SUPERFAMILY 1.75 HMM library and genome assignments server


GroES-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   GroES-like [ 50128] (2)
Superfamily:   GroES-like [ 50129] (2)
Families:   GroES [ 50130] (2)
  Alcohol dehydrogenase-like, N-terminal domain [ 50136] (15)


Superfamily statistics
Genomes (3,177) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 48,525 209,441 93
Proteins 44,324 195,170 68


Functional annotation
General category Processes_IC
Detailed category Protein modification

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Molecular Function (MF)binding0.0027491Least InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) carbohydrate metabolic process 6.369e-08 Moderately Informative Direct
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.8546 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.009149 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.9778 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) single-organism biosynthetic process 0.02522 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.001956 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.00272 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.1047 Moderately Informative Inherited
Biological Process (BP) alcohol metabolic process 0 Informative Direct
Biological Process (BP) secondary metabolic process 0 Informative Direct
Biological Process (BP) cellular aldehyde metabolic process 6.647e-09 Informative Direct
Biological Process (BP) carbohydrate catabolic process 1.693e-08 Informative Direct
Biological Process (BP) cellular carbohydrate metabolic process 8.676e-07 Informative Direct
Biological Process (BP) fatty acid metabolic process 3.185e-05 Informative Direct
Biological Process (BP) cell wall organization or biogenesis 0.1609 Informative Inherited
Biological Process (BP) organic hydroxy compound biosynthetic process 0.004811 Informative Inherited
Biological Process (BP) isoprenoid metabolic process 0.03168 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.09033 Informative Inherited
Biological Process (BP) cellular component movement 1 Informative Inherited
Biological Process (BP) locomotion 1 Informative Inherited
Biological Process (BP) localization of cell 1 Informative Inherited
Biological Process (BP) energy derivation by oxidation of organic compounds 0.6695 Informative Inherited
Biological Process (BP) hexose metabolic process 1 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 0.08454 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 0.8965 Informative Inherited
Biological Process (BP) primary alcohol metabolic process 0 Highly Informative Direct
Biological Process (BP) phenylpropanoid metabolic process 5.249e-12 Highly Informative Direct
Biological Process (BP) xenobiotic metabolic process 3.358e-10 Highly Informative Direct
Biological Process (BP) alcohol catabolic process 2.19e-08 Highly Informative Direct
Biological Process (BP) retinoid metabolic process 3.762e-07 Highly Informative Direct
Biological Process (BP) aldehyde catabolic process 2.604e-05 Highly Informative Direct
Biological Process (BP) cellular carbohydrate catabolic process 8.715e-05 Highly Informative Direct
Biological Process (BP) cellular hormone metabolic process 0.003871 Highly Informative Inherited
Biological Process (BP) galactose metabolic process 0.008192 Highly Informative Inherited
Biological Process (BP) secondary metabolite biosynthetic process 0.1208 Highly Informative Inherited
Biological Process (BP) polyol metabolic process 0.5697 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.9442 Moderately Informative Inherited
Molecular Function (MF) cation binding 0.1776 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 1 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on CH-OH group of donors 0 Informative Direct
Molecular Function (MF) cofactor binding 1.562e-15 Informative Direct
Molecular Function (MF) zinc ion binding 0.0002918 Informative Direct
Molecular Function (MF) nucleotide binding 0.06697 Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on NAD(P)H 0.003282 Informative Inherited
Molecular Function (MF) RNA binding 1 Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 0 Highly Informative Direct
Molecular Function (MF) NADP binding 0 Highly Informative Direct
Molecular Function (MF) NAD binding 8.006e-16 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 8.731e-09 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the aldehyde or oxo group of donors 1 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on the CH-CH group of donors 0.003739 Highly Informative Inherited
Molecular Function (MF) monosaccharide binding 0.006119 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds1Least InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)Hydro-lyases1Moderately InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0.5949Moderately InformativeInherited
Enzyme Commission (EC)Acting on NADH or NADPH1Moderately InformativeInherited
Enzyme Commission (EC)Acting on the CH-CH group of donors0.07986Moderately InformativeInherited
Enzyme Commission (EC)Fatty-acid synthase3.114e-13InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-acetyltransferase1.168e-12InformativeDirect
Enzyme Commission (EC)3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat1.168e-12InformativeDirect
Enzyme Commission (EC)Enoyl-[acyl-carrier-protein] reductase (NADPH, B-s2.503e-09InformativeDirect
Enzyme Commission (EC)Thiolester hydrolases0.001002InformativeInherited
Enzyme Commission (EC)[Acyl-carrier-protein] S-malonyltransferase1.549e-09Highly InformativeDirect
Enzyme Commission (EC)Beta-ketoacyl-acyl-carrier-protein synthase I3.924e-09Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)disease of mental health0.09996Moderately InformativeInherited
Disease Ontology (DO)substance dependence0.0002747InformativeDirect

Document: DO annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0.2122Least InformativeInherited
Plant ANatomical entity (PAN)vascular system0.00079InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Acting on the CH-OH group of donors0Moderately InformativeDirect
Enzyme Commission (EC)Acyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor4.754e-15InformativeDirect
Enzyme Commission (EC)Acting on NADH or NADPH1InformativeInherited
Enzyme Commission (EC)Beta-ketoacyl-[acyl-carrier-protein] synthase I2.893e-14Highly InformativeDirect
Enzyme Commission (EC)Fatty-acid synthase3.712e-13Highly InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-acetyltransferase1.39e-12Highly InformativeDirect
Enzyme Commission (EC)Oleoyl-[acyl-carrier-protein] hydrolase3.179e-11Highly InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-malonyltransferase1.843e-09Highly InformativeDirect
Enzyme Commission (EC)Enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific)6.007e-06Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCarbohydrate metabolism6.18e-05Moderately InformativeDirect
Biological processLipid metabolism0.1844Moderately InformativeInherited
Biological processFatty acid metabolism6.211e-09InformativeDirect
Biological processStress response0.0001576InformativeDirect
Biological processLipid biosynthesis0.04626InformativeInherited
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentCell projection0.1827Moderately InformativeInherited
Cellular componentLipid droplet4.741e-12Highly InformativeDirect
Cellular componentCilium9.655e-05Highly InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Molecular functionNADP0InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationChaperone0InformativeDirect
Post-translational modificationAcetylation0Least InformativeDirect
Post-translational modificationPhosphopantetheine0Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)amino-acid metabolism0Least InformativeDirect
UniPathway (UP)aromatic compound metabolism0.5395Least InformativeInherited
UniPathway (UP)carbohydrate metabolism1Least InformativeInherited
UniPathway (UP)amino-acid degradation0Moderately InformativeDirect
UniPathway (UP)aromatic compound biosynthesis0Moderately InformativeDirect
UniPathway (UP)carbohydrate degradation0.1679Moderately InformativeInherited
UniPathway (UP)metabolic intermediate biosynthesis1Moderately InformativeInherited
UniPathway (UP)phenylpropanoid biosynthesis0InformativeDirect
UniPathway (UP)antibiotic biosynthesis7.328e-08InformativeDirect
UniPathway (UP)L-threonine degradation0Highly InformativeDirect
UniPathway (UP)2-deoxystreptamine biosynthesis4.664e-15Highly InformativeDirect
UniPathway (UP)aminoglycoside antibiotic biosynthesis5.115e-07Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR011032 SSF50129 Protein matches
Abstract

GroES (chaperonin 10) is an oligomeric molecular chaperone, which functions in protein folding and possibly in intercellular signalling, being found on the surface of various prokaryotic and eukaryotic cells, as well as being released from cells. Secreted chaperonins are thought to act as intercellular signals, interacting with a variety of cell types, including leukocytes, vascular endothelial cells and epithelial cells, as well as activating key cellular activities such as the synthesis of cytokines and adhesion proteins [PubMed14585136]. GroES works as a co-chaperone with GroEL (chaperonin 60) during protein folding. The polypeptide substrate is captured by GroEL, which bind the co-chaperone GroES and ATP, and discharges the substrate into a unique microenvironment inside of the chaperone, which promotes productive folding. After hydrolysis of ATP, the polypeptide is released into solution [PubMed12475168]. GP31 from Bacteriophage T4 is functionally equivalent to GroES. GroES folds as a partly opened beta-barrel.

The N-terminal domain of alcohol dehydrogenase-like proteins have a GroES-like fold, the C-terminal domain having a classical Rossman-fold [PubMed11274460]. These proteins include, alcohol dehydrogenase, which contains a zinc-finger subdomain within the GroES-like domain, ketose reductase (sorbitol dehydrogenase), formaldehyde dehydrogenase, quinone oxidoreductase and 2,4-dienoyl-CoA reductase.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 36 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a GroES-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 36 hidden Markov models representing the GroES-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]