SUPERFAMILY 1.75 HMM library and genome assignments server

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MOP-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   OB-fold [ 50198] (16)
Superfamily:   MOP-like [ 50331] (3)
Families:   Molybdate/tungstate binding protein MOP [ 50332]
  BiMOP, duplicated molybdate-binding domain [ 50335] (2)
  ABC-transporter additional domain [ 50338] (4)


Superfamily statistics
Genomes (2,356) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 14,125 95,555 21
Proteins 13,511 92,107 16


Functional annotation
General category Other
Detailed category Unknown function

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) ion transport 0.00000007552 Moderately Informative Direct
Biological Process (BP) nitrogen compound transport 0.9902 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.03235 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.1731 Moderately Informative Inherited
Biological Process (BP) anion transport 0.1635 Informative Inherited
Biological Process (BP) ammonium transport 0.00000000001911 Highly Informative Direct
Biological Process (BP) organic cation transport 0.0000000002334 Highly Informative Direct
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transporter activity 0 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.0001202 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0.0006839 Moderately Informative Direct
Molecular Function (MF) anion binding 0.001857 Moderately Informative Inherited
Molecular Function (MF) P-P-bond-hydrolysis-driven transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 0 Informative Direct
Molecular Function (MF) ATPase activity 0 Informative Direct
Molecular Function (MF) active ion transmembrane transporter activity 0.000001559 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.000005164 Informative Direct
Molecular Function (MF) purine nucleotide binding 0.0000129 Informative Direct
Molecular Function (MF) ribonucleotide binding 0.00001504 Informative Direct
Molecular Function (MF) anion transmembrane transporter activity 0.000831 Informative Direct
Molecular Function (MF) ATP binding 0.0000004981 Highly Informative Direct
Molecular Function (MF) ATPase coupled ion transmembrane transporter activity 0.1414 Highly Informative Inherited
Molecular Function (MF) inorganic anion transmembrane transporter activity 0.03221 Highly Informative Inherited
Cellular Component (CC) protein complex 0.01262 Least Informative Inherited
Cellular Component (CC) membrane 0.2624 Least Informative Inherited
Cellular Component (CC) membrane protein complex 0.0000005561 Moderately Informative Direct
Cellular Component (CC) intrinsic component of membrane 0.0004961 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.02169 Moderately Informative Inherited
Cellular Component (CC) plasma membrane protein complex 0.00000000004644 Informative Direct
Cellular Component (CC) transporter complex 0.0000000002367 Informative Direct
Cellular Component (CC) ATP-binding cassette (ABC) transporter complex 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; catalyzing transmembran0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processSugar transport0Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCell membrane0Moderately InformativeDirect
Cellular componentCell inner membrane0InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionIron1Moderately InformativeInherited
Molecular functionMolybdenum0InformativeDirect
Molecular functionIron transport0Highly InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR008995 SSF50331 Protein matches
Abstract

Transport of molybdenum into bacteria involves a high-affinity ABC transporter system whose expression is controlled by a repressor protein called ModE. While molybdate transport is tightly coupled to utilization in some bacteria, other organisms have molybdenum storage proteins. One class of putative molybdate storage proteins is characterised by a sequence consisting of about 70 amino acids (Mop). A tandem repeat of Mop sequences also constitutes the molybdate binding domain of ModE.

The 7 kDa Mop protein from the methanol-utilizing anaerobe Sporomusa ovata occurs as highly symmetric hexamers binding eight oxyanions. Each peptide assumes an OB fold, which has previously also been observed in ModE. Each hexameric Mop molecule contains eight metal binding sites of two different types; all of them are only formed upon oligomer assembly, i.e., each binding site is located on the interface between two or three dimers [PubMed11080635].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 13 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a MOP-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 13 hidden Markov models representing the MOP-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]