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Myosin S1 fragment, N-terminal domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   SH3-like barrel [ 50036] (21)
Superfamily:   Myosin S1 fragment, N-terminal domain [ 50084]
Families:   Myosin S1 fragment, N-terminal domain [ 50085]


Superfamily statistics
Genomes (305) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 537 589 0
Proteins 537 588 0


Functional annotation
General category Processes_IC
Detailed category Cell motility

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular component organization or biogenesis0.00035080.000000000005736Least InformativeDirect
Biological Process (BP)single-organism cellular process0.12730.002637Least InformativeInherited
Biological Process (BP)actin filament-based process0.000000018660InformativeDirect
Cellular Component (CC)non-membrane-bounded organelle0.000018970.000000000001586Least InformativeDirect
Cellular Component (CC)cytoplasmic part0.004650.5318Least InformativeInherited
Cellular Component (CC)supramolecular polymer0.0000000066930.000000006825InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 0.000000000005736 Least Informative Direct
Biological Process (BP) biological regulation 0.1066 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.002637 Least Informative Inherited
Biological Process (BP) regulation of developmental process 0.000003722 Moderately Informative Direct
Biological Process (BP) single-organism transport 0.000006166 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.00003586 Moderately Informative Direct
Biological Process (BP) cellular localization 0.0000534 Moderately Informative Direct
Biological Process (BP) reproduction 0.0002853 Moderately Informative Direct
Biological Process (BP) cellular developmental process 0.0005159 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.0005528 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.00134 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.01087 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.3686 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.02446 Moderately Informative Inherited
Biological Process (BP) nitrogen compound transport 0.03729 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.002821 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.112 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.0129 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.3893 Moderately Informative Inherited
Biological Process (BP) system development 0.3164 Moderately Informative Inherited
Biological Process (BP) actin filament-based process 0 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0.0000004867 Informative Direct
Biological Process (BP) microtubule-based process 0.000000736 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.0000007763 Informative Direct
Biological Process (BP) regulation of cell differentiation 0.000001529 Informative Direct
Biological Process (BP) supramolecular fiber organization 0.000002341 Informative Direct
Biological Process (BP) regulation of cellular localization 0.000004307 Informative Direct
Biological Process (BP) organelle localization 0.000005357 Informative Direct
Biological Process (BP) single-organism intracellular transport 0.000007677 Informative Direct
Biological Process (BP) mitotic cell cycle 0.000009946 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.00001254 Informative Direct
Biological Process (BP) generation of neurons 0.0001292 Informative Direct
Biological Process (BP) system process 0.0002862 Informative Direct
Biological Process (BP) positive regulation of developmental process 0.01121 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.005758 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.04263 Informative Inherited
Biological Process (BP) multi-organism reproductive process 0.03117 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.001873 Informative Inherited
Biological Process (BP) cell development 0.005376 Informative Inherited
Biological Process (BP) sensory organ development 0.00368 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.05529 Informative Inherited
Biological Process (BP) tissue development 0.5213 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.02107 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.0503 Informative Inherited
Biological Process (BP) single organism reproductive process 0.01822 Informative Inherited
Biological Process (BP) cell cycle process 0.002807 Informative Inherited
Biological Process (BP) embryo development 0.01994 Informative Inherited
Biological Process (BP) spermatogenesis 0.0000003545 Highly Informative Direct
Biological Process (BP) female gamete generation 0.0000007225 Highly Informative Direct
Biological Process (BP) regulation of reproductive process 0.000001703 Highly Informative Direct
Biological Process (BP) positive regulation of cellular component biogenesis 0.000002888 Highly Informative Direct
Biological Process (BP) cellular component assembly involved in morphogenesis 0.000004714 Highly Informative Direct
Biological Process (BP) cell division 0.00007778 Highly Informative Direct
Biological Process (BP) microtubule-based movement 0.0003641 Highly Informative Direct
Biological Process (BP) positive regulation of cell development 0.004653 Highly Informative Inherited
Biological Process (BP) muscle structure development 0.004791 Highly Informative Inherited
Biological Process (BP) neuron development 0.2408 Highly Informative Inherited
Biological Process (BP) germ cell development 0.01875 Highly Informative Inherited
Biological Process (BP) sensory organ morphogenesis 0.003763 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.01038 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0.0000009696 Least Informative Direct
Molecular Function (MF) binding 0.001264 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.000000000004061 Moderately Informative Direct
Molecular Function (MF) anion binding 0.0000023 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.000006663 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0.00003716 Moderately Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0.00000000002122 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.000000001718 Informative Direct
Molecular Function (MF) purine nucleotide binding 0.000000005107 Informative Direct
Molecular Function (MF) ribonucleotide binding 0.000000006148 Informative Direct
Molecular Function (MF) ATPase activity 0.1268 Informative Inherited
Molecular Function (MF) ATP binding 0.000000000104 Highly Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0.000000000001586 Least Informative Direct
Cellular Component (CC) macromolecular complex 0.000000005934 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.000002685 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.5318 Least Informative Inherited
Cellular Component (CC) cell projection 0.0000007617 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.000001699 Moderately Informative Direct
Cellular Component (CC) supramolecular polymer 0.000000006825 Informative Direct
Cellular Component (CC) actin cytoskeleton 0 Informative Direct
Cellular Component (CC) cytoplasmic region 0.000001265 Informative Direct
Cellular Component (CC) neuronal cell body 0.000000007981 Highly Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.0001635Least InformativeDirect
Biological processCell cycle0.0000007288Moderately InformativeDirect
Biological processProtein transport0.00002804Moderately InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Post-translational modificationCalmodulin-binding0InformativeDirect
Post-translational modificationActin-binding0InformativeDirect
Post-translational modificationMyosin0Highly InformativeDirect
Post-translational modificationPhosphoprotein0.0000001015Least InformativeDirect
Post-translational modificationMethylation0.00000003398Moderately InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR008989 SSF50084 Protein matches
Abstract

Myosin is a molecular motor that undergoes ATP-driven conformational changes during force production and motility. The S1 fragment myosin head consists of both the globular motor domain, containing the ATP- and actin-binding sites, and the lever arm, which amplifies small conformational changes in the motor domain into larger motions by which myosin moves actin. The motor domain contains four major subdomains linked by three single-stranded joints: the N-terminal subdomain, the upper 50-kDa subdomain, the lower 50-kDa subdomain, and the C-terminal converter subdomain [PubMed11016966]. The N-terminal subdomain has an SH3-like partly opened beta barrel topology, with the last strand being interrupted by a 3-10 helical turn. The N-terminal and upper 50-kDa subdomains together form the nucleotide-binding pocket. The binding of specific nucleotides alters the structural state of the myosin head during the contractile cycle.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 6 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Myosin S1 fragment, N-terminal domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 6 hidden Markov models representing the Myosin S1 fragment, N-terminal domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]