SUPERFAMILY 1.75 HMM library and genome assignments server


C2 domain (Calcium/lipid-binding domain, CaLB) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   C2 domain-like [ 49561] (5)
Superfamily:   C2 domain (Calcium/lipid-binding domain, CaLB) [ 49562] (2)
Families:   PLC-like (P variant) [ 49563] (11)
  Synaptotagmin-like (S variant) [ 49575] (10)


Superfamily statistics
Genomes (454) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 40,772 34,450 37
Proteins 26,860 22,740 35


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.0008683 Least Informative Direct
Biological Process (BP) multicellular organismal process 1.421e-13 Least Informative Direct
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) response to stimulus 5.405e-13 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 4.779e-06 Least Informative Direct
Biological Process (BP) single-organism metabolic process 7.198e-05 Least Informative Direct
Biological Process (BP) protein metabolic process 0.0007856 Least Informative Direct
Biological Process (BP) developmental process 0.4658 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.8335 Least Informative Inherited
Biological Process (BP) cellular localization 0 Moderately Informative Direct
Biological Process (BP) lipid biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of localization 0 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) system process 0 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 5.97e-09 Moderately Informative Direct
Biological Process (BP) immune system process 3.676e-07 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 4.286e-07 Moderately Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 1.643e-06 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 6.7e-05 Moderately Informative Direct
Biological Process (BP) signal transduction 0.000155 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 0.0002057 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.0002162 Moderately Informative Direct
Biological Process (BP) nervous system development 0.01054 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.001899 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) organ development 0.3684 Moderately Informative Inherited
Biological Process (BP) tissue development 0.9786 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) single-organism biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) macromolecule catabolic process 0.008257 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.005517 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.07841 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.001181 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.04293 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.1891 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of programmed cell death 0.8399 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.6546 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.9024 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.7272 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.01385 Moderately Informative Inherited
Biological Process (BP) homeostatic process 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.7438 Moderately Informative Inherited
Biological Process (BP) vesicle-mediated transport 0 Informative Direct
Biological Process (BP) glycerolipid metabolic process 0 Informative Direct
Biological Process (BP) transmission of nerve impulse 0 Informative Direct
Biological Process (BP) secretion by cell 0 Informative Direct
Biological Process (BP) phospholipid metabolic process 0 Informative Direct
Biological Process (BP) cell-cell signaling 0 Informative Direct
Biological Process (BP) positive regulation of transport 1.437e-13 Informative Direct
Biological Process (BP) cell activation 3.646e-11 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 4.957e-11 Informative Direct
Biological Process (BP) regulation of system process 3.597e-10 Informative Direct
Biological Process (BP) organelle localization 4.53e-09 Informative Direct
Biological Process (BP) cation homeostasis 5.623e-09 Informative Direct
Biological Process (BP) alcohol metabolic process 2.654e-08 Informative Direct
Biological Process (BP) negative regulation of cell death 1.032e-07 Informative Direct
Biological Process (BP) cellular chemical homeostasis 4.131e-07 Informative Direct
Biological Process (BP) response to wounding 8.293e-07 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 1.564e-06 Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 6.272e-06 Informative Direct
Biological Process (BP) protein catabolic process 6.751e-06 Informative Direct
Biological Process (BP) response to organonitrogen compound 1.477e-05 Informative Direct
Biological Process (BP) membrane organization 2.688e-05 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 3.937e-05 Informative Direct
Biological Process (BP) regulation of locomotion 4.137e-05 Informative Direct
Biological Process (BP) locomotion 7.483e-05 Informative Direct
Biological Process (BP) positive regulation of protein metabolic process 8.548e-05 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.0001828 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0.0001888 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.000285 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.0003263 Informative Direct
Biological Process (BP) immune response 0.0009813 Informative Direct
Biological Process (BP) protein localization to organelle 0.8019 Informative Inherited
Biological Process (BP) organophosphate catabolic process 1 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.4976 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.1464 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.08502 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.4587 Informative Inherited
Biological Process (BP) metal ion transport 0.1191 Informative Inherited
Biological Process (BP) response to inorganic substance 0.2063 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.001062 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.1763 Informative Inherited
Biological Process (BP) regulation of cell development 0.136 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.7019 Informative Inherited
Biological Process (BP) sensory organ development 0.08002 Informative Inherited
Biological Process (BP) muscle structure development 0.9673 Informative Inherited
Biological Process (BP) muscle tissue development 0.03176 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.07315 Informative Inherited
Biological Process (BP) dephosphorylation 0.9789 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 1 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.0142 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.01281 Informative Inherited
Biological Process (BP) blood circulation 0.07415 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.9804 Informative Inherited
Biological Process (BP) regulation of secretion 0.002523 Informative Inherited
Biological Process (BP) regulation of immune effector process 1 Informative Inherited
Biological Process (BP) regulation of immune response 0.7151 Informative Inherited
Biological Process (BP) organelle assembly 0.3233 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) cellular component morphogenesis 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.004515 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.006656 Informative Inherited
Biological Process (BP) regulation of growth 0.462 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.8515 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.04144 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.00645 Informative Inherited
Biological Process (BP) cellular biogenic amine metabolic process 1 Informative Inherited
Biological Process (BP) cellular modified amino acid metabolic process 0.7424 Informative Inherited
Biological Process (BP) phosphorylation 0.1083 Informative Inherited
Biological Process (BP) defense response 0.4695 Informative Inherited
Biological Process (BP) immune effector process 0.01448 Informative Inherited
Biological Process (BP) secondary metabolic process 1 Informative Inherited
Biological Process (BP) regulation of nucleotide catabolic process 0.5407 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.08098 Informative Inherited
Biological Process (BP) regulation of cell cycle 0.6487 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.9231 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.00653 Informative Inherited
Biological Process (BP) generation of neurons 0.1953 Informative Inherited
Biological Process (BP) cell projection organization 0.988 Informative Inherited
Biological Process (BP) nitrogen compound transport 1 Informative Inherited
Biological Process (BP) regulation of hormone levels 1 Informative Inherited
Biological Process (BP) actin filament-based process 0.03776 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.2223 Informative Inherited
Biological Process (BP) central nervous system development 0.02922 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.009737 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 1 Informative Inherited
Biological Process (BP) chromosome organization 1 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 0.001107 Informative Inherited
Biological Process (BP) protein complex assembly 0.03316 Informative Inherited
Biological Process (BP) anion transport 1 Informative Inherited
Biological Process (BP) organic acid transport 1 Informative Inherited
Biological Process (BP) lipid localization 0.007365 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.7885 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.766 Informative Inherited
Biological Process (BP) regulation of ion transport 1 Informative Inherited
Biological Process (BP) cellular component movement 0.3576 Informative Inherited
Biological Process (BP) localization of cell 1 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.137 Informative Inherited
Biological Process (BP) gland development 0.3734 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 1 Informative Inherited
Biological Process (BP) sexual reproduction 0.889 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) protein transport 0.7876 Informative Inherited
Biological Process (BP) pigment metabolic process 0.6994 Informative Inherited
Biological Process (BP) proteolysis 0.04157 Informative Inherited
Biological Process (BP) organ morphogenesis 0.1038 Informative Inherited
Biological Process (BP) cardiovascular system development 0.01536 Informative Inherited
Biological Process (BP) cell cycle process 1 Informative Inherited
Biological Process (BP) neurotransmitter transport 0 Highly Informative Direct
Biological Process (BP) phosphatidylinositol metabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of neurotransmitter levels 0 Highly Informative Direct
Biological Process (BP) establishment of vesicle localization 0 Highly Informative Direct
Biological Process (BP) exocytosis 0 Highly Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 0 Highly Informative Direct
Biological Process (BP) regulation of cellular response to insulin stimulus 8.092e-13 Highly Informative Direct
Biological Process (BP) protein ubiquitination 9.35e-13 Highly Informative Direct
Biological Process (BP) signal release 2.5e-12 Highly Informative Direct
Biological Process (BP) ubiquitin-dependent protein catabolic process 2.926e-09 Highly Informative Direct
Biological Process (BP) synaptic vesicle localization 7.331e-09 Highly Informative Direct
Biological Process (BP) glycerophospholipid biosynthetic process 4.576e-08 Highly Informative Direct
Biological Process (BP) response to peptide hormone stimulus 4.692e-08 Highly Informative Direct
Biological Process (BP) plasma membrane organization 1.183e-07 Highly Informative Direct
Biological Process (BP) autophagy 1.461e-07 Highly Informative Direct
Biological Process (BP) regulation of ion homeostasis 5.372e-07 Highly Informative Direct
Biological Process (BP) B cell activation 7.113e-07 Highly Informative Direct
Biological Process (BP) photoreceptor cell differentiation 9.08e-07 Highly Informative Direct
Biological Process (BP) response to calcium ion 3.35e-06 Highly Informative Direct
Biological Process (BP) cellular calcium ion homeostasis 3.538e-06 Highly Informative Direct
Biological Process (BP) regulation of wound healing 4.22e-06 Highly Informative Direct
Biological Process (BP) hemostasis 5.421e-06 Highly Informative Direct
Biological Process (BP) calcium ion transport 6.003e-06 Highly Informative Direct
Biological Process (BP) wound healing 2.907e-05 Highly Informative Direct
Biological Process (BP) activation of immune response 3.489e-05 Highly Informative Direct
Biological Process (BP) regulation of hemostasis 3.66e-05 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 4.39e-05 Highly Informative Direct
Biological Process (BP) regulation of protein catabolic process 5.745e-05 Highly Informative Direct
Biological Process (BP) regulation of coagulation 6.625e-05 Highly Informative Direct
Biological Process (BP) response to ethanol 8.501e-05 Highly Informative Direct
Biological Process (BP) fatty acid derivative metabolic process 0.000169 Highly Informative Direct
Biological Process (BP) positive regulation of GTPase activity 0.0001754 Highly Informative Direct
Biological Process (BP) protein phosphorylation 0.000192 Highly Informative Direct
Biological Process (BP) muscle fiber development 0.0003848 Highly Informative Direct
Biological Process (BP) negative regulation of neuron death 0.0004613 Highly Informative Direct
Biological Process (BP) immune response-regulating signaling pathway 0.0006699 Highly Informative Direct
Biological Process (BP) positive regulation of organelle organization 0.0007369 Highly Informative Direct
Biological Process (BP) positive regulation of cell cycle process 0.0007781 Highly Informative Direct
Biological Process (BP) eye morphogenesis 0.0008638 Highly Informative Direct
Biological Process (BP) negative regulation of cellular component movement 0.0009015 Highly Informative Direct
Biological Process (BP) regulation of phospholipase activity 0.2543 Highly Informative Inherited
Biological Process (BP) response to toxic substance 0.2163 Highly Informative Inherited
Biological Process (BP) regulation of organ morphogenesis 0.3596 Highly Informative Inherited
Biological Process (BP) alcohol catabolic process 0.02529 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 0.007882 Highly Informative Inherited
Biological Process (BP) sensory perception 1 Highly Informative Inherited
Biological Process (BP) regulation of hormone secretion 0.1205 Highly Informative Inherited
Biological Process (BP) regulation of peptide transport 0.2129 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0.1209 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.2834 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 0.00832 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.5191 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.02447 Highly Informative Inherited
Biological Process (BP) lipid modification 0.001831 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.1804 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.1735 Highly Informative Inherited
Biological Process (BP) regulation of cell size 1 Highly Informative Inherited
Biological Process (BP) regulation of blood pressure 0.9627 Highly Informative Inherited
Biological Process (BP) regulation of angiogenesis 0.005922 Highly Informative Inherited
Biological Process (BP) regulation of myeloid cell differentiation 0.004288 Highly Informative Inherited
Biological Process (BP) positive regulation of cell differentiation 1 Highly Informative Inherited
Biological Process (BP) polyol metabolic process 0.00655 Highly Informative Inherited
Biological Process (BP) regulation of neuron apoptotic process 0.001587 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.02564 Highly Informative Inherited
Biological Process (BP) negative regulation of secretion 1 Highly Informative Inherited
Biological Process (BP) regulation of behavior 0.8529 Highly Informative Inherited
Biological Process (BP) developmental maturation 0.004836 Highly Informative Inherited
Biological Process (BP) cell projection assembly 0.1213 Highly Informative Inherited
Biological Process (BP) cellular component assembly involved in morphogenesis 0.3008 Highly Informative Inherited
Biological Process (BP) cell part morphogenesis 0.4045 Highly Informative Inherited
Biological Process (BP) negative regulation of growth 0.4927 Highly Informative Inherited
Biological Process (BP) regulation of multicellular organism growth 0.1463 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.002856 Highly Informative Inherited
Biological Process (BP) ethanolamine-containing compound metabolic process 0.02034 Highly Informative Inherited
Biological Process (BP) histone modification 1 Highly Informative Inherited
Biological Process (BP) protein dephosphorylation 0.3228 Highly Informative Inherited
Biological Process (BP) innate immune response 0.003844 Highly Informative Inherited
Biological Process (BP) cell proliferation 0.7214 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane transport 0.002835 Highly Informative Inherited
Biological Process (BP) regulation of transporter activity 0.002771 Highly Informative Inherited
Biological Process (BP) regulation of multi-organism process 0.5918 Highly Informative Inherited
Biological Process (BP) regulation of response to biotic stimulus 0.7983 Highly Informative Inherited
Biological Process (BP) neuron projection development 1 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.004505 Highly Informative Inherited
Biological Process (BP) regulation of actin cytoskeleton organization 0.01038 Highly Informative Inherited
Biological Process (BP) regulation of protein complex assembly 0.006686 Highly Informative Inherited
Biological Process (BP) amide transport 0.09161 Highly Informative Inherited
Biological Process (BP) hormone transport 0.002877 Highly Informative Inherited
Biological Process (BP) actin filament organization 0.0292 Highly Informative Inherited
Biological Process (BP) protein polymerization 0.285 Highly Informative Inherited
Biological Process (BP) telencephalon development 0.00833 Highly Informative Inherited
Biological Process (BP) monocarboxylic acid transport 0.03587 Highly Informative Inherited
Biological Process (BP) response to alkaloid 0.4538 Highly Informative Inherited
Biological Process (BP) regulation of sodium ion transport 0.001014 Highly Informative Inherited
Biological Process (BP) positive regulation of cell migration 0.4266 Highly Informative Inherited
Biological Process (BP) cellular response to peptide 0.004206 Highly Informative Inherited
Biological Process (BP) post-embryonic development 1 Highly Informative Inherited
Biological Process (BP) cell fate commitment 1 Highly Informative Inherited
Biological Process (BP) fertilization 0.001484 Highly Informative Inherited
Biological Process (BP) phenol-containing compound metabolic process 0.03969 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 0.0283 Highly Informative Inherited
Biological Process (BP) regulation of synaptic transmission 0.11 Highly Informative Inherited
Biological Process (BP) positive regulation of secretion 0.1719 Highly Informative Inherited
Biological Process (BP) leukocyte homeostasis 0.001649 Highly Informative Inherited
Biological Process (BP) cell division 0.03877 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) hydrolase activity 0.06309 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 0 Moderately Informative Direct
Molecular Function (MF) anion binding 1.422e-08 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 1.792e-08 Moderately Informative Direct
Molecular Function (MF) cation binding 0.8036 Moderately Informative Inherited
Molecular Function (MF) lyase activity 1 Moderately Informative Inherited
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) GTPase regulator activity 0 Informative Direct
Molecular Function (MF) lipid binding 0 Informative Direct
Molecular Function (MF) enzyme activator activity 3.809e-15 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 2.01e-09 Informative Direct
Molecular Function (MF) ligase activity, forming carbon-nitrogen bonds 1.205e-05 Informative Direct
Molecular Function (MF) enzyme binding 0.0009943 Informative Direct
Molecular Function (MF) phosphatase activity 1 Informative Inherited
Molecular Function (MF) receptor binding 0.1352 Informative Inherited
Molecular Function (MF) carboxylic acid binding 0.8203 Informative Inherited
Molecular Function (MF) carbon-carbon lyase activity 0.07631 Informative Inherited
Molecular Function (MF) molecular transducer activity 1 Informative Inherited
Molecular Function (MF) receptor activity 1 Informative Inherited
Molecular Function (MF) nucleic acid binding transcription factor activity 1 Informative Inherited
Molecular Function (MF) calcium ion binding 0 Highly Informative Direct
Molecular Function (MF) small conjugating protein ligase activity 0 Highly Informative Direct
Molecular Function (MF) phospholipase activity 0 Highly Informative Direct
Molecular Function (MF) phosphoric diester hydrolase activity 4.349e-13 Highly Informative Direct
Molecular Function (MF) GTPase activator activity 2.231e-11 Highly Informative Direct
Molecular Function (MF) Ras GTPase binding 2.922e-11 Highly Informative Direct
Molecular Function (MF) channel regulator activity 7.099e-08 Highly Informative Direct
Molecular Function (MF) amino acid binding 1.194e-07 Highly Informative Direct
Molecular Function (MF) protein kinase activity 1 Highly Informative Inherited
Molecular Function (MF) transcription factor binding transcription factor activity 0.1273 Highly Informative Inherited
Molecular Function (MF) small GTPase regulator activity 0.3617 Highly Informative Inherited
Molecular Function (MF) phosphoprotein phosphatase activity 1 Highly Informative Inherited
Molecular Function (MF) carboxy-lyase activity 0.0049 Highly Informative Inherited
Molecular Function (MF) sequence-specific DNA binding transcription factor activity 1 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.1966 Least Informative Inherited
Cellular Component (CC) vesicle 0 Moderately Informative Direct
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) cytosol 2.716e-05 Moderately Informative Direct
Cellular Component (CC) extracellular region part 1 Moderately Informative Inherited
Cellular Component (CC) plasma membrane part 0.6284 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.4282 Moderately Informative Inherited
Cellular Component (CC) synapse part 0 Informative Direct
Cellular Component (CC) cell leading edge 2.571e-10 Informative Direct
Cellular Component (CC) secretory granule 0.7446 Informative Inherited
Cellular Component (CC) coated vesicle 0.1165 Informative Inherited
Cellular Component (CC) clathrin-coated vesicle 0 Highly Informative Direct
Cellular Component (CC) synaptic membrane 1.968e-08 Highly Informative Direct
Cellular Component (CC) midbody 1.218e-05 Highly Informative Direct
Cellular Component (CC) symplast 8.804e-05 Highly Informative Direct
Cellular Component (CC) leading edge membrane 0.0001445 Highly Informative Direct
Cellular Component (CC) cell division site part 0.0003556 Highly Informative Direct
Cellular Component (CC) cilium 0.0007176 Highly Informative Direct
Cellular Component (CC) ruffle 0.0009445 Highly Informative Direct
Cellular Component (CC) cell body 0.02852 Highly Informative Inherited
Cellular Component (CC) cytoplasmic vesicle membrane 0.8541 Highly Informative Inherited
Cellular Component (CC) sarcolemma 0.01423 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases1Moderately InformativeInherited
Enzyme Commission (EC)Carboxylic ester hydrolases1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0.005268Moderately InformativeInherited
Enzyme Commission (EC)Phosphoinositide phospholipase C0InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol 3-kinase0Highly InformativeDirect
Enzyme Commission (EC)Phospholipase A(2)0Highly InformativeDirect
Enzyme Commission (EC)Protein kinase C0Highly InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-4,5-bisphosphate 3-kinase0Highly InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-4-phosphate 3-kinase2.368e-16Highly InformativeDirect
Enzyme Commission (EC)Lysophospholipase2.869e-12Highly InformativeDirect
Enzyme Commission (EC)Phospholipase D0.0002652Highly InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.09967Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.2199Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.8174Least InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic system physiology0.09825Moderately InformativeInherited
Mammalian Phenotype (MP)tumorigenesis0.188Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell-mediated immunity0.2734Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal adaptive immunity0.305Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune cell physiology0.3753Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.4701Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood coagulation0.01781InformativeInherited
Mammalian Phenotype (MP)abnormal ion homeostasis0.05847InformativeInherited
Mammalian Phenotype (MP)abnormal T cell physiology0.8859InformativeInherited
Mammalian Phenotype (MP)increased hamartoma incidence0.000882Highly InformativeDirect
Mammalian Phenotype (MP)increased skin tumor incidence0.0009072Highly InformativeDirect
Mammalian Phenotype (MP)abnormal calcium ion homeostasis0.03875Highly InformativeInherited
Mammalian Phenotype (MP)abnormal bone marrow cell morphology/development0.1458Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cytotoxic T cell physiology0.3461Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant2.11e-05Least InformativeDirect
Worm Phenotype (WP)cell physiology variant3.817e-05Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.01308Least InformativeInherited
Worm Phenotype (WP)growth variant0.6313Least InformativeInherited
Worm Phenotype (WP)organ system development variant0.0004822Moderately InformativeDirect
Worm Phenotype (WP)chemical response variant0.01064Moderately InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.01341Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.01671Moderately InformativeInherited
Worm Phenotype (WP)germ cell morphology variant0.1438Moderately InformativeInherited
Worm Phenotype (WP)locomotion variant0.168Moderately InformativeInherited
Worm Phenotype (WP)protein expression variant6.343e-07InformativeDirect
Worm Phenotype (WP)organism pathogen response variant1.125e-05InformativeDirect
Worm Phenotype (WP)locomotor coordination variant0.0002363InformativeDirect
Worm Phenotype (WP)cell stress response variant0.0002532InformativeDirect
Worm Phenotype (WP)electrophysiology variant0.0003982InformativeDirect
Worm Phenotype (WP)body wall muscle morphology variant0.0006182InformativeDirect
Worm Phenotype (WP)drug resistant0.005929InformativeInherited
Worm Phenotype (WP)copulation variant0.02844InformativeInherited
Worm Phenotype (WP)protein metabolism variant0.1041InformativeInherited
Worm Phenotype (WP)body length variant0.3511InformativeInherited
Worm Phenotype (WP)body width variant0.4921InformativeInherited
Worm Phenotype (WP)male behavior variant1InformativeInherited
Worm Phenotype (WP)protein subcellular localization variant6.054e-11Highly InformativeDirect
Worm Phenotype (WP)drug induced gene expression variant1.099e-09Highly InformativeDirect
Worm Phenotype (WP)gonad sheath contractions variant1.413e-09Highly InformativeDirect
Worm Phenotype (WP)aldicarb resistant6.339e-08Highly InformativeDirect
Worm Phenotype (WP)endomitotic oocytes8.222e-08Highly InformativeDirect
Worm Phenotype (WP)response to injury variant2.093e-07Highly InformativeDirect
Worm Phenotype (WP)osmotic stress response variant3.224e-06Highly InformativeDirect
Worm Phenotype (WP)pharyngeal pumping variant1.751e-05Highly InformativeDirect
Worm Phenotype (WP)protein degradation variant2.01e-05Highly InformativeDirect
Worm Phenotype (WP)growth rate variant2.173e-05Highly InformativeDirect
Worm Phenotype (WP)roller2.202e-05Highly InformativeDirect
Worm Phenotype (WP)ovulation variant3.503e-05Highly InformativeDirect
Worm Phenotype (WP)post hermaphrodite contact variant0.0001156Highly InformativeDirect
Worm Phenotype (WP)male mating defective0.0001307Highly InformativeDirect
Worm Phenotype (WP)defecation contraction variant0.0001598Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0.1559Least InformativeInherited
Yeast Phenotype (YP)ionic stress resistance0.0008548Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)neurophysiology defective0.0002956InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)pollen tube cell7.056e-05InformativeDirect
Plant structure DEvelopment stage (PDE)pollen development stage3.891e-05Moderately InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0.007988Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases1Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric diester hydrolases0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0.0009768InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0.1945InformativeInherited
Enzyme Commission (EC)Carboxylic ester hydrolases1InformativeInherited
Enzyme Commission (EC)Phosphatidylinositol-4-phosphate 3-kinase0Highly InformativeDirect
Enzyme Commission (EC)Protein kinase C0Highly InformativeDirect
Enzyme Commission (EC)Phosphoinositide phospholipase C0Highly InformativeDirect
Enzyme Commission (EC)Lysophospholipase1.004e-12Highly InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0.0003609Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processApoptosis0Moderately InformativeDirect
Biological processLipid metabolism0Moderately InformativeDirect
Biological processCell cycle0.0006578Moderately InformativeDirect
Biological processInflammatory response0InformativeDirect
Biological processUbl conjugation pathway0InformativeDirect
Biological processAngiogenesis1.023e-14InformativeDirect
Biological processEndocytosis1.848e-12InformativeDirect
Biological processCell adhesion5.285e-10InformativeDirect
Biological processChemotaxis9.648e-06InformativeDirect
Biological processNeurogenesis0.0005382InformativeDirect
Biological processSensory transduction0.03115InformativeInherited
Biological processExocytosis0Highly InformativeDirect
Biological processLipid degradation0Highly InformativeDirect
Biological processNeurotransmitter transport1.166e-15Highly InformativeDirect
Biological processFertilization2.017e-10Highly InformativeDirect
Biological processAutophagy1.788e-06Highly InformativeDirect
Biological processCilium biogenesis/degradation1.207e-05Highly InformativeDirect
Biological processVision5.13e-05Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentNucleus7.919e-07Least InformativeDirect
Cellular componentCytoplasm0.05711Least InformativeInherited
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentEndosome0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0Moderately InformativeDirect
Cellular componentCytoskeleton3.402e-08Moderately InformativeDirect
Cellular componentGolgi apparatus0.0001964Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0.0002297Moderately InformativeDirect
Cellular componentSynapse3.494e-10InformativeDirect
Cellular componentLysosome4.297e-07InformativeDirect
Coding sequence diversityAlternative splicing3.073e-06Least InformativeDirect
DiseaseTumor suppressor0.0003488Moderately InformativeDirect
DomainRepeat0Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainCoiled coil1.592e-13Moderately InformativeDirect
DomainZinc-finger6.619e-12Moderately InformativeDirect
DomainSH2 domain4.48e-12InformativeDirect
DomainSH3 domain4.997e-05InformativeDirect
DomainSignal-anchor0.0002129InformativeDirect
DomainSH3-binding0.0003178InformativeDirect
Molecular functionZinc8.04e-10Least InformativeDirect
Molecular functionMetal-binding5.628e-08Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionLipid-binding0InformativeDirect
Post-translational modificationHydrolase2.403e-07Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationGTPase activation0InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0InformativeDirect
Post-translational modificationTransducer0InformativeDirect
Post-translational modificationProtein phosphatase2.185e-11InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor2.261e-09InformativeDirect
Post-translational modificationChromatin regulator0.0001128InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation3.122e-05Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR008973 SSF49562 Protein matches
Abstract

The Ca2+-dependent, lipid-binding domain (CaLB) has been identified in a number of proteins, for example the amino-terminal, 138 amino acid C2 domain of cytosolic phospholipase A2 (cPLA2-C2) which mediates an initial step in the production of lipid mediators of inflammation: the Ca2+-dependent translocation of the enzyme to intracellular membranes with subsequent liberation of arachidonic acid. The domain is composed of eight antiparallel beta-strands with six interconnecting loops that fits the "type II" topology for C2 domains. The structure has been identified as a beta-sandwich in the "Greek key" motif [PubMed9665851].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 25 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a C2 domain (Calcium/lipid-binding domain, CaLB) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 25 hidden Markov models representing the C2 domain (Calcium/lipid-binding domain, CaLB) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]