SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.


Myosin S1 fragment, N-terminal domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   SH3-like barrel [ 50036] (21)
Superfamily:   Myosin S1 fragment, N-terminal domain [ 50084]
Families:   Myosin S1 fragment, N-terminal domain [ 50085]


Superfamily statistics
Genomes (304) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 536 589 0
Proteins 536 588 0


Functional annotation
General category Processes_IC
Detailed category Cell motility

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular component organization or biogenesis0.00029710.0000000003267Least InformativeDirect
Biological Process (BP)single-organism cellular process0.17870.06229Least InformativeInherited
Biological Process (BP)actin filament-based process0.000000019860InformativeDirect
Cellular Component (CC)non-membrane-bounded organelle0.000021020.00000000001361Least InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 0.0000000003267 Least Informative Direct
Biological Process (BP) biological regulation 0.0611 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.06229 Least Informative Inherited
Biological Process (BP) regulation of developmental process 0.00000371 Moderately Informative Direct
Biological Process (BP) cellular localization 0.00001868 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.00003363 Moderately Informative Direct
Biological Process (BP) cellular developmental process 0.0001064 Moderately Informative Direct
Biological Process (BP) organelle organization 0.0001816 Moderately Informative Direct
Biological Process (BP) reproduction 0.0001883 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.000575 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.3531 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.001478 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.005139 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.02342 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.02447 Moderately Informative Inherited
Biological Process (BP) system development 0.3345 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.3339 Moderately Informative Inherited
Biological Process (BP) actin filament-based process 0 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0.00000001359 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.0000005839 Informative Direct
Biological Process (BP) regulation of cell differentiation 0.00000133 Informative Direct
Biological Process (BP) microtubule-based process 0.000001645 Informative Direct
Biological Process (BP) regulation of cellular localization 0.000002662 Informative Direct
Biological Process (BP) mitotic cell cycle 0.000007978 Informative Direct
Biological Process (BP) single-organism intracellular transport 0.00001051 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.00001284 Informative Direct
Biological Process (BP) generation of neurons 0.00008521 Informative Direct
Biological Process (BP) cell cycle process 0.002176 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.005825 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.01124 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.001692 Informative Inherited
Biological Process (BP) cell development 0.004393 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.07971 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.009996 Informative Inherited
Biological Process (BP) embryo development 0.02625 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.05098 Informative Inherited
Biological Process (BP) multi-organism reproductive process 0.01521 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.03871 Informative Inherited
Biological Process (BP) single organism reproductive process 0.01336 Informative Inherited
Biological Process (BP) establishment of organelle localization 0.0000000002624 Highly Informative Direct
Biological Process (BP) spermatogenesis 0.0000002618 Highly Informative Direct
Biological Process (BP) female gamete generation 0.0000003779 Highly Informative Direct
Biological Process (BP) regulation of reproductive process 0.000001353 Highly Informative Direct
Biological Process (BP) positive regulation of cellular component biogenesis 0.000002023 Highly Informative Direct
Biological Process (BP) cellular component assembly involved in morphogenesis 0.000002496 Highly Informative Direct
Biological Process (BP) cell division 0.00002378 Highly Informative Direct
Biological Process (BP) microtubule-based movement 0.0002892 Highly Informative Direct
Biological Process (BP) positive regulation of cell development 0.004237 Highly Informative Inherited
Biological Process (BP) muscle structure development 0.004558 Highly Informative Inherited
Biological Process (BP) neuron development 0.2331 Highly Informative Inherited
Biological Process (BP) germ cell development 0.02211 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.01365 Highly Informative Inherited
Biological Process (BP) sensory organ morphogenesis 0.003013 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0.000004435 Least Informative Direct
Molecular Function (MF) binding 0.001802 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.00000000005617 Moderately Informative Direct
Molecular Function (MF) anion binding 0.000001232 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.000003548 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0.00001355 Moderately Informative Direct
Molecular Function (MF) protein binding 0.00004516 Moderately Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.0000000009869 Informative Direct
Molecular Function (MF) ribonucleoside binding 0.000000001628 Informative Direct
Molecular Function (MF) purine nucleoside binding 0.000000001662 Informative Direct
Molecular Function (MF) purine nucleotide binding 0.000000002904 Informative Direct
Molecular Function (MF) ribonucleotide binding 0.00000000347 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0.00000000923 Informative Direct
Molecular Function (MF) ATPase activity 0.1582 Informative Inherited
Molecular Function (MF) ATP binding 0.0000000000591 Highly Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0.00000000001361 Least Informative Direct
Cellular Component (CC) protein complex 0.00000000001867 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.000004811 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.4999 Least Informative Inherited
Cellular Component (CC) cell projection 0.000002536 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.000007696 Moderately Informative Direct
Cellular Component (CC) actin cytoskeleton 0 Informative Direct
Cellular Component (CC) cytoplasmic region 0.0000005089 Informative Direct
Cellular Component (CC) neuronal cell body 0.000000004965 Highly Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.0001635Least InformativeDirect
Biological processCell cycle0.0000007305Moderately InformativeDirect
Biological processProtein transport0.00002834Moderately InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Molecular functionCalmodulin-binding0InformativeDirect
Molecular functionActin-binding0InformativeDirect
Post-translational modificationMyosin0Highly InformativeDirect
Post-translational modificationPhosphoprotein0.0000001021Least InformativeDirect
Post-translational modificationMethylation0.00000003182Moderately InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR008989 SSF50084 Protein matches
Abstract

Myosin is a molecular motor that undergoes ATP-driven conformational changes during force production and motility. The S1 fragment myosin head consists of both the globular motor domain, containing the ATP- and actin-binding sites, and the lever arm, which amplifies small conformational changes in the motor domain into larger motions by which myosin moves actin. The motor domain contains four major subdomains linked by three single-stranded joints: the N-terminal subdomain, the upper 50-kDa subdomain, the lower 50-kDa subdomain, and the C-terminal converter subdomain [PubMed11016966]. The N-terminal subdomain has an SH3-like partly opened beta barrel topology, with the last strand being interrupted by a 3-10 helical turn. The N-terminal and upper 50-kDa subdomains together form the nucleotide-binding pocket. The binding of specific nucleotides alters the structural state of the myosin head during the contractile cycle.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 6 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Myosin S1 fragment, N-terminal domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 6 hidden Markov models representing the Myosin S1 fragment, N-terminal domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]