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SH3-domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   SH3-like barrel [ 50036] (21)
Superfamily:   SH3-domain [ 50044]
Families:   SH3-domain [ 50045] (39)


Superfamily statistics
Genomes (730) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 39,125 44,557 127
Proteins 30,413 34,695 122


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) response to stimulus 0.0000000003807 Least Informative Direct
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0 Moderately Informative Direct
Biological Process (BP) cell communication 0 Moderately Informative Direct
Biological Process (BP) single organism signaling 0 Moderately Informative Direct
Biological Process (BP) cellular developmental process 0 Moderately Informative Direct
Biological Process (BP) regulation of localization 0 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.0000000000001747 Moderately Informative Direct
Biological Process (BP) regulation of signaling 0.000000000008031 Moderately Informative Direct
Biological Process (BP) cellular component assembly 0.0000000004686 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 0.0000000005274 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 0.000000003448 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.00000003673 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.0000001582 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.0000002533 Moderately Informative Direct
Biological Process (BP) cellular localization 0.0000004327 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.00001414 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.00005068 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.0001311 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.0004324 Moderately Informative Direct
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) protein complex biogenesis 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) system development 0.05887 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.7163 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.9601 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) nitrogen compound transport 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.07754 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.01231 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.01827 Moderately Informative Inherited
Biological Process (BP) reproduction 0.05495 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organophosphate biosynthetic process 0.4581 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) actin filament-based process 0 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0 Informative Direct
Biological Process (BP) vesicle-mediated transport 0 Informative Direct
Biological Process (BP) supramolecular fiber organization 0 Informative Direct
Biological Process (BP) positive regulation of transport 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) cytoskeleton organization 0 Informative Direct
Biological Process (BP) membrane organization 0.00000000000001439 Informative Direct
Biological Process (BP) cell development 0.0000000000005522 Informative Direct
Biological Process (BP) cell-cell signaling 0.0000000000006358 Informative Direct
Biological Process (BP) phosphorylation 0.00000000006243 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.000000002568 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0.000000003286 Informative Direct
Biological Process (BP) regulation of nervous system development 0.00000001647 Informative Direct
Biological Process (BP) response to nitrogen compound 0.00000004839 Informative Direct
Biological Process (BP) regulation of growth 0.00000005697 Informative Direct
Biological Process (BP) regulation of protein modification process 0.0000002164 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.0000002714 Informative Direct
Biological Process (BP) cell surface receptor signaling pathway 0.0000009295 Informative Direct
Biological Process (BP) cellular chemical homeostasis 0.000002275 Informative Direct
Biological Process (BP) behavior 0.000002676 Informative Direct
Biological Process (BP) regulation of locomotion 0.000003749 Informative Direct
Biological Process (BP) regulation of intracellular signal transduction 0.000003995 Informative Direct
Biological Process (BP) system process 0.000007385 Informative Direct
Biological Process (BP) cellular response to hormone stimulus 0.00002252 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0.0000248 Informative Direct
Biological Process (BP) positive regulation of cellular protein metabolic process 0.00005313 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0.00008937 Informative Direct
Biological Process (BP) metal ion transport 0.0001114 Informative Direct
Biological Process (BP) tissue development 0.0001229 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.0001387 Informative Direct
Biological Process (BP) multi-organism reproductive process 0.0001398 Informative Direct
Biological Process (BP) regulation of hydrolase activity 0.0001526 Informative Direct
Biological Process (BP) growth 0.0001971 Informative Direct
Biological Process (BP) single-organism intracellular transport 0.0002728 Informative Direct
Biological Process (BP) intracellular signal transduction 0.000399 Informative Direct
Biological Process (BP) glycerolipid metabolic process 0.0004363 Informative Direct
Biological Process (BP) positive regulation of cell death 0.0005096 Informative Direct
Biological Process (BP) pigment metabolic process 0.0007688 Informative Direct
Biological Process (BP) regulation of establishment of protein localization 1 Informative Inherited
Biological Process (BP) regulation of cell proliferation 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.07318 Informative Inherited
Biological Process (BP) regulation of cell differentiation 0.1137 Informative Inherited
Biological Process (BP) regulation of ion transport 1 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.00186 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 1 Informative Inherited
Biological Process (BP) protein localization to organelle 1 Informative Inherited
Biological Process (BP) response to organic cyclic compound 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.007945 Informative Inherited
Biological Process (BP) cellular protein complex assembly 0.193 Informative Inherited
Biological Process (BP) transmembrane transport 0.6945 Informative Inherited
Biological Process (BP) cell cycle process 0.9918 Informative Inherited
Biological Process (BP) ion homeostasis 0.5809 Informative Inherited
Biological Process (BP) circulatory system development 0.1652 Informative Inherited
Biological Process (BP) organelle assembly 0.003658 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.005043 Informative Inherited
Biological Process (BP) positive regulation of immune response 0.007262 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 1 Informative Inherited
Biological Process (BP) post-embryonic development 0.526 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) negative regulation of transport 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.2422 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) generation of neurons 0.002445 Informative Inherited
Biological Process (BP) regulation of phosphorylation 0.2072 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.5327 Informative Inherited
Biological Process (BP) regulation of transferase activity 1 Informative Inherited
Biological Process (BP) regulation of secretion 1 Informative Inherited
Biological Process (BP) regulation of peptide transport 1 Informative Inherited
Biological Process (BP) regulation of cellular localization 1 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.05308 Informative Inherited
Biological Process (BP) organelle localization 1 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) reproductive system development 1 Informative Inherited
Biological Process (BP) immune effector process 0.00129 Informative Inherited
Biological Process (BP) immune response 0.109 Informative Inherited
Biological Process (BP) secondary metabolic process 0.06015 Informative Inherited
Biological Process (BP) regulation of transmembrane transport 0.5594 Informative Inherited
Biological Process (BP) positive regulation of gene expression 0.9948 Informative Inherited
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.03246 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.984 Informative Inherited
Biological Process (BP) cell activation 0.001384 Informative Inherited
Biological Process (BP) sensory organ development 0.1002 Informative Inherited
Biological Process (BP) negative regulation of molecular function 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.7716 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.02358 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.1029 Informative Inherited
Biological Process (BP) regulation of proteolysis 1 Informative Inherited
Biological Process (BP) phospholipid metabolic process 0.05327 Informative Inherited
Biological Process (BP) intracellular protein transport 1 Informative Inherited
Biological Process (BP) regulation of defense response 1 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.7206 Informative Inherited
Biological Process (BP) embryo development 0.009485 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.0149 Informative Inherited
Biological Process (BP) trans-synaptic signaling 0 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.000000000000001945 Highly Informative Direct
Biological Process (BP) divalent metal ion transport 0.000000000000003764 Highly Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 0.000000000000028 Highly Informative Direct
Biological Process (BP) response to peptide hormone 0.0000000000000446 Highly Informative Direct
Biological Process (BP) regulation of cell shape 0.000000000003325 Highly Informative Direct
Biological Process (BP) regulation of GTPase activity 0.00000000002194 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 0.00000000002498 Highly Informative Direct
Biological Process (BP) cellular response to organonitrogen compound 0.00000000003347 Highly Informative Direct
Biological Process (BP) regulation of protein polymerization 0.00000000009285 Highly Informative Direct
Biological Process (BP) tube morphogenesis 0.0000000008989 Highly Informative Direct
Biological Process (BP) biological adhesion 0.000000001271 Highly Informative Direct
Biological Process (BP) endomembrane system organization 0.000000001777 Highly Informative Direct
Biological Process (BP) inorganic cation transmembrane transport 0.000000002002 Highly Informative Direct
Biological Process (BP) morphogenesis of an epithelium 0.00000000586 Highly Informative Direct
Biological Process (BP) actin filament organization 0.00000001269 Highly Informative Direct
Biological Process (BP) female gamete generation 0.00000003586 Highly Informative Direct
Biological Process (BP) muscle structure development 0.00000003934 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 0.0000003299 Highly Informative Direct
Biological Process (BP) regulation of ion homeostasis 0.0000003776 Highly Informative Direct
Biological Process (BP) small GTPase mediated signal transduction 0.0000006676 Highly Informative Direct
Biological Process (BP) regulation of actin polymerization or depolymerization 0.0000007093 Highly Informative Direct
Biological Process (BP) positive regulation of cellular component biogenesis 0.000003031 Highly Informative Direct
Biological Process (BP) cell projection assembly 0.000005399 Highly Informative Direct
Biological Process (BP) phagocytosis 0.000006769 Highly Informative Direct
Biological Process (BP) positive regulation of cell development 0.00001604 Highly Informative Direct
Biological Process (BP) nucleotide-sugar metabolic process 0.00001607 Highly Informative Direct
Biological Process (BP) cell division 0.00001779 Highly Informative Direct
Biological Process (BP) negative regulation of supramolecular fiber organization 0.00002083 Highly Informative Direct
Biological Process (BP) chemotaxis 0.00002362 Highly Informative Direct
Biological Process (BP) cellular component assembly involved in morphogenesis 0.00003471 Highly Informative Direct
Biological Process (BP) vesicle localization 0.00006188 Highly Informative Direct
Biological Process (BP) phosphatidylinositol metabolic process 0.0000661 Highly Informative Direct
Biological Process (BP) positive regulation of nervous system development 0.00009593 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 0.0001022 Highly Informative Direct
Biological Process (BP) wound healing 0.0001222 Highly Informative Direct
Biological Process (BP) multi-organism behavior 0.0001292 Highly Informative Direct
Biological Process (BP) glycerophospholipid biosynthetic process 0.0001342 Highly Informative Direct
Biological Process (BP) negative regulation of homeostatic process 0.0001926 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 0.000231 Highly Informative Direct
Biological Process (BP) neuron development 0.0002455 Highly Informative Direct
Biological Process (BP) negative regulation of growth 0.0003142 Highly Informative Direct
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.0003956 Highly Informative Direct
Biological Process (BP) immune response-activating signal transduction 0.0004342 Highly Informative Direct
Biological Process (BP) inner ear development 0.0009803 Highly Informative Direct
Biological Process (BP) regulation of transmembrane transporter activity 0.2719 Highly Informative Inherited
Biological Process (BP) regulation of cation transmembrane transport 0.3417 Highly Informative Inherited
Biological Process (BP) positive regulation of apoptotic process 0.004259 Highly Informative Inherited
Biological Process (BP) regulation of apoptotic signaling pathway 0.5781 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.008047 Highly Informative Inherited
Biological Process (BP) regulation of protein complex disassembly 0.3633 Highly Informative Inherited
Biological Process (BP) positive regulation of cell adhesion 0.0166 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 0.2524 Highly Informative Inherited
Biological Process (BP) renal system process 0.8479 Highly Informative Inherited
Biological Process (BP) protein localization to membrane 0.05381 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte migration 0.8225 Highly Informative Inherited
Biological Process (BP) kidney development 0.004122 Highly Informative Inherited
Biological Process (BP) actomyosin structure organization 1 Highly Informative Inherited
Biological Process (BP) single-organism behavior 0.008885 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.7196 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.00579 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 1 Highly Informative Inherited
Biological Process (BP) plasma membrane bounded cell projection organization 0.6458 Highly Informative Inherited
Biological Process (BP) transition metal ion homeostasis 0.9139 Highly Informative Inherited
Biological Process (BP) negative regulation of nervous system development 0.001817 Highly Informative Inherited
Biological Process (BP) cellular calcium ion homeostasis 0.01271 Highly Informative Inherited
Biological Process (BP) negative regulation of cytoskeleton organization 0.01713 Highly Informative Inherited
Biological Process (BP) negative regulation of protein complex assembly 0.002148 Highly Informative Inherited
Biological Process (BP) neurological system process 0.3514 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 0.004678 Highly Informative Inherited
Biological Process (BP) response to alcohol 0.6472 Highly Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.05763 Highly Informative Inherited
Biological Process (BP) positive regulation of protein transport 1 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular protein localization 0.001235 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.8581 Highly Informative Inherited
Biological Process (BP) regulation of protein import into nucleus 0.5028 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.443 Highly Informative Inherited
Biological Process (BP) post-embryonic animal morphogenesis 0.01364 Highly Informative Inherited
Biological Process (BP) appendage development 0.1762 Highly Informative Inherited
Biological Process (BP) epithelial cell differentiation 0.01169 Highly Informative Inherited
Biological Process (BP) negative regulation of phosphate metabolic process 0.714 Highly Informative Inherited
Biological Process (BP) innate immune response 0.04613 Highly Informative Inherited
Biological Process (BP) developmental growth involved in morphogenesis 1 Highly Informative Inherited
Biological Process (BP) positive regulation of lymphocyte activation 0.8929 Highly Informative Inherited
Biological Process (BP) sex differentiation 0.8675 Highly Informative Inherited
Biological Process (BP) hemostasis 0.0012 Highly Informative Inherited
Biological Process (BP) coagulation 0.02465 Highly Informative Inherited
Biological Process (BP) macromolecule glycosylation 0.04565 Highly Informative Inherited
Biological Process (BP) protein import 0.5955 Highly Informative Inherited
Biological Process (BP) sensory organ morphogenesis 0.1309 Highly Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 1 Highly Informative Inherited
Biological Process (BP) pattern specification process 1 Highly Informative Inherited
Biological Process (BP) germ cell development 0.3996 Highly Informative Inherited
Biological Process (BP) MAPK cascade 0.06602 Highly Informative Inherited
Biological Process (BP) regulation of cysteine-type endopeptidase activity 0.03668 Highly Informative Inherited
Biological Process (BP) positive regulation of proteolysis 0.7264 Highly Informative Inherited
Biological Process (BP) glycoprotein metabolic process 0.2627 Highly Informative Inherited
Biological Process (BP) camera-type eye development 1 Highly Informative Inherited
Biological Process (BP) activation of innate immune response 1 Highly Informative Inherited
Biological Process (BP) cell proliferation 0.01172 Highly Informative Inherited
Biological Process (BP) gastrulation 1 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity 0.00549 Least Informative Inherited
Molecular Function (MF) molecular function regulator 0 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.0000000000002312 Moderately Informative Direct
Molecular Function (MF) structural molecule activity 0.0000000009391 Moderately Informative Direct
Molecular Function (MF) anion binding 0.000002086 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 1 Moderately Informative Inherited
Molecular Function (MF) transporter activity 0.8793 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 1 Moderately Informative Inherited
Molecular Function (MF) phospholipid binding 0 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0 Informative Direct
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) enzyme binding 0.000000000005304 Informative Direct
Molecular Function (MF) macromolecular complex binding 0.00000000003056 Informative Direct
Molecular Function (MF) passive transmembrane transporter activity 0.0000001445 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 0.0000001794 Informative Direct
Molecular Function (MF) enzyme activator activity 0.00001264 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 1 Informative Inherited
Molecular Function (MF) receptor binding 0.007215 Informative Inherited
Molecular Function (MF) ATPase activity 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 0.7917 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.8326 Informative Inherited
Molecular Function (MF) signal transducer activity 1 Informative Inherited
Molecular Function (MF) protein domain specific binding 0 Highly Informative Direct
Molecular Function (MF) phosphotransferase activity, phosphate group as acceptor 0 Highly Informative Direct
Molecular Function (MF) GTPase regulator activity 0 Highly Informative Direct
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0 Highly Informative Direct
Molecular Function (MF) nucleobase-containing compound kinase activity 0.000000000000001646 Highly Informative Direct
Molecular Function (MF) cell adhesion molecule binding 0.00000000003662 Highly Informative Direct
Molecular Function (MF) ion channel activity 0.000000005634 Highly Informative Direct
Molecular Function (MF) gated channel activity 0.000004929 Highly Informative Direct
Molecular Function (MF) phospholipase activity 0.00009561 Highly Informative Direct
Molecular Function (MF) phosphoric diester hydrolase activity 0.0003705 Highly Informative Direct
Molecular Function (MF) kinase binding 0.0004536 Highly Informative Direct
Molecular Function (MF) protein transporter activity 0.03952 Highly Informative Inherited
Molecular Function (MF) small GTPase binding 1 Highly Informative Inherited
Molecular Function (MF) transferase activity, transferring hexosyl groups 0.09002 Highly Informative Inherited
Molecular Function (MF) protein kinase activity 0.4166 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0 Least Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0.00000000004286 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) macromolecular complex 0.6163 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) vesicle 0 Moderately Informative Direct
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0 Moderately Informative Direct
Cellular Component (CC) endoplasmic reticulum 1 Moderately Informative Inherited
Cellular Component (CC) extracellular region part 0.4162 Moderately Informative Inherited
Cellular Component (CC) intrinsic component of membrane 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) transferase complex 1 Moderately Informative Inherited
Cellular Component (CC) whole membrane 0.749 Moderately Informative Inherited
Cellular Component (CC) bounding membrane of organelle 1 Moderately Informative Inherited
Cellular Component (CC) actin cytoskeleton 0 Informative Direct
Cellular Component (CC) apical part of cell 0 Informative Direct
Cellular Component (CC) synapse 0 Informative Direct
Cellular Component (CC) transporter complex 0 Informative Direct
Cellular Component (CC) plasma membrane region 0 Informative Direct
Cellular Component (CC) cytoplasmic region 0 Informative Direct
Cellular Component (CC) supramolecular polymer 0 Informative Direct
Cellular Component (CC) extrinsic component of membrane 0.0000001639 Informative Direct
Cellular Component (CC) membrane region 0.0000005803 Informative Direct
Cellular Component (CC) extracellular organelle 0.00001716 Informative Direct
Cellular Component (CC) endosome 0.00002486 Informative Direct
Cellular Component (CC) cilium 0.0002159 Informative Direct
Cellular Component (CC) transferase complex, transferring phosphorus-containing groups 0.8983 Informative Inherited
Cellular Component (CC) cell surface 1 Informative Inherited
Cellular Component (CC) extracellular space 0.953 Informative Inherited
Cellular Component (CC) neuron projection 0.4192 Informative Inherited
Cellular Component (CC) plasma membrane bounded cell projection part 0.008447 Informative Inherited
Cellular Component (CC) oxidoreductase complex 0.3348 Informative Inherited
Cellular Component (CC) cytoplasmic vesicle part 0.557 Informative Inherited
Cellular Component (CC) side of membrane 0.7245 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) microbody 0.4539 Informative Inherited
Cellular Component (CC) ruffle 0 Highly Informative Direct
Cellular Component (CC) cell division site part 0.000000000000185 Highly Informative Direct
Cellular Component (CC) contractile fiber part 0.0000000001195 Highly Informative Direct
Cellular Component (CC) cortical actin cytoskeleton 0.0000000002288 Highly Informative Direct
Cellular Component (CC) extrinsic component of cytoplasmic side of plasma membrane 0.000000005399 Highly Informative Direct
Cellular Component (CC) midbody 0.000006978 Highly Informative Direct
Cellular Component (CC) extracellular vesicle 1 Highly Informative Inherited
Cellular Component (CC) intrinsic component of plasma membrane 1 Highly Informative Inherited
Cellular Component (CC) sarcolemma 0.004186 Highly Informative Inherited
Cellular Component (CC) myofibril 0.003521 Highly Informative Inherited
Cellular Component (CC) receptor complex 0.01488 Highly Informative Inherited
Cellular Component (CC) cell-cell junction 0.6444 Highly Informative Inherited
Cellular Component (CC) peroxisomal part 0.001012 Highly Informative Inherited
Cellular Component (CC) microbody membrane 0.001142 Highly Informative Inherited
Cellular Component (CC) microtubule organizing center 1 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0.4052Least InformativeInherited
Enzyme Commission (EC)Phosphoric diester hydrolases0.00000006272Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.0001767Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Phosphoinositide phospholipase C0.000000000000003251InformativeDirect
Enzyme Commission (EC)Mitogen-activated protein kinase kinase kinase0.0000000000002472Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the face0.2847Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the immune system0.2899Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.4112Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.5713Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.8132Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.1689Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.2365Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal inflammatory response0.2884Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the oral cavity0.3536Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.4184Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of oral mucosa0.1174InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin physiology0.1242InformativeInherited
Phenotypic Abnormality (PA)Recurrent infections0.1522InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lymphatic system0.1637InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal physiology0.2066InformativeInherited
Phenotypic Abnormality (PA)Abnormality of bone marrow cell morphology0.5763InformativeInherited
Phenotypic Abnormality (PA)Abnormality of mitochondrial metabolism0.7532InformativeInherited
Phenotypic Abnormality (PA)Cellulitis0.000002438Highly InformativeDirect
Phenotypic Abnormality (PA)Recurrent aphthous stomatitis0.00002738Highly InformativeDirect
Phenotypic Abnormality (PA)Osteomyelitis0.0002303Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype0.008777Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.03669Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.05321Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.7549Least InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.07319Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.09062Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.144Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.1675Moderately InformativeInherited
Mammalian Phenotype (MP)hearing/vestibular/ear phenotype0.1927Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.2772Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.4785Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.5006Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.7967Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.8118Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.8191Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.963Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal B cell proliferation0.000267InformativeDirect
Mammalian Phenotype (MP)abnormal cerebral hemisphere morphology0.08705InformativeInherited
Mammalian Phenotype (MP)abnormal limbic system morphology0.1096InformativeInherited
Mammalian Phenotype (MP)abnormal neuron physiology0.2852InformativeInherited
Mammalian Phenotype (MP)abnormal enzyme/coenzyme activity0.2906InformativeInherited
Mammalian Phenotype (MP)abnormal CNS synaptic transmission0.3487InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear hair cell morphology0.3783InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin secretion0.392InformativeInherited
Mammalian Phenotype (MP)abnormal T cell differentiation0.4033InformativeInherited
Mammalian Phenotype (MP)abnormal effector T cell morphology0.4646InformativeInherited
Mammalian Phenotype (MP)abnormal alpha-beta T cell morphology0.5181InformativeInherited
Mammalian Phenotype (MP)abnormal synaptic vesicle recycling0.000008204Highly InformativeDirect
Mammalian Phenotype (MP)abnormal interleukin-2 secretion0.0004184Highly InformativeDirect
Mammalian Phenotype (MP)decreased excitatory postsynaptic current amplitude0.000489Highly InformativeDirect
Mammalian Phenotype (MP)abnormal hippocampus pyramidal cell layer0.0009106Highly InformativeDirect
Mammalian Phenotype (MP)abnormal granulocyte physiology0.05748Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear hair cell stereociliary bundle morphology0.08328Highly InformativeInherited
Mammalian Phenotype (MP)abnormal CD8-positive, alpha beta T cell morphology0.284Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

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WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell morphology variant0.0000003537Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.000005457Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.00007853Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.01711Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.02014Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.03029Least InformativeInherited
Worm Phenotype (WP)protein expression variant0.00000000626Moderately InformativeDirect
Worm Phenotype (WP)apoptosis variant0.0001295Moderately InformativeDirect
Worm Phenotype (WP)chemical response variant0.05462Moderately InformativeInherited
Worm Phenotype (WP)cell component morphology variant0.1556Moderately InformativeInherited
Worm Phenotype (WP)germ cell morphology variant0.4323Moderately InformativeInherited
Worm Phenotype (WP)muscle cell physiology variant0.000000000001353InformativeDirect
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.000000000005761InformativeDirect
Worm Phenotype (WP)mitochondria morphology variant0.000001276InformativeDirect
Worm Phenotype (WP)aldicarb response variant0.0003905InformativeDirect
Worm Phenotype (WP)level of protein expression variant0.01648InformativeInherited
Worm Phenotype (WP)protein modification variant0.6087InformativeInherited
Worm Phenotype (WP)oocyte morphology variant0.9242InformativeInherited
Worm Phenotype (WP)protein expression reduced0.000000000009178Highly InformativeDirect
Worm Phenotype (WP)body elongation variant0.0002233Highly InformativeDirect
Worm Phenotype (WP)mitochondria alignment variant0.0002663Highly InformativeDirect
Worm Phenotype (WP)endomitotic oocytes0.0004088Highly InformativeDirect
Worm Phenotype (WP)ovulation variant0.0005488Highly InformativeDirect
Worm Phenotype (WP)protein phosphorylation variant0.0006521Highly InformativeDirect
Worm Phenotype (WP)cytoskeleton organization biogenesis variant0.03619Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

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YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)morphology0.1479Moderately InformativeInherited
Yeast Phenotype (YP)intracellular transport0.00002072InformativeDirect
Yeast Phenotype (YP)subcellular morphology0.314InformativeInherited
Yeast Phenotype (YP)chitin deposition0.0003521Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

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FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)cell component0.0007065InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

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AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)portion of meristem tissue0Least InformativeDirect
Plant ANatomical entity (PAN)megasporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)sporangium0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence meristem0Moderately InformativeDirect
Plant ANatomical entity (PAN)cotyledon0Moderately InformativeDirect
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.12 twelve leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.08 eight leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.02 two leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

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EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0.0001024Moderately InformativeDirect
Enzyme Commission (EC)Transferring one-carbon groups1Moderately InformativeInherited
Enzyme Commission (EC)Acyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)RING-type E3 ubiquitin transferase0.000000001446InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0.00000001269InformativeDirect
Enzyme Commission (EC)Hexosyltransferases0.0000743InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0Highly InformativeDirect
Enzyme Commission (EC)Phosphoinositide phospholipase C0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

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KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.3825Least InformativeInherited
Biological processImmunity0Moderately InformativeDirect
Biological processProtein transport0Moderately InformativeDirect
Biological processDifferentiation0.000000001106Moderately InformativeDirect
Biological processApoptosis0.000000001159Moderately InformativeDirect
Biological processCell cycle0.000576Moderately InformativeDirect
Biological processIon transport0.692Moderately InformativeInherited
Biological processEndocytosis0InformativeDirect
Biological processStress response0InformativeDirect
Biological processCell adhesion0.00000000001768InformativeDirect
Biological processNeurogenesis0.0000000002943InformativeDirect
Biological processMitosis0.000000002074InformativeDirect
Biological processInflammatory response0.00001202InformativeDirect
Biological processAutophagy0.0003191InformativeDirect
Biological processCalcium transport0Highly InformativeDirect
Biological processPhagocytosis0.0000000000002786Highly InformativeDirect
Biological processAdaptive immunity0.000000000007959Highly InformativeDirect
Biological processCilium biogenesis/degradation0.0000000005843Highly InformativeDirect
Biological processExocytosis0.0000007128Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentGolgi apparatus0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentEndosome0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0Moderately InformativeDirect
Cellular componentCell membrane0.000000016Moderately InformativeDirect
Cellular componentLysosome0.00001103InformativeDirect
Cellular componentCoated pit0Highly InformativeDirect
Coding sequence diversityAlternative splicing0.000000001913Least InformativeDirect
Coding sequence diversityChromosomal rearrangement0.00009767InformativeDirect
DiseaseProto-oncogene0Moderately InformativeDirect
DomainRepeat0.000124Least InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
DomainSH2 domain0InformativeDirect
DomainSH3 domain0InformativeDirect
DomainSH3-binding0InformativeDirect
DomainANK repeat0.00000001965InformativeDirect
Molecular functionLipid-binding0Moderately InformativeDirect
Molecular functionCalcium0.000001681Moderately InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0.000000143Moderately InformativeDirect
Post-translational modificationActin-binding0InformativeDirect
Post-translational modificationCalmodulin-binding0InformativeDirect
Post-translational modificationGTPase activation0InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor0InformativeDirect
Post-translational modificationIon channel0.000002197InformativeDirect
Post-translational modificationCalcium channel0Highly InformativeDirect
Post-translational modificationMyosin0Highly InformativeDirect
Post-translational modificationTyrosine-protein kinase0Highly InformativeDirect
Post-translational modificationVoltage-gated channel0.0000000000001343Highly InformativeDirect
Post-translational modificationActin capping0.00000001331Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationMyristate0InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein glycosylation0.00001685InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR001452 SSF50044 Protein matches
Abstract SH3 (src Homology-3) domains are small protein modules containing approximately 50 amino acid residues [PubMed15335710, PubMed11256992]. They are found in a great variety of intracellular or membrane-associated proteins [PubMed1639195, PubMed14731533, PubMed7531822] for example, in a variety of proteins with enzymatic activity, in adaptor proteins that lack catalytic sequences and in cytoskeletal proteins, such as fodrin and yeast actin binding protein ABP-1.

The SH3 domain has a characteristic fold which consists of five or six beta-strands arranged as two tightly packed anti-parallel beta sheets. The linker regions may contain short helices. The surface of the SH2-domain bears a flat, hydrophobic ligand-binding pocket which consists of three shallow grooves defined by conservative aromatic residues in which the ligand adopts an extended left-handed helical arrangement. The ligand binds with low affinity but this may be enhanced by multiple interactions. The region bound by the SH3 domain is in all cases proline-rich and contains PXXP as a core-conserved binding motif. The function of the SH3 domain is not well understood but they may mediate many diverse processes such as increasing local concentration of proteins, altering their subcellular location and mediating the assembly of large multiprotein complexes [PubMed7953536].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 58 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a SH3-domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 58 hidden Markov models representing the SH3-domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]