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Concanavalin A-like lectins/glucanases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Concanavalin A-like lectins/glucanases [ 49898]
Superfamily:   Concanavalin A-like lectins/glucanases [ 49899] (25)
Families:   Legume lectins [ 49900] (4)
  Lectin leg-like [ 74904] (3)
  Glycosyl hydrolases family 16 [ 49925] (5)
  Galectin (animal S-lectin) [ 49932] (8)
  Laminin G-like module [ 49944] (6)
  Thrombospondin C-terminal domain [ 101643]
  Pentraxin (pentaxin) [ 49951] (2)
  Calnexin/calreticulin [ 69236]
  vp4 sialic acid binding domain [ 74907]
  Hypothetical protein YesU [ 101646]
  Alginate lyase [ 101649] (3)
  Clostridium neurotoxins, the second last domain [ 49956] (2)
  Exotoxin A, N-terminal domain [ 49962]
  Vibrio cholerae sialidase, N-terminal and insertion domains [ 49965]
  Leech intramolecular trans-sialidase, N-terminal domain [ 49968]
  Trypanosoma sialidase, C-terminal domain [ 82038]
  Glycosyl hydrolase family 7 catalytic core [ 49971]
  Glycosyl hydrolases family 32 C-terminal domain [ 101652] (2)
  Xylanase/endoglucanase 11/12 [ 49978] (2)
  Peptidase A4 [ 101656] (2)
  Alpha-L-arabinofuranosidase B, N-terminal domain [ 110143]
  SPRY domain [ 141154] (5)
  Beta-D-xylosidase C-terminal domain-like [ 141161]
  SO2946-like [ 141167]
  MAM domain [ 141170]


Superfamily statistics
Genomes (2,197) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 65,045 218,043 236
Proteins 51,285 178,760 228


Functional annotation
General category Metabolism
Detailed category Secondary metabolism

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biological regulation0.7310.0002752Least InformativeInherited
Biological Process (BP)single-organism cellular process10.007479Least InformativeInherited
Biological Process (BP)macromolecule metabolic process0.2010.8951Least InformativeInherited
Biological Process (BP)primary metabolic process11Least InformativeInherited
Biological Process (BP)multicellular organismal process0.11110Least InformativeInherited
Biological Process (BP)carbohydrate metabolic process0.0000000078830.00001066Moderately InformativeDirect
Biological Process (BP)regulation of multicellular organismal process0.0000083540.000000000003208Moderately InformativeDirect
Biological Process (BP)regulation of developmental process0.00078890.00000004142Moderately InformativeDirect
Biological Process (BP)regulation of localization0.082320.00001281Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.024870.00000000002486Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.052671Moderately InformativeInherited
Biological Process (BP)cell differentiation0.59390.0003318Moderately InformativeInherited
Biological Process (BP)tissue development0.89261Moderately InformativeInherited
Biological Process (BP)animal organ development0.93460.7924Moderately InformativeInherited
Biological Process (BP)polysaccharide metabolic process00.00000000003876InformativeDirect
Biological Process (BP)carbohydrate catabolic process0.000000011270.000003266InformativeDirect
Biological Process (BP)regulation of secretion0.00079230.01601InformativeInherited
Biological Process (BP)regulation of peptide transport0.003610.3623InformativeInherited
Biological Process (BP)regulation of cytokine production0.0043750.002058InformativeInherited
Biological Process (BP)regulation of protein localization0.014770.5324InformativeInherited
Biological Process (BP)regulation of cell proliferation0.43620.04342InformativeInherited
Biological Process (BP)cell development0.14760.0000000003789InformativeInherited
Biological Process (BP)circulatory system development0.02320.0001821InformativeInherited
Biological Process (BP)anatomical structure formation involved in morphogenesis0.00024580.002341InformativeInherited
Biological Process (BP)cell wall macromolecule metabolic process00Highly InformativeDirect
Biological Process (BP)polysaccharide catabolic process0.0000000020880.000000001258Highly InformativeDirect
Biological Process (BP)angiogenesis0.0000018030.000000001994Highly InformativeDirect
Biological Process (BP)muscle organ development0.000014430.00003148Highly InformativeDirect
Biological Process (BP)regulation of cytokine secretion0.00040110.00000001144Highly InformativeDirect
Biological Process (BP)regulation of T cell activation0.0010061Highly InformativeInherited
Biological Process (BP)regulation of lymphocyte proliferation0.3991Highly InformativeInherited
Biological Process (BP)striated muscle cell development0.0001580.2095Highly InformativeInherited
Biological Process (BP)muscle tissue development0.00037720.1706Highly InformativeInherited
Molecular Function (MF)binding0.26710.09314Least InformativeInherited
Molecular Function (MF)transferase activity11Least InformativeInherited
Molecular Function (MF)hydrolase activity0.030470.918Least InformativeInherited
Molecular Function (MF)carbohydrate derivative binding0.0084080.0000738Moderately InformativeInherited
Molecular Function (MF)small molecule binding0.19651Moderately InformativeInherited
Molecular Function (MF)metal ion binding0.52560.00757Moderately InformativeInherited
Molecular Function (MF)hydrolase activity, acting on glycosyl bonds00InformativeDirect
Molecular Function (MF)transferase activity, transferring glycosyl groups0.03970.05063InformativeInherited
Molecular Function (MF)hydrolase activity, hydrolyzing O-glycosyl compounds00Highly InformativeDirect
Molecular Function (MF)monosaccharide binding0.000022590.0001172Highly InformativeDirect
Molecular Function (MF)calcium ion binding0.00061360Highly InformativeDirect
Molecular Function (MF)transferase activity, transferring hexosyl groups0.0068860.1796Highly InformativeInherited
Cellular Component (CC)extracellular region part0.64420Moderately InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) biological regulation 0.0002752 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) response to stimulus 0.000006544 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.007479 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 0.8951 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.00001066 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.000000000003208 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.00000004142 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.00000000002486 Moderately Informative Direct
Biological Process (BP) defense response 0 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.00001281 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0.000000001657 Moderately Informative Direct
Biological Process (BP) response to biotic stimulus 0.00001882 Moderately Informative Direct
Biological Process (BP) response to external stimulus 0 Moderately Informative Direct
Biological Process (BP) immune system process 0.00000000000001763 Moderately Informative Direct
Biological Process (BP) cell differentiation 0.0003318 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 0.000000000000001925 Moderately Informative Direct
Biological Process (BP) regulation of signaling 0.000000000000007296 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.0001425 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.007643 Moderately Informative Inherited
Biological Process (BP) single organism signaling 0.01257 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.3858 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) animal organ development 0.7924 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.071 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.003508 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.009991 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.1134 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.0437 Moderately Informative Inherited
Biological Process (BP) cell communication 0.001727 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.284 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.004891 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) polysaccharide metabolic process 0.00000000003876 Informative Direct
Biological Process (BP) carbohydrate catabolic process 0.000003266 Informative Direct
Biological Process (BP) circulatory system development 0.0001821 Informative Direct
Biological Process (BP) immune response 0.0000005473 Informative Direct
Biological Process (BP) cellular component morphogenesis 0 Informative Direct
Biological Process (BP) regulation of immune response 0.00001999 Informative Direct
Biological Process (BP) cell development 0.0000000003789 Informative Direct
Biological Process (BP) positive regulation of immune system process 0.00000000502 Informative Direct
Biological Process (BP) defense response to other organism 0.000005191 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0 Informative Direct
Biological Process (BP) localization of cell 0.00000000000003598 Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.00000000000005058 Informative Direct
Biological Process (BP) regulation of defense response 0.000000000002703 Informative Direct
Biological Process (BP) positive regulation of signal transduction 0.00000000005455 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.0000000003227 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0.000000005546 Informative Direct
Biological Process (BP) regulation of locomotion 0.00000000922 Informative Direct
Biological Process (BP) positive regulation of phosphate metabolic process 0.000005155 Informative Direct
Biological Process (BP) single-organism membrane organization 0.00001096 Informative Direct
Biological Process (BP) positive regulation of cellular protein metabolic process 0.00006123 Informative Direct
Biological Process (BP) regulation of growth 0.0001691 Informative Direct
Biological Process (BP) regulation of protein modification process 0.0002479 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.0008043 Informative Direct
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) negative regulation of cell death 1 Informative Inherited
Biological Process (BP) regulation of apoptotic process 1 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.2813 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.001115 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 1 Informative Inherited
Biological Process (BP) generation of neurons 0.1059 Informative Inherited
Biological Process (BP) regulation of protein localization 0.5324 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.02661 Informative Inherited
Biological Process (BP) organelle assembly 1 Informative Inherited
Biological Process (BP) regulation of cellular localization 0.587 Informative Inherited
Biological Process (BP) organic acid transport 0.9165 Informative Inherited
Biological Process (BP) anion transport 1 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.3003 Informative Inherited
Biological Process (BP) response to nitrogen compound 1 Informative Inherited
Biological Process (BP) response to extracellular stimulus 1 Informative Inherited
Biological Process (BP) cellular response to inorganic substance 0.1281 Informative Inherited
Biological Process (BP) metal ion transport 0.5027 Informative Inherited
Biological Process (BP) regulation of transferase activity 0.865 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 1 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) cation homeostasis 0.3872 Informative Inherited
Biological Process (BP) inorganic ion homeostasis 0.4223 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.002341 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 0.1462 Informative Inherited
Biological Process (BP) response to metal ion 0.8787 Informative Inherited
Biological Process (BP) transmembrane transport 1 Informative Inherited
Biological Process (BP) regulation of secretion 0.01601 Informative Inherited
Biological Process (BP) response to bacterium 0.2802 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.3047 Informative Inherited
Biological Process (BP) negative regulation of transport 0.004219 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.002058 Informative Inherited
Biological Process (BP) embryo development 1 Informative Inherited
Biological Process (BP) single-organism cellular localization 0.9745 Informative Inherited
Biological Process (BP) intracellular transport 1 Informative Inherited
Biological Process (BP) organelle localization 1 Informative Inherited
Biological Process (BP) lipid localization 1 Informative Inherited
Biological Process (BP) interspecies interaction between organisms 1 Informative Inherited
Biological Process (BP) negative regulation of cellular protein metabolic process 0.2124 Informative Inherited
Biological Process (BP) positive regulation of transport 0.5801 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.1806 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.2039 Informative Inherited
Biological Process (BP) regulation of cell differentiation 0.005232 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 1 Informative Inherited
Biological Process (BP) regulation of proteolysis 0.1133 Informative Inherited
Biological Process (BP) negative regulation of molecular function 1 Informative Inherited
Biological Process (BP) regulation of phosphorylation 0.01683 Informative Inherited
Biological Process (BP) chromosome organization 1 Informative Inherited
Biological Process (BP) regulation of peptide transport 0.3623 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.1373 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 1 Informative Inherited
Biological Process (BP) supramolecular fiber organization 0.4547 Informative Inherited
Biological Process (BP) central nervous system development 1 Informative Inherited
Biological Process (BP) monosaccharide metabolic process 0.2937 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.3551 Informative Inherited
Biological Process (BP) phosphorylation 1 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.01421 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.003575 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 0.1844 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.2545 Informative Inherited
Biological Process (BP) response to radiation 1 Informative Inherited
Biological Process (BP) behavior 0.09129 Informative Inherited
Biological Process (BP) secretion by cell 0.06636 Informative Inherited
Biological Process (BP) pigment metabolic process 0.175 Informative Inherited
Biological Process (BP) tRNA metabolic process 0.7998 Informative Inherited
Biological Process (BP) ncRNA processing 1 Informative Inherited
Biological Process (BP) growth 0.3043 Informative Inherited
Biological Process (BP) system process 0.5508 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.04342 Informative Inherited
Biological Process (BP) response to wounding 0.6676 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 0.002208 Informative Inherited
Biological Process (BP) cell wall macromolecule metabolic process 0 Highly Informative Direct
Biological Process (BP) polysaccharide catabolic process 0.000000001258 Highly Informative Direct
Biological Process (BP) angiogenesis 0.000000001994 Highly Informative Direct
Biological Process (BP) muscle organ development 0.00003148 Highly Informative Direct
Biological Process (BP) regulation of cytokine secretion 0.00000001144 Highly Informative Direct
Biological Process (BP) biological adhesion 0 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 0 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 0 Highly Informative Direct
Biological Process (BP) neuron development 0 Highly Informative Direct
Biological Process (BP) positive regulation of sequence-specific DNA binding transcription factor activity 0 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0 Highly Informative Direct
Biological Process (BP) regulation of viral process 0.000000000000007296 Highly Informative Direct
Biological Process (BP) phagocytosis 0.00000000000005703 Highly Informative Direct
Biological Process (BP) negative regulation of locomotion 0.000000000009979 Highly Informative Direct
Biological Process (BP) cell-cell signaling 0.0000000002442 Highly Informative Direct
Biological Process (BP) activation of innate immune response 0.0000000009564 Highly Informative Direct
Biological Process (BP) response to drug 0.00000003891 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.0000002423 Highly Informative Direct
Biological Process (BP) negative regulation of multi-organism process 0.0000004777 Highly Informative Direct
Biological Process (BP) negative regulation of secretion by cell 0.000000493 Highly Informative Direct
Biological Process (BP) negative regulation of cellular component movement 0.000001106 Highly Informative Direct
Biological Process (BP) negative regulation of growth 0.000001294 Highly Informative Direct
Biological Process (BP) protein modification by small protein conjugation 0.000004035 Highly Informative Direct
Biological Process (BP) vasculogenesis 0.000006142 Highly Informative Direct
Biological Process (BP) regulation of interleukin-1 production 0.000008591 Highly Informative Direct
Biological Process (BP) cellular response to calcium ion 0.00002438 Highly Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 0.00003046 Highly Informative Direct
Biological Process (BP) positive regulation of MAPK cascade 0.00003384 Highly Informative Direct
Biological Process (BP) positive regulation of intracellular transport 0.00005031 Highly Informative Direct
Biological Process (BP) negative regulation of sequence-specific DNA binding transcription factor activity 0.00005707 Highly Informative Direct
Biological Process (BP) protein localization to membrane 0.0001055 Highly Informative Direct
Biological Process (BP) regulation of ion homeostasis 0.0001298 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.0001337 Highly Informative Direct
Biological Process (BP) regulation of fibroblast proliferation 0.0001511 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 0.0001517 Highly Informative Direct
Biological Process (BP) muscle system process 0.0001519 Highly Informative Direct
Biological Process (BP) negative regulation of nervous system development 0.0002184 Highly Informative Direct
Biological Process (BP) protein dephosphorylation 0.0002371 Highly Informative Direct
Biological Process (BP) regulation of neurotransmitter levels 0.0002708 Highly Informative Direct
Biological Process (BP) gastrulation 0.0003267 Highly Informative Direct
Biological Process (BP) negative regulation of establishment of protein localization 0.0004229 Highly Informative Direct
Biological Process (BP) regulation of cell size 0.0004456 Highly Informative Direct
Biological Process (BP) oligosaccharide catabolic process 0.000546 Highly Informative Direct
Biological Process (BP) regulation of epithelial cell migration 0.0005845 Highly Informative Direct
Biological Process (BP) negative regulation of apoptotic process 1 Highly Informative Inherited
Biological Process (BP) negative regulation of endopeptidase activity 0.008127 Highly Informative Inherited
Biological Process (BP) regulation of cysteine-type endopeptidase activity 0.9686 Highly Informative Inherited
Biological Process (BP) regulation of hemopoiesis 0.8432 Highly Informative Inherited
Biological Process (BP) inorganic cation transmembrane transport 0.01197 Highly Informative Inherited
Biological Process (BP) negative regulation of peptide secretion 0.001444 Highly Informative Inherited
Biological Process (BP) leukocyte migration 1 Highly Informative Inherited
Biological Process (BP) organic hydroxy compound transport 0.3524 Highly Informative Inherited
Biological Process (BP) monocarboxylic acid transport 0.05099 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 1 Highly Informative Inherited
Biological Process (BP) response to carbohydrate 0.005868 Highly Informative Inherited
Biological Process (BP) carbohydrate homeostasis 0.00845 Highly Informative Inherited
Biological Process (BP) cellular response to organonitrogen compound 0.5064 Highly Informative Inherited
Biological Process (BP) cellular response to extracellular stimulus 1 Highly Informative Inherited
Biological Process (BP) autophagy 0.1716 Highly Informative Inherited
Biological Process (BP) kidney development 0.9195 Highly Informative Inherited
Biological Process (BP) cellular calcium ion homeostasis 0.001495 Highly Informative Inherited
Biological Process (BP) heart development 1 Highly Informative Inherited
Biological Process (BP) innate immune response 0.1373 Highly Informative Inherited
Biological Process (BP) cytokine-mediated signaling pathway 0.4039 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular component biogenesis 0.02877 Highly Informative Inherited
Biological Process (BP) positive regulation of nervous system development 0.3273 Highly Informative Inherited
Biological Process (BP) peptidyl-lysine modification 0.9671 Highly Informative Inherited
Biological Process (BP) histone modification 1 Highly Informative Inherited
Biological Process (BP) negative regulation of homeostatic process 0.002365 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.1137 Highly Informative Inherited
Biological Process (BP) camera-type eye development 0.847 Highly Informative Inherited
Biological Process (BP) sensory organ morphogenesis 0.008618 Highly Informative Inherited
Biological Process (BP) establishment of organelle localization 0.8062 Highly Informative Inherited
Biological Process (BP) regulation of intracellular protein transport 0.594 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular protein localization 0.02132 Highly Informative Inherited
Biological Process (BP) positive regulation of protein transport 0.6151 Highly Informative Inherited
Biological Process (BP) regulation of nucleocytoplasmic transport 0.2 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular transport 0.004966 Highly Informative Inherited
Biological Process (BP) pigmentation 0.01916 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 1 Highly Informative Inherited
Biological Process (BP) regulation of lymphocyte proliferation 1 Highly Informative Inherited
Biological Process (BP) multicellular organism metabolic process 0.001389 Highly Informative Inherited
Biological Process (BP) anatomical structure maturation 0.1494 Highly Informative Inherited
Biological Process (BP) appendage development 1 Highly Informative Inherited
Biological Process (BP) protein alkylation 0.1477 Highly Informative Inherited
Biological Process (BP) macromolecule methylation 0.5342 Highly Informative Inherited
Biological Process (BP) response to nutrient levels 1 Highly Informative Inherited
Biological Process (BP) response to organophosphorus 0.1295 Highly Informative Inherited
Biological Process (BP) regulation of protein localization to nucleus 0.007127 Highly Informative Inherited
Biological Process (BP) regulation of protein import 0.05588 Highly Informative Inherited
Biological Process (BP) positive regulation of lymphocyte activation 0.791 Highly Informative Inherited
Biological Process (BP) negative regulation of cytokine production 0.2114 Highly Informative Inherited
Biological Process (BP) activation of protein kinase activity 0.003318 Highly Informative Inherited
Biological Process (BP) response to purine-containing compound 0.001402 Highly Informative Inherited
Biological Process (BP) embryonic organ development 0.7904 Highly Informative Inherited
Biological Process (BP) cell chemotaxis 0.1453 Highly Informative Inherited
Biological Process (BP) regulation of cell growth 0.00593 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.8705 Highly Informative Inherited
Biological Process (BP) forebrain development 1 Highly Informative Inherited
Biological Process (BP) nervous system process 1 Highly Informative Inherited
Biological Process (BP) viral process 0.4829 Highly Informative Inherited
Biological Process (BP) multi-organism cellular process 0.07752 Highly Informative Inherited
Biological Process (BP) macromolecule glycosylation 0.2702 Highly Informative Inherited
Biological Process (BP) striated muscle cell development 0.2095 Highly Informative Inherited
Biological Process (BP) muscle tissue development 0.1706 Highly Informative Inherited
Biological Process (BP) gliogenesis 1 Highly Informative Inherited
Biological Process (BP) negative regulation of cell development 0.003315 Highly Informative Inherited
Biological Process (BP) glycoprotein metabolic process 0.241 Highly Informative Inherited
Biological Process (BP) single-organism behavior 0.003026 Highly Informative Inherited
Biological Process (BP) plasma membrane bounded cell projection organization 0.02228 Highly Informative Inherited
Biological Process (BP) endomembrane system organization 0.1511 Highly Informative Inherited
Biological Process (BP) divalent inorganic cation transport 0.002456 Highly Informative Inherited
Biological Process (BP) RNA splicing 0.3014 Highly Informative Inherited
Biological Process (BP) cellular carbohydrate catabolic process 0.0257 Highly Informative Inherited
Biological Process (BP) epithelial cell differentiation 1 Highly Informative Inherited
Biological Process (BP) regulation of blood pressure 0.0423 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 0.00214 Highly Informative Inherited
Biological Process (BP) regulation of epithelial cell proliferation 0.02179 Highly Informative Inherited
Biological Process (BP) cell proliferation 1 Highly Informative Inherited
Biological Process (BP) wound healing 0.1343 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 1 Highly Informative Inherited
Molecular Function (MF) binding 0.09314 Least Informative Inherited
Molecular Function (MF) hydrolase activity 0.918 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 0.0000738 Moderately Informative Direct
Molecular Function (MF) nucleic acid binding 1 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 1 Moderately Informative Inherited
Molecular Function (MF) molecular function regulator 0.3697 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 1 Moderately Informative Inherited
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 1 Moderately Informative Inherited
Molecular Function (MF) metal ion binding 0.00757 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) structural molecule activity 0.01724 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on glycosyl bonds 0 Informative Direct
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) signal transducer activity 0.000000000000007771 Informative Direct
Molecular Function (MF) sulfur compound binding 0.00000002071 Informative Direct
Molecular Function (MF) receptor binding 0.0001016 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 0.0007296 Informative Direct
Molecular Function (MF) transferase activity, transferring glycosyl groups 0.05063 Informative Inherited
Molecular Function (MF) transferase activity, transferring one-carbon groups 1 Informative Inherited
Molecular Function (MF) enzyme activator activity 0.3513 Informative Inherited
Molecular Function (MF) passive transmembrane transporter activity 0.00425 Informative Inherited
Molecular Function (MF) macromolecular complex binding 0.009405 Informative Inherited
Molecular Function (MF) peptidase regulator activity 0.004743 Informative Inherited
Molecular Function (MF) enzyme inhibitor activity 0.02479 Informative Inherited
Molecular Function (MF) phosphatase activity 0.1518 Informative Inherited
Molecular Function (MF) kinase activity 1 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 1 Informative Inherited
Molecular Function (MF) peptidase activity, acting on L-amino acid peptides 1 Informative Inherited
Molecular Function (MF) RNA binding 1 Informative Inherited
Molecular Function (MF) phospholipid binding 0.0366 Informative Inherited
Molecular Function (MF) hydrolase activity, hydrolyzing O-glycosyl compounds 0 Highly Informative Direct
Molecular Function (MF) monosaccharide binding 0.0001172 Highly Informative Direct
Molecular Function (MF) calcium ion binding 0 Highly Informative Direct
Molecular Function (MF) cell adhesion molecule binding 0 Highly Informative Direct
Molecular Function (MF) ubiquitin-like protein transferase activity 0 Highly Informative Direct
Molecular Function (MF) modified amino acid binding 0.00000000007948 Highly Informative Direct
Molecular Function (MF) heparin binding 0.0000000002425 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase regulator activity involved in apoptotic process 0.0000001382 Highly Informative Direct
Molecular Function (MF) gated channel activity 0.00002007 Highly Informative Direct
Molecular Function (MF) macromolecule transmembrane transporter activity 0.00002117 Highly Informative Direct
Molecular Function (MF) phosphoprotein phosphatase activity 0.0000253 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase inhibitor activity 0.0001139 Highly Informative Direct
Molecular Function (MF) ion channel activity 0.0006473 Highly Informative Direct
Molecular Function (MF) kinase regulator activity 0.0007291 Highly Informative Direct
Molecular Function (MF) S-adenosylmethionine-dependent methyltransferase activity 0.9868 Highly Informative Inherited
Molecular Function (MF) transferase activity, transferring hexosyl groups 0.1796 Highly Informative Inherited
Molecular Function (MF) amide transmembrane transporter activity 0.00458 Highly Informative Inherited
Molecular Function (MF) protein transporter activity 0.01149 Highly Informative Inherited
Molecular Function (MF) hormone binding 0.1191 Highly Informative Inherited
Molecular Function (MF) transmembrane signaling receptor activity 1 Highly Informative Inherited
Molecular Function (MF) protein kinase activity 1 Highly Informative Inherited
Molecular Function (MF) metallopeptidase activity 0.01016 Highly Informative Inherited
Cellular Component (CC) membrane 0.0004186 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) protein complex 0.568 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.5087 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) endomembrane system 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.0000005037 Moderately Informative Direct
Cellular Component (CC) cell projection 0.0006229 Moderately Informative Direct
Cellular Component (CC) intrinsic component of membrane 0.7897 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) transferase complex 1 Moderately Informative Inherited
Cellular Component (CC) bounding membrane of organelle 1 Moderately Informative Inherited
Cellular Component (CC) extracellular organelle 0.00001643 Informative Direct
Cellular Component (CC) endoplasmic reticulum membrane 0 Informative Direct
Cellular Component (CC) ribonucleoprotein granule 0.00000000000009741 Informative Direct
Cellular Component (CC) transporter complex 0.1833 Informative Inherited
Cellular Component (CC) supramolecular polymer 0.09951 Informative Inherited
Cellular Component (CC) plasma membrane region 0.3432 Informative Inherited
Cellular Component (CC) nucleoplasm part 0.8802 Informative Inherited
Cellular Component (CC) plasma membrane bounded cell projection part 1 Informative Inherited
Cellular Component (CC) neuron projection 0.3093 Informative Inherited
Cellular Component (CC) external encapsulating structure 0.00522 Informative Inherited
Cellular Component (CC) Golgi apparatus 0.06301 Informative Inherited
Cellular Component (CC) extracellular matrix component 0 Highly Informative Direct
Cellular Component (CC) sarcoplasm 0 Highly Informative Direct
Cellular Component (CC) tRNA-splicing ligase complex 0.000000000001317 Highly Informative Direct
Cellular Component (CC) P-body 0.00000002042 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 0.000003669 Highly Informative Direct
Cellular Component (CC) lamellipodium 0.00001462 Highly Informative Direct
Cellular Component (CC) nuclear body 0.2327 Highly Informative Inherited
Cellular Component (CC) presynapse 0.0874 Highly Informative Inherited
Cellular Component (CC) cell-cell junction 0.8862 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides1Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)1Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0.000000000002215Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an0.1378Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0.07915Moderately InformativeInherited
Enzyme Commission (EC)Metalloendopeptidases0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0.00000001837InformativeDirect
Enzyme Commission (EC)Cellulose 1,4-beta-cellobiosidase (non-reducing en0Highly InformativeDirect
Enzyme Commission (EC)Bontoxilysin0.000000000000213Highly InformativeDirect
Enzyme Commission (EC)Alpha-N-arabinofuranosidase0.0001267Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processUbl conjugation pathway0Moderately InformativeDirect
Biological processImmunity0Moderately InformativeDirect
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processHost-virus interaction0Moderately InformativeDirect
Biological processDifferentiation0Moderately InformativeDirect
Biological processApoptosis0.000000000001408Moderately InformativeDirect
Biological processVirulence0.00000000004158Moderately InformativeDirect
Biological processIon transport1Moderately InformativeInherited
Biological processVirus entry into host cell0InformativeDirect
Biological processNeurogenesis0InformativeDirect
Biological processAutophagy0InformativeDirect
Biological processAngiogenesis0InformativeDirect
Biological processPolysaccharide degradation0InformativeDirect
Biological processCell adhesion0InformativeDirect
Biological processCell wall biogenesis/degradation0.0000000000005717InformativeDirect
Biological processPlant defense0.000000000002555InformativeDirect
Biological processInnate immunity0.0000000008122InformativeDirect
Biological processHemostasis0.0001224InformativeDirect
Biological processAntiviral defense0Highly InformativeDirect
Biological processCalcium transport0.000000000000439Highly InformativeDirect
Biological processAcute phase0.000000000001293Highly InformativeDirect
Biological processUnfolded protein response0.00000000005943Highly InformativeDirect
Biological processBlood coagulation0.0001166Highly InformativeDirect
Biological processExocytosis0.0001411Highly InformativeDirect
Cellular componentMembrane0.000000000004567Least InformativeDirect
Cellular componentVirion0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentGolgi apparatus0.000002287Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.000006375Moderately InformativeDirect
Cellular componentExtracellular matrix0InformativeDirect
Cellular componentCapsid protein0InformativeDirect
Cellular componentVacuole0InformativeDirect
Cellular componentGPI-anchor0.000000000007648InformativeDirect
Cellular componentSarcoplasmic reticulum0Highly InformativeDirect
Cellular componentHost endoplasmic reticulum0Highly InformativeDirect
Cellular componentApoplast0Highly InformativeDirect
Cellular componentCell wall0Highly InformativeDirect
Coding sequence diversityAlternative splicing0.00004477Least InformativeDirect
Coding sequence diversityAlternative promoter usage0Moderately InformativeDirect
DiseaseDisease mutation0.00006618Least InformativeDirect
DiseaseDeafness0.0002729InformativeDirect
DiseaseDwarfism0.0006821InformativeDirect
DomainSignal0Least InformativeDirect
DomainRepeat0.00001824Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainCoiled coil0Moderately InformativeDirect
DomainZinc-finger0.000001208Moderately InformativeDirect
DomainEGF-like domain0InformativeDirect
DomainSignal-anchor0.00000587InformativeDirect
DomainLaminin EGF-like domain0Highly InformativeDirect
DomainCollagen0Highly InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionMetal-binding0.0002349Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionManganese0.000000006462Moderately InformativeDirect
Molecular functionLipid-binding0.7675Moderately InformativeInherited
Molecular functionLectin0InformativeDirect
Molecular functionSteroid-binding0.00001699Highly InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationProtease1Moderately InformativeInherited
Post-translational modificationKinase1Moderately InformativeInherited
Post-translational modificationGlycosidase0InformativeDirect
Post-translational modificationHeparin-binding0InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0.00000001952InformativeDirect
Post-translational modificationToxin0.00001012InformativeDirect
Post-translational modificationCalmodulin-binding0.00003679InformativeDirect
Post-translational modificationMetalloprotease0.0007835InformativeDirect
Post-translational modificationIon channel0.01974InformativeInherited
Post-translational modificationHemagglutinin0Highly InformativeDirect
Post-translational modificationCalcium channel0.0000000000004868Highly InformativeDirect
Post-translational modificationLigand-gated ion channel0.000000005276Highly InformativeDirect
Post-translational modificationMitogen0.00002563Highly InformativeDirect
Post-translational modificationNeurotoxin0.0007321Highly InformativeDirect
Post-translational modificationStorage protein0.002121Highly InformativeInherited
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationHydroxylation0InformativeDirect
Post-translational modificationProteoglycan0.0003746InformativeDirect
Post-translational modificationHeparan sulfate0.0000000009628Highly InformativeDirect
Post-translational modificationPeptidoglycan-anchor0.00001092Highly InformativeDirect
Post-translational modificationGamma-carboxyglutamic acid0.0002803Highly InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR008985 SSF49899 Protein matches
Abstract

Lectins and glucanases exhibit the common property of reversibly binding to specific complex carbohydrates. The lectins/glucanases are a diverse group of proteins found in a wide range of species from prokaryotes to humans. The different family members all contain a concanavalin A-like domain, which consists of a sandwich of 12-14 beta strands in two sheets with a complex topology. Members of this family are diverse, and include the lectins: legume lectins, cereal lectins, viral lectins, and animal lectins. Plant lectins function in the storage and transport of carbohydrates in seeds, the binding of nitrogen-fixing bacteria to root hairs, the inhibition of fungal growth or insect feeding, and in hormonally regulated plant growth [PubMed9094437]. Protein members include concanavalin A (Con A), favin, isolectin I, lectin IV, soybean agglutinin and lentil lectin. Animal lectins include the galectins, which are S-type lactose-binding and IgE-binding proteins such as S-lectin, CLC protein, galectin1, galectin2, galectin3 CRD, and Congerin I [PubMed11834744].

Other members with a Con A-like domain include the glucanases and xylanases. Bacterial and fungal beta-glucanases, such as Bacillus 1-3,1-4-beta-glucanse, carry out the acid catalysis of beta-glucans found in microorganisms and plants [PubMed7589539]. Similarly, kappa-Carrageenase degrades kappa-carrageenans from marine red algae cell walls [PubMed11435116]. Xylanase and cellobiohydrolase I degrade hemicellulose and cellulose, respectively [PubMed9618460, PubMed9466911].

There are many Con A-like domains found in proteins involved in cell recognition and adhesion. For example, several viral and bacterial toxins carry Con A-like domains. Examples include the Clostridium neurotoxins responsible for the neuroparalytic effects of botulism and tetanus [PubMed10932256]. The Pseudomonas exotoxin A, a virulence factor which is highly toxic to eukaryotic cells, causing the arrest of protein synthesis, contains a Con A-like domain involved in receptor binding [PubMed11734000]. Cholerae neuraminidase can bind to cell surfaces, possibly through their Con A-like domains, where they function as part of a mucinase complex to degrade the mucin layer of the gastrointestinal tract [PubMed7922030]. The rotaviral outer capsid protein, VP4, has a Con A-like sialic acid binding domain, which functions in cell attachment and membrane penetration [PubMed11867517].

Con A-like domains also play a role in cell recognition in eukaryotes. Proteins containing a Con A-like domain include the sex hormone-binding globulins which transport sex steroids in blood and regulate their access to target tissues [PubMed10675319], laminins which are large heterotrimeric glycoproteins involved in basement membrane architecture and function [