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Concanavalin A-like lectins/glucanases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Concanavalin A-like lectins/glucanases [ 49898]
Superfamily:   Concanavalin A-like lectins/glucanases [ 49899] (25)
Families:   Legume lectins [ 49900] (4)
  Lectin leg-like [ 74904] (3)
  Glycosyl hydrolases family 16 [ 49925] (5)
  Galectin (animal S-lectin) [ 49932] (8)
  Laminin G-like module [ 49944] (6)
  Thrombospondin C-terminal domain [ 101643]
  Pentraxin (pentaxin) [ 49951] (2)
  Calnexin/calreticulin [ 69236]
  vp4 sialic acid binding domain [ 74907]
  Hypothetical protein YesU [ 101646]
  Alginate lyase [ 101649] (3)
  Clostridium neurotoxins, the second last domain [ 49956] (2)
  Exotoxin A, N-terminal domain [ 49962]
  Vibrio cholerae sialidase, N-terminal and insertion domains [ 49965]
  Leech intramolecular trans-sialidase, N-terminal domain [ 49968]
  Trypanosoma sialidase, C-terminal domain [ 82038]
  Glycosyl hydrolase family 7 catalytic core [ 49971]
  Glycosyl hydrolases family 32 C-terminal domain [ 101652] (2)
  Xylanase/endoglucanase 11/12 [ 49978] (2)
  Peptidase A4 [ 101656] (2)
  Alpha-L-arabinofuranosidase B, N-terminal domain [ 110143]
  SPRY domain [ 141154] (5)
  Beta-D-xylosidase C-terminal domain-like [ 141161]
  SO2946-like [ 141167]
  MAM domain [ 141170]


Superfamily statistics
Genomes (2,194) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 64,304 113,303 236
Proteins 50,814 98,511 228


Functional annotation
General category Metabolism
Detailed category Secondary metabolism

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biological regulation0.86730.0001535Least InformativeInherited
Biological Process (BP)primary metabolic process11Least InformativeInherited
Biological Process (BP)macromolecule metabolic process0.1650.704Least InformativeInherited
Biological Process (BP)carbohydrate metabolic process0.00000000610.000009491Moderately InformativeDirect
Biological Process (BP)regulation of multicellular organismal process0.000053020.00000000002277Moderately InformativeDirect
Biological Process (BP)regulation of localization0.075530.0001049Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.050621Moderately InformativeInherited
Biological Process (BP)system development0.0077330.000000000003942Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.0820.00000000001724Moderately InformativeInherited
Biological Process (BP)polysaccharide metabolic process00.00000000005103InformativeDirect
Biological Process (BP)carbohydrate catabolic process0.000000010220.000001971InformativeDirect
Biological Process (BP)cell wall organization or biogenesis00InformativeDirect
Biological Process (BP)regulation of secretion0.00071940.005078InformativeInherited
Biological Process (BP)regulation of cytokine production0.0013510.004152InformativeInherited
Biological Process (BP)regulation of establishment of protein localization0.0020521InformativeInherited
Biological Process (BP)regulation of peptide transport0.0036080.2711InformativeInherited
Biological Process (BP)regulation of cell proliferation0.38470.02339InformativeInherited
Biological Process (BP)circulatory system development0.069330.001801InformativeInherited
Biological Process (BP)anatomical structure formation involved in morphogenesis0.0016920.008763InformativeInherited
Biological Process (BP)polysaccharide catabolic process0.0000000022730.000000001182Highly InformativeDirect
Biological Process (BP)angiogenesis0.000081580.000000392Highly InformativeDirect
Biological Process (BP)cell wall macromolecule metabolic process00Highly InformativeDirect
Biological Process (BP)regulation of cytokine secretion0.00033450.000000001302Highly InformativeDirect
Biological Process (BP)regulation of lymphocyte proliferation0.43521Highly InformativeInherited
Biological Process (BP)regulation of T cell activation0.00081741Highly InformativeInherited
Molecular Function (MF)hydrolase activity0.023640.8272Least InformativeInherited
Molecular Function (MF)binding0.32220.03165Least InformativeInherited
Molecular Function (MF)transferase activity11Least InformativeInherited
Molecular Function (MF)small molecule binding0.43241Moderately InformativeInherited
Molecular Function (MF)carbohydrate derivative binding0.018670.00002395Moderately InformativeInherited
Molecular Function (MF)hydrolase activity, acting on glycosyl bonds00InformativeDirect
Molecular Function (MF)transferase activity, transferring glycosyl groups0.035840.03418InformativeInherited
Molecular Function (MF)hydrolase activity, hydrolyzing O-glycosyl compounds00Highly InformativeDirect
Molecular Function (MF)monosaccharide binding0.00057780.0009578Highly InformativeDirect
Molecular Function (MF)transferase activity, transferring hexosyl groups0.0060340.1642Highly InformativeInherited
Cellular Component (CC)extracellular region part0.62620Moderately InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0.000003299 Least Informative Direct
Biological Process (BP) biological regulation 0.0001535 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.0511 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 0.704 Least Informative Inherited
Biological Process (BP) immune system process 0.00000000000001615 Moderately Informative Direct
Biological Process (BP) carbohydrate metabolic process 0.000009491 Moderately Informative Direct
Biological Process (BP) cell communication 0.0004373 Moderately Informative Direct
Biological Process (BP) response to external stimulus 0 Moderately Informative Direct
Biological Process (BP) response to biotic stimulus 0.000003994 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.00000000001724 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 0.0000000000000109 Moderately Informative Direct
Biological Process (BP) regulation of signaling 0.00000000000004133 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.0001049 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0.000000004958 Moderately Informative Direct
Biological Process (BP) system development 0.000000000003942 Moderately Informative Direct
Biological Process (BP) cellular developmental process 0 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.0000001435 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.00000000002277 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.0004299 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) single organism signaling 0.004114 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.006509 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) nitrogen compound transport 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.009867 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.2936 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.04647 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.3138 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.001098 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.1633 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.9509 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.02228 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.02508 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) polysaccharide metabolic process 0.00000000005103 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0 Informative Direct
Biological Process (BP) immune response 0.00000008219 Informative Direct
Biological Process (BP) cell-cell signaling 0.0000000006682 Informative Direct
Biological Process (BP) positive regulation of signal transduction 0.000000000005034 Informative Direct
Biological Process (BP) carbohydrate catabolic process 0.000001971 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.00000000003052 Informative Direct
Biological Process (BP) regulation of defense response 0.0000000000006941 Informative Direct
Biological Process (BP) regulation of protein modification process 0.0001338 Informative Direct
Biological Process (BP) positive regulation of cellular protein metabolic process 0.00001583 Informative Direct
Biological Process (BP) cellular component morphogenesis 0 Informative Direct
Biological Process (BP) response to cytokine 0.0001086 Informative Direct
Biological Process (BP) regulation of growth 0.00005872 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) regulation of locomotion 0.0000006094 Informative Direct
Biological Process (BP) positive regulation of phosphate metabolic process 0.000005797 Informative Direct
Biological Process (BP) cell development 0.0000000002753 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0.00000001624 Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.0000000000001311 Informative Direct
Biological Process (BP) cell wall organization or biogenesis 0 Informative Direct
Biological Process (BP) defense response to other organism 0.000001081 Informative Direct
Biological Process (BP) negative regulation of protein metabolic process 0.1678 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.4236 Informative Inherited
Biological Process (BP) ion homeostasis 1 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.001264 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.3346 Informative Inherited
Biological Process (BP) regulation of apoptotic process 1 Informative Inherited
Biological Process (BP) growth 0.4052 Informative Inherited
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) organelle assembly 1 Informative Inherited
Biological Process (BP) intracellular protein transport 1 Informative Inherited
Biological Process (BP) single-organism intracellular transport 0.6654 Informative Inherited
Biological Process (BP) behavior 0.3092 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.2592 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.3303 Informative Inherited
Biological Process (BP) cellular response to inorganic substance 0.09437 Informative Inherited
Biological Process (BP) transmembrane transport 1 Informative Inherited
Biological Process (BP) metal ion transport 0.5097 Informative Inherited
Biological Process (BP) regulation of transferase activity 0.7836 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 1 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.01046 Informative Inherited
Biological Process (BP) sensory organ development 0.2045 Informative Inherited
Biological Process (BP) regulation of proteolysis 0.1033 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.00449 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 0.1436 Informative Inherited
Biological Process (BP) response to bacterium 0.2004 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.2102 Informative Inherited
Biological Process (BP) regulation of cell differentiation 0.00958 Informative Inherited
Biological Process (BP) generation of neurons 0.1791 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.08978 Informative Inherited
Biological Process (BP) regulation of secretion 0.005078 Informative Inherited
Biological Process (BP) negative regulation of transport 0.002335 Informative Inherited
Biological Process (BP) regulation of establishment of protein localization 1 Informative Inherited
Biological Process (BP) regulation of peptide transport 0.2711 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 0.2094 Informative Inherited
Biological Process (BP) pigment metabolic process 0.1525 Informative Inherited
Biological Process (BP) positive regulation of transport 0.7828 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) membrane organization 0.2146 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) negative regulation of molecular function 1 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 1 Informative Inherited
Biological Process (BP) response to nitrogen compound 1 Informative Inherited
Biological Process (BP) negative regulation of cell death 1 Informative Inherited
Biological Process (BP) regulation of cellular localization 0.6185 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.004152 Informative Inherited
Biological Process (BP) response to extracellular stimulus 1 Informative Inherited
Biological Process (BP) chromosome organization 1 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 1 Informative Inherited
Biological Process (BP) response to metal ion 0.8064 Informative Inherited
Biological Process (BP) embryo development 1 Informative Inherited
Biological Process (BP) regulation of transcription, DNA-templated 1 Informative Inherited
Biological Process (BP) supramolecular fiber organization 0.4329 Informative Inherited
Biological Process (BP) central nervous system development 1 Informative Inherited
Biological Process (BP) monosaccharide metabolic process 0.267 Informative Inherited
Biological Process (BP) interspecies interaction between organisms 1 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.3344 Informative Inherited
Biological Process (BP) phosphorylation 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.3583 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.008763 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.01243 Informative Inherited
Biological Process (BP) regulation of ion transport 0.4487 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.1823 Informative Inherited
Biological Process (BP) system process 0.3322 Informative Inherited
Biological Process (BP) secretion by cell 0.03957 Informative Inherited
Biological Process (BP) dephosphorylation 0.004202 Informative Inherited
Biological Process (BP) tRNA metabolic process 0.7373 Informative Inherited
Biological Process (BP) ncRNA processing 1 Informative Inherited
Biological Process (BP) positive regulation of immune response 0.01471 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.02339 Informative Inherited
Biological Process (BP) regulation of phosphorylation 0.01522 Informative Inherited
Biological Process (BP) tissue development 1 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 0.005433 Informative Inherited
Biological Process (BP) circulatory system development 0.001801 Informative Inherited
Biological Process (BP) polysaccharide catabolic process 0.000000001182 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 0.000000000000003764 Highly Informative Direct
Biological Process (BP) regulation of neurotransmitter levels 0.0002651 Highly Informative Direct
Biological Process (BP) angiogenesis 0.000000392 Highly Informative Direct
Biological Process (BP) activation of innate immune response 0.000000002227 Highly Informative Direct
Biological Process (BP) muscle system process 0.0003166 Highly Informative Direct
Biological Process (BP) protein dephosphorylation 0.0005837 Highly Informative Direct
Biological Process (BP) phagocytosis 0.000000000000003764 Highly Informative Direct
Biological Process (BP) chemotaxis 0 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 0 Highly Informative Direct
Biological Process (BP) gastrulation 0.0002715 Highly Informative Direct
Biological Process (BP) regulation of cell size 0.000374 Highly Informative Direct
Biological Process (BP) oligosaccharide catabolic process 0.0004295 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.00007102 Highly Informative Direct
Biological Process (BP) biological adhesion 0 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0 Highly Informative Direct
Biological Process (BP) positive regulation of intracellular transport 0.0007546 Highly Informative Direct
Biological Process (BP) protein modification by small protein conjugation 0.00000362 Highly Informative Direct
Biological Process (BP) regulation of interleukin-1 production 0.000002412 Highly Informative Direct
Biological Process (BP) negative regulation of locomotion 0.000000000006555 Highly Informative Direct
Biological Process (BP) response to drug 0.000000001747 Highly Informative Direct
Biological Process (BP) positive regulation of MAPK cascade 0.0000574 Highly Informative Direct
Biological Process (BP) negative regulation of multi-organism process 0.0000003408 Highly Informative Direct
Biological Process (BP) cell wall macromolecule metabolic process 0 Highly Informative Direct
Biological Process (BP) negative regulation of growth 0.00000154 Highly Informative Direct
Biological Process (BP) regulation of fibroblast proliferation 0.0001431 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 0.00006518 Highly Informative Direct
Biological Process (BP) neuron development 0 Highly Informative Direct
Biological Process (BP) regulation of cytokine secretion 0.000000001302 Highly Informative Direct
Biological Process (BP) regulation of viral process 0.000000000000003764 Highly Informative Direct
Biological Process (BP) regulation of sequence-specific DNA binding transcription factor activity 0 Highly Informative Direct
Biological Process (BP) negative regulation of cellular component movement 0.000001412 Highly Informative Direct
Biological Process (BP) negative regulation of nervous system development 0.0001802 Highly Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 0.0001753 Highly Informative Direct
Biological Process (BP) cellular response to calcium ion 0.00002754 Highly Informative Direct
Biological Process (BP) protein localization to membrane 0.0002447 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.0000005845 Highly Informative Direct
Biological Process (BP) trans-synaptic signaling 0 Highly Informative Direct
Biological Process (BP) negative regulation of secretion by cell 0.0000001934 Highly Informative Direct
Biological Process (BP) negative regulation of establishment of protein localization 0.0004322 Highly Informative Direct
Biological Process (BP) regulation of ion homeostasis 0.000528 Highly Informative Direct
Biological Process (BP) negative regulation of endopeptidase activity 0.008925 Highly Informative Inherited
Biological Process (BP) inorganic cation transmembrane transport 0.01588 Highly Informative Inherited
Biological Process (BP) cellular calcium ion homeostasis 0.009689 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.03642 Highly Informative Inherited
Biological Process (BP) endomembrane system organization 0.1179 Highly Informative Inherited
Biological Process (BP) leukocyte migration 1 Highly Informative Inherited
Biological Process (BP) response to organophosphorus 0.1035 Highly Informative Inherited
Biological Process (BP) cellular response to organonitrogen compound 0.509 Highly Informative Inherited
Biological Process (BP) response to purine-containing compound 0.001008 Highly Informative Inherited
Biological Process (BP) cellular response to extracellular stimulus 0.98 Highly Informative Inherited
Biological Process (BP) divalent metal ion transport 0.003232 Highly Informative Inherited
Biological Process (BP) cytokine-mediated signaling pathway 0.2655 Highly Informative Inherited
Biological Process (BP) innate immune response 0.1296 Highly Informative Inherited
Biological Process (BP) sensory organ morphogenesis 0.05401 Highly Informative Inherited
Biological Process (BP) camera-type eye development 0.8933 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular component biogenesis 0.1802 Highly Informative Inherited
Biological Process (BP) positive regulation of nervous system development 0.335 Highly Informative Inherited
Biological Process (BP) histone modification 1 Highly Informative Inherited
Biological Process (BP) negative regulation of homeostatic process 0.006802 Highly Informative Inherited
Biological Process (BP) pigmentation 0.02089 Highly Informative Inherited
Biological Process (BP) negative regulation of peptide secretion 0.001375 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 0.002322 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 1 Highly Informative Inherited
Biological Process (BP) single-organism behavior 0.02865 Highly Informative Inherited
Biological Process (BP) positive regulation of protein transport 0.5837 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular protein localization 0.01974 Highly Informative Inherited
Biological Process (BP) cellular carbohydrate catabolic process 0.02107 Highly Informative Inherited
Biological Process (BP) regulation of lymphocyte proliferation 1 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 1 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 0.00505 Highly Informative Inherited
Biological Process (BP) multi-organism cellular process 0.04043 Highly Informative Inherited
Biological Process (BP) regulation of cysteine-type endopeptidase activity 0.9718 Highly Informative Inherited
Biological Process (BP) regulation of protein import into nucleus 0.01267 Highly Informative Inherited
Biological Process (BP) appendage development 1 Highly Informative Inherited
Biological Process (BP) peptidyl-lysine modification 0.9276 Highly Informative Inherited
Biological Process (BP) macromolecule methylation 0.5008 Highly Informative Inherited
Biological Process (BP) protein alkylation 0.1595 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular transport 0.00322 Highly Informative Inherited
Biological Process (BP) multicellular organism metabolic process 0.001051 Highly Informative Inherited
Biological Process (BP) positive regulation of lymphocyte activation 0.8381 Highly Informative Inherited
Biological Process (BP) activation of protein kinase activity 0.002495 Highly Informative Inherited
Biological Process (BP) response to nutrient levels 1 Highly Informative Inherited
Biological Process (BP) plasma membrane bounded cell projection organization 0.02378 Highly Informative Inherited
Biological Process (BP) epithelial cell differentiation 1 Highly Informative Inherited
Biological Process (BP) regulation of cell growth 0.003851 Highly Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 1 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.7645 Highly Informative Inherited
Biological Process (BP) brain development 0.5993 Highly Informative Inherited
Biological Process (BP) viral process 0.4307 Highly Informative Inherited
Biological Process (BP) macromolecule glycosylation 0.2547 Highly Informative Inherited
Biological Process (BP) pattern specification process 1 Highly Informative Inherited
Biological Process (BP) muscle structure development 0.209 Highly Informative Inherited
Biological Process (BP) gliogenesis 1 Highly Informative Inherited
Biological Process (BP) negative regulation of cell development 0.004435 Highly Informative Inherited
Biological Process (BP) regulation of epithelial cell migration 0.007117 Highly Informative Inherited
Biological Process (BP) regulation of calcium ion transport 0.0034 Highly Informative Inherited
Biological Process (BP) glycoprotein metabolic process 0.1586 Highly Informative Inherited
Biological Process (BP) response to carbohydrate 0.002763 Highly Informative Inherited
Biological Process (BP) neurological system process 1 Highly Informative Inherited
Biological Process (BP) signal release 0.02015 Highly Informative Inherited
Biological Process (BP) renal system process 0.05011 Highly Informative Inherited
Biological Process (BP) regulation of blood pressure 0.03466 Highly Informative Inherited
Biological Process (BP) regulation of epithelial cell proliferation 0.04353 Highly Informative Inherited
Biological Process (BP) wound healing 0.1436 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 1 Highly Informative Inherited
Biological Process (BP) RNA splicing 0.2423 Highly Informative Inherited
Molecular Function (MF) binding 0.03165 Least Informative Inherited
Molecular Function (MF) hydrolase activity 0.8272 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 0.00002395 Moderately Informative Direct
Molecular Function (MF) nucleic acid binding 1 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 1 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 1 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) metal ion binding 0.00428 Moderately Informative Inherited
Molecular Function (MF) structural molecule activity 0.01202 Moderately Informative Inherited
Molecular Function (MF) molecular function regulator 0.3815 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 1 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) signal transducer activity 0.000000000000004806 Informative Direct
Molecular Function (MF) receptor binding 0.0003877 Informative Direct
Molecular Function (MF) hydrolase activity, acting on glycosyl bonds 0 Informative Direct
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) sulfur compound binding 0.00000001683 Informative Direct
Molecular Function (MF) transferase activity, transferring one-carbon groups 1 Informative Inherited
Molecular Function (MF) enzyme activator activity 0.3919 Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 0.03418 Informative Inherited
Molecular Function (MF) metal ion transmembrane transporter activity 0.002082 Informative Inherited
Molecular Function (MF) passive transmembrane transporter activity 0.01029 Informative Inherited
Molecular Function (MF) macromolecular complex binding 0.02592 Informative Inherited
Molecular Function (MF) peptidase regulator activity 0.003743 Informative Inherited
Molecular Function (MF) enzyme inhibitor activity 0.02033 Informative Inherited
Molecular Function (MF) phosphatase activity 0.1665 Informative Inherited
Molecular Function (MF) kinase activity 1 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 1 Informative Inherited
Molecular Function (MF) peptidase activity, acting on L-amino acid peptides 1 Informative Inherited
Molecular Function (MF) RNA binding 1 Informative Inherited
Molecular Function (MF) phospholipid binding 0.02527 Informative Inherited
Molecular Function (MF) hydrolase activity, hydrolyzing O-glycosyl compounds 0 Highly Informative Direct
Molecular Function (MF) phosphoprotein phosphatase activity 0.00004429 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase inhibitor activity 0.0001107 Highly Informative Direct
Molecular Function (MF) calcium ion binding 0 Highly Informative Direct
Molecular Function (MF) heparin binding 0.000000000168 Highly Informative Direct
Molecular Function (MF) ubiquitin-like protein transferase activity 0 Highly Informative Direct
Molecular Function (MF) protein kinase regulator activity 0.0001503 Highly Informative Direct
Molecular Function (MF) gated channel activity 0.00005992 Highly Informative Direct
Molecular Function (MF) macromolecule transmembrane transporter activity 0.00001916 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase regulator activity involved in apoptotic process 0.0000001099 Highly Informative Direct
Molecular Function (MF) monosaccharide binding 0.0009578 Highly Informative Direct
Molecular Function (MF) cell adhesion molecule binding 0 Highly Informative Direct
Molecular Function (MF) modified amino acid binding 0.00000000007009 Highly Informative Direct
Molecular Function (MF) transferase activity, transferring hexosyl groups 0.1642 Highly Informative Inherited
Molecular Function (MF) ion channel activity 0.001901 Highly Informative Inherited
Molecular Function (MF) S-adenosylmethionine-dependent methyltransferase activity 0.9638 Highly Informative Inherited
Molecular Function (MF) protein transporter activity 0.009925 Highly Informative Inherited
Molecular Function (MF) amide transmembrane transporter activity 0.003982 Highly Informative Inherited
Molecular Function (MF) transmembrane signaling receptor activity 1 Highly Informative Inherited
Molecular Function (MF) protein kinase activity 1 Highly Informative Inherited
Molecular Function (MF) metallopeptidase activity 0.008346 Highly Informative Inherited
Cellular Component (CC) membrane 0.0002167 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) macromolecular complex 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.3803 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.00000005478 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) bounding membrane of organelle 0.97 Moderately Informative Inherited
Cellular Component (CC) intrinsic component of membrane 0.715 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) transferase complex 1 Moderately Informative Inherited
Cellular Component (CC) cell projection 0.001443 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum membrane 0 Informative Direct
Cellular Component (CC) ribonucleoprotein granule 0.00000000000003201 Informative Direct
Cellular Component (CC) extracellular organelle 0.00001099 Informative Direct
Cellular Component (CC) synapse 0.00000000339 Informative Direct
Cellular Component (CC) transporter complex 0.1358 Informative Inherited
Cellular Component (CC) supramolecular polymer 0.04774 Informative Inherited
Cellular Component (CC) plasma membrane region 0.357 Informative Inherited
Cellular Component (CC) nucleoplasm part 0.8657 Informative Inherited
Cellular Component (CC) plasma membrane bounded cell projection part 1 Informative Inherited
Cellular Component (CC) neuron projection 0.1522 Informative Inherited
Cellular Component (CC) external encapsulating structure 0.003619 Informative Inherited
Cellular Component (CC) Golgi apparatus 0.02638 Informative Inherited
Cellular Component (CC) P-body 0.00000001605 Highly Informative Direct
Cellular Component (CC) sarcoplasm 0 Highly Informative Direct
Cellular Component (CC) lamellipodium 0.00007182 Highly Informative Direct
Cellular Component (CC) extracellular matrix component 0 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 0.00001832 Highly Informative Direct
Cellular Component (CC) tRNA-splicing ligase complex 0.000000000001175 Highly Informative Direct
Cellular Component (CC) nuclear body 0.1676 Highly Informative Inherited
Cellular Component (CC) cell-cell junction 0.8478 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides1Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)1Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0.000000000002215Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an0.1378Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0.07915Moderately InformativeInherited
Enzyme Commission (EC)Metalloendopeptidases0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0.00000001837InformativeDirect
Enzyme Commission (EC)Cellulose 1,4-beta-cellobiosidase (non-reducing en0Highly InformativeDirect
Enzyme Commission (EC)Bontoxilysin0.000000000000213Highly InformativeDirect
Enzyme Commission (EC)Alpha-N-arabinofuranosidase0.0001267Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the eye0.173Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.3229Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.4626Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.1417Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the posterior segment of the globe0.4623Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of long bone morphology0.4871Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of lower limb bone0.6298Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the retina0.07298InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the femur0.07833InformativeInherited
Phenotypic Abnormality (PA)Abnormality of epiphysis morphology0.08308InformativeInherited
Phenotypic Abnormality (PA)Osteoarthritis0.0003625Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of femoral epiphysis0.0004337Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.02396Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.8904Least InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development0.3755Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.8174Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal spinal cord morphology0.5037InformativeInherited
Mammalian Phenotype (MP)abnormal spinal cord ventral commissure morphology0.0002286Highly InformativeDirect
Mammalian Phenotype (MP)abnormal basement membrane morphology0.0005218Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

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WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organ system morphology variant0.09667Least InformativeInherited
Worm Phenotype (WP)cell development variant0.1253Least InformativeInherited
Worm Phenotype (WP)cell morphology variant0.1608Least InformativeInherited
Worm Phenotype (WP)nervous system morphology variant0.005887Moderately InformativeInherited
Worm Phenotype (WP)neuronal outgrowth variant0.2618InformativeInherited
Worm Phenotype (WP)axon morphology variant0.000001981Highly InformativeDirect
Worm Phenotype (WP)axon guidance variant0.00001865Highly InformativeDirect
Worm Phenotype (WP)cell polarity variant0.0004403Highly InformativeDirect
Worm Phenotype (WP)myopodia present0.0007707Highly InformativeDirect
Worm Phenotype (WP)muscle arm development defective0.0009765Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

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FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)cell polarity defective0.0002139InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

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XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus DEvelopment stage (XDE)NF stage0.00005064Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)root system0.4785Least InformativeInherited
Plant ANatomical entity (PAN)leaf0.8409Least InformativeInherited
Plant ANatomical entity (PAN)root epidermis0.001718InformativeInherited
Plant ANatomical entity (PAN)adult vascular leaf0.0007043Highly InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

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