SUPERFAMILY 1.75 HMM library and genome assignments server

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SMAD/FHA domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   SMAD/FHA domain [ 49878]
Superfamily:   SMAD/FHA domain [ 49879] (4)
Families:   SMAD domain [ 49880] (4)
  FHA domain [ 49885] (11)
  Interferon regulatory factor 3 (IRF3), transactivation domain [ 101630]
  EssC N-terminal domain-like [ 141143]


Superfamily statistics
Genomes (1,753) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 16,795 35,177 38
Proteins 16,029 30,400 37


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of metabolic process0.020510.0003276Least InformativeInherited
Biological Process (BP)growth0.00010090.0000004275InformativeDirect
Molecular Function (MF)binding0.00027640Least InformativeDirect
Cellular Component (CC)intracellular organelle part0.052770.00000004348Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.1370.6203Least InformativeInherited
Cellular Component (CC)intracellular organelle lumen0.0015120.003391Moderately InformativeInherited
Cellular Component (CC)nuclear part0.0080790.000134Moderately InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.0000000004709 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.0003276 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) developmental process 0.000000000000007318 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.000000005433 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 0.00000001255 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.0000003915 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.0000307 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.0002304 Least Informative Direct
Biological Process (BP) localization 0.1905 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.02092 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.3246 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) signal transduction 0.0000777 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.00000002669 Moderately Informative Direct
Biological Process (BP) immune system process 0.0000000000005301 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 0.000000007555 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.00000008831 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 0.00000009551 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.000008354 Moderately Informative Direct
Biological Process (BP) reproduction 0.00003413 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.000294 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.0004241 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 0.0008525 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0.001268 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.006944 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.2751 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.1317 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.3456 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.331 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.02244 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.8624 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.1595 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.00257 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.05472 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.9667 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.03031 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.1489 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.004597 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.5653 Moderately Informative Inherited
Biological Process (BP) gene expression 0.8219 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.4605 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.4925 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.5202 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.7745 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.01592 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.139 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.1323 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.7498 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.003514 Moderately Informative Inherited
Biological Process (BP) growth 0.0000004275 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 0 Informative Direct
Biological Process (BP) response to DNA damage stimulus 0.000000000000173 Informative Direct
Biological Process (BP) microtubule-based process 0.0000000000008711 Informative Direct
Biological Process (BP) DNA metabolic process 0.00000000003081 Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.000000008588 Informative Direct
Biological Process (BP) cell cycle process 0.0000000291 Informative Direct
Biological Process (BP) chromosome organization 0.0000002446 Informative Direct
Biological Process (BP) immune effector process 0.0000002801 Informative Direct
Biological Process (BP) immune response 0.000000307 Informative Direct
Biological Process (BP) cellular process involved in reproduction 0.0000003099 Informative Direct
Biological Process (BP) multicellular organismal reproductive process 0.0000007636 Informative Direct
Biological Process (BP) transcription, DNA-dependent 0.000009725 Informative Direct
Biological Process (BP) cellular component movement 0.00001114 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0.000102 Informative Direct
Biological Process (BP) tissue morphogenesis 0.0001642 Informative Direct
Biological Process (BP) cardiovascular system development 0.0002201 Informative Direct
Biological Process (BP) cellular response to endogenous stimulus 0.0002334 Informative Direct
Biological Process (BP) organelle localization 0.0002826 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.0003753 Informative Direct
Biological Process (BP) regulation of growth 0.00038 Informative Direct
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0.0004714 Informative Direct
Biological Process (BP) embryonic morphogenesis 0.0005361 Informative Direct
Biological Process (BP) protein catabolic process 0.0005828 Informative Direct
Biological Process (BP) tube development 0.0007731 Informative Direct
Biological Process (BP) sexual reproduction 0.0008173 Informative Direct
Biological Process (BP) regulation of cytokine production 0.0009447 Informative Direct
Biological Process (BP) regulation of cell cycle process 0.003238 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 1 Informative Inherited
Biological Process (BP) response to cytokine stimulus 1 Informative Inherited
Biological Process (BP) defense response 0.7823 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) protein modification by small protein conjugation or removal 0.003536 Informative Inherited
Biological Process (BP) cell projection organization 0.7628 Informative Inherited
Biological Process (BP) generation of neurons 0.8789 Informative Inherited
Biological Process (BP) regulation of immune response 0.4376 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) regulation of defense response 1 Informative Inherited
Biological Process (BP) positive regulation of gene expression 0.0129 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.05528 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.1453 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.08703 Informative Inherited
Biological Process (BP) cytoskeleton organization 1 Informative Inherited
Biological Process (BP) synaptic transmission 0.07087 Informative Inherited
Biological Process (BP) organ morphogenesis 0.08717 Informative Inherited
Biological Process (BP) embryonic organ development 0.5645 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.2749 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.1317 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.07679 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.8805 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.05614 Informative Inherited
Biological Process (BP) negative regulation of developmental process 1 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.05465 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.6982 Informative Inherited
Biological Process (BP) response to other organism 0.007824 Informative Inherited
Biological Process (BP) locomotion 0.05667 Informative Inherited
Biological Process (BP) single organism reproductive process 0.00783 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.07341 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 0.4388 Informative Inherited
Biological Process (BP) RNA processing 0.5239 Informative Inherited
Biological Process (BP) negative regulation of gene expression 0.7438 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.03379 Informative Inherited
Biological Process (BP) response to lipid 1 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.2122 Informative Inherited
Biological Process (BP) proteolysis 0.03664 Informative Inherited
Biological Process (BP) mitotic cell cycle 1 Informative Inherited
Biological Process (BP) sensory organ development 1 Informative Inherited
Biological Process (BP) regulation of nervous system development 1 Informative Inherited
Biological Process (BP) regulation of cell development 0.3058 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.0492 Informative Inherited
Biological Process (BP) epithelium development 0.01878 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.06836 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.02172 Informative Inherited
Biological Process (BP) leukocyte activation 0.01308 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.4131 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 1 Informative Inherited
Biological Process (BP) pattern specification process 0 Highly Informative Direct
Biological Process (BP) microtubule-based movement 0.0000000000007316 Highly Informative Direct
Biological Process (BP) regulation of binding 0.000000000004815 Highly Informative Direct
Biological Process (BP) regulation of striated muscle tissue development 0.0000000004619 Highly Informative Direct
Biological Process (BP) double-strand break repair 0.000000001072 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 0.000000008866 Highly Informative Direct
Biological Process (BP) leukocyte activation involved in immune response 0.00000001252 Highly Informative Direct
Biological Process (BP) DNA damage checkpoint 0.0000000228 Highly Informative Direct
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.00000002397 Highly Informative Direct
Biological Process (BP) protein ubiquitination 0.00000003778 Highly Informative Direct
Biological Process (BP) response to ionizing radiation 0.0000002015 Highly Informative Direct
Biological Process (BP) response to lipopolysaccharide 0.000002059 Highly Informative Direct
Biological Process (BP) developmental growth 0.000003741 Highly Informative Direct
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.00001341 Highly Informative Direct
Biological Process (BP) B cell activation 0.00003656 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.00004637 Highly Informative Direct
Biological Process (BP) DNA recombination 0.00004865 Highly Informative Direct
Biological Process (BP) Golgi vesicle transport 0.0001284 Highly Informative Direct
Biological Process (BP) renal system development 0.0001507 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0.000176 Highly Informative Direct
Biological Process (BP) regulation of DNA metabolic process 0.0009986 Highly Informative Direct
Biological Process (BP) regulation of innate immune response 0.001039 Highly Informative Inherited
Biological Process (BP) cytokine-mediated signaling pathway 0.7681 Highly Informative Inherited
Biological Process (BP) positive regulation of transcription, DNA-dependent 0.0301 Highly Informative Inherited
Biological Process (BP) regulation of protein complex assembly 0.03365 Highly Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 0.07313 Highly Informative Inherited
Biological Process (BP) neuron projection development 0.001264 Highly Informative Inherited
Biological Process (BP) cell part morphogenesis 0.2725 Highly Informative Inherited
Biological Process (BP) skeletal system development 0.002166 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 0.2468 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.4571 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.05225 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.001049 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 0.02275 Highly Informative Inherited
Biological Process (BP) regulation of translation 0.623 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.001382 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.09827 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.7205 Highly Informative Inherited
Biological Process (BP) negative regulation of mitotic cell cycle phase transition 0.09297 Highly Informative Inherited
Biological Process (BP) regulation of multi-organism process 0.01269 Highly Informative Inherited
Biological Process (BP) cell division 0.006617 Highly Informative Inherited
Biological Process (BP) regulation of gene expression, epigenetic 0.924 Highly Informative Inherited
Biological Process (BP) innate immune response 1 Highly Informative Inherited
Biological Process (BP) histone modification 0.01723 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.004202 Highly Informative Inherited
Biological Process (BP) chemotaxis 0.05438 Highly Informative Inherited
Biological Process (BP) gene silencing 0.09214 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.1984 Highly Informative Inherited
Biological Process (BP) stem cell development 0.00369 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0.375 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 0.6553 Highly Informative Inherited
Biological Process (BP) mesenchyme development 0.2308 Highly Informative Inherited
Biological Process (BP) cell growth 0.07658 Highly Informative Inherited
Biological Process (BP) limb morphogenesis 0.1685 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 0.6535 Highly Informative Inherited
Biological Process (BP) stress-activated protein kinase signaling cascade 0.1062 Highly Informative Inherited
Biological Process (BP) MAPK cascade 0.1876 Highly Informative Inherited
Biological Process (BP) chromosome segregation 0.06651 Highly Informative Inherited
Biological Process (BP) mitosis 0.6387 Highly Informative Inherited
Biological Process (BP) regulation of organ morphogenesis 0.001068 Highly Informative Inherited
Biological Process (BP) leukocyte mediated immunity 0.007158 Highly Informative Inherited
Biological Process (BP) heart morphogenesis 0.2547 Highly Informative Inherited
Biological Process (BP) ossification 0.007438 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) hydrolase activity 0.4335 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.00002891 Moderately Informative Direct
Molecular Function (MF) nucleic acid binding 0.0006289 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 0.8462 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding transcription factor activity 0.000000000002106 Informative Direct
Molecular Function (MF) chromatin binding 0.00000000004868 Informative Direct
Molecular Function (MF) DNA binding 0.0000000001603 Informative Direct
Molecular Function (MF) ligase activity, forming carbon-nitrogen bonds 0.000001148 Informative Direct
Molecular Function (MF) nucleoside-triphosphatase activity 0.000008057 Informative Direct
Molecular Function (MF) enzyme binding 0.1176 Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0.5739 Informative Inherited
Molecular Function (MF) molecular transducer activity 0.9414 Informative Inherited
Molecular Function (MF) nuclease activity 0.001624 Informative Inherited
Molecular Function (MF) sequence-specific DNA binding transcription factor activity 0.0000000000001808 Highly Informative Direct
Molecular Function (MF) small conjugating protein ligase activity 0.00000001763 Highly Informative Direct
Molecular Function (MF) protein phosphatase binding 0.000002487 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0.000002975 Highly Informative Direct
Molecular Function (MF) tubulin binding 0.00001749 Highly Informative Direct
Molecular Function (MF) Ras GTPase binding 0.0006842 Highly Informative Direct
Molecular Function (MF) structure-specific DNA binding 0.2202 Highly Informative Inherited
Cellular Component (CC) intracellular organelle part 0.00000004348 Least Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.000204 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.6203 Least Informative Inherited
Cellular Component (CC) protein complex 0.001002 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) nuclear part 0.000134 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 0.003391 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.7001 Moderately Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 0.000000002032 Informative Direct
Cellular Component (CC) chromosome 0.0000000642 Informative Direct
Cellular Component (CC) nucleoplasm part 0.1314 Informative Inherited
Cellular Component (CC) cell junction 0.00288 Informative Inherited
Cellular Component (CC) microtubule associated complex 0.000000004302 Highly Informative Direct
Cellular Component (CC) adherens junction 0.00004982 Highly Informative Direct
Cellular Component (CC) nuclear body 0.02122 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0.1289Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0.000000000000007375Moderately InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0.00000000823Moderately InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation0.000000000001841InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)genetic disease0.05875Moderately InformativeInherited
Disease Ontology (DO)autosomal dominant disease0.06407InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of head and neck0.1357Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the mouth0.1671Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lip0.2018InformativeInherited
Phenotypic Abnormality (PA)Abnormality of upper lip0.02443Highly InformativeInherited
Phenotypic Abnormality (PA)Oral cleft0.06443Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging0.0897Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.1737Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.3758Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.5959Least InformativeInherited
Mammalian Phenotype (MP)abnormal leukopoiesis0.01216Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.01827Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lymphocyte morphology0.06313Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system physiology0.1081Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.1373Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.184Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell morphology0.3942Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.4341Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune cell physiology0.5008Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell-mediated immunity0.5137Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal adaptive immunity0.541Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell physiology0.6816Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.8369Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal tumor incidence0.9079Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryogenesis/ development1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation0.00004337InformativeDirect
Mammalian Phenotype (MP)abnormal response to radiation0.002942InformativeInherited
Mammalian Phenotype (MP)abnormal preimplantation embryo development0.02548InformativeInherited
Mammalian Phenotype (MP)abnormal interferon secretion0.03765InformativeInherited
Mammalian Phenotype (MP)abnormal B cell physiology0.05029InformativeInherited
Mammalian Phenotype (MP)abnormal developmental patterning0.05726InformativeInherited
Mammalian Phenotype (MP)abnormal sensitivity to induced morbidity/mortality0.06791InformativeInherited
Mammalian Phenotype (MP)decreased leukocyte cell number0.193InformativeInherited
Mammalian Phenotype (MP)increased malignant tumor incidence0.2374InformativeInherited
Mammalian Phenotype (MP)decreased germ cell number0.2513InformativeInherited
Mammalian Phenotype (MP)abnormal fertility/fecundity0.4363InformativeInherited
Mammalian Phenotype (MP)hemorrhage0.8257InformativeInherited
Mammalian Phenotype (MP)increased gonad tumor incidence0.0000003468Highly InformativeDirect
Mammalian Phenotype (MP)decreased interferon-alpha secretion0.0001236Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mesoderm development0.000138Highly InformativeDirect
Mammalian Phenotype (MP)abnormal embryonic epiblast morphology0.0002227Highly InformativeDirect
Mammalian Phenotype (MP)absent primordial germ cells0.0006785Highly InformativeDirect
Mammalian Phenotype (MP)premature aging0.004632Highly InformativeInherited
Mammalian Phenotype (MP)abnormal dendritic cell number0.008327Highly InformativeInherited
Mammalian Phenotype (MP)internal hemorrhage0.2356Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.0007819Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.006304Least InformativeInherited
Worm Phenotype (WP)pericellular component development variant0.0008956Moderately InformativeDirect
Worm Phenotype (WP)organ system development variant0.06159Moderately InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.07533Moderately InformativeInherited
Worm Phenotype (WP)male morphology variant0.0002998InformativeDirect
Worm Phenotype (WP)sensillum morphology variant0.02206InformativeInherited
Worm Phenotype (WP)organism pathogen response variant0.1066InformativeInherited
Worm Phenotype (WP)cuticle development variant0.000000222Highly InformativeDirect
Worm Phenotype (WP)male tail morphology variant0.00001188Highly InformativeDirect
Worm Phenotype (WP)male nervous system morphology variant0.00003954Highly InformativeDirect
Worm Phenotype (WP)dauer development variant0.0001088Highly InformativeDirect
Worm Phenotype (WP)pathogen susceptibility increased0.0001284Highly InformativeDirect
Worm Phenotype (WP)dauer arrest variant0.0003818Highly InformativeDirect
Worm Phenotype (WP)nervous system development variant0.003015Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)mitotic cell cycle defective0.000002403InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0.03195Least InformativeInherited
Fly Anatomy (FA)adult0.0411Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.05907Least InformativeInherited
Fly Anatomy (FA)cell0.1284Least InformativeInherited
Fly Anatomy (FA)anatomical group0.1574Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)developing material anatomical entity0Moderately InformativeDirect
Fly Anatomy (FA)peripheral nervous system0.0006738Moderately InformativeDirect
Fly Anatomy (FA)adult nervous system0.009656Moderately InformativeInherited
Fly Anatomy (FA)thoracic segment0.02101Moderately InformativeInherited
Fly Anatomy (FA)sensillum0.02796Moderately InformativeInherited
Fly Anatomy (FA)external sensory organ0.0467Moderately InformativeInherited
Fly Anatomy (FA)adult sense organ0.05223Moderately InformativeInherited
Fly Anatomy (FA)reproductive system0.05676Moderately InformativeInherited
Fly Anatomy (FA)adult head0.09852Moderately InformativeInherited
Fly Anatomy (FA)ommatidium0.0002941InformativeDirect
Fly Anatomy (FA)prepupa0.001385InformativeInherited
Fly Anatomy (FA)pupa0.001812InformativeInherited
Fly Anatomy (FA)germline stem cell0.001851InformativeInherited
Fly Anatomy (FA)ovariole0.006266InformativeInherited
Fly Anatomy (FA)imaginal precursor0.0332InformativeInherited
Fly Anatomy (FA)female germline stem cell0.0001024Highly InformativeDirect
Fly Anatomy (FA)wing disc0.0001858Highly InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0.2079Least InformativeInherited
Xenopus ANatomical entity (XAN)viscus0.9996Least InformativeInherited
Xenopus ANatomical entity (XAN)heart0.4608InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0.000000006367Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases0.06595Least InformativeInherited
Enzyme Commission (EC)Lyases0.4404Least InformativeInherited
Enzyme Commission (EC)Hydrolases0.9342Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0.000000000000386Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.0002454Moderately InformativeDirect
Enzyme Commission (EC)Carbon-oxygen lyases0.08786Moderately InformativeInherited
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen0.0000000004667InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation of one atom of oxygen0.00000000000006557Highly InformativeDirect
Enzyme Commission (EC)Other carbon-oxygen lyases0.000004789Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCell cycle0Moderately InformativeDirect
Biological processDNA damage0Moderately InformativeDirect
Biological processTranscription regulation0.000000251Moderately InformativeDirect
Biological processDifferentiation0.0002862Moderately InformativeDirect
Biological processMitosis0.0000000000002455InformativeDirect
Biological processMeiosis0.0000000001651InformativeDirect
Biological processUbl conjugation pathway0.0000000003112InformativeDirect
Biological processInnate immunity0.000000002024InformativeDirect
Biological processAngiogenesis0.00000204InformativeDirect
Biological processVirulence0.0002116InformativeDirect
Biological processCell adhesion0.0005086InformativeDirect
Biological processAbscisic acid biosynthesis0Highly InformativeDirect
Biological processAntiviral defense0.00000000002622Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentMicrotubule0InformativeDirect
Cellular componentChromosome0.00000000000002418InformativeDirect
Cellular componentTelomere0.0000002976Highly InformativeDirect
DiseaseDisease mutation0.0001319Least InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
DomainZinc-finger0.00000000001179Moderately InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionMetal-binding0.000276Least InformativeDirect
Molecular functionDNA-binding0Moderately InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationActivator0.00000001472Moderately InformativeDirect
Post-translational modificationDevelopmental protein0.00001572Moderately InformativeDirect
Post-translational modificationKinase0.02725Moderately InformativeInherited
Post-translational modificationSerine/threonine-protein kinase0.000000001291InformativeDirect
Post-translational modificationChromatin regulator0.00000006526InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationAcetylation0.0001526Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationIsopeptide bond0Moderately InformativeDirect
Post-translational modificationADP-ribosylation0.000005382InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0.0000002826Least InformativeDirect
UniPathway (UP)protein ubiquitination0.0000000004862Moderately InformativeDirect
UniPathway (UP)hormone metabolism0.000000001305Moderately InformativeDirect
UniPathway (UP)plant hormone biosynthesis0.00000000008214InformativeDirect
UniPathway (UP)terpene biosynthesis0.000000002314InformativeDirect
UniPathway (UP)abscisate biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR008984 SSF49879 Protein matches
Abstract

FHA and SMAD (MH2) domains share a common structure consisting of a sandwich of eleven beta strands in two sheets with Greek key topology. Forkhead-associated (FHA) domains were originally identified as a sequence profile of about 75 amino acids, whereas the full-length domain is closer to about 150 amino acids. FHA domains are found in transcription factors, kinesin motors, and in a variety of other signalling molecules in organisms ranging from eubacteria to humans. FHA domains are protein-protein interaction domains that are specific for phosphoproteins. FHA-containing proteins function in maintaining cell-cycle checkpoints, DNA repair and transcriptional regulation. FHA domain proteins include the Chk2/Rad53/Cds1 family of proteins that contain one or more FHA domains, as well as a Ser/Thr kinase domain [PubMed11106755, PubMed12121644, PubMed12049740].

SMAD domain proteins are found in a range of species from nematodes to humans. These highly conserved proteins contain an N-terminal MH1 domain that contacts DNA, and is separated by a short linker region from the C-terminal MH2 domain, the later showing a striking similarity to FHA domains. SMAD proteins mediate signalling by the TGF-beta/activin/BMP-2/4 cytokines from receptor Ser/Thr protein kinases at the cell surface to the nucleus. SMAD proteins fall into three functional classes: the receptor-regulated SMADs (R-SMADs), including SMAD1, -2, -3, -5, and -8, each of which is involved in a ligand-specific signalling pathway [PubMed11779503]; the comediator SMADs (co-SMADs), including SMAD4, which interact with R-SMADs to participate in signalling [PubMed9214508]; and the inhibitory SMADs (I-SMADs), including SMAD6 and -7, which block the activation of R-SMADs and Co-SMADs, thereby negatively regulating signalling pathways [PubMed11483516].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 19 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a SMAD/FHA domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 19 hidden Markov models representing the SMAD/FHA domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]