SUPERFAMILY 1.75 HMM library and genome assignments server


Cytokine superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   beta-Trefoil [ 50352] (8)
Superfamily:   Cytokine [ 50353] (2)
Families:   Fibroblast growth factors (FGF) [ 50354] (9)
  Interleukin-1 (IL-1) [ 50362] (5)


Superfamily statistics
Genomes (130) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 2,347 2,703 61
Proteins 2,293 2,668 61


Functional annotation
General category Processes_EC
Detailed category Immune response

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process00Least InformativeDirect
Biological Process (BP)developmental process00Least InformativeDirect
Biological Process (BP)single-organism cellular process1.513e-080Least InformativeDirect
Biological Process (BP)response to stimulus4.216e-100Least InformativeDirect
Biological Process (BP)regulation of cellular process0.68060.4284Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.11511Least InformativeInherited
Biological Process (BP)localization0.18070.01668Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.68590.9385Least InformativeInherited
Biological Process (BP)immune system process0.00047250Moderately InformativeDirect
Biological Process (BP)signal transduction0.00023392.618e-14Moderately InformativeDirect
Biological Process (BP)anatomical structure morphogenesis1.205e-061.36e-06Moderately InformativeDirect
Biological Process (BP)response to endogenous stimulus00Moderately InformativeDirect
Biological Process (BP)tissue development2.411e-083.262e-09Moderately InformativeDirect
Biological Process (BP)positive regulation of metabolic process2.854e-101.081e-08Moderately InformativeDirect
Biological Process (BP)response to organic substance01.858e-05Moderately InformativeDirect
Biological Process (BP)regulation of localization3.733e-051.065e-11Moderately InformativeDirect
Biological Process (BP)positive regulation of molecular function4.902e-054.551e-05Moderately InformativeDirect
Biological Process (BP)single-organism developmental process3.152e-158.799e-12Moderately InformativeDirect
Biological Process (BP)organ development5.445e-050.0003332Moderately InformativeDirect
Biological Process (BP)positive regulation of cellular process7.186e-061.539e-11Moderately InformativeDirect
Biological Process (BP)regulation of developmental process4.731e-143.746e-15Moderately InformativeDirect
Biological Process (BP)regulation of multicellular organismal process00Moderately InformativeDirect
Biological Process (BP)cellular response to chemical stimulus2.526e-083.746e-15Moderately InformativeDirect
Biological Process (BP)cellular localization0.14150.8106Moderately InformativeInherited
Biological Process (BP)regulation of programmed cell death11Moderately InformativeInherited
Biological Process (BP)reproduction0.018390.0008646Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process4.417e-070.07949Moderately InformativeInherited
Biological Process (BP)cell differentiation00.1445Moderately InformativeInherited
Biological Process (BP)regulation of catalytic activity10.1238Moderately InformativeInherited
Biological Process (BP)regulation of phosphate metabolic process12.78e-14Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.931Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.076580.1113Moderately InformativeInherited
Biological Process (BP)positive regulation of response to stimulus0.8410.01244Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.0019190.01117Moderately InformativeInherited
Biological Process (BP)organic substance transport0.00027470.01333Moderately InformativeInherited
Biological Process (BP)nervous system development10.811Moderately InformativeInherited
Biological Process (BP)regulation of gene expression3.842e-050.8995Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.63630.6232Moderately InformativeInherited
Biological Process (BP)regulation of macromolecule biosynthetic process5.577e-080.5366Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process2.059e-070.2621Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.26230.000922Moderately InformativeInherited
Biological Process (BP)regulation of protein phosphorylation9.44e-140InformativeDirect
Biological Process (BP)regulation of transcription from RNA polymerase II promoter8.66e-071.652e-06InformativeDirect
Biological Process (BP)enzyme linked receptor protein signaling pathway00InformativeDirect
Biological Process (BP)cell-cell signaling1.237e-108.866e-13InformativeDirect
Biological Process (BP)positive regulation of cell proliferation00InformativeDirect
Biological Process (BP)response to wounding0.00099895.177e-08InformativeDirect
Biological Process (BP)positive regulation of gene expression6.234e-141.333e-11InformativeDirect
Biological Process (BP)regulation of hormone levels4.768e-070.0003692InformativeDirect
Biological Process (BP)regulation of lipid metabolic process2.276e-061.446e-08InformativeDirect
Biological Process (BP)regulation of anatomical structure morphogenesis5.388e-064.065e-06InformativeDirect
Biological Process (BP)growth6.921e-111.092e-06InformativeDirect
Biological Process (BP)regulation of locomotion1.163e-108.162e-13InformativeDirect
Biological Process (BP)positive regulation of phosphate metabolic process6.167e-151.222e-09InformativeDirect
Biological Process (BP)anatomical structure formation involved in morphogenesis0.00084566.09e-07InformativeDirect
Biological Process (BP)tissue morphogenesis8.901e-101.055e-12InformativeDirect
Biological Process (BP)positive regulation of developmental process03.773e-14InformativeDirect
Biological Process (BP)positive regulation of nitrogen compound metabolic process3.643e-109.702e-06InformativeDirect
Biological Process (BP)positive regulation of multicellular organismal process2.957e-090InformativeDirect
Biological Process (BP)regulation of cellular component movement2.537e-111.453e-13InformativeDirect
Biological Process (BP)cellular response to endogenous stimulus1.308e-051.739e-11InformativeDirect
Biological Process (BP)cardiovascular system development0.0007139.029e-06InformativeDirect
Biological Process (BP)sensory organ development0.033120.002273InformativeInherited
Biological Process (BP)epithelium development0.015860.05535InformativeInherited
Biological Process (BP)gland development0.0027060.001164InformativeInherited
Biological Process (BP)central nervous system development0.22680.2025InformativeInherited
Biological Process (BP)cytoplasmic transport0.002810.001028InformativeInherited
Biological Process (BP)regulation of cell development0.69961InformativeInherited
Biological Process (BP)positive regulation of macromolecule biosynthetic process2.664e-090.001571InformativeInherited
Biological Process (BP)positive regulation of cellular biosynthetic process1.121e-080.008752InformativeInherited
Biological Process (BP)embryo development ending in birth or egg hatching0.26830.5462InformativeInherited
Biological Process (BP)protein localization to organelle0.00066410.1939InformativeInherited
Biological Process (BP)regulation of kinase activity0.76180.2694InformativeInherited
Biological Process (BP)regulation of cytokine production0.73570.0287InformativeInherited
Biological Process (BP)organ morphogenesis0.15430.0252InformativeInherited
Biological Process (BP)embryonic organ development0.022610.000119InformativeInherited
Biological Process (BP)embryonic morphogenesis0.056444.943e-05InformativeInherited
Biological Process (BP)positive regulation of signal transduction0.0023241.518e-09InformativeInherited
Biological Process (BP)secretion by cell0.005370.1558InformativeInherited
Biological Process (BP)protein transport0.36650.1661InformativeInherited
Biological Process (BP)nitrogen compound transport0.0045880.06717InformativeInherited
Biological Process (BP)positive regulation of protein metabolic process0.11380.0004057InformativeInherited
Biological Process (BP)cellular component morphogenesis0.4570.5791InformativeInherited
Biological Process (BP)intracellular signal transduction10.182InformativeInherited
Biological Process (BP)MAPK cascade0.00076150Highly InformativeDirect
Biological Process (BP)angiogenesis3.939e-063.546e-13Highly InformativeDirect
Biological Process (BP)transmembrane receptor protein tyrosine kinase signaling pathway00Highly InformativeDirect
Biological Process (BP)response to heat7.318e-059.088e-13Highly InformativeDirect
Biological Process (BP)hormone transport1.73e-085.955e-06Highly InformativeDirect
Biological Process (BP)glial cell differentiation0.000128.927e-07Highly InformativeDirect
Biological Process (BP)protein import2.98e-056.728e-07Highly InformativeDirect
Biological Process (BP)diencephalon development5.109e-066.196e-10Highly InformativeDirect
Biological Process (BP)lung development1.61e-150Highly InformativeDirect
Biological Process (BP)positive regulation of cell migration8.336e-058.885e-07Highly InformativeDirect
Biological Process (BP)protein localization to nucleus5e-063.278e-07Highly InformativeDirect
Biological Process (BP)limb morphogenesis3.193e-092.346e-05Highly InformativeDirect
Biological Process (BP)endocrine system development2.127e-065.841e-07Highly InformativeDirect
Biological Process (BP)amide transport2.835e-083.405e-05Highly InformativeDirect
Biological Process (BP)protein targeting to nucleus1.285e-065.12e-08Highly InformativeDirect
Biological Process (BP)cell fate commitment2.268e-113.747e-10Highly InformativeDirect
Biological Process (BP)positive regulation of lipid metabolic process7.496e-073.968e-08Highly InformativeDirect
Biological Process (BP)positive regulation of transcription, DNA-dependent1.102e-080.0003467Highly InformativeDirect
Biological Process (BP)development of primary male sexual characteristics2.976e-070.0004903Highly InformativeDirect
Biological Process (BP)inner ear development0.0001918.432e-11Highly InformativeDirect
Biological Process (BP)stem cell development0.00010645.638e-08Highly InformativeDirect
Biological Process (BP)regulation of steroid biosynthetic process00Highly InformativeDirect
Biological Process (BP)nuclear import6.721e-066.336e-08Highly InformativeDirect
Biological Process (BP)mesenchyme development3.156e-053.24e-08Highly InformativeDirect
Biological Process (BP)epithelial tube morphogenesis01.598e-05Highly InformativeDirect
Biological Process (BP)morphogenesis of a branching epithelium00Highly InformativeDirect
Biological Process (BP)cellular response to growth factor stimulus00Highly InformativeDirect
Biological Process (BP)renal system development3.76e-141.151e-12Highly InformativeDirect
Biological Process (BP)regulation of cellular response to growth factor stimulus9.542e-064.039e-07Highly InformativeDirect
Biological Process (BP)regulation of organ morphogenesis5.903e-099.374e-09Highly InformativeDirect
Biological Process (BP)embryonic organ morphogenesis0.0042342.921e-06Highly InformativeInherited
Biological Process (BP)signal release5.523e-080.05207Highly InformativeInherited
Biological Process (BP)pattern specification process0.050990.09532Highly InformativeInherited
Biological Process (BP)developmental growth1.613e-050.001497Highly InformativeInherited
Biological Process (BP)skeletal system development0.10440.002256Highly InformativeInherited
Biological Process (BP)connective tissue development0.11780.001106Highly InformativeInherited
Biological Process (BP)cell morphogenesis involved in differentiation0.11630.3318Highly InformativeInherited
Molecular Function (MF)binding2.254e-090Least InformativeDirect
Molecular Function (MF)anion binding1.853e-070.9445Moderately InformativeInherited
Molecular Function (MF)receptor binding00InformativeDirect
Molecular Function (MF)carbohydrate derivative binding3.025e-141.709e-12InformativeDirect
Molecular Function (MF)sulfur compound binding1.42e-145.085e-14InformativeDirect
Molecular Function (MF)heparin binding00Highly InformativeDirect
Molecular Function (MF)growth factor receptor binding00Highly InformativeDirect
Cellular Component (CC)cytoplasmic part0.064560.1317Least InformativeInherited
Cellular Component (CC)cytosol2.766e-053.371e-08Moderately InformativeDirect
Cellular Component (CC)extracellular region part00Moderately InformativeDirect
Cellular Component (CC)extracellular space00InformativeDirect
Cellular Component (CC)extracellular matrix2.132e-081.004e-11InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.4284 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 0.01668 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.9385 Least Informative Inherited
Biological Process (BP) reproduction 0.0008646 Moderately Informative Direct
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) signal transduction 2.618e-14 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 1.36e-06 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0 Moderately Informative Direct
Biological Process (BP) tissue development 3.262e-09 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 1.081e-08 Moderately Informative Direct
Biological Process (BP) response to organic substance 1.858e-05 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 2.78e-14 Moderately Informative Direct
Biological Process (BP) regulation of localization 1.065e-11 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 4.551e-05 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 8.799e-12 Moderately Informative Direct
Biological Process (BP) organ development 0.0003332 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 1.539e-11 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 3.746e-15 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.000922 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 3.746e-15 Moderately Informative Direct
Biological Process (BP) cellular localization 0.8106 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.7286 Moderately Informative Inherited
Biological Process (BP) regulation of programmed cell death 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.01244 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.01117 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.1445 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.1238 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.1113 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.07949 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.5711 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.01333 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.8995 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.811 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.6232 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.5366 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.2621 Moderately Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0 Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 1.652e-06 Informative Direct
Biological Process (BP) immune response 1.179e-05 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 0 Informative Direct
Biological Process (BP) cell-cell signaling 8.866e-13 Informative Direct
Biological Process (BP) steroid metabolic process 0.0004013 Informative Direct
Biological Process (BP) positive regulation of cell proliferation 0 Informative Direct
Biological Process (BP) response to wounding 5.177e-08 Informative Direct
Biological Process (BP) response to bacterium 0.0001829 Informative Direct
Biological Process (BP) positive regulation of signal transduction 1.518e-09 Informative Direct
Biological Process (BP) regulation of intracellular protein kinase cascade 4.081e-09 Informative Direct
Biological Process (BP) positive regulation of gene expression 1.333e-11 Informative Direct
Biological Process (BP) regulation of hormone levels 0.0003692 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 1.446e-08 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 4.065e-06 Informative Direct
Biological Process (BP) growth 1.092e-06 Informative Direct
Biological Process (BP) regulation of growth 0.0003781 Informative Direct
Biological Process (BP) locomotion 1.67e-13 Informative Direct
Biological Process (BP) regulation of locomotion 8.162e-13 Informative Direct
Biological Process (BP) single-organism behavior 5.616e-05 Informative Direct
Biological Process (BP) positive regulation of phosphate metabolic process 1.222e-09 Informative Direct
Biological Process (BP) embryonic organ development 0.000119 Informative Direct
Biological Process (BP) embryonic morphogenesis 4.943e-05 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 6.09e-07 Informative Direct
Biological Process (BP) tissue morphogenesis 1.055e-12 Informative Direct
Biological Process (BP) positive regulation of developmental process 3.773e-14 Informative Direct
Biological Process (BP) positive regulation of nitrogen compound metabolic process 9.702e-06 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0 Informative Direct
Biological Process (BP) positive regulation of protein metabolic process 0.0004057 Informative Direct
Biological Process (BP) regulation of cellular component movement 1.453e-13 Informative Direct
Biological Process (BP) localization of cell 1.23e-09 Informative Direct
Biological Process (BP) regulation of establishment of protein localization 0.0003473 Informative Direct
Biological Process (BP) cellular response to endogenous stimulus 1.739e-11 Informative Direct
Biological Process (BP) cardiovascular system development 9.029e-06 Informative Direct
Biological Process (BP) regulation of cell cycle 0.00529 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.9741 Informative Inherited
Biological Process (BP) cellular component movement 0.02791 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.1609 Informative Inherited
Biological Process (BP) response to hormone stimulus 1 Informative Inherited
Biological Process (BP) sensory organ development 0.002273 Informative Inherited
Biological Process (BP) epithelium development 0.05535 Informative Inherited
Biological Process (BP) gland development 0.001164 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.4101 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.001028 Informative Inherited
Biological Process (BP) reproductive structure development 0.1959 Informative Inherited
Biological Process (BP) organ morphogenesis 0.0252 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.07464 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.182 Informative Inherited
Biological Process (BP) regulation of secretion 0.2457 Informative Inherited
Biological Process (BP) positive regulation of transport 0.07972 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.6557 Informative Inherited
Biological Process (BP) response to inorganic substance 0.6601 Informative Inherited
Biological Process (BP) regulation of cell development 1 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.001571 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.008752 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.4571 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) response to organonitrogen compound 0.6194 Informative Inherited
Biological Process (BP) regulation of immune response 0.4676 Informative Inherited
Biological Process (BP) protein localization to organelle 0.1939 Informative Inherited
Biological Process (BP) regulation of nucleotide catabolic process 0.009474 Informative Inherited
Biological Process (BP) regulation of purine nucleotide metabolic process 0.001166 Informative Inherited
Biological Process (BP) regulation of nucleoside metabolic process 0.2364 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.3258 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.0287 Informative Inherited
Biological Process (BP) response to lipid 1 Informative Inherited
Biological Process (BP) central nervous system development 0.2025 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.5462 Informative Inherited
Biological Process (BP) cell activation 0.5649 Informative Inherited
Biological Process (BP) secretion by cell 0.1558 Informative Inherited
Biological Process (BP) cell death 0.03232 Informative Inherited
Biological Process (BP) protein transport 0.1661 Informative Inherited
Biological Process (BP) nitrogen compound transport 0.06717 Informative Inherited
Biological Process (BP) regulation of ion transport 0.03373 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.5791 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.2694 Informative Inherited
Biological Process (BP) MAPK cascade 0 Highly Informative Direct
Biological Process (BP) angiogenesis 3.546e-13 Highly Informative Direct
Biological Process (BP) regulation of sodium ion transport 2.026e-08 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0 Highly Informative Direct
Biological Process (BP) cell proliferation 6.075e-10 Highly Informative Direct
Biological Process (BP) response to heat 9.088e-13 Highly Informative Direct
Biological Process (BP) hormone transport 5.955e-06 Highly Informative Direct
Biological Process (BP) glial cell differentiation 8.927e-07 Highly Informative Direct
Biological Process (BP) protein import 6.728e-07 Highly Informative Direct
Biological Process (BP) diencephalon development 6.196e-10 Highly Informative Direct
Biological Process (BP) neural tube development 0.0006833 Highly Informative Direct
Biological Process (BP) lung development 0 Highly Informative Direct
Biological Process (BP) positive regulation of cell migration 8.885e-07 Highly Informative Direct
Biological Process (BP) response to lipopolysaccharide 0.0001209 Highly Informative Direct
Biological Process (BP) regulation of mononuclear cell proliferation 9.142e-15 Highly Informative Direct
Biological Process (BP) protein localization to nucleus 3.278e-07 Highly Informative Direct
Biological Process (BP) limb morphogenesis 2.346e-05 Highly Informative Direct
Biological Process (BP) endocrine system development 5.841e-07 Highly Informative Direct
Biological Process (BP) amide transport 3.405e-05 Highly Informative Direct
Biological Process (BP) positive regulation of ion transport 0.00099 Highly Informative Direct
Biological Process (BP) positive regulation of MAPK cascade 3.023e-07 Highly Informative Direct
Biological Process (BP) response to peptide hormone stimulus 1.094e-08 Highly Informative Direct
Biological Process (BP) protein targeting to nucleus 5.12e-08 Highly Informative Direct
Biological Process (BP) cell fate commitment 3.747e-10 Highly Informative Direct
Biological Process (BP) regulation of angiogenesis 0.0008094 Highly Informative Direct
Biological Process (BP) positive regulation of lipid metabolic process 3.968e-08 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-dependent 0.0003467 Highly Informative Direct
Biological Process (BP) development of primary male sexual characteristics 0.0004903 Highly Informative Direct
Biological Process (BP) regulation of nucleocytoplasmic transport 1.147e-05 Highly Informative Direct
Biological Process (BP) embryonic organ morphogenesis 2.921e-06 Highly Informative Direct
Biological Process (BP) inner ear development 8.432e-11 Highly Informative Direct
Biological Process (BP) stem cell development 5.638e-08 Highly Informative Direct
Biological Process (BP) positive regulation of epithelial cell proliferation 0.0004983 Highly Informative Direct
Biological Process (BP) regulation of steroid biosynthetic process 0 Highly Informative Direct
Biological Process (BP) positive regulation of cell activation 0.0001841 Highly Informative Direct
Biological Process (BP) neuromuscular process 0.0002276 Highly Informative Direct
Biological Process (BP) nuclear import 6.336e-08 Highly Informative Direct
Biological Process (BP) mesenchyme development 3.24e-08 Highly Informative Direct
Biological Process (BP) epithelial tube morphogenesis 1.598e-05 Highly Informative Direct
Biological Process (BP) morphogenesis of a branching epithelium 0 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 0 Highly Informative Direct
Biological Process (BP) renal system development 1.151e-12 Highly Informative Direct
Biological Process (BP) positive regulation of cell cycle process 8.7e-06 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 4.039e-07 Highly Informative Direct
Biological Process (BP) cellular response to peptide 7.015e-10 Highly Informative Direct
Biological Process (BP) regulation of organ morphogenesis 9.374e-09 Highly Informative Direct
Biological Process (BP) regulation of G1/S transition of mitotic cell cycle 1.521e-09 Highly Informative Direct
Biological Process (BP) developmental growth 0.001497 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.04512 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.2896 Highly Informative Inherited
Biological Process (BP) chemotaxis 0.3365 Highly Informative Inherited
Biological Process (BP) regulation of hormone secretion 0.1106 Highly Informative Inherited
Biological Process (BP) negative regulation of secretion 0.002337 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.0606 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.002412 Highly Informative Inherited
Biological Process (BP) regulation of mitosis 0.01473 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 0.03341 Highly Informative Inherited
Biological Process (BP) positive regulation of protein transport 0.1327 Highly Informative Inherited
Biological Process (BP) regulation of intracellular protein transport 0.004027 Highly Informative Inherited
Biological Process (BP) regulation of protein localization to nucleus 0.008009 Highly Informative Inherited
Biological Process (BP) immune response-regulating signaling pathway 0.001083 Highly Informative Inherited
Biological Process (BP) artery morphogenesis 0.1242 Highly Informative Inherited
Biological Process (BP) positive regulation of leukocyte proliferation 0.2814 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.03713 Highly Informative Inherited
Biological Process (BP) positive regulation of protein kinase activity 0.02155 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.09532 Highly Informative Inherited
Biological Process (BP) signal release 0.05207 Highly Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 0.2142 Highly Informative Inherited
Biological Process (BP) telencephalon development 0.009853 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.3167 Highly Informative Inherited
Biological Process (BP) adult behavior 0.09655 Highly Informative Inherited
Biological Process (BP) heart morphogenesis 0.02967 Highly Informative Inherited
Biological Process (BP) skeletal system development 0.002256 Highly Informative Inherited
Biological Process (BP) connective tissue development 0.001106 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 0.9985 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.3318 Highly Informative Inherited
Biological Process (BP) ossification 0.001301 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) cation binding 0.6851 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.9445 Moderately Informative Inherited
Molecular Function (MF) receptor binding 0 Informative Direct
Molecular Function (MF) transition metal ion binding 1.382e-09 Informative Direct
Molecular Function (MF) carbohydrate derivative binding 1.709e-12 Informative Direct
Molecular Function (MF) sulfur compound binding 5.085e-14 Informative Direct
Molecular Function (MF) copper ion binding 0 Highly Informative Direct
Molecular Function (MF) heparin binding 0 Highly Informative Direct
Molecular Function (MF) growth factor receptor binding 0 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0.1317 Least Informative Inherited
Cellular Component (CC) cytosol 3.371e-08 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) extracellular space 0 Informative Direct
Cellular Component (CC) cell surface 1.164e-05 Informative Direct
Cellular Component (CC) extracellular matrix 1.004e-11 Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.1017Least InformativeInherited
Disease Ontology (DO)organ system cancer0.3545Least InformativeInherited
Disease Ontology (DO)skin disease0.0003348Moderately InformativeDirect
Disease Ontology (DO)endocrine system disease0.001499Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.04762Moderately InformativeInherited
Disease Ontology (DO)hematologic cancer0.1017Moderately InformativeInherited
Disease Ontology (DO)benign neoplasm0.1212Moderately InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.1937Moderately InformativeInherited
Disease Ontology (DO)musculoskeletal system disease0.2035Moderately InformativeInherited
Disease Ontology (DO)periodontitis0.0002025InformativeDirect
Disease Ontology (DO)hemorrhagic disease0.0004508InformativeDirect
Disease Ontology (DO)malaria0.001158InformativeInherited
Disease Ontology (DO)female reproductive system disease0.001667InformativeInherited
Disease Ontology (DO)arthropathy0.009888InformativeInherited
Disease Ontology (DO)lymphoma0.01536InformativeInherited
Disease Ontology (DO)vasculitis0.0696InformativeInherited
Disease Ontology (DO)purpura2.663e-05Highly InformativeDirect
Disease Ontology (DO)spondylitis0.0003582Highly InformativeDirect
Disease Ontology (DO)Hodgkin's lymphoma0.0004909Highly InformativeDirect
Disease Ontology (DO)endometriosis0.0005325Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of head and neck0Least InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.4757Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.5Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis1Least InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.2256Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.2874Moderately InformativeInherited
Mammalian Phenotype (MP)renal/urinary system phenotype0.4595Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin secretion0.4531InformativeInherited
Mammalian Phenotype (MP)abnormal coat appearance0.9409InformativeInherited
Mammalian Phenotype (MP)abnormal ureteric bud morphology0.0007403Highly InformativeDirect
Mammalian Phenotype (MP)abnormal interleukin-1 beta secretion0.0008169Highly InformativeDirect
Mammalian Phenotype (MP)abnormal hair growth0.03235Highly InformativeInherited

Document: MP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0Least InformativeDirect
Fly Phenotype (FP)cell migration defective0Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)cell0Least InformativeDirect
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)late embryo0Moderately InformativeDirect
Fly Anatomy (FA)portion of tissue0Moderately InformativeDirect
Fly Anatomy (FA)developing material anatomical entity0Moderately InformativeDirect
Fly Anatomy (FA)extended germ band embryo0InformativeDirect
Fly Anatomy (FA)dorsal closure embryo0InformativeDirect
Fly Anatomy (FA)primordium0InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0.1227Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.2571Least InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure3.563e-07Moderately InformativeDirect
Xenopus ANatomical entity (XAN)visual system0.00298Moderately InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.003014Moderately InformativeInherited
Xenopus ANatomical entity (XAN)surface structure0.02057Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.4529Moderately InformativeInherited
Xenopus ANatomical entity (XAN)pharyngeal region5.25e-11InformativeDirect
Xenopus ANatomical entity (XAN)vestibuloauditory system2.282e-06InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm2.459e-06InformativeDirect
Xenopus ANatomical entity (XAN)notochord5.896e-05InformativeDirect
Xenopus ANatomical entity (XAN)anatomical direction7.85e-05InformativeDirect
Xenopus ANatomical entity (XAN)cranial placode0.0002814InformativeDirect
Xenopus ANatomical entity (XAN)neural plate0.009247InformativeInherited
Xenopus ANatomical entity (XAN)tail0.1954InformativeInherited
Xenopus ANatomical entity (XAN)limb0.831InformativeInherited
Xenopus ANatomical entity (XAN)cranial neural crest1.533e-07Highly InformativeDirect
Xenopus ANatomical entity (XAN)otic vesicle4.86e-06Highly InformativeDirect
Xenopus ANatomical entity (XAN)chordoneural hinge6.65e-06Highly InformativeDirect
Xenopus ANatomical entity (XAN)appendage6.659e-06Highly InformativeDirect
Xenopus ANatomical entity (XAN)limb bud1.947e-05Highly InformativeDirect
Xenopus ANatomical entity (XAN)optic vesicle2.908e-05Highly InformativeDirect
Xenopus ANatomical entity (XAN)intersomitic region0.0001185Highly InformativeDirect
Xenopus ANatomical entity (XAN)mesenchyme0.0003321Highly InformativeDirect
Xenopus ANatomical entity (XAN)lens0.0006736Highly InformativeDirect
Xenopus ANatomical entity (XAN)midbrain-hindbrain boundary0.000746Highly InformativeDirect
Xenopus ANatomical entity (XAN)involuted dorsal mesoderm0.0007633Highly InformativeDirect

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation0Moderately InformativeDirect
Biological processAngiogenesis0InformativeDirect
Biological processInflammatory response0InformativeDirect
Biological processNeurogenesis1.254e-05InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
DiseaseProto-oncogene2.821e-05Moderately InformativeDirect
DomainSignal0Least InformativeDirect
Molecular functionHeparin-binding0InformativeDirect
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationGrowth factor0InformativeDirect
Post-translational modificationCytokine0Highly InformativeDirect
Post-translational modificationMitogen0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR008996 SSF50353 Protein matches
Abstract

Human basic fibroblast growth factor (hFGF-2)1 is a globular single chain heparin-binding polypeptide synthesized by different cell types and is involved in processes associated with proliferation and differentiation of cells. The determination of the three-dimensional structure of hFGF-2 by x-ray crystallography revealed a complex all beta-sheet protein without any disulphide bond. The overall structure shows strong homology with the fold of interleukin-1 and can be described as a trigonal pyramid with three topological units consisting each of four anti-parallel beta-sheets, giving the molecules internal pseudo three-fold symmetry. Both proteins share only 10-13% sequence identity, but superposition of their carbon backbone involves 9 of the 12 beta-sheet strands, including the anti-parallel beta-sheet incorporating the N- and C-terminal regions of the molecules [PubMed10567376].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 18 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Cytokine domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 18 hidden Markov models representing the Cytokine superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]