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Myosin S1 fragment, N-terminal domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   SH3-like barrel [ 50036] (21)
Superfamily:   Myosin S1 fragment, N-terminal domain [ 50084]
Families:   Myosin S1 fragment, N-terminal domain [ 50085]


Superfamily statistics
Genomes (303) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 535 589 0
Proteins 535 588 0


Functional annotation
General category Processes_IC
Detailed category Cell motility

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular component organization or biogenesis0.0000078460Least InformativeDirect
Biological Process (BP)developmental process0.00014010.0000000000001268Least InformativeDirect
Biological Process (BP)multicellular organismal process0.00034160.00000001417Least InformativeDirect
Biological Process (BP)single-organism cellular process0.0012980.000001037Least InformativeInherited
Biological Process (BP)tissue development0.00000010390.00001611Moderately InformativeDirect
Biological Process (BP)anatomical structure morphogenesis0.00000086520.00000255Moderately InformativeDirect
Biological Process (BP)single-organism developmental process0.00094970.0000007127Moderately InformativeDirect
Biological Process (BP)cellular component biogenesis0.081250.01295Moderately InformativeInherited
Biological Process (BP)organelle organization0.0044270.00000000003311Moderately InformativeInherited
Biological Process (BP)cell differentiation0.0000024391Moderately InformativeInherited
Biological Process (BP)organ development0.0000034760.03028Moderately InformativeInherited
Biological Process (BP)system process0.0020690.0002007Moderately InformativeInherited
Biological Process (BP)actin filament-based process0.0000000000042550InformativeDirect
Biological Process (BP)organelle assembly0.0000000072420.00000006367InformativeDirect
Biological Process (BP)cellular component movement0.00000064570InformativeDirect
Biological Process (BP)cytoskeleton organization0.00000081320.00009487InformativeDirect
Biological Process (BP)muscle structure development0.0000056950.00000005379InformativeDirect
Biological Process (BP)anatomical structure formation involved in morphogenesis0.00017170.000000008268InformativeDirect
Biological Process (BP)muscle tissue development0.00022250.000001302InformativeDirect
Biological Process (BP)cellular component morphogenesis0.00022410.00000009706InformativeDirect
Biological Process (BP)cardiovascular system development0.0048360.00002763InformativeInherited
Biological Process (BP)muscle system process0.00068020.006735InformativeInherited
Biological Process (BP)embryo development ending in birth or egg hatching0.0000025570.1719InformativeInherited
Biological Process (BP)actomyosin structure organization0.00000000001060.00000002096Highly InformativeDirect
Biological Process (BP)actin filament-based movement0.000000099570.000000000001991Highly InformativeDirect
Biological Process (BP)cellular component assembly involved in morphogenesis0.0000010570.00000000001313Highly InformativeDirect
Biological Process (BP)cardiocyte differentiation0.0000067090.00000000000009864Highly InformativeDirect
Biological Process (BP)muscle fiber development0.000000000015940.8869Highly InformativeInherited
Biological Process (BP)cardiac muscle tissue development0.0057950.000000008119Highly InformativeInherited
Molecular Function (MF)hydrolase activity0.0012840.0000001444Least InformativeInherited
Molecular Function (MF)hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides0.0000033940.00000000000001898Moderately InformativeDirect
Molecular Function (MF)nucleoside-triphosphatase activity0.0000015510.000000000000006038InformativeDirect
Cellular Component (CC)intracellular non-membrane-bounded organelle00Least InformativeDirect
Cellular Component (CC)protein complex0.000000064710Least InformativeDirect
Cellular Component (CC)cytoplasmic part00.02114Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.0011130.000000000005121Least InformativeInherited
Cellular Component (CC)cytoskeleton0.0062050.00000000002515Moderately InformativeInherited
Cellular Component (CC)actin cytoskeleton00InformativeDirect
Cellular Component (CC)contractile fiber part0.0000000000032460.0000003611InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) developmental process 0.0000000000001268 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.00000001417 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.000001037 Least Informative Direct
Biological Process (BP) localization 0.000000001952 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.2068 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.01851 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.01174 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.006916 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.05741 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.04526 Least Informative Inherited
Biological Process (BP) response to stimulus 0.001233 Least Informative Inherited
Biological Process (BP) tissue development 0.00001611 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.00000255 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 0.0000007127 Moderately Informative Direct
Biological Process (BP) system process 0.0002007 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.0009104 Moderately Informative Direct
Biological Process (BP) organelle organization 0.00000000003311 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.000000005789 Moderately Informative Direct
Biological Process (BP) cellular localization 0.00000002899 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.00000006672 Moderately Informative Direct
Biological Process (BP) organonitrogen compound catabolic process 0.000006111 Moderately Informative Direct
Biological Process (BP) organic cyclic compound catabolic process 0.00002887 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.00006126 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0.0001073 Moderately Informative Direct
Biological Process (BP) reproduction 0.000121 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0.0001389 Moderately Informative Direct
Biological Process (BP) cellular component biogenesis 0.01295 Moderately Informative Inherited
Biological Process (BP) organ development 0.03028 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.02312 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.04312 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.006007 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.001123 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.1934 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.7507 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.01437 Moderately Informative Inherited
Biological Process (BP) actin filament-based process 0 Informative Direct
Biological Process (BP) organelle assembly 0.00000006367 Informative Direct
Biological Process (BP) cellular component movement 0 Informative Direct
Biological Process (BP) cytoskeleton organization 0.00009487 Informative Direct
Biological Process (BP) muscle structure development 0.00000005379 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.000000008268 Informative Direct
Biological Process (BP) muscle tissue development 0.000001302 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.00000009706 Informative Direct
Biological Process (BP) cardiovascular system development 0.00002763 Informative Direct
Biological Process (BP) generation of neurons 0.000000000001323 Informative Direct
Biological Process (BP) locomotion 0.000000001067 Informative Direct
Biological Process (BP) organelle localization 0.000000005358 Informative Direct
Biological Process (BP) nucleoside monophosphate metabolic process 0.00000001693 Informative Direct
Biological Process (BP) cellular membrane organization 0.00000002867 Informative Direct
Biological Process (BP) secretion by cell 0.00000005554 Informative Direct
Biological Process (BP) glycosyl compound catabolic process 0.0000001001 Informative Direct
Biological Process (BP) nucleoside triphosphate metabolic process 0.000000126 Informative Direct
Biological Process (BP) organophosphate catabolic process 0.000000201 Informative Direct
Biological Process (BP) purine ribonucleoside metabolic process 0.0000002852 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 0.0000004166 Informative Direct
Biological Process (BP) purine ribonucleotide metabolic process 0.0000004458 Informative Direct
Biological Process (BP) response to wounding 0.0000008485 Informative Direct
Biological Process (BP) cell cycle process 0.000001731 Informative Direct
Biological Process (BP) sensory organ development 0.000009164 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.0000105 Informative Direct
Biological Process (BP) cell projection organization 0.00001397 Informative Direct
Biological Process (BP) nucleobase-containing compound catabolic process 0.00001887 Informative Direct
Biological Process (BP) mitotic cell cycle 0.0009938 Informative Direct
Biological Process (BP) regulation of cell development 0.03787 Informative Inherited
Biological Process (BP) microtubule-based process 0.001037 Informative Inherited
Biological Process (BP) central nervous system development 0.05417 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.1465 Informative Inherited
Biological Process (BP) single organism reproductive process 0.03719 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.1279 Informative Inherited
Biological Process (BP) sexual reproduction 0.2294 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.002393 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.1376 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) muscle system process 0.006735 Informative Inherited
Biological Process (BP) localization of cell 0.001016 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.001498 Informative Inherited
Biological Process (BP) protein transport 0.02484 Informative Inherited
Biological Process (BP) organ morphogenesis 0.2315 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.1719 Informative Inherited
Biological Process (BP) actomyosin structure organization 0.00000002096 Highly Informative Direct
Biological Process (BP) actin filament-based movement 0.000000000001991 Highly Informative Direct
Biological Process (BP) cellular component assembly involved in morphogenesis 0.00000000001313 Highly Informative Direct
Biological Process (BP) cardiocyte differentiation 0.00000000000009864 Highly Informative Direct
Biological Process (BP) cardiac muscle tissue development 0.000000008119 Highly Informative Direct
Biological Process (BP) wound healing 0.000000000002484 Highly Informative Direct
Biological Process (BP) cell division 0.000000000004879 Highly Informative Direct
Biological Process (BP) chemotaxis 0.00000000006422 Highly Informative Direct
Biological Process (BP) nucleoside monophosphate catabolic process 0.000000004033 Highly Informative Direct
Biological Process (BP) ATP metabolic process 0.000000005831 Highly Informative Direct
Biological Process (BP) purine ribonucleoside triphosphate catabolic process 0.00000004738 Highly Informative Direct
Biological Process (BP) neuromuscular process 0.00000005082 Highly Informative Direct
Biological Process (BP) purine ribonucleoside catabolic process 0.00000006707 Highly Informative Direct
Biological Process (BP) purine ribonucleotide catabolic process 0.00000007516 Highly Informative Direct
Biological Process (BP) exocytosis 0.0000003405 Highly Informative Direct
Biological Process (BP) cell projection assembly 0.0000007449 Highly Informative Direct
Biological Process (BP) retina development in camera-type eye 0.0000008043 Highly Informative Direct
Biological Process (BP) telencephalon development 0.000001165 Highly Informative Direct
Biological Process (BP) female gamete generation 0.00000324 Highly Informative Direct
Biological Process (BP) spermatogenesis 0.000005117 Highly Informative Direct
Biological Process (BP) regulation of reproductive process 0.00004255 Highly Informative Direct
Biological Process (BP) microtubule-based movement 0.04742 Highly Informative Inherited
Biological Process (BP) neuron projection development 0.8728 Highly Informative Inherited
Biological Process (BP) cell part morphogenesis 0.8728 Highly Informative Inherited
Biological Process (BP) muscle fiber development 0.8869 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.4097 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.05884 Highly Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.002691 Highly Informative Inherited
Biological Process (BP) epithelial cell development 0.0459 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 0.06613 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0.0000001444 Least Informative Direct
Molecular Function (MF) binding 0.0000007084 Least Informative Direct
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.00000000000001898 Moderately Informative Direct
Molecular Function (MF) anion binding 0.01571 Moderately Informative Inherited
Molecular Function (MF) nucleoside-triphosphatase activity 0.000000000000006038 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.0000000008247 Informative Direct
Molecular Function (MF) purine ribonucleoside binding 0.000000001312 Informative Direct
Molecular Function (MF) nucleotide binding 0.00000002775 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0.0000001184 Informative Direct
Molecular Function (MF) ATP binding 0.00000000002903 Highly Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) protein complex 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.000000000005121 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.02114 Least Informative Inherited
Cellular Component (CC) cytoskeleton 0.00000000002515 Moderately Informative Direct
Cellular Component (CC) cell projection 0.00000000005375 Moderately Informative Direct
Cellular Component (CC) actin cytoskeleton 0 Informative Direct
Cellular Component (CC) contractile fiber part 0.0000003611 Informative Direct
Cellular Component (CC) cell cortex 0 Informative Direct
Cellular Component (CC) neuron projection 0.6778 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) cell body 0.00000000000001473 Highly Informative Direct
Cellular Component (CC) growth cone 0.0000146 Highly Informative Direct
Cellular Component (CC) spindle 0.0002763 Highly Informative Direct
Cellular Component (CC) dendrite 0.002345 Highly Informative Inherited

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.000164Least InformativeDirect
Biological processCell cycle0.0000007615Moderately InformativeDirect
Biological processProtein transport0.00002536Moderately InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Molecular functionCalmodulin-binding0InformativeDirect
Molecular functionActin-binding0InformativeDirect
Post-translational modificationMyosin0Highly InformativeDirect
Post-translational modificationPhosphoprotein0.00000001203Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR008989 SSF50084 Protein matches
Abstract

Myosin is a molecular motor that undergoes ATP-driven conformational changes during force production and motility. The S1 fragment myosin head consists of both the globular motor domain, containing the ATP- and actin-binding sites, and the lever arm, which amplifies small conformational changes in the motor domain into larger motions by which myosin moves actin. The motor domain contains four major subdomains linked by three single-stranded joints: the N-terminal subdomain, the upper 50-kDa subdomain, the lower 50-kDa subdomain, and the C-terminal converter subdomain [PubMed11016966]. The N-terminal subdomain has an SH3-like partly opened beta barrel topology, with the last strand being interrupted by a 3-10 helical turn. The N-terminal and upper 50-kDa subdomains together form the nucleotide-binding pocket. The binding of specific nucleotides alters the structural state of the myosin head during the contractile cycle.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 6 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Myosin S1 fragment, N-terminal domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 6 hidden Markov models representing the Myosin S1 fragment, N-terminal domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]