SUPERFAMILY 1.75 HMM library and genome assignments server

Myosin S1 fragment, N-terminal domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   SH3-like barrel [ 50036] (21)
Superfamily:   Myosin S1 fragment, N-terminal domain [ 50084]
Families:   Myosin S1 fragment, N-terminal domain [ 50085]


Superfamily statistics
Genomes (304) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 536 589 0
Proteins 536 588 0


Functional annotation
General category Processes_IC
Detailed category Cell motility

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular component organization or biogenesis0.0000081150Least InformativeDirect
Biological Process (BP)developmental process0.00014180.0000000000001271Least InformativeDirect
Biological Process (BP)multicellular organismal process0.00034430.00000001438Least InformativeDirect
Biological Process (BP)single-organism cellular process0.0013070.000001068Least InformativeInherited
Biological Process (BP)tissue development0.00000010550.00001646Moderately InformativeDirect
Biological Process (BP)anatomical structure morphogenesis0.00000089150.000002605Moderately InformativeDirect
Biological Process (BP)cellular component biogenesis0.081420.01335Moderately InformativeInherited
Biological Process (BP)organelle organization0.0044550.00000000003328Moderately InformativeInherited
Biological Process (BP)cell differentiation0.0000024381Moderately InformativeInherited
Biological Process (BP)organ development0.0000035660.03028Moderately InformativeInherited
Biological Process (BP)system process0.0021180.0002089Moderately InformativeInherited
Biological Process (BP)actin filament-based process0.0000000000042430InformativeDirect
Biological Process (BP)organelle assembly0.0000000078360.00000006797InformativeDirect
Biological Process (BP)cellular component movement0.00000064630InformativeDirect
Biological Process (BP)cytoskeleton organization0.00000080490.00009196InformativeDirect
Biological Process (BP)muscle structure development0.0000059960.00000005596InformativeDirect
Biological Process (BP)anatomical structure formation involved in morphogenesis0.00017610.000000009065InformativeDirect
Biological Process (BP)cellular component morphogenesis0.00023190.00000009424InformativeDirect
Biological Process (BP)muscle tissue development0.00024350.000001386InformativeDirect
Biological Process (BP)cardiovascular system development0.0047940.00002723InformativeInherited
Biological Process (BP)muscle system process0.00066290.006602InformativeInherited
Biological Process (BP)embryo development ending in birth or egg hatching0.0000025510.1695InformativeInherited
Biological Process (BP)actomyosin structure organization0.000000000010590.000000021Highly InformativeDirect
Biological Process (BP)actin filament-based movement0.00000010060.000000000001988Highly InformativeDirect
Biological Process (BP)cellular component assembly involved in morphogenesis0.0000011920.00000000001516Highly InformativeDirect
Biological Process (BP)cardiocyte differentiation0.0000067050.00000000000009575Highly InformativeDirect
Biological Process (BP)muscle fiber development0.000000000015890.8907Highly InformativeInherited
Biological Process (BP)cardiac muscle tissue development0.005560.000000007866Highly InformativeInherited
Molecular Function (MF)hydrolase activity0.0012820.0000001435Least InformativeInherited
Molecular Function (MF)nucleoside-triphosphatase activity0.0000015420.000000000000006053InformativeDirect
Cellular Component (CC)intracellular non-membrane-bounded organelle00Least InformativeDirect
Cellular Component (CC)protein complex0.000000064280Least InformativeDirect
Cellular Component (CC)cytoplasmic part00.02143Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.0011190.000000000005068Least InformativeInherited
Cellular Component (CC)cytoskeleton0.0062230.00000000002632Moderately InformativeInherited
Cellular Component (CC)actin cytoskeleton00InformativeDirect
Cellular Component (CC)contractile fiber part0.0000000000031550.0000003516InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) developmental process 0.0000000000001271 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.00000001438 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.000001068 Least Informative Direct
Biological Process (BP) localization 0.00000000213 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.2086 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.01863 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.01183 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.006981 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.05783 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.04492 Least Informative Inherited
Biological Process (BP) response to stimulus 0.001268 Least Informative Inherited
Biological Process (BP) tissue development 0.00001646 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.000002605 Moderately Informative Direct
Biological Process (BP) system process 0.0002089 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.0009483 Moderately Informative Direct
Biological Process (BP) organelle organization 0.00000000003328 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.000000006342 Moderately Informative Direct
Biological Process (BP) cellular localization 0.00000002982 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.00000007027 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.00006236 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0.0001086 Moderately Informative Direct
Biological Process (BP) reproduction 0.0001226 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0.0001416 Moderately Informative Direct
Biological Process (BP) cellular component biogenesis 0.01335 Moderately Informative Inherited
Biological Process (BP) organ development 0.03028 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.02394 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.0439 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.005963 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.002488 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.001135 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.1899 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.7416 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.01467 Moderately Informative Inherited
Biological Process (BP) actin filament-based process 0 Informative Direct
Biological Process (BP) organelle assembly 0.00000006797 Informative Direct
Biological Process (BP) cellular component movement 0 Informative Direct
Biological Process (BP) cytoskeleton organization 0.00009196 Informative Direct
Biological Process (BP) muscle structure development 0.00000005596 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.000000009065 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.00000009424 Informative Direct
Biological Process (BP) muscle tissue development 0.000001386 Informative Direct
Biological Process (BP) cardiovascular system development 0.00002723 Informative Direct
Biological Process (BP) generation of neurons 0.000000000001358 Informative Direct
Biological Process (BP) locomotion 0.000000001053 Informative Direct
Biological Process (BP) organelle localization 0.000000005172 Informative Direct
Biological Process (BP) nucleoside monophosphate metabolic process 0.00000001568 Informative Direct
Biological Process (BP) cellular membrane organization 0.00000002924 Informative Direct
Biological Process (BP) secretion by cell 0.00000005722 Informative Direct
Biological Process (BP) nucleoside triphosphate metabolic process 0.0000001278 Informative Direct
Biological Process (BP) organophosphate catabolic process 0.0000002049 Informative Direct
Biological Process (BP) purine ribonucleoside metabolic process 0.0000002882 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 0.0000004231 Informative Direct
Biological Process (BP) purine ribonucleotide metabolic process 0.0000004527 Informative Direct
Biological Process (BP) response to wounding 0.0000008326 Informative Direct
Biological Process (BP) cell cycle process 0.000001708 Informative Direct
Biological Process (BP) organonitrogen compound catabolic process 0.000006183 Informative Direct
Biological Process (BP) sensory organ development 0.000009296 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.00001058 Informative Direct
Biological Process (BP) cell projection organization 0.000014 Informative Direct
Biological Process (BP) nucleobase-containing compound catabolic process 0.00001887 Informative Direct
Biological Process (BP) localization of cell 0.0009886 Informative Direct
Biological Process (BP) mitotic cell cycle 0.0009978 Informative Direct
Biological Process (BP) regulation of cell development 0.03943 Informative Inherited
Biological Process (BP) microtubule-based process 0.001021 Informative Inherited
Biological Process (BP) central nervous system development 0.05521 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.1447 Informative Inherited
Biological Process (BP) single organism reproductive process 0.03784 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.128 Informative Inherited
Biological Process (BP) sexual reproduction 0.2343 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.002406 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.14 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) muscle system process 0.006602 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.00142 Informative Inherited
Biological Process (BP) protein transport 0.02473 Informative Inherited
Biological Process (BP) organ morphogenesis 0.2321 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.1695 Informative Inherited
Biological Process (BP) actomyosin structure organization 0.000000021 Highly Informative Direct
Biological Process (BP) actin filament-based movement 0.000000000001988 Highly Informative Direct
Biological Process (BP) cellular component assembly involved in morphogenesis 0.00000000001516 Highly Informative Direct
Biological Process (BP) cardiocyte differentiation 0.00000000000009575 Highly Informative Direct
Biological Process (BP) cardiac muscle tissue development 0.000000007866 Highly Informative Direct
Biological Process (BP) wound healing 0.000000000002613 Highly Informative Direct
Biological Process (BP) cell division 0.000000000004739 Highly Informative Direct
Biological Process (BP) chemotaxis 0.00000000006193 Highly Informative Direct
Biological Process (BP) nucleoside monophosphate catabolic process 0.000000003705 Highly Informative Direct
Biological Process (BP) purine ribonucleoside monophosphate metabolic process 0.00000001027 Highly Informative Direct
Biological Process (BP) neuromuscular process 0.00000004809 Highly Informative Direct
Biological Process (BP) ribonucleoside triphosphate catabolic process 0.00000004822 Highly Informative Direct
Biological Process (BP) purine nucleoside triphosphate catabolic process 0.00000005206 Highly Informative Direct
Biological Process (BP) purine ribonucleoside catabolic process 0.00000006816 Highly Informative Direct
Biological Process (BP) purine ribonucleotide catabolic process 0.00000007634 Highly Informative Direct
Biological Process (BP) purine ribonucleoside triphosphate metabolic process 0.00000008005 Highly Informative Direct
Biological Process (BP) exocytosis 0.0000003601 Highly Informative Direct
Biological Process (BP) cell projection assembly 0.0000008278 Highly Informative Direct
Biological Process (BP) retina development in camera-type eye 0.0000008313 Highly Informative Direct
Biological Process (BP) telencephalon development 0.00000126 Highly Informative Direct
Biological Process (BP) female gamete generation 0.00000348 Highly Informative Direct
Biological Process (BP) spermatogenesis 0.000005334 Highly Informative Direct
Biological Process (BP) cytoskeleton-dependent intracellular transport 0.00001157 Highly Informative Direct
Biological Process (BP) regulation of reproductive process 0.00004192 Highly Informative Direct
Biological Process (BP) microtubule-based movement 0.04741 Highly Informative Inherited
Biological Process (BP) neuron projection development 0.866 Highly Informative Inherited
Biological Process (BP) cell part morphogenesis 0.8723 Highly Informative Inherited
Biological Process (BP) muscle fiber development 0.8907 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.3997 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.05832 Highly Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.002916 Highly Informative Inherited
Biological Process (BP) epithelial cell development 0.04674 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 0.06748 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0.0000001435 Least Informative Direct
Molecular Function (MF) binding 0.0000007614 Least Informative Direct
Molecular Function (MF) anion binding 0.01596 Moderately Informative Inherited
Molecular Function (MF) nucleoside-triphosphatase activity 0.000000000000006053 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.0000000008213 Informative Direct
Molecular Function (MF) purine ribonucleoside binding 0.000000001307 Informative Direct
Molecular Function (MF) nucleotide binding 0.00000002865 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0.0000001149 Informative Direct
Molecular Function (MF) ATP binding 0.00000000002907 Highly Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) protein complex 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.000000000005068 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.02143 Least Informative Inherited
Cellular Component (CC) cytoskeleton 0.00000000002632 Moderately Informative Direct
Cellular Component (CC) cell projection 0.00000000006191 Moderately Informative Direct
Cellular Component (CC) actin cytoskeleton 0 Informative Direct
Cellular Component (CC) contractile fiber part 0.0000003516 Informative Direct
Cellular Component (CC) cell cortex 0 Informative Direct
Cellular Component (CC) neuron projection 0.6907 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) cell body 0.00000000000001474 Highly Informative Direct
Cellular Component (CC) growth cone 0.00001403 Highly Informative Direct
Cellular Component (CC) spindle 0.0002781 Highly Informative Direct
Cellular Component (CC) dendrite 0.002275 Highly Informative Inherited

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.000164Least InformativeDirect
Biological processCell cycle0.0000007168Moderately InformativeDirect
Biological processProtein transport0.00002533Moderately InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Molecular functionCalmodulin-binding0InformativeDirect
Molecular functionActin-binding0InformativeDirect
Post-translational modificationMyosin0Highly InformativeDirect
Post-translational modificationPhosphoprotein0.00000001228Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR008989 SSF50084 Protein matches
Abstract

Myosin is a molecular motor that undergoes ATP-driven conformational changes during force production and motility. The S1 fragment myosin head consists of both the globular motor domain, containing the ATP- and actin-binding sites, and the lever arm, which amplifies small conformational changes in the motor domain into larger motions by which myosin moves actin. The motor domain contains four major subdomains linked by three single-stranded joints: the N-terminal subdomain, the upper 50-kDa subdomain, the lower 50-kDa subdomain, and the C-terminal converter subdomain [PubMed11016966]. The N-terminal subdomain has an SH3-like partly opened beta barrel topology, with the last strand being interrupted by a 3-10 helical turn. The N-terminal and upper 50-kDa subdomains together form the nucleotide-binding pocket. The binding of specific nucleotides alters the structural state of the myosin head during the contractile cycle.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 6 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Myosin S1 fragment, N-terminal domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 6 hidden Markov models representing the Myosin S1 fragment, N-terminal domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]