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HSP20-like chaperones superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   HSP20-like chaperones [ 49763]
Superfamily:   HSP20-like chaperones [ 49764] (4)
Families:   HSP20 [ 49765]
  Co-chaperone p23-like [ 49768] (2)
  GS domain [ 101580] (2)
  Nuclear movement domain [ 117092] (2)


Superfamily statistics
Genomes (2,402) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 15,640 53,389 9
Proteins 15,337 52,742 9


Functional annotation
General category Processes_IC
Detailed category Protein modification

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus0.000000000084450.008261Least InformativeInherited
Biological Process (BP)response to abiotic stimulus00Moderately InformativeDirect
Biological Process (BP)response to organic substance0.81391Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.084820.5331Moderately InformativeInherited
Biological Process (BP)response to temperature stimulus00InformativeDirect
Biological Process (BP)response to radiation11InformativeInherited
Biological Process (BP)response to oxidative stress0.012360.006984InformativeInherited
Biological Process (BP)response to heat00Highly InformativeDirect
Biological Process (BP)protein folding0.000000000000014920Highly InformativeDirect
Biological Process (BP)response to hydrogen peroxide0.00000060270.00000000007181Highly InformativeDirect
Biological Process (BP)response to arsenic-containing substance0.000017910.00000001723Highly InformativeDirect
Molecular Function (MF)binding0.028170.08054Least InformativeInherited
Cellular Component (CC)non-membrane-bounded organelle0.1310.961Least InformativeInherited
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)supramolecular polymer0.000065040.000001953InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 0.1642 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.008261 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) response to abiotic stimulus 0 Moderately Informative Direct
Biological Process (BP) cellular component assembly 0.000008838 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 0.0001116 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.1002 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.858 Moderately Informative Inherited
Biological Process (BP) nitrogen compound transport 0.4876 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.7984 Moderately Informative Inherited
Biological Process (BP) single-organism transport 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.9366 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 0.1144 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.5576 Moderately Informative Inherited
Biological Process (BP) protein complex biogenesis 0.02663 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.6045 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.6799 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.7801 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.05374 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.7082 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.5331 Moderately Informative Inherited
Biological Process (BP) response to temperature stimulus 0 Informative Direct
Biological Process (BP) organelle assembly 0.0008727 Informative Direct
Biological Process (BP) microtubule-based process 0.000000004838 Informative Direct
Biological Process (BP) monocarboxylic acid biosynthetic process 0.000008916 Informative Direct
Biological Process (BP) fatty acid metabolic process 0.0003071 Informative Direct
Biological Process (BP) intracellular transport 0.1418 Informative Inherited
Biological Process (BP) movement of cell or subcellular component 0.08614 Informative Inherited
Biological Process (BP) protein transport 0.07577 Informative Inherited
Biological Process (BP) regulation of system process 0.05683 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.2969 Informative Inherited
Biological Process (BP) regulation of catabolic process 0.003561 Informative Inherited
Biological Process (BP) regulation of proteolysis 0.004428 Informative Inherited
Biological Process (BP) regulation of cell cycle 0.1811 Informative Inherited
Biological Process (BP) cellular protein complex assembly 0.1007 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.08891 Informative Inherited
Biological Process (BP) response to radiation 1 Informative Inherited
Biological Process (BP) single-organism cellular localization 0.06407 Informative Inherited
Biological Process (BP) organelle localization 0.3025 Informative Inherited
Biological Process (BP) localization of cell 0.5139 Informative Inherited
Biological Process (BP) generation of neurons 0.8356 Informative Inherited
Biological Process (BP) locomotion 0.8657 Informative Inherited
Biological Process (BP) response to oxidative stress 0.006984 Informative Inherited
Biological Process (BP) response to heat 0 Highly Informative Direct
Biological Process (BP) protein folding 0 Highly Informative Direct
Biological Process (BP) response to hydrogen peroxide 0.00000000007181 Highly Informative Direct
Biological Process (BP) response to arsenic-containing substance 0.00000001723 Highly Informative Direct
Biological Process (BP) microtubule-based movement 0.0000000002408 Highly Informative Direct
Biological Process (BP) regulation of protein stability 0.00000006419 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.000004692 Highly Informative Direct
Biological Process (BP) regulation of microtubule-based process 0.00002182 Highly Informative Direct
Biological Process (BP) regulation of protein catabolic process 0.00008055 Highly Informative Direct
Biological Process (BP) plasma membrane bounded cell projection organization 0.4305 Highly Informative Inherited
Biological Process (BP) cell projection assembly 0.001129 Highly Informative Inherited
Biological Process (BP) microtubule cytoskeleton organization 0.2168 Highly Informative Inherited
Biological Process (BP) establishment of organelle localization 0.1528 Highly Informative Inherited
Molecular Function (MF) binding 0.08054 Least Informative Inherited
Molecular Function (MF) lyase activity 0.3517 Moderately Informative Inherited
Molecular Function (MF) structural molecule activity 0.357 Moderately Informative Inherited
Molecular Function (MF) identical protein binding 0.0000002371 Informative Direct
Molecular Function (MF) protein dimerization activity 0.0009565 Informative Direct
Molecular Function (MF) receptor binding 0.8636 Informative Inherited
Molecular Function (MF) hydro-lyase activity 0.002631 Informative Inherited
Molecular Function (MF) chaperone binding 0.000009147 Highly Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0.961 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.01579 Least Informative Inherited
Cellular Component (CC) supramolecular polymer 0.000001953 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0.00119Least InformativeInherited
Enzyme Commission (EC)Acting on NADH or NADPH0.00000000003112Moderately InformativeDirect
Enzyme Commission (EC)With a heme protein as acceptor0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processUbl conjugation pathway0.0000004277Moderately InformativeDirect
Biological processDifferentiation0.02344Moderately InformativeInherited
Biological processCell cycle0.515Moderately InformativeInherited
Biological processStress response0InformativeDirect
Biological processMitosis0.00003747InformativeDirect
Biological processPlant defense0.00005747InformativeDirect
Biological processNeurogenesis0.00007752InformativeDirect
Biological processSpermatogenesis0.0000003752Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentEndoplasmic reticulum0.000001524Moderately InformativeDirect
Cellular componentCytoskeleton0.0003011Moderately InformativeDirect
Cellular componentMicrotubule0.0001632InformativeDirect
DomainTransit peptide0.0008564Moderately InformativeDirect
DomainTPR repeat0.0000000000006785Highly InformativeDirect
Molecular functionZinc0Least InformativeDirect
Post-translational modificationChaperone0InformativeDirect
Post-translational modificationAcetylation0Least InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationMethylation0Moderately InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR008978 SSF49764 Protein matches
Abstract

Hsp20 is a mammalian small heat-shock protein family that occurs most abundantly in skeletal muscle and heart. It has a tendency to form dimers, via a disulphide linkage formed by an N-terminal cysteine, low heat stability and a poor chaperoning ability in comparison with other family members. Structurally, this and related proteins contain a beta-sandwich fold consisting of 8 strands in 2 beta-sheets in a greek-key topology [PubMed11702068].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 8 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a HSP20-like chaperones domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 8 hidden Markov models representing the HSP20-like chaperones superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]