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SH3-domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   SH3-like barrel [ 50036] (21)
Superfamily:   SH3-domain [ 50044]
Families:   SH3-domain [ 50045] (39)


Superfamily statistics
Genomes (726) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 38,756 44,557 127
Proteins 30,125 34,695 122


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) response to stimulus 0.00000003361 Least Informative Direct
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cell communication 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0 Moderately Informative Direct
Biological Process (BP) regulation of localization 0 Moderately Informative Direct
Biological Process (BP) cellular developmental process 0 Moderately Informative Direct
Biological Process (BP) signaling 0 Moderately Informative Direct
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) cellular component assembly 0.0000000000001098 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.0000000003927 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 0.0000000007375 Moderately Informative Direct
Biological Process (BP) regulation of signaling 0.000000001433 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.000000008318 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.00000001269 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.00000008155 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 0.0000002111 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.0000003131 Moderately Informative Direct
Biological Process (BP) cellular localization 0.0000007315 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.00008476 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.0006028 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.0006379 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.08484 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) response to stress 1 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.3738 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.04126 Moderately Informative Inherited
Biological Process (BP) reproduction 0.05535 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) system development 0.221 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.06296 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organophosphate biosynthetic process 0.4336 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cytoskeleton organization 0 Informative Direct
Biological Process (BP) positive regulation of transport 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0 Informative Direct
Biological Process (BP) actin filament-based process 0 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0 Informative Direct
Biological Process (BP) cell adhesion 0 Informative Direct
Biological Process (BP) single-organism membrane organization 0 Informative Direct
Biological Process (BP) vesicle-mediated transport 0 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0.000000000029 Informative Direct
Biological Process (BP) phosphorylation 0.0000000002343 Informative Direct
Biological Process (BP) cell development 0.0000000003583 Informative Direct
Biological Process (BP) response to nitrogen compound 0.000000001815 Informative Direct
Biological Process (BP) epithelium development 0.000000002747 Informative Direct
Biological Process (BP) regulation of nervous system development 0.00000001683 Informative Direct
Biological Process (BP) generation of neurons 0.00000003567 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.0000001185 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.0000001641 Informative Direct
Biological Process (BP) regulation of growth 0.0000002107 Informative Direct
Biological Process (BP) cell surface receptor signaling pathway 0.0000005231 Informative Direct
Biological Process (BP) regulation of protein modification process 0.0000006535 Informative Direct
Biological Process (BP) behavior 0.000001434 Informative Direct
Biological Process (BP) positive regulation of cellular protein metabolic process 0.000002525 Informative Direct
Biological Process (BP) cellular chemical homeostasis 0.000002539 Informative Direct
Biological Process (BP) cellular response to hormone stimulus 0.00000979 Informative Direct
Biological Process (BP) regulation of intracellular signal transduction 0.00001162 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0.000025 Informative Direct
Biological Process (BP) regulation of locomotion 0.00007513 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0.00009883 Informative Direct
Biological Process (BP) system process 0.0001742 Informative Direct
Biological Process (BP) positive regulation of cell death 0.0002892 Informative Direct
Biological Process (BP) glycerolipid metabolic process 0.0002983 Informative Direct
Biological Process (BP) regulation of hydrolase activity 0.0003045 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.0003332 Informative Direct
Biological Process (BP) multi-organism reproductive process 0.0004423 Informative Direct
Biological Process (BP) pigment metabolic process 0.0008179 Informative Direct
Biological Process (BP) regulation of apoptotic process 0.03232 Informative Inherited
Biological Process (BP) regulation of cell proliferation 1 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) regulation of cellular localization 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.1188 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.2764 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.009652 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 1 Informative Inherited
Biological Process (BP) regulation of protein localization 1 Informative Inherited
Biological Process (BP) protein localization to organelle 1 Informative Inherited
Biological Process (BP) response to organic cyclic compound 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.03775 Informative Inherited
Biological Process (BP) organelle assembly 0.001588 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 0.3372 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.004932 Informative Inherited
Biological Process (BP) circulatory system development 0.164 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.008817 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) transmembrane transport 0.6429 Informative Inherited
Biological Process (BP) growth 0.004053 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 1 Informative Inherited
Biological Process (BP) regulation of phosphorylation 0.2267 Informative Inherited
Biological Process (BP) reproductive system development 1 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.8696 Informative Inherited
Biological Process (BP) negative regulation of transport 1 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.06395 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.4412 Informative Inherited
Biological Process (BP) regulation of transferase activity 1 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.1232 Informative Inherited
Biological Process (BP) regulation of secretion 1 Informative Inherited
Biological Process (BP) regulation of immune response 0.7378 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.06234 Informative Inherited
Biological Process (BP) single-organism intracellular transport 0.005474 Informative Inherited
Biological Process (BP) post-embryonic development 0.5948 Informative Inherited
Biological Process (BP) secondary metabolic process 0.06664 Informative Inherited
Biological Process (BP) immune response 0.1015 Informative Inherited
Biological Process (BP) regulation of transmembrane transport 0.6113 Informative Inherited
Biological Process (BP) regulation of ion transport 1 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of gene expression 1 Informative Inherited
Biological Process (BP) cell cycle process 0.894 Informative Inherited
Biological Process (BP) regulation of cell differentiation 0.2316 Informative Inherited
Biological Process (BP) central nervous system development 0.7243 Informative Inherited
Biological Process (BP) protein targeting 0.6912 Informative Inherited
Biological Process (BP) embryo development 0.006717 Informative Inherited
Biological Process (BP) negative regulation of molecular function 1 Informative Inherited
Biological Process (BP) phospholipid metabolic process 0.03984 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.001916 Informative Inherited
Biological Process (BP) ion homeostasis 0.6494 Informative Inherited
Biological Process (BP) metal ion transport 0.001374 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.001211 Informative Inherited
Biological Process (BP) regulation of defense response 1 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.8087 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.004285 Informative Inherited
Biological Process (BP) actin filament organization 0 Highly Informative Direct
Biological Process (BP) cell junction assembly 0 Highly Informative Direct
Biological Process (BP) cell projection organization 0 Highly Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 0.000000000000001902 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.000000000000001902 Highly Informative Direct
Biological Process (BP) response to peptide hormone 0.00000000000005973 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 0.0000000000001526 Highly Informative Direct
Biological Process (BP) cellular response to organonitrogen compound 0.00000000001926 Highly Informative Direct
Biological Process (BP) regulation of cell shape 0.00000000002282 Highly Informative Direct
Biological Process (BP) divalent inorganic cation transport 0.0000000006774 Highly Informative Direct
Biological Process (BP) endomembrane system organization 0.000000002277 Highly Informative Direct
Biological Process (BP) tube morphogenesis 0.000000002966 Highly Informative Direct
Biological Process (BP) muscle structure development 0.000000003082 Highly Informative Direct
Biological Process (BP) female gamete generation 0.00000001152 Highly Informative Direct
Biological Process (BP) morphogenesis of an epithelium 0.00000004113 Highly Informative Direct
Biological Process (BP) small GTPase mediated signal transduction 0.00000007161 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 0.0000001067 Highly Informative Direct
Biological Process (BP) cell division 0.0000006036 Highly Informative Direct
Biological Process (BP) regulation of ion homeostasis 0.0000009638 Highly Informative Direct
Biological Process (BP) reactive oxygen species metabolic process 0.00000419 Highly Informative Direct
Biological Process (BP) cellular component assembly involved in morphogenesis 0.00001057 Highly Informative Direct
Biological Process (BP) inorganic cation transmembrane transport 0.0000112 Highly Informative Direct
Biological Process (BP) regulation of actin filament polymerization 0.00001147 Highly Informative Direct
Biological Process (BP) nucleotide-sugar metabolic process 0.00001347 Highly Informative Direct
Biological Process (BP) positive regulation of cell development 0.00002959 Highly Informative Direct
Biological Process (BP) positive regulation of cellular component biogenesis 0.00003198 Highly Informative Direct
Biological Process (BP) glycerophospholipid biosynthetic process 0.00005593 Highly Informative Direct
Biological Process (BP) positive regulation of GTPase activity 0.00005947 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 0.00007502 Highly Informative Direct
Biological Process (BP) phosphatidylinositol metabolic process 0.00008789 Highly Informative Direct
Biological Process (BP) negative regulation of homeostatic process 0.00009102 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 0.00009688 Highly Informative Direct
Biological Process (BP) vesicle localization 0.0001315 Highly Informative Direct
Biological Process (BP) epithelial cell differentiation 0.0001993 Highly Informative Direct
Biological Process (BP) multi-organism behavior 0.0002079 Highly Informative Direct
Biological Process (BP) wound healing 0.0002717 Highly Informative Direct
Biological Process (BP) chemotaxis 0.0002776 Highly Informative Direct
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.0002978 Highly Informative Direct
Biological Process (BP) negative regulation of growth 0.0003101 Highly Informative Direct
Biological Process (BP) positive regulation of nervous system development 0.0003134 Highly Informative Direct
Biological Process (BP) endocytosis 0.0004193 Highly Informative Direct
Biological Process (BP) establishment of organelle localization 0.0007866 Highly Informative Direct
Biological Process (BP) positive regulation of apoptotic process 0.006826 Highly Informative Inherited
Biological Process (BP) regulation of apoptotic signaling pathway 0.5266 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 0.3791 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane transporter activity 0.4144 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 1 Highly Informative Inherited
Biological Process (BP) regulation of protein complex disassembly 0.2357 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.7334 Highly Informative Inherited
Biological Process (BP) positive regulation of cell adhesion 0.02415 Highly Informative Inherited
Biological Process (BP) renal system process 0.8188 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte migration 0.7423 Highly Informative Inherited
Biological Process (BP) actomyosin structure organization 1 Highly Informative Inherited
Biological Process (BP) inner ear development 0.002418 Highly Informative Inherited
Biological Process (BP) pattern specification process 1 Highly Informative Inherited
Biological Process (BP) leukocyte cell-cell adhesion 0.9633 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.02937 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 1 Highly Informative Inherited
Biological Process (BP) neuron development 0.01593 Highly Informative Inherited
Biological Process (BP) cell proliferation 0.008932 Highly Informative Inherited
Biological Process (BP) MAPK cascade 0.02536 Highly Informative Inherited
Biological Process (BP) cellular calcium ion homeostasis 0.008388 Highly Informative Inherited
Biological Process (BP) negative regulation of cytoskeleton organization 0.06894 Highly Informative Inherited
Biological Process (BP) negative regulation of protein polymerization 0.4436 Highly Informative Inherited
Biological Process (BP) sensory perception 1 Highly Informative Inherited
Biological Process (BP) sex differentiation 0.8662 Highly Informative Inherited
Biological Process (BP) appendage development 0.3618 Highly Informative Inherited
Biological Process (BP) germ cell development 0.2536 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 0.05223 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.009868 Highly Informative Inherited
Biological Process (BP) response to alcohol 0.4609 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte mediated immunity 0.004816 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular protein localization 0.001764 Highly Informative Inherited
Biological Process (BP) regulation of protein import into nucleus 0.3687 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 1 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.5816 Highly Informative Inherited
Biological Process (BP) metamorphosis 0.01352 Highly Informative Inherited
Biological Process (BP) instar larval or pupal morphogenesis 0.01507 Highly Informative Inherited
Biological Process (BP) negative regulation of phosphate metabolic process 0.7505 Highly Informative Inherited
Biological Process (BP) innate immune response 0.03392 Highly Informative Inherited
Biological Process (BP) developmental growth involved in morphogenesis 1 Highly Informative Inherited
Biological Process (BP) positive regulation of immune effector process 1 Highly Informative Inherited
Biological Process (BP) brain development 0.3088 Highly Informative Inherited
Biological Process (BP) glycoprotein metabolic process 0.217 Highly Informative Inherited
Biological Process (BP) protein import 0.4684 Highly Informative Inherited
Biological Process (BP) camera-type eye development 1 Highly Informative Inherited
Biological Process (BP) sensory organ morphogenesis 0.1485 Highly Informative Inherited
Biological Process (BP) endosomal transport 0.001501 Highly Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 1 Highly Informative Inherited
Biological Process (BP) single-organism behavior 0.005865 Highly Informative Inherited
Biological Process (BP) cell migration 0.08856 Highly Informative Inherited
Biological Process (BP) synaptic signaling 0.1253 Highly Informative Inherited
Biological Process (BP) transition metal ion homeostasis 0.9172 Highly Informative Inherited
Biological Process (BP) macromolecule glycosylation 0.05218 Highly Informative Inherited
Biological Process (BP) innate immune response-activating signal transduction 1 Highly Informative Inherited
Biological Process (BP) gastrulation 1 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity 0.004161 Least Informative Inherited
Molecular Function (MF) molecular function regulator 0 Moderately Informative Direct
Molecular Function (MF) protein binding 0 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.0000000000000672 Moderately Informative Direct
Molecular Function (MF) structural molecule activity 0.00000000008436 Moderately Informative Direct
Molecular Function (MF) anion binding 0.0000008506 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 1 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 1 Moderately Informative Inherited
Molecular Function (MF) phospholipid binding 0 Informative Direct
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0.000000000000004807 Informative Direct
Molecular Function (MF) enzyme binding 0.0000000001534 Informative Direct
Molecular Function (MF) enzyme activator activity 0.00001048 Informative Direct
Molecular Function (MF) passive transmembrane transporter activity 0.0002391 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 0.0003047 Informative Direct
Molecular Function (MF) macromolecular complex binding 0.0009511 Informative Direct
Molecular Function (MF) transferase activity, transferring glycosyl groups 0.8317 Informative Inherited
Molecular Function (MF) receptor binding 0.01386 Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 1 Informative Inherited
Molecular Function (MF) ATPase activity 1 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.7568 Informative Inherited
Molecular Function (MF) signal transducer activity 1 Informative Inherited
Molecular Function (MF) phosphoric ester hydrolase activity 0.1908 Informative Inherited
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0 Highly Informative Direct
Molecular Function (MF) phosphotransferase activity, phosphate group as acceptor 0 Highly Informative Direct
Molecular Function (MF) GTPase regulator activity 0 Highly Informative Direct
Molecular Function (MF) nucleobase-containing compound kinase activity 0.000000000000001646 Highly Informative Direct
Molecular Function (MF) ion channel activity 0.00002385 Highly Informative Direct
Molecular Function (MF) gated channel activity 0.00002547 Highly Informative Direct
Molecular Function (MF) phospholipase activity 0.0001139 Highly Informative Direct
Molecular Function (MF) phosphoric diester hydrolase activity 0.0004791 Highly Informative Direct
Molecular Function (MF) kinase binding 0.000662 Highly Informative Direct
Molecular Function (MF) small GTPase binding 1 Highly Informative Inherited
Molecular Function (MF) transferase activity, transferring hexosyl groups 0.09933 Highly Informative Inherited
Molecular Function (MF) protein kinase activity 0.6055 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.0000000000004268 Least Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0.0000000108 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) vesicle 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0 Moderately Informative Direct
Cellular Component (CC) endoplasmic reticulum 1 Moderately Informative Inherited
Cellular Component (CC) extracellular region part 0.4422 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) transferase complex 1 Moderately Informative Inherited
Cellular Component (CC) intrinsic component of membrane 1 Moderately Informative Inherited
Cellular Component (CC) whole membrane 0.6761 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.691 Moderately Informative Inherited
Cellular Component (CC) apical part of cell 0 Informative Direct
Cellular Component (CC) plasma membrane region 0 Informative Direct
Cellular Component (CC) cell projection part 0 Informative Direct
Cellular Component (CC) actin cytoskeleton 0 Informative Direct
Cellular Component (CC) cell junction 0 Informative Direct
Cellular Component (CC) cytoplasmic region 0 Informative Direct
Cellular Component (CC) synapse 0 Informative Direct
Cellular Component (CC) site of polarized growth 0 Informative Direct
Cellular Component (CC) transporter complex 0.0000000000000175 Informative Direct
Cellular Component (CC) extrinsic component of membrane 0.000000004122 Informative Direct
Cellular Component (CC) extracellular organelle 0.000006929 Informative Direct
Cellular Component (CC) membrane region 0.00002183 Informative Direct
Cellular Component (CC) endosome 0.00007501 Informative Direct
Cellular Component (CC) cilium 0.0007439 Informative Direct
Cellular Component (CC) side of membrane 0.1259 Informative Inherited
Cellular Component (CC) cell surface 1 Informative Inherited
Cellular Component (CC) neuron projection 0.3555 Informative Inherited
Cellular Component (CC) transport vesicle 0.182 Informative Inherited
Cellular Component (CC) secretory vesicle 1 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) oxidoreductase complex 0.3036 Informative Inherited
Cellular Component (CC) cytoplasmic vesicle part 0.7468 Informative Inherited
Cellular Component (CC) microbody 0.3689 Informative Inherited
Cellular Component (CC) ruffle 0 Highly Informative Direct
Cellular Component (CC) cell division site 0.00000000000003133 Highly Informative Direct
Cellular Component (CC) contractile fiber part 0.000000000003111 Highly Informative Direct
Cellular Component (CC) cortical cytoskeleton 0.00000000000933 Highly Informative Direct
Cellular Component (CC) extrinsic component of cytoplasmic side of plasma membrane 0.000000004346 Highly Informative Direct
Cellular Component (CC) extracellular exosome 0.0000003264 Highly Informative Direct
Cellular Component (CC) anchoring junction 0.0000009177 Highly Informative Direct
Cellular Component (CC) midbody 0.0000038 Highly Informative Direct
Cellular Component (CC) apical plasma membrane 0.0003942 Highly Informative Direct
Cellular Component (CC) microbody membrane 0.0004837 Highly Informative Direct
Cellular Component (CC) peroxisomal part 0.0007582 Highly Informative Direct
Cellular Component (CC) receptor complex 0.009274 Highly Informative Inherited
Cellular Component (CC) myofibril 0.002358 Highly Informative Inherited
Cellular Component (CC) intrinsic component of plasma membrane 1 Highly Informative Inherited
Cellular Component (CC) cell-cell junction 0.3453 Highly Informative Inherited
Cellular Component (CC) centrosome 0.02146 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0.4052Least InformativeInherited
Enzyme Commission (EC)Phosphoric diester hydrolases0.00000006272Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.0001767Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Phosphoinositide phospholipase C0.000000000000003251InformativeDirect
Enzyme Commission (EC)Mitogen-activated protein kinase kinase kinase0.0000000000002472Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the face0.2824Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the immune system0.2889Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.4067Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.57Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.8191Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.1685Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.2354Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal inflammatory response0.2873Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the oral cavity0.3505Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.4612Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cell physiology0.07041InformativeInherited
Phenotypic Abnormality (PA)Abnormality of oral mucosa0.1107InformativeInherited
Phenotypic Abnormality (PA)Recurrent infections0.1511InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lymphatic system0.1639InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal physiology0.2053InformativeInherited
Phenotypic Abnormality (PA)Abnormality of bone marrow cell morphology0.5725InformativeInherited
Phenotypic Abnormality (PA)Cellulitis0.000002622Highly InformativeDirect
Phenotypic Abnormality (PA)Recurrent aphthous stomatitis0.0000286Highly InformativeDirect
Phenotypic Abnormality (PA)Osteomyelitis0.0002115Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of neutrophils0.06188Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype0.01685Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.03276Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.08Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.6882Least InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.06987Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.09352Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.09713Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.1441Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.2606Moderately InformativeInherited
Mammalian Phenotype (MP)hearing/vestibular/ear phenotype0.2739Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.6235Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.816Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.8492Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.8652Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.9653Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal B cell proliferation0.000319InformativeDirect
Mammalian Phenotype (MP)abnormal neuron physiology0.2693InformativeInherited
Mammalian Phenotype (MP)abnormal enzyme/coenzyme activity0.2941InformativeInherited
Mammalian Phenotype (MP)abnormal CNS synaptic transmission0.3371InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin secretion0.3857InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear hair cell morphology0.3864InformativeInherited
Mammalian Phenotype (MP)abnormal T cell differentiation0.441InformativeInherited
Mammalian Phenotype (MP)abnormal effector T cell morphology0.4784InformativeInherited
Mammalian Phenotype (MP)abnormal alpha-beta T cell morphology0.5392InformativeInherited
Mammalian Phenotype (MP)abnormal synaptic vesicle recycling0.000005806Highly InformativeDirect
Mammalian Phenotype (MP)decreased excitatory postsynaptic current amplitude0.0004475Highly InformativeDirect
Mammalian Phenotype (MP)abnormal interleukin-2 secretion0.0004486Highly InformativeDirect
Mammalian Phenotype (MP)abnormal granulocyte physiology0.05894Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear hair cell stereociliary bundle morphology0.08719Highly InformativeInherited
Mammalian Phenotype (MP)abnormal CD8-positive, alpha beta T cell morphology0.2765Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell morphology variant0.001074Least InformativeInherited
Worm Phenotype (WP)organ system morphology variant0.002511Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.006207Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.009213Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.01904Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.2093Least InformativeInherited
Worm Phenotype (WP)apoptosis variant0.00003386Moderately InformativeDirect
Worm Phenotype (WP)chemical response variant0.04321Moderately InformativeInherited
Worm Phenotype (WP)germ cell morphology variant0.437Moderately InformativeInherited
Worm Phenotype (WP)cell component morphology variant0.5604Moderately InformativeInherited
Worm Phenotype (WP)aldicarb response variant0.00005818InformativeDirect
Worm Phenotype (WP)muscle system morphology variant0.06916InformativeInherited
Worm Phenotype (WP)organelle organization biogenesis variant0.1627InformativeInherited
Worm Phenotype (WP)protein modification variant0.1723InformativeInherited
Worm Phenotype (WP)pattern protein expression variant0.2287InformativeInherited
Worm Phenotype (WP)oocyte morphology variant0.927InformativeInherited
Worm Phenotype (WP)body elongation variant0.0002132Highly InformativeDirect
Worm Phenotype (WP)endomitotic oocytes0.0003961Highly InformativeDirect
Worm Phenotype (WP)protein phosphorylation variant0.0004219Highly InformativeDirect
Worm Phenotype (WP)ovulation variant0.0004994Highly InformativeDirect
Worm Phenotype (WP)protein subcellular localization variant0.000768Highly InformativeDirect
Worm Phenotype (WP)cytoskeleton organization biogenesis variant0.03986Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)morphology0.1477Moderately InformativeInherited
Yeast Phenotype (YP)intracellular transport0.00001994InformativeDirect
Yeast Phenotype (YP)subcellular morphology0.3142InformativeInherited
Yeast Phenotype (YP)chitin deposition0.0003555Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)nervous system0.08496Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.154Least InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.005516Moderately InformativeInherited
Fly Anatomy (FA)cell component0.0003234InformativeDirect
Fly Anatomy (FA)neuromuscular junction0.0004394Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)portion of meristem tissue0Least InformativeDirect
Plant ANatomical entity (PAN)megasporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)sporangium0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence meristem0Moderately InformativeDirect
Plant ANatomical entity (PAN)cotyledon0Moderately InformativeDirect
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.12 twelve leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.08 eight leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.02 two leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0.0003717Moderately InformativeDirect
Enzyme Commission (EC)Transferring one-carbon groups1Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0.000000006026InformativeDirect
Enzyme Commission (EC)Hexosyltransferases0.00002106InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0Highly InformativeDirect
Enzyme Commission (EC)Phosphoinositide phospholipase C0Highly InformativeDirect

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)antineoplastic and immunomodulating agents0.00004588Least InformativeDirect
Drugbank ATC_code (DB)cardiovascular system0.05369Least InformativeInherited
Drugbank ATC_code (DB)protein kinase inhibitors0.0000000000002985Moderately InformativeDirect
Drugbank ATC_code (DB)cardiac therapy0.004264Moderately InformativeInherited
Drugbank ATC_code (DB)aldosterone antagonists0.000008291InformativeDirect
Drugbank ATC_code (DB)dihydropyridine derivatives0.00004656InformativeDirect
Drugbank ATC_code (DB)antiarrhythmics, class iii0.0002499InformativeDirect
Drugbank ATC_code (DB)opium alkaloids and derivatives0.0007748InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.3568Least InformativeInherited
Biological processImmunity0Moderately InformativeDirect
Biological processProtein transport0Moderately InformativeDirect
Biological processDifferentiation0.0000000005998Moderately InformativeDirect
Biological processApoptosis0.000000000996Moderately InformativeDirect
Biological processCell cycle0.0005165Moderately InformativeDirect
Biological processIon transport0.6923Moderately InformativeInherited
Biological processEndocytosis0InformativeDirect
Biological processStress response0InformativeDirect
Biological processCell adhesion0.00000000001539InformativeDirect
Biological processNeurogenesis0.0000000002275InformativeDirect
Biological processMitosis0.000000001689InformativeDirect
Biological processInflammatory response0.00001121InformativeDirect
Biological processAutophagy0.000275InformativeDirect
Biological processCalcium transport0Highly InformativeDirect
Biological processPhagocytosis0.0000000000002693Highly InformativeDirect
Biological processAdaptive immunity0.000000000004728Highly InformativeDirect
Biological processCilium biogenesis/degradation0.0000000002871Highly InformativeDirect
Biological processExocytosis0.0000006737Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentGolgi apparatus0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentEndosome0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0Moderately InformativeDirect
Cellular componentCell membrane0.00000003577Moderately InformativeDirect
Cellular componentLysosome0.000005022InformativeDirect
Cellular componentCoated pit0Highly InformativeDirect
Coding sequence diversityAlternative splicing0.0000000009857Least InformativeDirect
Coding sequence diversityChromosomal rearrangement0.00009779InformativeDirect
DiseaseProto-oncogene0Moderately InformativeDirect
DomainRepeat0.0001113Least InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
DomainSH2 domain0InformativeDirect
DomainSH3 domain0InformativeDirect
DomainSH3-binding0InformativeDirect
DomainANK repeat0.00000001505InformativeDirect
Molecular functionLipid-binding0Moderately InformativeDirect
Molecular functionCalcium0.000001294Moderately InformativeDirect
Molecular functionActin-binding0InformativeDirect
Molecular functionCalmodulin-binding0InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0.0000007673Moderately InformativeDirect
Post-translational modificationGTPase activation0InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor0InformativeDirect
Post-translational modificationIon channel0.000001983InformativeDirect
Post-translational modificationCalcium channel0Highly InformativeDirect
Post-translational modificationMyosin0Highly InformativeDirect
Post-translational modificationTyrosine-protein kinase0Highly InformativeDirect
Post-translational modificationVoltage-gated channel0.0000000000001064Highly InformativeDirect
Post-translational modificationActin capping0.00000001319Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation0.000431Moderately InformativeDirect
Post-translational modificationMyristate0InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein glycosylation0.0000145InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR001452 SSF50044 Protein matches
Abstract SH3 (src Homology-3) domains are small protein modules containing approximately 50 amino acid residues [PubMed15335710, PubMed11256992]. They are found in a great variety of intracellular or membrane-associated proteins [PubMed1639195, PubMed14731533, PubMed7531822] for example, in a variety of proteins with enzymatic activity, in adaptor proteins that lack catalytic sequences and in cytoskeletal proteins, such as fodrin and yeast actin binding protein ABP-1.

The SH3 domain has a characteristic fold which consists of five or six beta-strands arranged as two tightly packed anti-parallel beta sheets. The linker regions may contain short helices. The surface of the SH2-domain bears a flat, hydrophobic ligand-binding pocket which consists of three shallow grooves defined by conservative aromatic residues in which the ligand adopts an extended left-handed helical arrangement. The ligand binds with low affinity but this may be enhanced by multiple interactions. The region bound by the SH3 domain is in all cases proline-rich and contains PXXP as a core-conserved binding motif. The function of the SH3 domain is not well understood but they may mediate many diverse processes such as increasing local concentration of proteins, altering their subcellular location and mediating the assembly of large multiprotein complexes [PubMed7953536].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 58 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a SH3-domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 58 hidden Markov models representing the SH3-domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]