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SMAD/FHA domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   SMAD/FHA domain [ 49878]
Superfamily:   SMAD/FHA domain [ 49879] (4)
Families:   SMAD domain [ 49880] (4)
  FHA domain [ 49885] (11)
  Interferon regulatory factor 3 (IRF3), transactivation domain [ 101630]
  EssC N-terminal domain-like [ 141143]


Superfamily statistics
Genomes (1,762) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 17,190 62,667 38
Proteins 16,412 59,099 37


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Cellular Component (CC)intracellular organelle part0.0067340.00006014Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.081160.2567Least InformativeInherited
Cellular Component (CC)intracellular organelle lumen0.000042480.00006596Moderately InformativeDirect
Cellular Component (CC)nuclear part0.000016710.004581Moderately InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) response to stimulus 0.000000000000007296 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.0000002709 Least Informative Direct
Biological Process (BP) macromolecule metabolic process 0.00007609 Least Informative Direct
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.689 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.05423 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.01074 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.01361 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 0.9816 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 0.09282 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.005207 Least Informative Inherited
Biological Process (BP) immune system process 0.0000000000008319 Moderately Informative Direct
Biological Process (BP) cellular localization 0.00000000005613 Moderately Informative Direct
Biological Process (BP) single organism signaling 0.0000000001243 Moderately Informative Direct
Biological Process (BP) cell communication 0.000000001305 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.0000004185 Moderately Informative Direct
Biological Process (BP) reproduction 0.0000008897 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.00001924 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0.00007784 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0.0000888 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.0002749 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.0002844 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.0003503 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 0.0009165 Moderately Informative Direct
Biological Process (BP) single-organism transport 0.581 Moderately Informative Inherited
Biological Process (BP) response to biotic stimulus 0.5799 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.002184 Moderately Informative Inherited
Biological Process (BP) defense response 0.6514 Moderately Informative Inherited
Biological Process (BP) protein complex biogenesis 0.5297 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.2179 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.7352 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.189 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.3259 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.3061 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.005796 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.001595 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.04938 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.2448 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.9564 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.002818 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.102 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.2399 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.3717 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) animal organ development 0.2927 Moderately Informative Inherited
Biological Process (BP) tissue development 0.02998 Moderately Informative Inherited
Biological Process (BP) cell cycle process 0 Informative Direct
Biological Process (BP) microtubule-based process 0 Informative Direct
Biological Process (BP) cellular response to DNA damage stimulus 0.00000000001451 Informative Direct
Biological Process (BP) regulation of cell cycle 0.00000000003998 Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.0000000002083 Informative Direct
Biological Process (BP) cell surface receptor signaling pathway 0.000000000341 Informative Direct
Biological Process (BP) organelle localization 0.0000000006611 Informative Direct
Biological Process (BP) DNA metabolic process 0.000000001392 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0.0000004476 Informative Direct
Biological Process (BP) hemopoiesis 0.000002539 Informative Direct
Biological Process (BP) growth 0.000003043 Informative Direct
Biological Process (BP) regulation of protein localization 0.0001043 Informative Direct
Biological Process (BP) immune effector process 0.000167 Informative Direct
Biological Process (BP) cell activation 0.0002215 Informative Direct
Biological Process (BP) proteolysis 0.0002487 Informative Direct
Biological Process (BP) single-organism cellular localization 0.0004509 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0.0004596 Informative Direct
Biological Process (BP) embryo development 0.0004635 Informative Direct
Biological Process (BP) phosphorylation 0.0007241 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.6908 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.1136 Informative Inherited
Biological Process (BP) positive regulation of gene expression 0.4403 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.8014 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.8375 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) intracellular transport 0.00747 Informative Inherited
Biological Process (BP) response to organic cyclic compound 1 Informative Inherited
Biological Process (BP) negative regulation of gene expression 0.9515 Informative Inherited
Biological Process (BP) protein oligomerization 0.2395 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) cell development 0.5546 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.03246 Informative Inherited
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 0.08098 Informative Inherited
Biological Process (BP) post-embryonic development 0.05902 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.4622 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.9718 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.3132 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.05076 Informative Inherited
Biological Process (BP) regulation of nervous system development 1 Informative Inherited
Biological Process (BP) regulation of growth 0.007936 Informative Inherited
Biological Process (BP) regulation of cell differentiation 0.5203 Informative Inherited
Biological Process (BP) response to nitrogen compound 1 Informative Inherited
Biological Process (BP) negative regulation of cellular protein metabolic process 0.71 Informative Inherited
Biological Process (BP) regulation of cellular amide metabolic process 1 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 1 Informative Inherited
Biological Process (BP) negative regulation of cellular biosynthetic process 0.2604 Informative Inherited
Biological Process (BP) chromosome organization 0.003495 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.1474 Informative Inherited
Biological Process (BP) multi-organism reproductive process 0.1226 Informative Inherited
Biological Process (BP) immune response 0.002753 Informative Inherited
Biological Process (BP) negative regulation of macromolecule biosynthetic process 0.09027 Informative Inherited
Biological Process (BP) regulation of organelle organization 1 Informative Inherited
Biological Process (BP) regulation of protein modification process 0.0291 Informative Inherited
Biological Process (BP) regulation of phosphorylation 0.2792 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.2578 Informative Inherited
Biological Process (BP) locomotion 0.3876 Informative Inherited
Biological Process (BP) single organism reproductive process 0.002126 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.004611 Informative Inherited
Biological Process (BP) response to radiation 0.0101 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.01782 Informative Inherited
Biological Process (BP) epithelium development 0.2302 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.05399 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.1847 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.578 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.1342 Informative Inherited
Biological Process (BP) circulatory system development 0.00216 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) response to growth factor 0 Highly Informative Direct
Biological Process (BP) establishment of organelle localization 0 Highly Informative Direct
Biological Process (BP) cell cycle checkpoint 0 Highly Informative Direct
Biological Process (BP) microtubule-based movement 0.0000000000005499 Highly Informative Direct
Biological Process (BP) lymphocyte activation 0.00000000006951 Highly Informative Direct
Biological Process (BP) cell proliferation 0.0000000007648 Highly Informative Direct
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.000000003578 Highly Informative Direct
Biological Process (BP) double-strand break repair 0.00000002826 Highly Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.0000000617 Highly Informative Direct
Biological Process (BP) DNA recombination 0.0000001866 Highly Informative Direct
Biological Process (BP) response to virus 0.0000002269 Highly Informative Direct
Biological Process (BP) cell growth 0.0000007286 Highly Informative Direct
Biological Process (BP) nuclear division 0.000001597 Highly Informative Direct
Biological Process (BP) cellular protein catabolic process 0.000002499 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 0.000003371 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.000005496 Highly Informative Direct
Biological Process (BP) regulation of fibroblast proliferation 0.00001252 Highly Informative Direct
Biological Process (BP) developmental growth involved in morphogenesis 0.00001516 Highly Informative Direct
Biological Process (BP) myeloid cell differentiation 0.00001871 Highly Informative Direct
Biological Process (BP) anatomical structure homeostasis 0.00002688 Highly Informative Direct
Biological Process (BP) germ cell development 0.00008521 Highly Informative Direct
Biological Process (BP) negative regulation of mitotic cell cycle 0.0001391 Highly Informative Direct
Biological Process (BP) amino sugar metabolic process 0.0003244 Highly Informative Direct
Biological Process (BP) regulation of chromosome organization 0.0004063 Highly Informative Direct
Biological Process (BP) protein-DNA complex subunit organization 0.0004313 Highly Informative Direct
Biological Process (BP) regulation of cell shape 0.0009717 Highly Informative Direct
Biological Process (BP) regulation of hemopoiesis 0.06494 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.521 Highly Informative Inherited
Biological Process (BP) positive regulation of transcription from RNA polymerase II promoter 1 Highly Informative Inherited
Biological Process (BP) plasma membrane bounded cell projection organization 0.00185 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 0.001841 Highly Informative Inherited
Biological Process (BP) innate immune response 0.6326 Highly Informative Inherited
Biological Process (BP) neuron development 0.549 Highly Informative Inherited
Biological Process (BP) negative regulation of phosphate metabolic process 0.02943 Highly Informative Inherited
Biological Process (BP) negative regulation of protein modification process 0.07017 Highly Informative Inherited
Biological Process (BP) cytokine-mediated signaling pathway 0.755 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular component biogenesis 0.1757 Highly Informative Inherited
Biological Process (BP) positive regulation of nervous system development 0.2653 Highly Informative Inherited
Biological Process (BP) microtubule cytoskeleton organization 0.01798 Highly Informative Inherited
Biological Process (BP) appendage development 0.02046 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.2372 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.009192 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.0419 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.00991 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 0.0684 Highly Informative Inherited
Biological Process (BP) gene silencing 0.2455 Highly Informative Inherited
Biological Process (BP) regulation of gene expression, epigenetic 0.8842 Highly Informative Inherited
Biological Process (BP) negative regulation of translation 0.3762 Highly Informative Inherited
Biological Process (BP) histone modification 0.0555 Highly Informative Inherited
Biological Process (BP) negative regulation of RNA metabolic process 0.3957 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.1027 Highly Informative Inherited
Biological Process (BP) epithelial cell differentiation 0.008969 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.3053 Highly Informative Inherited
Biological Process (BP) leukocyte differentiation 0.02076 Highly Informative Inherited
Biological Process (BP) modification-dependent macromolecule catabolic process 0.001068 Highly Informative Inherited
Biological Process (BP) gliogenesis 0.002108 Highly Informative Inherited
Biological Process (BP) post-embryonic animal morphogenesis 0.004668 Highly Informative Inherited
Biological Process (BP) cell-cell signaling 0.5201 Highly Informative Inherited
Biological Process (BP) tube morphogenesis 0.1197 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.7986 Highly Informative Inherited
Biological Process (BP) spermatogenesis 0.02102 Highly Informative Inherited
Biological Process (BP) nucleus organization 0.05621 Highly Informative Inherited
Biological Process (BP) small GTPase mediated signal transduction 0.0537 Highly Informative Inherited
Biological Process (BP) MAPK cascade 0.01331 Highly Informative Inherited
Biological Process (BP) aminoglycan biosynthetic process 0.001406 Highly Informative Inherited
Biological Process (BP) heart development 0.001117 Highly Informative Inherited
Biological Process (BP) kidney development 0.1893 Highly Informative Inherited
Biological Process (BP) sensory organ morphogenesis 0.2756 Highly Informative Inherited
Biological Process (BP) gastrulation 0.0539 Highly Informative Inherited
Biological Process (BP) protein modification by small protein conjugation 0.7795 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) hydrolase activity 0.368 Least Informative Inherited
Molecular Function (MF) transferase activity 0.983 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.000005028 Moderately Informative Direct
Molecular Function (MF) nucleic acid binding 0.0006481 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 0.8658 Moderately Informative Inherited
Molecular Function (MF) DNA binding 0.0000002581 Informative Direct
Molecular Function (MF) transcription factor activity, sequence-specific DNA binding 0.00002351 Informative Direct
Molecular Function (MF) enzyme binding 0.05065 Informative Inherited
Molecular Function (MF) ATPase activity 1 Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0.9796 Informative Inherited
Molecular Function (MF) signal transducer activity 0.2623 Informative Inherited
Molecular Function (MF) nuclease activity 0.01066 Informative Inherited
Molecular Function (MF) chromatin binding 0.000000002935 Highly Informative Direct
Molecular Function (MF) small GTPase binding 0.0000005357 Highly Informative Direct
Molecular Function (MF) ubiquitin-like protein transferase activity 0.000002066 Highly Informative Direct
Molecular Function (MF) protein phosphatase binding 0.000009771 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0.00006945 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0.0002493 Highly Informative Direct
Molecular Function (MF) deoxyribonuclease activity 0.0007954 Highly Informative Direct
Molecular Function (MF) tubulin binding 0.001084 Highly Informative Inherited
Cellular Component (CC) intracellular organelle part 0.00006014 Least Informative Direct
Cellular Component (CC) protein complex 0.0002606 Least Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0.0004 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.2567 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.00006596 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.1495 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.004581 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 1 Moderately Informative Inherited
Cellular Component (CC) vesicle 1 Moderately Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 0.0000000001174 Informative Direct
Cellular Component (CC) chromosome 0.000001076 Informative Direct
Cellular Component (CC) endosome 0.0004151 Informative Direct
Cellular Component (CC) supramolecular polymer 0.0192 Informative Inherited
Cellular Component (CC) nucleoplasm part 0.3841 Informative Inherited
Cellular Component (CC) cytoplasmic microtubule 0.000000001518 Highly Informative Direct
Cellular Component (CC) nuclear body 0.0001905 Highly Informative Direct
Cellular Component (CC) cell-cell junction 0.2625 Highly Informative Inherited
Cellular Component (CC) cell-substrate adherens junction 0.1573 Highly Informative Inherited
Cellular Component (CC) spindle 0.1371 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0.1289Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0.000000000000007375Moderately InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0.00000000823Moderately InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation0.000000000001841InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCell cycle0Moderately InformativeDirect
Biological processDNA damage0Moderately InformativeDirect
Biological processUbl conjugation pathway0.000000001122Moderately InformativeDirect
Biological processTranscription regulation0.0000004033Moderately InformativeDirect
Biological processImmunity0.000009846Moderately InformativeDirect
Biological processVirulence0.0005731Moderately InformativeDirect
Biological processDifferentiation0.0006907Moderately InformativeDirect
Biological processMitosis0.0000000000007185InformativeDirect
Biological processMeiosis0.00000000003646InformativeDirect
Biological processInnate immunity0.0000000127InformativeDirect
Biological processAngiogenesis0.000003048InformativeDirect
Biological processCell adhesion0.000734InformativeDirect
Biological processAbscisic acid biosynthesis0Highly InformativeDirect
Biological processAntiviral defense0.000000000001211Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentMicrotubule0InformativeDirect
Cellular componentChromosome0.00000000000001346InformativeDirect
Cellular componentTelomere0.0000002391Highly InformativeDirect
DiseaseDisease mutation0.0005284Least InformativeDirect
DiseaseNeurodegeneration0.000711Highly InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
DomainZinc-finger0.00000000002108Moderately InformativeDirect
Molecular functionZinc0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationDNA-binding0Moderately InformativeDirect
Post-translational modificationActivator0.00000001054Moderately InformativeDirect
Post-translational modificationDevelopmental protein0.000001992Moderately InformativeDirect
Post-translational modificationKinase0.04263Moderately InformativeInherited
Post-translational modificationSerine/threonine-protein kinase0.000000004146InformativeDirect
Post-translational modificationChromatin regulator0.0000001235InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationAcetylation0.00007033Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationIsopeptide bond0.00000000000001128Moderately InformativeDirect
Post-translational modificationADP-ribosylation0.000001064InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR008984 SSF49879 Protein matches
Abstract

FHA and SMAD (MH2) domains share a common structure consisting of a sandwich of eleven beta strands in two sheets with Greek key topology. Forkhead-associated (FHA) domains were originally identified as a sequence profile of about 75 amino acids, whereas the full-length domain is closer to about 150 amino acids. FHA domains are found in transcription factors, kinesin motors, and in a variety of other signalling molecules in organisms ranging from eubacteria to humans. FHA domains are protein-protein interaction domains that are specific for phosphoproteins. FHA-containing proteins function in maintaining cell-cycle checkpoints, DNA repair and transcriptional regulation. FHA domain proteins include the Chk2/Rad53/Cds1 family of proteins that contain one or more FHA domains, as well as a Ser/Thr kinase domain [PubMed11106755, PubMed12121644, PubMed12049740].

SMAD domain proteins are found in a range of species from nematodes to humans. These highly conserved proteins contain an N-terminal MH1 domain that contacts DNA, and is separated by a short linker region from the C-terminal MH2 domain, the later showing a striking similarity to FHA domains. SMAD proteins mediate signalling by the TGF-beta/activin/BMP-2/4 cytokines from receptor Ser/Thr protein kinases at the cell surface to the nucleus. SMAD proteins fall into three functional classes: the receptor-regulated SMADs (R-SMADs), including SMAD1, -2, -3, -5, and -8, each of which is involved in a ligand-specific signalling pathway [PubMed11779503]; the comediator SMADs (co-SMADs), including SMAD4, which interact with R-SMADs to participate in signalling [PubMed9214508]; and the inhibitory SMADs (I-SMADs), including SMAD6 and -7, which block the activation of R-SMADs and Co-SMADs, thereby negatively regulating signalling pathways [PubMed11483516].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 19 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a SMAD/FHA domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 19 hidden Markov models representing the SMAD/FHA domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]