regulation of cell division 0.1174 Highly Informative Inherited
Biological Process (BP) positive regulation of response to external stimulus 0.9768 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.4722 Highly Informative Inherited
Biological Process (BP) negative regulation of catabolic process 0.001028 Highly Informative Inherited
Biological Process (BP) plasma membrane bounded cell projection organization 0.7856 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.1556 Highly Informative Inherited
Biological Process (BP) regulation of protein polymerization 0.002163 Highly Informative Inherited
Biological Process (BP) germ cell development 0.07173 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.006238 Highly Informative Inherited
Biological Process (BP) protein secretion 1 Highly Informative Inherited
Biological Process (BP) actin filament organization 0.004136 Highly Informative Inherited
Biological Process (BP) protein polymerization 0.5783 Highly Informative Inherited
Biological Process (BP) modification-dependent macromolecule catabolic process 0.001365 Highly Informative Inherited
Biological Process (BP) maintenance of location 0.3536 Highly Informative Inherited
Biological Process (BP) histone modification 0.8572 Highly Informative Inherited
Biological Process (BP) protein modification by small protein conjugation 0.001128 Highly Informative Inherited
Biological Process (BP) response to carbohydrate 0.001156 Highly Informative Inherited
Biological Process (BP) cellular response to extracellular stimulus 0.9063 Highly Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.02643 Highly Informative Inherited
Biological Process (BP) microtubule cytoskeleton organization 1 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.7081 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte migration 0.7655 Highly Informative Inherited
Biological Process (BP) negative regulation of cellular component movement 0.03452 Highly Informative Inherited
Biological Process (BP) negative regulation of locomotion 0.03477 Highly Informative Inherited
Biological Process (BP) epithelial cell differentiation 0.4883 Highly Informative Inherited
Biological Process (BP) phagocytosis 1 Highly Informative Inherited
Biological Process (BP) lysosome organization 0.002018 Highly Informative Inherited
Biological Process (BP) vesicle organization 0.00398 Highly Informative Inherited
Biological Process (BP) wound healing 0.05962 Highly Informative Inherited
Biological Process (BP) sensory organ morphogenesis 0.0535 Highly Informative Inherited
Biological Process (BP) gastrulation 0.09602 Highly Informative Inherited
Molecular Function (MF) binding 0.000000002934 Least Informative Direct
Molecular Function (MF) hydrolase activity 0.000000000000009279 Least Informative Direct
Molecular Function (MF) transferase activity 0.1005 Least Informative Inherited
Molecular Function (MF) molecular function regulator 0.00000000001308 Moderately Informative Direct
Molecular Function (MF) anion binding 8.27e-16 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 0 Moderately Informative Direct
Molecular Function (MF) metal ion binding 0.000000000001667 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.00000000005045 Moderately Informative Direct
Molecular Function (MF) small molecule binding 1 Moderately Informative Inherited
Molecular Function (MF) lyase activity 1 Moderately Informative Inherited
Molecular Function (MF) enzyme activator activity 0.000000000002013 Informative Direct
Molecular Function (MF) phospholipid binding 0 Informative Direct
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.00000000008003 Informative Direct
Molecular Function (MF) enzyme binding 0.00000001131 Informative Direct
Molecular Function (MF) receptor binding 0.004336 Informative Inherited
Molecular Function (MF) phosphatase activity 1 Informative Inherited
Molecular Function (MF) carbon-carbon lyase activity 0.4627 Informative Inherited
Molecular Function (MF) GTPase regulator activity 0 Highly Informative Direct
Molecular Function (MF) calcium ion binding 0 Highly Informative Direct
Molecular Function (MF) phosphoric diester hydrolase activity 0 Highly Informative Direct
Molecular Function (MF) lipase activity 0 Highly Informative Direct
Molecular Function (MF) modified amino acid binding 0.0000000000001809 Highly Informative Direct
Molecular Function (MF) ubiquitin-like protein transferase activity 0.00001963 Highly Informative Direct
Molecular Function (MF) alcohol binding 0.00002838 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0.5246 Highly Informative Inherited
Molecular Function (MF) transcription factor activity, transcription factor binding 0.1124 Highly Informative Inherited
Molecular Function (MF) small GTPase binding 0.3152 Highly Informative Inherited
Molecular Function (MF) phosphatidylinositol phosphate binding 0.3269 Highly Informative Inherited
Molecular Function (MF) guanyl-nucleotide exchange factor activity 1 Highly Informative Inherited
Molecular Function (MF) phosphoprotein phosphatase activity 0.8229 Highly Informative Inherited
Molecular Function (MF) carboxy-lyase activity 0.05955 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) endomembrane system 0 Moderately Informative Direct
Cellular Component (CC) vesicle 0 Moderately Informative Direct
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) extracellular region part 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) intrinsic component of membrane 1 Moderately Informative Inherited
Cellular Component (CC) bounding membrane of organelle 0.5268 Moderately Informative Inherited
Cellular Component (CC) whole membrane 1 Moderately Informative Inherited
Cellular Component (CC) transferase complex 0.03247 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.2858 Moderately Informative Inherited
Cellular Component (CC) extrinsic component of membrane 0 Informative Direct
Cellular Component (CC) cytoplasmic vesicle part 0.00000008566 Informative Direct
Cellular Component (CC) transferase complex, transferring phosphorus-containing groups 0.000199 Informative Direct
Cellular Component (CC) cytoplasmic region 0.000261 Informative Direct
Cellular Component (CC) extracellular organelle 0.0004688 Informative Direct
Cellular Component (CC) side of membrane 0.8911 Informative Inherited
Cellular Component (CC) cell surface 1 Informative Inherited
Cellular Component (CC) extracellular space 0.8418 Informative Inherited
Cellular Component (CC) plasma membrane bounded cell projection part 0.5658 Informative Inherited
Cellular Component (CC) cilium 0.01705 Informative Inherited
Cellular Component (CC) nuclear envelope 0.08192 Informative Inherited
Cellular Component (CC) endoplasmic reticulum membrane 1 Informative Inherited
Cellular Component (CC) secretory granule 0.03696 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 0.0353 Informative Inherited
Cellular Component (CC) presynapse 0 Highly Informative Direct
Cellular Component (CC) exocytic vesicle 0 Highly Informative Direct
Cellular Component (CC) cytoplasmic vesicle membrane 0.0000007329 Highly Informative Direct
Cellular Component (CC) midbody 0.00000329 Highly Informative Direct
Cellular Component (CC) nuclear membrane 0.00001565 Highly Informative Direct
Cellular Component (CC) symplast 0.00001655 Highly Informative Direct
Cellular Component (CC) extracellular exosome 0.00004123 Highly Informative Direct
Cellular Component (CC) cell-substrate adherens junction 0.0000586 Highly Informative Direct
Cellular Component (CC) cell division site part 0.0003767 Highly Informative Direct
Cellular Component (CC) microtubule organizing center 0.0005023 Highly Informative Direct
Cellular Component (CC) endocytic vesicle 1 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases1Moderately InformativeInherited
Enzyme Commission (EC)Carboxylic ester hydrolases1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0.005268Moderately InformativeInherited
Enzyme Commission (EC)Phosphoinositide phospholipase C0InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol 3-kinase0Highly InformativeDirect
Enzyme Commission (EC)Phospholipase A(2)0Highly InformativeDirect
Enzyme Commission (EC)Protein kinase C0Highly InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-4,5-bisphosphate 3-kinase0Highly InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-4-phosphate 3-kinase2.368e-16Highly InformativeDirect
Enzyme Commission (EC)Lysophospholipase0.000000000002869Highly InformativeDirect
Enzyme Commission (EC)Phospholipase D0.0002652Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processDifferentiation0Moderately InformativeDirect
Biological processImmunity0Moderately InformativeDirect
Biological processLipid metabolism0Moderately InformativeDirect
Biological processUbl conjugation pathway2.442e-16Moderately InformativeDirect
Biological processApoptosis4.848e-16Moderately InformativeDirect
Biological processAutophagy0InformativeDirect
Biological processEndocytosis0InformativeDirect
Biological processInflammatory response0InformativeDirect
Biological processLipid degradation0InformativeDirect
Biological processAngiogenesis0.000000000000001917InformativeDirect
Biological processLipid transport0.00000000006895InformativeDirect
Biological processCell adhesion0.000000002131InformativeDirect
Biological processChemotaxis0.00002477InformativeDirect
Biological processPlant defense0.000416InformativeDirect
Biological processSensory transduction0.0434InformativeInherited
Biological processExocytosis0Highly InformativeDirect
Biological processAbscisic acid signaling pathway0Highly InformativeDirect
Biological processNeurotransmitter transport0.00000000000000239Highly InformativeDirect
Biological processFertilization0.0000000008085Highly InformativeDirect
Biological processPhagocytosis0.000000001477Highly InformativeDirect
Biological processGrowth regulation0.000004213Highly InformativeDirect
Biological processVision0.00007827Highly InformativeDirect
Biological processCilium biogenesis/degradation0.0001012Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentNucleus0.000000000126Least InformativeDirect
Cellular componentCytoplasm0.09049Least InformativeInherited
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentEndosome0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0Moderately InformativeDirect
Cellular componentCytoskeleton0.00000000004399Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0.0000000001042Moderately InformativeDirect
Cellular componentGolgi apparatus0.000001998Moderately InformativeDirect
Cellular componentLysosome0.0000000004581InformativeDirect
Cellular componentSynapse0.00000002044InformativeDirect
Coding sequence diversityAlternative splicing0.0000000003276Least InformativeDirect
DiseaseTumor suppressor0.0006261Moderately InformativeDirect
DomainRepeat0Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainCoiled coil0.00000000001701Moderately InformativeDirect
DomainZinc-finger0.0000000002774Moderately InformativeDirect
DomainSH2 domain0.000000000001385InformativeDirect
DomainSH3 domain0.00002826InformativeDirect
DomainSignal-anchor0.00008316InformativeDirect
DomainSH3-binding0.0004101InformativeDirect
Molecular functionMetal-binding0.00000000234Least InformativeDirect
Molecular functionZinc0.0000001248Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionLipid-binding0Moderately InformativeDirect
Post-translational modificationHydrolase0.000006616Least InformativeDirect
Post-translational modificationTransferase0.2031Least InformativeInherited
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0.00001586Moderately InformativeDirect
Post-translational modificationGTPase activation0InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0InformativeDirect
Post-translational modificationProtein phosphatase0.0000000000003165InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor0.0000000003669InformativeDirect
Post-translational modificationChromatin regulator0.0002537InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR008973 SSF49562 Protein matches
Abstract

The Ca2+-dependent, lipid-binding domain (CaLB) has been identified in a number of proteins, for example the amino-terminal, 138 amino acid C2 domain of cytosolic phospholipase A2 (cPLA2-C2) which mediates an initial step in the production of lipid mediators of inflammation: the Ca2+-dependent translocation of the enzyme to intracellular membranes with subsequent liberation of arachidonic acid. The domain is composed of eight antiparallel beta-strands with six interconnecting loops that fits the "type II" topology for C2 domains. The structure has been identified as a beta-sandwich in the "Greek key" motif [PubMed9665851].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 25 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a C2 domain (Calcium/lipid-binding domain, CaLB) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 25 hidden Markov models representing the C2 domain (Calcium/lipid-binding domain, CaLB) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]