SUPERFAMILY 1.75 HMM library and genome assignments server

HSP20-like chaperones superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   HSP20-like chaperones [ 49763]
Superfamily:   HSP20-like chaperones [ 49764] (4)
Families:   HSP20 [ 49765]
  Co-chaperone p23-like [ 49768] (2)
  GS domain [ 101580] (2)
  Nuclear movement domain [ 117092] (2)


Superfamily statistics
Genomes (2,394) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 15,370 34,287 9
Proteins 15,110 34,018 9


Functional annotation
General category Processes_IC
Detailed category Protein modification

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus0.00000000000053610.0000165Least InformativeDirect
Biological Process (BP)protein metabolic process0.01150.0339Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.021640.3581Least InformativeInherited
Biological Process (BP)response to abiotic stimulus00Moderately InformativeDirect
Biological Process (BP)response to organic substance11Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.47340.5549Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.017850.000009177Moderately InformativeInherited
Biological Process (BP)response to light stimulus0.0000000031590.0000000000004982InformativeDirect
Biological Process (BP)response to inorganic substance0.0000003490.00000000000003411InformativeDirect
Biological Process (BP)response to oxidative stress0.00086270.000000001794InformativeDirect
Biological Process (BP)response to heat00Highly InformativeDirect
Biological Process (BP)protein folding0.0000000000000032510Highly InformativeDirect
Biological Process (BP)response to hydrogen peroxide0.000000061260Highly InformativeDirect
Biological Process (BP)response to endoplasmic reticulum stress0.0000083960.000002197Highly InformativeDirect
Biological Process (BP)response to topologically incorrect protein0.00048850.00008182Highly InformativeDirect
Molecular Function (MF)binding0.64540.7828Least InformativeInherited
Molecular Function (MF)unfolded protein binding00Highly InformativeDirect
Cellular Component (CC)non-membrane-bounded organelle0.046681Least InformativeInherited
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)contractile fiber part0.0000067320.00000001236InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0.0000165 Least Informative Direct
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.3581 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.0339 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) response to abiotic stimulus 0 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.000009177 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 0.01979 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 0.6033 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.01801 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.5094 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.5549 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.8984 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.9228 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.2339 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) response to light stimulus 0.0000000000004982 Informative Direct
Biological Process (BP) response to inorganic substance 0.00000000000003411 Informative Direct
Biological Process (BP) response to oxidative stress 0.000000001794 Informative Direct
Biological Process (BP) microtubule-based process 0.0001713 Informative Direct
Biological Process (BP) posttranscriptional regulation of gene expression 0.0003457 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0.003162 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 0.004816 Informative Inherited
Biological Process (BP) phosphorylation 0.7134 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.1395 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.06271 Informative Inherited
Biological Process (BP) carbohydrate biosynthetic process 0.1233 Informative Inherited
Biological Process (BP) polysaccharide metabolic process 0.1423 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 0.2905 Informative Inherited
Biological Process (BP) monocarboxylic acid biosynthetic process 0.006067 Informative Inherited
Biological Process (BP) fatty acid metabolic process 0.03981 Informative Inherited
Biological Process (BP) cellular component movement 0.6592 Informative Inherited
Biological Process (BP) localization of cell 0.3612 Informative Inherited
Biological Process (BP) locomotion 0.7681 Informative Inherited
Biological Process (BP) generation of neurons 0.9975 Informative Inherited
Biological Process (BP) response to heat 0 Highly Informative Direct
Biological Process (BP) protein folding 0 Highly Informative Direct
Biological Process (BP) response to hydrogen peroxide 0 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 0.000002197 Highly Informative Direct
Biological Process (BP) response to topologically incorrect protein 0.00008182 Highly Informative Direct
Biological Process (BP) fatty acid derivative biosynthetic process 0.000000803 Highly Informative Direct
Biological Process (BP) unsaturated fatty acid metabolic process 0.00001324 Highly Informative Direct
Biological Process (BP) icosanoid metabolic process 0.00002732 Highly Informative Direct
Biological Process (BP) microtubule-based movement 0.00006048 Highly Informative Direct
Biological Process (BP) regulation of protein stability 0.000126 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.0005052 Highly Informative Direct
Biological Process (BP) regulation of proteolysis involved in cellular protein catabolic process 0.003723 Highly Informative Inherited
Biological Process (BP) lipoprotein metabolic process 0.001351 Highly Informative Inherited
Biological Process (BP) regulation of translation 0.01386 Highly Informative Inherited
Biological Process (BP) protein phosphorylation 0.8092 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.09618 Highly Informative Inherited
Biological Process (BP) cellular polysaccharide biosynthetic process 0.009147 Highly Informative Inherited
Molecular Function (MF) binding 0.7828 Least Informative Inherited
Molecular Function (MF) structural molecule activity 0.1109 Moderately Informative Inherited
Molecular Function (MF) receptor binding 0.53 Informative Inherited
Molecular Function (MF) unfolded protein binding 0 Highly Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.4832 Least Informative Inherited
Cellular Component (CC) contractile fiber part 0.00000001236 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0.00119Least InformativeInherited
Enzyme Commission (EC)Acting on NADH or NADPH0.00000000003112Moderately InformativeDirect
Enzyme Commission (EC)With a heme protein as acceptor0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.03641Least InformativeInherited
Disease Ontology (DO)neuropathy0.0004733InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of muscle physiology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of muscle morphology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Distal muscle weakness0Highly InformativeDirect
Phenotypic Abnormality (PA)Hyporeflexia of lower limbs0Highly InformativeDirect
Phenotypic Abnormality (PA)EMG abnormality0Highly InformativeDirect
Phenotypic Abnormality (PA)Areflexia of lower limbs0.00000002335Highly InformativeDirect

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.0000002794Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.001885Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.6655Least InformativeInherited
Worm Phenotype (WP)protein aggregation variant0.000000000002481Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0.0000000003113Moderately InformativeDirect
Worm Phenotype (WP)endocytic transport defect0.05195Moderately InformativeInherited
Worm Phenotype (WP)life span variant0.000232InformativeDirect
Worm Phenotype (WP)metal response variant0.0005115InformativeDirect
Worm Phenotype (WP)organism pathogen response variant0.002029InformativeInherited
Worm Phenotype (WP)pathogen susceptibility increased0.0000001699Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0.005087Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases0.02819Least InformativeInherited
Enzyme Commission (EC)Hydrolases0.1836Least InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases0.0000934Moderately InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0.009904Moderately InformativeInherited
Enzyme Commission (EC)Isomerases0.06117Moderately InformativeInherited
Enzyme Commission (EC)Acting on NADH or NADPH0.00000000257InformativeDirect
Enzyme Commission (EC)Omega peptidases0.000002037InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0.001978InformativeInherited
Enzyme Commission (EC)With a heme protein as acceptor0Highly InformativeDirect
Enzyme Commission (EC)Other intramolecular oxidoreductases0.00000000008769Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation0.01577Moderately InformativeInherited
Biological processCell cycle0.501Moderately InformativeInherited
Biological processLipid metabolism0.7853Moderately InformativeInherited
Biological processStress response0InformativeDirect
Biological processUbl conjugation pathway0.0000002557InformativeDirect
Biological processPlant defense0.000008169InformativeDirect
Biological processMitosis0.00002128InformativeDirect
Biological processNeurogenesis0.00003992InformativeDirect
Biological processLipid biosynthesis0.2463InformativeInherited
Biological processSpermatogenesis0.0000001278Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentEndoplasmic reticulum0.0000004187Moderately InformativeDirect
Cellular componentCytoskeleton0.0007275Moderately InformativeDirect
Cellular componentMicrotubule0.00009724InformativeDirect
DomainTransit peptide0.0008471Moderately InformativeDirect
DomainTPR repeat0.0000000000004042Highly InformativeDirect
Molecular functionZinc0Least InformativeDirect
Post-translational modificationChaperone0InformativeDirect
Post-translational modificationEye lens protein0Highly InformativeDirect
Post-translational modificationAcetylation0Least InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationMethylation0Moderately InformativeDirect
Post-translational modificationOxidation0Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)lipid metabolism0Least InformativeDirect
UniPathway (UP)fatty acid metabolism0Moderately InformativeDirect
UniPathway (UP)lipid biosynthesis0Moderately InformativeDirect
UniPathway (UP)fatty acid biosynthesis0InformativeDirect
UniPathway (UP)prostaglandin biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR008978 SSF49764 Protein matches
Abstract

Hsp20 is a mammalian small heat-shock protein family that occurs most abundantly in skeletal muscle and heart. It has a tendency to form dimers, via a disulphide linkage formed by an N-terminal cysteine, low heat stability and a poor chaperoning ability in comparison with other family members. Structurally, this and related proteins contain a beta-sandwich fold consisting of 8 strands in 2 beta-sheets in a greek-key topology [PubMed11702068].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 8 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a HSP20-like chaperones domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 8 hidden Markov models representing the HSP20-like chaperones superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]