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GroES-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   GroES-like [ 50128] (2)
Superfamily:   GroES-like [ 50129] (2)
Families:   GroES [ 50130] (2)
  Alcohol dehydrogenase-like, N-terminal domain [ 50136] (15)


Superfamily statistics
Genomes (3,183) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 48,685 209,441 93
Proteins 44,482 195,170 68


Functional annotation
General category Processes_IC
Detailed category Protein modification

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)protein folding00.0009487Highly InformativeDirect
Molecular Function (MF)binding0.0013231Least InformativeInherited
Molecular Function (MF)chaperone binding0.00000000053870.00001659Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.0000000003153 Moderately Informative Direct
Biological Process (BP) monocarboxylic acid metabolic process 0.00003561 Moderately Informative Direct
Biological Process (BP) lipid metabolic process 0.0001556 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 0.1131 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.8325 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.8493 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) oxidation-reduction process 0.09118 Moderately Informative Inherited
Biological Process (BP) generation of precursor metabolites and energy 0.01985 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.001876 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.005679 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.178 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 0.9562 Moderately Informative Inherited
Biological Process (BP) alcohol metabolic process 0 Informative Direct
Biological Process (BP) secondary metabolic process 0 Informative Direct
Biological Process (BP) cellular aldehyde metabolic process 0.0000000002536 Informative Direct
Biological Process (BP) cellular carbohydrate metabolic process 0.0000005939 Informative Direct
Biological Process (BP) fatty acid metabolic process 0.00001931 Informative Direct
Biological Process (BP) monosaccharide metabolic process 0.00006054 Informative Direct
Biological Process (BP) fatty acid derivative metabolic process 0.00008352 Informative Direct
Biological Process (BP) carbohydrate catabolic process 0.0001046 Informative Direct
Biological Process (BP) movement of cell or subcellular component 1 Informative Inherited
Biological Process (BP) cell wall organization or biogenesis 0.01253 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.9155 Informative Inherited
Biological Process (BP) locomotion 1 Informative Inherited
Biological Process (BP) aspartate family amino acid metabolic process 0.002421 Informative Inherited
Biological Process (BP) isoprenoid metabolic process 0.2572 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 0.3072 Informative Inherited
Biological Process (BP) organic hydroxy compound biosynthetic process 0.003894 Informative Inherited
Biological Process (BP) protein folding 0.0009487 Highly Informative Direct
Biological Process (BP) phenylpropanoid metabolic process 0.0000000000005667 Highly Informative Direct
Biological Process (BP) primary alcohol metabolic process 0.00000000652 Highly Informative Direct
Biological Process (BP) polyketide metabolic process 0.00000004432 Highly Informative Direct
Biological Process (BP) cellular carbohydrate catabolic process 0.0000002372 Highly Informative Direct
Biological Process (BP) aldehyde catabolic process 0.0000003186 Highly Informative Direct
Biological Process (BP) fermentation 0.0000005409 Highly Informative Direct
Biological Process (BP) secondary metabolite biosynthetic process 0.00000843 Highly Informative Direct
Biological Process (BP) xenobiotic metabolic process 0.000009777 Highly Informative Direct
Biological Process (BP) detoxification 0.00001005 Highly Informative Direct
Biological Process (BP) alcohol catabolic process 0.00009037 Highly Informative Direct
Biological Process (BP) cell wall biogenesis 0.000236 Highly Informative Direct
Biological Process (BP) glucose metabolic process 0.8078 Highly Informative Inherited
Biological Process (BP) response to carbohydrate 0.008998 Highly Informative Inherited
Biological Process (BP) monosaccharide catabolic process 0.009815 Highly Informative Inherited
Biological Process (BP) polyol metabolic process 1 Highly Informative Inherited
Biological Process (BP) diterpenoid metabolic process 0.02049 Highly Informative Inherited
Biological Process (BP) alcohol biosynthetic process 0.01403 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0.0000043 Moderately Informative Direct
Molecular Function (MF) anion binding 0.7968 Moderately Informative Inherited
Molecular Function (MF) metal ion binding 0.001152 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 1 Moderately Informative Inherited
Molecular Function (MF) coenzyme binding 0.00001519 Informative Direct
Molecular Function (MF) zinc ion binding 0.00006614 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 0.002976 Informative Inherited
Molecular Function (MF) RNA binding 1 Informative Inherited
Molecular Function (MF) chaperone binding 0.00001659 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 0 Highly Informative Direct
Molecular Function (MF) NADP binding 0 Highly Informative Direct
Molecular Function (MF) NAD binding 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-CH group of donors 0.01648 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on the aldehyde or oxo group of donors 1 Highly Informative Inherited
Molecular Function (MF) monosaccharide binding 0.01328 Highly Informative Inherited
Cellular Component (CC) cell projection 1 Moderately Informative Inherited
Cellular Component (CC) cilium 0.1636 Informative Inherited
Cellular Component (CC) motile cilium 0.000008454 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds1Least InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)Hydro-lyases1Moderately InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0.5949Moderately InformativeInherited
Enzyme Commission (EC)Acting on NADH or NADPH1Moderately InformativeInherited
Enzyme Commission (EC)Acting on the CH-CH group of donors0.07986Moderately InformativeInherited
Enzyme Commission (EC)Fatty-acid synthase0.0000000000003114InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-acetyltransferase0.000000000001168InformativeDirect
Enzyme Commission (EC)3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat0.000000000001168InformativeDirect
Enzyme Commission (EC)Enoyl-[acyl-carrier-protein] reductase (NADPH, B-s0.000000002503InformativeDirect
Enzyme Commission (EC)Thiolester hydrolases0.001002InformativeInherited
Enzyme Commission (EC)[Acyl-carrier-protein] S-malonyltransferase0.000000001549Highly InformativeDirect
Enzyme Commission (EC)Beta-ketoacyl-acyl-carrier-protein synthase I0.000000003924Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)disease of mental health0.087Moderately InformativeInherited
Disease Ontology (DO)substance dependence0.0004506InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging0.2789Least InformativeInherited
Mammalian Phenotype (MP)abnormal induced morbidity/mortality0.004411Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal sensitivity to induced morbidity/mortality0.002104InformativeInherited
Mammalian Phenotype (MP)increased sensitivity to induced morbidity/mortality0.0009032Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)life span variant0.0007925InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0.2128Least InformativeInherited
Plant ANatomical entity (PAN)portion of vascular tissue0.00001707InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Acting on the CH-OH group of donors0Moderately InformativeDirect
Enzyme Commission (EC)Acyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.000000000000001227InformativeDirect
Enzyme Commission (EC)Thiolester hydrolases0.001482InformativeInherited
Enzyme Commission (EC)Acting on NADH or NADPH1InformativeInherited
Enzyme Commission (EC)Beta-ketoacyl-[acyl-carrier-protein] synthase I0.00000000000004171Highly InformativeDirect
Enzyme Commission (EC)Fatty-acid synthase0.0000000000003641Highly InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-acetyltransferase0.000000000002398Highly InformativeDirect
Enzyme Commission (EC)Oleoyl-[acyl-carrier-protein] hydrolase0.00000000005996Highly InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-malonyltransferase0.000000002132Highly InformativeDirect
Enzyme Commission (EC)Enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific)0.000006897Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCarbohydrate metabolism0.0001019Moderately InformativeDirect
Biological processLipid metabolism0.1762Moderately InformativeInherited
Biological processFatty acid metabolism0.000000001612InformativeDirect
Biological processStress response0.0001433InformativeDirect
Biological processLipid biosynthesis0.0903InformativeInherited
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentMitochondrion0.0005402Moderately InformativeDirect
Cellular componentCell projection0.5979Moderately InformativeInherited
Cellular componentCilium0.0003308InformativeDirect
Cellular componentLipid droplet0.0000000001156Highly InformativeDirect
Cellular componentFlagellum0.0000000007543Highly InformativeDirect
DomainTransit peptide0.0006535Moderately InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Molecular functionNADP0Moderately InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationChaperone0InformativeDirect
Post-translational modificationAcetylation0.0000000000000419Least InformativeDirect
Post-translational modificationPhosphopantetheine0Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)amino-acid metabolism0Least InformativeDirect
UniPathway (UP)aromatic compound metabolism0.5224Least InformativeInherited
UniPathway (UP)biopolymer metabolism1Least InformativeInherited
UniPathway (UP)carbohydrate metabolism1Least InformativeInherited
UniPathway (UP)amino-acid degradation0Moderately InformativeDirect
UniPathway (UP)aromatic compound biosynthesis0Moderately InformativeDirect
UniPathway (UP)antibiotic biosynthesis0.00000001094Moderately InformativeDirect
UniPathway (UP)secondary metabolite metabolism0.001245Moderately InformativeInherited
UniPathway (UP)organic acid metabolism0.002726Moderately InformativeInherited
UniPathway (UP)alcohol metabolism0.07223Moderately InformativeInherited
UniPathway (UP)carbohydrate degradation0.2215Moderately InformativeInherited
UniPathway (UP)biopolymer biosynthesis1Moderately InformativeInherited
UniPathway (UP)metabolic intermediate biosynthesis1Moderately InformativeInherited
UniPathway (UP)cell wall metabolism1Moderately InformativeInherited
UniPathway (UP)cellular component biogenesis1Moderately InformativeInherited
UniPathway (UP)phenylpropanoid biosynthesis0InformativeDirect
UniPathway (UP)organic acid biosynthesis0.005275InformativeInherited
UniPathway (UP)polyketide biosynthesis0.01445InformativeInherited
UniPathway (UP)L-threonine degradation0Highly InformativeDirect
UniPathway (UP)2-deoxystreptamine biosynthesis0.00000000000000652Highly InformativeDirect
UniPathway (UP)teichoic acid biosynthesis0.000000142Highly InformativeDirect
UniPathway (UP)aminoglycoside antibiotic biosynthesis0.000003268Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR011032 SSF50129 Protein matches
Abstract

GroES (chaperonin 10) is an oligomeric molecular chaperone, which functions in protein folding and possibly in intercellular signalling, being found on the surface of various prokaryotic and eukaryotic cells, as well as being released from cells. Secreted chaperonins are thought to act as intercellular signals, interacting with a variety of cell types, including leukocytes, vascular endothelial cells and epithelial cells, as well as activating key cellular activities such as the synthesis of cytokines and adhesion proteins [PubMed14585136]. GroES works as a co-chaperone with GroEL (chaperonin 60) during protein folding. The polypeptide substrate is captured by GroEL, which bind the co-chaperone GroES and ATP, and discharges the substrate into a unique microenvironment inside of the chaperone, which promotes productive folding. After hydrolysis of ATP, the polypeptide is released into solution [PubMed12475168]. GP31 from Bacteriophage T4 is functionally equivalent to GroES. GroES folds as a partly opened beta-barrel.

The N-terminal domain of alcohol dehydrogenase-like proteins have a GroES-like fold, the C-terminal domain having a classical Rossman-fold [PubMed11274460]. These proteins include, alcohol dehydrogenase, which contains a zinc-finger subdomain within the GroES-like domain, ketose reductase (sorbitol dehydrogenase), formaldehyde dehydrogenase, quinone oxidoreductase and 2,4-dienoyl-CoA reductase.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 36 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a GroES-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 36 hidden Markov models representing the GroES-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]