SUPERFAMILY 1.75 HMM library and genome assignments server

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SH3-domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   SH3-like barrel [ 50036] (21)
Superfamily:   SH3-domain [ 50044]
Families:   SH3-domain [ 50045] (39)


Superfamily statistics
Genomes (733) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 39,669 100,597 127
Proteins 30,833 78,259 122


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0.00000007386 Least Informative Direct
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular component organization 0 Moderately Informative Direct
Biological Process (BP) single organism signaling 0 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0 Moderately Informative Direct
Biological Process (BP) regulation of localization 0 Moderately Informative Direct
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) cell communication 0 Moderately Informative Direct
Biological Process (BP) regulation of signaling 0.000000000002087 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.000000000002885 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 0.0000000004421 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 0.0000000008613 Moderately Informative Direct
Biological Process (BP) cellular component assembly 0.000000001797 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.00000002762 Moderately Informative Direct
Biological Process (BP) cellular localization 0.0000002635 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.000000344 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.0000009304 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.000005506 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.00001768 Moderately Informative Direct
Biological Process (BP) tissue development 0.0001244 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.0001478 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.0004154 Moderately Informative Direct
Biological Process (BP) single-organism transport 0.5472 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) protein complex biogenesis 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.01438 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.01993 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) animal organ development 0.838 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.007968 Moderately Informative Inherited
Biological Process (BP) nitrogen compound transport 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.1401 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) defense response 0.5553 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.0268 Moderately Informative Inherited
Biological Process (BP) reproduction 0.02509 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organophosphate biosynthetic process 0.5669 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) supramolecular fiber organization 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0 Informative Direct
Biological Process (BP) single-organism membrane organization 0 Informative Direct
Biological Process (BP) positive regulation of transport 0 Informative Direct
Biological Process (BP) vesicle-mediated transport 0 Informative Direct
Biological Process (BP) phosphorylation 0.000000000003123 Informative Direct
Biological Process (BP) actin cytoskeleton organization 0.00000000002571 Informative Direct
Biological Process (BP) cell development 0.00000000002758 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.00000000008961 Informative Direct
Biological Process (BP) epithelium development 0.000000001071 Informative Direct
Biological Process (BP) regulation of nervous system development 0.00000001231 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0.00000002188 Informative Direct
Biological Process (BP) regulation of growth 0.00000003359 Informative Direct
Biological Process (BP) regulation of protein modification process 0.00000004111 Informative Direct
Biological Process (BP) response to nitrogen compound 0.00000005015 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.0000004104 Informative Direct
Biological Process (BP) cell surface receptor signaling pathway 0.0000008864 Informative Direct
Biological Process (BP) cellular chemical homeostasis 0.000001029 Informative Direct
Biological Process (BP) regulation of intracellular signal transduction 0.000001277 Informative Direct
Biological Process (BP) regulation of locomotion 0.000002327 Informative Direct
Biological Process (BP) system process 0.000003442 Informative Direct
Biological Process (BP) positive regulation of cellular protein metabolic process 0.000008165 Informative Direct
Biological Process (BP) multi-organism reproductive process 0.00002692 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.00003183 Informative Direct
Biological Process (BP) behavior 0.00006223 Informative Direct
Biological Process (BP) growth 0.00006585 Informative Direct
Biological Process (BP) cellular response to hormone stimulus 0.0001104 Informative Direct
Biological Process (BP) response to wounding 0.0001213 Informative Direct
Biological Process (BP) regulation of hydrolase activity 0.0001308 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0.0001486 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0.0001759 Informative Direct
Biological Process (BP) intracellular signal transduction 0.0007929 Informative Direct
Biological Process (BP) cation homeostasis 0.0009319 Informative Direct
Biological Process (BP) positive regulation of immune system process 0.0009639 Informative Direct
Biological Process (BP) glycerolipid metabolic process 0.0009929 Informative Direct
Biological Process (BP) regulation of ion transport 1 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.02403 Informative Inherited
Biological Process (BP) regulation of protein localization 1 Informative Inherited
Biological Process (BP) regulation of peptide transport 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) regulation of cell differentiation 0.2584 Informative Inherited
Biological Process (BP) regulation of transmembrane transport 0.6254 Informative Inherited
Biological Process (BP) transmembrane transport 0.7546 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.001136 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 1 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.01508 Informative Inherited
Biological Process (BP) organelle assembly 0.003865 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.02071 Informative Inherited
Biological Process (BP) cellular protein complex assembly 0.155 Informative Inherited
Biological Process (BP) metal ion transport 0.002349 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.01865 Informative Inherited
Biological Process (BP) organelle localization 0.8804 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.8533 Informative Inherited
Biological Process (BP) intracellular transport 0.5219 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.04901 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.1822 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.04496 Informative Inherited
Biological Process (BP) regulation of transferase activity 1 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.5978 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.0357 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 1 Informative Inherited
Biological Process (BP) regulation of secretion 1 Informative Inherited
Biological Process (BP) regulation of cellular localization 1 Informative Inherited
Biological Process (BP) protein transport 0.2889 Informative Inherited
Biological Process (BP) generation of neurons 0.001304 Informative Inherited
Biological Process (BP) post-embryonic development 0.6285 Informative Inherited
Biological Process (BP) reproductive system development 1 Informative Inherited
Biological Process (BP) circulatory system development 0.1579 Informative Inherited
Biological Process (BP) immune response 0.09624 Informative Inherited
Biological Process (BP) pigment metabolic process 0.001414 Informative Inherited
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of gene expression 1 Informative Inherited
Biological Process (BP) regulation of phosphorylation 0.1502 Informative Inherited
Biological Process (BP) cell cycle process 1 Informative Inherited
Biological Process (BP) regulation of cell cycle 1 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) single-organism cellular localization 0.001157 Informative Inherited
Biological Process (BP) negative regulation of molecular function 1 Informative Inherited
Biological Process (BP) localization of cell 0.002654 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.9523 Informative Inherited
Biological Process (BP) inorganic ion homeostasis 0.00123 Informative Inherited
Biological Process (BP) phospholipid metabolic process 0.08514 Informative Inherited
Biological Process (BP) protein localization to organelle 1 Informative Inherited
Biological Process (BP) secondary metabolic process 0.08496 Informative Inherited
Biological Process (BP) embryo development 0.003321 Informative Inherited
Biological Process (BP) immune effector process 0.001746 Informative Inherited
Biological Process (BP) regulation of immune response 0.5846 Informative Inherited
Biological Process (BP) regulation of defense response 1 Informative Inherited
Biological Process (BP) regulation of cell proliferation 1 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.7799 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.02248 Informative Inherited
Biological Process (BP) regulation of vesicle-mediated transport 0.000000000000001925 Highly Informative Direct
Biological Process (BP) cell-cell signaling 0.000000000000003734 Highly Informative Direct
Biological Process (BP) regulation of cell shape 0.00000000000002769 Highly Informative Direct
Biological Process (BP) response to peptide hormone 0.00000000000003101 Highly Informative Direct
Biological Process (BP) divalent inorganic cation transport 0.0000000000004205 Highly Informative Direct
Biological Process (BP) regulation of GTPase activity 0.00000000001455 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 0.0000000000213 Highly Informative Direct
Biological Process (BP) regulation of protein polymerization 0.0000000001207 Highly Informative Direct
Biological Process (BP) cellular response to organonitrogen compound 0.0000000002223 Highly Informative Direct
Biological Process (BP) biological adhesion 0.0000000002514 Highly Informative Direct
Biological Process (BP) tube morphogenesis 0.0000000003895 Highly Informative Direct
Biological Process (BP) actin filament organization 0.000000001282 Highly Informative Direct
Biological Process (BP) endomembrane system organization 0.000000001934 Highly Informative Direct
Biological Process (BP) morphogenesis of an epithelium 0.00000000222 Highly Informative Direct
Biological Process (BP) female gamete generation 0.000000003726 Highly Informative Direct
Biological Process (BP) inorganic cation transmembrane transport 0.00000001195 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 0.00000008229 Highly Informative Direct
Biological Process (BP) small GTPase mediated signal transduction 0.0000004429 Highly Informative Direct
Biological Process (BP) regulation of ion homeostasis 0.0000006135 Highly Informative Direct
Biological Process (BP) regulation of actin polymerization or depolymerization 0.0000006468 Highly Informative Direct
Biological Process (BP) positive regulation of cellular component biogenesis 0.0000008454 Highly Informative Direct
Biological Process (BP) cell projection assembly 0.000003814 Highly Informative Direct
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.000006783 Highly Informative Direct
Biological Process (BP) positive regulation of cell development 0.000007157 Highly Informative Direct
Biological Process (BP) phagocytosis 0.000007714 Highly Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.00001207 Highly Informative Direct
Biological Process (BP) response to growth factor 0.00002334 Highly Informative Direct
Biological Process (BP) nucleotide-sugar metabolic process 0.000027 Highly Informative Direct
Biological Process (BP) negative regulation of supramolecular fiber organization 0.00002886 Highly Informative Direct
Biological Process (BP) cytokinesis 0.00004304 Highly Informative Direct
Biological Process (BP) phosphatidylinositol metabolic process 0.00006035 Highly Informative Direct
Biological Process (BP) positive regulation of nervous system development 0.00006065 Highly Informative Direct
Biological Process (BP) glycerophospholipid biosynthetic process 0.000122 Highly Informative Direct
Biological Process (BP) immune response-activating signal transduction 0.0001241 Highly Informative Direct
Biological Process (BP) neuron development 0.0001438 Highly Informative Direct
Biological Process (BP) negative regulation of homeostatic process 0.0001597 Highly Informative Direct
Biological Process (BP) regulation of leukocyte mediated immunity 0.0001598 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 0.0001742 Highly Informative Direct
Biological Process (BP) cellular component assembly involved in morphogenesis 0.0002101 Highly Informative Direct
Biological Process (BP) establishment of organelle localization 0.0002564 Highly Informative Direct
Biological Process (BP) negative regulation of growth 0.0003075 Highly Informative Direct
Biological Process (BP) multi-organism behavior 0.0003876 Highly Informative Direct
Biological Process (BP) wound healing 0.0004676 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 0.00077 Highly Informative Direct
Biological Process (BP) regulation of transmembrane transporter activity 0.2893 Highly Informative Inherited
Biological Process (BP) regulation of cation transmembrane transport 0.3562 Highly Informative Inherited
Biological Process (BP) positive regulation of apoptotic process 0.003643 Highly Informative Inherited
Biological Process (BP) regulation of apoptotic signaling pathway 0.5946 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 0.2572 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 1 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte migration 0.8696 Highly Informative Inherited
Biological Process (BP) regulation of protein complex disassembly 0.6671 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.001816 Highly Informative Inherited
Biological Process (BP) positive regulation of cell adhesion 0.01278 Highly Informative Inherited
Biological Process (BP) protein localization to membrane 0.08409 Highly Informative Inherited
Biological Process (BP) epithelial cell differentiation 0.006165 Highly Informative Inherited
Biological Process (BP) striated muscle cell development 1 Highly Informative Inherited
Biological Process (BP) single-organism behavior 0.03567 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.7874 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.008114 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 1 Highly Informative Inherited
Biological Process (BP) cellular calcium ion homeostasis 0.01033 Highly Informative Inherited
Biological Process (BP) gastrulation 1 Highly Informative Inherited
Biological Process (BP) cell proliferation 0.02317 Highly Informative Inherited
Biological Process (BP) muscle tissue development 1 Highly Informative Inherited
Biological Process (BP) heart development 0.1296 Highly Informative Inherited
Biological Process (BP) actomyosin structure organization 1 Highly Informative Inherited
Biological Process (BP) negative regulation of nervous system development 0.002137 Highly Informative Inherited
Biological Process (BP) MAPK cascade 0.01398 Highly Informative Inherited
Biological Process (BP) negative regulation of cytoskeleton organization 0.02567 Highly Informative Inherited
Biological Process (BP) negative regulation of protein complex assembly 0.001416 Highly Informative Inherited
Biological Process (BP) nervous system process 0.2726 Highly Informative Inherited
Biological Process (BP) appendage development 0.3987 Highly Informative Inherited
Biological Process (BP) sensory organ morphogenesis 0.0426 Highly Informative Inherited
Biological Process (BP) response to alcohol 0.6113 Highly Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.04455 Highly Informative Inherited
Biological Process (BP) regulation of MAP kinase activity 0.5979 Highly Informative Inherited
Biological Process (BP) positive regulation of MAPK cascade 1 Highly Informative Inherited
Biological Process (BP) positive regulation of protein serine/threonine kinase activity 1 Highly Informative Inherited
Biological Process (BP) positive regulation of immune effector process 0.8939 Highly Informative Inherited
Biological Process (BP) positive regulation of protein transport 1 Highly Informative Inherited
Biological Process (BP) regulation of nucleocytoplasmic transport 0.7031 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular protein localization 0.001247 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.9205 Highly Informative Inherited
Biological Process (BP) regulation of protein import 0.01725 Highly Informative Inherited
Biological Process (BP) regulation of intracellular protein transport 0.5275 Highly Informative Inherited
Biological Process (BP) regulation of protein localization to nucleus 0.5538 Highly Informative Inherited
Biological Process (BP) kidney development 0.01069 Highly Informative Inherited
Biological Process (BP) cytokine-mediated signaling pathway 1 Highly Informative Inherited
Biological Process (BP) post-embryonic animal morphogenesis 0.01834 Highly Informative Inherited
Biological Process (BP) negative regulation of phosphate metabolic process 0.7416 Highly Informative Inherited
Biological Process (BP) embryonic organ development 0.54 Highly Informative Inherited
Biological Process (BP) innate immune response 0.0771 Highly Informative Inherited
Biological Process (BP) developmental growth involved in morphogenesis 1 Highly Informative Inherited
Biological Process (BP) regulation of cell division 0.6015 Highly Informative Inherited
Biological Process (BP) positive regulation of lymphocyte activation 0.8438 Highly Informative Inherited
Biological Process (BP) germ cell development 0.1825 Highly Informative Inherited
Biological Process (BP) sex differentiation 0.9959 Highly Informative Inherited
Biological Process (BP) plasma membrane bounded cell projection organization 0.6668 Highly Informative Inherited
Biological Process (BP) second-messenger-mediated signaling 1 Highly Informative Inherited
Biological Process (BP) glycoprotein metabolic process 0.4026 Highly Informative Inherited
Biological Process (BP) protein import 0.5095 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.01954 Highly Informative Inherited
Biological Process (BP) camera-type eye development 1 Highly Informative Inherited
Biological Process (BP) transition metal ion homeostasis 0.933 Highly Informative Inherited
Biological Process (BP) protein targeting 0.01515 Highly Informative Inherited
Biological Process (BP) macromolecule glycosylation 0.06707 Highly Informative Inherited
Biological Process (BP) activation of innate immune response 1 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) transferase activity 0.01286 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) molecular function regulator 0 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.0000000000002355 Moderately Informative Direct
Molecular Function (MF) structural molecule activity 0.00000000009628 Moderately Informative Direct
Molecular Function (MF) anion binding 0.000003931 Moderately Informative Direct
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 1 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 1 Moderately Informative Inherited
Molecular Function (MF) transporter activity 0.8958 Moderately Informative Inherited
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0 Informative Direct
Molecular Function (MF) phospholipid binding 0 Informative Direct
Molecular Function (MF) enzyme binding 0.0000000000002201 Informative Direct
Molecular Function (MF) macromolecular complex binding 0.0000000000885 Informative Direct
Molecular Function (MF) passive transmembrane transporter activity 0.000000215 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 0.0000002383 Informative Direct
Molecular Function (MF) enzyme activator activity 0.000004536 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 1 Informative Inherited
Molecular Function (MF) ATPase activity 1 Informative Inherited
Molecular Function (MF) receptor binding 0.003022 Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 0.8659 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.8447 Informative Inherited
Molecular Function (MF) signal transducer activity 1 Informative Inherited
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0 Highly Informative Direct
Molecular Function (MF) GTPase regulator activity 0 Highly Informative Direct
Molecular Function (MF) phosphotransferase activity, phosphate group as acceptor 0 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0 Highly Informative Direct
Molecular Function (MF) nucleobase-containing compound kinase activity 0 Highly Informative Direct
Molecular Function (MF) cell adhesion molecule binding 0.000000000000007771 Highly Informative Direct
Molecular Function (MF) ion channel activity 0.000000008332 Highly Informative Direct
Molecular Function (MF) gated channel activity 0.000006933 Highly Informative Direct
Molecular Function (MF) kinase binding 0.0001806 Highly Informative Direct
Molecular Function (MF) phosphoric diester hydrolase activity 0.0009586 Highly Informative Direct
Molecular Function (MF) transferase activity, transferring hexosyl groups 0.1451 Highly Informative Inherited
Molecular Function (MF) protein transporter activity 0.0499 Highly Informative Inherited
Molecular Function (MF) kinase regulator activity 0.5261 Highly Informative Inherited
Molecular Function (MF) small GTPase binding 1 Highly Informative Inherited
Molecular Function (MF) protein kinase activity 0.4385 Highly Informative Inherited
Molecular Function (MF) lipase activity 0.0152 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 0 Least Informative Direct
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0.000000000003348 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) vesicle 0 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0 Moderately Informative Direct
Cellular Component (CC) whole membrane 0.8496 Moderately Informative Inherited
Cellular Component (CC) extracellular region part 0.4851 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) transferase complex 1 Moderately Informative Inherited
Cellular Component (CC) intrinsic component of membrane 1 Moderately Informative Inherited
Cellular Component (CC) bounding membrane of organelle 1 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 0.4058 Moderately Informative Inherited
Cellular Component (CC) plasma membrane region 0 Informative Direct
Cellular Component (CC) transporter complex 0 Informative Direct
Cellular Component (CC) apical part of cell 0 Informative Direct
Cellular Component (CC) supramolecular polymer 0 Informative Direct
Cellular Component (CC) actin cytoskeleton 0 Informative Direct
Cellular Component (CC) cytoplasmic region 0 Informative Direct
Cellular Component (CC) extrinsic component of membrane 0.0000001815 Informative Direct
Cellular Component (CC) membrane region 0.000001101 Informative Direct
Cellular Component (CC) extracellular organelle 0.0000322 Informative Direct
Cellular Component (CC) endosome 0.00004182 Informative Direct
Cellular Component (CC) cilium 0.0006107 Informative Direct
Cellular Component (CC) side of membrane 0.8202 Informative Inherited
Cellular Component (CC) cell surface 0.7273 Informative Inherited
Cellular Component (CC) extracellular space 1 Informative Inherited
Cellular Component (CC) plasma membrane bounded cell projection part 0.002015 Informative Inherited
Cellular Component (CC) oxidoreductase complex 0.4393 Informative Inherited
Cellular Component (CC) cytoplasmic vesicle part 0.7456 Informative Inherited
Cellular Component (CC) neuron projection 0.5675 Informative Inherited
Cellular Component (CC) transferase complex, transferring phosphorus-containing groups 0.9668 Informative Inherited
Cellular Component (CC) microbody 0.5492 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) cell division site part 0 Highly Informative Direct
Cellular Component (CC) ruffle 0 Highly Informative Direct
Cellular Component (CC) cortical cytoskeleton 0.000000000007442 Highly Informative Direct
Cellular Component (CC) extrinsic component of cytoplasmic side of plasma membrane 0.000000009646 Highly Informative Direct
Cellular Component (CC) midbody 0.00000001115 Highly Informative Direct
Cellular Component (CC) extracellular exosome 0.0000005636 Highly Informative Direct
Cellular Component (CC) exocytic vesicle 0.00003526 Highly Informative Direct
Cellular Component (CC) contractile ring 0.0002336 Highly Informative Direct
Cellular Component (CC) presynapse 0.003977 Highly Informative Inherited
Cellular Component (CC) intrinsic component of plasma membrane 1 Highly Informative Inherited
Cellular Component (CC) microtubule organizing center 1 Highly Informative Inherited
Cellular Component (CC) sarcomere 0.004727 Highly Informative Inherited
Cellular Component (CC) receptor complex 0.02474 Highly Informative Inherited
Cellular Component (CC) cell-cell junction 0.5455 Highly Informative Inherited
Cellular Component (CC) microbody membrane 0.00106 Highly Informative Inherited
Cellular Component (CC) peroxisomal part 0.001625 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0.4052Least InformativeInherited
Enzyme Commission (EC)Phosphoric diester hydrolases0.00000006272Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.0001767Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Phosphoinositide phospholipase C0.000000000000003251InformativeDirect
Enzyme Commission (EC)Mitogen-activated protein kinase kinase kinase0.0000000000002472Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.397Least InformativeInherited
Biological processImmunity0Moderately InformativeDirect
Biological processProtein transport0Moderately InformativeDirect
Biological processApoptosis0.000000001204Moderately InformativeDirect
Biological processDifferentiation0.000000001205Moderately InformativeDirect
Biological processCell cycle0.0006099Moderately InformativeDirect
Biological processIon transport0.6884Moderately InformativeInherited
Biological processEndocytosis0InformativeDirect
Biological processStress response0InformativeDirect
Biological processCell adhesion0.00000000001928InformativeDirect
Biological processNeurogenesis0.0000000003314InformativeDirect
Biological processMitosis0.000000003196InformativeDirect
Biological processInflammatory response0.00001193InformativeDirect
Biological processAutophagy0.0003198InformativeDirect
Biological processCalcium transport0Highly InformativeDirect
Biological processPhagocytosis0.0000000000003061Highly InformativeDirect
Biological processAdaptive immunity0.0000000002226Highly InformativeDirect
Biological processCilium biogenesis/degradation0.0000000006152Highly InformativeDirect
Biological processExocytosis0.0000007489Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentGolgi apparatus0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentEndosome0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0Moderately InformativeDirect
Cellular componentCell membrane0.00000001976Moderately InformativeDirect
Cellular componentLysosome0.00001182InformativeDirect
Cellular componentCoated pit0Highly InformativeDirect
Coding sequence diversityAlternative splicing0.000000000766Least InformativeDirect
Coding sequence diversityChromosomal rearrangement0.0000977InformativeDirect
DiseaseProto-oncogene0Moderately InformativeDirect
DomainRepeat0.0000958Least InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
DomainSH2 domain0InformativeDirect
DomainSH3 domain0InformativeDirect
DomainSH3-binding0InformativeDirect
DomainANK repeat0.000000005656InformativeDirect
Molecular functionLipid-binding0Moderately InformativeDirect
Molecular functionCalcium0.000001874Moderately InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0.00000005186Moderately InformativeDirect
Post-translational modificationActin-binding0InformativeDirect
Post-translational modificationCalmodulin-binding0InformativeDirect
Post-translational modificationGTPase activation0InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor0InformativeDirect
Post-translational modificationIon channel0.000002179InformativeDirect
Post-translational modificationCalcium channel0Highly InformativeDirect
Post-translational modificationMyosin0Highly InformativeDirect
Post-translational modificationTyrosine-protein kinase0Highly InformativeDirect
Post-translational modificationVoltage-gated channel0.000000000000132Highly InformativeDirect
Post-translational modificationActin capping0.0000000132Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationMyristate0InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR001452 SSF50044 Protein matches
Abstract SH3 (src Homology-3) domains are small protein modules containing approximately 50 amino acid residues [PubMed15335710, PubMed11256992]. They are found in a great variety of intracellular or membrane-associated proteins [PubMed1639195, PubMed14731533, PubMed7531822] for example, in a variety of proteins with enzymatic activity, in adaptor proteins that lack catalytic sequences and in cytoskeletal proteins, such as fodrin and yeast actin binding protein ABP-1.

The SH3 domain has a characteristic fold which consists of five or six beta-strands arranged as two tightly packed anti-parallel beta sheets. The linker regions may contain short helices. The surface of the SH2-domain bears a flat, hydrophobic ligand-binding pocket which consists of three shallow grooves defined by conservative aromatic residues in which the ligand adopts an extended left-handed helical arrangement. The ligand binds with low affinity but this may be enhanced by multiple interactions. The region bound by the SH3 domain is in all cases proline-rich and contains PXXP as a core-conserved binding motif. The function of the SH3 domain is not well understood but they may mediate many diverse processes such as increasing local concentration of proteins, altering their subcellular location and mediating the assembly of large multiprotein complexes [PubMed7953536].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 58 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a SH3-domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 58 hidden Markov models representing the SH3-domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]