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Myosin S1 fragment, N-terminal domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   SH3-like barrel [ 50036] (21)
Superfamily:   Myosin S1 fragment, N-terminal domain [ 50084]
Families:   Myosin S1 fragment, N-terminal domain [ 50085]


Superfamily statistics
Genomes (305) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 537 1,426 0
Proteins 537 1,423 0


Functional annotation
General category Processes_IC
Detailed category Cell motility

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process0.00052870.00006237Least InformativeDirect
Biological Process (BP)cellular component organization or biogenesis0.00034530.000000000005849Least InformativeDirect
Biological Process (BP)single-organism cellular process0.12560.00251Least InformativeInherited
Cellular Component (CC)non-membrane-bounded organelle0.000019050.000000000001367Least InformativeDirect
Cellular Component (CC)cytoplasmic part0.004490.5152Least InformativeInherited
Cellular Component (CC)supramolecular polymer0.0000000086670.000000007473InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0.00006237 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.000000000005849 Least Informative Direct
Biological Process (BP) biological regulation 0.1091 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.00251 Least Informative Inherited
Biological Process (BP) reproduction 0.000269 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.0006353 Moderately Informative Direct
Biological Process (BP) single-organism transport 0.000005072 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.000004175 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.00003634 Moderately Informative Direct
Biological Process (BP) cellular localization 0.0001396 Moderately Informative Direct
Biological Process (BP) organelle organization 0.002493 Moderately Informative Inherited
Biological Process (BP) tissue development 0.5289 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.023 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.3585 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.011 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.001473 Moderately Informative Inherited
Biological Process (BP) nitrogen compound transport 0.03146 Moderately Informative Inherited
Biological Process (BP) animal organ development 0.06873 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.09921 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.004714 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.3899 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) mitotic cell cycle 0.00000878 Informative Direct
Biological Process (BP) system process 0.000274 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0.0000006922 Informative Direct
Biological Process (BP) microtubule-based process 0.0000007609 Informative Direct
Biological Process (BP) protein transport 0.000009965 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.0000007348 Informative Direct
Biological Process (BP) regulation of cell differentiation 0.000001892 Informative Direct
Biological Process (BP) intracellular transport 0.00003468 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.0000139 Informative Direct
Biological Process (BP) generation of neurons 0.0001463 Informative Direct
Biological Process (BP) organelle localization 0.00002354 Informative Direct
Biological Process (BP) regulation of cellular localization 0.000004041 Informative Direct
Biological Process (BP) supramolecular fiber organization 0.000002678 Informative Direct
Biological Process (BP) single-organism cellular localization 0.00005641 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0.005671 Informative Inherited
Biological Process (BP) cell cycle process 0.00258 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.001867 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.01096 Informative Inherited
Biological Process (BP) cell development 0.005841 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.02371 Informative Inherited
Biological Process (BP) embryo development 0.01955 Informative Inherited
Biological Process (BP) single organism reproductive process 0.01698 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.04741 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.03723 Informative Inherited
Biological Process (BP) multi-organism reproductive process 0.0324 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.05816 Informative Inherited
Biological Process (BP) cytokinesis 0.000000008629 Highly Informative Direct
Biological Process (BP) microtubule-based movement 0.0003338 Highly Informative Direct
Biological Process (BP) spermatogenesis 0.000000336 Highly Informative Direct
Biological Process (BP) female gamete generation 0.0000007159 Highly Informative Direct
Biological Process (BP) cellular component assembly involved in morphogenesis 0.000006509 Highly Informative Direct
Biological Process (BP) positive regulation of cellular component biogenesis 0.000002809 Highly Informative Direct
Biological Process (BP) establishment of organelle localization 0.000000000003322 Highly Informative Direct
Biological Process (BP) striated muscle cell development 0.00000003044 Highly Informative Direct
Biological Process (BP) muscle tissue development 0.00001865 Highly Informative Direct
Biological Process (BP) regulation of reproductive process 0.000001484 Highly Informative Direct
Biological Process (BP) positive regulation of cell development 0.00475 Highly Informative Inherited
Biological Process (BP) neuron development 0.2413 Highly Informative Inherited
Biological Process (BP) sensory organ morphogenesis 0.003581 Highly Informative Inherited
Biological Process (BP) germ cell development 0.01804 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0.000000759 Least Informative Direct
Molecular Function (MF) binding 0.001409 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.000000000003038 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0.00002814 Moderately Informative Direct
Molecular Function (MF) anion binding 0.00000194 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.000003317 Moderately Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0.00000000001784 Informative Direct
Molecular Function (MF) purine nucleotide binding 0.000000003864 Informative Direct
Molecular Function (MF) ribonucleotide binding 0.000000004665 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.000000001274 Informative Direct
Molecular Function (MF) ATPase activity 0.1286 Informative Inherited
Molecular Function (MF) ATP binding 0.00000000007768 Highly Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0.000000000001367 Least Informative Direct
Cellular Component (CC) protein complex 0.000000000001991 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.000002556 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.5152 Least Informative Inherited
Cellular Component (CC) cytoskeleton 0.000002155 Moderately Informative Direct
Cellular Component (CC) cell projection 0.0000009096 Moderately Informative Direct
Cellular Component (CC) actin cytoskeleton 0 Informative Direct
Cellular Component (CC) supramolecular polymer 0.000000007473 Informative Direct
Cellular Component (CC) cytoplasmic region 0.000001428 Informative Direct
Cellular Component (CC) neuronal cell body 0.00000001038 Highly Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.0001652Least InformativeDirect
Biological processCell cycle0.0000007354Moderately InformativeDirect
Biological processProtein transport0.0000277Moderately InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Post-translational modificationActin-binding0InformativeDirect
Post-translational modificationCalmodulin-binding0InformativeDirect
Post-translational modificationMyosin0Highly InformativeDirect
Post-translational modificationPhosphoprotein0.0000001011Least InformativeDirect
Post-translational modificationMethylation0.00000003261Moderately InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR008989 SSF50084 Protein matches
Abstract

Myosin is a molecular motor that undergoes ATP-driven conformational changes during force production and motility. The S1 fragment myosin head consists of both the globular motor domain, containing the ATP- and actin-binding sites, and the lever arm, which amplifies small conformational changes in the motor domain into larger motions by which myosin moves actin. The motor domain contains four major subdomains linked by three single-stranded joints: the N-terminal subdomain, the upper 50-kDa subdomain, the lower 50-kDa subdomain, and the C-terminal converter subdomain [PubMed11016966]. The N-terminal subdomain has an SH3-like partly opened beta barrel topology, with the last strand being interrupted by a 3-10 helical turn. The N-terminal and upper 50-kDa subdomains together form the nucleotide-binding pocket. The binding of specific nucleotides alters the structural state of the myosin head during the contractile cycle.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 6 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Myosin S1 fragment, N-terminal domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 6 hidden Markov models representing the Myosin S1 fragment, N-terminal domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]