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GroES-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   GroES-like [ 50128] (2)
Superfamily:   GroES-like [ 50129] (2)
Families:   GroES [ 50130] (2)
  Alcohol dehydrogenase-like, N-terminal domain [ 50136] (15)


Superfamily statistics
Genomes (3,179) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 48,532 209,441 93
Proteins 44,336 195,170 68


Functional annotation
General category Processes_IC
Detailed category Protein modification

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)protein folding00.0007363Highly InformativeDirect
Molecular Function (MF)binding0.0027811Least InformativeInherited
Molecular Function (MF)protein binding0.15591Moderately InformativeInherited
Molecular Function (MF)chaperone binding0.00000000016330.00001205Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.000000001443 Moderately Informative Direct
Biological Process (BP) lipid metabolic process 0.00005507 Moderately Informative Direct
Biological Process (BP) monocarboxylic acid metabolic process 0.00004377 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.004548 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.004292 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 0.1127 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.1742 Moderately Informative Inherited
Biological Process (BP) oxidation-reduction process 0.1657 Moderately Informative Inherited
Biological Process (BP) generation of precursor metabolites and energy 0.01838 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 0.8195 Moderately Informative Inherited
Biological Process (BP) monosaccharide metabolic process 0.00004899 Informative Direct
Biological Process (BP) alcohol metabolic process 0 Informative Direct
Biological Process (BP) cellular aldehyde metabolic process 0.000000002338 Informative Direct
Biological Process (BP) fatty acid metabolic process 0.00002659 Informative Direct
Biological Process (BP) carbohydrate catabolic process 0.0001366 Informative Direct
Biological Process (BP) secondary metabolic process 0 Informative Direct
Biological Process (BP) cellular carbohydrate metabolic process 0.000001947 Informative Direct
Biological Process (BP) movement of cell or subcellular component 1 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.8803 Informative Inherited
Biological Process (BP) locomotion 1 Informative Inherited
Biological Process (BP) aspartate family amino acid metabolic process 0.002342 Informative Inherited
Biological Process (BP) isoprenoid metabolic process 0.2793 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 0.3846 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 0.2664 Informative Inherited
Biological Process (BP) organic hydroxy compound biosynthetic process 0.002757 Informative Inherited
Biological Process (BP) fermentation 0.0000006514 Highly Informative Direct
Biological Process (BP) protein folding 0.0007363 Highly Informative Direct
Biological Process (BP) phenylpropanoid metabolic process 0.0000000000004697 Highly Informative Direct
Biological Process (BP) polyketide metabolic process 0.00000005247 Highly Informative Direct
Biological Process (BP) primary alcohol metabolic process 0.000000001414 Highly Informative Direct
Biological Process (BP) cell wall biogenesis 0.0002593 Highly Informative Direct
Biological Process (BP) alcohol catabolic process 0.0001659 Highly Informative Direct
Biological Process (BP) aldehyde catabolic process 0.0000001862 Highly Informative Direct
Biological Process (BP) cellular response to xenobiotic stimulus 0.0000001378 Highly Informative Direct
Biological Process (BP) response to carbohydrate 0.008589 Highly Informative Inherited
Biological Process (BP) glucose metabolic process 0.7574 Highly Informative Inherited
Biological Process (BP) monosaccharide catabolic process 0.01116 Highly Informative Inherited
Biological Process (BP) polyol metabolic process 1 Highly Informative Inherited
Biological Process (BP) diterpenoid metabolic process 0.02032 Highly Informative Inherited
Biological Process (BP) alcohol biosynthetic process 0.01521 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0.0000009275 Moderately Informative Direct
Molecular Function (MF) metal ion binding 0.0008321 Moderately Informative Direct
Molecular Function (MF) anion binding 0.7847 Moderately Informative Inherited
Molecular Function (MF) protein binding 1 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 1 Moderately Informative Inherited
Molecular Function (MF) zinc ion binding 0.0000566 Informative Direct
Molecular Function (MF) coenzyme binding 0.000009901 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 0.003427 Informative Inherited
Molecular Function (MF) RNA binding 1 Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 0 Highly Informative Direct
Molecular Function (MF) NADP binding 0 Highly Informative Direct
Molecular Function (MF) chaperone binding 0.00001205 Highly Informative Direct
Molecular Function (MF) NAD binding 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-CH group of donors 0.01748 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on the aldehyde or oxo group of donors 1 Highly Informative Inherited
Molecular Function (MF) monosaccharide binding 0.01972 Highly Informative Inherited
Molecular Function (MF) mRNA binding 0.0603 Highly Informative Inherited
Cellular Component (CC) cell projection 1 Moderately Informative Inherited
Cellular Component (CC) cilium 0.1387 Informative Inherited
Cellular Component (CC) motile cilium 0.000004841 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds1Least InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)Hydro-lyases1Moderately InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0.5949Moderately InformativeInherited
Enzyme Commission (EC)Acting on NADH or NADPH1Moderately InformativeInherited
Enzyme Commission (EC)Acting on the CH-CH group of donors0.07986Moderately InformativeInherited
Enzyme Commission (EC)Fatty-acid synthase0.0000000000003114InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-acetyltransferase0.000000000001168InformativeDirect
Enzyme Commission (EC)3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat0.000000000001168InformativeDirect
Enzyme Commission (EC)Enoyl-[acyl-carrier-protein] reductase (NADPH, B-s0.000000002503InformativeDirect
Enzyme Commission (EC)Thiolester hydrolases0.001002InformativeInherited
Enzyme Commission (EC)[Acyl-carrier-protein] S-malonyltransferase0.000000001549Highly InformativeDirect
Enzyme Commission (EC)Beta-ketoacyl-acyl-carrier-protein synthase I0.000000003924Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)disease of mental health0.08693Moderately InformativeInherited
Disease Ontology (DO)substance dependence0.0004508InformativeDirect

Document: DO annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0.2128Least InformativeInherited
Plant ANatomical entity (PAN)portion of vascular tissue0.00001707InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Acting on the CH-OH group of donors0Moderately InformativeDirect
Enzyme Commission (EC)Acyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.000000000000001219InformativeDirect
Enzyme Commission (EC)Acting on NADH or NADPH1InformativeInherited
Enzyme Commission (EC)Beta-ketoacyl-[acyl-carrier-protein] synthase I0.00000000000004468Highly InformativeDirect
Enzyme Commission (EC)Fatty-acid synthase0.0000000000003811Highly InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-acetyltransferase0.000000000002511Highly InformativeDirect
Enzyme Commission (EC)Oleoyl-[acyl-carrier-protein] hydrolase0.00000000004562Highly InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-malonyltransferase0.000000002232Highly InformativeDirect
Enzyme Commission (EC)Enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific)0.000006847Highly InformativeDirect

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)all other therapeutic products1Moderately InformativeInherited
Drugbank ATC_code (DB)fomepizole0.000000008187Highly InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCarbohydrate metabolism0.00009503Moderately InformativeDirect
Biological processLipid metabolism0.1737Moderately InformativeInherited
Biological processFatty acid metabolism0.000000001616InformativeDirect
Biological processStress response0.0001173InformativeDirect
Biological processLipid biosynthesis0.09194InformativeInherited
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentMitochondrion0.0005106Moderately InformativeDirect
Cellular componentCell projection0.5054Moderately InformativeInherited
Cellular componentCilium0.0002322InformativeDirect
Cellular componentLipid droplet0.0000000001181Highly InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Molecular functionNADP0InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationChaperone0InformativeDirect
Post-translational modificationAcetylation0.00000000000003415Least InformativeDirect
Post-translational modificationPhosphopantetheine0Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)amino-acid metabolism0Least InformativeDirect
UniPathway (UP)aromatic compound metabolism0.5294Least InformativeInherited
UniPathway (UP)biopolymer metabolism1Least InformativeInherited
UniPathway (UP)carbohydrate metabolism1Least InformativeInherited
UniPathway (UP)amino-acid degradation0Moderately InformativeDirect
UniPathway (UP)aromatic compound biosynthesis0Moderately InformativeDirect
UniPathway (UP)antibiotic biosynthesis0.00000001118Moderately InformativeDirect
UniPathway (UP)secondary metabolite metabolism0.0009607Moderately InformativeDirect
UniPathway (UP)organic acid metabolism0.002556Moderately InformativeInherited
UniPathway (UP)alcohol metabolism0.06952Moderately InformativeInherited
UniPathway (UP)carbohydrate degradation0.2259Moderately InformativeInherited
UniPathway (UP)biopolymer biosynthesis1Moderately InformativeInherited
UniPathway (UP)metabolic intermediate biosynthesis1Moderately InformativeInherited
UniPathway (UP)cell wall metabolism1Moderately InformativeInherited
UniPathway (UP)cellular component biogenesis1Moderately InformativeInherited
UniPathway (UP)phenylpropanoid biosynthesis0InformativeDirect
UniPathway (UP)organic acid biosynthesis0.004215InformativeInherited
UniPathway (UP)polyketide biosynthesis0.01816InformativeInherited
UniPathway (UP)L-threonine degradation0Highly InformativeDirect
UniPathway (UP)2-deoxystreptamine biosynthesis0.000000000000006726Highly InformativeDirect
UniPathway (UP)teichoic acid biosynthesis0.00000008117Highly InformativeDirect
UniPathway (UP)aminoglycoside antibiotic biosynthesis0.000003271Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR011032 SSF50129 Protein matches
Abstract

GroES (chaperonin 10) is an oligomeric molecular chaperone, which functions in protein folding and possibly in intercellular signalling, being found on the surface of various prokaryotic and eukaryotic cells, as well as being released from cells. Secreted chaperonins are thought to act as intercellular signals, interacting with a variety of cell types, including leukocytes, vascular endothelial cells and epithelial cells, as well as activating key cellular activities such as the synthesis of cytokines and adhesion proteins [PubMed14585136]. GroES works as a co-chaperone with GroEL (chaperonin 60) during protein folding. The polypeptide substrate is captured by GroEL, which bind the co-chaperone GroES and ATP, and discharges the substrate into a unique microenvironment inside of the chaperone, which promotes productive folding. After hydrolysis of ATP, the polypeptide is released into solution [PubMed12475168]. GP31 from Bacteriophage T4 is functionally equivalent to GroES. GroES folds as a partly opened beta-barrel.

The N-terminal domain of alcohol dehydrogenase-like proteins have a GroES-like fold, the C-terminal domain having a classical Rossman-fold [PubMed11274460]. These proteins include, alcohol dehydrogenase, which contains a zinc-finger subdomain within the GroES-like domain, ketose reductase (sorbitol dehydrogenase), formaldehyde dehydrogenase, quinone oxidoreductase and 2,4-dienoyl-CoA reductase.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 36 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a GroES-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 36 hidden Markov models representing the GroES-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]