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HSP20-like chaperones superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   HSP20-like chaperones [ 49763]
Superfamily:   HSP20-like chaperones [ 49764] (4)
Families:   HSP20 [ 49765]
  Co-chaperone p23-like [ 49768] (2)
  GS domain [ 101580] (2)
  Nuclear movement domain [ 117092] (2)


Superfamily statistics
Genomes (2,395) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 15,371 34,287 9
Proteins 15,106 34,018 9


Functional annotation
General category Processes_IC
Detailed category Protein modification

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus0.0000000000001620.0003428Least InformativeDirect
Biological Process (BP)response to stress00Moderately InformativeDirect
Biological Process (BP)response to abiotic stimulus00Moderately InformativeDirect
Biological Process (BP)response to organic substance0.86610.9333Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.12250.4384Moderately InformativeInherited
Biological Process (BP)response to temperature stimulus00InformativeDirect
Biological Process (BP)response to inorganic substance0.00025820.0001174InformativeDirect
Biological Process (BP)response to radiation11InformativeInherited
Biological Process (BP)response to oxidative stress0.022440.01262InformativeInherited
Biological Process (BP)protein folding0.000000000023080Highly InformativeDirect
Biological Process (BP)response to heat00Highly InformativeDirect
Biological Process (BP)response to hydrogen peroxide0.0000029850.000000000278Highly InformativeDirect
Biological Process (BP)response to arsenic-containing substance0.000026610.00000001693Highly InformativeDirect
Molecular Function (MF)binding0.08250.1469Least InformativeInherited
Molecular Function (MF)protein binding0.00054340.000003882Moderately InformativeDirect
Cellular Component (CC)non-membrane-bounded organelle0.08180.8735Least InformativeInherited
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)contractile fiber part0.0000096320.000000005753Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0.0003428 Least Informative Direct
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.595 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stress 0 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 0 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0.5673 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.003363 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.05303 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.5244 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.1206 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.006286 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.9333 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.6786 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.9778 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.8356 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 0.08968 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 1 Moderately Informative Inherited
Biological Process (BP) system development 1 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.4384 Moderately Informative Inherited
Biological Process (BP) fatty acid metabolic process 0.0003565 Informative Direct
Biological Process (BP) microtubule-based process 0.0002393 Informative Direct
Biological Process (BP) response to temperature stimulus 0 Informative Direct
Biological Process (BP) regulation of catabolic process 0.0008642 Informative Direct
Biological Process (BP) response to inorganic substance 0.0001174 Informative Direct
Biological Process (BP) monocarboxylic acid biosynthetic process 0.0000106 Informative Direct
Biological Process (BP) cytoskeleton organization 0.01228 Informative Inherited
Biological Process (BP) organelle assembly 0.02246 Informative Inherited
Biological Process (BP) regulation of proteolysis 0.004668 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 0.1395 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 0.02016 Informative Inherited
Biological Process (BP) regulation of system process 0.04775 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.06118 Informative Inherited
Biological Process (BP) regulation of cellular amide metabolic process 0.08642 Informative Inherited
Biological Process (BP) phosphorylation 0.6788 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.1009 Informative Inherited
Biological Process (BP) regulation of cell cycle 0.1329 Informative Inherited
Biological Process (BP) response to radiation 1 Informative Inherited
Biological Process (BP) movement of cell or subcellular component 0.7044 Informative Inherited
Biological Process (BP) locomotion 0.849 Informative Inherited
Biological Process (BP) generation of neurons 0.6875 Informative Inherited
Biological Process (BP) response to oxidative stress 0.01262 Informative Inherited
Biological Process (BP) protein folding 0 Highly Informative Direct
Biological Process (BP) microtubule-based movement 0.0001219 Highly Informative Direct
Biological Process (BP) response to heat 0 Highly Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0.000232 Highly Informative Direct
Biological Process (BP) regulation of protein stability 0.0001164 Highly Informative Direct
Biological Process (BP) lipoprotein metabolic process 0.00003335 Highly Informative Direct
Biological Process (BP) regulation of protein catabolic process 0.00003641 Highly Informative Direct
Biological Process (BP) response to hydrogen peroxide 0.000000000278 Highly Informative Direct
Biological Process (BP) response to arsenic-containing substance 0.00000001693 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.000004189 Highly Informative Direct
Biological Process (BP) establishment of organelle localization 0.1207 Highly Informative Inherited
Biological Process (BP) cell projection organization 0.9889 Highly Informative Inherited
Biological Process (BP) microtubule cytoskeleton organization 0.001943 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.03193 Highly Informative Inherited
Biological Process (BP) cell migration 0.3882 Highly Informative Inherited
Molecular Function (MF) binding 0.1469 Least Informative Inherited
Molecular Function (MF) protein binding 0.000003882 Moderately Informative Direct
Molecular Function (MF) lyase activity 0.333 Moderately Informative Inherited
Molecular Function (MF) structural molecule activity 0.254 Moderately Informative Inherited
Molecular Function (MF) identical protein binding 0.00005585 Informative Direct
Molecular Function (MF) receptor binding 0.7817 Informative Inherited
Molecular Function (MF) hydro-lyase activity 0.002212 Informative Inherited
Molecular Function (MF) chaperone binding 0.0000612 Highly Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0.8735 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.03016 Least Informative Inherited
Cellular Component (CC) contractile fiber part 0.000000005753 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0.00119Least InformativeInherited
Enzyme Commission (EC)Acting on NADH or NADPH0.00000000003112Moderately InformativeDirect
Enzyme Commission (EC)With a heme protein as acceptor0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.04479Least InformativeInherited
Disease Ontology (DO)peripheral nervous system disease0.0000009918InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Pace of progression0.01722Moderately InformativeInherited
Slow progression0.00005305InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the musculature0.06793Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.1072Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.1387Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.2206Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the hand0.03651Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle physiology0.0366Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digit0.04467Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle morphology0.1437Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.2976Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the foot0.6738Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature of the upper limbs0.002206InformativeInherited
Phenotypic Abnormality (PA)Gait disturbance0.05863InformativeInherited
Phenotypic Abnormality (PA)Abnormality of toe0.06233InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle size0.1753InformativeInherited
Phenotypic Abnormality (PA)Distal muscle weakness0.000009325Highly InformativeDirect
Phenotypic Abnormality (PA)Limb muscle weakness0.000009325Highly InformativeDirect
Phenotypic Abnormality (PA)Hyporeflexia0.000299Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the hallux0.0004954Highly InformativeDirect
Phenotypic Abnormality (PA)Areflexia0.2075Highly InformativeInherited

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval growth variant0Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.000000000001264Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.0000003028Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.006512Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.6069Least InformativeInherited
Worm Phenotype (WP)protein protein interaction variant0.00000000001812Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0.000000000184Moderately InformativeDirect
Worm Phenotype (WP)movement variant0.0003875Moderately InformativeDirect
Worm Phenotype (WP)organism stress response variant0.03889Moderately InformativeInherited
Worm Phenotype (WP)metal response variant0.001722InformativeInherited
Worm Phenotype (WP)organism pathogen response variant0.009648InformativeInherited
Worm Phenotype (WP)endocytic transport defect0.06245InformativeInherited
Worm Phenotype (WP)pathogen susceptibility increased0.000004103Highly InformativeDirect
Worm Phenotype (WP)cadmium hypersensitive0.000008116Highly InformativeDirect
Worm Phenotype (WP)peptide uptake by intestinal cell variant0.0007307Highly InformativeDirect
Worm Phenotype (WP)organism temperature response variant0.006883Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)nervous system0Least InformativeDirect
Zebrafish Anatomy (ZA)organism subdivision0Least InformativeDirect
Zebrafish Anatomy (ZA)head0Moderately InformativeDirect
Zebrafish Anatomy (ZA)portion of tissue0Moderately InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)tissue0.07479Least InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.001473Moderately InformativeInherited
Xenopus ANatomical entity (XAN)skeletal muscle0.0002786InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0.005524Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases0.02672Least InformativeInherited
Enzyme Commission (EC)Hydrolases0.1918Least InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases0.00008993Moderately InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0.008926Moderately InformativeInherited
Enzyme Commission (EC)Isomerases0.0586Moderately InformativeInherited
Enzyme Commission (EC)Acting on NADH or NADPH0.00000000271InformativeDirect
Enzyme Commission (EC)Omega peptidases0.000002044InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0.001852InformativeInherited
Enzyme Commission (EC)With a heme protein as acceptor0Highly InformativeDirect
Enzyme Commission (EC)Other intramolecular oxidoreductases0.0000000001081Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processUbl conjugation pathway0.000000392Moderately InformativeDirect
Biological processDifferentiation0.02086Moderately InformativeInherited
Biological processCell cycle0.5147Moderately InformativeInherited
Biological processStress response0InformativeDirect
Biological processMitosis0.00002981InformativeDirect
Biological processPlant defense0.0000346InformativeDirect
Biological processNeurogenesis0.00007057InformativeDirect
Biological processSpermatogenesis0.0000002481Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentEndoplasmic reticulum0.00000106Moderately InformativeDirect
Cellular componentMicrotubule0.0001446InformativeDirect
DomainTPR repeat0.0000000000005818Highly InformativeDirect
Molecular functionZinc0Least InformativeDirect
Post-translational modificationChaperone0InformativeDirect
Post-translational modificationEye lens protein0Highly InformativeDirect
Post-translational modificationAcetylation0Least InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationMethylation0Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)lipid metabolism0Least InformativeDirect
UniPathway (UP)fatty acid metabolism0Moderately InformativeDirect
UniPathway (UP)lipid biosynthesis0Moderately InformativeDirect
UniPathway (UP)fatty acid biosynthesis0InformativeDirect
UniPathway (UP)prostaglandin biosynthesis0.000009609Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR008978 SSF49764 Protein matches
Abstract

Hsp20 is a mammalian small heat-shock protein family that occurs most abundantly in skeletal muscle and heart. It has a tendency to form dimers, via a disulphide linkage formed by an N-terminal cysteine, low heat stability and a poor chaperoning ability in comparison with other family members. Structurally, this and related proteins contain a beta-sandwich fold consisting of 8 strands in 2 beta-sheets in a greek-key topology [PubMed11702068].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 8 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a HSP20-like chaperones domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 8 hidden Markov models representing the HSP20-like chaperones superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]