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HSP20-like chaperones superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   HSP20-like chaperones [ 49763]
Superfamily:   HSP20-like chaperones [ 49764] (4)
Families:   HSP20 [ 49765]
  Co-chaperone p23-like [ 49768] (2)
  GS domain [ 101580] (2)
  Nuclear movement domain [ 117092] (2)


Superfamily statistics
Genomes (2,402) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 15,640 66,881 9
Proteins 15,337 66,074 9


Functional annotation
General category Processes_IC
Detailed category Protein modification

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0.00119Least InformativeInherited
Enzyme Commission (EC)Acting on NADH or NADPH0.00000000003112Moderately InformativeDirect
Enzyme Commission (EC)With a heme protein as acceptor0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.0447Least InformativeInherited
Disease Ontology (DO)peripheral nervous system disease0.000001021InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of limbs0.1119Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature0.2732Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.5343Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.04684Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.1119Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature of the limbs0.0003096InformativeDirect
Phenotypic Abnormality (PA)Muscle weakness0.007841InformativeInherited
Phenotypic Abnormality (PA)Abnormal reflex0.01934InformativeInherited
Phenotypic Abnormality (PA)Areflexia0.1638Highly InformativeInherited

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval growth variant0Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.000000000001841Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.0000007325Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.005277Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.4625Least InformativeInherited
Worm Phenotype (WP)protein protein interaction variant0.00000000002066Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0.0000000001882Moderately InformativeDirect
Worm Phenotype (WP)movement variant0.0003211Moderately InformativeDirect
Worm Phenotype (WP)metal response variant0.002572InformativeInherited
Worm Phenotype (WP)endocytic transport defect0.06374InformativeInherited
Worm Phenotype (WP)organism pathogen response variant0.1011InformativeInherited
Worm Phenotype (WP)pathogen susceptibility increased0.00000705Highly InformativeDirect
Worm Phenotype (WP)cadmium hypersensitive0.000007963Highly InformativeDirect
Worm Phenotype (WP)peptide uptake by intestinal cell variant0.000829Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)nervous system0Least InformativeDirect
Zebrafish Anatomy (ZA)organism subdivision0Least InformativeDirect
Zebrafish Anatomy (ZA)head0Moderately InformativeDirect
Zebrafish Anatomy (ZA)portion of tissue0Moderately InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)tissue0.04912Least InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.0004732Moderately InformativeDirect
Xenopus ANatomical entity (XAN)skeletal muscle0.0001943InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0.005663Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases0.02655Least InformativeInherited
Enzyme Commission (EC)Hydrolases0.1944Least InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases0.00008566Moderately InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0.008959Moderately InformativeInherited
Enzyme Commission (EC)Isomerases0.05582Moderately InformativeInherited
Enzyme Commission (EC)Acting on NADH or NADPH0.000000002509InformativeDirect
Enzyme Commission (EC)Omega peptidases0.00000206InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0.001701InformativeInherited
Enzyme Commission (EC)With a heme protein as acceptor0Highly InformativeDirect
Enzyme Commission (EC)Other intramolecular oxidoreductases0.0000000001174Highly InformativeDirect

Document: EC annotation of SCOP domains

InterPro annotation
Cross references IPR008978 SSF49764 Protein matches
Abstract

Hsp20 is a mammalian small heat-shock protein family that occurs most abundantly in skeletal muscle and heart. It has a tendency to form dimers, via a disulphide linkage formed by an N-terminal cysteine, low heat stability and a poor chaperoning ability in comparison with other family members. Structurally, this and related proteins contain a beta-sandwich fold consisting of 8 strands in 2 beta-sheets in a greek-key topology [PubMed11702068].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 18 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a HSP20-like chaperones domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 18 hidden Markov models representing the HSP20-like chaperones superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]