SUPERFAMILY 1.75 HMM library and genome assignments server


Concanavalin A-like lectins/glucanases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Concanavalin A-like lectins/glucanases [ 49898]
Superfamily:   Concanavalin A-like lectins/glucanases [ 49899] (25)
Families:   Legume lectins [ 49900] (4)
  Lectin leg-like [ 74904] (3)
  Glycosyl hydrolases family 16 [ 49925] (5)
  Galectin (animal S-lectin) [ 49932] (8)
  Laminin G-like module [ 49944] (6)
  Thrombospondin C-terminal domain [ 101643]
  Pentraxin (pentaxin) [ 49951] (2)
  Calnexin/calreticulin [ 69236]
  vp4 sialic acid binding domain [ 74907]
  Hypothetical protein YesU [ 101646]
  Alginate lyase [ 101649] (3)
  Clostridium neurotoxins, the second last domain [ 49956] (2)
  Exotoxin A, N-terminal domain [ 49962]
  Vibrio cholerae sialidase, N-terminal and insertion domains [ 49965]
  Leech intramolecular trans-sialidase, N-terminal domain [ 49968]
  Trypanosoma sialidase, C-terminal domain [ 82038]
  Glycosyl hydrolase family 7 catalytic core [ 49971]
  Glycosyl hydrolases family 32 C-terminal domain [ 101652] (2)
  Xylanase/endoglucanase 11/12 [ 49978] (2)
  Peptidase A4 [ 101656] (2)
  Alpha-L-arabinofuranosidase B, N-terminal domain [ 110143]
  SPRY domain [ 141154] (5)
  Beta-D-xylosidase C-terminal domain-like [ 141161]
  SO2946-like [ 141167]
  MAM domain [ 141170]


Superfamily statistics
Genomes (2,142) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 56,755 76,776 236
Proteins 44,730 65,227 228


Functional annotation
General category Metabolism
Detailed category Secondary metabolism

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)developmental process0.00066680Least InformativeDirect
Biological Process (BP)single-organism cellular process6.466e-060Least InformativeDirect
Biological Process (BP)cellular component organization or biogenesis9.44e-110Least InformativeDirect
Biological Process (BP)regulation of cellular process0.89520.6507Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.0030210.6815Least InformativeInherited
Biological Process (BP)localization11.773e-12Least InformativeInherited
Biological Process (BP)multicellular organismal process0.0084770Least InformativeInherited
Biological Process (BP)carbohydrate metabolic process3.933e-121.393e-06Moderately InformativeDirect
Biological Process (BP)cell differentiation0.00087450Moderately InformativeDirect
Biological Process (BP)regulation of multicellular organismal process0.023020Moderately InformativeInherited
Biological Process (BP)cellular localization0.77280.0002623Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.85510.1063Moderately InformativeInherited
Biological Process (BP)single-organism developmental process0.54192.695e-10Moderately InformativeInherited
Biological Process (BP)tissue development0.074440.02662Moderately InformativeInherited
Biological Process (BP)organ development0.49320.08777Moderately InformativeInherited
Biological Process (BP)regulation of programmed cell death0.10880.3651Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.10570.049Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.69440.3046Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.0013877.256e-12Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.10152.083e-09Moderately InformativeInherited
Biological Process (BP)system process0.73811.297e-05Moderately InformativeInherited
Biological Process (BP)nervous system development0.84312.982e-08Moderately InformativeInherited
Biological Process (BP)cellular component biogenesis11Moderately InformativeInherited
Biological Process (BP)macromolecule catabolic process2.753e-100.01759Moderately InformativeInherited
Biological Process (BP)polysaccharide metabolic process01.002e-13InformativeDirect
Biological Process (BP)carbohydrate catabolic process5.893e-112.526e-07InformativeDirect
Biological Process (BP)transmission of nerve impulse0.00084470InformativeDirect
Biological Process (BP)biological adhesion0.0001830InformativeDirect
Biological Process (BP)membrane organization0.30290.0003631InformativeInherited
Biological Process (BP)muscle tissue development0.0013260.007295InformativeInherited
Biological Process (BP)muscle structure development0.0010610.006109InformativeInherited
Biological Process (BP)secretion by cell0.060321.825e-08InformativeInherited
Biological Process (BP)cellular carbohydrate metabolic process0.0017680.2472InformativeInherited
Biological Process (BP)regulation of cellular component biogenesis0.022321.652e-08InformativeInherited
Biological Process (BP)regulation of nervous system development0.014910.008727InformativeInherited
Biological Process (BP)cell-cell signaling0.0010932.122e-11InformativeInherited
Biological Process (BP)regulation of growth0.07573.688e-07InformativeInherited
Biological Process (BP)regulation of cell development0.020390.0004196InformativeInherited
Biological Process (BP)polysaccharide catabolic process2.989e-124.531e-13Highly InformativeDirect
Biological Process (BP)muscle organ development0.00015052.457e-06Highly InformativeDirect
Biological Process (BP)signal release0.00021061.406e-07Highly InformativeDirect
Biological Process (BP)extracellular matrix organization1.126e-050Highly InformativeDirect
Biological Process (BP)positive regulation of programmed cell death0.0005210.0004611Highly InformativeDirect
Biological Process (BP)cell wall macromolecule metabolic process04.561e-13Highly InformativeDirect
Biological Process (BP)muscle fiber development3.902e-055.084e-05Highly InformativeDirect
Biological Process (BP)regulation of mononuclear cell proliferation0.0045990.2768Highly InformativeInherited
Biological Process (BP)regulation of T cell activation0.00057041Highly InformativeInherited
Biological Process (BP)regulation of developmental growth0.0062281.359e-13Highly InformativeInherited
Molecular Function (MF)hydrolase activity0.00031550.2274Least InformativeInherited
Molecular Function (MF)binding0.069181.492e-08Least InformativeInherited
Molecular Function (MF)hydrolase activity, acting on glycosyl bonds00InformativeDirect
Molecular Function (MF)carbohydrate derivative binding0.00053941.555e-15InformativeDirect
Molecular Function (MF)transferase activity, transferring glycosyl groups1.389e-060.003066InformativeInherited
Molecular Function (MF)hydrolase activity, hydrolyzing O-glycosyl compounds00Highly InformativeDirect
Molecular Function (MF)channel regulator activity0.00043080Highly InformativeDirect
Molecular Function (MF)transferase activity, transferring hexosyl groups3.304e-080.1596Highly InformativeInherited
Cellular Component (CC)extracellular region part0.0073410Moderately InformativeInherited
Cellular Component (CC)cell surface0.00034754.261e-05InformativeDirect
Cellular Component (CC)external encapsulating structure4.593e-086.142e-06InformativeDirect
Cellular Component (CC)extracellular matrix2.344e-130InformativeDirect
Cellular Component (CC)proteinaceous extracellular matrix7.323e-090Highly InformativeDirect
Cellular Component (CC)cell wall5.507e-100.0003391Highly InformativeDirect
Cellular Component (CC)extracellular matrix part3.679e-090Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) response to stimulus 5.176e-08 Least Informative Direct
Biological Process (BP) localization 1.773e-12 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.6507 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.6815 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.1037 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) system process 1.297e-05 Moderately Informative Direct
Biological Process (BP) carbohydrate metabolic process 1.393e-06 Moderately Informative Direct
Biological Process (BP) nervous system development 2.982e-08 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 2.14e-05 Moderately Informative Direct
Biological Process (BP) cell differentiation 0 Moderately Informative Direct
Biological Process (BP) regulation of localization 2.065e-06 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 4.283e-06 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 2.695e-10 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 5.455e-07 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 7.256e-12 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 2.083e-09 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0 Moderately Informative Direct
Biological Process (BP) cellular localization 0.0002623 Moderately Informative Direct
Biological Process (BP) multi-organism process 4.835e-05 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.049 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.3046 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.1063 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.7052 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.8809 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.11 Moderately Informative Inherited
Biological Process (BP) regulation of programmed cell death 0.3651 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.02662 Moderately Informative Inherited
Biological Process (BP) organ development 0.08777 Moderately Informative Inherited
Biological Process (BP) homeostatic process 1 Moderately Informative Inherited
Biological Process (BP) macromolecule catabolic process 0.01759 Moderately Informative Inherited
Biological Process (BP) positive regulation of immune system process 2.594e-09 Informative Direct
Biological Process (BP) polysaccharide metabolic process 1.002e-13 Informative Direct
Biological Process (BP) cellular component movement 0 Informative Direct
Biological Process (BP) defense response 1.315e-09 Informative Direct
Biological Process (BP) immune response 2.019e-08 Informative Direct
Biological Process (BP) cell-cell signaling 2.122e-11 Informative Direct
Biological Process (BP) organ morphogenesis 8.482e-08 Informative Direct
Biological Process (BP) positive regulation of signal transduction 5.827e-09 Informative Direct
Biological Process (BP) carbohydrate catabolic process 2.526e-07 Informative Direct
Biological Process (BP) transmission of nerve impulse 0 Informative Direct
Biological Process (BP) biological adhesion 0 Informative Direct
Biological Process (BP) cell projection organization 0 Informative Direct
Biological Process (BP) regulation of defense response 1.9e-11 Informative Direct
Biological Process (BP) secretion by cell 1.825e-08 Informative Direct
Biological Process (BP) cellular component morphogenesis 1.923e-11 Informative Direct
Biological Process (BP) growth 0.0004319 Informative Direct
Biological Process (BP) regulation of growth 3.688e-07 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) regulation of locomotion 3.305e-09 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 1.652e-08 Informative Direct
Biological Process (BP) generation of neurons 9.269e-06 Informative Direct
Biological Process (BP) negative regulation of developmental process 7.333e-15 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 2.707e-10 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.000233 Informative Direct
Biological Process (BP) localization of cell 7.333e-15 Informative Direct
Biological Process (BP) regulation of cell development 0.0004196 Informative Direct
Biological Process (BP) membrane organization 0.0003631 Informative Direct
Biological Process (BP) cardiovascular system development 0.0005599 Informative Direct
Biological Process (BP) regulation of system process 0.3099 Informative Inherited
Biological Process (BP) negative regulation of cell death 1 Informative Inherited
Biological Process (BP) protein transport 0.2848 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 0.001516 Informative Inherited
Biological Process (BP) cation homeostasis 0.1861 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) response to organonitrogen compound 0.2584 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.5049 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.119 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.039 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.2172 Informative Inherited
Biological Process (BP) response to nutrient levels 0.4273 Informative Inherited
Biological Process (BP) metal ion transport 0.1174 Informative Inherited
Biological Process (BP) transmembrane transport 1 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.5253 Informative Inherited
Biological Process (BP) gland development 0.7579 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.00761 Informative Inherited
Biological Process (BP) sensory organ development 0.01649 Informative Inherited
Biological Process (BP) regulation of peptidase activity 0.001993 Informative Inherited
Biological Process (BP) regulation of ion transport 0.6993 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.002865 Informative Inherited
Biological Process (BP) protein complex assembly 0.1766 Informative Inherited
Biological Process (BP) regulation of secretion 0.0289 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.008727 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.2292 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 1 Informative Inherited
Biological Process (BP) muscle structure development 0.006109 Informative Inherited
Biological Process (BP) embryonic organ development 0.2661 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.8074 Informative Inherited
Biological Process (BP) single-organism behavior 0.1269 Informative Inherited
Biological Process (BP) positive regulation of cell proliferation 1 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.7399 Informative Inherited
Biological Process (BP) positive regulation of transport 0.5802 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.04418 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 0.2472 Informative Inherited
Biological Process (BP) pigment metabolic process 0.3046 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.06111 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.2758 Informative Inherited
Biological Process (BP) cell death 1 Informative Inherited
Biological Process (BP) response to bacterium 0.06303 Informative Inherited
Biological Process (BP) response to cytokine stimulus 0.5128 Informative Inherited
Biological Process (BP) chromosome organization 1 Informative Inherited
Biological Process (BP) regulation of establishment of protein localization 0.358 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 1 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 1 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.1113 Informative Inherited
Biological Process (BP) DNA metabolic process 1 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.4535 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.3219 Informative Inherited
Biological Process (BP) positive regulation of protein metabolic process 0.6034 Informative Inherited
Biological Process (BP) response to inorganic substance 1 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 1 Informative Inherited
Biological Process (BP) central nervous system development 0.9412 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 1 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.3441 Informative Inherited
Biological Process (BP) phosphorylation 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.7269 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.9989 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.2005 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.01832 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.04995 Informative Inherited
Biological Process (BP) dephosphorylation 0.08692 Informative Inherited
Biological Process (BP) muscle tissue development 0.007295 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.0185 Informative Inherited
Biological Process (BP) blood circulation 1 Informative Inherited
Biological Process (BP) cell activation 1 Informative Inherited
Biological Process (BP) immune effector process 1 Informative Inherited
Biological Process (BP) regulation of immune response 0.001289 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.2139 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.8538 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) polysaccharide catabolic process 4.531e-13 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 3.448e-08 Highly Informative Direct
Biological Process (BP) skeletal system development 0.0001107 Highly Informative Direct
Biological Process (BP) regulation of neurotransmitter levels 1.133e-12 Highly Informative Direct
Biological Process (BP) regulation of cell growth 2.978e-05 Highly Informative Direct
Biological Process (BP) tissue homeostasis 0.0001373 Highly Informative Direct
Biological Process (BP) activation of immune response 0.0001902 Highly Informative Direct
Biological Process (BP) immune response-regulating signaling pathway 4.333e-08 Highly Informative Direct
Biological Process (BP) regulation of response to biotic stimulus 2.958e-12 Highly Informative Direct
Biological Process (BP) protein dephosphorylation 8.97e-05 Highly Informative Direct
Biological Process (BP) calcium ion transport 2.417e-05 Highly Informative Direct
Biological Process (BP) neurotransmitter transport 0 Highly Informative Direct
Biological Process (BP) phagocytosis 0 Highly Informative Direct
Biological Process (BP) chemotaxis 0 Highly Informative Direct
Biological Process (BP) plasma membrane organization 1.262e-11 Highly Informative Direct
Biological Process (BP) cell adhesion 0 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 7.299e-07 Highly Informative Direct
Biological Process (BP) muscle organ development 2.457e-06 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 0.0005253 Highly Informative Direct
Biological Process (BP) regulation of cell size 8.011e-07 Highly Informative Direct
Biological Process (BP) response to purine-containing compound 3.835e-05 Highly Informative Direct
Biological Process (BP) protein ubiquitination 2.362e-11 Highly Informative Direct
Biological Process (BP) peptidyl-serine modification 2.458e-05 Highly Informative Direct
Biological Process (BP) pentose metabolic process 2.33e-06 Highly Informative Direct
Biological Process (BP) telencephalon development 0.0002576 Highly Informative Direct
Biological Process (BP) signal release 1.406e-07 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0 Highly Informative Direct
Biological Process (BP) neuron projection development 0.0002001 Highly Informative Direct
Biological Process (BP) positive regulation of defense response 2.014e-07 Highly Informative Direct
Biological Process (BP) collagen metabolic process 2.513e-08 Highly Informative Direct
Biological Process (BP) cell part morphogenesis 5.64e-10 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 0.0002582 Highly Informative Direct
Biological Process (BP) negative regulation of locomotion 3.804e-11 Highly Informative Direct
Biological Process (BP) response to drug 0.0003886 Highly Informative Direct
Biological Process (BP) defense response to bacterium 1.639e-06 Highly Informative Direct
Biological Process (BP) positive regulation of programmed cell death 0.0004611 Highly Informative Direct
Biological Process (BP) response to alkaloid 1.259e-05 Highly Informative Direct
Biological Process (BP) regulation of multi-organism process 0 Highly Informative Direct
Biological Process (BP) cell wall macromolecule metabolic process 4.561e-13 Highly Informative Direct
Biological Process (BP) multicellular organismal catabolic process 4.655e-09 Highly Informative Direct
Biological Process (BP) cellular carbohydrate catabolic process 0.0006631 Highly Informative Direct
Biological Process (BP) regulation of innate immune response 9.927e-13 Highly Informative Direct
Biological Process (BP) regulation of angiogenesis 6.357e-06 Highly Informative Direct
Biological Process (BP) negative regulation of growth 1.547e-10 Highly Informative Direct
Biological Process (BP) developmental growth 0.0001499 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 1.359e-13 Highly Informative Direct
Biological Process (BP) muscle fiber development 5.084e-05 Highly Informative Direct
Biological Process (BP) positive regulation of peptidyl-tyrosine phosphorylation 1.968e-05 Highly Informative Direct
Biological Process (BP) regulation of synaptic transmission 0.0003337 Highly Informative Direct
Biological Process (BP) negative regulation of secretion 8.375e-06 Highly Informative Direct
Biological Process (BP) positive regulation of sequence-specific DNA binding transcription factor activity 0 Highly Informative Direct
Biological Process (BP) negative regulation of protein transport 7.306e-05 Highly Informative Direct
Biological Process (BP) negative regulation of cellular component movement 0.0003132 Highly Informative Direct
Biological Process (BP) interaction with host 9.547e-05 Highly Informative Direct
Biological Process (BP) regulation of calcium ion transport 0.0006125 Highly Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 0.0004474 Highly Informative Direct
Biological Process (BP) connective tissue development 7.336e-07 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.07571 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 0.954 Highly Informative Inherited
Biological Process (BP) positive regulation of protein transport 0.0465 Highly Informative Inherited
Biological Process (BP) response to carbohydrate stimulus 0.005026 Highly Informative Inherited
Biological Process (BP) carbohydrate homeostasis 0.006747 Highly Informative Inherited
Biological Process (BP) cellular response to organic cyclic compound 0.01132 Highly Informative Inherited
Biological Process (BP) developmental maturation 0.7047 Highly Informative Inherited
Biological Process (BP) vesicle organization 0.01641 Highly Informative Inherited
Biological Process (BP) ion transmembrane transport 0.5842 Highly Informative Inherited
Biological Process (BP) regulation of hormone secretion 0.6195 Highly Informative Inherited
Biological Process (BP) regulation of peptide transport 0.2238 Highly Informative Inherited
Biological Process (BP) positive regulation of protein kinase activity 0.03786 Highly Informative Inherited
Biological Process (BP) epithelial tube morphogenesis 0.03 Highly Informative Inherited
Biological Process (BP) mammary gland epithelium development 0.00831 Highly Informative Inherited
Biological Process (BP) morphogenesis of a branching epithelium 0.1816 Highly Informative Inherited
Biological Process (BP) cellular calcium ion homeostasis 0.001023 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 0.01902 Highly Informative Inherited
Biological Process (BP) regulation of ion homeostasis 0.01211 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0.6901 Highly Informative Inherited
Biological Process (BP) regulation of protein secretion 0.0014 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.01909 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.003587 Highly Informative Inherited
Biological Process (BP) regulation of behavior 0.04072 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 0.2365 Highly Informative Inherited
Biological Process (BP) leukocyte migration 0.7383 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.7258 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.02659 Highly Informative Inherited
Biological Process (BP) regulation of mononuclear cell proliferation 0.2768 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 1 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 0.9918 Highly Informative Inherited
Biological Process (BP) positive regulation of cell activation 0.02434 Highly Informative Inherited
Biological Process (BP) positive regulation of cell differentiation 0.1388 Highly Informative Inherited
Biological Process (BP) ossification 0.01466 Highly Informative Inherited
Biological Process (BP) regulation of neuron apoptotic process 0.2275 Highly Informative Inherited
Biological Process (BP) negative regulation of endopeptidase activity 0.03065 Highly Informative Inherited
Biological Process (BP) regulation of cysteine-type endopeptidase activity 0.5002 Highly Informative Inherited
Biological Process (BP) photoreceptor cell differentiation 0.6903 Highly Informative Inherited
Biological Process (BP) myeloid cell development 0.3187 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.6438 Highly Informative Inherited
Biological Process (BP) protein methylation 0.01956 Highly Informative Inherited
Biological Process (BP) histone modification 0.9346 Highly Informative Inherited
Biological Process (BP) regulation of intracellular protein transport 0.4338 Highly Informative Inherited
Biological Process (BP) regulation of nucleocytoplasmic transport 0.3821 Highly Informative Inherited
Biological Process (BP) regulation of protein localization to nucleus 0.1749 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular transport 0.009607 Highly Informative Inherited
Biological Process (BP) glycosaminoglycan metabolic process 0.5911 Highly Informative Inherited
Biological Process (BP) multi-organism cellular process 0.1899 Highly Informative Inherited
Biological Process (BP) protein phosphorylation 1 Highly Informative Inherited
Biological Process (BP) pigment biosynthetic process 0.2717 Highly Informative Inherited
Biological Process (BP) mesenchyme development 0.04002 Highly Informative Inherited
Biological Process (BP) stem cell development 1 Highly Informative Inherited
Biological Process (BP) regulation of cell adhesion 0.04021 Highly Informative Inherited
Biological Process (BP) oligosaccharide metabolic process 0.1261 Highly Informative Inherited
Biological Process (BP) Golgi vesicle transport 0.1637 Highly Informative Inherited
Biological Process (BP) retina development in camera-type eye 0.01501 Highly Informative Inherited
Biological Process (BP) cardiac muscle tissue development 0.07554 Highly Informative Inherited
Biological Process (BP) heart morphogenesis 0.1554 Highly Informative Inherited
Biological Process (BP) regulation of blood pressure 0.225 Highly Informative Inherited
Biological Process (BP) B cell activation 0.2922 Highly Informative Inherited
Biological Process (BP) leukocyte activation involved in immune response 0.1076 Highly Informative Inherited
Biological Process (BP) renal system development 0.9328 Highly Informative Inherited
Molecular Function (MF) binding 1.492e-08 Least Informative Direct
Molecular Function (MF) hydrolase activity 0.2274 Least Informative Inherited
Molecular Function (MF) structural molecule activity 0.0004252 Moderately Informative Direct
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) enzyme regulator activity 1 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0.9991 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 1 Moderately Informative Inherited
Molecular Function (MF) cation binding 0.1136 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) receptor activity 0 Informative Direct
Molecular Function (MF) receptor binding 1.388e-07 Informative Direct
Molecular Function (MF) hydrolase activity, acting on glycosyl bonds 0 Informative Direct
Molecular Function (MF) ligase activity, forming carbon-nitrogen bonds 1.891e-14 Informative Direct
Molecular Function (MF) carboxylic acid binding 7.585e-08 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 4.46e-05 Informative Direct
Molecular Function (MF) molecular transducer activity 5.837e-09 Informative Direct
Molecular Function (MF) carbohydrate derivative binding 1.555e-15 Informative Direct
Molecular Function (MF) sulfur compound binding 1.257e-09 Informative Direct
Molecular Function (MF) inorganic cation transmembrane transporter activity 0.007741 Informative Inherited
Molecular Function (MF) enzyme inhibitor activity 0.01314 Informative Inherited
Molecular Function (MF) nucleoside-triphosphatase activity 1 Informative Inherited
Molecular Function (MF) peptidase regulator activity 0.001897 Informative Inherited
Molecular Function (MF) enzyme activator activity 0.2529 Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 0.003066 Informative Inherited
Molecular Function (MF) RNA binding 1 Informative Inherited
Molecular Function (MF) kinase activity 1 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 1 Informative Inherited
Molecular Function (MF) phosphatase activity 0.08064 Informative Inherited
Molecular Function (MF) peptidase activity 1 Informative Inherited
Molecular Function (MF) lipid binding 0.005836 Informative Inherited
Molecular Function (MF) hydrolase activity, hydrolyzing O-glycosyl compounds 0 Highly Informative Direct
Molecular Function (MF) phosphoprotein phosphatase activity 2.448e-05 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase inhibitor activity 3.461e-05 Highly Informative Direct
Molecular Function (MF) ion channel activity 0.0001142 Highly Informative Direct
Molecular Function (MF) calcium ion binding 0 Highly Informative Direct
Molecular Function (MF) heparin binding 2.484e-11 Highly Informative Direct
Molecular Function (MF) channel regulator activity 0 Highly Informative Direct
Molecular Function (MF) small conjugating protein ligase activity 0 Highly Informative Direct
Molecular Function (MF) protein kinase regulator activity 0.0002862 Highly Informative Direct
Molecular Function (MF) ion gated channel activity 1.654e-06 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase regulator activity involved in apoptotic process 2.334e-08 Highly Informative Direct
Molecular Function (MF) amino acid binding 0.006186 Highly Informative Inherited
Molecular Function (MF) transferase activity, transferring hexosyl groups 0.1596 Highly Informative Inherited
Molecular Function (MF) protein complex binding 0.002497 Highly Informative Inherited
Molecular Function (MF) protein kinase activity 1 Highly Informative Inherited
Molecular Function (MF) endopeptidase activity 0.4872 Highly Informative Inherited
Molecular Function (MF) metallopeptidase activity 0.01366 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) membrane 0.004123 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0 Moderately Informative Direct
Cellular Component (CC) endomembrane system 0.0002647 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 7.362e-05 Moderately Informative Direct
Cellular Component (CC) cell projection 2.948e-05 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) ribonucleoprotein complex 0.001977 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.7446 Moderately Informative Inherited
Cellular Component (CC) vesicle 0.00316 Moderately Informative Inherited
Cellular Component (CC) plasma membrane part 0.2115 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum membrane 5.387e-07 Informative Direct
Cellular Component (CC) cell surface 4.261e-05 Informative Direct
Cellular Component (CC) external encapsulating structure 6.142e-06 Informative Direct
Cellular Component (CC) extracellular matrix 0 Informative Direct
Cellular Component (CC) cell leading edge 1.062e-05 Informative Direct
Cellular Component (CC) synapse part 1.064e-06 Informative Direct
Cellular Component (CC) nucleoplasm part 1 Informative Inherited
Cellular Component (CC) coated vesicle 1 Informative Inherited
Cellular Component (CC) integral to membrane 0.9245 Informative Inherited
Cellular Component (CC) intrinsic to plasma membrane 0.3562 Informative Inherited
Cellular Component (CC) cell-cell junction 1 Informative Inherited
Cellular Component (CC) Golgi apparatus 0.07724 Informative Inherited
Cellular Component (CC) cytoplasmic mRNA processing body 0 Highly Informative Direct
Cellular Component (CC) proteinaceous extracellular matrix 0 Highly Informative Direct
Cellular Component (CC) cell wall 0.0003391 Highly Informative Direct
Cellular Component (CC) adherens junction 2.217e-06 Highly Informative Direct
Cellular Component (CC) sarcoplasmic reticulum 8.93e-13 Highly Informative Direct
Cellular Component (CC) extracellular matrix part 0 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 1.949e-06 Highly Informative Direct
Cellular Component (CC) synaptic membrane 5.561e-07 Highly Informative Direct
Cellular Component (CC) nuclear body 0.03731 Highly Informative Inherited
Cellular Component (CC) microvillus 0.004212 Highly Informative Inherited
Cellular Component (CC) transport vesicle 0.04349 Highly Informative Inherited
Cellular Component (CC) integral to plasma membrane 1 Highly Informative Inherited
Cellular Component (CC) ion channel complex 0.2058 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides1Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)1Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases2.215e-12Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an0.1378Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0.07915Moderately InformativeInherited
Enzyme Commission (EC)Metalloendopeptidases0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase1.837e-08InformativeDirect
Enzyme Commission (EC)Cellulose 1,4-beta-cellobiosidase (non-reducing en0Highly InformativeDirect
Enzyme Commission (EC)Bontoxilysin2.13e-13Highly InformativeDirect
Enzyme Commission (EC)Alpha-N-arabinofuranosidase0.0001267Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)