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C2 domain (Calcium/lipid-binding domain, CaLB) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   C2 domain-like [ 49561] (5)
Superfamily:   C2 domain (Calcium/lipid-binding domain, CaLB) [ 49562] (2)
Families:   PLC-like (P variant) [ 49563] (11)
  Synaptotagmin-like (S variant) [ 49575] (10)


Superfamily statistics
Genomes (507) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 46,927 45,964 37
Proteins 31,132 30,598 35


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biological regulation0.0049730Least InformativeInherited
Biological Process (BP)regulation of cell communication0.00000041850Moderately InformativeDirect
Biological Process (BP)regulation of signaling0.000095060Moderately InformativeDirect
Biological Process (BP)regulation of response to stimulus0.00063480.0000000002062Moderately InformativeDirect
Biological Process (BP)regulation of molecular function0.0000074960.1246Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.038760.09051Moderately InformativeInherited
Biological Process (BP)regulation of hydrolase activity0.00000000036280.3728InformativeInherited
Biological Process (BP)positive regulation of catalytic activity0.00000000049650.1551InformativeInherited
Biological Process (BP)positive regulation of signal transduction0.0087450.1594InformativeInherited
Biological Process (BP)positive regulation of GTPase activity00.00002553Highly InformativeDirect
Molecular Function (MF)binding0.030410Least InformativeInherited
Molecular Function (MF)molecular function regulator0.00000002390.0000000000001276Moderately InformativeDirect
Molecular Function (MF)anion binding0.0000046030Moderately InformativeDirect
Molecular Function (MF)enzyme activator activity0.0000000000041530.000000000001254InformativeDirect
Molecular Function (MF)phospholipid binding0.000000000062160InformativeDirect
Molecular Function (MF)GTPase regulator activity0.0000000000000027030Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) response to stimulus 0.000000000001178 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.7109 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.3089 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) regulation of cell communication 0 Moderately Informative Direct
Biological Process (BP) regulation of signaling 0 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0.0000000002062 Moderately Informative Direct
Biological Process (BP) lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) cell communication 0 Moderately Informative Direct
Biological Process (BP) regulation of localization 0 Moderately Informative Direct
Biological Process (BP) signaling 0 Moderately Informative Direct
Biological Process (BP) cellular localization 0 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0 Moderately Informative Direct
Biological Process (BP) single-organism transport 0.000000000000003692 Moderately Informative Direct
Biological Process (BP) organophosphate biosynthetic process 0.0000000000001145 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.0000000003429 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.0000000007721 Moderately Informative Direct
Biological Process (BP) immune system process 0.00001399 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.0003216 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.2965 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.1246 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.00159 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.7919 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.01128 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 1 Moderately Informative Inherited
Biological Process (BP) system development 0.2643 Moderately Informative Inherited
Biological Process (BP) reproduction 0.007815 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.006414 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.6821 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.7116 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.09051 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.5241 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.6568 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.9229 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.003402 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) response to stress 1 Moderately Informative Inherited
Biological Process (BP) secretion 0 Informative Direct
Biological Process (BP) single-organism intracellular transport 0 Informative Direct
Biological Process (BP) glycerolipid metabolic process 0 Informative Direct
Biological Process (BP) phospholipid metabolic process 0 Informative Direct
Biological Process (BP) vesicle-mediated transport 0 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.0000000007972 Informative Direct
Biological Process (BP) single-organism membrane organization 0.0000004085 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.0000009734 Informative Direct
Biological Process (BP) alcohol metabolic process 0.000001622 Informative Direct
Biological Process (BP) regulation of protein modification process 0.000001679 Informative Direct
Biological Process (BP) regulation of catabolic process 0.000003046 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.00000672 Informative Direct
Biological Process (BP) response to nitrogen compound 0.00001025 Informative Direct
Biological Process (BP) locomotion 0.00001099 Informative Direct
Biological Process (BP) positive regulation of transport 0.00001353 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0.00002257 Informative Direct
Biological Process (BP) regulation of locomotion 0.00002738 Informative Direct
Biological Process (BP) regulation of growth 0.00002841 Informative Direct
Biological Process (BP) generation of neurons 0.00005445 Informative Direct
Biological Process (BP) cellular chemical homeostasis 0.0000771 Informative Direct
Biological Process (BP) negative regulation of transport 0.00008017 Informative Direct
Biological Process (BP) behavior 0.0002252 Informative Direct
Biological Process (BP) negative regulation of cell death 0.0004594 Informative Direct
Biological Process (BP) cellular macromolecular complex assembly 0.000497 Informative Direct
Biological Process (BP) regulation of secretion 0.000684 Informative Direct
Biological Process (BP) regulation of transmembrane transport 1 Informative Inherited
Biological Process (BP) regulation of ion transport 1 Informative Inherited
Biological Process (BP) regulation of cell differentiation 0.2022 Informative Inherited
Biological Process (BP) negative regulation of cellular protein metabolic process 0.06907 Informative Inherited
Biological Process (BP) regulation of proteolysis 0.3616 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.005405 Informative Inherited
Biological Process (BP) regulation of cellular localization 0.4657 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 0.3728 Informative Inherited
Biological Process (BP) transmembrane transport 1 Informative Inherited
Biological Process (BP) protein localization to organelle 0.4738 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.001752 Informative Inherited
Biological Process (BP) response to inorganic substance 0.004663 Informative Inherited
Biological Process (BP) microtubule-based process 1 Informative Inherited
Biological Process (BP) regulation of transcription, DNA-templated 1 Informative Inherited
Biological Process (BP) regulation of immune response 0.6906 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.5058 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.005509 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.1529 Informative Inherited
Biological Process (BP) cell development 0.9108 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.7429 Informative Inherited
Biological Process (BP) multi-organism reproductive process 0.02609 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.003023 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.004543 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.1416 Informative Inherited
Biological Process (BP) regulation of phosphorylation 0.5391 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.1551 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.001094 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.002267 Informative Inherited
Biological Process (BP) cellular response to hormone stimulus 0.02189 Informative Inherited
Biological Process (BP) cellular modified amino acid metabolic process 0.4095 Informative Inherited
Biological Process (BP) regulation of cell proliferation 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.6981 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.7364 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.1529 Informative Inherited
Biological Process (BP) pigment metabolic process 0.3071 Informative Inherited
Biological Process (BP) secondary metabolic process 0.7664 Informative Inherited
Biological Process (BP) immune response 0.09458 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.5271 Informative Inherited
Biological Process (BP) regulation of cell cycle 0.6003 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.08639 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.1594 Informative Inherited
Biological Process (BP) actin filament-based process 0.02205 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.2194 Informative Inherited
Biological Process (BP) regulation of hormone levels 1 Informative Inherited
Biological Process (BP) nitrogen compound transport 1 Informative Inherited
Biological Process (BP) central nervous system development 0.473 Informative Inherited
Biological Process (BP) proteolysis 0.7523 Informative Inherited
Biological Process (BP) lipid localization 0.2845 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.9554 Informative Inherited
Biological Process (BP) phosphorylation 1 Informative Inherited
Biological Process (BP) response to organic cyclic compound 1 Informative Inherited
Biological Process (BP) movement of cell or subcellular component 0.8768 Informative Inherited
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.3809 Informative Inherited
Biological Process (BP) single organism reproductive process 0.9609 Informative Inherited
Biological Process (BP) ion homeostasis 0.2716 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.002664 Informative Inherited
Biological Process (BP) metal ion transport 0.07667 Informative Inherited
Biological Process (BP) protein targeting 1 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 0.01306 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 0.3728 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.2825 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.00337 Informative Inherited
Biological Process (BP) post-embryonic development 0.3193 Informative Inherited
Biological Process (BP) organelle assembly 0.4565 Informative Inherited
Biological Process (BP) epithelium development 0.2009 Informative Inherited
Biological Process (BP) embryo development 1 Informative Inherited
Biological Process (BP) circulatory system development 0.3349 Informative Inherited
Biological Process (BP) cell cycle process 0.6027 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.7556 Informative Inherited
Biological Process (BP) positive regulation of GTPase activity 0.00002553 Highly Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 0 Highly Informative Direct
Biological Process (BP) vesicle localization 0 Highly Informative Direct
Biological Process (BP) synaptic signaling 0 Highly Informative Direct
Biological Process (BP) regulation of actin filament polymerization 0 Highly Informative Direct
Biological Process (BP) signal release 0 Highly Informative Direct
Biological Process (BP) regulation of neurotransmitter levels 0 Highly Informative Direct
Biological Process (BP) establishment of organelle localization 0 Highly Informative Direct
Biological Process (BP) endomembrane system organization 0.000000000001702 Highly Informative Direct
Biological Process (BP) regulation of response to wounding 0.00000000002022 Highly Informative Direct
Biological Process (BP) phosphatidylinositol metabolic process 0.00000000002649 Highly Informative Direct
Biological Process (BP) polyol metabolic process 0.0000000001327 Highly Informative Direct
Biological Process (BP) autophagy 0.000000001297 Highly Informative Direct
Biological Process (BP) response to peptide hormone 0.00000001305 Highly Informative Direct
Biological Process (BP) response to calcium ion 0.00000001497 Highly Informative Direct
Biological Process (BP) lipid modification 0.00000006108 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 0.00000007647 Highly Informative Direct
Biological Process (BP) protein modification by small protein conjugation 0.000001421 Highly Informative Direct
Biological Process (BP) regulated exocytosis 0.000003396 Highly Informative Direct
Biological Process (BP) negative regulation of homeostatic process 0.000004076 Highly Informative Direct
Biological Process (BP) regulation of sequence-specific DNA binding transcription factor activity 0.000006783 Highly Informative Direct
Biological Process (BP) positive regulation of growth 0.0000107 Highly Informative Direct
Biological Process (BP) divalent inorganic cation transport 0.00002672 Highly Informative Direct
Biological Process (BP) coagulation 0.00003501 Highly Informative Direct
Biological Process (BP) regulation of cation transmembrane transport 0.00004242 Highly Informative Direct
Biological Process (BP) actin filament organization 0.00005349 Highly Informative Direct
Biological Process (BP) leukocyte activation involved in immune response 0.00005444 Highly Informative Direct
Biological Process (BP) regulation of protein catabolic process 0.00005977 Highly Informative Direct
Biological Process (BP) cell maturation 0.00008389 Highly Informative Direct
Biological Process (BP) regeneration 0.00009808 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.0001955 Highly Informative Direct
Biological Process (BP) regulation of ion homeostasis 0.0001972 Highly Informative Direct
Biological Process (BP) negative regulation of catabolic process 0.0002125 Highly Informative Direct
Biological Process (BP) modification-dependent protein catabolic process 0.0002126 Highly Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0.0002424 Highly Informative Direct
Biological Process (BP) response to nutrient levels 0.0003051 Highly Informative Direct
Biological Process (BP) cell junction assembly 0.0003968 Highly Informative Direct
Biological Process (BP) cellular calcium ion homeostasis 0.0004593 Highly Informative Direct
Biological Process (BP) female gamete generation 0.0004961 Highly Informative Direct
Biological Process (BP) inorganic cation transmembrane transport 0.0005056 Highly Informative Direct
Biological Process (BP) response to carbohydrate 0.0007064 Highly Informative Direct
Biological Process (BP) positive regulation of cellular component biogenesis 0.003325 Highly Informative Inherited
Biological Process (BP) regulation of cell growth 0.02623 Highly Informative Inherited
Biological Process (BP) positive regulation of cell development 0.01497 Highly Informative Inherited
Biological Process (BP) positive regulation of nervous system development 0.0285 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.6127 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 0.1399 Highly Informative Inherited
Biological Process (BP) organelle fusion 0.005633 Highly Informative Inherited
Biological Process (BP) single-organism membrane fusion 0.3252 Highly Informative Inherited
Biological Process (BP) extracellular matrix organization 0.04337 Highly Informative Inherited
Biological Process (BP) cellular response to organonitrogen compound 0.02713 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 0.2885 Highly Informative Inherited
Biological Process (BP) cellular response to metal ion 0.1214 Highly Informative Inherited
Biological Process (BP) negative regulation of cell development 0.3004 Highly Informative Inherited
Biological Process (BP) hemopoiesis 0.2826 Highly Informative Inherited
Biological Process (BP) microtubule cytoskeleton organization 1 Highly Informative Inherited
Biological Process (BP) inner ear development 0.001653 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 0.2506 Highly Informative Inherited
Biological Process (BP) germ cell development 0.01351 Highly Informative Inherited
Biological Process (BP) spermatogenesis 0.1186 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 0.06779 Highly Informative Inherited
Biological Process (BP) positive regulation of lymphocyte activation 0.2956 Highly Informative Inherited
Biological Process (BP) positive regulation of cell adhesion 0.4958 Highly Informative Inherited
Biological Process (BP) negative regulation of growth 0.4769 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.6186 Highly Informative Inherited
Biological Process (BP) regulation of cell size 0.9818 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 0.7799 Highly Informative Inherited
Biological Process (BP) regulation of neuron apoptotic process 0.006437 Highly Informative Inherited
Biological Process (BP) endosomal transport 0.2034 Highly Informative Inherited
Biological Process (BP) neuron development 0.007725 Highly Informative Inherited
Biological Process (BP) lymphocyte activation 1 Highly Informative Inherited
Biological Process (BP) ammonium ion metabolic process 0.03239 Highly Informative Inherited
Biological Process (BP) glycerophospholipid biosynthetic process 0.0237 Highly Informative Inherited
Biological Process (BP) tube morphogenesis 0.7227 Highly Informative Inherited
Biological Process (BP) metamorphosis 0.2276 Highly Informative Inherited
Biological Process (BP) instar larval or pupal morphogenesis 1 Highly Informative Inherited
Biological Process (BP) phenol-containing compound metabolic process 0.05612 Highly Informative Inherited
Biological Process (BP) innate immune response 0.5532 Highly Informative Inherited
Biological Process (BP) regulation of cell division 0.08525 Highly Informative Inherited
Biological Process (BP) positive regulation of response to external stimulus 1 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.2853 Highly Informative Inherited
Biological Process (BP) cell projection organization 0.3207 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.08359 Highly Informative Inherited
Biological Process (BP) epithelial cell differentiation 0.1548 Highly Informative Inherited
Biological Process (BP) chemotaxis 0.1729 Highly Informative Inherited
Biological Process (BP) cellular component disassembly 0.001681 Highly Informative Inherited
Biological Process (BP) pattern specification process 1 Highly Informative Inherited
Biological Process (BP) amide transport 0.01226 Highly Informative Inherited
Biological Process (BP) protein secretion 1 Highly Informative Inherited
Biological Process (BP) protein polymerization 0.6575 Highly Informative Inherited
Biological Process (BP) brain development 0.03785 Highly Informative Inherited
Biological Process (BP) histone modification 0.8196 Highly Informative Inherited
Biological Process (BP) cell migration 1 Highly Informative Inherited
Biological Process (BP) cellular response to external stimulus 0.1606 Highly Informative Inherited
Biological Process (BP) muscle structure development 1 Highly Informative Inherited
Biological Process (BP) negative regulation of locomotion 0.08668 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.766 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte migration 0.6463 Highly Informative Inherited
Biological Process (BP) negative regulation of cellular component movement 0.07446 Highly Informative Inherited
Biological Process (BP) myeloid leukocyte activation 0.03904 Highly Informative Inherited
Biological Process (BP) lysosome organization 0.00118 Highly Informative Inherited
Biological Process (BP) vesicle organization 0.004717 Highly Informative Inherited
Biological Process (BP) endocytosis 1 Highly Informative Inherited
Biological Process (BP) wound healing 0.07491 Highly Informative Inherited
Biological Process (BP) sensory organ morphogenesis 0.05263 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 1 Highly Informative Inherited
Biological Process (BP) gastrulation 0.09193 Highly Informative Inherited
Biological Process (BP) cell division 0.03756 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) hydrolase activity 0.000000000001083 Least Informative Direct
Molecular Function (MF) transferase activity 0.07443 Least Informative Inherited
Molecular Function (MF) molecular function regulator 0.0000000000001276 Moderately Informative Direct
Molecular Function (MF) anion binding 0 Moderately Informative Direct
Molecular Function (MF) protein binding 0.000008173 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 0 Moderately Informative Direct
Molecular Function (MF) metal ion binding 0.000000000001701 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.000000001132 Moderately Informative Direct
Molecular Function (MF) small molecule binding 1 Moderately Informative Inherited
Molecular Function (MF) lyase activity 1 Moderately Informative Inherited
Molecular Function (MF) enzyme activator activity 0.000000000001254 Informative Direct
Molecular Function (MF) phospholipid binding 0 Informative Direct
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) phosphoric ester hydrolase activity 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.0000000008791 Informative Direct
Molecular Function (MF) enzyme binding 0.00000008743 Informative Direct
Molecular Function (MF) receptor binding 0.00278 Informative Inherited
Molecular Function (MF) carbon-carbon lyase activity 0.3562 Informative Inherited
Molecular Function (MF) GTPase regulator activity 0 Highly Informative Direct
Molecular Function (MF) phospholipase activity 0 Highly Informative Direct
Molecular Function (MF) calcium ion binding 0 Highly Informative Direct
Molecular Function (MF) phosphoric diester hydrolase activity 0 Highly Informative Direct
Molecular Function (MF) modified amino acid binding 0.0000000000001623 Highly Informative Direct
Molecular Function (MF) ubiquitin-like protein transferase activity 0.000008508 Highly Informative Direct
Molecular Function (MF) alcohol binding 0.00008173 Highly Informative Direct
Molecular Function (MF) small GTPase binding 0.3824 Highly Informative Inherited
Molecular Function (MF) phosphatidylinositol bisphosphate binding 0.006092 Highly Informative Inherited
Molecular Function (MF) guanyl-nucleotide exchange factor activity 1 Highly Informative Inherited
Molecular Function (MF) phosphoprotein phosphatase activity 0.8408 Highly Informative Inherited
Molecular Function (MF) protein kinase activity 0.6955 Highly Informative Inherited
Molecular Function (MF) carboxy-lyase activity 0.0402 Highly Informative Inherited
Molecular Function (MF) transcription factor activity, transcription factor binding 0.05463 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) vesicle 0 Moderately Informative Direct
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.8481 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.06075 Moderately Informative Inherited
Cellular Component (CC) intrinsic component of membrane 1 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.05145 Moderately Informative Inherited
Cellular Component (CC) whole membrane 0.931 Moderately Informative Inherited
Cellular Component (CC) transferase complex 0.02706 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.4308 Moderately Informative Inherited
Cellular Component (CC) secretory vesicle 0 Informative Direct
Cellular Component (CC) extrinsic component of membrane 0 Informative Direct
Cellular Component (CC) transport vesicle 0 Informative Direct
Cellular Component (CC) synapse 0 Informative Direct
Cellular Component (CC) cell projection part 0.00000000003307 Informative Direct
Cellular Component (CC) cytoplasmic vesicle part 0.0000001076 Informative Direct
Cellular Component (CC) extracellular organelle 0.00003664 Informative Direct
Cellular Component (CC) cell junction 0.00005019 Informative Direct
Cellular Component (CC) plasma membrane region 0.0003629 Informative Direct
Cellular Component (CC) side of membrane 1 Informative Inherited
Cellular Component (CC) cell surface 1 Informative Inherited
Cellular Component (CC) cilium 0.01863 Informative Inherited
Cellular Component (CC) endoplasmic reticulum membrane 1 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 0.1097 Informative Inherited
Cellular Component (CC) synaptic vesicle 0 Highly Informative Direct
Cellular Component (CC) cell division site 0.000003225 Highly Informative Direct
Cellular Component (CC) extracellular exosome 0.000009788 Highly Informative Direct
Cellular Component (CC) midbody 0.00001285 Highly Informative Direct
Cellular Component (CC) symplast 0.00004607 Highly Informative Direct
Cellular Component (CC) vesicle membrane 0.0004057 Highly Informative Direct
Cellular Component (CC) endocytic vesicle 1 Highly Informative Inherited
Cellular Component (CC) centrosome 0.007909 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases1Moderately InformativeInherited
Enzyme Commission (EC)Carboxylic ester hydrolases1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0.005268Moderately InformativeInherited
Enzyme Commission (EC)Phosphoinositide phospholipase C0InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol 3-kinase0Highly InformativeDirect
Enzyme Commission (EC)Phospholipase A(2)0Highly InformativeDirect
Enzyme Commission (EC)Protein kinase C0Highly InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-4,5-bisphosphate 3-kinase0Highly InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-4-phosphate 3-kinase2.368e-16Highly InformativeDirect
Enzyme Commission (EC)Lysophospholipase0.000000000002869Highly InformativeDirect
Enzyme Commission (EC)Phospholipase D0.0002652Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.8456Least InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.1477Moderately InformativeInherited
Phenotypic Abnormality (PA)Neoplasm by histology0.3872InformativeInherited
Phenotypic Abnormality (PA)Sarcoma0.05752Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.02827Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.1512Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.4206Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.9194Least InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.09847Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal myeloid cell morphology0.2057Moderately InformativeInherited
Mammalian Phenotype (MP)neoplasm0.2095Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.5884Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.5963Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.602Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood coagulation0.005803InformativeInherited
Mammalian Phenotype (MP)abnormal ion homeostasis0.1249InformativeInherited
Mammalian Phenotype (MP)abnormal T cell physiology0.8183InformativeInherited
Mammalian Phenotype (MP)increased hamartoma incidence0.001428Highly InformativeInherited
Mammalian Phenotype (MP)abnormal synapse morphology0.002024Highly InformativeInherited
Mammalian Phenotype (MP)increased skin tumor incidence0.00305Highly InformativeInherited
Mammalian Phenotype (MP)abnormal platelet morphology0.01753Highly InformativeInherited
Mammalian Phenotype (MP)abnormal calcium ion homeostasis0.03778Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cytotoxic T cell physiology0.3029Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.0000189Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.00002613Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0.0001397Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.008118Least InformativeInherited
Worm Phenotype (WP)organ system morphology variant0.07823Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.1542Least InformativeInherited
Worm Phenotype (WP)chemical response variant0.0005783Moderately InformativeDirect
Worm Phenotype (WP)cell homeostasis metabolism variant0.005196Moderately InformativeInherited
Worm Phenotype (WP)feeding behavior variant0.05487Moderately InformativeInherited
Worm Phenotype (WP)germ cell morphology variant0.2288Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.7795Moderately InformativeInherited
Worm Phenotype (WP)defecation variant0.00001438InformativeDirect
Worm Phenotype (WP)pharyngeal pumping variant0.0000148InformativeDirect
Worm Phenotype (WP)growth rate variant0.00004286InformativeDirect
Worm Phenotype (WP)locomotor coordination variant0.0001046InformativeDirect
Worm Phenotype (WP)organism pathogen response variant0.0004218InformativeDirect
Worm Phenotype (WP)electrophysiology variant0.0005006InformativeDirect
Worm Phenotype (WP)pattern protein expression variant0.0005438InformativeDirect
Worm Phenotype (WP)muscle system morphology variant0.0008664InformativeDirect
Worm Phenotype (WP)drug resistant0.0009299InformativeDirect
Worm Phenotype (WP)cell stress response variant0.004582InformativeInherited
Worm Phenotype (WP)sexually dimorphic behavior variant0.02196InformativeInherited
Worm Phenotype (WP)localized movement variant0.02679InformativeInherited
Worm Phenotype (WP)protein metabolism variant0.08135InformativeInherited
Worm Phenotype (WP)foraging behavior variant0.08656InformativeInherited
Worm Phenotype (WP)oocyte morphology variant0.7202InformativeInherited
Worm Phenotype (WP)antimicrobial gene expression variant0.00000000006113Highly InformativeDirect
Worm Phenotype (WP)protein subcellular localization variant0.0000000002603Highly InformativeDirect
Worm Phenotype (WP)gonad sheath contractions variant0.000000001307Highly InformativeDirect
Worm Phenotype (WP)drug induced gene expression variant0.000000001371Highly InformativeDirect
Worm Phenotype (WP)response to injury variant0.0000002136Highly InformativeDirect
Worm Phenotype (WP)endomitotic oocytes0.0000002949Highly InformativeDirect
Worm Phenotype (WP)defecation contraction variant0.000000296Highly InformativeDirect
Worm Phenotype (WP)ovulation variant0.0000005566Highly InformativeDirect
Worm Phenotype (WP)osmotic stress response variant0.00002144Highly InformativeDirect
Worm Phenotype (WP)post hermaphrodite contact variant0.0001543Highly InformativeDirect
Worm Phenotype (WP)male mating defective0.0002249Highly InformativeDirect
Worm Phenotype (WP)RNAi response variant0.0002339Highly InformativeDirect
Worm Phenotype (WP)mechanosensation variant0.0903Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)pollen tube cell0.00007155InformativeDirect
Plant structure DEvelopment stage (PDE)pollen development stage0.00003916Moderately InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorus-containing groups0.000000000000001941Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Acyltransferases0.0000001846Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0.003659Moderately InformativeInherited
Enzyme Commission (EC)Carbon-carbon lyases0.9291Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases1Moderately InformativeInherited
Enzyme Commission (EC)Aminoacyltransferases0InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0.00008386InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0.2088InformativeInherited
Enzyme Commission (EC)Carboxylic ester hydrolases1InformativeInherited
Enzyme Commission (EC)HECT-type E3 ubiquitin transferase0Highly InformativeDirect
Enzyme Commission (EC)Protein kinase C0Highly InformativeDirect
Enzyme Commission (EC)Phosphoinositide phospholipase C0Highly InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-4-phosphate 3-kinase2.466e-16Highly InformativeDirect
Enzyme Commission (EC)Lysophospholipase0.00000000000009246Highly InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0.0007137Highly InformativeDirect

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)antineoplastic and immunomodulating agents0.001131Least InformativeInherited
Drugbank ATC_code (DB)nervous system0.3521Least InformativeInherited
Drugbank ATC_code (DB)psychostimulants, agents used for adhd and nootropics0.003723Moderately InformativeInherited
Drugbank ATC_code (DB)hormone antagonists and related agents0.0000000002172InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processDifferentiation0Moderately InformativeDirect
Biological processImmunity0Moderately InformativeDirect
Biological processLipid metabolism0Moderately InformativeDirect
Biological processUbl conjugation pathway0Moderately InformativeDirect
Biological processApoptosis4.822e-16Moderately InformativeDirect
Biological processAutophagy0InformativeDirect
Biological processEndocytosis0InformativeDirect
Biological processInflammatory response0InformativeDirect
Biological processLipid degradation0InformativeDirect
Biological processAngiogenesis0.00000000000002774InformativeDirect
Biological processCell adhesion0.000000001869InformativeDirect
Biological processLipid transport0.000000004613InformativeDirect
Biological processChemotaxis0.00002332InformativeDirect
Biological processPlant defense0.0002361InformativeDirect
Biological processSensory transduction0.0424InformativeInherited
Biological processExocytosis0Highly InformativeDirect
Biological processNeurotransmitter transport0.00000000000000238Highly InformativeDirect
Biological processFertilization0.0000000003861Highly InformativeDirect
Biological processPhagocytosis0.00000005307Highly InformativeDirect
Biological processGrowth regulation0.000003359Highly InformativeDirect
Biological processCilium biogenesis/degradation0.00007111Highly InformativeDirect
Biological processVision0.00007547Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentNucleus0.00000000005632Least InformativeDirect
Cellular componentCytoplasm0.09671Least InformativeInherited
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentEndosome0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0Moderately InformativeDirect
Cellular componentCytoskeleton0.0000000003239Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0.0000000007557Moderately InformativeDirect
Cellular componentGolgi apparatus0.00006149Moderately InformativeDirect
Cellular componentLysosome0.0000000001791InformativeDirect
Cellular componentSynapse0.00000002747InformativeDirect
Coding sequence diversityAlternative splicing0.0000000005094Least InformativeDirect
DiseaseTumor suppressor0.0003889Moderately InformativeDirect
DomainRepeat0Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainCoiled coil0.00000000001301Moderately InformativeDirect
DomainZinc-finger0.0000000002302Moderately InformativeDirect
DomainSH2 domain0.000000000001299InformativeDirect
DomainSH3 domain0.00002614InformativeDirect
DomainSignal-anchor0.00005494InformativeDirect
DomainSH3-binding0.0004066InformativeDirect
Molecular functionMetal-binding0.000000000708Least InformativeDirect
Molecular functionZinc0.00000008455Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionLipid-binding0Moderately InformativeDirect
Molecular functionCalmodulin-binding0.0009909InformativeDirect
Post-translational modificationHydrolase0.000005093Least InformativeDirect
Post-translational modificationTransferase0.1612Least InformativeInherited
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0.0000124Moderately InformativeDirect
Post-translational modificationGTPase activation0InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0InformativeDirect
Post-translational modificationProtein phosphatase0.0000000000003265InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor0.0000000003493InformativeDirect
Post-translational modificationChromatin regulator0.0002429InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)lipid metabolism0.002664Least InformativeInherited
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect
UniPathway (UP)phospholipid metabolism0InformativeDirect
UniPathway (UP)biological regulation0Highly InformativeDirect
UniPathway (UP)phosphatidylinositol phosphate biosynthesis0.00000000005343Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR008973 SSF49562 Protein matches
Abstract

The Ca2+-dependent, lipid-binding domain (CaLB) has been identified in a number of proteins, for example the amino-terminal, 138 amino acid C2 domain of cytosolic phospholipase A2 (cPLA2-C2) which mediates an initial step in the production of lipid mediators of inflammation: the Ca2+-dependent translocation of the enzyme to intracellular membranes with subsequent liberation of arachidonic acid. The domain is composed of eight antiparallel beta-strands with six interconnecting loops that fits the "type II" topology for C2 domains. The structure has been identified as a beta-sandwich in the "Greek key" motif [PubMed9665851].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 25 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a C2 domain (Calcium/lipid-binding domain, CaLB) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 25 hidden Markov models representing the C2 domain (Calcium/lipid-binding domain, CaLB) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]