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Galactose-binding domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Galactose-binding domain-like [ 49784]
Superfamily:   Galactose-binding domain-like [ 49785] (32)
Families:   Galactose-binding domain [ 49786] (2)
  Discoidin domain (FA58C, coagulation factor 5/8 C-terminal domain) [ 49791] (3)
  APC10-like [ 69210] (2)
  delta-Endotoxin, C-terminal domain [ 49796]
  Ephrin receptor ligand binding domain [ 49800] (2)
  beta-Galactosidase/glucuronidase, N-terminal domain [ 49803] (4)
  Chondroitin ABC lyase I, N-terminal domain [ 89236]
  CBM4/9 [ 74893] (3)
  Family 6 carbohydrate binding module, CBM6 [ 69213] (4)
  CBM15 [ 69216]
  Family 17 carbohydrate binding module, CBM17 [ 69219]
  CBM22 [ 49811]
  Family 27 carbohydrate binding module, CBM27 [ 89241] (2)
  Family 29 carbohydrate binding module, CBM29 [ 89244]
  Fucose binding lectin [ 74896]
  N-terminal domain of xrcc1 [ 49814]
  F-box associated region, FBA [ 101585]
  Allantoicase repeat [ 101588]
  PepX C-terminal domain-like [ 69222] (3)
  PA-IL, galactose-binding lectin 1 [ 82022]
  Proprotein convertase P-domain [ 89249] (3)
  Family 28 carbohydrate binding module, CBM28 [ 110122]
  Family 30 carbohydrate binding module, CBM30 (PKD repeat) [ 110125]
  Rhamnogalacturonase B, RhgB, C-terminal domain [ 110128]
  Hypothetical protein AT3g04780/F7O18 27 [ 117108]
  Beta-galactosidase LacA, domains 4 and 5 [ 117111]
  Family 36 carbohydrate binding module, CBM36 [ 117114]
  Extended PAW domain [ 141113]
  CBM11 [ 141116]
  beta-mannanase CBM [ 141119]
  YxiM N-terminal domain-like [ 158963]
  NPCBM-like [ 158966] (2)


Superfamily statistics
Genomes (2,325) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 37,327 174,647 111
Proteins 31,007 148,065 104


Functional annotation
General category Metabolism
Detailed category Carbohydrate metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biological regulation0.015620.0000001307Least InformativeInherited
Biological Process (BP)primary metabolic process0.93780.000000328Least InformativeInherited
Biological Process (BP)organonitrogen compound metabolic process0.73670.0000000000003118Least InformativeInherited
Biological Process (BP)macromolecule metabolic process0.29940.000000000000007367Least InformativeInherited
Biological Process (BP)regulation of gene expression0.34741Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.62370.0007164Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.1820.03169Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.27290.002951Moderately InformativeInherited
Biological Process (BP)regulation of response to stimulus0.014120.3848Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.00062040.03295Moderately InformativeInherited
Biological Process (BP)regulation of proteolysis0.0002130.001708InformativeInherited
Biological Process (BP)proteolysis0.011840.0007076InformativeInherited
Biological Process (BP)cellular macromolecule catabolic process0.002560.00003141InformativeInherited
Biological Process (BP)regulation of response to external stimulus0.000000030630.04951InformativeInherited
Biological Process (BP)regulation of defense response0.000000020751InformativeInherited
Biological Process (BP)regulation of acute inflammatory response0.00000000000027620.00001022Highly InformativeDirect
Biological Process (BP)regulation of humoral immune response0.00000000000022120.00002584Highly InformativeDirect
Biological Process (BP)protein modification by small protein conjugation0.0015830.00001501Highly InformativeInherited
Biological Process (BP)modification-dependent macromolecule catabolic process0.00025120.9955Highly InformativeInherited
Biological Process (BP)proteolysis involved in cellular protein catabolic process0.00047081Highly InformativeInherited
Biological Process (BP)regulation of protein processing0.000074460.0039Highly InformativeInherited
Molecular Function (MF)binding0.18210.89Least InformativeInherited
Molecular Function (MF)small molecule binding0.000058361Moderately InformativeInherited
Molecular Function (MF)monosaccharide binding0.000000000000002070.0000003698Highly InformativeDirect
Cellular Component (CC)macromolecular complex0.071771Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.40881Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.058121Least InformativeInherited
Cellular Component (CC)extracellular region part0.00032920.000000000288Moderately InformativeDirect
Cellular Component (CC)transferase complex0.000044740.00004404Moderately InformativeDirect
Cellular Component (CC)nuclear part0.0011951Moderately InformativeInherited
Cellular Component (CC)ubiquitin ligase complex0.000000015650.00000000000002355InformativeDirect
Cellular Component (CC)nuclear ubiquitin ligase complex0.00000000360.00006791Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) macromolecule metabolic process 0.000000000000007367 Least Informative Direct
Biological Process (BP) primary metabolic process 0.000000328 Least Informative Direct
Biological Process (BP) response to stimulus 0.00005364 Least Informative Direct
Biological Process (BP) biological regulation 0.0000001307 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.000002379 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0.0000000000003118 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.2287 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular protein modification process 0.0007164 Moderately Informative Direct
Biological Process (BP) cell communication 0.000003693 Moderately Informative Direct
Biological Process (BP) response to external stimulus 0.000007773 Moderately Informative Direct
Biological Process (BP) single organism signaling 0.000000002797 Moderately Informative Direct
Biological Process (BP) cellular developmental process 0.00000000000002124 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.0002822 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 0.0007323 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.1675 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.002444 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.3848 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.03169 Moderately Informative Inherited
Biological Process (BP) immune system process 0.4971 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.1221 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.003029 Moderately Informative Inherited
Biological Process (BP) peptide metabolic process 0.4593 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.00713 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.002951 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.1704 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.03295 Moderately Informative Inherited
Biological Process (BP) system development 0.003718 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.003726 Moderately Informative Inherited
Biological Process (BP) proteolysis 0.0007076 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0 Informative Direct
Biological Process (BP) cell surface receptor signaling pathway 0 Informative Direct
Biological Process (BP) central nervous system development 0.00000005662 Informative Direct
Biological Process (BP) phosphorylation 0 Informative Direct
Biological Process (BP) secondary metabolic process 0.0005256 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.000005065 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.00000000000001439 Informative Direct
Biological Process (BP) regulation of growth 0.0002159 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) pigment metabolic process 0.000002291 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.00000000008233 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0.00003141 Informative Direct
Biological Process (BP) regulation of cell differentiation 0.0000478 Informative Direct
Biological Process (BP) cell development 0.000002828 Informative Direct
Biological Process (BP) positive regulation of developmental process 0.0002655 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.0000000001424 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0.00007078 Informative Direct
Biological Process (BP) regulation of hydrolase activity 0.00000008997 Informative Direct
Biological Process (BP) regulation of nervous system development 0.000000001962 Informative Direct
Biological Process (BP) circulatory system development 0.000004627 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 0.0000000002604 Informative Direct
Biological Process (BP) positive regulation of catalytic activity 0.5822 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.8579 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.003968 Informative Inherited
Biological Process (BP) regulation of protein modification process 0.05192 Informative Inherited
Biological Process (BP) regulation of phosphorylation 0.1095 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 1 Informative Inherited
Biological Process (BP) animal organ morphogenesis 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 1 Informative Inherited
Biological Process (BP) system process 1 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.03473 Informative Inherited
Biological Process (BP) regulation of locomotion 0.00242 Informative Inherited
Biological Process (BP) immune effector process 0.009248 Informative Inherited
Biological Process (BP) immune response 0.2177 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) regulation of proteolysis 0.001708 Informative Inherited
Biological Process (BP) generation of neurons 0.04048 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.001353 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.002114 Informative Inherited
Biological Process (BP) response to temperature stimulus 0.1278 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.01859 Informative Inherited
Biological Process (BP) embryo development 1 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.04951 Informative Inherited
Biological Process (BP) regulation of defense response 1 Informative Inherited
Biological Process (BP) tissue development 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.2848 Informative Inherited
Biological Process (BP) polysaccharide metabolic process 0.06751 Informative Inherited
Biological Process (BP) carbohydrate catabolic process 0.001155 Informative Inherited
Biological Process (BP) polysaccharide catabolic process 0.00052 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 0.0000000004924 Highly Informative Direct
Biological Process (BP) angiogenesis 0.00000001666 Highly Informative Direct
Biological Process (BP) regulation of acute inflammatory response 0.00001022 Highly Informative Direct
Biological Process (BP) regulation of humoral immune response 0.00002584 Highly Informative Direct
Biological Process (BP) chemotaxis 0 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.000000000004184 Highly Informative Direct
Biological Process (BP) brain development 0.00000001124 Highly Informative Direct
Biological Process (BP) regulation of cell size 0.0000000003306 Highly Informative Direct
Biological Process (BP) glycoprotein metabolic process 0.00002691 Highly Informative Direct
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.0003401 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.000000000003115 Highly Informative Direct
Biological Process (BP) regulation of neuron projection development 0.0006657 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 0.00000003647 Highly Informative Direct
Biological Process (BP) biological adhesion 0.00000000000117 Highly Informative Direct
Biological Process (BP) protein modification by small protein conjugation 0.00001501 Highly Informative Direct
Biological Process (BP) regulation of GTPase activity 0.00000001745 Highly Informative Direct
Biological Process (BP) positive regulation of cellular component biogenesis 0.0000000000001529 Highly Informative Direct
Biological Process (BP) innate immune response 0.0005209 Highly Informative Direct
Biological Process (BP) negative regulation of growth 0.0004171 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 0.0001536 Highly Informative Direct
Biological Process (BP) neuron development 0.0000000000007376 Highly Informative Direct
Biological Process (BP) protein maturation 0 Highly Informative Direct
Biological Process (BP) positive regulation of nervous system development 0.00000004573 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.00000004358 Highly Informative Direct
Biological Process (BP) plasma membrane bounded cell projection organization 0 Highly Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0.1467 Highly Informative Inherited
Biological Process (BP) regulation of binding 0.001127 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.1206 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.001696 Highly Informative Inherited
Biological Process (BP) tube morphogenesis 0.507 Highly Informative Inherited
Biological Process (BP) neurological system process 0.1344 Highly Informative Inherited
Biological Process (BP) negative regulation of nervous system development 0.01186 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 0.01918 Highly Informative Inherited
Biological Process (BP) small GTPase mediated signal transduction 0.09192 Highly Informative Inherited
Biological Process (BP) positive regulation of supramolecular fiber organization 0.0563 Highly Informative Inherited
Biological Process (BP) regulation of cell growth 0.006108 Highly Informative Inherited
Biological Process (BP) negative regulation of cell development 0.02057 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.9416 Highly Informative Inherited
Biological Process (BP) cell projection assembly 0.9208 Highly Informative Inherited
Biological Process (BP) modification-dependent macromolecule catabolic process 0.9955 Highly Informative Inherited
Biological Process (BP) proteolysis involved in cellular protein catabolic process 1 Highly Informative Inherited
Biological Process (BP) aminoglycan catabolic process 0.07061 Highly Informative Inherited
Biological Process (BP) glycosaminoglycan metabolic process 0.03671 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 0.01383 Highly Informative Inherited
Biological Process (BP) regulation of protein processing 0.0039 Highly Informative Inherited
Molecular Function (MF) transferase activity 0.0009291 Least Informative Direct
Molecular Function (MF) hydrolase activity 0.000008488 Least Informative Direct
Molecular Function (MF) binding 0.89 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.000000000001338 Moderately Informative Direct
Molecular Function (MF) small molecule binding 1 Moderately Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 0.1518 Moderately Informative Inherited
Molecular Function (MF) signal transducer activity 0 Informative Direct
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.000000000006852 Informative Direct
Molecular Function (MF) hydrolase activity, acting on glycosyl bonds 0 Informative Direct
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) macromolecular complex binding 0.04063 Informative Inherited
Molecular Function (MF) peptidase activity, acting on L-amino acid peptides 0.2258 Informative Inherited
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 0.5819 Informative Inherited
Molecular Function (MF) hydrolase activity, hydrolyzing O-glycosyl compounds 0 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0 Highly Informative Direct
Molecular Function (MF) transmembrane signaling receptor activity 0 Highly Informative Direct
Molecular Function (MF) serine hydrolase activity 0.00000000000001173 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0.00002367 Highly Informative Direct
Molecular Function (MF) monosaccharide binding 0.0000003698 Highly Informative Direct
Molecular Function (MF) ubiquitin-like protein transferase activity 0.008377 Highly Informative Inherited
Cellular Component (CC) membrane 0.01509 Least Informative Inherited
Cellular Component (CC) macromolecular complex 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) plasma membrane 0.000004965 Moderately Informative Direct
Cellular Component (CC) intrinsic component of membrane 0.0000001463 Moderately Informative Direct
Cellular Component (CC) vesicle 0.000001502 Moderately Informative Direct
Cellular Component (CC) cell projection 0.0000003705 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.000000000288 Moderately Informative Direct
Cellular Component (CC) transferase complex 0.00004404 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) bounding membrane of organelle 0.01092 Moderately Informative Inherited
Cellular Component (CC) whole membrane 0.3909 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.07509 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) ubiquitin ligase complex 0.00000000000002355 Informative Direct
Cellular Component (CC) cell surface 0.0007099 Informative Direct
Cellular Component (CC) secretory granule 0.0001875 Informative Direct
Cellular Component (CC) external encapsulating structure 0.00005244 Informative Direct
Cellular Component (CC) neuron projection 0.0006542 Informative Direct
Cellular Component (CC) cytoplasmic vesicle part 0.0000003943 Informative Direct
Cellular Component (CC) transporter complex 0.2108 Informative Inherited
Cellular Component (CC) endosome 0.007775 Informative Inherited
Cellular Component (CC) nuclear ubiquitin ligase complex 0.00006791 Highly Informative Direct
Cellular Component (CC) plant-type cell wall 0.000001459 Highly Informative Direct
Cellular Component (CC) endosome membrane 0.00002435 Highly Informative Direct
Cellular Component (CC) intrinsic component of plasma membrane 0.0000003623 Highly Informative Direct
Cellular Component (CC) cytoplasmic vesicle lumen 0.00003111 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0.0161Least InformativeInherited
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl0Moderately InformativeDirect
Enzyme Commission (EC)In linear amides1Moderately InformativeInherited
Enzyme Commission (EC)Serine endopeptidases0.734Moderately InformativeInherited
Enzyme Commission (EC)Dipeptidyl-peptidases and tripeptidyl-peptidases0InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Beta-galactosidase0InformativeDirect
Enzyme Commission (EC)Acting on polysaccharides0.000000000000003708InformativeDirect
Enzyme Commission (EC)In linear amidines0Highly InformativeDirect
Enzyme Commission (EC)Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagin0Highly InformativeDirect
Enzyme Commission (EC)Furin4.713e-16Highly InformativeDirect
Enzyme Commission (EC)Rhamnogalacturonan endolyase0.000000000000005085Highly InformativeDirect
Enzyme Commission (EC)Proprotein convertase 20.000000000001228Highly InformativeDirect
Enzyme Commission (EC)Proprotein convertase 10.00000000005325Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.364Least InformativeInherited
Disease Ontology (DO)endocrine gland cancer0.006382InformativeInherited
Disease Ontology (DO)pancreatic ductal adenocarcinoma0.00002771Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.3307Least InformativeInherited
Phenotypic Abnormality (PA)Aplasia/hypoplasia involving the skeleton0.2256Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vertebral column0.3431Moderately InformativeInherited
Phenotypic Abnormality (PA)Aplasia/hypoplasia affecting bones of the axial skeleton0.2763InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the odontoid process0.0001637Highly InformativeDirect
Phenotypic Abnormality (PA)Aplasia/Hypoplasia involving the vertebral column0.003007Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.00159Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body region phenotype0.07952Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.1081Least InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development0.141Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.291Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.4541Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell differentiation0.01323InformativeInherited
Mammalian Phenotype (MP)abnormal spinal cord morphology0.1285InformativeInherited
Mammalian Phenotype (MP)abnormal axon guidance0.000004218Highly InformativeDirect
Mammalian Phenotype (MP)abnormal body wall morphology0.00007657Highly InformativeDirect
Mammalian Phenotype (MP)abnormal brain white matter morphology0.0003186Highly InformativeDirect
Mammalian Phenotype (MP)abnormal spinal cord white matter morphology0.03267Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.005979Least InformativeInherited
Worm Phenotype (WP)protein protein interaction variant0.0000006278Moderately InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)head0.6468Least InformativeInherited
Xenopus ANatomical entity (XAN)nervous system0.7683Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo1Least InformativeInherited
Xenopus ANatomical entity (XAN)brain0.9223Moderately InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.9333Moderately InformativeInherited
Xenopus ANatomical entity (XAN)hindbrain0.1712InformativeInherited
Xenopus ANatomical entity (XAN)vegetal hemisphere0.0007949Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)leaf0.724Least InformativeInherited
Plant ANatomical entity (PAN)fruit0.00000005513InformativeDirect
Plant ANatomical entity (PAN)rosette leaf0.00004888InformativeDirect
Plant ANatomical entity (PAN)juvenile vascular leaf0Highly InformativeDirect
Plant ANatomical entity (PAN)adult vascular leaf0Highly InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorus-containing groups1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Glycosylases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0.00759Moderately InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases0.3718Moderately InformativeInherited
Enzyme Commission (EC)Acyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds1Moderately InformativeInherited
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0.5101InformativeInherited
Enzyme Commission (EC)In linear amides1InformativeInherited
Enzyme Commission (EC)Receptor protein-tyrosine kinase0Highly InformativeDirect
Enzyme Commission (EC)Beta-galactosidase0Highly InformativeDirect
Enzyme Commission (EC)Dipeptidyl-peptidases and tripeptidyl-peptidases0Highly InformativeDirect
Enzyme Commission (EC)In linear amidines0Highly InformativeDirect
Enzyme Commission (EC)Acting on polysaccharides0Highly InformativeDirect
Enzyme Commission (EC)HECT-type E3 ubiquitin transferase0.00000004031Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processUbl conjugation pathway0Moderately InformativeDirect
Biological processAngiogenesis0InformativeDirect
Biological processCell adhesion0InformativeDirect
Biological processNeurogenesis0InformativeDirect
Biological processPolysaccharide degradation0InformativeDirect
Biological processSporulation0InformativeDirect
Biological processHemostasis0.0000000005623InformativeDirect
Biological processPurine metabolism0Highly InformativeDirect
Biological processBlood coagulation0.0000000005212Highly InformativeDirect
Biological processOsteogenesis0.0000007358Highly InformativeDirect
Biological processFertilization0.000001225Highly InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentEndosome0.0000001775Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.00001951Moderately InformativeDirect
Cellular componentGolgi apparatus0.0009238Moderately InformativeDirect
Cellular componentLysosome0InformativeDirect
Cellular componentApoplast0Highly InformativeDirect
DiseaseDisease mutation0.0004525Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainRepeat0.00001314Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainEGF-like domain0InformativeDirect
DomainLaminin EGF-like domain0.000000001686Highly InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionSodium0InformativeDirect
Molecular functionLectin0.0000000006803InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0.0000000001165Moderately InformativeDirect
Post-translational modificationProtease0.000001568Moderately InformativeDirect
Post-translational modificationKinase0.002051Moderately InformativeInherited
Post-translational modificationGlycosidase0InformativeDirect
Post-translational modificationSerine protease0InformativeDirect
Post-translational modificationToxin0InformativeDirect
Post-translational modificationHeparin-binding0.00000003004InformativeDirect
Post-translational modificationAminopeptidase0Highly InformativeDirect
Post-translational modificationTyrosine-protein kinase0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0.00000003398Least InformativeDirect
Post-translational modificationCleavage on pair of basic residues0.0000000000001192Moderately InformativeDirect
Post-translational modificationZymogen0InformativeDirect
Post-translational modificationSulfation0.00004332InformativeDirect
Post-translational modificationProteoglycan0.08194InformativeInherited
Post-translational modificationHeparan sulfate0.0000000000002066Highly InformativeDirect
Post-translational modificationPeptidoglycan-anchor0.0002294Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0.000004053Least InformativeDirect
UniPathway (UP)nitrogen metabolism0Moderately InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect
UniPathway (UP)glycan metabolism0Moderately InformativeDirect
UniPathway (UP)ureide metabolism0InformativeDirect
UniPathway (UP)glycan degradation0InformativeDirect
UniPathway (UP)N-glycan degradation0Highly InformativeDirect
UniPathway (UP)(S)-allantoin degradation0Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR008979 SSF49785 Protein matches
Abstract

Proteins containing a galactose-binding domain-like fold can be found in several different protein families, in both eukaryotes and prokaryotes. The common function of these domains is to bind to specific ligands, such as cell-surface-attached carbohydrate substrates for galactose oxidase and sialidase [PubMed2002850], phospholipids on the outer side of the mammalian cell membrane for coagulation factor Va [PubMed10586886], membrane-anchored ephrin for the Eph family of receptor tyrosine kinases [PubMed11780069], and a complex of broken single-stranded DNA and DNA polymerase beta for XRCC1 [PubMed10467102].

The structure of the galactose-binding domain-like members consists of a beta-sandwich, in which the strands making up the sheets exhibit a jellyroll fold. There is a high degree of similarity in the beta-sandwich and in the loops between different family members, despite an often low level of sequence similarity.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 65 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Galactose-binding domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 65 hidden Markov models representing the Galactose-binding domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]