SUPERFAMILY 1.75 HMM library and genome assignments server

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Concanavalin A-like lectins/glucanases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Concanavalin A-like lectins/glucanases [ 49898]
Superfamily:   Concanavalin A-like lectins/glucanases [ 49899] (25)
Families:   Legume lectins [ 49900] (4)
  Lectin leg-like [ 74904] (3)
  Glycosyl hydrolases family 16 [ 49925] (5)
  Galectin (animal S-lectin) [ 49932] (8)
  Laminin G-like module [ 49944] (6)
  Thrombospondin C-terminal domain [ 101643]
  Pentraxin (pentaxin) [ 49951] (2)
  Calnexin/calreticulin [ 69236]
  vp4 sialic acid binding domain [ 74907]
  Hypothetical protein YesU [ 101646]
  Alginate lyase [ 101649] (3)
  Clostridium neurotoxins, the second last domain [ 49956] (2)
  Exotoxin A, N-terminal domain [ 49962]
  Vibrio cholerae sialidase, N-terminal and insertion domains [ 49965]
  Leech intramolecular trans-sialidase, N-terminal domain [ 49968]
  Trypanosoma sialidase, C-terminal domain [ 82038]
  Glycosyl hydrolase family 7 catalytic core [ 49971]
  Glycosyl hydrolases family 32 C-terminal domain [ 101652] (2)
  Xylanase/endoglucanase 11/12 [ 49978] (2)
  Peptidase A4 [ 101656] (2)
  Alpha-L-arabinofuranosidase B, N-terminal domain [ 110143]
  SPRY domain [ 141154] (5)
  Beta-D-xylosidase C-terminal domain-like [ 141161]
  SO2946-like [ 141167]
  MAM domain [ 141170]


Superfamily statistics
Genomes (2,188) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 64,020 113,303 236
Proteins 50,626 98,511 228


Functional annotation
General category Metabolism
Detailed category Secondary metabolism

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism cellular process0.000019860Least InformativeDirect
Biological Process (BP)cellular component organization or biogenesis0.00000000039440Least InformativeDirect
Biological Process (BP)developmental process0.0012480Least InformativeInherited
Biological Process (BP)regulation of cellular process0.45190.4326Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.0043750.7265Least InformativeInherited
Biological Process (BP)localization10.0000000000321Least InformativeInherited
Biological Process (BP)multicellular organismal process0.014150Least InformativeInherited
Biological Process (BP)carbohydrate metabolic process0.0000000000069680.0000008945Moderately InformativeDirect
Biological Process (BP)regulation of developmental process0.00060820.0000000001109Moderately InformativeDirect
Biological Process (BP)regulation of multicellular organismal process0.000037750Moderately InformativeDirect
Biological Process (BP)cellular localization0.78770.001336Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.88020.1165Moderately InformativeInherited
Biological Process (BP)cell differentiation0.001670Moderately InformativeInherited
Biological Process (BP)single-organism developmental process0.5410.000000000008591Moderately InformativeInherited
Biological Process (BP)regulation of localization0.062110.000001158Moderately InformativeInherited
Biological Process (BP)tissue development0.081270.02732Moderately InformativeInherited
Biological Process (BP)organ development0.53910.3238Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.13750.02372Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.79840.1602Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.10460.00000001004Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.35510.0000000007009Moderately InformativeInherited
Biological Process (BP)system process0.75260.000009689Moderately InformativeInherited
Biological Process (BP)nervous system development0.83680.00000001053Moderately InformativeInherited
Biological Process (BP)cellular component biogenesis11Moderately InformativeInherited
Biological Process (BP)polysaccharide metabolic process00.00000000000006699InformativeDirect
Biological Process (BP)carbohydrate catabolic process0.0000000000440.0000000841InformativeDirect
Biological Process (BP)biological adhesion0.00024420InformativeDirect
Biological Process (BP)cellular membrane organization0.42320.00000007262InformativeInherited
Biological Process (BP)synaptic transmission0.024820.000007081InformativeInherited
Biological Process (BP)regulation of secretion0.000080870.004831InformativeInherited
Biological Process (BP)regulation of establishment of protein localization0.20290.1542InformativeInherited
Biological Process (BP)muscle tissue development0.0016130.01173InformativeInherited
Biological Process (BP)muscle structure development0.0012650.0137InformativeInherited
Biological Process (BP)regulation of cell proliferation0.59340.001318InformativeInherited
Biological Process (BP)secretion by cell0.057640.000000134InformativeInherited
Biological Process (BP)cellular carbohydrate metabolic process0.0022720.2204InformativeInherited
Biological Process (BP)regulation of cellular component biogenesis0.023170.00000006333InformativeInherited
Biological Process (BP)regulation of nervous system development0.035230.02484InformativeInherited
Biological Process (BP)regulation of growth0.10830.000001256InformativeInherited
Biological Process (BP)regulation of cell development0.076110.00209InformativeInherited
Biological Process (BP)polysaccharide catabolic process0.0000000000022670.00000000000001772Highly InformativeDirect
Biological Process (BP)muscle organ development0.00017760.000003249Highly InformativeDirect
Biological Process (BP)signal release0.00021920.0000003712Highly InformativeDirect
Biological Process (BP)extracellular matrix organization0.000011840Highly InformativeDirect
Biological Process (BP)positive regulation of programmed cell death0.00059220.0004381Highly InformativeDirect
Biological Process (BP)cell wall macromolecule metabolic process00.00000000000003782Highly InformativeDirect
Biological Process (BP)muscle fiber development0.000044760.00002444Highly InformativeDirect
Biological Process (BP)regulation of mononuclear cell proliferation0.0047040.1016Highly InformativeInherited
Biological Process (BP)regulation of T cell activation0.00058651Highly InformativeInherited
Biological Process (BP)regulation of striated muscle tissue development10.00000000003728Highly InformativeInherited
Biological Process (BP)regulation of developmental growth0.0094260.00000000000005902Highly InformativeInherited
Molecular Function (MF)hydrolase activity0.0004860.2429Least InformativeInherited
Molecular Function (MF)binding0.095690.00000006039Least InformativeInherited
Molecular Function (MF)transferase activity0.781Least InformativeInherited
Molecular Function (MF)cation binding0.39210.08012Moderately InformativeInherited
Molecular Function (MF)hydrolase activity, acting on glycosyl bonds00InformativeDirect
Molecular Function (MF)carbohydrate derivative binding0.00053350InformativeDirect
Molecular Function (MF)transferase activity, transferring glycosyl groups0.0000028930.004877InformativeInherited
Molecular Function (MF)calcium ion binding0.00040370Highly InformativeDirect
Molecular Function (MF)channel regulator activity0.00053790Highly InformativeDirect
Molecular Function (MF)transferase activity, transferring hexosyl groups0.000000074840.1502Highly InformativeInherited
Cellular Component (CC)extracellular region part0.014950Moderately InformativeInherited
Cellular Component (CC)cell surface0.00047930.000008569InformativeDirect
Cellular Component (CC)external encapsulating structure0.0000016820.000829InformativeDirect
Cellular Component (CC)extracellular matrix0.00000000000017070InformativeDirect
Cellular Component (CC)proteinaceous extracellular matrix0.0000000029040Highly InformativeDirect
Cellular Component (CC)extracellular matrix part0.0000000033730Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0.00000004617 Least Informative Direct
Biological Process (BP) localization 0.0000000000321 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.4326 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.7265 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.144 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) immune system process 0.000000000000003741 Moderately Informative Direct
Biological Process (BP) system process 0.000009689 Moderately Informative Direct
Biological Process (BP) carbohydrate metabolic process 0.0000008945 Moderately Informative Direct
Biological Process (BP) nervous system development 0.00000001053 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.000001451 Moderately Informative Direct
Biological Process (BP) cell differentiation 0 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.000001158 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 0.0004478 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 0.000000000008591 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 0.00000001149 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.0000000001109 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.00000001004 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.0002 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.0000000007009 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.02372 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.1602 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.1165 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.001336 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.9434 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.06237 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.02732 Moderately Informative Inherited
Biological Process (BP) organ development 0.3238 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.0000000009979 Informative Direct
Biological Process (BP) polysaccharide metabolic process 0.00000000000006699 Informative Direct
Biological Process (BP) cellular component movement 0 Informative Direct
Biological Process (BP) defense response 0.00000001057 Informative Direct
Biological Process (BP) immune response 0.00000003392 Informative Direct
Biological Process (BP) synaptic transmission 0.000007081 Informative Direct
Biological Process (BP) organ morphogenesis 0.0000007666 Informative Direct
Biological Process (BP) positive regulation of signal transduction 0.00000000005776 Informative Direct
Biological Process (BP) cellular membrane organization 0.00000007262 Informative Direct
Biological Process (BP) carbohydrate catabolic process 0.0000000841 Informative Direct
Biological Process (BP) biological adhesion 0 Informative Direct
Biological Process (BP) cell projection organization 0 Informative Direct
Biological Process (BP) regulation of defense response 0.0000000002666 Informative Direct
Biological Process (BP) secretion by cell 0.000000134 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.0000000000003072 Informative Direct
Biological Process (BP) regulation of growth 0.000001256 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) regulation of locomotion 0.00000000395 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.00000006333 Informative Direct
Biological Process (BP) generation of neurons 0.000001372 Informative Direct
Biological Process (BP) negative regulation of developmental process 0.000000000000007318 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0.0000000006692 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.0002531 Informative Direct
Biological Process (BP) localization of cell 0.000000000000003741 Informative Direct
Biological Process (BP) cellular chemical homeostasis 0.0009864 Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 0.0003529 Informative Direct
Biological Process (BP) protein modification by small protein conjugation or removal 0.00003128 Informative Direct
Biological Process (BP) cardiovascular system development 0.0009752 Informative Direct
Biological Process (BP) regulation of system process 0.3565 Informative Inherited
Biological Process (BP) negative regulation of cell death 1 Informative Inherited
Biological Process (BP) protein transport 0.3415 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) response to organonitrogen compound 0.3277 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.6111 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.15 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.06143 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.2723 Informative Inherited
Biological Process (BP) response to nutrient levels 0.3645 Informative Inherited
Biological Process (BP) metal ion transport 0.16 Informative Inherited
Biological Process (BP) transmembrane transport 1 Informative Inherited
Biological Process (BP) protein oligomerization 0.001015 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.5267 Informative Inherited
Biological Process (BP) gland development 0.815 Informative Inherited
Biological Process (BP) tube development 0.8117 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.02176 Informative Inherited
Biological Process (BP) sensory organ development 0.02384 Informative Inherited
Biological Process (BP) regulation of peptidase activity 0.001057 Informative Inherited
Biological Process (BP) chromosome organization 1 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.007683 Informative Inherited
Biological Process (BP) regulation of cell development 0.00209 Informative Inherited
Biological Process (BP) negative regulation of transport 0.004646 Informative Inherited
Biological Process (BP) regulation of secretion 0.004831 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.02484 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 1 Informative Inherited
Biological Process (BP) muscle structure development 0.0137 Informative Inherited
Biological Process (BP) growth 0.007548 Informative Inherited
Biological Process (BP) embryonic organ development 0.3345 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.6516 Informative Inherited
Biological Process (BP) single-organism behavior 0.2145 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.7911 Informative Inherited
Biological Process (BP) positive regulation of transport 0.5652 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.1478 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 0.2204 Informative Inherited
Biological Process (BP) pigment metabolic process 0.3072 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.001318 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.07044 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.2319 Informative Inherited
Biological Process (BP) apoptotic process 0.2743 Informative Inherited
Biological Process (BP) response to other organism 0.01193 Informative Inherited
Biological Process (BP) response to cytokine stimulus 0.5597 Informative Inherited
Biological Process (BP) dephosphorylation 0.088 Informative Inherited
Biological Process (BP) regulation of apoptotic process 1 Informative Inherited
Biological Process (BP) regulation of establishment of protein localization 0.1542 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 1 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 1 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.01446 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.4903 Informative Inherited
Biological Process (BP) positive regulation of protein modification process 0.1999 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.2295 Informative Inherited
Biological Process (BP) response to inorganic substance 1 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 1 Informative Inherited
Biological Process (BP) central nervous system development 1 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 1 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.3295 Informative Inherited
Biological Process (BP) phosphorylation 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.7876 Informative Inherited
Biological Process (BP) muscle system process 0.08674 Informative Inherited
Biological Process (BP) cation homeostasis 0.2899 Informative Inherited
Biological Process (BP) cytoplasmic transport 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.2329 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.02464 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.01688 Informative Inherited
Biological Process (BP) RNA processing 1 Informative Inherited
Biological Process (BP) ncRNA metabolic process 1 Informative Inherited
Biological Process (BP) muscle tissue development 0.01173 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.04891 Informative Inherited
Biological Process (BP) blood circulation 1 Informative Inherited
Biological Process (BP) leukocyte activation 1 Informative Inherited
Biological Process (BP) immune effector process 1 Informative Inherited
Biological Process (BP) regulation of immune response 0.005734 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.2578 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.8985 Informative Inherited
Biological Process (BP) response to wounding 0.001295 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) polysaccharide catabolic process 0.00000000000001772 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 0.0000000007218 Highly Informative Direct
Biological Process (BP) skeletal system development 0.0001973 Highly Informative Direct
Biological Process (BP) regulation of neurotransmitter levels 0.000000000008624 Highly Informative Direct
Biological Process (BP) protein dephosphorylation 0.00005483 Highly Informative Direct
Biological Process (BP) calcium ion transport 0.00003847 Highly Informative Direct
Biological Process (BP) neurotransmitter transport 0 Highly Informative Direct
Biological Process (BP) cellular calcium ion homeostasis 0.0009713 Highly Informative Direct
Biological Process (BP) phagocytosis 0 Highly Informative Direct
Biological Process (BP) chemotaxis 0 Highly Informative Direct
Biological Process (BP) cell adhesion 0 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 0.00000000001765 Highly Informative Direct
Biological Process (BP) muscle organ development 0.000003249 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 0.0001143 Highly Informative Direct
Biological Process (BP) regulation of cell size 0.00003307 Highly Informative Direct
Biological Process (BP) response to purine-containing compound 0.00005625 Highly Informative Direct
Biological Process (BP) regulation of striated muscle tissue development 0.00000000003728 Highly Informative Direct
Biological Process (BP) protein ubiquitination 0.00000000002032 Highly Informative Direct
Biological Process (BP) peptidyl-serine modification 0.00007959 Highly Informative Direct
Biological Process (BP) pentose metabolic process 0.000002589 Highly Informative Direct
Biological Process (BP) telencephalon development 0.0006066 Highly Informative Direct
Biological Process (BP) signal release 0.0000003712 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0 Highly Informative Direct
Biological Process (BP) negative regulation of cell growth 0.000001159 Highly Informative Direct
Biological Process (BP) neuron projection development 0.00003368 Highly Informative Direct
Biological Process (BP) positive regulation of defense response 0.000001237 Highly Informative Direct
Biological Process (BP) cell part morphogenesis 0.00000000002897 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 0.0002697 Highly Informative Direct
Biological Process (BP) negative regulation of locomotion 0.000000000002275 Highly Informative Direct
Biological Process (BP) response to drug 0.000001283 Highly Informative Direct
Biological Process (BP) defense response to bacterium 0.000003054 Highly Informative Direct
Biological Process (BP) positive regulation of programmed cell death 0.0004381 Highly Informative Direct
Biological Process (BP) response to alkaloid 0.00002674 Highly Informative Direct
Biological Process (BP) regulation of multi-organism process 0 Highly Informative Direct
Biological Process (BP) cell wall macromolecule metabolic process 0.00000000000003782 Highly Informative Direct
Biological Process (BP) multicellular organismal metabolic process 0.000005265 Highly Informative Direct
Biological Process (BP) cellular carbohydrate catabolic process 0.0008564 Highly Informative Direct
Biological Process (BP) regulation of innate immune response 0.000000000001428 Highly Informative Direct
Biological Process (BP) regulation of angiogenesis 0.000005353 Highly Informative Direct
Biological Process (BP) developmental growth 0.000181 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 0.00000000000005902 Highly Informative Direct
Biological Process (BP) muscle fiber development 0.00002444 Highly Informative Direct
Biological Process (BP) regulation of cytokine secretion 0.0000001316 Highly Informative Direct
Biological Process (BP) positive regulation of peptidyl-tyrosine phosphorylation 0.000004947 Highly Informative Direct
Biological Process (BP) regulation of synaptic transmission 0.0001107 Highly Informative Direct
Biological Process (BP) negative regulation of secretion 0.0001813 Highly Informative Direct
Biological Process (BP) positive regulation of sequence-specific DNA binding transcription factor activity 0 Highly Informative Direct
Biological Process (BP) negative regulation of cellular component movement 0.0003649 Highly Informative Direct
Biological Process (BP) connective tissue development 0.000001114 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.09833 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 0.9942 Highly Informative Inherited
Biological Process (BP) negative regulation of apoptotic process 1 Highly Informative Inherited
Biological Process (BP) response to carbohydrate stimulus 0.00589 Highly Informative Inherited
Biological Process (BP) carbohydrate homeostasis 0.01285 Highly Informative Inherited
Biological Process (BP) developmental maturation 0.7831 Highly Informative Inherited
Biological Process (BP) vesicle organization 0.02203 Highly Informative Inherited
Biological Process (BP) positive regulation of protein kinase activity 0.04205 Highly Informative Inherited
Biological Process (BP) mammary gland epithelium development 0.006278 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 0.01965 Highly Informative Inherited
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 0.02214 Highly Informative Inherited
Biological Process (BP) protein methylation 0.05374 Highly Informative Inherited
Biological Process (BP) histone modification 1 Highly Informative Inherited
Biological Process (BP) regulation of ion homeostasis 0.01091 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.1582 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0.6122 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.005098 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.01556 Highly Informative Inherited
Biological Process (BP) regulation of behavior 0.02336 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 0.2342 Highly Informative Inherited
Biological Process (BP) leukocyte migration 0.7357 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.7387 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.04717 Highly Informative Inherited
Biological Process (BP) negative regulation of cell activation 0.1041 Highly Informative Inherited
Biological Process (BP) regulation of mononuclear cell proliferation 0.1016 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 1 Highly Informative Inherited
Biological Process (BP) regulation of endocytosis 0.001034 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 0.5357 Highly Informative Inherited
Biological Process (BP) positive regulation of cell activation 0.005473 Highly Informative Inherited
Biological Process (BP) ossification 0.009396 Highly Informative Inherited
Biological Process (BP) regulation of neuron apoptotic process 0.1595 Highly Informative Inherited
Biological Process (BP) negative regulation of endopeptidase activity 0.01843 Highly Informative Inherited
Biological Process (BP) regulation of cysteine-type endopeptidase activity involved in apoptotic process 0.007746 Highly Informative Inherited
Biological Process (BP) myeloid cell development 0.3742 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.6334 Highly Informative Inherited
Biological Process (BP) negative regulation of protein transport 0.002727 Highly Informative Inherited
Biological Process (BP) regulation of intracellular protein transport 0.8779 Highly Informative Inherited
Biological Process (BP) regulation of nucleocytoplasmic transport 0.3332 Highly Informative Inherited
Biological Process (BP) regulation of protein localization to nucleus 0.2915 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular transport 0.007581 Highly Informative Inherited
Biological Process (BP) glycosaminoglycan metabolic process 0.6053 Highly Informative Inherited
Biological Process (BP) membrane fusion 1 Highly Informative Inherited
Biological Process (BP) multi-organism cellular process 0.2225 Highly Informative Inherited
Biological Process (BP) protein phosphorylation 1 Highly Informative Inherited
Biological Process (BP) pigment biosynthetic process 0.2661 Highly Informative Inherited
Biological Process (BP) mesenchyme development 0.009183 Highly Informative Inherited
Biological Process (BP) stem cell development 1 Highly Informative Inherited
Biological Process (BP) regulation of cell adhesion 0.0748 Highly Informative Inherited
Biological Process (BP) oligosaccharide metabolic process 0.1194 Highly Informative Inherited
Biological Process (BP) Golgi vesicle transport 0.0974 Highly Informative Inherited
Biological Process (BP) retina development in camera-type eye 0.00611 Highly Informative Inherited
Biological Process (BP) cardiac muscle tissue development 0.07999 Highly Informative Inherited
Biological Process (BP) heart morphogenesis 0.1883 Highly Informative Inherited
Biological Process (BP) regulation of blood pressure 0.2174 Highly Informative Inherited
Biological Process (BP) B cell activation 0.3202 Highly Informative Inherited
Biological Process (BP) leukocyte activation involved in immune response 0.1153 Highly Informative Inherited
Biological Process (BP) immune response-activating signal transduction 0.001124 Highly Informative Inherited
Biological Process (BP) wound healing 0.1895 Highly Informative Inherited
Biological Process (BP) RNA splicing 0.1812 Highly Informative Inherited
Molecular Function (MF) binding 0.00000006039 Least Informative Direct
Molecular Function (MF) hydrolase activity 0.2429 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) structural molecule activity 0.0002693 Moderately Informative Direct
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) enzyme regulator activity 1 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 1 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 1 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 1 Moderately Informative Inherited
Molecular Function (MF) cation binding 0.08012 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) receptor activity 0 Informative Direct
Molecular Function (MF) receptor binding 0.0000007238 Informative Direct
Molecular Function (MF) hydrolase activity, acting on glycosyl bonds 0 Informative Direct
Molecular Function (MF) ligase activity, forming carbon-nitrogen bonds 0.00000000000002183 Informative Direct
Molecular Function (MF) carboxylic acid binding 0.0000001251 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 0.00008689 Informative Direct
Molecular Function (MF) molecular transducer activity 0.0000000113 Informative Direct
Molecular Function (MF) peptidase regulator activity 0.0008474 Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0 Informative Direct
Molecular Function (MF) sulfur compound binding 0.000000002285 Informative Direct
Molecular Function (MF) inorganic cation transmembrane transporter activity 0.01189 Informative Inherited
Molecular Function (MF) enzyme inhibitor activity 0.00774 Informative Inherited
Molecular Function (MF) nucleoside-triphosphatase activity 1 Informative Inherited
Molecular Function (MF) enzyme activator activity 0.2846 Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 0.004877 Informative Inherited
Molecular Function (MF) RNA binding 1 Informative Inherited
Molecular Function (MF) kinase activity 1 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 1 Informative Inherited
Molecular Function (MF) phosphoric ester hydrolase activity 0.4955 Informative Inherited
Molecular Function (MF) lipid binding 0.006463 Informative Inherited
Molecular Function (MF) phosphoprotein phosphatase activity 0.00003679 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase inhibitor activity 0.0001794 Highly Informative Direct
Molecular Function (MF) cation channel activity 0.000001507 Highly Informative Direct
Molecular Function (MF) calcium ion binding 0 Highly Informative Direct
Molecular Function (MF) heparin binding 0.00000000003909 Highly Informative Direct
Molecular Function (MF) calcium ion transmembrane transporter activity 0.0000000000008119 Highly Informative Direct
Molecular Function (MF) channel regulator activity 0 Highly Informative Direct
Molecular Function (MF) small conjugating protein ligase activity 0 Highly Informative Direct
Molecular Function (MF) protein kinase regulator activity 0.000335 Highly Informative Direct
Molecular Function (MF) ion gated channel activity 0.000003768 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase regulator activity involved in apoptotic process 0.00000002225 Highly Informative Direct
Molecular Function (MF) amino acid binding 0.006287 Highly Informative Inherited
Molecular Function (MF) transferase activity, transferring hexosyl groups 0.1502 Highly Informative Inherited
Molecular Function (MF) protein complex binding 0.004087 Highly Informative Inherited
Molecular Function (MF) protein kinase activity 1 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) membrane 0.04263 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.00001486 Moderately Informative Direct
Cellular Component (CC) endomembrane system 0.00055 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 0.0002509 Moderately Informative Direct
Cellular Component (CC) vesicle 0.00001528 Moderately Informative Direct
Cellular Component (CC) cell projection 0.00000234 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) ribonucleoprotein complex 0.003043 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.8758 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum membrane 0.000001087 Informative Direct
Cellular Component (CC) cell surface 0.000008569 Informative Direct
Cellular Component (CC) cell junction 0.0005318 Informative Direct
Cellular Component (CC) external encapsulating structure 0.000829 Informative Direct
Cellular Component (CC) extracellular matrix 0 Informative Direct
Cellular Component (CC) cell leading edge 0.00001626 Informative Direct
Cellular Component (CC) synapse part 0.0000008126 Informative Direct
Cellular Component (CC) extracellular membrane-bounded organelle 0.000001137 Informative Direct
Cellular Component (CC) nucleoplasm part 1 Informative Inherited
Cellular Component (CC) coated vesicle 1 Informative Inherited
Cellular Component (CC) Golgi apparatus 0.01924 Informative Inherited
Cellular Component (CC) cytoplasmic mRNA processing body 0 Highly Informative Direct
Cellular Component (CC) proteinaceous extracellular matrix 0 Highly Informative Direct
Cellular Component (CC) adherens junction 0.000001684 Highly Informative Direct
Cellular Component (CC) sarcoplasmic reticulum 0.000000000004043 Highly Informative Direct
Cellular Component (CC) sarcolemma 0.0006948 Highly Informative Direct
Cellular Component (CC) extracellular matrix part 0 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 0.00000005814 Highly Informative Direct
Cellular Component (CC) cell projection membrane 0.02481 Highly Informative Inherited
Cellular Component (CC) nuclear body 0.008998 Highly Informative Inherited
Cellular Component (CC) transport vesicle 0.0615 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides1Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)1Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0.000000000002215Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an0.1378Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0.07915Moderately InformativeInherited
Enzyme Commission (EC)Metalloendopeptidases0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0.00000001837InformativeDirect
Enzyme Commission (EC)Cellulose 1,4-beta-cellobiosidase (non-reducing en0Highly InformativeDirect
Enzyme Commission (EC)Bontoxilysin0.000000000000213Highly InformativeDirect
Enzyme Commission (EC)Alpha-N-arabinofuranosidase0.0001267Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.5229Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.3892Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the globe0.7334Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the fundus0.1586InformativeInherited
Phenotypic Abnormality (PA)Abnormality of long bone morphology0.2056InformativeInherited
Phenotypic Abnormality (PA)Vitreoretinal degeneration0.0001496Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the epiphyses0.03385Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the femur0.04227Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.03321Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.9253Least InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development0.2743Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.758Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal voluntary movement0.825InformativeInherited
Mammalian Phenotype (MP)abnormal basement membrane morphology0.0002394Highly InformativeDirect
Mammalian Phenotype (MP)abnormal glutamate-mediated receptor currents0.05702Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)neuron development variant0.00004145InformativeDirect
Worm Phenotype (WP)muscle cell morphology variant0.004958InformativeInherited
Worm Phenotype (WP)axon guidance variant0.000004281Highly InformativeDirect
Worm Phenotype (WP)axon morphology variant0.000005115Highly InformativeDirect
Worm Phenotype (WP)myopodia present0.0004903Highly InformativeDirect
Worm Phenotype (WP)muscle arm development defective0.0006307Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)cell polarity defective0.0001416InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

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