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Nucleic acid-binding proteins superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   OB-fold [ 50198] (16)
Superfamily:   Nucleic acid-binding proteins [ 50249] (16)
Families:   Anticodon-binding domain [ 50250] (2)
  RecG "wedge" domain [ 69259]
  DNA helicase RuvA subunit, N-terminal domain [ 50259]
  Single strand DNA-binding domain, SSB [ 50263] (12)
  Myf domain [ 50277] (6)
  Cold shock DNA-binding domain-like [ 50282] (30)
  TRAM domain [ 101768] (3)
  Hypothetical protein MTH1 (MT0001), insert domain [ 74955]
  DNA ligase/mRNA capping enzyme postcatalytic domain [ 50307] (5)
  Phage ssDNA-binding proteins [ 50315] (3)
  DNA replication initiator (cdc21/cdc54) N-terminal domain [ 89332]
  RNA polymerase subunit RBP8 [ 50321]
  RecO N-terminal domain-like [ 117204]
  TIP49 domain [ 141315]
  SSO2064-like [ 159109]
  RNB domain-like [ 159112] (3)


Superfamily statistics
Genomes (3,261) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 147,116 742,135 241
Proteins 113,958 588,049 208


Functional annotation
General category Information
Detailed category DNA replication/repair

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biosynthetic process0.0000000000027580Least InformativeDirect
Biological Process (BP)cellular nitrogen compound metabolic process00Least InformativeDirect
Biological Process (BP)macromolecule metabolic process00Least InformativeDirect
Biological Process (BP)primary metabolic process0.0000040510Least InformativeDirect
Biological Process (BP)organonitrogen compound metabolic process0.36371Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.19280Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.19850Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.40520Least InformativeInherited
Biological Process (BP)biological regulation0.024730.8978Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.0055180.00003688Least InformativeInherited
Biological Process (BP)response to stimulus0.084630.1277Least InformativeInherited
Biological Process (BP)peptide metabolic process00Moderately InformativeDirect
Biological Process (BP)gene expression0.00000000000001350Moderately InformativeDirect
Biological Process (BP)cellular macromolecule biosynthetic process00Moderately InformativeDirect
Biological Process (BP)amide biosynthetic process0.0000000002920Moderately InformativeDirect
Biological Process (BP)regulation of macromolecule biosynthetic process0.0020990.9321Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process0.00040360.004963Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.47310.2486Moderately InformativeInherited
Biological Process (BP)regulation of biological quality10.7311Moderately InformativeInherited
Biological Process (BP)macromolecular complex subunit organization0.0040660.09307Moderately InformativeInherited
Biological Process (BP)cellular component assembly0.54391Moderately InformativeInherited
Biological Process (BP)organelle organization0.0084910.000000000005804Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.00096970.6263Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.000017410.01607Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.68531Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.0000014630.07862Moderately InformativeInherited
Biological Process (BP)ribonucleoprotein complex subunit organization0.00000079740.0001022InformativeDirect
Biological Process (BP)posttranscriptional regulation of gene expression0.059660InformativeInherited
Biological Process (BP)ribosome biogenesis0.25780.0001735InformativeInherited
Biological Process (BP)organelle assembly0.00027291InformativeInherited
Biological Process (BP)chromosome organization0.47050InformativeInherited
Biological Process (BP)response to temperature stimulus0.00000033610.004868InformativeInherited
Biological Process (BP)translational initiation0.000000000090610.00006959Highly InformativeDirect
Biological Process (BP)response to cold00.000006804Highly InformativeDirect
Biological Process (BP)ribosome assembly0.00037630.00009636Highly InformativeDirect
Biological Process (BP)regulation of RNA stability0.000069520.0000000009805Highly InformativeDirect
Biological Process (BP)establishment of RNA localization0.00053540.0000005969Highly InformativeDirect
Biological Process (BP)regulation of protein complex disassembly0.00036230.02444Highly InformativeInherited
Molecular Function (MF)binding0.00000000053350.0000000000003626Least InformativeDirect
Molecular Function (MF)nucleic acid binding00Moderately InformativeDirect
Molecular Function (MF)structural molecule activity00Moderately InformativeDirect
Molecular Function (MF)macromolecular complex binding0.14850.7381InformativeInherited
Molecular Function (MF)DNA binding0.29011InformativeInherited
Molecular Function (MF)chromatin binding0.0000000069320.000000000000006264Highly InformativeDirect
Molecular Function (MF)single-stranded DNA binding0.0000000036920Highly InformativeDirect
Cellular Component (CC)non-membrane-bounded organelle00Least InformativeDirect
Cellular Component (CC)intracellular organelle part0.00000000031530.00000004355Least InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle10.1802Least InformativeInherited
Cellular Component (CC)protein complex11Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.013341Least InformativeInherited
Cellular Component (CC)ribosome00Moderately InformativeDirect
Cellular Component (CC)cytosolic part0.0000000088270.0000000001821Moderately InformativeDirect
Cellular Component (CC)intracellular organelle lumen0.0000000000057610Moderately InformativeDirect
Cellular Component (CC)transferase complex0.011171Moderately InformativeInherited
Cellular Component (CC)nuclear part0.26920Moderately InformativeInherited
Cellular Component (CC)mitochondrial ribosome0.00000016750.000000004626InformativeDirect
Cellular Component (CC)small ribosomal subunit00.00000202InformativeDirect
Cellular Component (CC)transferase complex, transferring phosphorus-containing groups0.000000017050.0000000005093InformativeDirect
Cellular Component (CC)protein-DNA complex0.0085520InformativeInherited
Cellular Component (CC)ribonucleoprotein granule0.031720.03109InformativeInherited
Cellular Component (CC)cytosolic ribosome0.76890.0247InformativeInherited
Cellular Component (CC)nucleoplasm part0.045240.7619InformativeInherited
Cellular Component (CC)chromosome0.62120.0000000000005018InformativeInherited
Cellular Component (CC)DNA-directed RNA polymerase II, core complex0.000044530.0000001599Highly InformativeDirect
Cellular Component (CC)mitochondrial small ribosomal subunit0.0000000000057780.0000000114Highly InformativeDirect
Cellular Component (CC)cytosolic small ribosomal subunit0.00048660.0000001467Highly InformativeDirect
Cellular Component (CC)replisome0.00000000019770Highly InformativeDirect
Cellular Component (CC)nuclear chromosome part0.001570Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0 Least Informative Direct
Biological Process (BP) biosynthetic process 0 Least Informative Direct
Biological Process (BP) cellular nitrogen compound metabolic process 0 Least Informative Direct
Biological Process (BP) macromolecule metabolic process 0 Least Informative Direct
Biological Process (BP) primary metabolic process 0 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.00003688 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biological regulation 0.8978 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.1277 Least Informative Inherited
Biological Process (BP) peptide metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular amino acid metabolic process 0.000002429 Moderately Informative Direct
Biological Process (BP) organelle organization 0.000000000005804 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 0.000191 Moderately Informative Direct
Biological Process (BP) gene expression 0 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) amide biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 0.9321 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.01607 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.6263 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.01052 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.2486 Moderately Informative Inherited
Biological Process (BP) single-organism transport 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) nitrogen compound transport 1 Moderately Informative Inherited
Biological Process (BP) animal organ development 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.196 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.004963 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.7311 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.09307 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organophosphate biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) nucleoside phosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.07862 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) immune system process 1 Moderately Informative Inherited
Biological Process (BP) DNA metabolic process 0 Informative Direct
Biological Process (BP) tRNA metabolic process 0.00003866 Informative Direct
Biological Process (BP) cellular response to DNA damage stimulus 0 Informative Direct
Biological Process (BP) response to radiation 0.0006854 Informative Direct
Biological Process (BP) posttranscriptional regulation of gene expression 0 Informative Direct
Biological Process (BP) negative regulation of gene expression 0.0003248 Informative Direct
Biological Process (BP) cell cycle process 0.0000003124 Informative Direct
Biological Process (BP) negative regulation of cellular protein metabolic process 0.0000117 Informative Direct
Biological Process (BP) regulation of cellular amide metabolic process 0.00000000000001422 Informative Direct
Biological Process (BP) ribosome biogenesis 0.0001735 Informative Direct
Biological Process (BP) single organism reproductive process 0.0003192 Informative Direct
Biological Process (BP) chromosome organization 0 Informative Direct
Biological Process (BP) ribonucleoprotein complex subunit organization 0.0001022 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0.3709 Informative Inherited
Biological Process (BP) positive regulation of gene expression 1 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 0.2033 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.3045 Informative Inherited
Biological Process (BP) regulation of catabolic process 1 Informative Inherited
Biological Process (BP) negative regulation of molecular function 1 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 0.5942 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 1 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 1 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 1 Informative Inherited
Biological Process (BP) response to organic cyclic compound 1 Informative Inherited
Biological Process (BP) organelle assembly 1 Informative Inherited
Biological Process (BP) nucleobase-containing compound catabolic process 0.002439 Informative Inherited
Biological Process (BP) protein localization to organelle 0.0036 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 1 Informative Inherited
Biological Process (BP) response to extracellular stimulus 0.2786 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.8331 Informative Inherited
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) response to nitrogen compound 1 Informative Inherited
Biological Process (BP) ncRNA processing 1 Informative Inherited
Biological Process (BP) nucleotide biosynthetic process 0.6857 Informative Inherited
Biological Process (BP) response to temperature stimulus 0.004868 Informative Inherited
Biological Process (BP) negative regulation of macromolecule biosynthetic process 0.3545 Informative Inherited
Biological Process (BP) negative regulation of cellular biosynthetic process 0.01032 Informative Inherited
Biological Process (BP) regulation of cell cycle 0.02105 Informative Inherited
Biological Process (BP) mitochondrion organization 0.9018 Informative Inherited
Biological Process (BP) cell cycle checkpoint 0.000003574 Highly Informative Direct
Biological Process (BP) DNA replication 0 Highly Informative Direct
Biological Process (BP) double-strand break repair 0.0000000000002694 Highly Informative Direct
Biological Process (BP) DNA recombination 0.000003058 Highly Informative Direct
Biological Process (BP) RNA catabolic process 0.000000000000215 Highly Informative Direct
Biological Process (BP) translational initiation 0.00006959 Highly Informative Direct
Biological Process (BP) response to cold 0.000006804 Highly Informative Direct
Biological Process (BP) response to UV 0.0003225 Highly Informative Direct
Biological Process (BP) gene silencing 0.00001117 Highly Informative Direct
Biological Process (BP) negative regulation of translation 0.000000000006153 Highly Informative Direct
Biological Process (BP) regulation of chromosome organization 0.0006767 Highly Informative Direct
Biological Process (BP) regulation of gene expression, epigenetic 0.0004104 Highly Informative Direct
Biological Process (BP) ribosome assembly 0.00009636 Highly Informative Direct
Biological Process (BP) regulation of RNA stability 0.0000000009805 Highly Informative Direct
Biological Process (BP) negative regulation of mitotic cell cycle 0.00001079 Highly Informative Direct
Biological Process (BP) regulation of DNA metabolic process 0.00000000000001763 Highly Informative Direct
Biological Process (BP) establishment of RNA localization 0.0000005969 Highly Informative Direct
Biological Process (BP) anatomical structure homeostasis 0 Highly Informative Direct
Biological Process (BP) protein-DNA complex subunit organization 0.0004146 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.2451 Highly Informative Inherited
Biological Process (BP) negative regulation of RNA metabolic process 1 Highly Informative Inherited
Biological Process (BP) nucleic acid phosphodiester bond hydrolysis 1 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular catabolic process 0.1216 Highly Informative Inherited
Biological Process (BP) meiotic cell cycle 0.08067 Highly Informative Inherited
Biological Process (BP) nuclear chromosome segregation 1 Highly Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.8086 Highly Informative Inherited
Biological Process (BP) nucleobase-containing compound transport 0.009824 Highly Informative Inherited
Biological Process (BP) modification-dependent macromolecule catabolic process 1 Highly Informative Inherited
Biological Process (BP) response to nutrient levels 1 Highly Informative Inherited
Biological Process (BP) cellular response to extracellular stimulus 0.1642 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.7784 Highly Informative Inherited
Biological Process (BP) positive regulation of homeostatic process 0.1579 Highly Informative Inherited
Biological Process (BP) regulation of protein complex disassembly 0.02444 Highly Informative Inherited
Biological Process (BP) mRNA processing 1 Highly Informative Inherited
Biological Process (BP) nuclear division 0.386 Highly Informative Inherited
Biological Process (BP) mitotic cell cycle phase transition 0.4317 Highly Informative Inherited
Molecular Function (MF) binding 0.0000000000003626 Least Informative Direct
Molecular Function (MF) hydrolase activity 0.000001244 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) nucleic acid binding 0 Moderately Informative Direct
Molecular Function (MF) structural molecule activity 0 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 0.0000004808 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.000000002751 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.1196 Moderately Informative Inherited
Molecular Function (MF) RNA binding 0.0000005047 Informative Direct
Molecular Function (MF) nuclease activity 0 Informative Direct
Molecular Function (MF) nucleotidyltransferase activity 0 Informative Direct
Molecular Function (MF) ligase activity 0 Informative Direct
Molecular Function (MF) DNA binding 1 Informative Inherited
Molecular Function (MF) macromolecular complex binding 0.7381 Informative Inherited
Molecular Function (MF) ATPase activity 0.01582 Informative Inherited
Molecular Function (MF) chromatin binding 0.000000000000006264 Highly Informative Direct
Molecular Function (MF) single-stranded DNA binding 0 Highly Informative Direct
Molecular Function (MF) sequence-specific DNA binding 1 Highly Informative Inherited
Molecular Function (MF) deoxyribonuclease activity 1 Highly Informative Inherited
Molecular Function (MF) double-stranded DNA binding 1 Highly Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.00000004355 Least Informative Direct
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.1802 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) ribosome 0 Moderately Informative Direct
Cellular Component (CC) nuclear part 0 Moderately Informative Direct
Cellular Component (CC) cytosolic part 0.0000000001821 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 0 Moderately Informative Direct
Cellular Component (CC) transferase complex 1 Moderately Informative Inherited
Cellular Component (CC) chromosome 0.0000000000005018 Informative Direct
Cellular Component (CC) mitochondrial ribosome 0.000000004626 Informative Direct
Cellular Component (CC) small ribosomal subunit 0.00000202 Informative Direct
Cellular Component (CC) protein-DNA complex 0 Informative Direct
Cellular Component (CC) transferase complex, transferring phosphorus-containing groups 0.0000000005093 Informative Direct
Cellular Component (CC) cytosolic ribosome 0.0247 Informative Inherited
Cellular Component (CC) ribonucleoprotein granule 0.03109 Informative Inherited
Cellular Component (CC) nucleoplasm part 0.7619 Informative Inherited
Cellular Component (CC) DNA-directed RNA polymerase II, core complex 0.0000001599 Highly Informative Direct
Cellular Component (CC) mitochondrial small ribosomal subunit 0.0000000114 Highly Informative Direct
Cellular Component (CC) cytosolic small ribosomal subunit 0.0000001467 Highly Informative Direct
Cellular Component (CC) replisome 0 Highly Informative Direct
Cellular Component (CC) nuclear chromosome part 0 Highly Informative Direct
Cellular Component (CC) nuclear body 1 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Nucleotidyltransferases0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0Least InformativeDirect
Enzyme Commission (EC)Ligases0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds1Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Least InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an0Moderately InformativeDirect
Enzyme Commission (EC)Ligases forming aminoacyl-tRNA and related compoun0Moderately InformativeDirect
Enzyme Commission (EC)Endoribonucleases producing 5'-phosphomonoesters1Moderately InformativeInherited
Enzyme Commission (EC)Methyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Phenylalanine--tRNA ligase0InformativeDirect
Enzyme Commission (EC)Ligases that form phosphoric-ester bonds1InformativeInherited
Enzyme Commission (EC)Aminoacyltransferases0.1092InformativeInherited
Enzyme Commission (EC)Methionine--tRNA ligase0Highly InformativeDirect
Enzyme Commission (EC)Aspartate--tRNA ligase0Highly InformativeDirect
Enzyme Commission (EC)Polyribonucleotide nucleotidyltransferase0Highly InformativeDirect
Enzyme Commission (EC)DNA ligase (NAD(+))0.0000000000006306Highly InformativeDirect
Enzyme Commission (EC)mRNA guanylyltransferase0.000000003114Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDNA damage0Moderately InformativeDirect
Biological processTranscription regulation1Moderately InformativeInherited
Biological processDNA repair0InformativeDirect
Biological processDNA recombination0InformativeDirect
Biological processDNA replication0InformativeDirect
Biological processProtein biosynthesis0InformativeDirect
Biological processTranscription termination4.846e-16Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentMitochondrion1Moderately InformativeInherited
Cellular componentChromosome1InformativeInherited
Cellular componentPrimosome0Highly InformativeDirect
Cellular componentExosome0Highly InformativeDirect
Cellular componentTelomere0.000000007442Highly InformativeDirect
Coding sequence diversityRNA editing0.0009315Moderately InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionMagnesium0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionManganese0Moderately InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationDNA-binding0Moderately InformativeDirect
Post-translational modificationNucleotidyltransferase0Moderately InformativeDirect
Post-translational modificationRNA-binding0Moderately InformativeDirect
Post-translational modificationRibonucleoprotein0Moderately InformativeDirect
Post-translational modificationNuclease0.1578Moderately InformativeInherited
Post-translational modificationAminoacyl-tRNA synthetase0InformativeDirect
Post-translational modificationRibosomal protein0InformativeDirect
Post-translational modificationInitiation factor0InformativeDirect
Post-translational modificationHelicase0InformativeDirect
Post-translational modificationExonuclease0InformativeDirect
Post-translational modificationElongation factor0Highly InformativeDirect
Post-translational modificationtRNA-binding0Highly InformativeDirect
Post-translational modificationMethylation0Moderately InformativeDirect
Post-translational modificationHydroxylation0InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 131 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Nucleic acid-binding proteins domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 131 hidden Markov models representing the Nucleic acid-binding proteins superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]