SUPERFAMILY 1.75 HMM library and genome assignments server

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C2 domain (Calcium/lipid-binding domain, CaLB) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   C2 domain-like [ 49561] (5)
Superfamily:   C2 domain (Calcium/lipid-binding domain, CaLB) [ 49562] (2)
Families:   PLC-like (P variant) [ 49563] (11)
  Synaptotagmin-like (S variant) [ 49575] (10)


Superfamily statistics
Genomes (511) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 47,362 45,964 37
Proteins 31,435 30,598 35


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biological regulation0.0062390Least InformativeInherited
Biological Process (BP)regulation of cell communication0.0000017310Moderately InformativeDirect
Biological Process (BP)regulation of signaling0.000078850Moderately InformativeDirect
Biological Process (BP)regulation of response to stimulus0.00051350.00000000001572Moderately InformativeDirect
Biological Process (BP)positive regulation of cellular process0.039210.09746Moderately InformativeInherited
Biological Process (BP)regulation of molecular function0.0000074330.1332Moderately InformativeInherited
Biological Process (BP)positive regulation of catalytic activity0.0000000029090.1893InformativeInherited
Biological Process (BP)regulation of hydrolase activity0.0000000018210.3066InformativeInherited
Biological Process (BP)positive regulation of signal transduction0.0087810.189InformativeInherited
Biological Process (BP)regulation of GTPase activity0.00000000000002320.000002755Highly InformativeDirect
Biological Process (BP)positive regulation of hydrolase activity0.00000000002220.007951Highly InformativeInherited
Molecular Function (MF)binding0.097360.00000000000005796Least InformativeInherited
Molecular Function (MF)molecular function regulator0.00000011130.0000000000002979Moderately InformativeDirect
Molecular Function (MF)anion binding0.000017650Moderately InformativeDirect
Molecular Function (MF)enzyme activator activity0.000000000022140.000000000001574InformativeDirect
Molecular Function (MF)phospholipid binding0.00000000022380InformativeDirect
Molecular Function (MF)GTPase regulator activity0.0000000000000093130Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0.0000000001377 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.5344 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 0.9521 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.7447 Least Informative Inherited
Biological Process (BP) regulation of cell communication 0 Moderately Informative Direct
Biological Process (BP) regulation of signaling 0 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0.00000000001572 Moderately Informative Direct
Biological Process (BP) regulation of localization 0 Moderately Informative Direct
Biological Process (BP) single organism signaling 0 Moderately Informative Direct
Biological Process (BP) cellular localization 0 Moderately Informative Direct
Biological Process (BP) single-organism transport 0 Moderately Informative Direct
Biological Process (BP) lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0 Moderately Informative Direct
Biological Process (BP) cell communication 0 Moderately Informative Direct
Biological Process (BP) organophosphate biosynthetic process 0.0000000000001154 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.00000000006073 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.000000009101 Moderately Informative Direct
Biological Process (BP) immune system process 0.00003438 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.00009591 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.0005945 Moderately Informative Direct
Biological Process (BP) reproduction 0.0007401 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.001292 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.8492 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.2201 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.1332 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.002753 Moderately Informative Inherited
Biological Process (BP) protein complex biogenesis 0.003393 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) nitrogen compound transport 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.309 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 0.6172 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.001363 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.008913 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.68 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.09746 Moderately Informative Inherited
Biological Process (BP) system development 0.2063 Moderately Informative Inherited
Biological Process (BP) cell-cell signaling 0 Informative Direct
Biological Process (BP) phospholipid metabolic process 0 Informative Direct
Biological Process (BP) organelle localization 0 Informative Direct
Biological Process (BP) secretion by cell 0 Informative Direct
Biological Process (BP) vesicle-mediated transport 0 Informative Direct
Biological Process (BP) glycerolipid metabolic process 0 Informative Direct
Biological Process (BP) single-organism intracellular transport 0 Informative Direct
Biological Process (BP) cellular protein complex assembly 0.0000000001055 Informative Direct
Biological Process (BP) cell activation 0.0000000002067 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.0000000009782 Informative Direct
Biological Process (BP) regulation of catabolic process 0.000000009235 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.00000006564 Informative Direct
Biological Process (BP) alcohol metabolic process 0.0000009046 Informative Direct
Biological Process (BP) regulation of protein modification process 0.000005138 Informative Direct
Biological Process (BP) membrane organization 0.000005963 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.000006045 Informative Direct
Biological Process (BP) immune effector process 0.000007748 Informative Direct
Biological Process (BP) locomotion 0.00001243 Informative Direct
Biological Process (BP) positive regulation of transport 0.00001291 Informative Direct
Biological Process (BP) regulation of growth 0.00001441 Informative Direct
Biological Process (BP) negative regulation of transport 0.00003216 Informative Direct
Biological Process (BP) regulation of locomotion 0.00003625 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.0000738 Informative Direct
Biological Process (BP) response to nitrogen compound 0.0001594 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0.0001975 Informative Direct
Biological Process (BP) negative regulation of signaling 0.0001985 Informative Direct
Biological Process (BP) negative regulation of cell death 0.000659 Informative Direct
Biological Process (BP) regulation of secretion 0.0006594 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.0007773 Informative Direct
Biological Process (BP) behavior 0.0009999 Informative Direct
Biological Process (BP) positive regulation of signal transduction 0.189 Informative Inherited
Biological Process (BP) organelle assembly 0.9202 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.05699 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.09366 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.08978 Informative Inherited
Biological Process (BP) regulation of proteolysis 0.4698 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 0.3066 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.004715 Informative Inherited
Biological Process (BP) transmembrane transport 1 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 0.01616 Informative Inherited
Biological Process (BP) cell wall organization or biogenesis 0.2927 Informative Inherited
Biological Process (BP) cellular response to inorganic substance 0.08407 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.001107 Informative Inherited
Biological Process (BP) regulation of cell differentiation 0.08194 Informative Inherited
Biological Process (BP) ion homeostasis 0.8189 Informative Inherited
Biological Process (BP) metal ion transport 0.07549 Informative Inherited
Biological Process (BP) response to metal ion 0.1992 Informative Inherited
Biological Process (BP) regulation of establishment of protein localization 0.4772 Informative Inherited
Biological Process (BP) regulation of peptide transport 1 Informative Inherited
Biological Process (BP) regulation of transcription, DNA-templated 1 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.6777 Informative Inherited
Biological Process (BP) single organism reproductive process 0.8056 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.001285 Informative Inherited
Biological Process (BP) dephosphorylation 0.2482 Informative Inherited
Biological Process (BP) ammonium ion metabolic process 0.03965 Informative Inherited
Biological Process (BP) regulation of phosphorylation 0.5067 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.1893 Informative Inherited
Biological Process (BP) proteolysis 0.5187 Informative Inherited
Biological Process (BP) intracellular protein transport 1 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.9543 Informative Inherited
Biological Process (BP) sensory organ development 0.1606 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.5598 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.1599 Informative Inherited
Biological Process (BP) cellular response to hormone stimulus 0.003755 Informative Inherited
Biological Process (BP) regulation of cell proliferation 1 Informative Inherited
Biological Process (BP) multi-organism reproductive process 0.003406 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.1792 Informative Inherited
Biological Process (BP) pigment metabolic process 0.3288 Informative Inherited
Biological Process (BP) immune response 0.07431 Informative Inherited
Biological Process (BP) secondary metabolic process 0.785 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.4685 Informative Inherited
Biological Process (BP) generation of neurons 0.01253 Informative Inherited
Biological Process (BP) cell development 0.8771 Informative Inherited
Biological Process (BP) actin filament-based process 0.04401 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.001404 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.8178 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.9072 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.06305 Informative Inherited
Biological Process (BP) regulation of hormone levels 1 Informative Inherited
Biological Process (BP) supramolecular fiber organization 0.3122 Informative Inherited
Biological Process (BP) lipid localization 0.1818 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.8979 Informative Inherited
Biological Process (BP) chromosome organization 1 Informative Inherited
Biological Process (BP) phosphorylation 1 Informative Inherited
Biological Process (BP) central nervous system development 0.6475 Informative Inherited
Biological Process (BP) movement of cell or subcellular component 1 Informative Inherited
Biological Process (BP) regulation of system process 0.96 Informative Inherited
Biological Process (BP) post-embryonic development 0.2753 Informative Inherited
Biological Process (BP) response to extracellular stimulus 0.1291 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.8445 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 0.3948 Informative Inherited
Biological Process (BP) microtubule-based process 0.885 Informative Inherited
Biological Process (BP) protein localization to organelle 0.4675 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 0.01185 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.004854 Informative Inherited
Biological Process (BP) positive regulation of immune response 0.08979 Informative Inherited
Biological Process (BP) regulation of cellular localization 0.4424 Informative Inherited
Biological Process (BP) tissue development 1 Informative Inherited
Biological Process (BP) embryo development 1 Informative Inherited
Biological Process (BP) circulatory system development 0.4727 Informative Inherited
Biological Process (BP) cell cycle process 0.3919 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.9058 Informative Inherited
Biological Process (BP) regulation of GTPase activity 0.000002755 Highly Informative Direct
Biological Process (BP) regulation of neurotransmitter levels 0 Highly Informative Direct
Biological Process (BP) trans-synaptic signaling 0 Highly Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 0 Highly Informative Direct
Biological Process (BP) signal release 0 Highly Informative Direct
Biological Process (BP) vesicle localization 0 Highly Informative Direct
Biological Process (BP) endomembrane system organization 0.000000000009436 Highly Informative Direct
Biological Process (BP) fertilization 0.00000000001515 Highly Informative Direct
Biological Process (BP) phosphatidylinositol metabolic process 0.00000000003512 Highly Informative Direct
Biological Process (BP) polyol metabolic process 0.00000000004722 Highly Informative Direct
Biological Process (BP) response to peptide hormone 0.000000001903 Highly Informative Direct
Biological Process (BP) autophagy 0.000000002666 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 0.0000001498 Highly Informative Direct
Biological Process (BP) lipid modification 0.0000002063 Highly Informative Direct
Biological Process (BP) regulation of actin polymerization or depolymerization 0.000001683 Highly Informative Direct
Biological Process (BP) negative regulation of homeostatic process 0.000008681 Highly Informative Direct
Biological Process (BP) regulation of sequence-specific DNA binding transcription factor activity 0.000009088 Highly Informative Direct
Biological Process (BP) positive regulation of growth 0.00001181 Highly Informative Direct
Biological Process (BP) positive regulation of secretion by cell 0.00002866 Highly Informative Direct
Biological Process (BP) phosphatidylcholine metabolic process 0.00004156 Highly Informative Direct
Biological Process (BP) coagulation 0.00004164 Highly Informative Direct
Biological Process (BP) cellular response to calcium ion 0.00004569 Highly Informative Direct
Biological Process (BP) post-embryonic animal morphogenesis 0.00004718 Highly Informative Direct
Biological Process (BP) regulation of proteolysis involved in cellular protein catabolic process 0.00006574 Highly Informative Direct
Biological Process (BP) divalent metal ion transport 0.00007458 Highly Informative Direct
Biological Process (BP) regeneration 0.00007994 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.0001791 Highly Informative Direct
Biological Process (BP) response to nutrient levels 0.0001912 Highly Informative Direct
Biological Process (BP) cell maturation 0.0006633 Highly Informative Direct
Biological Process (BP) response to carbohydrate 0.0007315 Highly Informative Direct
Biological Process (BP) negative regulation of catabolic process 0.0008323 Highly Informative Direct
Biological Process (BP) cellular calcium ion homeostasis 0.0009725 Highly Informative Direct
Biological Process (BP) positive regulation of cellular component biogenesis 0.005895 Highly Informative Inherited
Biological Process (BP) cell projection assembly 0.3663 Highly Informative Inherited
Biological Process (BP) positive regulation of cell development 0.001776 Highly Informative Inherited
Biological Process (BP) positive regulation of nervous system development 0.007579 Highly Informative Inherited
Biological Process (BP) regulation of cell growth 0.04607 Highly Informative Inherited
Biological Process (BP) inorganic cation transmembrane transport 0.002238 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 0.2193 Highly Informative Inherited
Biological Process (BP) regulation of wound healing 0.9503 Highly Informative Inherited
Biological Process (BP) organelle fusion 0.01519 Highly Informative Inherited
Biological Process (BP) single-organism membrane fusion 0.4815 Highly Informative Inherited
Biological Process (BP) extracellular matrix organization 0.04027 Highly Informative Inherited
Biological Process (BP) cellular response to organonitrogen compound 0.003427 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 0.1365 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.6773 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.4476 Highly Informative Inherited
Biological Process (BP) myeloid cell differentiation 0.007189 Highly Informative Inherited
Biological Process (BP) regulation of ion homeostasis 0.002922 Highly Informative Inherited
Biological Process (BP) inner ear development 0.00382 Highly Informative Inherited
Biological Process (BP) negative regulation of nervous system development 0.4958 Highly Informative Inherited
Biological Process (BP) negative regulation of cell development 0.4979 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 0.1507 Highly Informative Inherited
Biological Process (BP) spermatogenesis 0.08324 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 0.06735 Highly Informative Inherited
Biological Process (BP) positive regulation of lymphocyte activation 0.2874 Highly Informative Inherited
Biological Process (BP) positive regulation of cell adhesion 0.4977 Highly Informative Inherited
Biological Process (BP) regulation of cell size 0.9958 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 0.8734 Highly Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.007951 Highly Informative Inherited
Biological Process (BP) regulation of neuron apoptotic process 0.008815 Highly Informative Inherited
Biological Process (BP) proteolysis involved in cellular protein catabolic process 0.002231 Highly Informative Inherited
Biological Process (BP) neuron development 0.004968 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 1 Highly Informative Inherited
Biological Process (BP) lymphocyte activation 0.7043 Highly Informative Inherited
Biological Process (BP) negative regulation of growth 0.4513 Highly Informative Inherited
Biological Process (BP) immune response-activating signal transduction 0.004942 Highly Informative Inherited
Biological Process (BP) glycerophospholipid biosynthetic process 0.0511 Highly Informative Inherited
Biological Process (BP) tube morphogenesis 0.7282 Highly Informative Inherited
Biological Process (BP) phenol-containing compound metabolic process 0.07431 Highly Informative Inherited
Biological Process (BP) innate immune response 0.5952 Highly Informative Inherited
Biological Process (BP) positive regulation of response to external stimulus 0.9543 Highly Informative Inherited
Biological Process (BP) plasma membrane bounded cell projection organization 0.7611 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.09813 Highly Informative Inherited
Biological Process (BP) regulation of protein polymerization 0.001989 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.001228 Highly Informative Inherited
Biological Process (BP) germ cell development 0.03359 Highly Informative Inherited
Biological Process (BP) cellular component disassembly 0.008101 Highly Informative Inherited
Biological Process (BP) pattern specification process 1 Highly Informative Inherited
Biological Process (BP) protein secretion 1 Highly Informative Inherited
Biological Process (BP) actin filament organization 0.009088 Highly Informative Inherited
Biological Process (BP) protein polymerization 0.6426 Highly Informative Inherited
Biological Process (BP) maintenance of location 0.3108 Highly Informative Inherited
Biological Process (BP) histone modification 0.7981 Highly Informative Inherited
Biological Process (BP) protein modification by small protein conjugation 0.00134 Highly Informative Inherited
Biological Process (BP) brain development 0.082 Highly Informative Inherited
Biological Process (BP) cellular response to extracellular stimulus 0.8282 Highly Informative Inherited
Biological Process (BP) muscle structure development 1 Highly Informative Inherited
Biological Process (BP) microtubule cytoskeleton organization 1 Highly Informative Inherited
Biological Process (BP) modification-dependent macromolecule catabolic process 0.001559 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.7104 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte migration 0.6686 Highly Informative Inherited
Biological Process (BP) negative regulation of locomotion 0.07853 Highly Informative Inherited
Biological Process (BP) negative regulation of cellular component movement 0.08173 Highly Informative Inherited
Biological Process (BP) epithelial cell differentiation 0.2271 Highly Informative Inherited
Biological Process (BP) phagocytosis 0.9323 Highly Informative Inherited
Biological Process (BP) lysosome organization 0.001534 Highly Informative Inherited
Biological Process (BP) vesicle organization 0.00427 Highly Informative Inherited
Biological Process (BP) wound healing 0.06885 Highly Informative Inherited
Biological Process (BP) sensory organ morphogenesis 0.06456 Highly Informative Inherited
Biological Process (BP) gastrulation 0.0917 Highly Informative Inherited
Biological Process (BP) cell division 0.06379 Highly Informative Inherited
Molecular Function (MF) binding 0.00000000000005796 Least Informative Direct
Molecular Function (MF) hydrolase activity 0.000000000002728 Least Informative Direct
Molecular Function (MF) transferase activity 0.05341 Least Informative Inherited
Molecular Function (MF) molecular function regulator 0.0000000000002979 Moderately Informative Direct
Molecular Function (MF) anion binding 0 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 0 Moderately Informative Direct
Molecular Function (MF) metal ion binding 0.000000000003472 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.0000000005968 Moderately Informative Direct
Molecular Function (MF) small molecule binding 1 Moderately Informative Inherited
Molecular Function (MF) lyase activity 1 Moderately Informative Inherited
Molecular Function (MF) enzyme activator activity 0.000000000001574 Informative Direct
Molecular Function (MF) phospholipid binding 0 Informative Direct
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.0000000007104 Informative Direct
Molecular Function (MF) enzyme binding 0.00000001392 Informative Direct
Molecular Function (MF) receptor binding 0.002876 Informative Inherited
Molecular Function (MF) phosphatase activity 1 Informative Inherited
Molecular Function (MF) carbon-carbon lyase activity 0.3953 Informative Inherited
Molecular Function (MF) GTPase regulator activity 0 Highly Informative Direct
Molecular Function (MF) phosphoric diester hydrolase activity 0 Highly Informative Direct
Molecular Function (MF) calcium ion binding 0 Highly Informative Direct
Molecular Function (MF) phospholipase activity 0 Highly Informative Direct
Molecular Function (MF) modified amino acid binding 0.0000000000001872 Highly Informative Direct
Molecular Function (MF) ubiquitin-like protein transferase activity 0.00001357 Highly Informative Direct
Molecular Function (MF) alcohol binding 0.00001825 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0.6409 Highly Informative Inherited
Molecular Function (MF) small GTPase binding 0.2805 Highly Informative Inherited
Molecular Function (MF) phosphatidylinositol bisphosphate binding 0.01184 Highly Informative Inherited
Molecular Function (MF) guanyl-nucleotide exchange factor activity 1 Highly Informative Inherited
Molecular Function (MF) phosphoprotein phosphatase activity 0.8287 Highly Informative Inherited
Molecular Function (MF) carboxy-lyase activity 0.04493 Highly Informative Inherited
Molecular Function (MF) transcription factor activity, transcription factor binding 0.06561 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.000000000000001616 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) macromolecular complex 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) vesicle 0 Moderately Informative Direct
Cellular Component (CC) bounding membrane of organelle 0.6097 Moderately Informative Inherited
Cellular Component (CC) whole membrane 0.9279 Moderately Informative Inherited
Cellular Component (CC) extracellular region part 1 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 0.8397 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) intrinsic component of membrane 1 Moderately Informative Inherited
Cellular Component (CC) transferase complex 0.02384 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.1772 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.05569 Moderately Informative Inherited
Cellular Component (CC) synapse 0 Informative Direct
Cellular Component (CC) extrinsic component of membrane 0 Informative Direct
Cellular Component (CC) cytoplasmic vesicle part 0.00000008151 Informative Direct
Cellular Component (CC) cytoplasmic region 0.0001261 Informative Direct
Cellular Component (CC) plasma membrane region 0.0001765 Informative Direct
Cellular Component (CC) extracellular organelle 0.0002205 Informative Direct
Cellular Component (CC) transferase complex, transferring phosphorus-containing groups 0.0003915 Informative Direct
Cellular Component (CC) side of membrane 0.7712 Informative Inherited
Cellular Component (CC) cell surface 1 Informative Inherited
Cellular Component (CC) extracellular space 0.5849 Informative Inherited
Cellular Component (CC) cilium 0.01532 Informative Inherited
Cellular Component (CC) plasma membrane bounded cell projection part 0.627 Informative Inherited
Cellular Component (CC) nuclear envelope 0.04056 Informative Inherited
Cellular Component (CC) endoplasmic reticulum membrane 1 Informative Inherited
Cellular Component (CC) secretory granule 0.01017 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 0.02734 Informative Inherited
Cellular Component (CC) synaptic vesicle 0 Highly Informative Direct
Cellular Component (CC) midbody 0.000001182 Highly Informative Direct
Cellular Component (CC) cytoplasmic vesicle membrane 0.000002403 Highly Informative Direct
Cellular Component (CC) symplast 0.000008025 Highly Informative Direct
Cellular Component (CC) nuclear membrane 0.000008663 Highly Informative Direct
Cellular Component (CC) cell division site part 0.0001204 Highly Informative Direct
Cellular Component (CC) microtubule organizing center 0.0004137 Highly Informative Direct
Cellular Component (CC) extracellular vesicle 1 Highly Informative Inherited
Cellular Component (CC) endocytic vesicle 1 Highly Informative Inherited
Cellular Component (CC) cell-substrate adherens junction 0.001843 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases1Moderately InformativeInherited
Enzyme Commission (EC)Carboxylic ester hydrolases1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0.005268Moderately InformativeInherited
Enzyme Commission (EC)Phosphoinositide phospholipase C0InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol 3-kinase0Highly InformativeDirect
Enzyme Commission (EC)Phospholipase A(2)0Highly InformativeDirect
Enzyme Commission (EC)Protein kinase C0Highly InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-4,5-bisphosphate 3-kinase0Highly InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-4-phosphate 3-kinase2.368e-16Highly InformativeDirect
Enzyme Commission (EC)Lysophospholipase0.000000000002869Highly InformativeDirect
Enzyme Commission (EC)Phospholipase D0.0002652Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.8721Least InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.167Moderately InformativeInherited
Phenotypic Abnormality (PA)Neoplasm by histology0.3869InformativeInherited
Phenotypic Abnormality (PA)Sarcoma0.06189Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.02477Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.1606Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.4797Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.8007Least InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.08472Moderately InformativeInherited
Mammalian Phenotype (MP)neoplasm0.1929Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal myeloid cell morphology0.1962Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.5879Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.5947Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.6098Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood coagulation0.005114InformativeInherited
Mammalian Phenotype (MP)abnormal ion homeostasis0.06105InformativeInherited
Mammalian Phenotype (MP)abnormal T cell physiology0.8139InformativeInherited
Mammalian Phenotype (MP)increased hamartoma incidence0.00144Highly InformativeInherited
Mammalian Phenotype (MP)abnormal synapse morphology0.001925Highly InformativeInherited
Mammalian Phenotype (MP)increased skin tumor incidence0.002963Highly InformativeInherited
Mammalian Phenotype (MP)abnormal platelet morphology0.009036Highly InformativeInherited
Mammalian Phenotype (MP)abnormal calcium ion homeostasis0.03211Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cytotoxic T cell physiology0.304Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.000002485Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0.00001619Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.00002461Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.004196Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.006946Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.0944Least InformativeInherited
Worm Phenotype (WP)protein expression variant0.000000007463Moderately InformativeDirect
Worm Phenotype (WP)chemical response variant0.0004508Moderately InformativeDirect
Worm Phenotype (WP)cell homeostasis metabolism variant0.02478Moderately InformativeInherited
Worm Phenotype (WP)feeding behavior variant0.05683Moderately InformativeInherited
Worm Phenotype (WP)cell component morphology variant0.202Moderately InformativeInherited
Worm Phenotype (WP)germ cell morphology variant0.2768Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.7746Moderately InformativeInherited
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.00000004561InformativeDirect
Worm Phenotype (WP)defecation variant0.00001637InformativeDirect
Worm Phenotype (WP)pharyngeal pumping variant0.00001988InformativeDirect
Worm Phenotype (WP)mitochondria morphology variant0.00003726InformativeDirect
Worm Phenotype (WP)growth rate variant0.00004258InformativeDirect
Worm Phenotype (WP)locomotor coordination variant0.0001048InformativeDirect
Worm Phenotype (WP)organism pathogen response variant0.0004581InformativeDirect
Worm Phenotype (WP)electrophysiology variant0.0005334InformativeDirect
Worm Phenotype (WP)drug resistant0.000929InformativeDirect
Worm Phenotype (WP)cell stress response variant0.002484InformativeInherited
Worm Phenotype (WP)pattern protein expression variant0.006909InformativeInherited
Worm Phenotype (WP)muscle cell physiology variant0.01042InformativeInherited
Worm Phenotype (WP)sexually dimorphic behavior variant0.02442InformativeInherited
Worm Phenotype (WP)localized movement variant0.02665InformativeInherited
Worm Phenotype (WP)foraging behavior variant0.08913InformativeInherited
Worm Phenotype (WP)oocyte morphology variant0.5638InformativeInherited
Worm Phenotype (WP)antimicrobial gene expression variant0.00000000005379Highly InformativeDirect
Worm Phenotype (WP)gonad sheath contractions variant0.000000001173Highly InformativeDirect
Worm Phenotype (WP)drug induced gene expression variant0.000000001655Highly InformativeDirect
Worm Phenotype (WP)response to injury variant0.0000001409Highly InformativeDirect
Worm Phenotype (WP)defecation contraction variant0.000000246Highly InformativeDirect
Worm Phenotype (WP)endomitotic oocytes0.0000003028Highly InformativeDirect
Worm Phenotype (WP)ovulation variant0.0000006442Highly InformativeDirect
Worm Phenotype (WP)osmotic stress response variant0.00001409Highly InformativeDirect
Worm Phenotype (WP)nose touch variant0.0000374Highly InformativeDirect
Worm Phenotype (WP)post hermaphrodite contact variant0.0001499Highly InformativeDirect
Worm Phenotype (WP)RNAi response variant0.0002324Highly InformativeDirect
Worm Phenotype (WP)male mating defective0.0002408Highly InformativeDirect
Worm Phenotype (WP)nose movement variant0.1114Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)pollen tube cell0.00007155InformativeDirect
Plant structure DEvelopment stage (PDE)pollen development stage0.00003916Moderately InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorus-containing groups4.944e-16Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Acyltransferases0.000003163Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0.003721Moderately InformativeInherited
Enzyme Commission (EC)Carbon-carbon lyases0.92Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases1Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric diester hydrolases0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0.00008399InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0.2097InformativeInherited
Enzyme Commission (EC)Carboxylic ester hydrolases1InformativeInherited
Enzyme Commission (EC)HECT-type E3 ubiquitin transferase0Highly InformativeDirect
Enzyme Commission (EC)Phosphoinositide phospholipase C0Highly InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0.0006872Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processDifferentiation0Moderately InformativeDirect
Biological processImmunity0Moderately InformativeDirect
Biological processLipid metabolism0Moderately InformativeDirect
Biological processUbl conjugation pathway0Moderately InformativeDirect
Biological processApoptosis4.844e-16Moderately InformativeDirect
Biological processAutophagy0InformativeDirect
Biological processEndocytosis0InformativeDirect
Biological processInflammatory response0InformativeDirect
Biological processLipid degradation0InformativeDirect
Biological processAngiogenesis0.00000000000003141InformativeDirect
Biological processLipid transport0.0000000000381InformativeDirect
Biological processCell adhesion0.000000001966InformativeDirect
Biological processChemotaxis0.00002461InformativeDirect
Biological processPlant defense0.0002906InformativeDirect
Biological processSensory transduction0.04269InformativeInherited
Biological processExocytosis0Highly InformativeDirect
Biological processAbscisic acid signaling pathway0Highly InformativeDirect
Biological processNeurotransmitter transport0.000000000000002388Highly InformativeDirect
Biological processFertilization0.0000000006864Highly InformativeDirect
Biological processPhagocytosis0.00000005316Highly InformativeDirect
Biological processGrowth regulation0.000004051Highly InformativeDirect
Biological processVision0.00007739Highly InformativeDirect
Biological processCilium biogenesis/degradation0.00009835Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentNucleus0.00000000009534Least InformativeDirect
Cellular componentCytoplasm0.1094Least InformativeInherited
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentEndosome0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0Moderately InformativeDirect
Cellular componentCytoskeleton0.00000000003483Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0.00000000009672Moderately InformativeDirect
Cellular componentGolgi apparatus0.0000022Moderately InformativeDirect
Cellular componentLysosome0.0000000004144InformativeDirect
Cellular componentSynapse0.00000003232InformativeDirect
Coding sequence diversityAlternative splicing0.0000000005489Least InformativeDirect
DiseaseTumor suppressor0.0005433Moderately InformativeDirect
DomainRepeat0Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainCoiled coil0.00000000001791Moderately InformativeDirect
DomainZinc-finger0.000000000308Moderately InformativeDirect
DomainSH2 domain0.000000000001383InformativeDirect
DomainSH3 domain0.00002904InformativeDirect
DomainSignal-anchor0.00007627InformativeDirect
DomainSH3-binding0.0004117InformativeDirect
Molecular functionMetal-binding0.000000001567Least InformativeDirect
Molecular functionZinc0.000000103Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionLipid-binding0Moderately InformativeDirect
Post-translational modificationHydrolase0.000006197Least InformativeDirect
Post-translational modificationTransferase0.226Least InformativeInherited
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0.0000152Moderately InformativeDirect
Post-translational modificationGTPase activation0InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0InformativeDirect
Post-translational modificationProtein phosphatase0.000000000000314InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor0.0000000003595InformativeDirect
Post-translational modificationChromatin regulator0.0002505InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)lipid metabolism0.002624Least InformativeInherited
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect
UniPathway (UP)phospholipid metabolism0InformativeDirect
UniPathway (UP)biological regulation0Highly InformativeDirect
UniPathway (UP)phosphatidylinositol phosphate biosynthesis0.00000000005349Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR008973 SSF49562 Protein matches
Abstract

The Ca2+-dependent, lipid-binding domain (CaLB) has been identified in a number of proteins, for example the amino-terminal, 138 amino acid C2 domain of cytosolic phospholipase A2 (cPLA2-C2) which mediates an initial step in the production of lipid mediators of inflammation: the Ca2+-dependent translocation of the enzyme to intracellular membranes with subsequent liberation of arachidonic acid. The domain is composed of eight antiparallel beta-strands with six interconnecting loops that fits the "type II" topology for C2 domains. The structure has been identified as a beta-sandwich in the "Greek key" motif [PubMed9665851].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 25 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a C2 domain (Calcium/lipid-binding domain, CaLB) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 25 hidden Markov models representing the C2 domain (Calcium/lipid-binding domain, CaLB) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]