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HSP20-like chaperones superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   HSP20-like chaperones [ 49763]
Superfamily:   HSP20-like chaperones [ 49764] (4)
Families:   HSP20 [ 49765]
  Co-chaperone p23-like [ 49768] (2)
  GS domain [ 101580] (2)
  Nuclear movement domain [ 117092] (2)


Superfamily statistics
Genomes (2,396) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 15,455 34,287 9
Proteins 15,169 34,018 9


Functional annotation
General category Processes_IC
Detailed category Protein modification

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus0.000000000015720.006489Least InformativeInherited
Biological Process (BP)response to abiotic stimulus00Moderately InformativeDirect
Biological Process (BP)response to oxygen-containing compound0.091160.4741Moderately InformativeInherited
Biological Process (BP)response to organic substance0.80761Moderately InformativeInherited
Biological Process (BP)response to temperature stimulus00InformativeDirect
Biological Process (BP)response to radiation11InformativeInherited
Biological Process (BP)response to oxidative stress0.014740.007781InformativeInherited
Biological Process (BP)protein folding0.000000000000020020Highly InformativeDirect
Biological Process (BP)response to heat00Highly InformativeDirect
Biological Process (BP)response to hydrogen peroxide0.00000068680.0000000000543Highly InformativeDirect
Molecular Function (MF)binding0.039280.09361Least InformativeInherited
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)non-membrane-bounded organelle0.099730.9592Least InformativeInherited
Cellular Component (CC)supramolecular polymer0.000038180.000001112InformativeDirect
Cellular Component (CC)contractile fiber part0.000012180.000000001002Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) organic substance biosynthetic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.2985 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.006489 Least Informative Inherited
Biological Process (BP) cellular biosynthetic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) response to abiotic stimulus 0 Moderately Informative Direct
Biological Process (BP) cellular component assembly 0.00007357 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 0.0000246 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.8019 Moderately Informative Inherited
Biological Process (BP) nitrogen compound transport 0.5301 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.8834 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 0.109 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.08628 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.8986 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.8539 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.0578 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.4741 Moderately Informative Inherited
Biological Process (BP) protein complex biogenesis 0.008644 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.6664 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.7699 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) single-organism transport 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.5859 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.565 Moderately Informative Inherited
Biological Process (BP) system development 1 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 1 Moderately Informative Inherited
Biological Process (BP) fatty acid metabolic process 0.0003358 Informative Direct
Biological Process (BP) microtubule-based process 0.00000001676 Informative Direct
Biological Process (BP) response to temperature stimulus 0 Informative Direct
Biological Process (BP) monocarboxylic acid biosynthetic process 0.00001055 Informative Direct
Biological Process (BP) regulation of catabolic process 0.002847 Informative Inherited
Biological Process (BP) regulation of proteolysis 0.01565 Informative Inherited
Biological Process (BP) movement of cell or subcellular component 0.1484 Informative Inherited
Biological Process (BP) intracellular protein transport 0.08511 Informative Inherited
Biological Process (BP) organelle assembly 0.005848 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.01197 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.2824 Informative Inherited
Biological Process (BP) cellular protein complex assembly 0.09695 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.07676 Informative Inherited
Biological Process (BP) regulation of system process 0.05146 Informative Inherited
Biological Process (BP) regulation of cell cycle 0.1759 Informative Inherited
Biological Process (BP) response to radiation 1 Informative Inherited
Biological Process (BP) single-organism intracellular transport 0.01729 Informative Inherited
Biological Process (BP) organelle localization 0.2651 Informative Inherited
Biological Process (BP) locomotion 0.9155 Informative Inherited
Biological Process (BP) generation of neurons 0.7627 Informative Inherited
Biological Process (BP) response to oxidative stress 0.007781 Informative Inherited
Biological Process (BP) protein folding 0 Highly Informative Direct
Biological Process (BP) microtubule-based movement 0.0000000006691 Highly Informative Direct
Biological Process (BP) response to heat 0 Highly Informative Direct
Biological Process (BP) regulation of protein stability 0.00000005497 Highly Informative Direct
Biological Process (BP) regulation of microtubule-based process 0.00001706 Highly Informative Direct
Biological Process (BP) response to hydrogen peroxide 0.0000000000543 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.000006157 Highly Informative Direct
Biological Process (BP) regulation of proteolysis involved in cellular protein catabolic process 0.0000618 Highly Informative Direct
Biological Process (BP) microtubule cytoskeleton organization 0.09226 Highly Informative Inherited
Biological Process (BP) cell projection organization 0.5564 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.03645 Highly Informative Inherited
Biological Process (BP) establishment of organelle localization 0.1453 Highly Informative Inherited
Molecular Function (MF) binding 0.09361 Least Informative Inherited
Molecular Function (MF) lyase activity 0.3637 Moderately Informative Inherited
Molecular Function (MF) structural molecule activity 0.3632 Moderately Informative Inherited
Molecular Function (MF) identical protein binding 0.00000003215 Informative Direct
Molecular Function (MF) protein dimerization activity 0.0004112 Informative Direct
Molecular Function (MF) receptor binding 0.8492 Informative Inherited
Molecular Function (MF) hydro-lyase activity 0.002676 Informative Inherited
Molecular Function (MF) chaperone binding 0.00001005 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.9592 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.01993 Least Informative Inherited
Cellular Component (CC) supramolecular polymer 0.000001112 Informative Direct
Cellular Component (CC) contractile fiber part 0.000000001002 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0.00119Least InformativeInherited
Enzyme Commission (EC)Acting on NADH or NADPH0.00000000003112Moderately InformativeDirect
Enzyme Commission (EC)With a heme protein as acceptor0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.04413Least InformativeInherited
Disease Ontology (DO)peripheral nervous system disease0.000001009InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Pace of progression0.01762Moderately InformativeInherited
Slow progression0.00005777InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the musculature0.06702Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.1068Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.1397Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.1983Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle physiology0.03439Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the hand0.03711Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digit0.04488Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle morphology0.1479Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.3185Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the foot0.6686Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature of the limbs0.0004654InformativeDirect
Phenotypic Abnormality (PA)Gait disturbance0.0594InformativeInherited
Phenotypic Abnormality (PA)Abnormality of toe0.06377InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal muscles0.08559InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle size0.1758InformativeInherited
Phenotypic Abnormality (PA)Distal muscle weakness0.000009734Highly InformativeDirect
Phenotypic Abnormality (PA)Limb muscle weakness0.000009734Highly InformativeDirect
Phenotypic Abnormality (PA)Hyporeflexia0.000329Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the hallux0.0005131Highly InformativeDirect
Phenotypic Abnormality (PA)Areflexia0.2053Highly InformativeInherited

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval growth variant0Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.000000000001339Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.0000003355Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.007048Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.6151Least InformativeInherited
Worm Phenotype (WP)protein protein interaction variant0.00000000002088Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0.00000000019Moderately InformativeDirect
Worm Phenotype (WP)movement variant0.0003891Moderately InformativeDirect
Worm Phenotype (WP)organism stress response variant0.04072Moderately InformativeInherited
Worm Phenotype (WP)endocytic transport variant0.06709Moderately InformativeInherited
Worm Phenotype (WP)metal response variant0.002508InformativeInherited
Worm Phenotype (WP)organism pathogen response variant0.00979InformativeInherited
Worm Phenotype (WP)endocytic transport defect0.06376InformativeInherited
Worm Phenotype (WP)pathogen susceptibility increased0.000004681Highly InformativeDirect
Worm Phenotype (WP)cadmium hypersensitive0.000008306Highly InformativeDirect
Worm Phenotype (WP)peptide uptake by intestinal cell variant0.0008242Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)nervous system0Least InformativeDirect
Zebrafish Anatomy (ZA)organism subdivision0Least InformativeDirect
Zebrafish Anatomy (ZA)head0Moderately InformativeDirect
Zebrafish Anatomy (ZA)portion of tissue0Moderately InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)tissue0.0776Least InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.001515Moderately InformativeInherited
Xenopus ANatomical entity (XAN)skeletal muscle0.0002731InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0.005706Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases0.02567Least InformativeInherited
Enzyme Commission (EC)Hydrolases0.1881Least InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases0.00008563Moderately InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0.009129Moderately InformativeInherited
Enzyme Commission (EC)Isomerases0.0567Moderately InformativeInherited
Enzyme Commission (EC)Acting on NADH or NADPH0.000000002568InformativeDirect
Enzyme Commission (EC)Omega peptidases0.000001994InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0.001738InformativeInherited
Enzyme Commission (EC)With a heme protein as acceptor0Highly InformativeDirect
Enzyme Commission (EC)Other intramolecular oxidoreductases0.0000000001045Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processUbl conjugation pathway0.0000004128Moderately InformativeDirect
Biological processDifferentiation0.02275Moderately InformativeInherited
Biological processCell cycle0.5113Moderately InformativeInherited
Biological processStress response0InformativeDirect
Biological processMitosis0.00003042InformativeDirect
Biological processPlant defense0.00003775InformativeDirect
Biological processNeurogenesis0.00007294InformativeDirect
Biological processSpermatogenesis0.0000003656Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentEndoplasmic reticulum0.00000153Moderately InformativeDirect
Cellular componentCytoskeleton0.000278Moderately InformativeDirect
Cellular componentMicrotubule0.0001628InformativeDirect
DomainTransit peptide0.0008124Moderately InformativeDirect
DomainTPR repeat0.0000000000006418Highly InformativeDirect
Molecular functionZinc0Least InformativeDirect
Post-translational modificationChaperone0InformativeDirect
Post-translational modificationAcetylation0Least InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationMethylation0Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)lipid metabolism0Least InformativeDirect
UniPathway (UP)fatty acid metabolism0Moderately InformativeDirect
UniPathway (UP)lipid biosynthesis0Moderately InformativeDirect
UniPathway (UP)fatty acid biosynthesis0InformativeDirect
UniPathway (UP)prostaglandin biosynthesis0.00000963Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR008978 SSF49764 Protein matches
Abstract

Hsp20 is a mammalian small heat-shock protein family that occurs most abundantly in skeletal muscle and heart. It has a tendency to form dimers, via a disulphide linkage formed by an N-terminal cysteine, low heat stability and a poor chaperoning ability in comparison with other family members. Structurally, this and related proteins contain a beta-sandwich fold consisting of 8 strands in 2 beta-sheets in a greek-key topology [PubMed11702068].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 8 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a HSP20-like chaperones domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 8 hidden Markov models representing the HSP20-like chaperones superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]