SUPERFAMILY 1.75 HMM library and genome assignments server


Myosin S1 fragment, N-terminal domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   SH3-like barrel [ 50036] (21)
Superfamily:   Myosin S1 fragment, N-terminal domain [ 50084]
Families:   Myosin S1 fragment, N-terminal domain [ 50085]


Superfamily statistics
Genomes (283) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 505 454 0
Proteins 505 454 0


Functional annotation
General category Processes_IC
Detailed category Cell motility

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular component organization or biogenesis7.307e-060Least InformativeDirect
Biological Process (BP)developmental process0.000142.78e-14Least InformativeDirect
Biological Process (BP)multicellular organismal process0.00034173.663e-09Least InformativeDirect
Biological Process (BP)single-organism cellular process0.0012696.041e-07Least InformativeInherited
Biological Process (BP)tissue development9.611e-083.525e-05Moderately InformativeDirect
Biological Process (BP)anatomical structure morphogenesis8.399e-071.239e-06Moderately InformativeDirect
Biological Process (BP)single-organism developmental process0.00094352.994e-07Moderately InformativeDirect
Biological Process (BP)cellular component biogenesis0.08380.007833Moderately InformativeInherited
Biological Process (BP)organelle organization0.0044149.538e-12Moderately InformativeInherited
Biological Process (BP)cell differentiation2.053e-061Moderately InformativeInherited
Biological Process (BP)organ development3.163e-060.04947Moderately InformativeInherited
Biological Process (BP)system process0.0019446.953e-05Moderately InformativeInherited
Biological Process (BP)organelle assembly5.799e-096.57e-09InformativeDirect
Biological Process (BP)actin filament-based process6.514e-080InformativeDirect
Biological Process (BP)cytoskeleton organization8.601e-074.115e-05InformativeDirect
Biological Process (BP)muscle structure development4.96e-067.675e-09InformativeDirect
Biological Process (BP)cellular component movement3.647e-050InformativeDirect
Biological Process (BP)anatomical structure formation involved in morphogenesis0.00016572.065e-09InformativeDirect
Biological Process (BP)muscle tissue development0.00018911.234e-06InformativeDirect
Biological Process (BP)cellular component morphogenesis0.00022562.469e-08InformativeDirect
Biological Process (BP)cardiovascular system development0.0048323.361e-05InformativeInherited
Biological Process (BP)embryo development ending in birth or egg hatching2.642e-060.1393InformativeInherited
Biological Process (BP)actomyosin structure organization1.128e-112.85e-09Highly InformativeDirect
Biological Process (BP)cellular component assembly involved in morphogenesis9.904e-079.884e-13Highly InformativeDirect
Biological Process (BP)actin filament-based movement1.548e-064.658e-11Highly InformativeDirect
Biological Process (BP)cardiocyte differentiation7.684e-063.382e-13Highly InformativeDirect
Biological Process (BP)muscle fiber development1.579e-110.9903Highly InformativeInherited
Biological Process (BP)cardiac muscle tissue development0.0079721.085e-08Highly InformativeInherited
Molecular Function (MF)hydrolase activity0.001323.476e-09Least InformativeInherited
Molecular Function (MF)nucleoside-triphosphatase activity1.737e-060InformativeDirect
Cellular Component (CC)intracellular non-membrane-bounded organelle00Least InformativeDirect
Cellular Component (CC)protein complex6.307e-080Least InformativeDirect
Cellular Component (CC)intracellular organelle part0.00090568.859e-13Least InformativeDirect
Cellular Component (CC)cytoplasmic part00.02075Least InformativeInherited
Cellular Component (CC)cytoskeleton0.011691.854e-10Moderately InformativeInherited
Cellular Component (CC)actin cytoskeleton00InformativeDirect
Cellular Component (CC)contractile fiber part4.11e-123.404e-08InformativeDirect
Cellular Component (CC)myosin complex1.76e-130Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) developmental process 2.78e-14 Least Informative Direct
Biological Process (BP) multicellular organismal process 3.663e-09 Least Informative Direct
Biological Process (BP) single-organism cellular process 6.041e-07 Least Informative Direct
Biological Process (BP) response to stimulus 0.0005209 Least Informative Direct
Biological Process (BP) localization 3.745e-09 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.1923 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.007673 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.004922 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.002716 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.03204 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.02187 Least Informative Inherited
Biological Process (BP) tissue development 3.525e-05 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 1.239e-06 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 2.994e-07 Moderately Informative Direct
Biological Process (BP) system process 6.953e-05 Moderately Informative Direct
Biological Process (BP) organelle organization 9.538e-12 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 1.929e-08 Moderately Informative Direct
Biological Process (BP) cellular localization 5.235e-08 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 1.632e-07 Moderately Informative Direct
Biological Process (BP) organonitrogen compound catabolic process 7.144e-07 Moderately Informative Direct
Biological Process (BP) organic cyclic compound catabolic process 6.642e-06 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 1.332e-05 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 1.779e-05 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 2.383e-05 Moderately Informative Direct
Biological Process (BP) reproduction 2.637e-05 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0.0002731 Moderately Informative Direct
Biological Process (BP) cellular component biogenesis 0.007833 Moderately Informative Inherited
Biological Process (BP) organ development 0.04947 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.03183 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.04896 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.9901 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.001879 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.1884 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.7538 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.01392 Moderately Informative Inherited
Biological Process (BP) organelle assembly 6.57e-09 Informative Direct
Biological Process (BP) actin filament-based process 0 Informative Direct
Biological Process (BP) cytoskeleton organization 4.115e-05 Informative Direct
Biological Process (BP) muscle structure development 7.675e-09 Informative Direct
Biological Process (BP) cellular component movement 0 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 2.065e-09 Informative Direct
Biological Process (BP) muscle tissue development 1.234e-06 Informative Direct
Biological Process (BP) cellular component morphogenesis 2.469e-08 Informative Direct
Biological Process (BP) cardiovascular system development 3.361e-05 Informative Direct
Biological Process (BP) generation of neurons 1.795e-12 Informative Direct
Biological Process (BP) locomotion 9.241e-11 Informative Direct
Biological Process (BP) nucleoside monophosphate metabolic process 8.622e-10 Informative Direct
Biological Process (BP) organelle localization 5.4e-09 Informative Direct
Biological Process (BP) glycosyl compound catabolic process 6.338e-09 Informative Direct
Biological Process (BP) nucleoside triphosphate metabolic process 7.742e-09 Informative Direct
Biological Process (BP) organophosphate catabolic process 1.376e-08 Informative Direct
Biological Process (BP) purine ribonucleoside metabolic process 1.878e-08 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 3.238e-08 Informative Direct
Biological Process (BP) purine ribonucleotide metabolic process 3.273e-08 Informative Direct
Biological Process (BP) secretion by cell 8.314e-08 Informative Direct
Biological Process (BP) response to wounding 9.592e-07 Informative Direct
Biological Process (BP) cell cycle process 3.937e-06 Informative Direct
Biological Process (BP) nucleobase-containing compound catabolic process 4.867e-06 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 1.164e-05 Informative Direct
Biological Process (BP) sensory organ development 1.542e-05 Informative Direct
Biological Process (BP) cell projection organization 1.82e-05 Informative Direct
Biological Process (BP) cellular macromolecular complex assembly 2.445e-05 Informative Direct
Biological Process (BP) protein complex assembly 0.000127 Informative Direct
Biological Process (BP) membrane organization 0.0001323 Informative Direct
Biological Process (BP) localization of cell 0.0009164 Informative Direct
Biological Process (BP) regulation of cell development 0.03794 Informative Inherited
Biological Process (BP) microtubule-based process 0.001125 Informative Inherited
Biological Process (BP) central nervous system development 0.05125 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.1573 Informative Inherited
Biological Process (BP) single organism reproductive process 0.0408 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.07638 Informative Inherited
Biological Process (BP) sexual reproduction 0.3451 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.002533 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.001493 Informative Inherited
Biological Process (BP) protein transport 0.02464 Informative Inherited
Biological Process (BP) organ morphogenesis 0.2567 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.1393 Informative Inherited
Biological Process (BP) actomyosin structure organization 2.85e-09 Highly Informative Direct
Biological Process (BP) cellular component assembly involved in morphogenesis 9.884e-13 Highly Informative Direct
Biological Process (BP) actin filament-based movement 4.658e-11 Highly Informative Direct
Biological Process (BP) cardiocyte differentiation 3.382e-13 Highly Informative Direct
Biological Process (BP) cardiac muscle tissue development 1.085e-08 Highly Informative Direct
Biological Process (BP) wound healing 3.013e-12 Highly Informative Direct
Biological Process (BP) cell division 1.131e-11 Highly Informative Direct
Biological Process (BP) chemotaxis 9.524e-11 Highly Informative Direct
Biological Process (BP) nucleoside monophosphate catabolic process 1.664e-10 Highly Informative Direct
Biological Process (BP) ATP metabolic process 2.441e-10 Highly Informative Direct
Biological Process (BP) purine ribonucleoside triphosphate catabolic process 2.713e-09 Highly Informative Direct
Biological Process (BP) purine ribonucleoside catabolic process 4.039e-09 Highly Informative Direct
Biological Process (BP) purine ribonucleotide catabolic process 4.591e-09 Highly Informative Direct
Biological Process (BP) neuromuscular process 4.115e-08 Highly Informative Direct
Biological Process (BP) exocytosis 3.819e-07 Highly Informative Direct
Biological Process (BP) retina development in camera-type eye 1.117e-06 Highly Informative Direct
Biological Process (BP) cell projection assembly 1.306e-06 Highly Informative Direct
Biological Process (BP) telencephalon development 1.433e-06 Highly Informative Direct
Biological Process (BP) plasma membrane organization 1.524e-06 Highly Informative Direct
Biological Process (BP) female gamete generation 3.421e-06 Highly Informative Direct
Biological Process (BP) spermatogenesis 5.755e-06 Highly Informative Direct
Biological Process (BP) regulation of reproductive process 5.77e-05 Highly Informative Direct
Biological Process (BP) cell proliferation 6.895e-05 Highly Informative Direct
Biological Process (BP) microtubule-based movement 0.03381 Highly Informative Inherited
Biological Process (BP) neuron projection development 0.8753 Highly Informative Inherited
Biological Process (BP) cell part morphogenesis 0.951 Highly Informative Inherited
Biological Process (BP) muscle fiber development 0.9903 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.5032 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.07169 Highly Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.01081 Highly Informative Inherited
Biological Process (BP) epithelial cell development 0.05675 Highly Informative Inherited
Biological Process (BP) photoreceptor cell differentiation 0.007559 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 0.07192 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 3.476e-09 Least Informative Direct
Molecular Function (MF) binding 2.607e-07 Least Informative Direct
Molecular Function (MF) anion binding 0.01732 Moderately Informative Inherited
Molecular Function (MF) nucleoside-triphosphatase activity 0 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 8.517e-10 Informative Direct
Molecular Function (MF) purine ribonucleoside binding 1.379e-09 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 1.407e-08 Informative Direct
Molecular Function (MF) nucleotide binding 3.003e-08 Informative Direct
Molecular Function (MF) ATP binding 2.884e-11 Highly Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) protein complex 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 8.859e-13 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.02075 Least Informative Inherited
Cellular Component (CC) cytoskeleton 1.854e-10 Moderately Informative Direct
Cellular Component (CC) cell projection 1.176e-10 Moderately Informative Direct
Cellular Component (CC) actin cytoskeleton 0 Informative Direct
Cellular Component (CC) contractile fiber part 3.404e-08 Informative Direct
Cellular Component (CC) cell cortex 2.972e-15 Informative Direct
Cellular Component (CC) neuron projection 0.6864 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) myosin complex 0 Highly Informative Direct
Cellular Component (CC) cell body 3.305e-14 Highly Informative Direct
Cellular Component (CC) neuromuscular junction 3.032e-13 Highly Informative Direct
Cellular Component (CC) neuron spine 2.737e-08 Highly Informative Direct
Cellular Component (CC) growth cone 1.505e-05 Highly Informative Direct
Cellular Component (CC) spindle 0.0005905 Highly Informative Direct
Cellular Component (CC) dendrite 0.002289 Highly Informative Inherited

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.0002799Least InformativeDirect
Biological processCell cycle1.245e-06Moderately InformativeDirect
Biological processProtein transport2.547e-05Moderately InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionCalmodulin-binding0InformativeDirect
Molecular functionActin-binding0InformativeDirect
Post-translational modificationMyosin0Highly InformativeDirect
Post-translational modificationPhosphoprotein9.35e-05Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR008989 SSF50084 Protein matches
Abstract

Myosin is a molecular motor that undergoes ATP-driven conformational changes during force production and motility. The S1 fragment myosin head consists of both the globular motor domain, containing the ATP- and actin-binding sites, and the lever arm, which amplifies small conformational changes in the motor domain into larger motions by which myosin moves actin. The motor domain contains four major subdomains linked by three single-stranded joints: the N-terminal subdomain, the upper 50-kDa subdomain, the lower 50-kDa subdomain, and the C-terminal converter subdomain [PubMed11016966]. The N-terminal subdomain has an SH3-like partly opened beta barrel topology, with the last strand being interrupted by a 3-10 helical turn. The N-terminal and upper 50-kDa subdomains together form the nucleotide-binding pocket. The binding of specific nucleotides alters the structural state of the myosin head during the contractile cycle.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 6 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Myosin S1 fragment, N-terminal domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 6 hidden Markov models representing the Myosin S1 fragment, N-terminal domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]