SUPERFAMILY 1.75 HMM library and genome assignments server


Concanavalin A-like lectins/glucanases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Concanavalin A-like lectins/glucanases [ 49898]
Superfamily:   Concanavalin A-like lectins/glucanases [ 49899] (25)
Families:   Legume lectins [ 49900] (4)
  Lectin leg-like [ 74904] (3)
  Glycosyl hydrolases family 16 [ 49925] (5)
  Galectin (animal S-lectin) [ 49932] (8)
  Laminin G-like module [ 49944] (6)
  Thrombospondin C-terminal domain [ 101643]
  Pentraxin (pentaxin) [ 49951] (2)
  Calnexin/calreticulin [ 69236]
  vp4 sialic acid binding domain [ 74907]
  Hypothetical protein YesU [ 101646]
  Alginate lyase [ 101649] (3)
  Clostridium neurotoxins, the second last domain [ 49956] (2)
  Exotoxin A, N-terminal domain [ 49962]
  Vibrio cholerae sialidase, N-terminal and insertion domains [ 49965]
  Leech intramolecular trans-sialidase, N-terminal domain [ 49968]
  Trypanosoma sialidase, C-terminal domain [ 82038]
  Glycosyl hydrolase family 7 catalytic core [ 49971]
  Glycosyl hydrolases family 32 C-terminal domain [ 101652] (2)
  Xylanase/endoglucanase 11/12 [ 49978] (2)
  Peptidase A4 [ 101656] (2)
  Alpha-L-arabinofuranosidase B, N-terminal domain [ 110143]
  SPRY domain [ 141154] (5)
  Beta-D-xylosidase C-terminal domain-like [ 141161]
  SO2946-like [ 141167]
  MAM domain [ 141170]


Superfamily statistics
Genomes (2,187) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 64,015 113,303 236
Proteins 50,621 98,511 228


Functional annotation
General category Metabolism
Detailed category Secondary metabolism

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular component organization or biogenesis3.139e-100Least InformativeDirect
Biological Process (BP)single-organism cellular process1.634e-050Least InformativeDirect
Biological Process (BP)developmental process0.0011440Least InformativeInherited
Biological Process (BP)regulation of cellular process0.43840.4277Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.0040340.7256Least InformativeInherited
Biological Process (BP)localization12.917e-11Least InformativeInherited
Biological Process (BP)multicellular organismal process0.013220Least InformativeInherited
Biological Process (BP)carbohydrate metabolic process5.229e-128.383e-07Moderately InformativeDirect
Biological Process (BP)regulation of multicellular organismal process3.478e-050Moderately InformativeDirect
Biological Process (BP)regulation of developmental process0.00057838.01e-11Moderately InformativeDirect
Biological Process (BP)cellular localization0.78430.0009962Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.87290.1195Moderately InformativeInherited
Biological Process (BP)cell differentiation0.0015950Moderately InformativeInherited
Biological Process (BP)single-organism developmental process0.5431.201e-11Moderately InformativeInherited
Biological Process (BP)regulation of localization0.059536.601e-07Moderately InformativeInherited
Biological Process (BP)tissue development0.081920.03047Moderately InformativeInherited
Biological Process (BP)organ development0.53780.3452Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.13040.01907Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.8030.1983Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.10317.067e-09Moderately InformativeInherited
Biological Process (BP)system process0.75116.994e-06Moderately InformativeInherited
Biological Process (BP)nervous system development0.8386.649e-09Moderately InformativeInherited
Biological Process (BP)cellular component biogenesis11Moderately InformativeInherited
Biological Process (BP)polysaccharide metabolic process06.708e-14InformativeDirect
Biological Process (BP)carbohydrate catabolic process4.56e-118.477e-08InformativeDirect
Biological Process (BP)biological adhesion0.00022280InformativeDirect
Biological Process (BP)cellular membrane organization0.42327.407e-08InformativeInherited
Biological Process (BP)synaptic transmission0.024815.104e-06InformativeInherited
Biological Process (BP)regulation of secretion7.421e-050.0033InformativeInherited
Biological Process (BP)regulation of establishment of protein localization0.20270.1559InformativeInherited
Biological Process (BP)muscle tissue development0.0015910.01167InformativeInherited
Biological Process (BP)muscle structure development0.0012530.0143InformativeInherited
Biological Process (BP)regulation of cell proliferation0.59350.001562InformativeInherited
Biological Process (BP)secretion by cell0.057665.363e-08InformativeInherited
Biological Process (BP)cellular carbohydrate metabolic process0.0019640.2148InformativeInherited
Biological Process (BP)regulation of cellular component biogenesis0.022423.1e-08InformativeInherited
Biological Process (BP)regulation of nervous system development0.035210.02274InformativeInherited
Biological Process (BP)regulation of cell development0.076020.00224InformativeInherited
Biological Process (BP)regulation of growth0.10651.421e-06InformativeInherited
Biological Process (BP)cell wall macromolecule metabolic process03.787e-14Highly InformativeDirect
Biological Process (BP)polysaccharide catabolic process2.263e-121.776e-14Highly InformativeDirect
Biological Process (BP)extracellular matrix organization1.149e-050Highly InformativeDirect
Biological Process (BP)muscle fiber development4.363e-052.442e-05Highly InformativeDirect
Biological Process (BP)muscle organ development0.00017681.965e-06Highly InformativeDirect
Biological Process (BP)signal release0.0002142.068e-07Highly InformativeDirect
Biological Process (BP)positive regulation of programmed cell death0.00057670.0004341Highly InformativeDirect
Biological Process (BP)regulation of T cell activation0.0005731Highly InformativeInherited
Biological Process (BP)regulation of mononuclear cell proliferation0.004620.1025Highly InformativeInherited
Biological Process (BP)regulation of developmental growth0.0094128.785e-14Highly InformativeInherited
Biological Process (BP)regulation of striated muscle tissue development13.758e-11Highly InformativeInherited
Molecular Function (MF)hydrolase activity0.00042280.233Least InformativeInherited
Molecular Function (MF)binding0.091734.124e-08Least InformativeInherited
Molecular Function (MF)transferase activity0.77291Least InformativeInherited
Molecular Function (MF)cation binding0.37610.07795Moderately InformativeInherited
Molecular Function (MF)hydrolase activity, acting on glycosyl bonds00InformativeDirect
Molecular Function (MF)carbohydrate derivative binding0.00054070InformativeDirect
Molecular Function (MF)transferase activity, transferring glycosyl groups2.728e-060.004843InformativeInherited
Molecular Function (MF)calcium ion binding0.00039140Highly InformativeDirect
Molecular Function (MF)channel regulator activity0.00053870Highly InformativeDirect
Molecular Function (MF)transferase activity, transferring hexosyl groups7.046e-080.1497Highly InformativeInherited
Cellular Component (CC)extracellular region part0.014730Moderately InformativeInherited
Cellular Component (CC)extracellular matrix1.677e-130InformativeDirect
Cellular Component (CC)external encapsulating structure1.58e-060.0008338InformativeDirect
Cellular Component (CC)cell surface0.00046479.036e-06InformativeDirect
Cellular Component (CC)proteinaceous extracellular matrix2.916e-090Highly InformativeDirect
Cellular Component (CC)extracellular matrix part3.339e-090Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) localization 2.917e-11 Least Informative Direct
Biological Process (BP) response to stimulus 5.188e-08 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.4277 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.7256 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.1426 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 8.383e-07 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 8.01e-11 Moderately Informative Direct
Biological Process (BP) cell differentiation 0 Moderately Informative Direct
Biological Process (BP) regulation of localization 6.601e-07 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 7.067e-09 Moderately Informative Direct
Biological Process (BP) immune system process 3.752e-15 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.000277 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 1.201e-11 Moderately Informative Direct
Biological Process (BP) system process 6.994e-06 Moderately Informative Direct
Biological Process (BP) cellular localization 0.0009962 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 1.136e-08 Moderately Informative Direct
Biological Process (BP) nervous system development 6.649e-09 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 1.921e-06 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 0.0003821 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.01907 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.1983 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.1195 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.9651 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.0618 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.03047 Moderately Informative Inherited
Biological Process (BP) organ development 0.3452 Moderately Informative Inherited
Biological Process (BP) homeostatic process 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) polysaccharide metabolic process 6.708e-14 Informative Direct
Biological Process (BP) carbohydrate catabolic process 8.477e-08 Informative Direct
Biological Process (BP) biological adhesion 0 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 3.1e-08 Informative Direct
Biological Process (BP) synaptic transmission 5.104e-06 Informative Direct
Biological Process (BP) immune response 3.595e-08 Informative Direct
Biological Process (BP) secretion by cell 5.363e-08 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.0001756 Informative Direct
Biological Process (BP) defense response 9.914e-09 Informative Direct
Biological Process (BP) regulation of growth 1.421e-06 Informative Direct
Biological Process (BP) localization of cell 1.262e-14 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) generation of neurons 1.446e-06 Informative Direct
Biological Process (BP) cellular membrane organization 7.407e-08 Informative Direct
Biological Process (BP) cellular component movement 0 Informative Direct
Biological Process (BP) cell projection organization 0 Informative Direct
Biological Process (BP) negative regulation of developmental process 1.432e-14 Informative Direct
Biological Process (BP) cellular component morphogenesis 4.384e-13 Informative Direct
Biological Process (BP) positive regulation of signal transduction 7.962e-11 Informative Direct
Biological Process (BP) regulation of defense response 3.126e-10 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 8.552e-10 Informative Direct
Biological Process (BP) positive regulation of immune system process 1.197e-09 Informative Direct
Biological Process (BP) regulation of locomotion 4.233e-09 Informative Direct
Biological Process (BP) organ morphogenesis 8.575e-07 Informative Direct
Biological Process (BP) protein modification by small protein conjugation or removal 2.991e-05 Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 0.0003283 Informative Direct
Biological Process (BP) regulation of system process 0.3614 Informative Inherited
Biological Process (BP) negative regulation of cell death 1 Informative Inherited
Biological Process (BP) protein transport 0.337 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) response to organonitrogen compound 0.3207 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.1502 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.5925 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.06008 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.2715 Informative Inherited
Biological Process (BP) response to nutrient levels 0.3309 Informative Inherited
Biological Process (BP) metal ion transport 0.1584 Informative Inherited
Biological Process (BP) transmembrane transport 1 Informative Inherited
Biological Process (BP) protein complex assembly 0.2613 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.5032 Informative Inherited
Biological Process (BP) gland development 0.8262 Informative Inherited
Biological Process (BP) tube development 0.8245 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.01879 Informative Inherited
Biological Process (BP) sensory organ development 0.02553 Informative Inherited
Biological Process (BP) regulation of peptidase activity 0.001031 Informative Inherited
Biological Process (BP) chromosome organization 1 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.007883 Informative Inherited
Biological Process (BP) regulation of cell development 0.00224 Informative Inherited
Biological Process (BP) negative regulation of transport 0.004794 Informative Inherited
Biological Process (BP) regulation of secretion 0.0033 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.02274 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 1 Informative Inherited
Biological Process (BP) muscle structure development 0.0143 Informative Inherited
Biological Process (BP) growth 0.006458 Informative Inherited
Biological Process (BP) embryonic organ development 0.3324 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.6662 Informative Inherited
Biological Process (BP) single-organism behavior 0.1986 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.7907 Informative Inherited
Biological Process (BP) positive regulation of transport 0.5788 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.1642 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 0.2148 Informative Inherited
Biological Process (BP) pigment metabolic process 0.3164 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.001562 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.06055 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.2305 Informative Inherited
Biological Process (BP) apoptotic process 0.2673 Informative Inherited
Biological Process (BP) response to other organism 0.01375 Informative Inherited
Biological Process (BP) response to cytokine stimulus 0.5588 Informative Inherited
Biological Process (BP) dephosphorylation 0.06986 Informative Inherited
Biological Process (BP) regulation of apoptotic process 1 Informative Inherited
Biological Process (BP) regulation of establishment of protein localization 0.1559 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 1 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 1 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.01587 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.4822 Informative Inherited
Biological Process (BP) positive regulation of protein modification process 0.1792 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.2064 Informative Inherited
Biological Process (BP) response to inorganic substance 1 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 1 Informative Inherited
Biological Process (BP) central nervous system development 1 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 1 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.3286 Informative Inherited
Biological Process (BP) phosphorylation 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.8172 Informative Inherited
Biological Process (BP) muscle system process 0.08442 Informative Inherited
Biological Process (BP) cation homeostasis 0.2495 Informative Inherited
Biological Process (BP) cytoplasmic transport 1 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 0.001132 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.2388 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.02464 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.019 Informative Inherited
Biological Process (BP) RNA processing 1 Informative Inherited
Biological Process (BP) ncRNA metabolic process 1 Informative Inherited
Biological Process (BP) muscle tissue development 0.01167 Informative Inherited
Biological Process (BP) cardiovascular system development 0.001045 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.05243 Informative Inherited
Biological Process (BP) blood circulation 1 Informative Inherited
Biological Process (BP) leukocyte activation 1 Informative Inherited
Biological Process (BP) immune effector process 1 Informative Inherited
Biological Process (BP) regulation of immune response 0.006826 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.2614 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.9064 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) cell wall macromolecule metabolic process 3.787e-14 Highly Informative Direct
Biological Process (BP) polysaccharide catabolic process 1.776e-14 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0 Highly Informative Direct
Biological Process (BP) muscle fiber development 2.442e-05 Highly Informative Direct
Biological Process (BP) muscle organ development 1.965e-06 Highly Informative Direct
Biological Process (BP) signal release 2.068e-07 Highly Informative Direct
Biological Process (BP) positive regulation of programmed cell death 0.0004341 Highly Informative Direct
Biological Process (BP) regulation of cytokine secretion 1.317e-07 Highly Informative Direct
Biological Process (BP) cell adhesion 0 Highly Informative Direct
Biological Process (BP) regulation of neurotransmitter levels 2.346e-12 Highly Informative Direct
Biological Process (BP) neurotransmitter transport 0 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 8.785e-14 Highly Informative Direct
Biological Process (BP) skeletal system development 0.0002231 Highly Informative Direct
Biological Process (BP) defense response to bacterium 1.612e-06 Highly Informative Direct
Biological Process (BP) positive regulation of sequence-specific DNA binding transcription factor activity 0 Highly Informative Direct
Biological Process (BP) chemotaxis 0 Highly Informative Direct
Biological Process (BP) regulation of multi-organism process 0 Highly Informative Direct
Biological Process (BP) phagocytosis 1.936e-15 Highly Informative Direct
Biological Process (BP) regulation of innate immune response 1.506e-12 Highly Informative Direct
Biological Process (BP) negative regulation of locomotion 2.175e-12 Highly Informative Direct
Biological Process (BP) protein ubiquitination 1.838e-11 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 2.802e-11 Highly Informative Direct
Biological Process (BP) regulation of striated muscle tissue development 3.758e-11 Highly Informative Direct
Biological Process (BP) cell projection morphogenesis 2.97e-08 Highly Informative Direct
Biological Process (BP) connective tissue development 1.108e-06 Highly Informative Direct
Biological Process (BP) negative regulation of cell growth 1.22e-06 Highly Informative Direct
Biological Process (BP) response to drug 1.296e-06 Highly Informative Direct
Biological Process (BP) positive regulation of defense response 1.425e-06 Highly Informative Direct
Biological Process (BP) pentose metabolic process 2.596e-06 Highly Informative Direct
Biological Process (BP) regulation of angiogenesis 5.225e-06 Highly Informative Direct
Biological Process (BP) multicellular organismal metabolic process 5.391e-06 Highly Informative Direct
Biological Process (BP) positive regulation of peptidyl-tyrosine phosphorylation 5.714e-06 Highly Informative Direct
Biological Process (BP) response to alkaloid 2.602e-05 Highly Informative Direct
Biological Process (BP) regulation of cell size 3.435e-05 Highly Informative Direct
Biological Process (BP) calcium ion transport 3.859e-05 Highly Informative Direct
Biological Process (BP) response to purine-containing compound 5.686e-05 Highly Informative Direct
Biological Process (BP) protein dephosphorylation 5.918e-05 Highly Informative Direct
Biological Process (BP) peptidyl-serine modification 7.567e-05 Highly Informative Direct
Biological Process (BP) regulation of synaptic transmission 9.69e-05 Highly Informative Direct
Biological Process (BP) axon development 0.0001029 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 0.0001289 Highly Informative Direct
Biological Process (BP) developmental growth 0.0001752 Highly Informative Direct
Biological Process (BP) negative regulation of secretion 0.0002459 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in neuron differentiation 0.0002564 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 0.0002704 Highly Informative Direct
Biological Process (BP) negative regulation of cellular component movement 0.0003567 Highly Informative Direct
Biological Process (BP) telencephalon development 0.0006925 Highly Informative Direct
Biological Process (BP) cellular carbohydrate catabolic process 0.0008573 Highly Informative Direct
Biological Process (BP) cellular calcium ion homeostasis 0.0009964 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.1028 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 1 Highly Informative Inherited
Biological Process (BP) negative regulation of apoptotic process 1 Highly Informative Inherited
Biological Process (BP) response to carbohydrate stimulus 0.005826 Highly Informative Inherited
Biological Process (BP) carbohydrate homeostasis 0.009016 Highly Informative Inherited
Biological Process (BP) developmental maturation 0.7922 Highly Informative Inherited
Biological Process (BP) vesicle organization 0.0217 Highly Informative Inherited
Biological Process (BP) positive regulation of protein kinase activity 0.04181 Highly Informative Inherited
Biological Process (BP) mammary gland epithelium development 0.006205 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 0.02195 Highly Informative Inherited
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 0.02219 Highly Informative Inherited
Biological Process (BP) protein methylation 0.05238 Highly Informative Inherited
Biological Process (BP) histone modification 1 Highly Informative Inherited
Biological Process (BP) regulation of ion homeostasis 0.02023 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.1587 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0.6274 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.005004 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.01422 Highly Informative Inherited
Biological Process (BP) regulation of behavior 0.02543 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 0.2465 Highly Informative Inherited
Biological Process (BP) leukocyte migration 0.7242 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.738 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.04654 Highly Informative Inherited
Biological Process (BP) negative regulation of cell activation 0.1044 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 1 Highly Informative Inherited
Biological Process (BP) regulation of mononuclear cell proliferation 0.1025 Highly Informative Inherited
Biological Process (BP) regulation of endocytosis 0.001092 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 0.546 Highly Informative Inherited
Biological Process (BP) positive regulation of cell activation 0.005548 Highly Informative Inherited
Biological Process (BP) ossification 0.009507 Highly Informative Inherited
Biological Process (BP) regulation of neuron apoptotic process 0.1607 Highly Informative Inherited
Biological Process (BP) negative regulation of endopeptidase activity 0.01816 Highly Informative Inherited
Biological Process (BP) regulation of cysteine-type endopeptidase activity involved in apoptotic process 0.007868 Highly Informative Inherited
Biological Process (BP) photoreceptor cell differentiation 0.8198 Highly Informative Inherited
Biological Process (BP) myeloid cell development 0.3776 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.6304 Highly Informative Inherited
Biological Process (BP) negative regulation of protein transport 0.002665 Highly Informative Inherited
Biological Process (BP) regulation of intracellular protein transport 0.8819 Highly Informative Inherited
Biological Process (BP) regulation of nucleocytoplasmic transport 0.3341 Highly Informative Inherited
Biological Process (BP) regulation of protein localization to nucleus 0.3178 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular transport 0.007669 Highly Informative Inherited
Biological Process (BP) glycosaminoglycan metabolic process 0.605 Highly Informative Inherited
Biological Process (BP) membrane fusion 1 Highly Informative Inherited
Biological Process (BP) multi-organism cellular process 0.2237 Highly Informative Inherited
Biological Process (BP) protein phosphorylation 1 Highly Informative Inherited
Biological Process (BP) pigment biosynthetic process 0.2663 Highly Informative Inherited
Biological Process (BP) mesenchyme development 0.008943 Highly Informative Inherited
Biological Process (BP) stem cell development 1 Highly Informative Inherited
Biological Process (BP) regulation of cell adhesion 0.07521 Highly Informative Inherited
Biological Process (BP) oligosaccharide metabolic process 0.1194 Highly Informative Inherited
Biological Process (BP) Golgi vesicle transport 0.09898 Highly Informative Inherited
Biological Process (BP) retina development in camera-type eye 0.006802 Highly Informative Inherited
Biological Process (BP) cardiac muscle tissue development 0.08254 Highly Informative Inherited
Biological Process (BP) heart morphogenesis 0.1884 Highly Informative Inherited
Biological Process (BP) regulation of blood pressure 0.2225 Highly Informative Inherited
Biological Process (BP) B cell activation 0.3161 Highly Informative Inherited
Biological Process (BP) leukocyte activation involved in immune response 0.1154 Highly Informative Inherited
Biological Process (BP) immune response-activating signal transduction 0.001135 Highly Informative Inherited
Biological Process (BP) RNA splicing 0.1814 Highly Informative Inherited
Molecular Function (MF) binding 4.124e-08 Least Informative Direct
Molecular Function (MF) hydrolase activity 0.233 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) structural molecule activity 0.0002706 Moderately Informative Direct
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) enzyme regulator activity 1 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 1 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 1 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 1 Moderately Informative Inherited
Molecular Function (MF) cation binding 0.07795 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on glycosyl bonds 0 Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0 Informative Direct
Molecular Function (MF) receptor activity 0 Informative Direct
Molecular Function (MF) ligase activity, forming carbon-nitrogen bonds 2.042e-14 Informative Direct
Molecular Function (MF) sulfur compound binding 2.524e-09 Informative Direct
Molecular Function (MF) molecular transducer activity 1.158e-08 Informative Direct
Molecular Function (MF) carboxylic acid binding 1.22e-07 Informative Direct
Molecular Function (MF) receptor binding 3.785e-07 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 8.393e-05 Informative Direct
Molecular Function (MF) peptidase regulator activity 0.0008334 Informative Direct
Molecular Function (MF) inorganic cation transmembrane transporter activity 0.0117 Informative Inherited
Molecular Function (MF) enzyme inhibitor activity 0.007757 Informative Inherited
Molecular Function (MF) nucleoside-triphosphatase activity 1 Informative Inherited
Molecular Function (MF) enzyme activator activity 0.2814 Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 0.004843 Informative Inherited
Molecular Function (MF) RNA binding 1 Informative Inherited
Molecular Function (MF) kinase activity 1 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 1 Informative Inherited
Molecular Function (MF) phosphoric ester hydrolase activity 0.4553 Informative Inherited
Molecular Function (MF) lipid binding 0.006598 Informative Inherited
Molecular Function (MF) calcium ion binding 0 Highly Informative Direct
Molecular Function (MF) channel regulator activity 0 Highly Informative Direct
Molecular Function (MF) small conjugating protein ligase activity 0 Highly Informative Direct
Molecular Function (MF) calcium ion transmembrane transporter activity 8.193e-13 Highly Informative Direct
Molecular Function (MF) heparin binding 4.165e-11 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase regulator activity involved in apoptotic process 2.232e-08 Highly Informative Direct
Molecular Function (MF) cation channel activity 1.515e-06 Highly Informative Direct
Molecular Function (MF) ion gated channel activity 3.725e-06 Highly Informative Direct
Molecular Function (MF) phosphoprotein phosphatase activity 3.693e-05 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase inhibitor activity 0.0001793 Highly Informative Direct
Molecular Function (MF) protein kinase regulator activity 0.000328 Highly Informative Direct
Molecular Function (MF) amino acid binding 0.006162 Highly Informative Inherited
Molecular Function (MF) transferase activity, transferring hexosyl groups 0.1497 Highly Informative Inherited
Molecular Function (MF) protein complex binding 0.004214 Highly Informative Inherited
Molecular Function (MF) protein kinase activity 1 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) membrane 0.03361 Least Informative Inherited
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) vesicle 1.436e-05 Moderately Informative Direct
Cellular Component (CC) endoplasmic reticulum 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane 1.07e-05 Moderately Informative Direct
Cellular Component (CC) cell projection 4.67e-05 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 0.0002551 Moderately Informative Direct
Cellular Component (CC) endomembrane system 0.0005675 Moderately Informative Direct
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) ribonucleoprotein complex 0.003024 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.8768 Moderately Informative Inherited
Cellular Component (CC) extracellular matrix 0 Informative Direct
Cellular Component (CC) external encapsulating structure 0.0008338 Informative Direct
Cellular Component (CC) cell surface 9.036e-06 Informative Direct
Cellular Component (CC) extracellular membrane-bounded organelle 1.137e-06 Informative Direct
Cellular Component (CC) synapse part 2.341e-07 Informative Direct
Cellular Component (CC) endoplasmic reticulum membrane 6.442e-07 Informative Direct
Cellular Component (CC) cell leading edge 1.526e-05 Informative Direct
Cellular Component (CC) nucleoplasm part 1 Informative Inherited
Cellular Component (CC) coated vesicle 1 Informative Inherited
Cellular Component (CC) intrinsic to plasma membrane 0.2529 Informative Inherited
Cellular Component (CC) integral to membrane 0.9258 Informative Inherited
Cellular Component (CC) cell-cell junction 1 Informative Inherited
Cellular Component (CC) Golgi apparatus 0.00829 Informative Inherited
Cellular Component (CC) proteinaceous extracellular matrix 0 Highly Informative Direct
Cellular Component (CC) extracellular matrix part 0 Highly Informative Direct
Cellular Component (CC) cytoplasmic mRNA processing body 0 Highly Informative Direct
Cellular Component (CC) sarcoplasmic reticulum 3.996e-12 Highly Informative Direct
Cellular Component (CC) adherens junction 1.729e-06 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 2.701e-06 Highly Informative Direct
Cellular Component (CC) sarcolemma 0.0007123 Highly Informative Direct
Cellular Component (CC) nuclear body 0.009035 Highly Informative Inherited
Cellular Component (CC) transport vesicle 0.06301 Highly Informative Inherited
Cellular Component (CC) ion channel complex 0.2331 Highly Informative Inherited
Cellular Component (CC) integral to plasma membrane 1 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides1Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)1Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases2.215e-12Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an0.1378Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0.07915Moderately InformativeInherited
Enzyme Commission (EC)Metalloendopeptidases0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase1.837e-08InformativeDirect
Enzyme Commission (EC)Cellulose 1,4-beta-cellobiosidase (non-reducing en0Highly InformativeDirect
Enzyme Commission (EC)Bontoxilysin2.13e-13Highly InformativeDirect
Enzyme Commission (EC)Alpha-N-arabinofuranosidase0.0001267Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)