SUPERFAMILY 1.75 HMM library and genome assignments server


C2 domain (Calcium/lipid-binding domain, CaLB) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   C2 domain-like [ 49561] (5)
Superfamily:   C2 domain (Calcium/lipid-binding domain, CaLB) [ 49562] (2)
Families:   PLC-like (P variant) [ 49563] (11)
  Synaptotagmin-like (S variant) [ 49575] (10)


Superfamily statistics
Genomes (448) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 40,207 34,450 37
Proteins 26,457 22,740 35


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 4.208e-13 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) response to stimulus 4.75e-09 Least Informative Direct
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 7.604e-07 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.0002106 Least Informative Direct
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.001145 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.04421 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.9961 Least Informative Inherited
Biological Process (BP) developmental process 0.568 Least Informative Inherited
Biological Process (BP) lipid biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of localization 0 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) system process 0 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 0 Moderately Informative Direct
Biological Process (BP) regulation of signaling 0 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular localization 0 Moderately Informative Direct
Biological Process (BP) cellular lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 4.314e-12 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 7.929e-10 Moderately Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 1.319e-08 Moderately Informative Direct
Biological Process (BP) immune system process 8.727e-06 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.0001067 Moderately Informative Direct
Biological Process (BP) signal transduction 0.0002093 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.0002414 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.7929 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.03396 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) organ development 0.8007 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.4647 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 0.9971 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.001392 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.07367 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.005384 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.09152 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.02926 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.6903 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.2546 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.2503 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.02013 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) homeostatic process 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.5136 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) vesicle-mediated transport 0 Informative Direct
Biological Process (BP) synaptic transmission 0 Informative Direct
Biological Process (BP) secretion 0 Informative Direct
Biological Process (BP) glycerolipid metabolic process 0 Informative Direct
Biological Process (BP) phospholipid metabolic process 0 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 1.136e-13 Informative Direct
Biological Process (BP) positive regulation of transport 2.499e-12 Informative Direct
Biological Process (BP) cell activation 2.903e-10 Informative Direct
Biological Process (BP) alcohol metabolic process 3.615e-10 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 3.015e-08 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 4.831e-08 Informative Direct
Biological Process (BP) cellular membrane organization 1.033e-07 Informative Direct
Biological Process (BP) regulation of locomotion 2.542e-07 Informative Direct
Biological Process (BP) regulation of system process 3.397e-07 Informative Direct
Biological Process (BP) negative regulation of cell communication 5.981e-07 Informative Direct
Biological Process (BP) response to wounding 8.439e-07 Informative Direct
Biological Process (BP) negative regulation of signaling 1.085e-06 Informative Direct
Biological Process (BP) negative regulation of cell death 1.135e-06 Informative Direct
Biological Process (BP) response to organic nitrogen 6.739e-06 Informative Direct
Biological Process (BP) protein catabolic process 1.052e-05 Informative Direct
Biological Process (BP) regulation of cellular component movement 1.14e-05 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 2.634e-05 Informative Direct
Biological Process (BP) metal ion homeostasis 2.827e-05 Informative Direct
Biological Process (BP) regulation of cell development 2.946e-05 Informative Direct
Biological Process (BP) regulation of anatomical structure size 7.804e-05 Informative Direct
Biological Process (BP) positive regulation of protein metabolic process 0.00023 Informative Direct
Biological Process (BP) locomotion 0.0003006 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0.000434 Informative Direct
Biological Process (BP) regulation of hydrolase activity 0.000692 Informative Direct
Biological Process (BP) positive regulation of immune system process 0.0007629 Informative Direct
Biological Process (BP) regulation of intracellular transport 1 Informative Inherited
Biological Process (BP) regulation of protein localization 1 Informative Inherited
Biological Process (BP) protein localization to organelle 0.8684 Informative Inherited
Biological Process (BP) cellular cation homeostasis 0.1985 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.3567 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.4212 Informative Inherited
Biological Process (BP) negative regulation of molecular function 1 Informative Inherited
Biological Process (BP) negative regulation of cellular metabolic process 1 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 1 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.08622 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.05497 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.2277 Informative Inherited
Biological Process (BP) regulation of response to stress 0.937 Informative Inherited
Biological Process (BP) metal ion transport 0.2847 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.05368 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.08898 Informative Inherited
Biological Process (BP) sensory organ development 0.3178 Informative Inherited
Biological Process (BP) muscle structure development 1 Informative Inherited
Biological Process (BP) muscle tissue development 0.09403 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.06566 Informative Inherited
Biological Process (BP) dephosphorylation 0.9021 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 1 Informative Inherited
Biological Process (BP) organophosphate catabolic process 1 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.651 Informative Inherited
Biological Process (BP) blood circulation 0.1202 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.864 Informative Inherited
Biological Process (BP) regulation of secretion 0.005507 Informative Inherited
Biological Process (BP) regulation of immune effector process 1 Informative Inherited
Biological Process (BP) regulation of immune response 0.6346 Informative Inherited
Biological Process (BP) tissue morphogenesis 1 Informative Inherited
Biological Process (BP) regulation of growth 0.0927 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.5964 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.1078 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.4097 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.0104 Informative Inherited
Biological Process (BP) cellular biogenic amine metabolic process 0.1149 Informative Inherited
Biological Process (BP) cellular modified amino acid metabolic process 0.8164 Informative Inherited
Biological Process (BP) protein phosphorylation 0.001472 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.8508 Informative Inherited
Biological Process (BP) cellular component disassembly 0.06873 Informative Inherited
Biological Process (BP) immune response 0.001839 Informative Inherited
Biological Process (BP) defense response 0.319 Informative Inherited
Biological Process (BP) immune effector process 0.02558 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.6111 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.1137 Informative Inherited
Biological Process (BP) regulation of cell cycle process 1 Informative Inherited
Biological Process (BP) protein modification by small protein conjugation or removal 0.01058 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.652 Informative Inherited
Biological Process (BP) cell projection organization 1 Informative Inherited
Biological Process (BP) cellular component morphogenesis 1 Informative Inherited
Biological Process (BP) generation of neurons 0.4796 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.8243 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.5865 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.6927 Informative Inherited
Biological Process (BP) sexual reproduction 0.378 Informative Inherited
Biological Process (BP) single organism reproductive process 0.8346 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.04762 Informative Inherited
Biological Process (BP) nitrogen compound transport 1 Informative Inherited
Biological Process (BP) regulation of hormone levels 1 Informative Inherited
Biological Process (BP) central nervous system development 0.01793 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.001087 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 1 Informative Inherited
Biological Process (BP) chromosome organization 1 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 0.001485 Informative Inherited
Biological Process (BP) anion transport 1 Informative Inherited
Biological Process (BP) organic acid transport 1 Informative Inherited
Biological Process (BP) lipid transport 0.8873 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.1802 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.7616 Informative Inherited
Biological Process (BP) regulation of ion transport 1 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.6748 Informative Inherited
Biological Process (BP) cellular component movement 0.04895 Informative Inherited
Biological Process (BP) localization of cell 1 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.1667 Informative Inherited
Biological Process (BP) gland development 0.5147 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.0478 Informative Inherited
Biological Process (BP) actin filament-based process 0.001604 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.009555 Informative Inherited
Biological Process (BP) protein transport 0.5289 Informative Inherited
Biological Process (BP) pigment metabolic process 0.6751 Informative Inherited
Biological Process (BP) proteolysis 0.03417 Informative Inherited
Biological Process (BP) response to inorganic substance 0.07755 Informative Inherited
Biological Process (BP) chordate embryonic development 0.638 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) organ morphogenesis 0.3677 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.3274 Informative Inherited
Biological Process (BP) cardiovascular system development 0.008299 Informative Inherited
Biological Process (BP) cell cycle process 1 Informative Inherited
Biological Process (BP) neurotransmitter transport 0 Highly Informative Direct
Biological Process (BP) signal release 0 Highly Informative Direct
Biological Process (BP) regulation of neurotransmitter levels 0 Highly Informative Direct
Biological Process (BP) regulation of cellular component size 0 Highly Informative Direct
Biological Process (BP) exocytosis 0 Highly Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 0 Highly Informative Direct
Biological Process (BP) synaptic vesicle transport 0 Highly Informative Direct
Biological Process (BP) phosphatidylinositol metabolic process 1.348e-14 Highly Informative Direct
Biological Process (BP) protein ubiquitination 4.561e-12 Highly Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 2.554e-11 Highly Informative Direct
Biological Process (BP) modification-dependent protein catabolic process 3.156e-08 Highly Informative Direct
Biological Process (BP) fertilization 3.751e-08 Highly Informative Direct
Biological Process (BP) autophagy 8.173e-08 Highly Informative Direct
Biological Process (BP) regulation of insulin secretion 1.294e-07 Highly Informative Direct
Biological Process (BP) polyol metabolic process 2.658e-07 Highly Informative Direct
Biological Process (BP) glycerophospholipid biosynthetic process 5.146e-07 Highly Informative Direct
Biological Process (BP) plasma membrane organization 1.532e-06 Highly Informative Direct
Biological Process (BP) regulation of ion homeostasis 3.414e-06 Highly Informative Direct
Biological Process (BP) regulation of neurological system process 3.437e-06 Highly Informative Direct
Biological Process (BP) response to calcium ion 8.924e-06 Highly Informative Direct
Biological Process (BP) B cell activation 9.972e-06 Highly Informative Direct
Biological Process (BP) activation of immune response 1.34e-05 Highly Informative Direct
Biological Process (BP) hemostasis 2.082e-05 Highly Informative Direct
Biological Process (BP) cellular calcium ion homeostasis 2.176e-05 Highly Informative Direct
Biological Process (BP) wound healing 2.304e-05 Highly Informative Direct
Biological Process (BP) photoreceptor cell differentiation 4.209e-05 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 6.539e-05 Highly Informative Direct
Biological Process (BP) calcium ion transport 9.265e-05 Highly Informative Direct
Biological Process (BP) negative regulation of cellular component movement 0.000108 Highly Informative Direct
Biological Process (BP) lipid modification 0.0001102 Highly Informative Direct
Biological Process (BP) negative regulation of locomotion 0.0001744 Highly Informative Direct
Biological Process (BP) positive regulation of cell cycle process 0.0001831 Highly Informative Direct
Biological Process (BP) immune response-regulating signaling pathway 0.0001902 Highly Informative Direct
Biological Process (BP) cellular response to peptide hormone stimulus 0.0002978 Highly Informative Direct
Biological Process (BP) actin filament organization 0.0003317 Highly Informative Direct
Biological Process (BP) icosanoid biosynthetic process 0.0004354 Highly Informative Direct
Biological Process (BP) negative regulation of cell development 0.0004537 Highly Informative Direct
Biological Process (BP) response to ethanol 0.0005138 Highly Informative Direct
Biological Process (BP) leukocyte homeostasis 0.0005187 Highly Informative Direct
Biological Process (BP) regulation of protein catabolic process 0.0005198 Highly Informative Direct
Biological Process (BP) regulation of multicellular organism growth 0.0007183 Highly Informative Direct
Biological Process (BP) negative regulation of apoptotic process 0.0008324 Highly Informative Direct
Biological Process (BP) regulation of actin cytoskeleton organization 0.0008764 Highly Informative Direct
Biological Process (BP) muscle fiber development 0.0009015 Highly Informative Direct
Biological Process (BP) response to toxic substance 0.0796 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 1 Highly Informative Inherited
Biological Process (BP) positive regulation of protein transport 1 Highly Informative Inherited
Biological Process (BP) regulation of intracellular protein transport 0.8468 Highly Informative Inherited
Biological Process (BP) negative regulation of phosphorylation 0.03781 Highly Informative Inherited
Biological Process (BP) negative regulation of protein modification process 0.05379 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 0.00571 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.1003 Highly Informative Inherited
Biological Process (BP) organelle localization 1 Highly Informative Inherited
Biological Process (BP) sensory perception 1 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.2829 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 0.03923 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis 0.8619 Highly Informative Inherited
Biological Process (BP) regulation of cell projection organization 0.02686 Highly Informative Inherited
Biological Process (BP) regulation of neuron differentiation 0.4531 Highly Informative Inherited
Biological Process (BP) alcohol catabolic process 0.04582 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.316 Highly Informative Inherited
Biological Process (BP) negative regulation of signal transduction 0.002275 Highly Informative Inherited
Biological Process (BP) regulation of Ras protein signal transduction 0.2659 Highly Informative Inherited
Biological Process (BP) regulation of blood pressure 0.9962 Highly Informative Inherited
Biological Process (BP) regulation of angiogenesis 0.01206 Highly Informative Inherited
Biological Process (BP) regulation of myeloid cell differentiation 0.005304 Highly Informative Inherited
Biological Process (BP) positive regulation of cell differentiation 1 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.01886 Highly Informative Inherited
Biological Process (BP) negative regulation of secretion 1 Highly Informative Inherited
Biological Process (BP) regulation of behavior 0.7341 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 0.004384 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.00522 Highly Informative Inherited
Biological Process (BP) ethanolamine-containing compound metabolic process 0.05527 Highly Informative Inherited
Biological Process (BP) histone modification 1 Highly Informative Inherited
Biological Process (BP) innate immune response 0.002292 Highly Informative Inherited
Biological Process (BP) regulation of purine nucleotide catabolic process 0.04754 Highly Informative Inherited
Biological Process (BP) endosomal transport 0.01455 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane transport 0.002044 Highly Informative Inherited
Biological Process (BP) regulation of multi-organism process 0.2791 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.1441 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.006205 Highly Informative Inherited
Biological Process (BP) regulation of protein complex assembly 0.006534 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.05814 Highly Informative Inherited
Biological Process (BP) hormone transport 0.08624 Highly Informative Inherited
Biological Process (BP) amide transport 0.559 Highly Informative Inherited
Biological Process (BP) protein polymerization 0.1896 Highly Informative Inherited
Biological Process (BP) pattern specification process 1 Highly Informative Inherited
Biological Process (BP) telencephalon development 0.01112 Highly Informative Inherited
Biological Process (BP) monocarboxylic acid transport 0.02542 Highly Informative Inherited
Biological Process (BP) response to alkaloid 0.5685 Highly Informative Inherited
Biological Process (BP) regulation of phospholipase activity 0.3213 Highly Informative Inherited
Biological Process (BP) regulation of sodium ion transport 0.003777 Highly Informative Inherited
Biological Process (BP) positive regulation of cell migration 0.6005 Highly Informative Inherited
Biological Process (BP) regulation of blood coagulation 0.004035 Highly Informative Inherited
Biological Process (BP) response to insulin stimulus 0.01753 Highly Informative Inherited
Biological Process (BP) post-embryonic development 1 Highly Informative Inherited
Biological Process (BP) cell fate commitment 1 Highly Informative Inherited
Biological Process (BP) phenol-containing compound metabolic process 0.04936 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 0.04924 Highly Informative Inherited
Biological Process (BP) positive regulation of secretion 0.1996 Highly Informative Inherited
Biological Process (BP) gastrulation 0.2685 Highly Informative Inherited
Biological Process (BP) cell division 0.1152 Highly Informative Inherited
Molecular Function (MF) binding 1.826e-14 Least Informative Direct
Molecular Function (MF) transferase activity 0.005618 Least Informative Inherited
Molecular Function (MF) hydrolase activity 0.1119 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 0 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 5.348e-11 Moderately Informative Direct
Molecular Function (MF) anion binding 7.762e-08 Moderately Informative Direct
Molecular Function (MF) protein binding 0.0003457 Moderately Informative Direct
Molecular Function (MF) cation binding 0.9054 Moderately Informative Inherited
Molecular Function (MF) heterocyclic compound binding 1 Moderately Informative Inherited
Molecular Function (MF) organic cyclic compound binding 1 Moderately Informative Inherited
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) enzyme activator activity 0 Informative Direct
Molecular Function (MF) GTPase regulator activity 0 Informative Direct
Molecular Function (MF) lipid binding 0 Informative Direct
Molecular Function (MF) phosphoric ester hydrolase activity 4.374e-13 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 1.545e-09 Informative Direct
Molecular Function (MF) ligase activity, forming carbon-nitrogen bonds 7.092e-06 Informative Direct
Molecular Function (MF) receptor binding 0.1891 Informative Inherited
Molecular Function (MF) enzyme binding 0.005941 Informative Inherited
Molecular Function (MF) carboxylic acid binding 1 Informative Inherited
Molecular Function (MF) molecular transducer activity 1 Informative Inherited
Molecular Function (MF) receptor activity 1 Informative Inherited
Molecular Function (MF) nucleic acid binding transcription factor activity 1 Informative Inherited
Molecular Function (MF) DNA binding 1 Informative Inherited
Molecular Function (MF) calcium ion binding 0 Highly Informative Direct
Molecular Function (MF) phospholipase activity 0 Highly Informative Direct
Molecular Function (MF) small conjugating protein ligase activity 5.261e-14 Highly Informative Direct
Molecular Function (MF) GTPase activator activity 1.164e-13 Highly Informative Direct
Molecular Function (MF) phosphoric diester hydrolase activity 8.733e-13 Highly Informative Direct
Molecular Function (MF) channel regulator activity 3.147e-07 Highly Informative Direct
Molecular Function (MF) protein kinase activity 1 Highly Informative Inherited
Molecular Function (MF) transcription factor binding transcription factor activity 0.1938 Highly Informative Inherited
Molecular Function (MF) small GTPase regulator activity 0.04874 Highly Informative Inherited
Molecular Function (MF) phosphoprotein phosphatase activity 1 Highly Informative Inherited
Molecular Function (MF) sequence-specific DNA binding transcription factor activity 1 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 3.264e-12 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) plasma membrane 8.642e-13 Moderately Informative Direct
Cellular Component (CC) vesicle 0 Moderately Informative Direct
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) cytosol 2.724e-05 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 1 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 0.006033 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.2529 Moderately Informative Inherited
Cellular Component (CC) synapse 0 Informative Direct
Cellular Component (CC) neuron part 5.505e-13 Informative Direct
Cellular Component (CC) cell projection part 3.488e-11 Informative Direct
Cellular Component (CC) cell leading edge 2.38e-10 Informative Direct
Cellular Component (CC) intrinsic to plasma membrane 1 Informative Inherited
Cellular Component (CC) secretory granule 0.7311 Informative Inherited
Cellular Component (CC) coated vesicle 0.02083 Informative Inherited
Cellular Component (CC) clathrin-coated vesicle 0 Highly Informative Direct
Cellular Component (CC) vesicle membrane 1.611e-08 Highly Informative Direct
Cellular Component (CC) cytoplasmic vesicle part 9.967e-08 Highly Informative Direct
Cellular Component (CC) synaptic membrane 7.455e-07 Highly Informative Direct
Cellular Component (CC) midbody 5.207e-06 Highly Informative Direct
Cellular Component (CC) cell division site part 0.0002565 Highly Informative Direct
Cellular Component (CC) leading edge membrane 0.0003347 Highly Informative Direct
Cellular Component (CC) symplast 0.0003825 Highly Informative Direct
Cellular Component (CC) internal side of plasma membrane 0.0004828 Highly Informative Direct
Cellular Component (CC) ruffle 0.0007203 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 0.0008801 Highly Informative Direct
Cellular Component (CC) cell body 0.01465 Highly Informative Inherited
Cellular Component (CC) sarcolemma 0.02312 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases1Moderately InformativeInherited
Enzyme Commission (EC)Carboxylic ester hydrolases1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0.005268Moderately InformativeInherited
Enzyme Commission (EC)Phosphoinositide phospholipase C0InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol 3-kinase0Highly InformativeDirect
Enzyme Commission (EC)Phospholipase A(2)0Highly InformativeDirect
Enzyme Commission (EC)Protein kinase C0Highly InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-4,5-bisphosphate 3-kinase0Highly InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-4-phosphate 3-kinase2.368e-16Highly InformativeDirect
Enzyme Commission (EC)Lysophospholipase2.869e-12Highly InformativeDirect
Enzyme Commission (EC)Phospholipase D0.0002652Highly InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.08107Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.1676Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.775Least InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.2828Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lymphocyte morphology0.3011Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune cell physiology0.4269Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell-mediated immunity0.4422Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal adaptive immunity0.4753Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.5021Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal effector T cell morphology0.01347InformativeInherited
Mammalian Phenotype (MP)abnormal blood coagulation0.01634InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic system physiology0.08685InformativeInherited
Mammalian Phenotype (MP)abnormal lymphocyte cell number0.1228InformativeInherited
Mammalian Phenotype (MP)abnormal T cell physiology0.766InformativeInherited
Mammalian Phenotype (MP)abnormal platelet physiology9.964e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal CD8-positive T cell number0.0008094Highly InformativeDirect
Mammalian Phenotype (MP)abnormal synapse morphology0.04538Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cytotoxic T cell physiology0.3412Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant2.11e-05Least InformativeDirect
Worm Phenotype (WP)cell physiology variant3.817e-05Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.01308Least InformativeInherited
Worm Phenotype (WP)growth variant0.6313Least InformativeInherited
Worm Phenotype (WP)organ system development variant0.0004822Moderately InformativeDirect
Worm Phenotype (WP)chemical response variant0.01064Moderately InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.01341Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.01671Moderately InformativeInherited
Worm Phenotype (WP)germ cell morphology variant0.1438Moderately InformativeInherited
Worm Phenotype (WP)locomotion variant0.168Moderately InformativeInherited
Worm Phenotype (WP)protein expression variant6.343e-07InformativeDirect
Worm Phenotype (WP)organism pathogen response variant1.125e-05InformativeDirect
Worm Phenotype (WP)locomotor coordination variant0.0002363InformativeDirect
Worm Phenotype (WP)cell stress response variant0.0002532InformativeDirect
Worm Phenotype (WP)electrophysiology variant0.0003982InformativeDirect
Worm Phenotype (WP)body wall muscle morphology variant0.0006182InformativeDirect
Worm Phenotype (WP)drug resistant0.005929InformativeInherited
Worm Phenotype (WP)copulation variant0.02844InformativeInherited
Worm Phenotype (WP)protein metabolism variant0.1041InformativeInherited
Worm Phenotype (WP)body length variant0.3511InformativeInherited
Worm Phenotype (WP)body width variant0.4921InformativeInherited
Worm Phenotype (WP)male behavior variant1InformativeInherited
Worm Phenotype (WP)protein subcellular localization variant6.054e-11Highly InformativeDirect
Worm Phenotype (WP)drug induced gene expression variant1.099e-09Highly InformativeDirect
Worm Phenotype (WP)gonad sheath contractions variant1.413e-09Highly InformativeDirect
Worm Phenotype (WP)aldicarb resistant6.339e-08Highly InformativeDirect
Worm Phenotype (WP)endomitotic oocytes8.222e-08Highly InformativeDirect
Worm Phenotype (WP)response to injury variant2.093e-07Highly InformativeDirect
Worm Phenotype (WP)osmotic stress response variant3.224e-06Highly InformativeDirect
Worm Phenotype (WP)pharyngeal pumping variant1.751e-05Highly InformativeDirect
Worm Phenotype (WP)protein degradation variant2.01e-05Highly InformativeDirect
Worm Phenotype (WP)growth rate variant2.173e-05Highly InformativeDirect
Worm Phenotype (WP)roller2.202e-05Highly InformativeDirect
Worm Phenotype (WP)ovulation variant3.503e-05Highly InformativeDirect
Worm Phenotype (WP)post hermaphrodite contact variant0.0001156Highly InformativeDirect
Worm Phenotype (WP)male mating defective0.0001307Highly InformativeDirect
Worm Phenotype (WP)defecation contraction variant0.0001598Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0.2484Least InformativeInherited
Yeast Phenotype (YP)ionic stress resistance0.0008134Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)neurophysiology defective0.0004718InformativeDirect
Fly Phenotype (FP)increased cell number0.0005374InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

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FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

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ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)nervous system0Least InformativeDirect
Zebrafish Anatomy (ZA)head0Least InformativeDirect
Zebrafish Anatomy (ZA)cavitated compound organ0Least InformativeDirect
Zebrafish Anatomy (ZA)eye0Moderately InformativeDirect
Zebrafish Anatomy (ZA)trunk0Moderately InformativeDirect
Zebrafish Anatomy (ZA)coelom0InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

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AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)plant cell0.0004993Least InformativeDirect
Plant structure DEvelopment stage (PDE)pollen development stage4.58e-05Moderately InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

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EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0.006083Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases1Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric diester hydrolases0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0.2007InformativeInherited
Enzyme Commission (EC)Carboxylic ester hydrolases1InformativeInherited
Enzyme Commission (EC)Protein kinase C0Highly InformativeDirect
Enzyme Commission (EC)Phosphoinositide phospholipase C0Highly InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-4-phosphate 3-kinase2.399e-16Highly InformativeDirect
Enzyme Commission (EC)Lysophospholipase1.909e-12Highly InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0.0003744Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

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KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processLipid metabolism0Moderately InformativeDirect
Biological processApoptosis1.931e-14Moderately InformativeDirect
Biological processInflammatory response0InformativeDirect
Biological processUbl conjugation pathway0InformativeDirect
Biological processEndocytosis1.221e-12InformativeDirect
Biological processAngiogenesis1.896e-11InformativeDirect
Biological processCell adhesion9.566e-09InformativeDirect
Biological processChemotaxis7.348e-06InformativeDirect
Biological processNeurogenesis0.000414InformativeDirect
Biological processSensory transduction0.03057InformativeInherited
Biological processExocytosis0Highly InformativeDirect
Biological processLipid degradation0Highly InformativeDirect
Biological processNeurotransmitter transport9.192e-16Highly InformativeDirect
Biological processFertilization9.138e-11Highly InformativeDirect
Biological processAutophagy1.185e-06Highly InformativeDirect
Biological processVision4.805e-05Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentNucleus4.525e-07Least InformativeDirect
Cellular componentCytoplasm0.1122Least InformativeInherited
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentEndosome0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0Moderately InformativeDirect
Cellular componentCytoskeleton3.167e-07Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0.0001655Moderately InformativeDirect
Cellular componentSynapse2.665e-09InformativeDirect
Cellular componentLysosome3.166e-07InformativeDirect
Coding sequence diversityAlternative splicing2.386e-06Least InformativeDirect
DiseaseTumor suppressor0.0003515Moderately InformativeDirect
DomainRepeat0Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainCoiled coil7.975e-12Moderately InformativeDirect
DomainSignal-anchor0.000177Moderately InformativeDirect
DomainSH2 domain1.093e-11InformativeDirect
DomainSH3 domain8.761e-05InformativeDirect
DomainSH3-binding0.0004018InformativeDirect
Molecular functionZinc3.81e-10Least InformativeDirect
Molecular functionMetal-binding1.202e-08Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionZinc-finger0Moderately InformativeDirect
Molecular functionLipid-binding6.593e-15InformativeDirect
Post-translational modificationHydrolase1.749e-07Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationGTPase activation0InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0InformativeDirect
Post-translational modificationTransducer0InformativeDirect
Post-translational modificationProtein phosphatase1.995e-11InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor1.958e-09InformativeDirect
Post-translational modificationChromatin regulator9.854e-05InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

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UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)lipid metabolism0.04754Least InformativeInherited
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect
UniPathway (UP)phospholipid metabolism2.048e-12InformativeDirect
UniPathway (UP)phosphatidylinositol phosphate biosynthesis5.575e-13Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR008973 SSF49562 Protein matches
Abstract

The Ca2+-dependent, lipid-binding domain (CaLB) has been identified in a number of proteins, for example the amino-terminal, 138 amino acid C2 domain of cytosolic phospholipase A2 (cPLA2-C2) which mediates an initial step in the production of lipid mediators of inflammation: the Ca2+-dependent translocation of the enzyme to intracellular membranes with subsequent liberation of arachidonic acid. The domain is composed of eight antiparallel beta-strands with six interconnecting loops that fits the "type II" topology for C2 domains. The structure has been identified as a beta-sandwich in the "Greek key" motif [PubMed9665851].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 25 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a C2 domain (Calcium/lipid-binding domain, CaLB) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 25 hidden Markov models representing the C2 domain (Calcium/lipid-binding domain, CaLB) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]