SUPERFAMILY 1.75 HMM library and genome assignments server


SMAD/FHA domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   SMAD/FHA domain [ 49878]
Superfamily:   SMAD/FHA domain [ 49879] (4)
Families:   SMAD domain [ 49880] (4)
  FHA domain [ 49885] (11)
  Interferon regulatory factor 3 (IRF3), transactivation domain [ 101630]
  EssC N-terminal domain-like [ 141143]


Superfamily statistics
Genomes (1,753) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 16,795 35,177 38
Proteins 16,029 30,400 37


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of metabolic process0.020327.859e-05Least InformativeInherited
Biological Process (BP)growth7.378e-054.82e-07InformativeDirect
Molecular Function (MF)binding0.00093410Least InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) regulation of metabolic process 7.859e-05 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 2.806e-10 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) developmental process 1.086e-14 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 6.308e-09 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 1.461e-08 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 4.479e-07 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 3.094e-05 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.0003009 Least Informative Direct
Biological Process (BP) localization 0.2087 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.02188 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.3302 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) signal transduction 9.174e-05 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 5.177e-07 Moderately Informative Direct
Biological Process (BP) immune system process 6.009e-13 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 5.706e-09 Moderately Informative Direct
Biological Process (BP) response to organic substance 1.009e-07 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 1.17e-06 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 1.886e-06 Moderately Informative Direct
Biological Process (BP) reproduction 8.752e-06 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.0003184 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.0004977 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0.001378 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.00871 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.2628 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.1475 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.3754 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.3225 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.02302 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.8668 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.1818 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.005026 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.0837 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.2585 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.9727 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.0355 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.09135 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.007419 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.5917 Moderately Informative Inherited
Biological Process (BP) gene expression 0.8447 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.5214 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.5524 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.5808 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.8239 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.01465 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.1452 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.1426 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.7698 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.001999 Moderately Informative Inherited
Biological Process (BP) growth 4.82e-07 Informative Direct
Biological Process (BP) intracellular signal transduction 0.0009489 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 0 Informative Direct
Biological Process (BP) response to DNA damage stimulus 3.296e-14 Informative Direct
Biological Process (BP) microtubule-based process 1.054e-12 Informative Direct
Biological Process (BP) DNA metabolic process 1.151e-11 Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 5.854e-10 Informative Direct
Biological Process (BP) cell cycle process 4.869e-09 Informative Direct
Biological Process (BP) cellular process involved in reproduction 4.122e-08 Informative Direct
Biological Process (BP) chromosome organization 2.396e-07 Informative Direct
Biological Process (BP) immune effector process 2.806e-07 Informative Direct
Biological Process (BP) immune response 3.874e-07 Informative Direct
Biological Process (BP) multicellular organismal reproductive process 7.643e-07 Informative Direct
Biological Process (BP) transcription, DNA-dependent 9.433e-06 Informative Direct
Biological Process (BP) cellular component movement 1.291e-05 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 9.792e-05 Informative Direct
Biological Process (BP) tissue morphogenesis 0.0001548 Informative Direct
Biological Process (BP) cardiovascular system development 0.0002148 Informative Direct
Biological Process (BP) cellular response to endogenous stimulus 0.0002484 Informative Direct
Biological Process (BP) organelle localization 0.0002731 Informative Direct
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 0.0003556 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.0003806 Informative Direct
Biological Process (BP) regulation of growth 0.0003917 Informative Direct
Biological Process (BP) embryonic morphogenesis 0.0005158 Informative Direct
Biological Process (BP) protein catabolic process 0.0005826 Informative Direct
Biological Process (BP) tube development 0.000763 Informative Direct
Biological Process (BP) regulation of cytokine production 0.0008947 Informative Direct
Biological Process (BP) regulation of cell cycle process 0.003347 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 1 Informative Inherited
Biological Process (BP) response to cytokine stimulus 1 Informative Inherited
Biological Process (BP) defense response 0.8315 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) protein modification by small protein conjugation or removal 0.003554 Informative Inherited
Biological Process (BP) cell projection organization 0.7803 Informative Inherited
Biological Process (BP) generation of neurons 0.8849 Informative Inherited
Biological Process (BP) regulation of immune response 0.4309 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) regulation of defense response 1 Informative Inherited
Biological Process (BP) positive regulation of gene expression 0.01145 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.0567 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.1453 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.08757 Informative Inherited
Biological Process (BP) cytoskeleton organization 1 Informative Inherited
Biological Process (BP) synaptic transmission 0.07255 Informative Inherited
Biological Process (BP) organ morphogenesis 0.0878 Informative Inherited
Biological Process (BP) embryonic organ development 0.5617 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.2711 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.1333 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.05678 Informative Inherited
Biological Process (BP) negative regulation of developmental process 1 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.05393 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.6923 Informative Inherited
Biological Process (BP) locomotion 0.05738 Informative Inherited
Biological Process (BP) sexual reproduction 0.002642 Informative Inherited
Biological Process (BP) single organism reproductive process 0.009163 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.07663 Informative Inherited
Biological Process (BP) RNA processing 0.5272 Informative Inherited
Biological Process (BP) negative regulation of gene expression 0.731 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 1 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.6063 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.9314 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.03132 Informative Inherited
Biological Process (BP) response to bacterium 0.4929 Informative Inherited
Biological Process (BP) response to lipid 1 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.2122 Informative Inherited
Biological Process (BP) proteolysis 0.03828 Informative Inherited
Biological Process (BP) mitotic cell cycle 1 Informative Inherited
Biological Process (BP) sensory organ development 1 Informative Inherited
Biological Process (BP) regulation of nervous system development 1 Informative Inherited
Biological Process (BP) regulation of cell development 0.3215 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.04779 Informative Inherited
Biological Process (BP) epithelium development 0.01948 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.02263 Informative Inherited
Biological Process (BP) leukocyte activation 0.01304 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.4263 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 1 Informative Inherited
Biological Process (BP) pattern specification process 0 Highly Informative Direct
Biological Process (BP) cytoskeleton-dependent intracellular transport 3.755e-15 Highly Informative Direct
Biological Process (BP) microtubule-based movement 7.281e-13 Highly Informative Direct
Biological Process (BP) regulation of binding 5.952e-12 Highly Informative Direct
Biological Process (BP) double-strand break repair 2.705e-10 Highly Informative Direct
Biological Process (BP) regulation of striated muscle tissue development 9.583e-10 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 7.675e-09 Highly Informative Direct
Biological Process (BP) response to ionizing radiation 1.203e-08 Highly Informative Direct
Biological Process (BP) leukocyte activation involved in immune response 1.225e-08 Highly Informative Direct
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 2.338e-08 Highly Informative Direct
Biological Process (BP) protein ubiquitination 4.141e-08 Highly Informative Direct
Biological Process (BP) DNA damage checkpoint 7.123e-08 Highly Informative Direct
Biological Process (BP) regulation of striated muscle cell differentiation 1.261e-07 Highly Informative Direct
Biological Process (BP) response to lipopolysaccharide 2.24e-06 Highly Informative Direct
Biological Process (BP) developmental growth 2.926e-06 Highly Informative Direct
Biological Process (BP) DNA recombination 7.346e-06 Highly Informative Direct
Biological Process (BP) B cell activation 3.661e-05 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 4.359e-05 Highly Informative Direct
Biological Process (BP) cellular process involved in reproduction in multicellular organism 6.153e-05 Highly Informative Direct
Biological Process (BP) Golgi vesicle transport 0.0001426 Highly Informative Direct
Biological Process (BP) renal system development 0.0001476 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0.0002199 Highly Informative Direct
Biological Process (BP) regulation of DNA metabolic process 0.0009156 Highly Informative Direct
Biological Process (BP) regulation of organ morphogenesis 0.0009554 Highly Informative Direct
Biological Process (BP) regulation of innate immune response 0.001024 Highly Informative Inherited
Biological Process (BP) cytokine-mediated signaling pathway 0.7611 Highly Informative Inherited
Biological Process (BP) positive regulation of transcription, DNA-dependent 0.1143 Highly Informative Inherited
Biological Process (BP) regulation of protein complex assembly 0.03352 Highly Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 0.07696 Highly Informative Inherited
Biological Process (BP) neuron projection development 0.001266 Highly Informative Inherited
Biological Process (BP) cell part morphogenesis 0.2716 Highly Informative Inherited
Biological Process (BP) skeletal system development 0.002191 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 0.251 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.4408 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.05026 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.001026 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 0.02254 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.001449 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.1026 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.7205 Highly Informative Inherited
Biological Process (BP) negative regulation of mitotic cell cycle phase transition 0.08775 Highly Informative Inherited
Biological Process (BP) regulation of multi-organism process 0.01375 Highly Informative Inherited
Biological Process (BP) cell division 0.006958 Highly Informative Inherited
Biological Process (BP) innate immune response 1 Highly Informative Inherited
Biological Process (BP) histone modification 0.0165 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.004062 Highly Informative Inherited
Biological Process (BP) chemotaxis 0.05104 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.2042 Highly Informative Inherited
Biological Process (BP) stem cell development 0.003615 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0.4324 Highly Informative Inherited
Biological Process (BP) regulation of gene expression, epigenetic 0.9169 Highly Informative Inherited
Biological Process (BP) gene silencing 0.09714 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 0.6621 Highly Informative Inherited
Biological Process (BP) mesenchyme development 0.2299 Highly Informative Inherited
Biological Process (BP) cell growth 0.08175 Highly Informative Inherited
Biological Process (BP) limb morphogenesis 0.176 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 0.6458 Highly Informative Inherited
Biological Process (BP) stress-activated protein kinase signaling cascade 0.1097 Highly Informative Inherited
Biological Process (BP) MAPK cascade 0.1802 Highly Informative Inherited
Biological Process (BP) chromosome segregation 0.06856 Highly Informative Inherited
Biological Process (BP) mitosis 0.6952 Highly Informative Inherited
Biological Process (BP) leukocyte mediated immunity 0.007475 Highly Informative Inherited
Biological Process (BP) heart morphogenesis 0.2534 Highly Informative Inherited
Biological Process (BP) ossification 0.007345 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) hydrolase activity 0.4377 Least Informative Inherited
Molecular Function (MF) nucleic acid binding 0.0003435 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 0.8391 Moderately Informative Inherited
Molecular Function (MF) chromatin binding 8.707e-13 Informative Direct
Molecular Function (MF) nucleic acid binding transcription factor activity 2.53e-12 Informative Direct
Molecular Function (MF) DNA binding 7e-11 Informative Direct
Molecular Function (MF) nucleoside-triphosphatase activity 8.204e-06 Informative Direct
Molecular Function (MF) ligase activity 0.0001752 Informative Direct
Molecular Function (MF) enzyme binding 0.1296 Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0.5863 Informative Inherited
Molecular Function (MF) molecular transducer activity 0.1241 Informative Inherited
Molecular Function (MF) nuclease activity 0.00164 Informative Inherited
Molecular Function (MF) sequence-specific DNA binding transcription factor activity 2.127e-13 Highly Informative Direct
Molecular Function (MF) small conjugating protein ligase activity 1.797e-08 Highly Informative Direct
Molecular Function (MF) protein phosphatase binding 2.493e-06 Highly Informative Direct
Molecular Function (MF) transcription factor binding 3.144e-06 Highly Informative Direct
Molecular Function (MF) tubulin binding 1.733e-05 Highly Informative Direct
Molecular Function (MF) Ras GTPase binding 0.00075 Highly Informative Direct
Molecular Function (MF) structure-specific DNA binding 0.07087 Highly Informative Inherited
Cellular Component (CC) intracellular organelle part 6.124e-08 Least Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.0001583 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.6405 Least Informative Inherited
Cellular Component (CC) protein complex 0.001055 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) nuclear part 0.0001738 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 0.004169 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.706 Moderately Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 1.81e-09 Informative Direct
Cellular Component (CC) chromosome 6.635e-08 Informative Direct
Cellular Component (CC) nucleoplasm part 0.1149 Informative Inherited
Cellular Component (CC) cell junction 0.002768 Informative Inherited
Cellular Component (CC) microtubule associated complex 3.863e-09 Highly Informative Direct
Cellular Component (CC) adherens junction 5.01e-05 Highly Informative Direct
Cellular Component (CC) cell body 0.005847 Highly Informative Inherited
Cellular Component (CC) nuclear body 0.02065 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0.1289Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases7.375e-15Moderately InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or red8.23e-09Moderately InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation1.841e-12InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)genetic disease0.05899Moderately InformativeInherited
Disease Ontology (DO)autosomal dominant disease0.06412InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of head and neck0.1356Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the mouth0.167Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lip0.2038InformativeInherited
Phenotypic Abnormality (PA)Abnormality of upper lip0.025Highly InformativeInherited
Phenotypic Abnormality (PA)Oral cleft0.06334Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging0.09227Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.1743Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.1766Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.3797Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.6045Least InformativeInherited
Mammalian Phenotype (MP)tumorigenesis0.002617Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukopoiesis0.01232Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.02499Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system physiology0.1065Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.1397Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.148Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.4436Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune cell physiology0.4987Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell-mediated immunity0.5122Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal adaptive immunity0.5394Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell physiology0.6817Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.7064Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryogenesis/ development1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation4.285e-05InformativeDirect
Mammalian Phenotype (MP)abnormal response to radiation0.002838InformativeInherited
Mammalian Phenotype (MP)abnormal chromosome stability0.003706InformativeInherited
Mammalian Phenotype (MP)abnormal interferon secretion0.03935InformativeInherited
Mammalian Phenotype (MP)abnormal B cell physiology0.05105InformativeInherited
Mammalian Phenotype (MP)abnormal extraembryonic tissue morphology0.05303InformativeInherited
Mammalian Phenotype (MP)abnormal sensitivity to induced morbidity/mortality0.06949InformativeInherited
Mammalian Phenotype (MP)abnormal developmental patterning0.09097InformativeInherited
Mammalian Phenotype (MP)decreased leukocyte cell number0.1944InformativeInherited
Mammalian Phenotype (MP)increased malignant tumor incidence0.2409InformativeInherited
Mammalian Phenotype (MP)abnormal fertility/fecundity0.4381InformativeInherited
Mammalian Phenotype (MP)hemorrhage0.8263InformativeInherited
Mammalian Phenotype (MP)increased gonad tumor incidence4.516e-07Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mesoderm development0.0001389Highly InformativeDirect
Mammalian Phenotype (MP)decreased interferon-alpha secretion0.000147Highly InformativeDirect
Mammalian Phenotype (MP)abnormal embryonic epiblast morphology0.0002428Highly InformativeDirect
Mammalian Phenotype (MP)chromosomal instability0.000979Highly InformativeDirect
Mammalian Phenotype (MP)decreased dendritic cell number0.003742Highly InformativeInherited
Mammalian Phenotype (MP)premature aging0.004637Highly InformativeInherited
Mammalian Phenotype (MP)internal hemorrhage0.2323Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.0007819Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.006304Least InformativeInherited
Worm Phenotype (WP)pericellular component development variant0.0008956Moderately InformativeDirect
Worm Phenotype (WP)organ system development variant0.06159Moderately InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.07533Moderately InformativeInherited
Worm Phenotype (WP)male morphology variant0.0002998InformativeDirect
Worm Phenotype (WP)sensillum morphology variant0.02206InformativeInherited
Worm Phenotype (WP)organism pathogen response variant0.1066InformativeInherited
Worm Phenotype (WP)cuticle development variant2.22e-07Highly InformativeDirect
Worm Phenotype (WP)male tail morphology variant1.188e-05Highly InformativeDirect
Worm Phenotype (WP)male nervous system morphology variant3.954e-05Highly InformativeDirect
Worm Phenotype (WP)dauer development variant0.0001088Highly InformativeDirect
Worm Phenotype (WP)pathogen susceptibility increased0.0001284Highly InformativeDirect
Worm Phenotype (WP)dauer arrest variant0.0003818Highly InformativeDirect
Worm Phenotype (WP)nervous system development variant0.003015Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)mitotic cell cycle defective2.399e-06InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0.03186Least InformativeInherited
Fly Anatomy (FA)adult0.0412Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.05919Least InformativeInherited
Fly Anatomy (FA)cell0.1281Least InformativeInherited
Fly Anatomy (FA)anatomical group0.1572Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)developing material anatomical entity0Moderately InformativeDirect
Fly Anatomy (FA)peripheral nervous system0.0006715Moderately InformativeDirect
Fly Anatomy (FA)adult nervous system0.00962Moderately InformativeInherited
Fly Anatomy (FA)thoracic segment0.02108Moderately InformativeInherited
Fly Anatomy (FA)sensillum0.02789Moderately InformativeInherited
Fly Anatomy (FA)external sensory organ0.04658Moderately InformativeInherited
Fly Anatomy (FA)adult sense organ0.05204Moderately InformativeInherited
Fly Anatomy (FA)reproductive system0.05664Moderately InformativeInherited
Fly Anatomy (FA)adult head0.09821Moderately InformativeInherited
Fly Anatomy (FA)ommatidium0.0002932InformativeDirect
Fly Anatomy (FA)prepupa0.001381InformativeInherited
Fly Anatomy (FA)pupa0.001806InformativeInherited
Fly Anatomy (FA)germline stem cell0.00185InformativeInherited
Fly Anatomy (FA)ovariole0.006252InformativeInherited
Fly Anatomy (FA)imaginal precursor0.03318InformativeInherited
Fly Anatomy (FA)female germline stem cell0.0001022Highly InformativeDirect
Fly Anatomy (FA)wing disc0.0001854Highly InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0.2098Least InformativeInherited
Xenopus ANatomical entity (XAN)viscus0.9995Least InformativeInherited
Xenopus ANatomical entity (XAN)heart0.461InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups6.213e-09Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases0.06722Least InformativeInherited
Enzyme Commission (EC)Lyases0.4394Least InformativeInherited
Enzyme Commission (EC)Hydrolases0.933Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases3.887e-13Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.0002448Moderately InformativeDirect
Enzyme Commission (EC)Carbon-oxygen lyases0.08761Moderately InformativeInherited
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen4.562e-10InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation of one atom of oxygen6.578e-14Highly InformativeDirect
Enzyme Commission (EC)Other carbon-oxygen lyases4.757e-06Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCell cycle0Moderately InformativeDirect
Biological processDNA damage0Moderately InformativeDirect
Biological processTranscription regulation2.597e-07Moderately InformativeDirect
Biological processDifferentiation0.0003022Moderately InformativeDirect
Biological processMitosis1.946e-13InformativeDirect
Biological processMeiosis1.696e-10InformativeDirect
Biological processUbl conjugation pathway3.176e-10InformativeDirect
Biological processInnate immunity2.006e-09InformativeDirect
Biological processAngiogenesis2.036e-06InformativeDirect
Biological processVirulence0.0002118InformativeDirect
Biological processCell adhesion0.0005128InformativeDirect
Biological processAbscisic acid biosynthesis0Highly InformativeDirect
Biological processAntiviral defense2.925e-11Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentMicrotubule0InformativeDirect
Cellular componentChromosome2.426e-14InformativeDirect
Cellular componentTelomere2.948e-07Highly InformativeDirect
DiseaseDisease mutation0.0001377Least InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
DomainZinc-finger1.136e-11Moderately InformativeDirect
Molecular functionDNA-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionMetal-binding0.0003733Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationActivator1.474e-08Moderately InformativeDirect
Post-translational modificationDevelopmental protein1.55e-05Moderately InformativeDirect
Post-translational modificationKinase0.02737Moderately InformativeInherited
Post-translational modificationSerine/threonine-protein kinase1.299e-09InformativeDirect
Post-translational modificationChromatin regulator7.05e-08InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationAcetylation0.0001533Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationIsopeptide bond0Moderately InformativeDirect
Post-translational modificationADP-ribosylation5.322e-06InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism8.85e-11Least InformativeDirect
UniPathway (UP)protein ubiquitination9.733e-05Moderately InformativeDirect
UniPathway (UP)plant hormone metabolism0InformativeDirect
UniPathway (UP)terpene metabolism2.837e-14InformativeDirect
UniPathway (UP)plant hormone biosynthesis0Highly InformativeDirect
UniPathway (UP)sesquiterpene biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR008984 SSF49879 Protein matches
Abstract

FHA and SMAD (MH2) domains share a common structure consisting of a sandwich of eleven beta strands in two sheets with Greek key topology. Forkhead-associated (FHA) domains were originally identified as a sequence profile of about 75 amino acids, whereas the full-length domain is closer to about 150 amino acids. FHA domains are found in transcription factors, kinesin motors, and in a variety of other signalling molecules in organisms ranging from eubacteria to humans. FHA domains are protein-protein interaction domains that are specific for phosphoproteins. FHA-containing proteins function in maintaining cell-cycle checkpoints, DNA repair and transcriptional regulation. FHA domain proteins include the Chk2/Rad53/Cds1 family of proteins that contain one or more FHA domains, as well as a Ser/Thr kinase domain [PubMed11106755, PubMed12121644, PubMed12049740].

SMAD domain proteins are found in a range of species from nematodes to humans. These highly conserved proteins contain an N-terminal MH1 domain that contacts DNA, and is separated by a short linker region from the C-terminal MH2 domain, the later showing a striking similarity to FHA domains. SMAD proteins mediate signalling by the TGF-beta/activin/BMP-2/4 cytokines from receptor Ser/Thr protein kinases at the cell surface to the nucleus. SMAD proteins fall into three functional classes: the receptor-regulated SMADs (R-SMADs), including SMAD1, -2, -3, -5, and -8, each of which is involved in a ligand-specific signalling pathway [PubMed11779503]; the comediator SMADs (co-SMADs), including SMAD4, which interact with R-SMADs to participate in signalling [PubMed9214508]; and the inhibitory SMADs (I-SMADs), including SMAD6 and -7, which block the activation of R-SMADs and Co-SMADs, thereby negatively regulating signalling pathways [PubMed11483516].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 19 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a SMAD/FHA domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 19 hidden Markov models representing the SMAD/FHA domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]