SUPERFAMILY 1.75 HMM library and genome assignments server


Myosin S1 fragment, N-terminal domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   SH3-like barrel [ 50036] (21)
Superfamily:   Myosin S1 fragment, N-terminal domain [ 50084]
Families:   Myosin S1 fragment, N-terminal domain [ 50085]


Superfamily statistics
Genomes (303) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 535 589 0
Proteins 535 588 0


Functional annotation
General category Processes_IC
Detailed category Cell motility

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular component organization or biogenesis8.115e-060Least InformativeDirect
Biological Process (BP)developmental process0.00014181.271e-13Least InformativeDirect
Biological Process (BP)multicellular organismal process0.00034431.438e-08Least InformativeDirect
Biological Process (BP)single-organism cellular process0.0013071.068e-06Least InformativeInherited
Biological Process (BP)tissue development1.055e-071.646e-05Moderately InformativeDirect
Biological Process (BP)anatomical structure morphogenesis8.915e-072.605e-06Moderately InformativeDirect
Biological Process (BP)cellular component biogenesis0.081420.01335Moderately InformativeInherited
Biological Process (BP)organelle organization0.0044553.328e-11Moderately InformativeInherited
Biological Process (BP)cell differentiation2.438e-061Moderately InformativeInherited
Biological Process (BP)organ development3.566e-060.03028Moderately InformativeInherited
Biological Process (BP)system process0.0021180.0002089Moderately InformativeInherited
Biological Process (BP)actin filament-based process4.243e-120InformativeDirect
Biological Process (BP)organelle assembly7.836e-096.797e-08InformativeDirect
Biological Process (BP)cellular component movement6.463e-070InformativeDirect
Biological Process (BP)cytoskeleton organization8.049e-079.196e-05InformativeDirect
Biological Process (BP)muscle structure development5.996e-065.596e-08InformativeDirect
Biological Process (BP)anatomical structure formation involved in morphogenesis0.00017619.065e-09InformativeDirect
Biological Process (BP)cellular component morphogenesis0.00023199.424e-08InformativeDirect
Biological Process (BP)muscle tissue development0.00024351.386e-06InformativeDirect
Biological Process (BP)cardiovascular system development0.0047942.723e-05InformativeInherited
Biological Process (BP)muscle system process0.00066290.006602InformativeInherited
Biological Process (BP)embryo development ending in birth or egg hatching2.551e-060.1695InformativeInherited
Biological Process (BP)actomyosin structure organization1.059e-112.1e-08Highly InformativeDirect
Biological Process (BP)actin filament-based movement1.006e-071.988e-12Highly InformativeDirect
Biological Process (BP)cellular component assembly involved in morphogenesis1.192e-061.516e-11Highly InformativeDirect
Biological Process (BP)cardiocyte differentiation6.705e-069.575e-14Highly InformativeDirect
Biological Process (BP)muscle fiber development1.589e-110.8907Highly InformativeInherited
Biological Process (BP)cardiac muscle tissue development0.005567.866e-09Highly InformativeInherited
Molecular Function (MF)hydrolase activity0.0012821.435e-07Least InformativeInherited
Molecular Function (MF)nucleoside-triphosphatase activity1.542e-066.053e-15InformativeDirect
Cellular Component (CC)intracellular non-membrane-bounded organelle00Least InformativeDirect
Cellular Component (CC)protein complex6.428e-080Least InformativeDirect
Cellular Component (CC)cytoplasmic part00.02143Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.0011195.068e-12Least InformativeInherited
Cellular Component (CC)cytoskeleton0.0062232.632e-11Moderately InformativeInherited
Cellular Component (CC)actin cytoskeleton00InformativeDirect
Cellular Component (CC)contractile fiber part3.155e-123.516e-07InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) developmental process 1.271e-13 Least Informative Direct
Biological Process (BP) multicellular organismal process 1.438e-08 Least Informative Direct
Biological Process (BP) single-organism cellular process 1.068e-06 Least Informative Direct
Biological Process (BP) localization 2.13e-09 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.2086 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.01863 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.01183 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.006981 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.05783 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.04492 Least Informative Inherited
Biological Process (BP) response to stimulus 0.001268 Least Informative Inherited
Biological Process (BP) tissue development 1.646e-05 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 2.605e-06 Moderately Informative Direct
Biological Process (BP) system process 0.0002089 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.0009483 Moderately Informative Direct
Biological Process (BP) organelle organization 3.328e-11 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 6.342e-09 Moderately Informative Direct
Biological Process (BP) cellular localization 2.982e-08 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 7.027e-08 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 6.236e-05 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0.0001086 Moderately Informative Direct
Biological Process (BP) reproduction 0.0001226 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0.0001416 Moderately Informative Direct
Biological Process (BP) cellular component biogenesis 0.01335 Moderately Informative Inherited
Biological Process (BP) organ development 0.03028 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.02394 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.0439 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.005963 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.002488 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.001135 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.1899 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.7416 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.01467 Moderately Informative Inherited
Biological Process (BP) actin filament-based process 0 Informative Direct
Biological Process (BP) organelle assembly 6.797e-08 Informative Direct
Biological Process (BP) cellular component movement 0 Informative Direct
Biological Process (BP) cytoskeleton organization 9.196e-05 Informative Direct
Biological Process (BP) muscle structure development 5.596e-08 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 9.065e-09 Informative Direct
Biological Process (BP) cellular component morphogenesis 9.424e-08 Informative Direct
Biological Process (BP) muscle tissue development 1.386e-06 Informative Direct
Biological Process (BP) cardiovascular system development 2.723e-05 Informative Direct
Biological Process (BP) generation of neurons 1.358e-12 Informative Direct
Biological Process (BP) locomotion 1.053e-09 Informative Direct
Biological Process (BP) organelle localization 5.172e-09 Informative Direct
Biological Process (BP) nucleoside monophosphate metabolic process 1.568e-08 Informative Direct
Biological Process (BP) cellular membrane organization 2.924e-08 Informative Direct
Biological Process (BP) secretion by cell 5.722e-08 Informative Direct
Biological Process (BP) nucleoside triphosphate metabolic process 1.278e-07 Informative Direct
Biological Process (BP) organophosphate catabolic process 2.049e-07 Informative Direct
Biological Process (BP) purine ribonucleoside metabolic process 2.882e-07 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 4.231e-07 Informative Direct
Biological Process (BP) purine ribonucleotide metabolic process 4.527e-07 Informative Direct
Biological Process (BP) response to wounding 8.326e-07 Informative Direct
Biological Process (BP) cell cycle process 1.708e-06 Informative Direct
Biological Process (BP) organonitrogen compound catabolic process 6.183e-06 Informative Direct
Biological Process (BP) sensory organ development 9.296e-06 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 1.058e-05 Informative Direct
Biological Process (BP) cell projection organization 1.4e-05 Informative Direct
Biological Process (BP) nucleobase-containing compound catabolic process 1.887e-05 Informative Direct
Biological Process (BP) localization of cell 0.0009886 Informative Direct
Biological Process (BP) mitotic cell cycle 0.0009978 Informative Direct
Biological Process (BP) regulation of cell development 0.03943 Informative Inherited
Biological Process (BP) microtubule-based process 0.001021 Informative Inherited
Biological Process (BP) central nervous system development 0.05521 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.1447 Informative Inherited
Biological Process (BP) single organism reproductive process 0.03784 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.128 Informative Inherited
Biological Process (BP) sexual reproduction 0.2343 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.002406 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.14 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) muscle system process 0.006602 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.00142 Informative Inherited
Biological Process (BP) protein transport 0.02473 Informative Inherited
Biological Process (BP) organ morphogenesis 0.2321 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.1695 Informative Inherited
Biological Process (BP) actomyosin structure organization 2.1e-08 Highly Informative Direct
Biological Process (BP) actin filament-based movement 1.988e-12 Highly Informative Direct
Biological Process (BP) cellular component assembly involved in morphogenesis 1.516e-11 Highly Informative Direct
Biological Process (BP) cardiocyte differentiation 9.575e-14 Highly Informative Direct
Biological Process (BP) cardiac muscle tissue development 7.866e-09 Highly Informative Direct
Biological Process (BP) wound healing 2.613e-12 Highly Informative Direct
Biological Process (BP) cell division 4.739e-12 Highly Informative Direct
Biological Process (BP) chemotaxis 6.193e-11 Highly Informative Direct
Biological Process (BP) nucleoside monophosphate catabolic process 3.705e-09 Highly Informative Direct
Biological Process (BP) purine ribonucleoside monophosphate metabolic process 1.027e-08 Highly Informative Direct
Biological Process (BP) neuromuscular process 4.809e-08 Highly Informative Direct
Biological Process (BP) ribonucleoside triphosphate catabolic process 4.822e-08 Highly Informative Direct
Biological Process (BP) purine nucleoside triphosphate catabolic process 5.206e-08 Highly Informative Direct
Biological Process (BP) purine ribonucleoside catabolic process 6.816e-08 Highly Informative Direct
Biological Process (BP) purine ribonucleotide catabolic process 7.634e-08 Highly Informative Direct
Biological Process (BP) purine ribonucleoside triphosphate metabolic process 8.005e-08 Highly Informative Direct
Biological Process (BP) exocytosis 3.601e-07 Highly Informative Direct
Biological Process (BP) cell projection assembly 8.278e-07 Highly Informative Direct
Biological Process (BP) retina development in camera-type eye 8.313e-07 Highly Informative Direct
Biological Process (BP) telencephalon development 1.26e-06 Highly Informative Direct
Biological Process (BP) female gamete generation 3.48e-06 Highly Informative Direct
Biological Process (BP) spermatogenesis 5.334e-06 Highly Informative Direct
Biological Process (BP) cytoskeleton-dependent intracellular transport 1.157e-05 Highly Informative Direct
Biological Process (BP) regulation of reproductive process 4.192e-05 Highly Informative Direct
Biological Process (BP) microtubule-based movement 0.04741 Highly Informative Inherited
Biological Process (BP) neuron projection development 0.866 Highly Informative Inherited
Biological Process (BP) cell part morphogenesis 0.8723 Highly Informative Inherited
Biological Process (BP) muscle fiber development 0.8907 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.3997 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.05832 Highly Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.002916 Highly Informative Inherited
Biological Process (BP) epithelial cell development 0.04674 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 0.06748 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 1.435e-07 Least Informative Direct
Molecular Function (MF) binding 7.614e-07 Least Informative Direct
Molecular Function (MF) anion binding 0.01596 Moderately Informative Inherited
Molecular Function (MF) nucleoside-triphosphatase activity 6.053e-15 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 8.213e-10 Informative Direct
Molecular Function (MF) purine ribonucleoside binding 1.307e-09 Informative Direct
Molecular Function (MF) nucleotide binding 2.865e-08 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 1.149e-07 Informative Direct
Molecular Function (MF) ATP binding 2.907e-11 Highly Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) protein complex 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 5.068e-12 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.02143 Least Informative Inherited
Cellular Component (CC) cytoskeleton 2.632e-11 Moderately Informative Direct
Cellular Component (CC) cell projection 6.191e-11 Moderately Informative Direct
Cellular Component (CC) actin cytoskeleton 0 Informative Direct
Cellular Component (CC) contractile fiber part 3.516e-07 Informative Direct
Cellular Component (CC) cell cortex 0 Informative Direct
Cellular Component (CC) neuron projection 0.6907 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) cell body 1.474e-14 Highly Informative Direct
Cellular Component (CC) growth cone 1.403e-05 Highly Informative Direct
Cellular Component (CC) spindle 0.0002781 Highly Informative Direct
Cellular Component (CC) dendrite 0.002275 Highly Informative Inherited

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.000164Least InformativeDirect
Biological processCell cycle7.168e-07Moderately InformativeDirect
Biological processProtein transport2.533e-05Moderately InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Molecular functionCalmodulin-binding0InformativeDirect
Molecular functionActin-binding0InformativeDirect
Post-translational modificationMyosin0Highly InformativeDirect
Post-translational modificationPhosphoprotein1.228e-08Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR008989 SSF50084 Protein matches
Abstract

Myosin is a molecular motor that undergoes ATP-driven conformational changes during force production and motility. The S1 fragment myosin head consists of both the globular motor domain, containing the ATP- and actin-binding sites, and the lever arm, which amplifies small conformational changes in the motor domain into larger motions by which myosin moves actin. The motor domain contains four major subdomains linked by three single-stranded joints: the N-terminal subdomain, the upper 50-kDa subdomain, the lower 50-kDa subdomain, and the C-terminal converter subdomain [PubMed11016966]. The N-terminal subdomain has an SH3-like partly opened beta barrel topology, with the last strand being interrupted by a 3-10 helical turn. The N-terminal and upper 50-kDa subdomains together form the nucleotide-binding pocket. The binding of specific nucleotides alters the structural state of the myosin head during the contractile cycle.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 6 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Myosin S1 fragment, N-terminal domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 6 hidden Markov models representing the Myosin S1 fragment, N-terminal domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]