SUPERFAMILY 1.75 HMM library and genome assignments server


C2 domain (Calcium/lipid-binding domain, CaLB) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   C2 domain-like [ 49561] (5)
Superfamily:   C2 domain (Calcium/lipid-binding domain, CaLB) [ 49562] (2)
Families:   PLC-like (P variant) [ 49563] (11)
  Synaptotagmin-like (S variant) [ 49575] (10)


Superfamily statistics
Genomes (505) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 46,882 45,964 37
Proteins 31,093 30,598 35


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 0.0001527 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) response to stimulus 1.649e-12 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 6.002e-09 Least Informative Direct
Biological Process (BP) single-organism metabolic process 8.148e-05 Least Informative Direct
Biological Process (BP) developmental process 0.1723 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.003373 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.8731 Least Informative Inherited
Biological Process (BP) cellular localization 0 Moderately Informative Direct
Biological Process (BP) regulation of localization 0 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) system process 0 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 1.426e-08 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 2.592e-07 Moderately Informative Direct
Biological Process (BP) immune system process 1.94e-06 Moderately Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 2.234e-06 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 2.673e-05 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.000338 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.0009472 Moderately Informative Direct
Biological Process (BP) signal transduction 0.0009763 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 0.01682 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.004203 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.7013 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) single-organism biosynthetic process 0.9905 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.01987 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.1776 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.001566 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.0667 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.1557 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.8599 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.6907 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.7054 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.01738 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.007976 Moderately Informative Inherited
Biological Process (BP) tissue development 0.8342 Moderately Informative Inherited
Biological Process (BP) organ development 0.2243 Moderately Informative Inherited
Biological Process (BP) vesicle-mediated transport 0 Informative Direct
Biological Process (BP) synaptic transmission 0 Informative Direct
Biological Process (BP) glycerolipid metabolic process 0 Informative Direct
Biological Process (BP) secretion by cell 0 Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 0 Informative Direct
Biological Process (BP) phospholipid metabolic process 0 Informative Direct
Biological Process (BP) positive regulation of transport 7.043e-14 Informative Direct
Biological Process (BP) regulation of system process 2.252e-13 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 2.944e-13 Informative Direct
Biological Process (BP) negative regulation of transport 1.142e-08 Informative Direct
Biological Process (BP) cation homeostasis 2.055e-08 Informative Direct
Biological Process (BP) alcohol metabolic process 5.767e-08 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 1.279e-07 Informative Direct
Biological Process (BP) response to wounding 2.009e-07 Informative Direct
Biological Process (BP) organelle localization 2.67e-07 Informative Direct
Biological Process (BP) protein catabolic process 8.463e-07 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 1.073e-06 Informative Direct
Biological Process (BP) locomotion 1.262e-06 Informative Direct
Biological Process (BP) negative regulation of cell death 2.375e-06 Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 3.685e-06 Informative Direct
Biological Process (BP) leukocyte activation 3.689e-06 Informative Direct
Biological Process (BP) response to organonitrogen compound 1.346e-05 Informative Direct
Biological Process (BP) positive regulation of protein metabolic process 3.829e-05 Informative Direct
Biological Process (BP) cellular chemical homeostasis 4.978e-05 Informative Direct
Biological Process (BP) cellular macromolecular complex assembly 5.803e-05 Informative Direct
Biological Process (BP) cellular membrane organization 6.573e-05 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 7.177e-05 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 8.024e-05 Informative Direct
Biological Process (BP) regulation of secretion 0.0001482 Informative Direct
Biological Process (BP) regulation of locomotion 0.0001942 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.000429 Informative Direct
Biological Process (BP) intracellular signal transduction 0.0005926 Informative Direct
Biological Process (BP) central nervous system development 0.0007049 Informative Direct
Biological Process (BP) immune response 0.0007575 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0.0007681 Informative Direct
Biological Process (BP) response to nutrient levels 0.0009988 Informative Direct
Biological Process (BP) protein localization to organelle 0.4726 Informative Inherited
Biological Process (BP) organophosphate catabolic process 1 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.5124 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.1819 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.08796 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.6858 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.008606 Informative Inherited
Biological Process (BP) metal ion transport 0.1361 Informative Inherited
Biological Process (BP) response to inorganic substance 0.1598 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.009621 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.1916 Informative Inherited
Biological Process (BP) regulation of cell development 0.1464 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.868 Informative Inherited
Biological Process (BP) sensory organ development 0.158 Informative Inherited
Biological Process (BP) muscle structure development 0.322 Informative Inherited
Biological Process (BP) muscle tissue development 0.02288 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.1609 Informative Inherited
Biological Process (BP) dephosphorylation 0.9117 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 1 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.03802 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.6011 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.0109 Informative Inherited
Biological Process (BP) blood circulation 0.1024 Informative Inherited
Biological Process (BP) positive regulation of developmental process 1 Informative Inherited
Biological Process (BP) regulation of immune effector process 1 Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.04308 Informative Inherited
Biological Process (BP) regulation of immune response 0.9372 Informative Inherited
Biological Process (BP) regulation of cell activation 0.03305 Informative Inherited
Biological Process (BP) organelle assembly 0.7129 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) cellular component morphogenesis 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.01031 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.01138 Informative Inherited
Biological Process (BP) regulation of growth 0.6625 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.8107 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.05957 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.01031 Informative Inherited
Biological Process (BP) cellular biogenic amine metabolic process 1 Informative Inherited
Biological Process (BP) phosphorylation 0.2235 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.8817 Informative Inherited
Biological Process (BP) defense response 0.597 Informative Inherited
Biological Process (BP) immune effector process 0.01157 Informative Inherited
Biological Process (BP) secondary metabolic process 1 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.06843 Informative Inherited
Biological Process (BP) regulation of cell cycle process 1 Informative Inherited
Biological Process (BP) protein modification by small protein conjugation or removal 0.008588 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.9193 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.006948 Informative Inherited
Biological Process (BP) generation of neurons 0.322 Informative Inherited
Biological Process (BP) cell projection organization 1 Informative Inherited
Biological Process (BP) actin filament-based process 0.06332 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.1687 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 1 Informative Inherited
Biological Process (BP) chromosome organization 1 Informative Inherited
Biological Process (BP) anion transport 1 Informative Inherited
Biological Process (BP) organic acid transport 1 Informative Inherited
Biological Process (BP) lipid localization 0.02628 Informative Inherited
Biological Process (BP) nitrogen compound transport 1 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.8157 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.7678 Informative Inherited
Biological Process (BP) regulation of ion transport 1 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.001307 Informative Inherited
Biological Process (BP) cellular component movement 0.5078 Informative Inherited
Biological Process (BP) localization of cell 1 Informative Inherited
Biological Process (BP) regulation of hormone levels 1 Informative Inherited
Biological Process (BP) gland development 0.5167 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 1 Informative Inherited
Biological Process (BP) sexual reproduction 0.9307 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) protein transport 0.9785 Informative Inherited
Biological Process (BP) pigment metabolic process 0.6925 Informative Inherited
Biological Process (BP) proteolysis 0.01688 Informative Inherited
Biological Process (BP) cardiovascular system development 0.01865 Informative Inherited
Biological Process (BP) organ morphogenesis 0.05239 Informative Inherited
Biological Process (BP) cell cycle process 1 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.5923 Informative Inherited
Biological Process (BP) neurotransmitter transport 0 Highly Informative Direct
Biological Process (BP) regulation of neurotransmitter levels 0 Highly Informative Direct
Biological Process (BP) establishment of synaptic vesicle localization 0 Highly Informative Direct
Biological Process (BP) exocytosis 0 Highly Informative Direct
Biological Process (BP) regulation of exocytosis 0 Highly Informative Direct
Biological Process (BP) phosphatidylinositol metabolic process 3.755e-15 Highly Informative Direct
Biological Process (BP) signal release 9.78e-13 Highly Informative Direct
Biological Process (BP) protein ubiquitination 1.033e-12 Highly Informative Direct
Biological Process (BP) regulation of cellular response to insulin stimulus 1.368e-11 Highly Informative Direct
Biological Process (BP) ubiquitin-dependent protein catabolic process 6.93e-10 Highly Informative Direct
Biological Process (BP) glycerophospholipid biosynthetic process 1.844e-08 Highly Informative Direct
Biological Process (BP) response to peptide hormone stimulus 3.098e-08 Highly Informative Direct
Biological Process (BP) positive regulation of catabolic process 1.178e-07 Highly Informative Direct
Biological Process (BP) regulation of wound healing 3.753e-07 Highly Informative Direct
Biological Process (BP) autophagy 6.099e-07 Highly Informative Direct
Biological Process (BP) cellular calcium ion homeostasis 9.141e-07 Highly Informative Direct
Biological Process (BP) response to calcium ion 1.162e-06 Highly Informative Direct
Biological Process (BP) B cell activation 5.555e-06 Highly Informative Direct
Biological Process (BP) calcium ion transport 1.081e-05 Highly Informative Direct
Biological Process (BP) regulation of protein catabolic process 1.334e-05 Highly Informative Direct
Biological Process (BP) regulation of protein complex assembly 1.822e-05 Highly Informative Direct
Biological Process (BP) regulation of hemostasis 3.442e-05 Highly Informative Direct
Biological Process (BP) vesicle organization 4.028e-05 Highly Informative Direct
Biological Process (BP) hormone transport 4.721e-05 Highly Informative Direct
Biological Process (BP) regulation of protein kinase B signaling cascade 5.283e-05 Highly Informative Direct
Biological Process (BP) muscle fiber development 5.457e-05 Highly Informative Direct
Biological Process (BP) regulation of coagulation 6.225e-05 Highly Informative Direct
Biological Process (BP) wound healing 6.381e-05 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 6.957e-05 Highly Informative Direct
Biological Process (BP) icosanoid metabolic process 0.0001029 Highly Informative Direct
Biological Process (BP) regulation of transmembrane transport 0.0001263 Highly Informative Direct
Biological Process (BP) immune response-regulating cell surface receptor signaling pathway 0.0001528 Highly Informative Direct
Biological Process (BP) immune response-activating signal transduction 0.0003191 Highly Informative Direct
Biological Process (BP) fatty acid derivative biosynthetic process 0.0005729 Highly Informative Direct
Biological Process (BP) regulation of G-protein coupled receptor protein signaling pathway 0.0005795 Highly Informative Direct
Biological Process (BP) protein phosphorylation 0.0006509 Highly Informative Direct
Biological Process (BP) organelle fusion 0.0006864 Highly Informative Direct
Biological Process (BP) negative regulation of neuron death 0.000745 Highly Informative Direct
Biological Process (BP) coagulation 0.0009996 Highly Informative Direct
Biological Process (BP) negative regulation of apoptotic process 0.004661 Highly Informative Inherited
Biological Process (BP) regulation of phospholipase activity 0.2426 Highly Informative Inherited
Biological Process (BP) response to toxic substance 0.2463 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 0.01712 Highly Informative Inherited
Biological Process (BP) regulation of organ morphogenesis 0.3315 Highly Informative Inherited
Biological Process (BP) establishment of protein localization to organelle 0.4018 Highly Informative Inherited
Biological Process (BP) cellular component disassembly 0.1612 Highly Informative Inherited
Biological Process (BP) alcohol catabolic process 0.03121 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 0.01094 Highly Informative Inherited
Biological Process (BP) regulation of ion homeostasis 0.002736 Highly Informative Inherited
Biological Process (BP) sensory perception 1 Highly Informative Inherited
Biological Process (BP) regulation of hormone secretion 0.01847 Highly Informative Inherited
Biological Process (BP) regulation of peptide transport 0.1 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0.2082 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.2789 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 0.01311 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.9773 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.01636 Highly Informative Inherited
Biological Process (BP) lipid modification 0.002611 Highly Informative Inherited
Biological Process (BP) multi-organism cellular process 0.273 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.1134 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.4028 Highly Informative Inherited
Biological Process (BP) regulation of cell size 1 Highly Informative Inherited
Biological Process (BP) regulation of blood pressure 1 Highly Informative Inherited
Biological Process (BP) regulation of angiogenesis 0.003781 Highly Informative Inherited
Biological Process (BP) regulation of myeloid cell differentiation 0.00302 Highly Informative Inherited
Biological Process (BP) response to alcohol 0.3876 Highly Informative Inherited
Biological Process (BP) interaction with host 0.07851 Highly Informative Inherited
Biological Process (BP) polyol metabolic process 0.005957 Highly Informative Inherited
Biological Process (BP) regulation of neuron apoptotic process 0.002003 Highly Informative Inherited
Biological Process (BP) negative regulation of leukocyte activation 0.07903 Highly Informative Inherited
Biological Process (BP) negative regulation of secretion 1 Highly Informative Inherited
Biological Process (BP) negative regulation of immune effector process 0.03403 Highly Informative Inherited
Biological Process (BP) regulation of behavior 0.8561 Highly Informative Inherited
Biological Process (BP) cilium organization 0.003263 Highly Informative Inherited
Biological Process (BP) cell projection assembly 0.05648 Highly Informative Inherited
Biological Process (BP) cellular component assembly involved in morphogenesis 0.3421 Highly Informative Inherited
Biological Process (BP) cell part morphogenesis 0.4353 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 0.005384 Highly Informative Inherited
Biological Process (BP) regulation of multicellular organism growth 0.2081 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.00176 Highly Informative Inherited
Biological Process (BP) ethanolamine-containing compound metabolic process 0.01904 Highly Informative Inherited
Biological Process (BP) histone modification 1 Highly Informative Inherited
Biological Process (BP) protein dephosphorylation 0.3605 Highly Informative Inherited
Biological Process (BP) post-embryonic development 1 Highly Informative Inherited
Biological Process (BP) innate immune response 0.008759 Highly Informative Inherited
Biological Process (BP) leukocyte proliferation 0.00536 Highly Informative Inherited
Biological Process (BP) regulation of cell division 0.2636 Highly Informative Inherited
Biological Process (BP) positive regulation of cell cycle process 0.002944 Highly Informative Inherited
Biological Process (BP) regulation of transporter activity 0.01006 Highly Informative Inherited
Biological Process (BP) regulation of multi-organism process 0.5047 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.005203 Highly Informative Inherited
Biological Process (BP) neuron projection development 1 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.0107 Highly Informative Inherited
Biological Process (BP) regulation of actin cytoskeleton organization 0.003342 Highly Informative Inherited
Biological Process (BP) actin filament organization 0.1849 Highly Informative Inherited
Biological Process (BP) protein polymerization 0.5934 Highly Informative Inherited
Biological Process (BP) monocarboxylic acid transport 0.03924 Highly Informative Inherited
Biological Process (BP) amide transport 0.009189 Highly Informative Inherited
Biological Process (BP) response to alkaloid 0.4906 Highly Informative Inherited
Biological Process (BP) positive regulation of cell migration 0.4297 Highly Informative Inherited
Biological Process (BP) cellular response to peptide 0.003241 Highly Informative Inherited
Biological Process (BP) respiratory system development 0.2979 Highly Informative Inherited
Biological Process (BP) cell fate commitment 1 Highly Informative Inherited
Biological Process (BP) fertilization 0.002286 Highly Informative Inherited
Biological Process (BP) phenol-containing compound metabolic process 0.04758 Highly Informative Inherited
Biological Process (BP) mesenchyme development 0.3688 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 0.02306 Highly Informative Inherited
Biological Process (BP) regulation of synaptic transmission 0.02453 Highly Informative Inherited
Biological Process (BP) leukocyte homeostasis 0.001421 Highly Informative Inherited
Biological Process (BP) cell division 0.03439 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) transferase activity 0.01058 Least Informative Inherited
Molecular Function (MF) hydrolase activity 0.03968 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 0 Moderately Informative Direct
Molecular Function (MF) anion binding 3.122e-10 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 2.709e-08 Moderately Informative Direct
Molecular Function (MF) cation binding 0.6695 Moderately Informative Inherited
Molecular Function (MF) lyase activity 1 Moderately Informative Inherited
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) GTPase regulator activity 0 Informative Direct
Molecular Function (MF) lipid binding 0 Informative Direct
Molecular Function (MF) enzyme activator activity 1.562e-15 Informative Direct
Molecular Function (MF) phosphoric ester hydrolase activity 2.838e-13 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 5.463e-10 Informative Direct
Molecular Function (MF) ligase activity 9.15e-06 Informative Direct
Molecular Function (MF) enzyme binding 0.0001641 Informative Direct
Molecular Function (MF) carboxylic acid binding 0.7092 Informative Inherited
Molecular Function (MF) receptor binding 0.2503 Informative Inherited
Molecular Function (MF) amide binding 0.8072 Informative Inherited
Molecular Function (MF) carbon-carbon lyase activity 0.09952 Informative Inherited
Molecular Function (MF) molecular transducer activity 1 Informative Inherited
Molecular Function (MF) receptor activity 1 Informative Inherited
Molecular Function (MF) nucleic acid binding transcription factor activity 1 Informative Inherited
Molecular Function (MF) calcium ion binding 0 Highly Informative Direct
Molecular Function (MF) lipase activity 0 Highly Informative Direct
Molecular Function (MF) Ras GTPase binding 7.52e-15 Highly Informative Direct
Molecular Function (MF) small conjugating protein ligase activity 1.044e-14 Highly Informative Direct
Molecular Function (MF) phosphoric diester hydrolase activity 2.751e-14 Highly Informative Direct
Molecular Function (MF) GTPase activator activity 7.157e-12 Highly Informative Direct
Molecular Function (MF) amino acid binding 4.845e-09 Highly Informative Direct
Molecular Function (MF) channel regulator activity 6.04e-09 Highly Informative Direct
Molecular Function (MF) alcohol binding 5.104e-06 Highly Informative Direct
Molecular Function (MF) hormone binding 0.0299 Highly Informative Inherited
Molecular Function (MF) protein kinase activity 1 Highly Informative Inherited
Molecular Function (MF) transcription factor binding transcription factor activity 0.05407 Highly Informative Inherited
Molecular Function (MF) protein domain specific binding 0.02859 Highly Informative Inherited
Molecular Function (MF) peptide binding 0.2195 Highly Informative Inherited
Molecular Function (MF) small GTPase regulator activity 0.3449 Highly Informative Inherited
Molecular Function (MF) phosphoprotein phosphatase activity 1 Highly Informative Inherited
Molecular Function (MF) carboxy-lyase activity 0.006404 Highly Informative Inherited
Molecular Function (MF) sequence-specific DNA binding transcription factor activity 1 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.9309 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) plasma membrane 5.277e-12 Moderately Informative Direct
Cellular Component (CC) vesicle 0 Moderately Informative Direct
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) cytosol 5.381e-05 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.8973 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 1 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.1383 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.06867 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.08464 Moderately Informative Inherited
Cellular Component (CC) synapse part 0 Informative Direct
Cellular Component (CC) cell leading edge 1.304e-09 Informative Direct
Cellular Component (CC) cell junction 5.504e-06 Informative Direct
Cellular Component (CC) extracellular membrane-bounded organelle 0.0009222 Informative Direct
Cellular Component (CC) neuron projection 1 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) secretory granule 0.4115 Informative Inherited
Cellular Component (CC) coated vesicle 0.04378 Informative Inherited
Cellular Component (CC) clathrin-coated vesicle 0 Highly Informative Direct
Cellular Component (CC) extrinsic to plasma membrane 8.27e-06 Highly Informative Direct
Cellular Component (CC) midbody 3.09e-05 Highly Informative Direct
Cellular Component (CC) intrinsic to organelle membrane 4.534e-05 Highly Informative Direct
Cellular Component (CC) symplast 0.0001243 Highly Informative Direct
Cellular Component (CC) cilium part 0.0004889 Highly Informative Direct
Cellular Component (CC) cell division site part 0.0007956 Highly Informative Direct
Cellular Component (CC) cell body 0.03239 Highly Informative Inherited
Cellular Component (CC) centrosome 0.006657 Highly Informative Inherited
Cellular Component (CC) cytoplasmic vesicle membrane 0.7639 Highly Informative Inherited
Cellular Component (CC) sarcolemma 0.0195 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases1Moderately InformativeInherited
Enzyme Commission (EC)Carboxylic ester hydrolases1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0.005268Moderately InformativeInherited
Enzyme Commission (EC)Phosphoinositide phospholipase C0InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol 3-kinase0Highly InformativeDirect
Enzyme Commission (EC)Phospholipase A(2)0Highly InformativeDirect
Enzyme Commission (EC)Protein kinase C0Highly InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-4,5-bisphosphate 3-kinase0Highly InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-4-phosphate 3-kinase2.368e-16Highly InformativeDirect
Enzyme Commission (EC)Lysophospholipase2.869e-12Highly InformativeDirect
Enzyme Commission (EC)Phospholipase D0.0002652Highly InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.1168Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.3144Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.9002Least InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell physiology0.03857Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell-mediated immunity0.1674Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal adaptive immunity0.1926Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune cell physiology0.2493Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood coagulation0.04355InformativeInherited
Mammalian Phenotype (MP)abnormal ion homeostasis0.06074InformativeInherited
Mammalian Phenotype (MP)abnormal bone marrow cell morphology/development0.08384InformativeInherited
Mammalian Phenotype (MP)abnormal T cell physiology0.8382InformativeInherited
Mammalian Phenotype (MP)abnormal megakaryocyte morphology0.002745Highly InformativeInherited
Mammalian Phenotype (MP)abnormal calcium ion homeostasis0.04172Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cytotoxic T cell physiology0.3475Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant2.11e-05Least InformativeDirect
Worm Phenotype (WP)cell physiology variant3.817e-05Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.01308Least InformativeInherited
Worm Phenotype (WP)growth variant0.6313Least InformativeInherited
Worm Phenotype (WP)organ system development variant0.0004822Moderately InformativeDirect
Worm Phenotype (WP)chemical response variant0.01064Moderately InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.01341Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.01671Moderately InformativeInherited
Worm Phenotype (WP)germ cell morphology variant0.1438Moderately InformativeInherited
Worm Phenotype (WP)locomotion variant0.168Moderately InformativeInherited
Worm Phenotype (WP)protein expression variant6.343e-07InformativeDirect
Worm Phenotype (WP)organism pathogen response variant1.125e-05InformativeDirect
Worm Phenotype (WP)locomotor coordination variant0.0002363InformativeDirect
Worm Phenotype (WP)cell stress response variant0.0002532InformativeDirect
Worm Phenotype (WP)electrophysiology variant0.0003982InformativeDirect
Worm Phenotype (WP)body wall muscle morphology variant0.0006182InformativeDirect
Worm Phenotype (WP)drug resistant0.005929InformativeInherited
Worm Phenotype (WP)copulation variant0.02844InformativeInherited
Worm Phenotype (WP)protein metabolism variant0.1041InformativeInherited
Worm Phenotype (WP)body length variant0.3511InformativeInherited
Worm Phenotype (WP)body width variant0.4921InformativeInherited
Worm Phenotype (WP)male behavior variant1InformativeInherited
Worm Phenotype (WP)protein subcellular localization variant6.054e-11Highly InformativeDirect
Worm Phenotype (WP)drug induced gene expression variant1.099e-09Highly InformativeDirect
Worm Phenotype (WP)gonad sheath contractions variant1.413e-09Highly InformativeDirect
Worm Phenotype (WP)aldicarb resistant6.339e-08Highly InformativeDirect
Worm Phenotype (WP)endomitotic oocytes8.222e-08Highly InformativeDirect
Worm Phenotype (WP)response to injury variant2.093e-07Highly InformativeDirect
Worm Phenotype (WP)osmotic stress response variant3.224e-06Highly InformativeDirect
Worm Phenotype (WP)pharyngeal pumping variant1.751e-05Highly InformativeDirect
Worm Phenotype (WP)protein degradation variant2.01e-05Highly InformativeDirect
Worm Phenotype (WP)growth rate variant2.173e-05Highly InformativeDirect
Worm Phenotype (WP)roller2.202e-05Highly InformativeDirect
Worm Phenotype (WP)ovulation variant3.503e-05Highly InformativeDirect
Worm Phenotype (WP)post hermaphrodite contact variant0.0001156Highly InformativeDirect
Worm Phenotype (WP)male mating defective0.0001307Highly InformativeDirect
Worm Phenotype (WP)defecation contraction variant0.0001598Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0.1584Least InformativeInherited
Yeast Phenotype (YP)ionic stress resistance0.000858Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)neurophysiology defective0.0007843InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0.605Least InformativeInherited
Zebrafish Anatomy (ZA)immune system0.3391Moderately InformativeInherited
Zebrafish Anatomy (ZA)granulocyte0.0006323InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)pollen tube cell7.056e-05InformativeDirect
Plant structure DEvelopment stage (PDE)pollen development stage3.891e-05Moderately InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0.008434Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases1Moderately InformativeInherited
Enzyme Commission (EC)Carbon-carbon lyases1Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric diester hydrolases0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0.0009499InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0.1922InformativeInherited
Enzyme Commission (EC)Carboxy-lyases0.6845InformativeInherited
Enzyme Commission (EC)Carboxylic ester hydrolases1InformativeInherited
Enzyme Commission (EC)Phosphatidylinositol-4-phosphate 3-kinase0Highly InformativeDirect
Enzyme Commission (EC)Protein kinase C0Highly InformativeDirect
Enzyme Commission (EC)Phosphoinositide phospholipase C0Highly InformativeDirect
Enzyme Commission (EC)Lysophospholipase9.14e-13Highly InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0.0003524Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processApoptosis0Moderately InformativeDirect
Biological processLipid metabolism0Moderately InformativeDirect
Biological processCell cycle0.0005755Moderately InformativeDirect
Biological processEndocytosis0InformativeDirect
Biological processInflammatory response0InformativeDirect
Biological processUbl conjugation pathway0InformativeDirect
Biological processAngiogenesis1.047e-14InformativeDirect
Biological processCell adhesion6.218e-10InformativeDirect
Biological processLipid transport1.253e-09InformativeDirect
Biological processChemotaxis1.176e-05InformativeDirect
Biological processNeurogenesis0.0006266InformativeDirect
Biological processSensory transduction0.03329InformativeInherited
Biological processAutophagy0Highly InformativeDirect
Biological processExocytosis0Highly InformativeDirect
Biological processLipid degradation0Highly InformativeDirect
Biological processNeurotransmitter transport9.345e-16Highly InformativeDirect
Biological processFertilization2.406e-10Highly InformativeDirect
Biological processCilium biogenesis/degradation1.516e-05Highly InformativeDirect
Biological processVision5.5e-05Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentNucleus1.283e-06Least InformativeDirect
Cellular componentCytoplasm0.08334Least InformativeInherited
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentEndosome0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0Moderately InformativeDirect
Cellular componentEndoplasmic reticulum4.307e-10Moderately InformativeDirect
Cellular componentCytoskeleton3.695e-08Moderately InformativeDirect
Cellular componentGolgi apparatus0.0002227Moderately InformativeDirect
Cellular componentSynapse6.914e-10InformativeDirect
Cellular componentLysosome4.395e-07InformativeDirect
Coding sequence diversityAlternative splicing9.63e-09Least InformativeDirect
DiseaseTumor suppressor0.0008903Moderately InformativeDirect
DomainRepeat0Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainCoiled coil2.174e-12Moderately InformativeDirect
DomainZinc-finger6.879e-11Moderately InformativeDirect
DomainSH2 domain7.608e-12InformativeDirect
DomainSH3 domain7.045e-05InformativeDirect
DomainSignal-anchor0.0002497InformativeDirect
DomainSH3-binding0.0003847InformativeDirect
Molecular functionZinc1.658e-09Least InformativeDirect
Molecular functionMetal-binding2.091e-09Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionLipid-binding0InformativeDirect
Post-translational modificationHydrolase3.839e-07Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationGTPase activation0InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0InformativeDirect
Post-translational modificationTransducer0InformativeDirect
Post-translational modificationProtein phosphatase1.845e-11InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor2.246e-09InformativeDirect
Post-translational modificationChromatin regulator0.0001337InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation3.084e-05Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)lipid metabolism0.01104Least InformativeInherited
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect
UniPathway (UP)phospholipid metabolism3.565e-15InformativeDirect
UniPathway (UP)biological regulation0Highly InformativeDirect
UniPathway (UP)phosphatidylinositol phosphate biosynthesis7.582e-12Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR008973 SSF49562 Protein matches
Abstract

The Ca2+-dependent, lipid-binding domain (CaLB) has been identified in a number of proteins, for example the amino-terminal, 138 amino acid C2 domain of cytosolic phospholipase A2 (cPLA2-C2) which mediates an initial step in the production of lipid mediators of inflammation: the Ca2+-dependent translocation of the enzyme to intracellular membranes with subsequent liberation of arachidonic acid. The domain is composed of eight antiparallel beta-strands with six interconnecting loops that fits the "type II" topology for C2 domains. The structure has been identified as a beta-sandwich in the "Greek key" motif [PubMed9665851].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 25 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a C2 domain (Calcium/lipid-binding domain, CaLB) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 25 hidden Markov models representing the C2 domain (Calcium/lipid-binding domain, CaLB) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]