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Concanavalin A-like lectins/glucanases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Concanavalin A-like lectins/glucanases [ 49898]
Superfamily:   Concanavalin A-like lectins/glucanases [ 49899] (25)
Families:   Legume lectins [ 49900] (4)
  Lectin leg-like [ 74904] (3)
  Glycosyl hydrolases family 16 [ 49925] (5)
  Galectin (animal S-lectin) [ 49932] (8)
  Laminin G-like module [ 49944] (6)
  Thrombospondin C-terminal domain [ 101643]
  Pentraxin (pentaxin) [ 49951] (2)
  Calnexin/calreticulin [ 69236]
  vp4 sialic acid binding domain [ 74907]
  Hypothetical protein YesU [ 101646]
  Alginate lyase [ 101649] (3)
  Clostridium neurotoxins, the second last domain [ 49956] (2)
  Exotoxin A, N-terminal domain [ 49962]
  Vibrio cholerae sialidase, N-terminal and insertion domains [ 49965]
  Leech intramolecular trans-sialidase, N-terminal domain [ 49968]
  Trypanosoma sialidase, C-terminal domain [ 82038]
  Glycosyl hydrolase family 7 catalytic core [ 49971]
  Glycosyl hydrolases family 32 C-terminal domain [ 101652] (2)
  Xylanase/endoglucanase 11/12 [ 49978] (2)
  Peptidase A4 [ 101656] (2)
  Alpha-L-arabinofuranosidase B, N-terminal domain [ 110143]
  SPRY domain [ 141154] (5)
  Beta-D-xylosidase C-terminal domain-like [ 141161]
  SO2946-like [ 141167]
  MAM domain [ 141170]


Superfamily statistics
Genomes (2,190) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 63,769 113,303 236
Proteins 50,496 98,511 228


Functional annotation
General category Metabolism
Detailed category Secondary metabolism

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biological regulation0.89420.00005759Least InformativeInherited
Biological Process (BP)macromolecule metabolic process0.15560.8359Least InformativeInherited
Biological Process (BP)primary metabolic process11Least InformativeInherited
Biological Process (BP)carbohydrate metabolic process0.0000000032820.000005027Moderately InformativeDirect
Biological Process (BP)regulation of multicellular organismal process0.00092930.00000000344Moderately InformativeDirect
Biological Process (BP)regulation of localization0.32960.001857Moderately InformativeInherited
Biological Process (BP)system development0.018150.00000000006006Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.035181Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.17910.00000000004142Moderately InformativeInherited
Biological Process (BP)polysaccharide metabolic process00.000000000004234InformativeDirect
Biological Process (BP)carbohydrate catabolic process0.0000000074910.0000005673InformativeDirect
Biological Process (BP)regulation of secretion0.0022940.00866InformativeInherited
Biological Process (BP)regulation of protein localization0.0039740.1741InformativeInherited
Biological Process (BP)regulation of cytokine production0.00014560.003614InformativeInherited
Biological Process (BP)circulatory system development0.040650.001499InformativeInherited
Biological Process (BP)regulation of cell proliferation0.31110.07751InformativeInherited
Biological Process (BP)anatomical structure formation involved in morphogenesis0.014640.02596InformativeInherited
Biological Process (BP)cell wall macromolecule metabolic process00Highly InformativeDirect
Biological Process (BP)polysaccharide catabolic process0.0000000023210.0000000007819Highly InformativeDirect
Biological Process (BP)angiogenesis0.000036050.0000001669Highly InformativeDirect
Biological Process (BP)regulation of cytokine secretion0.0002450.0000000001088Highly InformativeDirect
Biological Process (BP)regulation of T cell activation0.00073351Highly InformativeInherited
Biological Process (BP)regulation of lymphocyte proliferation0.44511Highly InformativeInherited
Molecular Function (MF)binding0.14230.002236Least InformativeInherited
Molecular Function (MF)hydrolase activity0.015310.7951Least InformativeInherited
Molecular Function (MF)transferase activity0.95861Least InformativeInherited
Molecular Function (MF)protein binding10.2654Moderately InformativeInherited
Molecular Function (MF)carbohydrate derivative binding0.019890.0002091Moderately InformativeInherited
Molecular Function (MF)hydrolase activity, acting on glycosyl bonds00InformativeDirect
Molecular Function (MF)transferase activity, transferring glycosyl groups0.000022460.0007001InformativeDirect
Molecular Function (MF)hydrolase activity, hydrolyzing O-glycosyl compounds00Highly InformativeDirect
Molecular Function (MF)transferase activity, transferring hexosyl groups0.00000056430.0491Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) response to stimulus 0.00000004072 Least Informative Direct
Biological Process (BP) biological regulation 0.00005759 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.2408 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 0.8359 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.000005027 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.00000000344 Moderately Informative Direct
Biological Process (BP) system development 0.00000000006006 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.00000158 Moderately Informative Direct
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.00000000004142 Moderately Informative Direct
Biological Process (BP) response to external stimulus 0 Moderately Informative Direct
Biological Process (BP) cellular developmental process 0 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.000485 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0.000000008801 Moderately Informative Direct
Biological Process (BP) signaling 0.000001025 Moderately Informative Direct
Biological Process (BP) regulation of signaling 0.000000000001283 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 0.000000000001924 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.9648 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.001857 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.9266 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.08972 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) cell communication 0.001913 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.02491 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.003682 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) response to stress 0.9556 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.01742 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.00615 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.02783 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.01705 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.002935 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.08752 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) polysaccharide metabolic process 0.000000000004234 Informative Direct
Biological Process (BP) carbohydrate catabolic process 0.0000005673 Informative Direct
Biological Process (BP) immune response 0.000000001272 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.000000000000003692 Informative Direct
Biological Process (BP) regulation of immune response 0.00005457 Informative Direct
Biological Process (BP) generation of neurons 0.000139 Informative Direct
Biological Process (BP) defense response to other organism 0.0000004658 Informative Direct
Biological Process (BP) positive regulation of immune system process 0.000000001103 Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.0000000000001067 Informative Direct
Biological Process (BP) cell development 0.000000000007431 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) regulation of defense response 0.0000000000001739 Informative Direct
Biological Process (BP) positive regulation of signal transduction 0.000000000002478 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0.00000002768 Informative Direct
Biological Process (BP) positive regulation of phosphate metabolic process 0.000004971 Informative Direct
Biological Process (BP) positive regulation of cellular protein metabolic process 0.000005033 Informative Direct
Biological Process (BP) regulation of locomotion 0.00002482 Informative Direct
Biological Process (BP) regulation of growth 0.00009413 Informative Direct
Biological Process (BP) single-organism membrane organization 0.0001262 Informative Direct
Biological Process (BP) response to cytokine 0.0001467 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.0003703 Informative Direct
Biological Process (BP) regulation of protein modification process 0.0006111 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.0008971 Informative Direct
Biological Process (BP) negative regulation of molecular function 1 Informative Inherited
Biological Process (BP) negative regulation of cell death 1 Informative Inherited
Biological Process (BP) ion homeostasis 1 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.2389 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.707 Informative Inherited
Biological Process (BP) regulation of protein localization 0.1741 Informative Inherited
Biological Process (BP) regulation of cellular localization 0.4061 Informative Inherited
Biological Process (BP) regulation of system process 0.9026 Informative Inherited
Biological Process (BP) organelle assembly 1 Informative Inherited
Biological Process (BP) response to nitrogen compound 1 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.2613 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.2034 Informative Inherited
Biological Process (BP) protein oligomerization 0.009457 Informative Inherited
Biological Process (BP) regulation of transferase activity 0.7425 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 0.002478 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 0.9407 Informative Inherited
Biological Process (BP) regulation of proteolysis 0.06111 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.06539 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.269 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 0.1049 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.1114 Informative Inherited
Biological Process (BP) transmembrane transport 0.7818 Informative Inherited
Biological Process (BP) positive regulation of transport 0.8649 Informative Inherited
Biological Process (BP) regulation of secretion 0.00866 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.003614 Informative Inherited
Biological Process (BP) behavior 0.3709 Informative Inherited
Biological Process (BP) negative regulation of transport 0.001963 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 0.1638 Informative Inherited
Biological Process (BP) pigment metabolic process 0.1363 Informative Inherited
Biological Process (BP) negative regulation of cellular protein metabolic process 0.09096 Informative Inherited
Biological Process (BP) regulation of cell differentiation 0.03342 Informative Inherited
Biological Process (BP) multi-organism cellular process 0.2518 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 1 Informative Inherited
Biological Process (BP) response to bacterium 0.139 Informative Inherited
Biological Process (BP) regulation of apoptotic process 1 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 1 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 1 Informative Inherited
Biological Process (BP) negative regulation of gene expression 1 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 1 Informative Inherited
Biological Process (BP) regulation of phosphorylation 0.01834 Informative Inherited
Biological Process (BP) response to inorganic substance 1 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.001546 Informative Inherited
Biological Process (BP) regulation of transcription, DNA-templated 1 Informative Inherited
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 0.007597 Informative Inherited
Biological Process (BP) central nervous system development 1 Informative Inherited
Biological Process (BP) monosaccharide metabolic process 0.2277 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.1804 Informative Inherited
Biological Process (BP) phosphorylation 1 Informative Inherited
Biological Process (BP) system process 0.232 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.006548 Informative Inherited
Biological Process (BP) embryo development 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.02596 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) regulation of ion transport 0.4798 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.09229 Informative Inherited
Biological Process (BP) secretion 0.02508 Informative Inherited
Biological Process (BP) cell adhesion 1 Informative Inherited
Biological Process (BP) metal ion transport 0.4206 Informative Inherited
Biological Process (BP) single-organism intracellular transport 0.8679 Informative Inherited
Biological Process (BP) protein targeting 0.2717 Informative Inherited
Biological Process (BP) tRNA metabolic process 0.6367 Informative Inherited
Biological Process (BP) ncRNA processing 1 Informative Inherited
Biological Process (BP) growth 0.3747 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.4666 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.07751 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) circulatory system development 0.001499 Informative Inherited
Biological Process (BP) cell wall macromolecule metabolic process 0 Highly Informative Direct
Biological Process (BP) polysaccharide catabolic process 0.0000000007819 Highly Informative Direct
Biological Process (BP) angiogenesis 0.0000001669 Highly Informative Direct
Biological Process (BP) regulation of cytokine secretion 0.0000000001088 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 0.000000000000003692 Highly Informative Direct
Biological Process (BP) defense response to bacterium 0.0004531 Highly Informative Direct
Biological Process (BP) cell projection organization 0 Highly Informative Direct
Biological Process (BP) cell migration 0 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 0 Highly Informative Direct
Biological Process (BP) chemotaxis 0 Highly Informative Direct
Biological Process (BP) regulation of sequence-specific DNA binding transcription factor activity 0 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0 Highly Informative Direct
Biological Process (BP) neuron development 0.000000000000003692 Highly Informative Direct
Biological Process (BP) protein modification by small protein conjugation 0.0000000002632 Highly Informative Direct
Biological Process (BP) negative regulation of locomotion 0.0000000003322 Highly Informative Direct
Biological Process (BP) synaptic signaling 0.00000001688 Highly Informative Direct
Biological Process (BP) regulation of viral life cycle 0.00000006721 Highly Informative Direct
Biological Process (BP) response to drug 0.00000008351 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.0000004472 Highly Informative Direct
Biological Process (BP) negative regulation of secretion by cell 0.0000004963 Highly Informative Direct
Biological Process (BP) vesicle-mediated transport to the plasma membrane 0.000001247 Highly Informative Direct
Biological Process (BP) negative regulation of growth 0.000001871 Highly Informative Direct
Biological Process (BP) negative regulation of multi-organism process 0.00001259 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 0.00003764 Highly Informative Direct
Biological Process (BP) positive regulation of MAPK cascade 0.00005314 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.00007356 Highly Informative Direct
Biological Process (BP) negative regulation of cellular component movement 0.00007868 Highly Informative Direct
Biological Process (BP) regulation of fibroblast proliferation 0.00008818 Highly Informative Direct
Biological Process (BP) cell junction assembly 0.00009414 Highly Informative Direct
Biological Process (BP) gastrulation 0.000274 Highly Informative Direct
Biological Process (BP) regulation of neurotransmitter levels 0.0003199 Highly Informative Direct
Biological Process (BP) regulation of cell size 0.0003306 Highly Informative Direct
Biological Process (BP) muscle system process 0.0003468 Highly Informative Direct
Biological Process (BP) negative regulation of cellular protein localization 0.0004085 Highly Informative Direct
Biological Process (BP) negative regulation of establishment of protein localization 0.0004394 Highly Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 0.000441 Highly Informative Direct
Biological Process (BP) regulation of ion homeostasis 0.0005797 Highly Informative Direct
Biological Process (BP) response to purine-containing compound 0.0006196 Highly Informative Direct
Biological Process (BP) multicellular organism metabolic process 0.0006906 Highly Informative Direct
Biological Process (BP) positive regulation of intracellular transport 0.0007302 Highly Informative Direct
Biological Process (BP) negative regulation of endopeptidase activity 0.007737 Highly Informative Inherited
Biological Process (BP) divalent inorganic cation transport 0.001421 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.1395 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 0.3766 Highly Informative Inherited
Biological Process (BP) endomembrane system organization 0.1066 Highly Informative Inherited
Biological Process (BP) cellular response to organonitrogen compound 0.3827 Highly Informative Inherited
Biological Process (BP) response to carbohydrate 0.002286 Highly Informative Inherited
Biological Process (BP) inorganic cation transmembrane transport 0.004035 Highly Informative Inherited
Biological Process (BP) regulation of cell growth 0.003533 Highly Informative Inherited
Biological Process (BP) innate immune response 0.2363 Highly Informative Inherited
Biological Process (BP) cytokine-mediated signaling pathway 0.2353 Highly Informative Inherited
Biological Process (BP) sensory organ morphogenesis 0.1393 Highly Informative Inherited
Biological Process (BP) positive regulation of nervous system development 0.2494 Highly Informative Inherited
Biological Process (BP) peptidyl-lysine modification 0.9471 Highly Informative Inherited
Biological Process (BP) histone modification 0.9273 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular component biogenesis 0.07838 Highly Informative Inherited
Biological Process (BP) negative regulation of homeostatic process 0.004603 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 0.02167 Highly Informative Inherited
Biological Process (BP) vesicle localization 0.02674 Highly Informative Inherited
Biological Process (BP) establishment of organelle localization 0.6014 Highly Informative Inherited
Biological Process (BP) single-organism behavior 0.03241 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular protein localization 0.0295 Highly Informative Inherited
Biological Process (BP) pigmentation 0.01404 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 1 Highly Informative Inherited
Biological Process (BP) regulation of lymphocyte proliferation 1 Highly Informative Inherited
Biological Process (BP) negative regulation of cell development 0.002388 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 0.002583 Highly Informative Inherited
Biological Process (BP) regulation of cysteine-type endopeptidase activity 0.9845 Highly Informative Inherited
Biological Process (BP) appendage development 1 Highly Informative Inherited
Biological Process (BP) regulation of protein import into nucleus 0.002788 Highly Informative Inherited
Biological Process (BP) negative regulation of RNA metabolic process 1 Highly Informative Inherited
Biological Process (BP) positive regulation of lymphocyte activation 0.7317 Highly Informative Inherited
Biological Process (BP) response to nutrient levels 0.9697 Highly Informative Inherited
Biological Process (BP) chromosome organization 1 Highly Informative Inherited
Biological Process (BP) activation of protein kinase activity 0.002292 Highly Informative Inherited
Biological Process (BP) cellular response to external stimulus 1 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.6912 Highly Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 1 Highly Informative Inherited
Biological Process (BP) brain development 0.7388 Highly Informative Inherited
Biological Process (BP) viral life cycle 0.193 Highly Informative Inherited
Biological Process (BP) macromolecule glycosylation 0.2342 Highly Informative Inherited
Biological Process (BP) macromolecule methylation 0.4333 Highly Informative Inherited
Biological Process (BP) pattern specification process 1 Highly Informative Inherited
Biological Process (BP) cellular calcium ion homeostasis 0.002002 Highly Informative Inherited
Biological Process (BP) gliogenesis 1 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 1 Highly Informative Inherited
Biological Process (BP) camera-type eye development 0.9344 Highly Informative Inherited
Biological Process (BP) regulation of epithelial cell migration 0.03656 Highly Informative Inherited
Biological Process (BP) regulation of calcium ion transport 0.002123 Highly Informative Inherited
Biological Process (BP) glycoprotein metabolic process 0.1683 Highly Informative Inherited
Biological Process (BP) muscle structure development 0.1427 Highly Informative Inherited
Biological Process (BP) signal release 0.023 Highly Informative Inherited
Biological Process (BP) endocytosis 0.1818 Highly Informative Inherited
Biological Process (BP) establishment of protein localization to membrane 0.0196 Highly Informative Inherited
Biological Process (BP) RNA splicing 0.1909 Highly Informative Inherited
Biological Process (BP) oligosaccharide metabolic process 0.1525 Highly Informative Inherited
Biological Process (BP) regulation of blood pressure 0.02903 Highly Informative Inherited
Biological Process (BP) renal system process 0.02876 Highly Informative Inherited
Biological Process (BP) regulation of epithelial cell proliferation 0.09127 Highly Informative Inherited
Biological Process (BP) wound healing 0.1509 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 1 Highly Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) binding 0.002236 Least Informative Inherited
Molecular Function (MF) hydrolase activity 0.7951 Least Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 0.0002091 Moderately Informative Direct
Molecular Function (MF) molecular function regulator 0.301 Moderately Informative Inherited
Molecular Function (MF) protein binding 0.2654 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 1 Moderately Informative Inherited
Molecular Function (MF) metal ion binding 0.01526 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) structural molecule activity 0.002073 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 1 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 1 Moderately Informative Inherited
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on glycosyl bonds 0 Informative Direct
Molecular Function (MF) transferase activity, transferring glycosyl groups 0.0007001 Informative Direct
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) signal transducer activity 8.405e-16 Informative Direct
Molecular Function (MF) sulfur compound binding 0.000000009113 Informative Direct
Molecular Function (MF) receptor binding 0.001667 Informative Inherited
Molecular Function (MF) RNA binding 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring one-carbon groups 1 Informative Inherited
Molecular Function (MF) enzyme activator activity 0.3437 Informative Inherited
Molecular Function (MF) metal ion transmembrane transporter activity 0.001258 Informative Inherited
Molecular Function (MF) macromolecular complex binding 0.08796 Informative Inherited
Molecular Function (MF) passive transmembrane transporter activity 0.007834 Informative Inherited
Molecular Function (MF) peptidase regulator activity 0.003002 Informative Inherited
Molecular Function (MF) enzyme inhibitor activity 0.01579 Informative Inherited
Molecular Function (MF) phosphoric ester hydrolase activity 0.8233 Informative Inherited
Molecular Function (MF) peptidase activity, acting on L-amino acid peptides 1 Informative Inherited
Molecular Function (MF) phospholipid binding 0.004773 Informative Inherited
Molecular Function (MF) hydrolase activity, hydrolyzing O-glycosyl compounds 0 Highly Informative Direct
Molecular Function (MF) calcium ion binding 0 Highly Informative Direct
Molecular Function (MF) ubiquitin-like protein transferase activity 0 Highly Informative Direct
Molecular Function (MF) heparin binding 0.00000000006642 Highly Informative Direct
Molecular Function (MF) modified amino acid binding 0.00000000006762 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase regulator activity involved in apoptotic process 0.00000007766 Highly Informative Direct
Molecular Function (MF) macromolecule transmembrane transporter activity 0.00001886 Highly Informative Direct
Molecular Function (MF) gated channel activity 0.00002129 Highly Informative Direct
Molecular Function (MF) protein kinase regulator activity 0.0001026 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase inhibitor activity 0.0001075 Highly Informative Direct
Molecular Function (MF) phosphoprotein phosphatase activity 0.0002925 Highly Informative Direct
Molecular Function (MF) S-adenosylmethionine-dependent methyltransferase activity 0.9266 Highly Informative Inherited
Molecular Function (MF) transferase activity, transferring hexosyl groups 0.0491 Highly Informative Inherited
Molecular Function (MF) protein transporter activity 0.00691 Highly Informative Inherited
Molecular Function (MF) ion channel activity 0.001299 Highly Informative Inherited
Molecular Function (MF) transmembrane signaling receptor activity 1 Highly Informative Inherited
Molecular Function (MF) metallopeptidase activity 0.006511 Highly Informative Inherited
Cellular Component (CC) membrane 0.0005182 Least Informative Direct
Cellular Component (CC) protein complex 0.3493 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.1557 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) vesicle 0.0009021 Moderately Informative Direct
Cellular Component (CC) endoplasmic reticulum 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.00001589 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) transferase complex 1 Moderately Informative Inherited
Cellular Component (CC) cell projection 0.003245 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 1 Moderately Informative Inherited
Cellular Component (CC) extracellular organelle 0.00008575 Informative Direct
Cellular Component (CC) endoplasmic reticulum membrane 0 Informative Direct
Cellular Component (CC) ribonucleoprotein granule 0.000000000000003057 Informative Direct
Cellular Component (CC) synapse 0.0000000005064 Informative Direct
Cellular Component (CC) lipid particle 0.000000006474 Informative Direct
Cellular Component (CC) cell junction 0.0002521 Informative Direct
Cellular Component (CC) nucleoplasm part 0.6232 Informative Inherited
Cellular Component (CC) neuron projection 0.07142 Informative Inherited
Cellular Component (CC) cell projection part 0.2763 Informative Inherited
Cellular Component (CC) external encapsulating structure 0.001683 Informative Inherited
Cellular Component (CC) Golgi apparatus 0.01766 Informative Inherited
Cellular Component (CC) extracellular matrix 0 Highly Informative Direct
Cellular Component (CC) sarcoplasm 0 Highly Informative Direct
Cellular Component (CC) tRNA-splicing ligase complex 0.000000000001119 Highly Informative Direct
Cellular Component (CC) cytoplasmic mRNA processing body 0.000000001532 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 0.00009386 Highly Informative Direct
Cellular Component (CC) lamellipodium 0.0002569 Highly Informative Direct
Cellular Component (CC) cell-cell junction 0.9275 Highly Informative Inherited
Cellular Component (CC) anchoring junction 0.08051 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides1Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)1Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0.000000000002215Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an0.1378Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0.07915Moderately InformativeInherited
Enzyme Commission (EC)Metalloendopeptidases0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0.00000001837InformativeDirect
Enzyme Commission (EC)Cellulose 1,4-beta-cellobiosidase (non-reducing en0Highly InformativeDirect
Enzyme Commission (EC)Bontoxilysin0.000000000000213Highly InformativeDirect
Enzyme Commission (EC)Alpha-N-arabinofuranosidase0.0001267Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the eye0.1728Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.3198Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.4586Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the posterior segment of the globe0.4066Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of long bone morphology0.4892Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of lower limb bone0.6299Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the retina0.07631InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the femur0.07933InformativeInherited
Phenotypic Abnormality (PA)Abnormality of epiphysis morphology0.08746InformativeInherited
Phenotypic Abnormality (PA)Abnormality of femoral epiphysis0.0004546Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.01956Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.8908Least InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development0.3756Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.8087Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal spinal cord morphology0.4982InformativeInherited
Mammalian Phenotype (MP)abnormal spinal cord ventral commissure morphology0.0002282Highly InformativeDirect
Mammalian Phenotype (MP)abnormal basement membrane morphology0.000523Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organ system morphology variant0.1082Least InformativeInherited
Worm Phenotype (WP)cell morphology variant0.1132Least InformativeInherited
Worm Phenotype (WP)cell development variant0.123Least InformativeInherited
Worm Phenotype (WP)nervous system morphology variant0.003731Moderately InformativeInherited
Worm Phenotype (WP)neuronal outgrowth variant0.2416InformativeInherited
Worm Phenotype (WP)axon morphology variant0.000001835Highly InformativeDirect
Worm Phenotype (WP)axon guidance variant0.00001492Highly InformativeDirect
Worm Phenotype (WP)cell polarity variant0.0004407Highly InformativeDirect
Worm Phenotype (WP)myopodia present0.0007629Highly InformativeDirect
Worm Phenotype (WP)muscle arm development defective0.0008962Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)cell polarity defective0.0002169InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus DEvelopment stage (XDE)NF stage0.0001024Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)root system0.4785Least InformativeInherited
Plant ANatomical entity (PAN)leaf0.8409Least InformativeInherited
Plant ANatomical entity (PAN)root epidermis0.001718InformativeInherited
Plant ANatomical entity (PAN)adult vascular leaf0.0007043Highly InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorus-containing groups1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosylases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0.00000000008741Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.1649Moderately InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptidases)1Moderately InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides1Moderately InformativeInherited
Enzyme Commission (EC)Hexosyltransferases0InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect
Enzyme Commission (EC)Metalloendopeptidases0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0.00000006706InformativeDirect
Enzyme Commission (EC)RNA helicase0.0008217InformativeDirect
Enzyme Commission (EC)Serine endopeptidases1InformativeInherited
Enzyme Commission (EC)Enteropeptidase0.000000000001392Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

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KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processDifferentiation0Moderately InformativeDirect
Biological processImmunity0Moderately InformativeDirect
Biological processUbl conjugation pathway0Moderately InformativeDirect
Biological processHost-virus interaction0Moderately InformativeDirect
Biological processVirulence0.00000000001737Moderately InformativeDirect
Biological processApoptosis0.00000000001751Moderately InformativeDirect
Biological processIon transport1Moderately InformativeInherited
Biological processAngiogenesis0InformativeDirect
Biological processAutophagy0InformativeDirect
Biological processCell adhesion0InformativeDirect
Biological processNeurogenesis0InformativeDirect
Biological processPolysaccharide degradation0InformativeDirect
Biological processVirus entry into host cell0InformativeDirect
Biological processCell wall biogenesis/degradation0.0000000000003094InformativeDirect
Biological processPlant defense0.0000000000003503InformativeDirect
Biological processInnate immunity0.000000006936InformativeDirect
Biological processHemostasis0.0001149InformativeDirect
Biological processAntiviral defense0Highly InformativeDirect
Biological processCalcium transport0.0000000000001553Highly InformativeDirect
Biological processAcute phase0.000000000001144Highly InformativeDirect
Biological processUnfolded protein response0.00000000005321Highly InformativeDirect
Biological processBlood coagulation0.0001094Highly InformativeDirect
Biological processExocytosis0.0001234Highly InformativeDirect
Cellular componentMembrane0.00000000008414Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentVirion0Moderately InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentGolgi apparatus0.000004723Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.00005252Moderately InformativeDirect
Cellular componentCapsid protein0InformativeDirect
Cellular componentExtracellular matrix0InformativeDirect
Cellular componentVacuole0InformativeDirect
Cellular componentGPI-anchor0.000000000003284InformativeDirect
Cellular componentSynapse0.00006164InformativeDirect
Cellular componentCell wall0Highly InformativeDirect
Cellular componentSarcoplasmic reticulum0Highly InformativeDirect
Cellular componentHost endoplasmic reticulum0Highly InformativeDirect
Coding sequence diversityAlternative splicing0.0001008Least InformativeDirect
Coding sequence diversityAlternative promoter usage0Moderately InformativeDirect
DiseaseDisease mutation0.0001007Least InformativeDirect
DiseaseDeafness0.0001761InformativeDirect
DiseaseDwarfism0.0004537InformativeDirect
DomainSignal0Least InformativeDirect
DomainRepeat0.00002015Least InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
DomainZinc-finger0.000001348Moderately InformativeDirect
DomainEGF-like domain0InformativeDirect
DomainCollagen0Highly InformativeDirect
DomainLaminin EGF-like domain0Highly InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionMetal-binding0.0009004Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionManganese0.000003688Moderately InformativeDirect
Molecular functionLipid-binding0.7043Moderately InformativeInherited
Molecular functionHeparin-binding0InformativeDirect
Molecular functionLectin0InformativeDirect
Molecular functionCalmodulin-binding0.00002737InformativeDirect
Molecular functionSteroid-binding0.00001402Highly InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationKinase1Moderately InformativeInherited
Post-translational modificationProtease1Moderately InformativeInherited
Post-translational modificationGlycosidase0InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0.0000000108InformativeDirect
Post-translational modificationToxin0.000003636InformativeDirect
Post-translational modificationMetalloprotease0.0006065InformativeDirect
Post-translational modificationIon channel0.01763InformativeInherited
Post-translational modificationHemagglutinin0Highly InformativeDirect
Post-translational modificationCalcium channel0.0000000000003317Highly InformativeDirect
Post-translational modificationLigand-gated ion channel0.000000004313Highly InformativeDirect
Post-translational modificationMitogen0.00002412Highly InformativeDirect
Post-translational modificationNeurotoxin0.0009545Highly InformativeDirect
Post-translational modificationStorage protein0.002007Highly InformativeInherited
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationHydroxylation0InformativeDirect
Post-translational modificationProteoglycan0.002264InformativeInherited
Post-translational modificationHeparan sulfate0.00000000008464Highly InformativeDirect
Post-translational modificationPeptidoglycan-anchor0.00001056Highly InformativeDirect
Post-translational modificationGamma-carboxyglutamic acid0.0000716Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

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