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Galactose-binding domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Galactose-binding domain-like [ 49784]
Superfamily:   Galactose-binding domain-like [ 49785] (32)
Families:   Galactose-binding domain [ 49786] (2)
  Discoidin domain (FA58C, coagulation factor 5/8 C-terminal domain) [ 49791] (3)
  APC10-like [ 69210] (2)
  delta-Endotoxin, C-terminal domain [ 49796]
  Ephrin receptor ligand binding domain [ 49800] (2)
  beta-Galactosidase/glucuronidase, N-terminal domain [ 49803] (4)
  Chondroitin ABC lyase I, N-terminal domain [ 89236]
  CBM4/9 [ 74893] (3)
  Family 6 carbohydrate binding module, CBM6 [ 69213] (4)
  CBM15 [ 69216]
  Family 17 carbohydrate binding module, CBM17 [ 69219]
  CBM22 [ 49811]
  Family 27 carbohydrate binding module, CBM27 [ 89241] (2)
  Family 29 carbohydrate binding module, CBM29 [ 89244]
  Fucose binding lectin [ 74896]
  N-terminal domain of xrcc1 [ 49814]
  F-box associated region, FBA [ 101585]
  Allantoicase repeat [ 101588]
  PepX C-terminal domain-like [ 69222] (3)
  PA-IL, galactose-binding lectin 1 [ 82022]
  Proprotein convertase P-domain [ 89249] (3)
  Family 28 carbohydrate binding module, CBM28 [ 110122]
  Family 30 carbohydrate binding module, CBM30 (PKD repeat) [ 110125]
  Rhamnogalacturonase B, RhgB, C-terminal domain [ 110128]
  Hypothetical protein AT3g04780/F7O18 27 [ 117108]
  Beta-galactosidase LacA, domains 4 and 5 [ 117111]
  Family 36 carbohydrate binding module, CBM36 [ 117114]
  Extended PAW domain [ 141113]
  CBM11 [ 141116]
  beta-mannanase CBM [ 141119]
  YxiM N-terminal domain-like [ 158963]
  NPCBM-like [ 158966] (2)


Superfamily statistics
Genomes (2,327) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 37,571 174,647 111
Proteins 31,214 148,065 104


Functional annotation
General category Metabolism
Detailed category Carbohydrate metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biological regulation0.015160.000000007467Least InformativeInherited
Biological Process (BP)macromolecule metabolic process0.30850.000000000000003734Least InformativeInherited
Biological Process (BP)organonitrogen compound metabolic process0.74320.0000000000001015Least InformativeInherited
Biological Process (BP)primary metabolic process0.93860.0000002092Least InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.0005480.02076Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.35141Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.067150.01952Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.63550.0008097Moderately InformativeInherited
Biological Process (BP)regulation of response to stimulus0.013310.2434Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.11650.002325Moderately InformativeInherited
Biological Process (BP)cellular macromolecule catabolic process0.00025440.00001252InformativeDirect
Biological Process (BP)proteolysis0.00080280.0001206InformativeDirect
Biological Process (BP)regulation of defense response0.00000002261InformativeInherited
Biological Process (BP)regulation of response to external stimulus0.000000034370.06536InformativeInherited
Biological Process (BP)regulation of immune response0.000000020641InformativeInherited
Biological Process (BP)regulation of proteolysis0.00023210.001648InformativeInherited
Biological Process (BP)regulation of humoral immune response0.00000000000020540.00003733Highly InformativeDirect
Biological Process (BP)regulation of acute inflammatory response0.00000000000032020.00001669Highly InformativeDirect
Biological Process (BP)protein modification by small protein conjugation0.0017040.00002791Highly InformativeInherited
Biological Process (BP)modification-dependent macromolecule catabolic process0.000013560.9413Highly InformativeInherited
Biological Process (BP)cellular protein catabolic process0.000043310.2314Highly InformativeInherited
Biological Process (BP)regulation of protein processing0.000091750.006459Highly InformativeInherited
Molecular Function (MF)binding0.19240.8259Least InformativeInherited
Molecular Function (MF)small molecule binding0.000082851Moderately InformativeInherited
Molecular Function (MF)monosaccharide binding0.0000000000000027270.0000003859Highly InformativeDirect
Cellular Component (CC)intracellular organelle part0.061271Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.40381Least InformativeInherited
Cellular Component (CC)transferase complex0.000043530.00007232Moderately InformativeDirect
Cellular Component (CC)extracellular region part0.00039170.00000000002675Moderately InformativeDirect
Cellular Component (CC)nuclear part0.0013131Moderately InformativeInherited
Cellular Component (CC)ubiquitin ligase complex0.000000014810.00000000000004722InformativeDirect
Cellular Component (CC)nuclear ubiquitin ligase complex0.0000000030350.00007836Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biological regulation 0.000000007467 Least Informative Direct
Biological Process (BP) macromolecule metabolic process 0.000000000000003734 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.000001349 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0.0000000000001015 Least Informative Direct
Biological Process (BP) primary metabolic process 0.0000002092 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0.0000009897 Least Informative Direct
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.1785 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular protein modification process 0.0008097 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0 Moderately Informative Direct
Biological Process (BP) cell differentiation 0 Moderately Informative Direct
Biological Process (BP) single organism signaling 0.000000008031 Moderately Informative Direct
Biological Process (BP) response to external stimulus 0.0000005459 Moderately Informative Direct
Biological Process (BP) cell communication 0.00000627 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.0002016 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.0002674 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.0004361 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.7748 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.02076 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.2133 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.2434 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.01952 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.001082 Moderately Informative Inherited
Biological Process (BP) immune system process 0.6537 Moderately Informative Inherited
Biological Process (BP) defense response 0.8706 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.1015 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.1407 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) peptide metabolic process 0.4965 Moderately Informative Inherited
Biological Process (BP) animal organ development 0.8402 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.007862 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.002325 Moderately Informative Inherited
Biological Process (BP) tissue development 0.7658 Moderately Informative Inherited
Biological Process (BP) reproduction 0.2862 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.8893 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.004451 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 0.00001252 Informative Direct
Biological Process (BP) proteolysis 0.0001206 Informative Direct
Biological Process (BP) cell surface receptor signaling pathway 0 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) phosphorylation 0 Informative Direct
Biological Process (BP) localization of cell 0 Informative Direct
Biological Process (BP) cellular component morphogenesis 0 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.00000000000007621 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.0000000001336 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 0.0000000003105 Informative Direct
Biological Process (BP) regulation of nervous system development 0.0000000004311 Informative Direct
Biological Process (BP) central nervous system development 0.000000002277 Informative Direct
Biological Process (BP) circulatory system development 0.0000001917 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.0000003621 Informative Direct
Biological Process (BP) response to wounding 0.0000004108 Informative Direct
Biological Process (BP) regulation of hydrolase activity 0.0000008777 Informative Direct
Biological Process (BP) cell development 0.000001087 Informative Direct
Biological Process (BP) pigment metabolic process 0.000003395 Informative Direct
Biological Process (BP) regulation of cell differentiation 0.0000369 Informative Direct
Biological Process (BP) regulation of growth 0.00003947 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0.0000719 Informative Direct
Biological Process (BP) positive regulation of developmental process 0.0002042 Informative Direct
Biological Process (BP) secondary metabolic process 0.0006632 Informative Direct
Biological Process (BP) positive regulation of catalytic activity 0.7139 Informative Inherited
Biological Process (BP) regulation of protein localization 0.6333 Informative Inherited
Biological Process (BP) regulation of cellular localization 0.5313 Informative Inherited
Biological Process (BP) generation of neurons 0.004596 Informative Inherited
Biological Process (BP) regulation of protein modification process 0.02332 Informative Inherited
Biological Process (BP) regulation of phosphorylation 0.04966 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 1 Informative Inherited
Biological Process (BP) regulation of proteolysis 0.001648 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.01403 Informative Inherited
Biological Process (BP) system process 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.6218 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.001197 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.04336 Informative Inherited
Biological Process (BP) embryo development 1 Informative Inherited
Biological Process (BP) immune response 0.3727 Informative Inherited
Biological Process (BP) regulation of locomotion 0.001368 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.02569 Informative Inherited
Biological Process (BP) immune effector process 0.01506 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.006915 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.00134 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.01107 Informative Inherited
Biological Process (BP) response to temperature stimulus 0.1228 Informative Inherited
Biological Process (BP) animal organ morphogenesis 1 Informative Inherited
Biological Process (BP) regulation of defense response 1 Informative Inherited
Biological Process (BP) response to radiation 1 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.06536 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) multi-organism reproductive process 0.7533 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) multicellular organism reproduction 1 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) carbohydrate catabolic process 0.001403 Informative Inherited
Biological Process (BP) polysaccharide metabolic process 0.07688 Informative Inherited
Biological Process (BP) regulation of humoral immune response 0.00003733 Highly Informative Direct
Biological Process (BP) regulation of acute inflammatory response 0.00001669 Highly Informative Direct
Biological Process (BP) protein modification by small protein conjugation 0.00002791 Highly Informative Direct
Biological Process (BP) positive regulation of cellular component biogenesis 0 Highly Informative Direct
Biological Process (BP) vasculogenesis 0 Highly Informative Direct
Biological Process (BP) plasma membrane bounded cell projection organization 0 Highly Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 0 Highly Informative Direct
Biological Process (BP) protein maturation 0 Highly Informative Direct
Biological Process (BP) neuron development 0.00000000000003101 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.0000000000001294 Highly Informative Direct
Biological Process (BP) regulation of cell size 0.000000000001103 Highly Informative Direct
Biological Process (BP) biological adhesion 0.000000000001161 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 0.000000000006239 Highly Informative Direct
Biological Process (BP) angiogenesis 0.000000001087 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.000000009242 Highly Informative Direct
Biological Process (BP) regulation of GTPase activity 0.00000002023 Highly Informative Direct
Biological Process (BP) forebrain development 0.00000003011 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 0.00000004868 Highly Informative Direct
Biological Process (BP) positive regulation of nervous system development 0.0000008247 Highly Informative Direct
Biological Process (BP) coagulation 0.000004933 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 0.000008442 Highly Informative Direct
Biological Process (BP) glycoprotein metabolic process 0.00007097 Highly Informative Direct
Biological Process (BP) regulation of response to wounding 0.0002291 Highly Informative Direct
Biological Process (BP) negative regulation of growth 0.000263 Highly Informative Direct
Biological Process (BP) polysaccharide catabolic process 0.0005502 Highly Informative Direct
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.0006305 Highly Informative Direct
Biological Process (BP) innate immune response 0.0008516 Highly Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0.1462 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular protein localization 0.2869 Highly Informative Inherited
Biological Process (BP) regulation of binding 0.001841 Highly Informative Inherited
Biological Process (BP) hemostasis 0.003785 Highly Informative Inherited
Biological Process (BP) wound healing 0.003788 Highly Informative Inherited
Biological Process (BP) negative regulation of nervous system development 0.01291 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.005454 Highly Informative Inherited
Biological Process (BP) positive regulation of supramolecular fiber organization 0.03447 Highly Informative Inherited
Biological Process (BP) nervous system process 0.02885 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.07941 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 0.0133 Highly Informative Inherited
Biological Process (BP) small GTPase mediated signal transduction 0.1071 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 1 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.01306 Highly Informative Inherited
Biological Process (BP) regulation of cell growth 0.001628 Highly Informative Inherited
Biological Process (BP) negative regulation of cell development 0.02571 Highly Informative Inherited
Biological Process (BP) regulation of epithelial cell migration 0.1258 Highly Informative Inherited
Biological Process (BP) cell projection assembly 0.8583 Highly Informative Inherited
Biological Process (BP) modification-dependent macromolecule catabolic process 0.9413 Highly Informative Inherited
Biological Process (BP) cellular protein catabolic process 0.2314 Highly Informative Inherited
Biological Process (BP) glycosaminoglycan metabolic process 0.04266 Highly Informative Inherited
Biological Process (BP) aminoglycan catabolic process 0.07467 Highly Informative Inherited
Biological Process (BP) embryonic organ development 0.2682 Highly Informative Inherited
Biological Process (BP) tube morphogenesis 0.4449 Highly Informative Inherited
Biological Process (BP) heart development 0.1801 Highly Informative Inherited
Biological Process (BP) regulation of protein processing 0.006459 Highly Informative Inherited
Biological Process (BP) anatomical structure maturation 0.003478 Highly Informative Inherited
Biological Process (BP) cell maturation 0.06019 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.8664 Highly Informative Inherited
Biological Process (BP) germ cell development 1 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0.000004227 Least Informative Direct
Molecular Function (MF) binding 0.8259 Least Informative Inherited
Molecular Function (MF) transferase activity 0.001462 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.000000000001389 Moderately Informative Direct
Molecular Function (MF) small molecule binding 1 Moderately Informative Inherited
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) signal transducer activity 0 Informative Direct
Molecular Function (MF) hydrolase activity, acting on glycosyl bonds 0 Informative Direct
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.000000000005781 Informative Direct
Molecular Function (MF) macromolecular complex binding 0.004253 Informative Inherited
Molecular Function (MF) peptidase activity, acting on L-amino acid peptides 0.1806 Informative Inherited
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 0.5979 Informative Inherited
Molecular Function (MF) monosaccharide binding 0.0000003859 Highly Informative Direct
Molecular Function (MF) transmembrane signaling receptor activity 0 Highly Informative Direct
Molecular Function (MF) serine hydrolase activity 0 Highly Informative Direct
Molecular Function (MF) hydrolase activity, hydrolyzing O-glycosyl compounds 0 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0.00008483 Highly Informative Direct
Molecular Function (MF) ubiquitin-like protein transferase activity 0.008211 Highly Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) membrane 0.03045 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) transferase complex 0.00007232 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.00000000002675 Moderately Informative Direct
Cellular Component (CC) intrinsic component of membrane 0.0000003098 Moderately Informative Direct
Cellular Component (CC) vesicle 0.000004426 Moderately Informative Direct
Cellular Component (CC) cell projection 0.000007062 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.0000372 Moderately Informative Direct
Cellular Component (CC) endomembrane system 0.0003832 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) bounding membrane of organelle 0.01084 Moderately Informative Inherited
Cellular Component (CC) whole membrane 0.3722 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) ubiquitin ligase complex 0.00000000000004722 Informative Direct
Cellular Component (CC) cytoplasmic vesicle part 0.0000009233 Informative Direct
Cellular Component (CC) external encapsulating structure 0.00008 Informative Direct
Cellular Component (CC) secretory granule 0.0002763 Informative Direct
Cellular Component (CC) transporter complex 0.255 Informative Inherited
Cellular Component (CC) endosome 0.01097 Informative Inherited
Cellular Component (CC) nuclear ubiquitin ligase complex 0.00007836 Highly Informative Direct
Cellular Component (CC) intrinsic component of plasma membrane 0.0000007079 Highly Informative Direct
Cellular Component (CC) plant-type cell wall 0.000001226 Highly Informative Direct
Cellular Component (CC) endosome membrane 0.00002613 Highly Informative Direct
Cellular Component (CC) cytoplasmic vesicle lumen 0.00004156 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0.0161Least InformativeInherited
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl0Moderately InformativeDirect
Enzyme Commission (EC)In linear amides1Moderately InformativeInherited
Enzyme Commission (EC)Serine endopeptidases0.734Moderately InformativeInherited
Enzyme Commission (EC)Dipeptidyl-peptidases and tripeptidyl-peptidases0InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Beta-galactosidase0InformativeDirect
Enzyme Commission (EC)Acting on polysaccharides0.000000000000003708InformativeDirect
Enzyme Commission (EC)In linear amidines0Highly InformativeDirect
Enzyme Commission (EC)Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagin0Highly InformativeDirect
Enzyme Commission (EC)Furin4.713e-16Highly InformativeDirect
Enzyme Commission (EC)Rhamnogalacturonan endolyase0.000000000000005085Highly InformativeDirect
Enzyme Commission (EC)Proprotein convertase 20.000000000001228Highly InformativeDirect
Enzyme Commission (EC)Proprotein convertase 10.00000000005325Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processUbl conjugation pathway0Moderately InformativeDirect
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processAngiogenesis0InformativeDirect
Biological processSporulation0InformativeDirect
Biological processNeurogenesis0InformativeDirect
Biological processCell adhesion0InformativeDirect
Biological processPolysaccharide degradation0InformativeDirect
Biological processHemostasis0.0000000005668InformativeDirect
Biological processPurine metabolism0Highly InformativeDirect
Biological processBlood coagulation0.0000000005253Highly InformativeDirect
Biological processOsteogenesis0.0000007395Highly InformativeDirect
Biological processFertilization0.000001388Highly InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentEndosome0.0000002055Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.00002219Moderately InformativeDirect
Cellular componentCell junction0.0005953Moderately InformativeDirect
Cellular componentGolgi apparatus0.0009057Moderately InformativeDirect
Cellular componentLysosome0InformativeDirect
Cellular componentApoplast0Highly InformativeDirect
DiseaseDisease mutation0.0005063Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainRepeat0.00001186Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainEGF-like domain0InformativeDirect
DomainLaminin EGF-like domain0.000000001688Highly InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionSodium0InformativeDirect
Molecular functionLectin0.0000000008522InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0.0000000001281Moderately InformativeDirect
Post-translational modificationProtease0.0000007027Moderately InformativeDirect
Post-translational modificationKinase0.002167Moderately InformativeInherited
Post-translational modificationSerine protease0InformativeDirect
Post-translational modificationGlycosidase0InformativeDirect
Post-translational modificationToxin0InformativeDirect
Post-translational modificationHeparin-binding0.00000004013InformativeDirect
Post-translational modificationTyrosine-protein kinase0Highly InformativeDirect
Post-translational modificationAminopeptidase0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0.00000001898Least InformativeDirect
Post-translational modificationCleavage on pair of basic residues0.00000000000004605Moderately InformativeDirect
Post-translational modificationZymogen0InformativeDirect
Post-translational modificationSulfation0.00004367InformativeDirect
Post-translational modificationProteoglycan0.08116InformativeInherited
Post-translational modificationHeparan sulfate0.0000000000002103Highly InformativeDirect
Post-translational modificationPeptidoglycan-anchor0.0002275Highly InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR008979 SSF49785 Protein matches
Abstract

Proteins containing a galactose-binding domain-like fold can be found in several different protein families, in both eukaryotes and prokaryotes. The common function of these domains is to bind to specific ligands, such as cell-surface-attached carbohydrate substrates for galactose oxidase and sialidase [PubMed2002850], phospholipids on the outer side of the mammalian cell membrane for coagulation factor Va [PubMed10586886], membrane-anchored ephrin for the Eph family of receptor tyrosine kinases [PubMed11780069], and a complex of broken single-stranded DNA and DNA polymerase beta for XRCC1 [PubMed10467102].

The structure of the galactose-binding domain-like members consists of a beta-sandwich, in which the strands making up the sheets exhibit a jellyroll fold. There is a high degree of similarity in the beta-sandwich and in the loops between different family members, despite an often low level of sequence similarity.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 65 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Galactose-binding domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 65 hidden Markov models representing the Galactose-binding domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]