SUPERFAMILY 1.75 HMM library and genome assignments server


HSP20-like chaperones superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   HSP20-like chaperones [ 49763]
Superfamily:   HSP20-like chaperones [ 49764] (4)
Families:   HSP20 [ 49765]
  Co-chaperone p23-like [ 49768] (2)
  GS domain [ 101580] (2)
  Nuclear movement domain [ 117092] (2)


Superfamily statistics
Genomes (2,385) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 14,746 34,287 9
Proteins 14,509 34,018 9


Functional annotation
General category Processes_IC
Detailed category Protein modification

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus1.567e-133.199e-06Least InformativeDirect
Biological Process (BP)single-organism cellular process0.72681Least InformativeInherited
Biological Process (BP)protein metabolic process0.02040.03484Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.035920.3762Least InformativeInherited
Biological Process (BP)response to abiotic stimulus00Moderately InformativeDirect
Biological Process (BP)response to organic substance0.98151Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.47430.5247Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.0092967.476e-06Moderately InformativeInherited
Biological Process (BP)response to oxidative stress0.0009068.189e-10InformativeDirect
Biological Process (BP)response to light stimulus2.709e-093.211e-13InformativeDirect
Biological Process (BP)response to inorganic substance1.087e-062.349e-13InformativeDirect
Biological Process (BP)protein folding3.947e-140Highly InformativeDirect
Biological Process (BP)response to heat00Highly InformativeDirect
Biological Process (BP)response to endoplasmic reticulum stress9.389e-061.621e-06Highly InformativeDirect
Biological Process (BP)response to topologically incorrect protein0.00059229.204e-05Highly InformativeDirect
Biological Process (BP)response to hydrogen peroxide6.144e-090Highly InformativeDirect
Molecular Function (MF)binding0.67330.917Least InformativeInherited
Molecular Function (MF)unfolded protein binding00Highly InformativeDirect
Cellular Component (CC)intracellular non-membrane-bounded organelle0.032331Least InformativeInherited
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)contractile fiber part6.359e-067.824e-09InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 3.199e-06 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.3762 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.03484 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) response to abiotic stimulus 0 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 0.0003219 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 7.476e-06 Moderately Informative Direct
Biological Process (BP) cellular component biogenesis 0.01949 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.1284 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.5247 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.7874 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.908 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) lipid biosynthetic process 0.3101 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) single-organism biosynthetic process 0.7389 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.3472 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 0.8765 Moderately Informative Inherited
Biological Process (BP) response to oxidative stress 8.189e-10 Informative Direct
Biological Process (BP) microtubule-based process 0.000133 Informative Direct
Biological Process (BP) response to light stimulus 3.211e-13 Informative Direct
Biological Process (BP) response to inorganic substance 2.349e-13 Informative Direct
Biological Process (BP) posttranscriptional regulation of gene expression 0.0002742 Informative Direct
Biological Process (BP) regulation of response to stress 0.07133 Informative Inherited
Biological Process (BP) protein complex assembly 0.03729 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 0.008144 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 0.00107 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.07796 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.0655 Informative Inherited
Biological Process (BP) phosphorylation 1 Informative Inherited
Biological Process (BP) polysaccharide metabolic process 0.1359 Informative Inherited
Biological Process (BP) carbohydrate biosynthetic process 0.1169 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 0.2765 Informative Inherited
Biological Process (BP) cellular component movement 0.6419 Informative Inherited
Biological Process (BP) locomotion 0.7478 Informative Inherited
Biological Process (BP) generation of neurons 0.979 Informative Inherited
Biological Process (BP) localization of cell 0.3402 Informative Inherited
Biological Process (BP) fatty acid metabolic process 0.0351 Informative Inherited
Biological Process (BP) monocarboxylic acid biosynthetic process 0.004979 Informative Inherited
Biological Process (BP) protein folding 0 Highly Informative Direct
Biological Process (BP) icosanoid metabolic process 2.666e-05 Highly Informative Direct
Biological Process (BP) microtubule-based movement 6.557e-05 Highly Informative Direct
Biological Process (BP) response to heat 0 Highly Informative Direct
Biological Process (BP) regulation of proteolysis 0.0001817 Highly Informative Direct
Biological Process (BP) regulation of protein stability 0.0001086 Highly Informative Direct
Biological Process (BP) unsaturated fatty acid metabolic process 1.265e-05 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 1.621e-06 Highly Informative Direct
Biological Process (BP) response to topologically incorrect protein 9.204e-05 Highly Informative Direct
Biological Process (BP) regulation of protein catabolic process 0.0001592 Highly Informative Direct
Biological Process (BP) response to hydrogen peroxide 0 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.0002643 Highly Informative Direct
Biological Process (BP) fatty acid derivative biosynthetic process 7.849e-07 Highly Informative Direct
Biological Process (BP) regulation of translation 0.01305 Highly Informative Inherited
Biological Process (BP) protein phosphorylation 0.9533 Highly Informative Inherited
Biological Process (BP) cellular polysaccharide biosynthetic process 0.008555 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.09279 Highly Informative Inherited
Biological Process (BP) lipoprotein metabolic process 0.001286 Highly Informative Inherited
Molecular Function (MF) binding 0.917 Least Informative Inherited
Molecular Function (MF) structural molecule activity 0.1054 Moderately Informative Inherited
Molecular Function (MF) receptor binding 0.4545 Informative Inherited
Molecular Function (MF) unfolded protein binding 0 Highly Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.8675 Least Informative Inherited
Cellular Component (CC) contractile fiber part 7.824e-09 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0.00119Least InformativeInherited
Enzyme Commission (EC)Acting on NADH or NADPH3.112e-11Moderately InformativeDirect
Enzyme Commission (EC)With a heme protein as acceptor0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.04481Least InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of muscle physiology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of muscle morphology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Distal muscle weakness0Highly InformativeDirect
Phenotypic Abnormality (PA)Hyporeflexia of lower limbs0Highly InformativeDirect
Phenotypic Abnormality (PA)EMG abnormality0Highly InformativeDirect
Phenotypic Abnormality (PA)Areflexia of lower limbs2.267e-08Highly InformativeDirect

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant2.794e-07Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.001885Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.6655Least InformativeInherited
Worm Phenotype (WP)protein aggregation variant2.481e-12Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant3.113e-10Moderately InformativeDirect
Worm Phenotype (WP)endocytic transport defect0.05195Moderately InformativeInherited
Worm Phenotype (WP)life span variant0.000232InformativeDirect
Worm Phenotype (WP)metal response variant0.0005115InformativeDirect
Worm Phenotype (WP)organism pathogen response variant0.002029InformativeInherited
Worm Phenotype (WP)pathogen susceptibility increased1.699e-07Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0.005014Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases0.02795Least InformativeInherited
Enzyme Commission (EC)Hydrolases0.1812Least InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases9.44e-05Moderately InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0.01011Moderately InformativeInherited
Enzyme Commission (EC)Isomerases0.06128Moderately InformativeInherited
Enzyme Commission (EC)Acting on NADH or NADPH2.581e-09InformativeDirect
Enzyme Commission (EC)Omega peptidases2.036e-06InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0.001992InformativeInherited
Enzyme Commission (EC)With a heme protein as acceptor0Highly InformativeDirect
Enzyme Commission (EC)Other intramolecular oxidoreductases8.887e-11Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation0.01521Moderately InformativeInherited
Biological processCell cycle0.5172Moderately InformativeInherited
Biological processLipid metabolism0.7798Moderately InformativeInherited
Biological processStress response0InformativeDirect
Biological processUbl conjugation pathway2.556e-07InformativeDirect
Biological processPlant defense7.954e-06InformativeDirect
Biological processMitosis2.431e-05InformativeDirect
Biological processNeurogenesis3.924e-05InformativeDirect
Biological processLipid biosynthesis0.2454InformativeInherited
Biological processSpermatogenesis1.245e-07Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentEndoplasmic reticulum3.794e-07Moderately InformativeDirect
Cellular componentCytoskeleton0.0006762Moderately InformativeDirect
Cellular componentMicrotubule9.881e-05InformativeDirect
DomainTransit peptide0.0008404Moderately InformativeDirect
DomainTPR repeat4.089e-13Highly InformativeDirect
Molecular functionZinc0Least InformativeDirect
Post-translational modificationChaperone0InformativeDirect
Post-translational modificationEye lens protein0Highly InformativeDirect
Post-translational modificationAcetylation0Least InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationMethylation0Moderately InformativeDirect
Post-translational modificationOxidation0Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)lipid metabolism0Least InformativeDirect
UniPathway (UP)fatty acid metabolism0Moderately InformativeDirect
UniPathway (UP)lipid biosynthesis0Moderately InformativeDirect
UniPathway (UP)fatty acid biosynthesis0InformativeDirect
UniPathway (UP)prostaglandin biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR008978 SSF49764 Protein matches
Abstract

Hsp20 is a mammalian small heat-shock protein family that occurs most abundantly in skeletal muscle and heart. It has a tendency to form dimers, via a disulphide linkage formed by an N-terminal cysteine, low heat stability and a poor chaperoning ability in comparison with other family members. Structurally, this and related proteins contain a beta-sandwich fold consisting of 8 strands in 2 beta-sheets in a greek-key topology [PubMed11702068].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 8 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a HSP20-like chaperones domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 8 hidden Markov models representing the HSP20-like chaperones superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]