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GroES-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   GroES-like [ 50128] (2)
Superfamily:   GroES-like [ 50129] (2)
Families:   GroES [ 50130] (2)
  Alcohol dehydrogenase-like, N-terminal domain [ 50136] (15)


Superfamily statistics
Genomes (3,184) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 48,694 253,184 93
Proteins 44,490 234,712 68


Functional annotation
General category Processes_IC
Detailed category Protein modification

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)protein folding00.0008242Highly InformativeDirect
Molecular Function (MF)binding0.0017081Least InformativeInherited
Molecular Function (MF)chaperone binding0.00000000036690.0000159Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.00000000008874 Moderately Informative Direct
Biological Process (BP) lipid metabolic process 0.0001137 Moderately Informative Direct
Biological Process (BP) monocarboxylic acid metabolic process 0.000023 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.0005802 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 0.0669 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.002047 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.8337 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.8524 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.9972 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.1163 Moderately Informative Inherited
Biological Process (BP) nucleoside phosphate metabolic process 0.535 Moderately Informative Inherited
Biological Process (BP) cofactor metabolic process 0.03655 Moderately Informative Inherited
Biological Process (BP) generation of precursor metabolites and energy 0.02007 Moderately Informative Inherited
Biological Process (BP) oxidation-reduction process 0.07924 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 0.8787 Moderately Informative Inherited
Biological Process (BP) monosaccharide metabolic process 0.0000309 Informative Direct
Biological Process (BP) alcohol metabolic process 0 Informative Direct
Biological Process (BP) cellular aldehyde metabolic process 0.0000000002415 Informative Direct
Biological Process (BP) fatty acid metabolic process 0.00001492 Informative Direct
Biological Process (BP) carbohydrate catabolic process 0.00005368 Informative Direct
Biological Process (BP) secondary metabolic process 0 Informative Direct
Biological Process (BP) cellular carbohydrate metabolic process 0.0000001741 Informative Direct
Biological Process (BP) localization of cell 1 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.8311 Informative Inherited
Biological Process (BP) movement of cell or subcellular component 1 Informative Inherited
Biological Process (BP) locomotion 1 Informative Inherited
Biological Process (BP) aspartate family amino acid metabolic process 0.002381 Informative Inherited
Biological Process (BP) oxidoreduction coenzyme metabolic process 0.03653 Informative Inherited
Biological Process (BP) pyridine-containing compound metabolic process 0.002762 Informative Inherited
Biological Process (BP) isoprenoid metabolic process 0.2846 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 0.2747 Informative Inherited
Biological Process (BP) organic hydroxy compound biosynthetic process 0.001773 Informative Inherited
Biological Process (BP) fermentation 0.0000005092 Highly Informative Direct
Biological Process (BP) protein folding 0.0008242 Highly Informative Direct
Biological Process (BP) xenobiotic metabolic process 0.000009854 Highly Informative Direct
Biological Process (BP) phenylpropanoid metabolic process 0.0000000000005225 Highly Informative Direct
Biological Process (BP) polyketide metabolic process 0.00000005022 Highly Informative Direct
Biological Process (BP) primary alcohol metabolic process 0.00000001074 Highly Informative Direct
Biological Process (BP) cell wall biogenesis 0.0002696 Highly Informative Direct
Biological Process (BP) cellular carbohydrate catabolic process 0.00000005302 Highly Informative Direct
Biological Process (BP) secondary metabolite biosynthetic process 0.00001012 Highly Informative Direct
Biological Process (BP) alcohol catabolic process 0.00003978 Highly Informative Direct
Biological Process (BP) aldehyde catabolic process 0.0000003769 Highly Informative Direct
Biological Process (BP) detoxification 0.00001012 Highly Informative Direct
Biological Process (BP) glucose metabolic process 0.9057 Highly Informative Inherited
Biological Process (BP) response to carbohydrate 0.01094 Highly Informative Inherited
Biological Process (BP) monosaccharide catabolic process 0.0134 Highly Informative Inherited
Biological Process (BP) polyol metabolic process 1 Highly Informative Inherited
Biological Process (BP) NAD metabolic process 0.06187 Highly Informative Inherited
Biological Process (BP) diterpenoid metabolic process 0.02072 Highly Informative Inherited
Biological Process (BP) alcohol biosynthetic process 0.007921 Highly Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0.000001842 Moderately Informative Direct
Molecular Function (MF) anion binding 0.771 Moderately Informative Inherited
Molecular Function (MF) metal ion binding 0.001546 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 1 Moderately Informative Inherited
Molecular Function (MF) zinc ion binding 0.00007852 Informative Direct
Molecular Function (MF) coenzyme binding 0.00001249 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 0.001421 Informative Inherited
Molecular Function (MF) RNA binding 1 Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 0 Highly Informative Direct
Molecular Function (MF) NADP binding 0 Highly Informative Direct
Molecular Function (MF) chaperone binding 0.0000159 Highly Informative Direct
Molecular Function (MF) NAD binding 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-CH group of donors 0.0163 Highly Informative Inherited
Molecular Function (MF) monosaccharide binding 0.01528 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on the aldehyde or oxo group of donors 1 Highly Informative Inherited
Cellular Component (CC) cell projection 1 Moderately Informative Inherited
Cellular Component (CC) cilium 0.1811 Informative Inherited
Cellular Component (CC) motile cilium 0.000008034 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds1Least InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)Hydro-lyases1Moderately InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0.5949Moderately InformativeInherited
Enzyme Commission (EC)Acting on NADH or NADPH1Moderately InformativeInherited
Enzyme Commission (EC)Acting on the CH-CH group of donors0.07986Moderately InformativeInherited
Enzyme Commission (EC)Fatty-acid synthase0.0000000000003114InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-acetyltransferase0.000000000001168InformativeDirect
Enzyme Commission (EC)3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat0.000000000001168InformativeDirect
Enzyme Commission (EC)Enoyl-[acyl-carrier-protein] reductase (NADPH, B-s0.000000002503InformativeDirect
Enzyme Commission (EC)Thiolester hydrolases0.001002InformativeInherited
Enzyme Commission (EC)[Acyl-carrier-protein] S-malonyltransferase0.000000001549Highly InformativeDirect
Enzyme Commission (EC)Beta-ketoacyl-acyl-carrier-protein synthase I0.000000003924Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCarbohydrate metabolism0.00006615Moderately InformativeDirect
Biological processLipid metabolism0.1945Moderately InformativeInherited
Biological processFatty acid metabolism0.000000002048InformativeDirect
Biological processStress response0.0001795InformativeDirect
Biological processLipid biosynthesis0.08743InformativeInherited
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentMitochondrion0.0002042Moderately InformativeDirect
Cellular componentCell projection0.4497Moderately InformativeInherited
Cellular componentCilium0.00007302InformativeDirect
Cellular componentFlagellum0.00000000003499Highly InformativeDirect
Cellular componentLipid droplet0.0000000001166Highly InformativeDirect
DomainTransit peptide0.0004309Moderately InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Molecular functionNADP0Moderately InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationChaperone0InformativeDirect
Post-translational modificationAcetylation0.00000000000002913Least InformativeDirect
Post-translational modificationPhosphopantetheine0Highly InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR011032 SSF50129 Protein matches
Abstract

GroES (chaperonin 10) is an oligomeric molecular chaperone, which functions in protein folding and possibly in intercellular signalling, being found on the surface of various prokaryotic and eukaryotic cells, as well as being released from cells. Secreted chaperonins are thought to act as intercellular signals, interacting with a variety of cell types, including leukocytes, vascular endothelial cells and epithelial cells, as well as activating key cellular activities such as the synthesis of cytokines and adhesion proteins [PubMed14585136]. GroES works as a co-chaperone with GroEL (chaperonin 60) during protein folding. The polypeptide substrate is captured by GroEL, which bind the co-chaperone GroES and ATP, and discharges the substrate into a unique microenvironment inside of the chaperone, which promotes productive folding. After hydrolysis of ATP, the polypeptide is released into solution [PubMed12475168]. GP31 from Bacteriophage T4 is functionally equivalent to GroES. GroES folds as a partly opened beta-barrel.

The N-terminal domain of alcohol dehydrogenase-like proteins have a GroES-like fold, the C-terminal domain having a classical Rossman-fold [PubMed11274460]. These proteins include, alcohol dehydrogenase, which contains a zinc-finger subdomain within the GroES-like domain, ketose reductase (sorbitol dehydrogenase), formaldehyde dehydrogenase, quinone oxidoreductase and 2,4-dienoyl-CoA reductase.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 36 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a GroES-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 36 hidden Markov models representing the GroES-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]