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PDZ domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   PDZ domain-like [ 50155]
Superfamily:   PDZ domain-like [ 50156] (6)
Families:   PDZ domain [ 50157] (46)
  Tail specific protease PDZ domain [ 68933] (2)
  HtrA-like serine proteases [ 74933] (4)
  Interleukin 16 [ 50172]
  EpsC C-terminal domain-like [ 159046]
  MTH1368 C-terminal domain-like [ 159049]


Superfamily statistics
Genomes (3,127) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 56,247 212,268 117
Proteins 37,943 153,416 112


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process0.00068750Least InformativeDirect
Biological Process (BP)biological regulation0.013420Least InformativeInherited
Biological Process (BP)response to stimulus0.053280.00002181Least InformativeInherited
Biological Process (BP)regulation of biological quality0.10340Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.056090.0000007776Moderately InformativeInherited
Biological Process (BP)tissue development0.1290.000000001409Moderately InformativeInherited
Biological Process (BP)regulation of signaling0.0048190Moderately InformativeInherited
Biological Process (BP)regulation of cell communication0.0079330Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.03190.5594Moderately InformativeInherited
Biological Process (BP)single organism signaling0.02380Moderately InformativeInherited
Biological Process (BP)cell communication0.0081560Moderately InformativeInherited
Biological Process (BP)regulation of anatomical structure size0.0000050520.000004179InformativeDirect
Biological Process (BP)negative regulation of signaling0.00003140.0000004017InformativeDirect
Biological Process (BP)negative regulation of cell communication0.00003140.00001185InformativeDirect
Biological Process (BP)epithelium development0.00022180InformativeDirect
Biological Process (BP)growth0.00033530.00000000001976InformativeDirect
Biological Process (BP)intracellular signal transduction0.035440.000008505InformativeInherited
Biological Process (BP)small GTPase mediated signal transduction0.0000040490.0003788Highly InformativeDirect
Biological Process (BP)developmental growth involved in morphogenesis0.0005770.0000003541Highly InformativeDirect
Molecular Function (MF)binding0.0080370Least InformativeInherited
Cellular Component (CC)membrane0.0054510Least InformativeInherited
Cellular Component (CC)plasma membrane0.00024140Moderately InformativeDirect
Cellular Component (CC)plasma membrane region0.000019050InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) response to stimulus 0.00002181 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.0000000000007642 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of localization 0.000000000002408 Moderately Informative Direct
Biological Process (BP) regulation of signaling 0 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 0 Moderately Informative Direct
Biological Process (BP) cell communication 0 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0.000001124 Moderately Informative Direct
Biological Process (BP) single organism signaling 0 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.0000007776 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0 Moderately Informative Direct
Biological Process (BP) tissue development 0.000000001409 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0 Moderately Informative Direct
Biological Process (BP) cellular localization 0.000000000001235 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.0000000004261 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.000000002377 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.0000002272 Moderately Informative Direct
Biological Process (BP) cellular component assembly 0.0000003885 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 0.000004842 Moderately Informative Direct
Biological Process (BP) nitrogen compound transport 0.0005562 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.5594 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.211 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.1661 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.07192 Moderately Informative Inherited
Biological Process (BP) animal organ development 0.3163 Moderately Informative Inherited
Biological Process (BP) reproduction 0.0342 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.06454 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.06461 Moderately Informative Inherited
Biological Process (BP) protein complex biogenesis 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.9639 Moderately Informative Inherited
Biological Process (BP) defense response 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.000004179 Informative Direct
Biological Process (BP) negative regulation of signaling 0.0000004017 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.00001185 Informative Direct
Biological Process (BP) epithelium development 0 Informative Direct
Biological Process (BP) growth 0.00000000001976 Informative Direct
Biological Process (BP) intracellular signal transduction 0.000008505 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0 Informative Direct
Biological Process (BP) behavior 0 Informative Direct
Biological Process (BP) supramolecular fiber organization 0.00000000000007302 Informative Direct
Biological Process (BP) cell development 0.000000000002114 Informative Direct
Biological Process (BP) positive regulation of transport 0.0000000001837 Informative Direct
Biological Process (BP) regulation of protein modification process 0.0000000005168 Informative Direct
Biological Process (BP) regulation of nervous system development 0.0000000005366 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.000000018 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0.00000005935 Informative Direct
Biological Process (BP) microtubule-based process 0.00000009453 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.0000001269 Informative Direct
Biological Process (BP) secretion by cell 0.0000001616 Informative Direct
Biological Process (BP) multi-organism reproductive process 0.0000001668 Informative Direct
Biological Process (BP) embryo development 0.0000003434 Informative Direct
Biological Process (BP) phosphorylation 0.000001871 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.000003474 Informative Direct
Biological Process (BP) organelle localization 0.00000543 Informative Direct
Biological Process (BP) regulation of transmembrane transport 0.00007012 Informative Direct
Biological Process (BP) actin cytoskeleton organization 0.00008114 Informative Direct
Biological Process (BP) regulation of hydrolase activity 0.00009551 Informative Direct
Biological Process (BP) regulation of ion transport 0.00009792 Informative Direct
Biological Process (BP) single-organism membrane organization 0.0001002 Informative Direct
Biological Process (BP) regulation of growth 0.000103 Informative Direct
Biological Process (BP) animal organ morphogenesis 0.0005596 Informative Direct
Biological Process (BP) positive regulation of developmental process 0.7074 Informative Inherited
Biological Process (BP) regulation of cellular localization 0.8951 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.7927 Informative Inherited
Biological Process (BP) regulation of transferase activity 1 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.5654 Informative Inherited
Biological Process (BP) regulation of phosphorylation 1 Informative Inherited
Biological Process (BP) regulation of locomotion 0.002096 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.002334 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.00341 Informative Inherited
Biological Process (BP) regulation of protein localization 0.822 Informative Inherited
Biological Process (BP) negative regulation of cellular protein metabolic process 0.0709 Informative Inherited
Biological Process (BP) regulation of catabolic process 0.9586 Informative Inherited
Biological Process (BP) regulation of proteolysis 1 Informative Inherited
Biological Process (BP) intracellular transport 0.03603 Informative Inherited
Biological Process (BP) organelle assembly 0.8723 Informative Inherited
Biological Process (BP) system process 0.3005 Informative Inherited
Biological Process (BP) regulation of peptide transport 1 Informative Inherited
Biological Process (BP) post-embryonic development 1 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 1 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.9986 Informative Inherited
Biological Process (BP) response to organic cyclic compound 1 Informative Inherited
Biological Process (BP) response to nitrogen compound 1 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) regulation of cell cycle 0.4434 Informative Inherited
Biological Process (BP) cell cycle process 0.004005 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.1921 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.007911 Informative Inherited
Biological Process (BP) negative regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) regulation of cell differentiation 0.1611 Informative Inherited
Biological Process (BP) regulation of organelle organization 1 Informative Inherited
Biological Process (BP) cellular protein complex assembly 1 Informative Inherited
Biological Process (BP) response to extracellular stimulus 0.9189 Informative Inherited
Biological Process (BP) response to temperature stimulus 0.2078 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.7569 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) anion transport 0.4832 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.0647 Informative Inherited
Biological Process (BP) organic acid transport 0.1639 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 0.2408 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 0.008267 Informative Inherited
Biological Process (BP) single organism reproductive process 0.8756 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.1602 Informative Inherited
Biological Process (BP) central nervous system development 0.9888 Informative Inherited
Biological Process (BP) single-organism cellular localization 0.09735 Informative Inherited
Biological Process (BP) lipid localization 1 Informative Inherited
Biological Process (BP) localization of cell 0.01535 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.8957 Informative Inherited
Biological Process (BP) immune response 0.9747 Informative Inherited
Biological Process (BP) negative regulation of transport 0.1903 Informative Inherited
Biological Process (BP) small GTPase mediated signal transduction 0.0003788 Highly Informative Direct
Biological Process (BP) developmental growth involved in morphogenesis 0.0000003541 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 0 Highly Informative Direct
Biological Process (BP) establishment of organelle localization 0 Highly Informative Direct
Biological Process (BP) cell-cell signaling 0 Highly Informative Direct
Biological Process (BP) regulation of neurotransmitter levels 0.0000000000001833 Highly Informative Direct
Biological Process (BP) protein localization to membrane 0.000000000002974 Highly Informative Direct
Biological Process (BP) regulation of cell shape 0.00000000006418 Highly Informative Direct
Biological Process (BP) cell proliferation 0.0000000001085 Highly Informative Direct
Biological Process (BP) biological adhesion 0.0000000001355 Highly Informative Direct
Biological Process (BP) sensory organ morphogenesis 0.0000000003639 Highly Informative Direct
Biological Process (BP) multi-organism behavior 0.000000002019 Highly Informative Direct
Biological Process (BP) epithelial cell differentiation 0.00000003152 Highly Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 0.0000001505 Highly Informative Direct
Biological Process (BP) negative regulation of locomotion 0.0000003546 Highly Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0.000000408 Highly Informative Direct
Biological Process (BP) negative regulation of cellular component movement 0.000002305 Highly Informative Direct
Biological Process (BP) cell growth 0.000005287 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 0.000006914 Highly Informative Direct
Biological Process (BP) modified amino acid transport 0.000009226 Highly Informative Direct
Biological Process (BP) single-organism behavior 0.000009895 Highly Informative Direct
Biological Process (BP) neuron development 0.00003021 Highly Informative Direct
Biological Process (BP) negative regulation of mitotic cell cycle 0.0000409 Highly Informative Direct
Biological Process (BP) locomotory behavior 0.0001094 Highly Informative Direct
Biological Process (BP) tube morphogenesis 0.0001332 Highly Informative Direct
Biological Process (BP) regulation of transmembrane transporter activity 0.0002512 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.0002858 Highly Informative Direct
Biological Process (BP) sulfur compound transport 0.0005678 Highly Informative Direct
Biological Process (BP) regulation of protein polymerization 0.0006022 Highly Informative Direct
Biological Process (BP) actin filament organization 0.0008987 Highly Informative Direct
Biological Process (BP) positive regulation of nervous system development 0.05592 Highly Informative Inherited
Biological Process (BP) positive regulation of cell development 0.1996 Highly Informative Inherited
Biological Process (BP) positive regulation of cell migration 1 Highly Informative Inherited
Biological Process (BP) positive regulation of apoptotic process 0.01485 Highly Informative Inherited
Biological Process (BP) positive regulation of protein serine/threonine kinase activity 0.03305 Highly Informative Inherited
Biological Process (BP) regulation of cation transmembrane transport 1 Highly Informative Inherited
Biological Process (BP) response to growth factor 0.1432 Highly Informative Inherited
Biological Process (BP) negative regulation of nervous system development 0.6366 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.2843 Highly Informative Inherited
Biological Process (BP) regulation of intracellular protein transport 0.8639 Highly Informative Inherited
Biological Process (BP) negative regulation of catabolic process 0.1004 Highly Informative Inherited
Biological Process (BP) regulation of protein catabolic process 0.7434 Highly Informative Inherited
Biological Process (BP) microtubule cytoskeleton organization 1 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular component biogenesis 0.0161 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 0.02716 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular protein localization 0.01903 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.9679 Highly Informative Inherited
Biological Process (BP) positive regulation of protein transport 1 Highly Informative Inherited
Biological Process (BP) appendage development 0.03468 Highly Informative Inherited
Biological Process (BP) post-embryonic animal morphogenesis 0.06165 Highly Informative Inherited
Biological Process (BP) kidney development 0.3895 Highly Informative Inherited
Biological Process (BP) second-messenger-mediated signaling 0.01387 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte migration 0.2835 Highly Informative Inherited
Biological Process (BP) response to organophosphorus 0.0923 Highly Informative Inherited
Biological Process (BP) cellular response to organonitrogen compound 0.4684 Highly Informative Inherited
Biological Process (BP) negative regulation of protein modification process 0.2736 Highly Informative Inherited
Biological Process (BP) negative regulation of phosphate metabolic process 0.3223 Highly Informative Inherited
Biological Process (BP) response to purine-containing compound 0.1606 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.01318 Highly Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 1 Highly Informative Inherited
Biological Process (BP) regulation of microtubule-based process 0.7553 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular signal transduction 0.01327 Highly Informative Inherited
Biological Process (BP) MAPK cascade 0.002046 Highly Informative Inherited
Biological Process (BP) negative regulation of cytoskeleton organization 0.141 Highly Informative Inherited
Biological Process (BP) response to mechanical stimulus 0.007365 Highly Informative Inherited
Biological Process (BP) nervous system process 0.5964 Highly Informative Inherited
Biological Process (BP) negative regulation of cell development 1 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.1142 Highly Informative Inherited
Biological Process (BP) regulation of cell size 1 Highly Informative Inherited
Biological Process (BP) regulation of cell growth 1 Highly Informative Inherited
Biological Process (BP) plasma membrane bounded cell projection organization 0.07981 Highly Informative Inherited
Biological Process (BP) pigmentation 0.005597 Highly Informative Inherited
Biological Process (BP) anatomical structure homeostasis 0.09203 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.02082 Highly Informative Inherited
Biological Process (BP) regulation of blood pressure 0.6558 Highly Informative Inherited
Biological Process (BP) cell maturation 0.03879 Highly Informative Inherited
Biological Process (BP) anatomical structure maturation 0.07164 Highly Informative Inherited
Biological Process (BP) regulation of GTPase activity 0.002303 Highly Informative Inherited
Biological Process (BP) response to nutrient levels 1 Highly Informative Inherited
Biological Process (BP) cellular response to extracellular stimulus 1 Highly Informative Inherited
Biological Process (BP) negative regulation of supramolecular fiber organization 0.1157 Highly Informative Inherited
Biological Process (BP) regulation of actin polymerization or depolymerization 0.07772 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.04866 Highly Informative Inherited
Biological Process (BP) monocarboxylic acid transport 0.008826 Highly Informative Inherited
Biological Process (BP) organic hydroxy compound transport 0.02192 Highly Informative Inherited
Biological Process (BP) regulation of binding 1 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.0497 Highly Informative Inherited
Biological Process (BP) germ cell development 0.662 Highly Informative Inherited
Biological Process (BP) forebrain development 1 Highly Informative Inherited
Biological Process (BP) muscle system process 0.1644 Highly Informative Inherited
Biological Process (BP) gliogenesis 0.0336 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 1 Highly Informative Inherited
Biological Process (BP) muscle tissue development 0.1483 Highly Informative Inherited
Biological Process (BP) gastrulation 1 Highly Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 1 Highly Informative Inherited
Biological Process (BP) cell projection assembly 0.6961 Highly Informative Inherited
Biological Process (BP) microtubule-based movement 1 Highly Informative Inherited
Biological Process (BP) innate immune response 0.177 Highly Informative Inherited
Biological Process (BP) embryonic organ development 0.5219 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.5475 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) hydrolase activity 0.9809 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) molecular function regulator 0 Moderately Informative Direct
Molecular Function (MF) structural molecule activity 0.000000000000001615 Moderately Informative Direct
Molecular Function (MF) anion binding 0.02173 Moderately Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 1 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 1 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 1 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.1193 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 1 Moderately Informative Inherited
Molecular Function (MF) phospholipid binding 0.000000000002875 Informative Direct
Molecular Function (MF) enzyme binding 0.000000000005847 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0.00000000002598 Informative Direct
Molecular Function (MF) receptor binding 0.0000000004982 Informative Direct
Molecular Function (MF) macromolecular complex binding 0.07311 Informative Inherited
Molecular Function (MF) protein dimerization activity 1 Informative Inherited
Molecular Function (MF) ATPase activity 1 Informative Inherited
Molecular Function (MF) ribonucleotide binding 0.6276 Informative Inherited
Molecular Function (MF) purine nucleotide binding 0.8184 Informative Inherited
Molecular Function (MF) kinase activity 0.005169 Informative Inherited
Molecular Function (MF) peptidase activity, acting on L-amino acid peptides 1 Informative Inherited
Molecular Function (MF) enzyme activator activity 0.008312 Informative Inherited
Molecular Function (MF) phosphatase activity 0.3068 Informative Inherited
Molecular Function (MF) phosphotransferase activity, phosphate group as acceptor 0 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0 Highly Informative Direct
Molecular Function (MF) nucleobase-containing compound kinase activity 0 Highly Informative Direct
Molecular Function (MF) serine hydrolase activity 0 Highly Informative Direct
Molecular Function (MF) G-protein coupled receptor binding 0.0000000009788 Highly Informative Direct
Molecular Function (MF) GTPase regulator activity 0.000000001138 Highly Informative Direct
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0.0000001938 Highly Informative Direct
Molecular Function (MF) cell adhesion molecule binding 0.0000002056 Highly Informative Direct
Molecular Function (MF) actin filament binding 0.000000379 Highly Informative Direct
Molecular Function (MF) protein heterodimerization activity 0.000177 Highly Informative Direct
Molecular Function (MF) protein phosphatase binding 1 Highly Informative Inherited
Molecular Function (MF) kinase binding 0.5812 Highly Informative Inherited
Molecular Function (MF) phosphoprotein phosphatase activity 0.004549 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.000000007282 Least Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0.0000003704 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) protein complex 0.08051 Least Informative Inherited
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0 Moderately Informative Direct
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) vesicle 0.0000000001619 Moderately Informative Direct
Cellular Component (CC) whole membrane 1 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 1 Moderately Informative Inherited
Cellular Component (CC) extracellular region part 1 Moderately Informative Inherited
Cellular Component (CC) bounding membrane of organelle 0.4034 Moderately Informative Inherited
Cellular Component (CC) membrane protein complex 1 Moderately Informative Inherited
Cellular Component (CC) intrinsic component of membrane 1 Moderately Informative Inherited
Cellular Component (CC) plasma membrane region 0 Informative Direct
Cellular Component (CC) apical part of cell 0 Informative Direct
Cellular Component (CC) supramolecular polymer 0 Informative Direct
Cellular Component (CC) cytoplasmic region 0 Informative Direct
Cellular Component (CC) actin cytoskeleton 0.0000009172 Informative Direct
Cellular Component (CC) cilium 0.0001291 Informative Direct
Cellular Component (CC) membrane region 0.3162 Informative Inherited
Cellular Component (CC) side of membrane 1 Informative Inherited
Cellular Component (CC) extracellular organelle 0.006613 Informative Inherited
Cellular Component (CC) extracellular space 1 Informative Inherited
Cellular Component (CC) plasma membrane bounded cell projection part 0.001328 Informative Inherited
Cellular Component (CC) neuron projection 0.03011 Informative Inherited
Cellular Component (CC) plasma membrane protein complex 0.7467 Informative Inherited
Cellular Component (CC) transporter complex 0.01643 Informative Inherited
Cellular Component (CC) contractile ring 0.000000000000005967 Highly Informative Direct
Cellular Component (CC) basal part of cell 0.000000003868 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 0.0001055 Highly Informative Direct
Cellular Component (CC) outer membrane-bounded periplasmic space 0.0002339 Highly Informative Direct
Cellular Component (CC) exocytic vesicle 0.0003294 Highly Informative Direct
Cellular Component (CC) cortical cytoskeleton 0.0003633 Highly Informative Direct
Cellular Component (CC) receptor complex 0.0004714 Highly Informative Direct
Cellular Component (CC) extracellular exosome 0.0005591 Highly Informative Direct
Cellular Component (CC) motile cilium 0.2432 Highly Informative Inherited
Cellular Component (CC) presynapse 0.01379 Highly Informative Inherited
Cellular Component (CC) dendrite 0.2012 Highly Informative Inherited
Cellular Component (CC) intrinsic component of plasma membrane 1 Highly Informative Inherited
Cellular Component (CC) cell-substrate adherens junction 1 Highly Informative Inherited
Cellular Component (CC) cell-cell junction 0.001399 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0.0003073Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.0004756Moderately InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0.0000000007522InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation0.0000003399InformativeDirect
Enzyme Commission (EC)Metalloendopeptidases0.3199InformativeInherited
Enzyme Commission (EC)Nitric-oxide synthase0.0000000000001896Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processApoptosis0Moderately InformativeDirect
Biological processDifferentiation0Moderately InformativeDirect
Biological processProtein transport0.00000000000561Moderately InformativeDirect
Biological processLipid metabolism1Moderately InformativeInherited
Biological processWnt signaling pathway0InformativeDirect
Biological processNeurogenesis0.0000000000000296InformativeDirect
Biological processStress response0.0000006166InformativeDirect
Biological processChemotaxis0.00003463InformativeDirect
Biological processCell adhesion0.00006158InformativeDirect
Biological processSteroid metabolism0.00187InformativeInherited
Biological processExocytosis0Highly InformativeDirect
Biological processCilium biogenesis/degradation0.00000000000136Highly InformativeDirect
Biological processOsteogenesis0.0000003989Highly InformativeDirect
Biological processNeurotransmitter transport0.000001876Highly InformativeDirect
Biological processCholesterol metabolism0.00008961Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentCell membrane0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.00008174Moderately InformativeDirect
Cellular componentEndosome0.0001728Moderately InformativeDirect
Cellular componentGolgi apparatus0.0006334Moderately InformativeDirect
Cellular componentPeriplasm0.0000000007243InformativeDirect
Cellular componentSynapse1InformativeInherited
Cellular componentTight junction0Highly InformativeDirect
Cellular componentPostsynaptic cell membrane0.00002163Highly InformativeDirect
Cellular componentSynaptosome0.0001965Highly InformativeDirect
Coding sequence diversityAlternative splicing0.0000000000001416Least InformativeDirect
DiseaseDeafness0.00034InformativeDirect
DomainRepeat0Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainCoiled coil0.00004783Moderately InformativeDirect
DomainSH3 domain0InformativeDirect
DomainSH3-binding0.0007703InformativeDirect
DomainLIM domain0Highly InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionLipid-binding0.000003515Moderately InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationKinase1Moderately InformativeInherited
Post-translational modificationActin-binding0InformativeDirect
Post-translational modificationCalmodulin-binding0InformativeDirect
Post-translational modificationGTPase activation0InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor0InformativeDirect
Post-translational modificationSerine protease0InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0.00000009384InformativeDirect
Post-translational modificationGrowth factor binding0.0000000000001263Highly InformativeDirect
Post-translational modificationSignal transduction inhibitor0.000001566Highly InformativeDirect
Post-translational modificationCytokine0.000035Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR001478 SSF50156 Protein matches
Abstract

PDZ domains are found in diverse signaling proteins in bacteria, yeasts, plants, insects and vertebrates [PubMed9041651, PubMed9204764]. PDZ domains can occur in one or multiple copies and are nearly always found in cytoplasmic proteins. They bind either the carboxyl-terminal sequences of proteins or internal peptide sequences [PubMed9204764]. In most cases, interaction between a PDZ domain and its target is constitutive, with a binding affinity of 1 to 10 żM. However, agonist-dependent activation of cell surface receptors is sometimes required to promote interaction with a PDZ protein. PDZ domain proteins are frequently associated with the plasma membrane, a compartment where high concentrations of phosphatidylinositol 4,5-bisphosphate (PIP2) are found. Direct interaction between PIP2 and a subset of class II PDZ domains (syntenin, CASK, Tiam-1) has been demonstrated.

PDZ domains consist of 80 to 90 amino acids comprising six beta-strands (betaA to betaF) and two alpha-helices, A and B, compactly arranged in a globular structure. Peptide binding of the ligand takes place in an elongated surface groove as an antiparallel beta-strand interacts with the betaB strand and the B helix. The structure of PDZ domains allows binding to a free carboxylate group at the end of a peptide through a carboxylate-binding loop between the betaA and betaB strands.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 79 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a PDZ domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 79 hidden Markov models representing the PDZ domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]