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Concanavalin A-like lectins/glucanases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Concanavalin A-like lectins/glucanases [ 49898]
Superfamily:   Concanavalin A-like lectins/glucanases [ 49899] (25)
Families:   Legume lectins [ 49900] (4)
  Lectin leg-like [ 74904] (3)
  Glycosyl hydrolases family 16 [ 49925] (5)
  Galectin (animal S-lectin) [ 49932] (8)
  Laminin G-like module [ 49944] (6)
  Thrombospondin C-terminal domain [ 101643]
  Pentraxin (pentaxin) [ 49951] (2)
  Calnexin/calreticulin [ 69236]
  vp4 sialic acid binding domain [ 74907]
  Hypothetical protein YesU [ 101646]
  Alginate lyase [ 101649] (3)
  Clostridium neurotoxins, the second last domain [ 49956] (2)
  Exotoxin A, N-terminal domain [ 49962]
  Vibrio cholerae sialidase, N-terminal and insertion domains [ 49965]
  Leech intramolecular trans-sialidase, N-terminal domain [ 49968]
  Trypanosoma sialidase, C-terminal domain [ 82038]
  Glycosyl hydrolase family 7 catalytic core [ 49971]
  Glycosyl hydrolases family 32 C-terminal domain [ 101652] (2)
  Xylanase/endoglucanase 11/12 [ 49978] (2)
  Peptidase A4 [ 101656] (2)
  Alpha-L-arabinofuranosidase B, N-terminal domain [ 110143]
  SPRY domain [ 141154] (5)
  Beta-D-xylosidase C-terminal domain-like [ 141161]
  SO2946-like [ 141167]
  MAM domain [ 141170]

Superfamily statistics
Genomes (2,197) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 65,045 0 236
Proteins 51,285 0 228

Functional annotation
General category Metabolism
Detailed category Secondary metabolism

Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides1Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)1Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0.000000000002215Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an0.1378Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0.07915Moderately InformativeInherited
Enzyme Commission (EC)Metalloendopeptidases0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0.00000001837InformativeDirect
Enzyme Commission (EC)Cellulose 1,4-beta-cellobiosidase (non-reducing en0Highly InformativeDirect
Enzyme Commission (EC)Bontoxilysin0.000000000000213Highly InformativeDirect
Enzyme Commission (EC)Alpha-N-arabinofuranosidase0.0001267Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the eye0.1228Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the skeletal system0.2708Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.4723Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.09584Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal fundus morphology0.2631Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.3305Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limb bone morphology0.733Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal retinal morphology0.2042InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the thorax0.2274InformativeInherited
Phenotypic Abnormality (PA)Abnormality of long bone morphology0.4508InformativeInherited
Phenotypic Abnormality (PA)Abnormality of lower limb bone0.4776InformativeInherited
Phenotypic Abnormality (PA)Osteoarthritis0.0005506Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of epiphysis morphology0.05717Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ribs0.2053Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.02387Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.8896Least InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development0.3732Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.8153Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal spinal cord morphology0.5022InformativeInherited
Mammalian Phenotype (MP)abnormal spinal cord ventral commissure morphology0.0002292Highly InformativeDirect
Mammalian Phenotype (MP)abnormal basement membrane morphology0.0005227Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organ system morphology variant0.1012Least InformativeInherited
Worm Phenotype (WP)cell development variant0.129Least InformativeInherited
Worm Phenotype (WP)cell morphology variant0.1723Least InformativeInherited
Worm Phenotype (WP)nervous system morphology variant0.006412Moderately InformativeInherited
Worm Phenotype (WP)neuronal outgrowth variant0.2968InformativeInherited
Worm Phenotype (WP)axon morphology variant0.000002103Highly InformativeDirect
Worm Phenotype (WP)axon guidance variant0.00002075Highly InformativeDirect
Worm Phenotype (WP)cell polarity variant0.0005889Highly InformativeDirect
Worm Phenotype (WP)myopodia present0.0007772Highly InformativeDirect
Worm Phenotype (WP)muscle arm development defective0.0009853Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)cell polarity defective0.00004071InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)organism subdivision0.8807Least InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.00918Moderately InformativeInherited
Zebrafish Anatomy (ZA)surface structure0.7506InformativeInherited
Zebrafish Anatomy (ZA)epithelium0.6951Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)root system0.4785Least InformativeInherited
Plant ANatomical entity (PAN)leaf0.8409Least InformativeInherited
Plant ANatomical entity (PAN)root epidermis0.001718InformativeInherited
Plant ANatomical entity (PAN)adult vascular leaf0.0007043Highly InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorus-containing groups1Least InformativeInherited
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosylases0Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.00000000000003542Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0.0000002621Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.3707Moderately InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptidases)1Moderately InformativeInherited
Enzyme Commission (EC)RING-type E3 ubiquitin transferase0InformativeDirect
Enzyme Commission (EC)Hexosyltransferases0InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect
Enzyme Commission (EC)Metalloendopeptidases0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0.0000003409InformativeDirect
Enzyme Commission (EC)Serine endopeptidases1InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processDifferentiation0Moderately InformativeDirect
Biological processImmunity0Moderately InformativeDirect
Biological processUbl conjugation pathway0Moderately InformativeDirect
Biological processHost-virus interaction0Moderately InformativeDirect
Biological processApoptosis0.000000000001184Moderately InformativeDirect
Biological processVirulence0.00000000001557Moderately InformativeDirect
Biological processIon transport1Moderately InformativeInherited
Biological processAngiogenesis0InformativeDirect
Biological processAutophagy0InformativeDirect
Biological processCell adhesion0InformativeDirect
Biological processNeurogenesis0InformativeDirect
Biological processPolysaccharide degradation0InformativeDirect
Biological processVirus entry into host cell0InformativeDirect
Biological processCell wall biogenesis/degradation0.0000000000005449InformativeDirect
Biological processPlant defense0.000000000004543InformativeDirect
Biological processInnate immunity0.00000000003371InformativeDirect
Biological processHemostasis0.0001214InformativeDirect
Biological processAntiviral defense0Highly InformativeDirect
Biological processCalcium transport0.0000000000004478Highly InformativeDirect
Biological processAcute phase0.000000000001272Highly InformativeDirect
Biological processUnfolded protein response0.0000000001183Highly InformativeDirect
Biological processHearing0.000003188Highly InformativeDirect
Biological processBlood coagulation0.0001157Highly InformativeDirect
Biological processExocytosis0.0001401Highly InformativeDirect
Cellular componentMembrane0.00000000001493Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentVirion0Moderately InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentGolgi apparatus0.000003515Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.00001052Moderately InformativeDirect
Cellular componentCapsid protein0InformativeDirect
Cellular componentExtracellular matrix0InformativeDirect
Cellular componentVacuole0InformativeDirect
Cellular componentGPI-anchor0.000000000007326InformativeDirect
Cellular componentApoplast0Highly InformativeDirect
Cellular componentCell wall0Highly InformativeDirect
Cellular componentSarcoplasmic reticulum0Highly InformativeDirect
Cellular componentHost endoplasmic reticulum0Highly InformativeDirect
Coding sequence diversityAlternative splicing0.00001319Least InformativeDirect
Coding sequence diversityAlternative promoter usage0Moderately InformativeDirect
DiseaseDisease mutation0.00008728Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainRepeat0.00001861Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainCoiled coil0Moderately InformativeDirect
DomainZinc-finger0.000001258Moderately InformativeDirect
DomainEGF-like domain0InformativeDirect
DomainCollagen0Highly InformativeDirect
DomainLaminin EGF-like domain0Highly InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionMetal-binding0.0004285Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionManganese0.000000006728Moderately InformativeDirect
Molecular functionLipid-binding0.4123Moderately InformativeInherited
Molecular functionLectin0InformativeDirect
Molecular functionSteroid-binding0.00001676Highly InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationKinase1Moderately InformativeInherited
Post-translational modificationGlycosidase0InformativeDirect
Post-translational modificationHeparin-binding0InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0.00000001603InformativeDirect
Post-translational modificationToxin0.000004808InformativeDirect
Post-translational modificationCalmodulin-binding0.00003724InformativeDirect
Post-translational modificationIon channel0.0203InformativeInherited
Post-translational modificationHemagglutinin0Highly InformativeDirect
Post-translational modificationCalcium channel0.0000000000005139Highly InformativeDirect
Post-translational modificationLigand-gated ion channel0.000000006596Highly InformativeDirect
Post-translational modificationMitogen0.00002544Highly InformativeDirect
Post-translational modificationStorage protein0.002112Highly InformativeInherited
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationHydroxylation0InformativeDirect
Post-translational modificationProteoglycan0.0003301InformativeDirect
Post-translational modificationHeparan sulfate0.000000000968Highly InformativeDirect
Post-translational modificationPeptidoglycan-anchor0.00001126Highly InformativeDirect
Post-translational modificationGamma-carboxyglutamic acid0.0002873Highly InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR008985 SSF49899 Protein matches

Lectins and glucanases exhibit the common property of reversibly binding to specific complex carbohydrates. The lectins/glucanases are a diverse group of proteins found in a wide range of species from prokaryotes to humans. The different family members all contain a concanavalin A-like domain, which consists of a sandwich of 12-14 beta strands in two sheets with a complex topology. Members of this family are diverse, and include the lectins: legume lectins, cereal lectins, viral lectins, and animal lectins. Plant lectins function in the storage and transport of carbohydrates in seeds, the binding of nitrogen-fixing bacteria to root hairs, the inhibition of fungal growth or insect feeding, and in hormonally regulated plant growth [PubMed9094437]. Protein members include concanavalin A (Con A), favin, isolectin I, lectin IV, soybean agglutinin and lentil lectin. Animal lectins include the galectins, which are S-type lactose-binding and IgE-binding proteins such as S-lectin, CLC protein, galectin1, galectin2, galectin3 CRD, and Congerin I [PubMed11834744].

Other members with a Con A-like domain include the glucanases and xylanases. Bacterial and fungal beta-glucanases, such as Bacillus 1-3,1-4-beta-glucanse, carry out the acid catalysis of beta-glucans found in microorganisms and plants [PubMed7589539]. Similarly, kappa-Carrageenase degrades kappa-carrageenans from marine red algae cell walls [PubMed11435116]. Xylanase and cellobiohydrolase I degrade hemicellulose and cellulose, respectively [PubMed9618460, PubMed9466911].

There are many Con A-like domains found in proteins involved in cell recognition and adhesion. For example, several viral and bacterial toxins carry Con A-like domains. Examples include the Clostridium neurotoxins responsible for the neuroparalytic effects of botulism and tetanus [PubMed10932256]. The Pseudomonas exotoxin A, a virulence factor which is highly toxic to eukaryotic cells, causing the arrest of protein synthesis, contains a Con A-like domain involved in receptor binding [PubMed11734000]. Cholerae neuraminidase can bind to cell surfaces, possibly through their Con A-like domains, where they function as part of a mucinase complex to degrade the mucin layer of the gastrointestinal tract [PubMed7922030]. The rotaviral outer capsid protein, VP4, has a Con A-like sialic acid binding domain, which functions in cell attachment and membrane penetration [PubMed11867517].

Con A-like domains also play a role in cell recognition in eukaryotes. Proteins containing a Con A-like domain include the sex hormone-binding globulins which transport sex steroids in blood and regulate their access to target tissues [PubMed10675319], laminins which are large heterotrimeric glycoproteins involved in basement membrane architecture and function [PubMed10747011], neurexins which are expressed in hundreds of isoforms on the neuronal cell surface, where they may function as cell recognition molecules [PubMed10520997] and sialidases that are found in both microorganisms and animals, and function in cell adhesion and signal transduction [PubMed12419220].

Other proteins containing a Con A-like domain include pentraxins and calnexins. The pentraxin PTX3 is a TNFalpha-induced, secreted protein of adipose cells produced during inflammation [PubMed12611905]. The calnexin family of molecular chaperones is conserved among plants, fungi, and animals. Family members include Calnexin, a type-I integral membrane protein in the endoplasmic reticulum which coordinates the processing of newly synthesized N-linked glycoproteins with their productive folding, calmegin, a type-I membrane protein expressed mainly in the spermatids of the testis, and calreticulin, a soluble ER lumenal paralog [PubMed11583625].

InterPro database

PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 121 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Browse and view proteins in genomes which have different domain combinations including a Concanavalin A-like lectins/glucanases domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 121 hidden Markov models representing the Concanavalin A-like lectins/glucanases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]