SUPERFAMILY 1.75 HMM library and genome assignments server

Myosin S1 fragment, N-terminal domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   SH3-like barrel [ 50036] (21)
Superfamily:   Myosin S1 fragment, N-terminal domain [ 50084]
Families:   Myosin S1 fragment, N-terminal domain [ 50085]


Superfamily statistics
Genomes (304) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 536 589 0
Proteins 536 588 0


Functional annotation
General category Processes_IC
Detailed category Cell motility

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process0.0002980.000000006242Least InformativeDirect
Biological Process (BP)developmental process0.00014440.0000000000001332Least InformativeDirect
Biological Process (BP)cellular component organization or biogenesis0.0000086260Least InformativeDirect
Biological Process (BP)single-organism cellular process0.0067480.00003852Least InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.00000090360.000002586Moderately InformativeDirect
Biological Process (BP)single-organism organelle organization0.00023580.00000000983Moderately InformativeDirect
Biological Process (BP)tissue development0.000000088090.01503Moderately InformativeInherited
Biological Process (BP)cell differentiation0.0000026231Moderately InformativeInherited
Biological Process (BP)organ development0.0000034280.02605Moderately InformativeInherited
Biological Process (BP)cellular component biogenesis0.077390.01095Moderately InformativeInherited
Biological Process (BP)cellular component movement0.00000013890InformativeDirect
Biological Process (BP)cytoskeleton organization0.00000080750.00005048InformativeDirect
Biological Process (BP)actin filament-based process0.0000000000041920InformativeDirect
Biological Process (BP)cellular component morphogenesis0.00042980.0000005923InformativeDirect
Biological Process (BP)anatomical structure formation involved in morphogenesis0.00017380.000000009615InformativeDirect
Biological Process (BP)muscle structure development0.0000031190.0000000117InformativeDirect
Biological Process (BP)organelle assembly0.0000000082790.00000006936InformativeDirect
Biological Process (BP)cardiovascular system development0.0048940.00002878InformativeInherited
Biological Process (BP)muscle system process0.0015070.03149InformativeInherited
Biological Process (BP)embryo development ending in birth or egg hatching0.0000026530.1701InformativeInherited
Biological Process (BP)in utero embryonic development0.00000037910.0000000000001316Highly InformativeDirect
Biological Process (BP)cellular component assembly involved in morphogenesis0.00000046410.000000000007332Highly InformativeDirect
Biological Process (BP)actin filament-based movement0.000000095080.000000000001877Highly InformativeDirect
Biological Process (BP)actomyosin structure organization0.00000000001050.00000001699Highly InformativeDirect
Biological Process (BP)cardiocyte differentiation0.0000063080.00000000000008202Highly InformativeDirect
Biological Process (BP)cardiac muscle tissue development0.013060.00000006695Highly InformativeInherited
Biological Process (BP)muscle fiber development0.000000000002390.1484Highly InformativeInherited
Molecular Function (MF)hydrolase activity0.0012920.0000001474Least InformativeInherited
Molecular Function (MF)nucleoside-triphosphatase activity0.0000015380.000000000000006187InformativeDirect
Cellular Component (CC)non-membrane-bounded organelle00Least InformativeDirect
Cellular Component (CC)protein complex0.000000062760Least InformativeDirect
Cellular Component (CC)cytoplasmic part00.02432Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.0011340.000000000003508Least InformativeInherited
Cellular Component (CC)cytoskeleton0.0047380.00000000002341Moderately InformativeInherited
Cellular Component (CC)actin cytoskeleton00InformativeDirect
Cellular Component (CC)contractile fiber part0.0000000000032670.0000003911InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0.000000006242 Least Informative Direct
Biological Process (BP) developmental process 0.0000000000001332 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.00003852 Least Informative Direct
Biological Process (BP) localization 0.0000000003433 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.0616 Least Informative Inherited
Biological Process (BP) positive regulation of biological process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.78 Least Informative Inherited
Biological Process (BP) response to stimulus 0.00127 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.2348 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.01277 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.02007 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.007618 Least Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.000002586 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0.0001354 Moderately Informative Direct
Biological Process (BP) single-organism catabolic process 0.0002147 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.000000006299 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.0000001231 Moderately Informative Direct
Biological Process (BP) cellular localization 0.0000006417 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.0008404 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0.0001798 Moderately Informative Direct
Biological Process (BP) single-organism organelle organization 0.00000000983 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.002555 Moderately Informative Inherited
Biological Process (BP) organ development 0.02605 Moderately Informative Inherited
Biological Process (BP) tissue development 0.01503 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.08118 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.04726 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.001199 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.01603 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.001165 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.01095 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.0166 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.008007 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.004117 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) reproductive process 0.001279 Moderately Informative Inherited
Biological Process (BP) mitotic cell cycle 0.0000000000005125 Informative Direct
Biological Process (BP) cellular component movement 0 Informative Direct
Biological Process (BP) cytoskeleton organization 0.00005048 Informative Direct
Biological Process (BP) microtubule-based process 0.00007522 Informative Direct
Biological Process (BP) sensory organ development 0.000005042 Informative Direct
Biological Process (BP) cell proliferation 0.00002356 Informative Direct
Biological Process (BP) nucleoside monophosphate metabolic process 0.0000000373 Informative Direct
Biological Process (BP) nucleoside triphosphate metabolic process 0.0000002436 Informative Direct
Biological Process (BP) purine ribonucleotide metabolic process 0.0000007764 Informative Direct
Biological Process (BP) cell cycle process 0.0000006103 Informative Direct
Biological Process (BP) actin filament-based process 0 Informative Direct
Biological Process (BP) cell projection organization 0.00000359 Informative Direct
Biological Process (BP) secretion by cell 0.00000001458 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.0000005923 Informative Direct
Biological Process (BP) nucleobase-containing compound catabolic process 0.00001696 Informative Direct
Biological Process (BP) locomotion 0.000000001037 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.0000131 Informative Direct
Biological Process (BP) single-organism membrane organization 0.00000001049 Informative Direct
Biological Process (BP) purine ribonucleoside metabolic process 0.0000005117 Informative Direct
Biological Process (BP) organophosphate catabolic process 0.0000002021 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.000000009615 Informative Direct
Biological Process (BP) generation of neurons 0.000000000001417 Informative Direct
Biological Process (BP) cell division 0.0000000063 Informative Direct
Biological Process (BP) organelle localization 0.000000001533 Informative Direct
Biological Process (BP) muscle structure development 0.0000000117 Informative Direct
Biological Process (BP) organelle assembly 0.00000006936 Informative Direct
Biological Process (BP) cardiovascular system development 0.00002878 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 0.0000004302 Informative Direct
Biological Process (BP) organonitrogen compound catabolic process 0.000006198 Informative Direct
Biological Process (BP) positive regulation of developmental process 0.04795 Informative Inherited
Biological Process (BP) neurological system process 0.6646 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.09802 Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.002186 Informative Inherited
Biological Process (BP) single-organism cellular localization 0.009043 Informative Inherited
Biological Process (BP) regulation of cell development 0.02735 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.01022 Informative Inherited
Biological Process (BP) organ morphogenesis 0.1726 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.005478 Informative Inherited
Biological Process (BP) single-organism intracellular transport 0.297 Informative Inherited
Biological Process (BP) central nervous system development 0.05923 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.1336 Informative Inherited
Biological Process (BP) single organism reproductive process 0.01342 Informative Inherited
Biological Process (BP) sexual reproduction 0.7074 Informative Inherited
Biological Process (BP) muscle system process 0.03149 Informative Inherited
Biological Process (BP) localization of cell 0.001352 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.00257 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.1701 Informative Inherited
Biological Process (BP) cytokinesis 0 Highly Informative Direct
Biological Process (BP) in utero embryonic development 0.0000000000001316 Highly Informative Direct
Biological Process (BP) exocytosis 0.000000366 Highly Informative Direct
Biological Process (BP) chemotaxis 0.00000000006013 Highly Informative Direct
Biological Process (BP) plasma membrane organization 0.000001947 Highly Informative Direct
Biological Process (BP) spermatogenesis 0.000005375 Highly Informative Direct
Biological Process (BP) female gamete generation 0.00000345 Highly Informative Direct
Biological Process (BP) nucleoside monophosphate catabolic process 0.00000000364 Highly Informative Direct
Biological Process (BP) purine nucleoside triphosphate catabolic process 0.00000005137 Highly Informative Direct
Biological Process (BP) purine ribonucleotide catabolic process 0.00000007532 Highly Informative Direct
Biological Process (BP) ribonucleoside triphosphate catabolic process 0.0000000476 Highly Informative Direct
Biological Process (BP) cellular component assembly involved in morphogenesis 0.000000000007332 Highly Informative Direct
Biological Process (BP) telencephalon development 0.0000015 Highly Informative Direct
Biological Process (BP) cell projection assembly 0.000000735 Highly Informative Direct
Biological Process (BP) actin filament-based movement 0.000000000001877 Highly Informative Direct
Biological Process (BP) actomyosin structure organization 0.00000001699 Highly Informative Direct
Biological Process (BP) cardiocyte differentiation 0.00000000000008202 Highly Informative Direct
Biological Process (BP) wound healing 0.000000000002521 Highly Informative Direct
Biological Process (BP) regulation of multi-organism process 0.0001707 Highly Informative Direct
Biological Process (BP) positive regulation of cellular component biogenesis 0.0000006122 Highly Informative Direct
Biological Process (BP) purine ribonucleoside catabolic process 0.00000006724 Highly Informative Direct
Biological Process (BP) cardiac muscle tissue development 0.00000006695 Highly Informative Direct
Biological Process (BP) neuromuscular process 0.000002361 Highly Informative Direct
Biological Process (BP) retina development in camera-type eye 0.0000008084 Highly Informative Direct
Biological Process (BP) regulation of reproductive process 0.00002072 Highly Informative Direct
Biological Process (BP) neuron projection development 0.8611 Highly Informative Inherited
Biological Process (BP) cell projection morphogenesis 0.2885 Highly Informative Inherited
Biological Process (BP) muscle fiber development 0.1484 Highly Informative Inherited
Biological Process (BP) microtubule-based movement 0.01751 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.3746 Highly Informative Inherited
Biological Process (BP) germ cell development 0.109 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.06935 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 0.06746 Highly Informative Inherited
Molecular Function (MF) binding 0.0000008945 Least Informative Direct
Molecular Function (MF) hydrolase activity 0.0000001474 Least Informative Direct
Molecular Function (MF) small molecule binding 0.0001198 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.0000448 Moderately Informative Direct
Molecular Function (MF) anion binding 0.016 Moderately Informative Inherited
Molecular Function (MF) nucleotide binding 0.00000002881 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0.0000001127 Informative Direct
Molecular Function (MF) nucleoside-triphosphatase activity 0.000000000000006187 Informative Direct
Molecular Function (MF) purine ribonucleoside binding 0.000000001316 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.0000000008317 Informative Direct
Molecular Function (MF) ATP binding 0.00000000002921 Highly Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) protein complex 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.000000000003508 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.02432 Least Informative Inherited
Cellular Component (CC) cytoskeleton 0.00000000002341 Moderately Informative Direct
Cellular Component (CC) cell projection 0.0000000000904 Moderately Informative Direct
Cellular Component (CC) cell cortex 0 Informative Direct
Cellular Component (CC) actin cytoskeleton 0 Informative Direct
Cellular Component (CC) contractile fiber part 0.0000003911 Informative Direct
Cellular Component (CC) synapse 0.000001335 Informative Direct
Cellular Component (CC) neuron projection 0.6315 Informative Inherited
Cellular Component (CC) growth cone 0.00001125 Highly Informative Direct
Cellular Component (CC) cell body 0.00000000000001464 Highly Informative Direct
Cellular Component (CC) dendrite 0.1611 Highly Informative Inherited

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.000164Least InformativeDirect
Biological processCell cycle0.0000007168Moderately InformativeDirect
Biological processProtein transport0.00002533Moderately InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Molecular functionCalmodulin-binding0InformativeDirect
Molecular functionActin-binding0InformativeDirect
Post-translational modificationMyosin0Highly InformativeDirect
Post-translational modificationPhosphoprotein0.00000001228Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR008989 SSF50084 Protein matches
Abstract

Myosin is a molecular motor that undergoes ATP-driven conformational changes during force production and motility. The S1 fragment myosin head consists of both the globular motor domain, containing the ATP- and actin-binding sites, and the lever arm, which amplifies small conformational changes in the motor domain into larger motions by which myosin moves actin. The motor domain contains four major subdomains linked by three single-stranded joints: the N-terminal subdomain, the upper 50-kDa subdomain, the lower 50-kDa subdomain, and the C-terminal converter subdomain [PubMed11016966]. The N-terminal subdomain has an SH3-like partly opened beta barrel topology, with the last strand being interrupted by a 3-10 helical turn. The N-terminal and upper 50-kDa subdomains together form the nucleotide-binding pocket. The binding of specific nucleotides alters the structural state of the myosin head during the contractile cycle.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 6 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Myosin S1 fragment, N-terminal domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 6 hidden Markov models representing the Myosin S1 fragment, N-terminal domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]