SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.


PDZ domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   PDZ domain-like [ 50155]
Superfamily:   PDZ domain-like [ 50156] (6)
Families:   PDZ domain [ 50157] (46)
  Tail specific protease PDZ domain [ 68933] (2)
  HtrA-like serine proteases [ 74933] (4)
  Interleukin 16 [ 50172]
  EpsC C-terminal domain-like [ 159046]
  MTH1368 C-terminal domain-like [ 159049]


Superfamily statistics
Genomes (3,125) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 55,559 212,268 117
Proteins 37,547 153,416 112


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biological regulation0.0065950Least InformativeInherited
Biological Process (BP)response to stimulus0.029260.0000006026Least InformativeInherited
Biological Process (BP)regulation of biological quality0.10590Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.014640.00000003937Moderately InformativeInherited
Biological Process (BP)regulation of signaling0.0050710Moderately InformativeInherited
Biological Process (BP)regulation of cell communication0.0083240Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.033320.1975Moderately InformativeInherited
Biological Process (BP)cell communication0.0042950Moderately InformativeInherited
Biological Process (BP)single organism signaling0.015550Moderately InformativeInherited
Biological Process (BP)regulation of anatomical structure size0.000003290.0000002249InformativeDirect
Biological Process (BP)negative regulation of signaling0.000020570.00000001085InformativeDirect
Biological Process (BP)negative regulation of cell communication0.000020570.0000004598InformativeDirect
Biological Process (BP)growth0.00019560.000000002969InformativeDirect
Biological Process (BP)intracellular signal transduction0.037250.00002646InformativeInherited
Biological Process (BP)developmental growth involved in morphogenesis0.00068270.000017Highly InformativeDirect
Biological Process (BP)small GTPase mediated signal transduction0.0000025780.004709Highly InformativeInherited
Molecular Function (MF)binding0.0022610Least InformativeInherited
Cellular Component (CC)membrane0.0026570Least InformativeInherited
Cellular Component (CC)plasma membrane0.00024090Moderately InformativeDirect
Cellular Component (CC)plasma membrane region0.000019770InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) response to stimulus 0.0000006026 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.0000000001024 Least Informative Direct
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of localization 0.000000000001359 Moderately Informative Direct
Biological Process (BP) cell communication 0 Moderately Informative Direct
Biological Process (BP) regulation of signaling 0 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 0 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0.00001073 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.00000003937 Moderately Informative Direct
Biological Process (BP) single organism signaling 0 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0 Moderately Informative Direct
Biological Process (BP) cellular developmental process 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.000000000978 Moderately Informative Direct
Biological Process (BP) cellular localization 0.000000001124 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.00000001319 Moderately Informative Direct
Biological Process (BP) cellular component assembly 0.00000009756 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.0000003083 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 0.0000009137 Moderately Informative Direct
Biological Process (BP) nitrogen compound transport 0.00009599 Moderately Informative Direct
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) system development 0.07188 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.1975 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) protein complex biogenesis 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.03046 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.1601 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.02018 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.3209 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.8616 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.04443 Moderately Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.0000002249 Informative Direct
Biological Process (BP) negative regulation of signaling 0.00000001085 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.0000004598 Informative Direct
Biological Process (BP) growth 0.000000002969 Informative Direct
Biological Process (BP) intracellular signal transduction 0.00002646 Informative Direct
Biological Process (BP) cell-cell signaling 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) cytoskeleton organization 0 Informative Direct
Biological Process (BP) actin filament-based process 0 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0 Informative Direct
Biological Process (BP) behavior 0 Informative Direct
Biological Process (BP) supramolecular fiber organization 0.0000000000001685 Informative Direct
Biological Process (BP) cell development 0.00000000008681 Informative Direct
Biological Process (BP) regulation of nervous system development 0.0000000001072 Informative Direct
Biological Process (BP) positive regulation of transport 0.000000000134 Informative Direct
Biological Process (BP) tissue development 0.0000000001672 Informative Direct
Biological Process (BP) regulation of protein modification process 0.000000002774 Informative Direct
Biological Process (BP) sensory organ development 0.000000005061 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0.000000005905 Informative Direct
Biological Process (BP) multi-organism reproductive process 0.0000001898 Informative Direct
Biological Process (BP) embryo development 0.0000002212 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.0000002624 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.0000005231 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.000001012 Informative Direct
Biological Process (BP) microtubule-based process 0.000001671 Informative Direct
Biological Process (BP) phosphorylation 0.00003516 Informative Direct
Biological Process (BP) regulation of growth 0.00005339 Informative Direct
Biological Process (BP) regulation of transmembrane transport 0.00007022 Informative Direct
Biological Process (BP) secretion by cell 0.0000935 Informative Direct
Biological Process (BP) regulation of hydrolase activity 0.0001038 Informative Direct
Biological Process (BP) regulation of ion transport 0.0001076 Informative Direct
Biological Process (BP) proteolysis 0.0005653 Informative Direct
Biological Process (BP) organelle localization 0.0007273 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.0008063 Informative Direct
Biological Process (BP) regulation of locomotion 0.0008141 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.6805 Informative Inherited
Biological Process (BP) regulation of transferase activity 1 Informative Inherited
Biological Process (BP) regulation of phosphorylation 1 Informative Inherited
Biological Process (BP) positive regulation of cell death 0.128 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.01828 Informative Inherited
Biological Process (BP) regulation of catabolic process 0.8895 Informative Inherited
Biological Process (BP) regulation of proteolysis 1 Informative Inherited
Biological Process (BP) cell cycle process 0.0108 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.9218 Informative Inherited
Biological Process (BP) organelle assembly 0.9048 Informative Inherited
Biological Process (BP) membrane organization 1 Informative Inherited
Biological Process (BP) regulation of establishment of protein localization 1 Informative Inherited
Biological Process (BP) regulation of peptide transport 1 Informative Inherited
Biological Process (BP) regulation of cellular localization 0.7942 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.001002 Informative Inherited
Biological Process (BP) post-embryonic development 1 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 1 Informative Inherited
Biological Process (BP) response to nitrogen compound 1 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.9929 Informative Inherited
Biological Process (BP) response to organic cyclic compound 1 Informative Inherited
Biological Process (BP) regulation of cell differentiation 0.1078 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 0.0206 Informative Inherited
Biological Process (BP) regulation of organelle organization 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.04488 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.00144 Informative Inherited
Biological Process (BP) cell death 1 Informative Inherited
Biological Process (BP) negative regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) cellular protein complex assembly 1 Informative Inherited
Biological Process (BP) response to extracellular stimulus 0.8675 Informative Inherited
Biological Process (BP) response to temperature stimulus 0.1168 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.5405 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.306 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.572 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 0.1283 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 1 Informative Inherited
Biological Process (BP) single organism reproductive process 0.8679 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.8264 Informative Inherited
Biological Process (BP) central nervous system development 0.7617 Informative Inherited
Biological Process (BP) single-organism intracellular transport 0.005322 Informative Inherited
Biological Process (BP) anion transport 0.4135 Informative Inherited
Biological Process (BP) organic acid transport 0.09402 Informative Inherited
Biological Process (BP) lipid localization 1 Informative Inherited
Biological Process (BP) system process 0.1258 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.05733 Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 1 Informative Inherited
Biological Process (BP) regulation of cell cycle 0.3135 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.09367 Informative Inherited
Biological Process (BP) immune response 0.9507 Informative Inherited
Biological Process (BP) negative regulation of transport 0.1828 Informative Inherited
Biological Process (BP) developmental growth involved in morphogenesis 0.000017 Highly Informative Direct
Biological Process (BP) trans-synaptic signaling 0 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 0 Highly Informative Direct
Biological Process (BP) protein localization to membrane 0.0000000000002998 Highly Informative Direct
Biological Process (BP) multi-organism behavior 0.0000000009038 Highly Informative Direct
Biological Process (BP) biological adhesion 0.000000002435 Highly Informative Direct
Biological Process (BP) cell proliferation 0.000000006655 Highly Informative Direct
Biological Process (BP) regulation of neurotransmitter levels 0.000000009058 Highly Informative Direct
Biological Process (BP) sensory organ morphogenesis 0.0000000143 Highly Informative Direct
Biological Process (BP) epithelial cell differentiation 0.00000001604 Highly Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 0.00000003447 Highly Informative Direct
Biological Process (BP) inner ear development 0.0000001002 Highly Informative Direct
Biological Process (BP) regulation of cell shape 0.0000002654 Highly Informative Direct
Biological Process (BP) negative regulation of locomotion 0.0000002723 Highly Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0.0000004191 Highly Informative Direct
Biological Process (BP) single-organism behavior 0.000001381 Highly Informative Direct
Biological Process (BP) negative regulation of cellular component movement 0.000001826 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 0.000005515 Highly Informative Direct
Biological Process (BP) modified amino acid transport 0.000009217 Highly Informative Direct
Biological Process (BP) negative regulation of mitotic cell cycle 0.00004596 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.00009406 Highly Informative Direct
Biological Process (BP) locomotory behavior 0.0001005 Highly Informative Direct
Biological Process (BP) tube morphogenesis 0.0001831 Highly Informative Direct
Biological Process (BP) regulation of transmembrane transporter activity 0.0002139 Highly Informative Direct
Biological Process (BP) sulfur compound transport 0.0003113 Highly Informative Direct
Biological Process (BP) embryo development ending in birth or egg hatching 0.0003138 Highly Informative Direct
Biological Process (BP) muscle structure development 0.000389 Highly Informative Direct
Biological Process (BP) neuron development 0.0004278 Highly Informative Direct
Biological Process (BP) cell growth 0.0005064 Highly Informative Direct
Biological Process (BP) regulation of protein polymerization 0.0005621 Highly Informative Direct
Biological Process (BP) cell division 0.0008895 Highly Informative Direct
Biological Process (BP) positive regulation of transporter activity 0.0009556 Highly Informative Direct
Biological Process (BP) positive regulation of nervous system development 0.03315 Highly Informative Inherited
Biological Process (BP) positive regulation of cell development 0.1219 Highly Informative Inherited
Biological Process (BP) positive regulation of cell migration 1 Highly Informative Inherited
Biological Process (BP) positive regulation of protein serine/threonine kinase activity 0.03801 Highly Informative Inherited
Biological Process (BP) regulation of cation transmembrane transport 1 Highly Informative Inherited
Biological Process (BP) positive regulation of apoptotic process 0.008805 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 0.07248 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.194 Highly Informative Inherited
Biological Process (BP) regulation of proteolysis involved in cellular protein catabolic process 0.007592 Highly Informative Inherited
Biological Process (BP) negative regulation of catabolic process 0.07742 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular component biogenesis 0.01156 Highly Informative Inherited
Biological Process (BP) renal system process 0.5372 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 0.01262 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular protein localization 0.01976 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.9661 Highly Informative Inherited
Biological Process (BP) positive regulation of protein transport 1 Highly Informative Inherited
Biological Process (BP) appendage development 0.04681 Highly Informative Inherited
Biological Process (BP) post-embryonic animal morphogenesis 0.08603 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.0163 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte migration 0.2793 Highly Informative Inherited
Biological Process (BP) chemotaxis 0.03086 Highly Informative Inherited
Biological Process (BP) kidney development 0.4555 Highly Informative Inherited
Biological Process (BP) response to organophosphorus 0.07811 Highly Informative Inherited
Biological Process (BP) cellular response to organonitrogen compound 0.4359 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular signal transduction 0.004975 Highly Informative Inherited
Biological Process (BP) negative regulation of protein modification process 0.1772 Highly Informative Inherited
Biological Process (BP) negative regulation of phosphate metabolic process 0.2159 Highly Informative Inherited
Biological Process (BP) response to purine-containing compound 0.1386 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 1 Highly Informative Inherited
Biological Process (BP) plasma membrane bounded cell projection organization 0.07434 Highly Informative Inherited
Biological Process (BP) regulation of microtubule-based process 0.6741 Highly Informative Inherited
Biological Process (BP) negative regulation of supramolecular fiber organization 0.1191 Highly Informative Inherited
Biological Process (BP) negative regulation of cytoskeleton organization 0.08815 Highly Informative Inherited
Biological Process (BP) response to mechanical stimulus 0.004009 Highly Informative Inherited
Biological Process (BP) neurological system process 0.4833 Highly Informative Inherited
Biological Process (BP) negative regulation of nervous system development 0.5233 Highly Informative Inherited
Biological Process (BP) negative regulation of cell development 1 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.1455 Highly Informative Inherited
Biological Process (BP) regulation of cell size 1 Highly Informative Inherited
Biological Process (BP) regulation of cell growth 1 Highly Informative Inherited
Biological Process (BP) anatomical structure homeostasis 0.07054 Highly Informative Inherited
Biological Process (BP) regulation of blood pressure 0.5744 Highly Informative Inherited
Biological Process (BP) regulation of GTPase activity 0.002091 Highly Informative Inherited
Biological Process (BP) pigmentation 0.01675 Highly Informative Inherited
Biological Process (BP) cellular response to extracellular stimulus 1 Highly Informative Inherited
Biological Process (BP) response to nutrient levels 1 Highly Informative Inherited
Biological Process (BP) microtubule cytoskeleton organization 1 Highly Informative Inherited
Biological Process (BP) regulation of actin polymerization or depolymerization 0.09265 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.2035 Highly Informative Inherited
Biological Process (BP) monocarboxylic acid transport 0.008408 Highly Informative Inherited
Biological Process (BP) organic hydroxy compound transport 0.01083 Highly Informative Inherited
Biological Process (BP) regulation of binding 1 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 1 Highly Informative Inherited
Biological Process (BP) germ cell development 0.3718 Highly Informative Inherited
Biological Process (BP) brain development 0.1036 Highly Informative Inherited
Biological Process (BP) muscle system process 0.1772 Highly Informative Inherited
Biological Process (BP) gliogenesis 0.07518 Highly Informative Inherited
Biological Process (BP) gastrulation 1 Highly Informative Inherited
Biological Process (BP) cell maturation 0.5625 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.01596 Highly Informative Inherited
Biological Process (BP) signal release 0.01067 Highly Informative Inherited
Biological Process (BP) small GTPase mediated signal transduction 0.004709 Highly Informative Inherited
Biological Process (BP) MAPK cascade 0.04513 Highly Informative Inherited
Biological Process (BP) cell projection assembly 0.6272 Highly Informative Inherited
Biological Process (BP) vesicle localization 0.4749 Highly Informative Inherited
Biological Process (BP) innate immune response 0.1354 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 0.5943 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.6655 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.008345 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity 0.6029 Least Informative Inherited
Molecular Function (MF) molecular function regulator 0 Moderately Informative Direct
Molecular Function (MF) structural molecule activity 0.0000000000001125 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 1 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 1 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 1 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.113 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.02413 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 1 Moderately Informative Inherited
Molecular Function (MF) phospholipid binding 0.00000000001142 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0.0000000000404 Informative Direct
Molecular Function (MF) receptor binding 0.000000000355 Informative Direct
Molecular Function (MF) enzyme binding 0.0000000008707 Informative Direct
Molecular Function (MF) macromolecular complex binding 0.05942 Informative Inherited
Molecular Function (MF) protein dimerization activity 1 Informative Inherited
Molecular Function (MF) ATPase activity 1 Informative Inherited
Molecular Function (MF) ribonucleotide binding 0.5703 Informative Inherited
Molecular Function (MF) purine nucleotide binding 0.7694 Informative Inherited
Molecular Function (MF) kinase activity 0.005448 Informative Inherited
Molecular Function (MF) peptidase activity, acting on L-amino acid peptides 1 Informative Inherited
Molecular Function (MF) enzyme activator activity 0.00767 Informative Inherited
Molecular Function (MF) phosphatase activity 0.2497 Informative Inherited
Molecular Function (MF) phosphotransferase activity, phosphate group as acceptor 0 Highly Informative Direct
Molecular Function (MF) nucleobase-containing compound kinase activity 0 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0 Highly Informative Direct
Molecular Function (MF) serine hydrolase activity 0 Highly Informative Direct
Molecular Function (MF) GTPase regulator activity 0.0000000003316 Highly Informative Direct
Molecular Function (MF) G-protein coupled receptor binding 0.000000001664 Highly Informative Direct
Molecular Function (MF) actin filament binding 0.0000003519 Highly Informative Direct
Molecular Function (MF) cell adhesion molecule binding 0.000001461 Highly Informative Direct
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0.000006495 Highly Informative Direct
Molecular Function (MF) protein heterodimerization activity 0.0000429 Highly Informative Direct
Molecular Function (MF) protein phosphatase binding 1 Highly Informative Inherited
Molecular Function (MF) kinase binding 0.3979 Highly Informative Inherited
Molecular Function (MF) phosphoprotein phosphatase activity 0.003225 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.0000002851 Least Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0.00000246 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) macromolecular complex 0.7484 Least Informative Inherited
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0 Moderately Informative Direct
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) vesicle 0.00000003689 Moderately Informative Direct
Cellular Component (CC) whole membrane 1 Moderately Informative Inherited
Cellular Component (CC) extracellular region part 0.825 Moderately Informative Inherited
Cellular Component (CC) bounding membrane of organelle 0.589 Moderately Informative Inherited
Cellular Component (CC) intrinsic component of membrane 1 Moderately Informative Inherited
Cellular Component (CC) membrane protein complex 1 Moderately Informative Inherited
Cellular Component (CC) plasma membrane region 0 Informative Direct
Cellular Component (CC) supramolecular polymer 0 Informative Direct
Cellular Component (CC) cytoplasmic region 0 Informative Direct
Cellular Component (CC) synapse 0 Informative Direct
Cellular Component (CC) apical part of cell 0 Informative Direct
Cellular Component (CC) actin cytoskeleton 0.000001557 Informative Direct
Cellular Component (CC) cilium 0.00003527 Informative Direct
Cellular Component (CC) membrane region 0.383 Informative Inherited
Cellular Component (CC) side of membrane 1 Informative Inherited
Cellular Component (CC) plasma membrane bounded cell projection part 0.00145 Informative Inherited
Cellular Component (CC) extracellular organelle 0.003591 Informative Inherited
Cellular Component (CC) extracellular space 1 Informative Inherited
Cellular Component (CC) neuron projection 0.003144 Informative Inherited
Cellular Component (CC) plasma membrane protein complex 0.6589 Informative Inherited
Cellular Component (CC) transporter complex 0.01275 Informative Inherited
Cellular Component (CC) contractile fiber part 0 Highly Informative Direct
Cellular Component (CC) cortical actin cytoskeleton 0.00000221 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 0.00001542 Highly Informative Direct
Cellular Component (CC) lateral plasma membrane 0.00002233 Highly Informative Direct
Cellular Component (CC) receptor complex 0.0002496 Highly Informative Direct
Cellular Component (CC) outer membrane-bounded periplasmic space 0.0002673 Highly Informative Direct
Cellular Component (CC) cell-cell junction 0.0002997 Highly Informative Direct
Cellular Component (CC) motile cilium 0.2708 Highly Informative Inherited
Cellular Component (CC) extracellular vesicle 0.5344 Highly Informative Inherited
Cellular Component (CC) dendrite 0.09084 Highly Informative Inherited
Cellular Component (CC) sperm part 0.02332 Highly Informative Inherited
Cellular Component (CC) intrinsic component of plasma membrane 1 Highly Informative Inherited
Cellular Component (CC) cell-substrate adherens junction 1 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0.0003073Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.0004756Moderately InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0.0000000007522InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation0.0000003399InformativeDirect
Enzyme Commission (EC)Metalloendopeptidases0.3199InformativeInherited
Enzyme Commission (EC)Nitric-oxide synthase0.0000000000001896Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)genetic disease0.4838Moderately InformativeInherited
Disease Ontology (DO)autosomal recessive disease0.2171InformativeInherited

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.00000342Least InformativeDirect
Mammalian Phenotype (MP)abnormal nervous system physiology0.1552Moderately InformativeInherited
Mammalian Phenotype (MP)hearing/vestibular/ear phenotype0.3642Moderately InformativeInherited
Mammalian Phenotype (MP)embryo phenotype0.7781Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.83Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development0.901Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear hair cell morphology0.01152InformativeInherited
Mammalian Phenotype (MP)abnormal behavioral response to xenobiotic0.09059InformativeInherited
Mammalian Phenotype (MP)abnormal neural tube morphology0.5521InformativeInherited
Mammalian Phenotype (MP)craniorachischisis0.0001166Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cochlear hair cell stereociliary bundle morphology0.0002615Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell morphology variant0.08501Least InformativeInherited
Worm Phenotype (WP)cell development variant0.09997Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.1288Least InformativeInherited
Worm Phenotype (WP)organ system morphology variant0.1349Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.2933Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.3384Least InformativeInherited
Worm Phenotype (WP)chemical response variant0.01891Moderately InformativeInherited
Worm Phenotype (WP)nervous system morphology variant0.07144Moderately InformativeInherited
Worm Phenotype (WP)germ cell morphology variant0.4037Moderately InformativeInherited
Worm Phenotype (WP)cell component morphology variant0.4419Moderately InformativeInherited
Worm Phenotype (WP)reproductive system development variant0.676Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.7264Moderately InformativeInherited
Worm Phenotype (WP)aldicarb response variant0.000002381InformativeDirect
Worm Phenotype (WP)drug resistant0.000847InformativeDirect
Worm Phenotype (WP)vulva cell fate specification variant0.01002InformativeInherited
Worm Phenotype (WP)cell number increased0.2205InformativeInherited
Worm Phenotype (WP)epithelial system development variant0.5876InformativeInherited
Worm Phenotype (WP)oocyte morphology variant0.8089InformativeInherited
Worm Phenotype (WP)cell polarity variant0.000001209Highly InformativeDirect
Worm Phenotype (WP)presynaptic region morphology variant0.000007063Highly InformativeDirect
Worm Phenotype (WP)body muscle dystrophy0.00002954Highly InformativeDirect
Worm Phenotype (WP)vulvaless0.00009822Highly InformativeDirect
Worm Phenotype (WP)cell division polarity variant0.0002521Highly InformativeDirect
Worm Phenotype (WP)body elongation variant0.0003031Highly InformativeDirect
Worm Phenotype (WP)ovulation variant0.0003776Highly InformativeDirect
Worm Phenotype (WP)endomitotic oocytes0.0005535Highly InformativeDirect
Worm Phenotype (WP)cytoskeleton organization biogenesis variant0.005715Highly InformativeInherited
Worm Phenotype (WP)epithelial development variant0.007378Highly InformativeInherited
Worm Phenotype (WP)cell number decreased0.03397Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)cell polarity defective0.0003503InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)compound organ0.4332Least InformativeInherited
Zebrafish Anatomy (ZA)multi-tissue structure0.4379Least InformativeInherited
Zebrafish Anatomy (ZA)nervous system0.4558Least InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.4518Moderately InformativeInherited
Zebrafish Anatomy (ZA)cell0.9465Moderately InformativeInherited
Zebrafish Anatomy (ZA)central nervous system0.951Moderately InformativeInherited
Zebrafish Anatomy (ZA)ventricular system0.02382Highly InformativeInherited
Zebrafish Anatomy (ZA)spinal cord0.02981Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system0.02073Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.08198Least InformativeInherited
Xenopus ANatomical entity (XAN)brain0.0006209Moderately InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorus-containing groups0.01104Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.0008329Moderately InformativeDirect
Enzyme Commission (EC)Acyltransferases0.4544Moderately InformativeInherited
Enzyme Commission (EC)Serine endopeptidases0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0.000000001306InformativeDirect
Enzyme Commission (EC)RING-type E3 ubiquitin transferase0.00009992InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0.0003731InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0.0009634InformativeDirect
Enzyme Commission (EC)Metalloendopeptidases0.3731InformativeInherited
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation of one atom of oxygen0.000001697Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processApoptosis0Moderately InformativeDirect
Biological processDifferentiation0Moderately InformativeDirect
Biological processProtein transport0.000000000005611Moderately InformativeDirect
Biological processLipid metabolism1Moderately InformativeInherited
Biological processWnt signaling pathway0InformativeDirect
Biological processNeurogenesis0.00000000000002618InformativeDirect
Biological processStress response0.0000005796InformativeDirect
Biological processChemotaxis0.00003484InformativeDirect
Biological processCell adhesion0.0000595InformativeDirect
Biological processSteroid metabolism0.001767InformativeInherited
Biological processExocytosis0Highly InformativeDirect
Biological processCilium biogenesis/degradation0.000000000001298Highly InformativeDirect
Biological processOsteogenesis0.0000004026Highly InformativeDirect
Biological processNeurotransmitter transport0.000001894Highly InformativeDirect
Biological processCholesterol metabolism0.00008084Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentCell membrane0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.00007743Moderately InformativeDirect
Cellular componentEndosome0.0001654Moderately InformativeDirect
Cellular componentGolgi apparatus0.0006962Moderately InformativeDirect
Cellular componentPeriplasm0.0000000007808InformativeDirect
Cellular componentSynapse1InformativeInherited
Cellular componentTight junction0Highly InformativeDirect
Cellular componentPostsynaptic cell membrane0.00002425Highly InformativeDirect
Cellular componentSynaptosome0.0002126Highly InformativeDirect
Coding sequence diversityAlternative splicing0.0000000000002478Least InformativeDirect
DiseaseDeafness0.0003419InformativeDirect
DomainRepeat0Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainCoiled coil0.00005304Moderately InformativeDirect
DomainSH3 domain0InformativeDirect
DomainSH3-binding0.0007812InformativeDirect
DomainLIM domain0Highly InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionLipid-binding0.000003354Moderately InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationKinase1Moderately InformativeInherited
Post-translational modificationActin-binding0InformativeDirect
Post-translational modificationCalmodulin-binding0InformativeDirect
Post-translational modificationGTPase activation0InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor0InformativeDirect
Post-translational modificationSerine protease0InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0.00000008899InformativeDirect
Post-translational modificationGrowth factor binding0.0000000000001283Highly InformativeDirect
Post-translational modificationSignal transduction inhibitor0.000001528Highly InformativeDirect
Post-translational modificationCytokine0.0000349Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR001478 SSF50156 Protein matches
Abstract

PDZ domains are found in diverse signaling proteins in bacteria, yeasts, plants, insects and vertebrates [PubMed9041651, PubMed9204764]. PDZ domains can occur in one or multiple copies and are nearly always found in cytoplasmic proteins. They bind either the carboxyl-terminal sequences of proteins or internal peptide sequences [PubMed9204764]. In most cases, interaction between a PDZ domain and its target is constitutive, with a binding affinity of 1 to 10 żM. However, agonist-dependent activation of cell surface receptors is sometimes required to promote interaction with a PDZ protein. PDZ domain proteins are frequently associated with the plasma membrane, a compartment where high concentrations of phosphatidylinositol 4,5-bisphosphate (PIP2) are found. Direct interaction between PIP2 and a subset of class II PDZ domains (syntenin, CASK, Tiam-1) has been demonstrated.

PDZ domains consist of 80 to 90 amino acids comprising six beta-strands (betaA to betaF) and two alpha-helices, A and B, compactly arranged in a globular structure. Peptide binding of the ligand takes place in an elongated surface groove as an antiparallel beta-strand interacts with the betaB strand and the B helix. The structure of PDZ domains allows binding to a free carboxylate group at the end of a peptide through a carboxylate-binding loop between the betaA and betaB strands.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 79 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a PDZ domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 79 hidden Markov models representing the PDZ domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]