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gamma-Crystallin-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   gamma-Crystallin-like [ 49694]
Superfamily:   gamma-Crystallin-like [ 49695] (6)
Families:   Crystallins/Ca-binding development proteins [ 49696] (4)
  Yeast killer toxin [ 49710]
  Streptomyces metalloproteinase inhibitor, SMPI [ 49713]
  Killer toxin-like protein SKLP [ 49716]
  Antifungal protein AFP1 [ 63693]
  Plant antimicrobial protein MIAMP1 [ 49719]

Superfamily statistics
Genomes (261) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 2,599 8,220 29
Proteins 2,047 6,715 28

Functional annotation
General category General
Detailed category Structural protein

Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.00001539Least InformativeDirect
Disease Ontology (DO)sensory system disease0.0000000005035Moderately InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the eye0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the head0.7369Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal globe morphology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the orbital region0.1899Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.7639Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lens0InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the uvea0.063InformativeInherited
Phenotypic Abnormality (PA)Abnormal cornea morphology0.6834InformativeInherited
Phenotypic Abnormality (PA)Cataract0Highly InformativeDirect
Phenotypic Abnormality (PA)Corneal dystrophy0.0000000251Highly InformativeDirect
Phenotypic Abnormality (PA)Microcornea0.000002332Highly InformativeDirect
Phenotypic Abnormality (PA)Corneal opacity0.00008262Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal eye morphology0.0000007703Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal anterior eye segment morphology0.00000000001673InformativeDirect
Mammalian Phenotype (MP)abnormal eye development0.1359InformativeInherited
Mammalian Phenotype (MP)abnormal lens morphology0.00000000000008658Highly InformativeDirect
Mammalian Phenotype (MP)microphthalmia0.000004295Highly InformativeDirect

Document: MP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)head0.6132Least InformativeInherited
Xenopus ANatomical entity (XAN)nervous system1Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ1Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.07184Moderately InformativeInherited
Xenopus ANatomical entity (XAN)sensory system0.0765Moderately InformativeInherited
Xenopus ANatomical entity (XAN)eye0.06521InformativeInherited
Xenopus DEvelopment stage (XDE)post-embryonic stage0.2268Least InformativeInherited
Xenopus DEvelopment stage (XDE)embryonic stage0.1157Moderately InformativeInherited
Xenopus DEvelopment stage (XDE)climax stage0.1224Moderately InformativeInherited
Xenopus DEvelopment stage (XDE)tailbud stage0.06972InformativeInherited
Xenopus DEvelopment stage (XDE)NF stage 620.00000446Highly InformativeDirect
Xenopus DEvelopment stage (XDE)early tailbud stage0.001442Highly InformativeInherited

Document: XA annotation of SCOP domains

InterPro annotation
Cross references IPR011024 SSF49695 Protein matches

This family contains proteins which have a Greek key motif [PubMed8506258]. They are all structurally related to the beta/gamma crystallin superfamily. This family of proteins includes:

  • Beta and gamma crystallins
  • Yeast killer toxin
  • Killer toxin-like protein SKLP
  • Antifungal protein, AFP1
  • Plant antimicrobial protein, MIAMP1
  • Streptomyces metalloproteinase inhibitor, SMPI [PubMed9735297].

Note: SMPI belongs to MEROPS inhibitor I36, clan IU. It inhibits members of the thermolysin family, MEROPS peptidase family M4, [PubMed14705960].

InterPro database

PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 25 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Browse and view proteins in genomes which have different domain combinations including a gamma-Crystallin-like domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 25 hidden Markov models representing the gamma-Crystallin-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · Internal database links ]