SUPERFAMILY 1.75 HMM library and genome assignments server


Cytokine superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   beta-Trefoil [ 50352] (8)
Superfamily:   Cytokine [ 50353] (2)
Families:   Fibroblast growth factors (FGF) [ 50354] (9)
  Interleukin-1 (IL-1) [ 50362] (5)


Superfamily statistics
Genomes (144) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 2,552 3,170 61
Proteins 2,497 3,112 61


Functional annotation
General category Processes_EC
Detailed category Immune response

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process00Least InformativeDirect
Biological Process (BP)developmental process00Least InformativeDirect
Biological Process (BP)single-organism cellular process1.155e-081.949e-13Least InformativeDirect
Biological Process (BP)response to stimulus1.54e-100Least InformativeDirect
Biological Process (BP)regulation of cellular process0.62670.5388Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.14851Least InformativeInherited
Biological Process (BP)localization0.18530.02758Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.70961Least InformativeInherited
Biological Process (BP)immune system process0.00016150Moderately InformativeDirect
Biological Process (BP)signal transduction0.00018381.091e-14Moderately InformativeDirect
Biological Process (BP)anatomical structure morphogenesis3.188e-064.693e-06Moderately InformativeDirect
Biological Process (BP)response to endogenous stimulus3.321e-150Moderately InformativeDirect
Biological Process (BP)tissue development7.856e-084.457e-09Moderately InformativeDirect
Biological Process (BP)positive regulation of metabolic process2.216e-101.09e-08Moderately InformativeDirect
Biological Process (BP)response to organic substance02.11e-05Moderately InformativeDirect
Biological Process (BP)regulation of localization4.881e-052.225e-13Moderately InformativeDirect
Biological Process (BP)positive regulation of molecular function0.00012670.0004536Moderately InformativeDirect
Biological Process (BP)organ development5.786e-050.0006781Moderately InformativeDirect
Biological Process (BP)positive regulation of cellular process7.782e-063.178e-11Moderately InformativeDirect
Biological Process (BP)regulation of developmental process3.321e-150Moderately InformativeDirect
Biological Process (BP)regulation of multicellular organismal process00Moderately InformativeDirect
Biological Process (BP)cellular response to chemical stimulus2.304e-090Moderately InformativeDirect
Biological Process (BP)cellular localization0.16660.8381Moderately InformativeInherited
Biological Process (BP)regulation of biosynthetic process6.465e-100.05434Moderately InformativeInherited
Biological Process (BP)regulation of programmed cell death11Moderately InformativeInherited
Biological Process (BP)reproduction0.019890.001383Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process5.68e-070.08714Moderately InformativeInherited
Biological Process (BP)cell differentiation00.1654Moderately InformativeInherited
Biological Process (BP)regulation of catalytic activity10.098Moderately InformativeInherited
Biological Process (BP)regulation of phosphate metabolic process11.439e-14Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.94641Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.081430.1154Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.0019630.01248Moderately InformativeInherited
Biological Process (BP)positive regulation of response to stimulus0.83090.0123Moderately InformativeInherited
Biological Process (BP)organic substance transport0.00042260.01792Moderately InformativeInherited
Biological Process (BP)nervous system development10.7739Moderately InformativeInherited
Biological Process (BP)regulation of gene expression5.649e-050.9256Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.67690.6434Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.22590.000342Moderately InformativeInherited
Biological Process (BP)regulation of protein phosphorylation2.101e-130InformativeDirect
Biological Process (BP)regulation of transcription from RNA polymerase II promoter2.092e-076.994e-07InformativeDirect
Biological Process (BP)enzyme linked receptor protein signaling pathway00InformativeDirect
Biological Process (BP)positive regulation of cell proliferation00InformativeDirect
Biological Process (BP)positive regulation of gene expression3.321e-158.402e-12InformativeDirect
Biological Process (BP)regulation of lipid metabolic process2.356e-061.545e-08InformativeDirect
Biological Process (BP)regulation of anatomical structure morphogenesis9.886e-062.573e-05InformativeDirect
Biological Process (BP)positive regulation of protein modification process9.649e-157.828e-06InformativeDirect
Biological Process (BP)tube development00InformativeDirect
Biological Process (BP)growth3.751e-091.143e-05InformativeDirect
Biological Process (BP)regulation of locomotion7.638e-110InformativeDirect
Biological Process (BP)positive regulation of phosphate metabolic process9.649e-157.55e-09InformativeDirect
Biological Process (BP)anatomical structure formation involved in morphogenesis0.0003453.913e-07InformativeDirect
Biological Process (BP)tissue morphogenesis2.288e-092.802e-12InformativeDirect
Biological Process (BP)positive regulation of developmental process05.618e-15InformativeDirect
Biological Process (BP)positive regulation of nitrogen compound metabolic process1.107e-107.452e-06InformativeDirect
Biological Process (BP)positive regulation of multicellular organismal process1.173e-090InformativeDirect
Biological Process (BP)regulation of cellular component movement1.661e-110InformativeDirect
Biological Process (BP)cellular response to endogenous stimulus4.735e-075.012e-13InformativeDirect
Biological Process (BP)cardiovascular system development0.00020842.655e-06InformativeDirect
Biological Process (BP)sensory organ development0.038410.003121InformativeInherited
Biological Process (BP)epithelium development0.015520.04324InformativeInherited
Biological Process (BP)gland development0.0028560.001122InformativeInherited
Biological Process (BP)central nervous system development0.22110.2246InformativeInherited
Biological Process (BP)cytoplasmic transport0.0035240.00131InformativeInherited
Biological Process (BP)regulation of cell development0.69741InformativeInherited
Biological Process (BP)regulation of growth0.071090.0004117InformativeInherited
Biological Process (BP)developmental process involved in reproduction0.96640.6946InformativeInherited
Biological Process (BP)positive regulation of macromolecule biosynthetic process6.957e-100.001371InformativeInherited
Biological Process (BP)positive regulation of cellular biosynthetic process3.115e-090.00763InformativeInherited
Biological Process (BP)protein localization to organelle0.00084370.1702InformativeInherited
Biological Process (BP)regulation of kinase activity0.74570.344InformativeInherited
Biological Process (BP)regulation of cytokine production0.66930.03151InformativeInherited
Biological Process (BP)organ morphogenesis0.18350.03905InformativeInherited
Biological Process (BP)embryonic organ development0.028280.0001695InformativeInherited
Biological Process (BP)embryonic morphogenesis0.067797.448e-05InformativeInherited
Biological Process (BP)positive regulation of signal transduction0.002311.882e-09InformativeInherited
Biological Process (BP)secretion by cell0.0056440.154InformativeInherited
Biological Process (BP)regulation of hormone levels2.018e-060.001035InformativeInherited
Biological Process (BP)protein transport0.37890.1628InformativeInherited
Biological Process (BP)nitrogen compound transport0.0044080.07668InformativeInherited
Biological Process (BP)cellular component morphogenesis0.48170.6302InformativeInherited
Biological Process (BP)intracellular signal transduction10.2502InformativeInherited
Biological Process (BP)MAPK cascade0.00087170Highly InformativeDirect
Biological Process (BP)angiogenesis6.439e-074.463e-14Highly InformativeDirect
Biological Process (BP)transmembrane receptor protein tyrosine kinase signaling pathway00Highly InformativeDirect
Biological Process (BP)response to heat0.00013931.377e-12Highly InformativeDirect
Biological Process (BP)hormone transport6.906e-096.235e-06Highly InformativeDirect
Biological Process (BP)glial cell differentiation9.425e-052.152e-06Highly InformativeDirect
Biological Process (BP)protein import2.868e-057.949e-07Highly InformativeDirect
Biological Process (BP)diencephalon development4.216e-065.152e-10Highly InformativeDirect
Biological Process (BP)respiratory tube development4.957e-150Highly InformativeDirect
Biological Process (BP)positive regulation of cell migration6.979e-053.544e-05Highly InformativeDirect
Biological Process (BP)protein localization to nucleus5.858e-063.753e-07Highly InformativeDirect
Biological Process (BP)limb morphogenesis4.844e-097.617e-06Highly InformativeDirect
Biological Process (BP)endocrine system development1.577e-064.343e-07Highly InformativeDirect
Biological Process (BP)amide transport2.644e-085.249e-05Highly InformativeDirect
Biological Process (BP)protein targeting to nucleus1.514e-065.766e-08Highly InformativeDirect
Biological Process (BP)cell fate commitment1.002e-112.644e-10Highly InformativeDirect
Biological Process (BP)positive regulation of lipid metabolic process5.58e-072.382e-08Highly InformativeDirect
Biological Process (BP)positive regulation of transcription, DNA-dependent2.725e-090.0002736Highly InformativeDirect
Biological Process (BP)branching morphogenesis of an epithelial tube01.66e-10Highly InformativeDirect
Biological Process (BP)stem cell development9.858e-051.421e-07Highly InformativeDirect
Biological Process (BP)regulation of steroid biosynthetic process00Highly InformativeDirect
Biological Process (BP)nuclear import6.306e-067.133e-08Highly InformativeDirect
Biological Process (BP)regulation of cell division1.974e-128.305e-07Highly InformativeDirect
Biological Process (BP)mesenchyme development2.613e-053.735e-08Highly InformativeDirect
Biological Process (BP)respiratory system development1.366e-120Highly InformativeDirect
Biological Process (BP)cellular response to growth factor stimulus00Highly InformativeDirect
Biological Process (BP)renal system development3.691e-141.305e-12Highly InformativeDirect
Biological Process (BP)regulation of cellular response to growth factor stimulus1.008e-053.809e-07Highly InformativeDirect
Biological Process (BP)regulation of organ morphogenesis1.062e-083.926e-08Highly InformativeDirect
Biological Process (BP)regulation of striated muscle tissue development14.412e-13Highly InformativeInherited
Biological Process (BP)regulation of developmental growth0.27640.02855Highly InformativeInherited
Biological Process (BP)regulation of transmembrane receptor protein serine/threonine kinase signaling pathway0.0018920.0447Highly InformativeInherited
Biological Process (BP)ear development0.003573.672e-09Highly InformativeInherited
Biological Process (BP)embryonic organ morphogenesis0.0046912.488e-06Highly InformativeInherited
Biological Process (BP)signal release7.242e-080.05641Highly InformativeInherited
Biological Process (BP)pattern specification process0.055040.1276Highly InformativeInherited
Biological Process (BP)developmental growth1.304e-050.001863Highly InformativeInherited
Biological Process (BP)skeletal system development0.097750.002591Highly InformativeInherited
Biological Process (BP)connective tissue development0.11810.001395Highly InformativeInherited
Molecular Function (MF)binding4.543e-090Least InformativeDirect
Molecular Function (MF)anion binding4.752e-080.8926Moderately InformativeInherited
Molecular Function (MF)receptor binding00InformativeDirect
Molecular Function (MF)carbohydrate derivative binding5.07e-141.766e-12InformativeDirect
Molecular Function (MF)sulfur compound binding04.58e-15InformativeDirect
Molecular Function (MF)heparin binding1.448e-140Highly InformativeDirect
Molecular Function (MF)growth factor receptor binding00Highly InformativeDirect
Cellular Component (CC)cytoplasmic part0.14870.2487Least InformativeInherited
Cellular Component (CC)cytosol7.068e-051.251e-07Moderately InformativeDirect
Cellular Component (CC)extracellular region part00Moderately InformativeDirect
Cellular Component (CC)extracellular space00InformativeDirect
Cellular Component (CC)extracellular matrix2.91e-082.521e-11InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 1.949e-13 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.5388 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 0.02758 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) signal transduction 1.091e-14 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 4.693e-06 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0 Moderately Informative Direct
Biological Process (BP) tissue development 4.457e-09 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 1.09e-08 Moderately Informative Direct
Biological Process (BP) response to organic substance 2.11e-05 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 1.439e-14 Moderately Informative Direct
Biological Process (BP) regulation of localization 2.225e-13 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 0.0004536 Moderately Informative Direct
Biological Process (BP) organ development 0.0006781 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 3.178e-11 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.000342 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.6662 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.8381 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 0.05434 Moderately Informative Inherited
Biological Process (BP) regulation of programmed cell death 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.001383 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.0123 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.01248 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.1654 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.098 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.1154 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.08714 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.494 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.01792 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.9256 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.7739 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.6434 Moderately Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0 Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 6.994e-07 Informative Direct
Biological Process (BP) apoptotic process 6.341e-08 Informative Direct
Biological Process (BP) immune response 6.201e-06 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 0 Informative Direct
Biological Process (BP) positive regulation of cell proliferation 0 Informative Direct
Biological Process (BP) response to wounding 6.71e-08 Informative Direct
Biological Process (BP) positive regulation of signal transduction 1.882e-09 Informative Direct
Biological Process (BP) regulation of intracellular protein kinase cascade 4.354e-09 Informative Direct
Biological Process (BP) positive regulation of gene expression 8.402e-12 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 1.545e-08 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 2.573e-05 Informative Direct
Biological Process (BP) positive regulation of protein modification process 7.828e-06 Informative Direct
Biological Process (BP) tube development 0 Informative Direct
Biological Process (BP) growth 1.143e-05 Informative Direct
Biological Process (BP) regulation of growth 0.0004117 Informative Direct
Biological Process (BP) locomotion 6.11e-13 Informative Direct
Biological Process (BP) regulation of locomotion 0 Informative Direct
Biological Process (BP) single-organism behavior 0.0001081 Informative Direct
Biological Process (BP) positive regulation of phosphate metabolic process 7.55e-09 Informative Direct
Biological Process (BP) embryonic organ development 0.0001695 Informative Direct
Biological Process (BP) embryonic morphogenesis 7.448e-05 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 3.913e-07 Informative Direct
Biological Process (BP) tissue morphogenesis 2.802e-12 Informative Direct
Biological Process (BP) positive regulation of developmental process 5.618e-15 Informative Direct
Biological Process (BP) positive regulation of nitrogen compound metabolic process 7.452e-06 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0 Informative Direct
Biological Process (BP) regulation of cellular component movement 0 Informative Direct
Biological Process (BP) localization of cell 1.555e-09 Informative Direct
Biological Process (BP) negative regulation of cell death 0.0005404 Informative Direct
Biological Process (BP) regulation of establishment of protein localization 0.0005743 Informative Direct
Biological Process (BP) cellular response to endogenous stimulus 5.012e-13 Informative Direct
Biological Process (BP) cardiovascular system development 2.655e-06 Informative Direct
Biological Process (BP) regulation of cell cycle process 0.2455 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.8982 Informative Inherited
Biological Process (BP) cellular component movement 0.03373 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.1085 Informative Inherited
Biological Process (BP) response to hormone stimulus 1 Informative Inherited
Biological Process (BP) sensory organ development 0.003121 Informative Inherited
Biological Process (BP) epithelium development 0.04324 Informative Inherited
Biological Process (BP) gland development 0.001122 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.3769 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.00131 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.6946 Informative Inherited
Biological Process (BP) reproductive system development 0.3907 Informative Inherited
Biological Process (BP) organ morphogenesis 0.03905 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.1394 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.2502 Informative Inherited
Biological Process (BP) regulation of secretion 0.2405 Informative Inherited
Biological Process (BP) negative regulation of transport 0.07832 Informative Inherited
Biological Process (BP) positive regulation of transport 0.09642 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.6191 Informative Inherited
Biological Process (BP) response to inorganic substance 0.6466 Informative Inherited
Biological Process (BP) regulation of cell development 1 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.001371 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.00763 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.478 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) response to organonitrogen compound 0.628 Informative Inherited
Biological Process (BP) regulation of immune response 0.4274 Informative Inherited
Biological Process (BP) protein localization to organelle 0.1702 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 0.4871 Informative Inherited
Biological Process (BP) regulation of purine nucleotide metabolic process 0.001471 Informative Inherited
Biological Process (BP) regulation of nucleoside metabolic process 0.2241 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.8212 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.03151 Informative Inherited
Biological Process (BP) response to lipid 1 Informative Inherited
Biological Process (BP) response to other organism 0.008871 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.001412 Informative Inherited
Biological Process (BP) central nervous system development 0.2246 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.4768 Informative Inherited
Biological Process (BP) leukocyte activation 1 Informative Inherited
Biological Process (BP) secretion by cell 0.154 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.001035 Informative Inherited
Biological Process (BP) protein transport 0.1628 Informative Inherited
Biological Process (BP) nitrogen compound transport 0.07668 Informative Inherited
Biological Process (BP) regulation of ion transport 0.03857 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.6302 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.344 Informative Inherited
Biological Process (BP) MAPK cascade 0 Highly Informative Direct
Biological Process (BP) angiogenesis 4.463e-14 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0 Highly Informative Direct
Biological Process (BP) response to heat 1.377e-12 Highly Informative Direct
Biological Process (BP) hormone transport 6.235e-06 Highly Informative Direct
Biological Process (BP) glial cell differentiation 2.152e-06 Highly Informative Direct
Biological Process (BP) regulation of striated muscle tissue development 4.412e-13 Highly Informative Direct
Biological Process (BP) protein import 7.949e-07 Highly Informative Direct
Biological Process (BP) diencephalon development 5.152e-10 Highly Informative Direct
Biological Process (BP) neural tube development 0.0007431 Highly Informative Direct
Biological Process (BP) respiratory tube development 0 Highly Informative Direct
Biological Process (BP) positive regulation of cell migration 3.544e-05 Highly Informative Direct
Biological Process (BP) response to lipopolysaccharide 0.0001391 Highly Informative Direct
Biological Process (BP) regulation of mononuclear cell proliferation 1.958e-14 Highly Informative Direct
Biological Process (BP) protein localization to nucleus 3.753e-07 Highly Informative Direct
Biological Process (BP) limb morphogenesis 7.617e-06 Highly Informative Direct
Biological Process (BP) endocrine system development 4.343e-07 Highly Informative Direct
Biological Process (BP) amide transport 5.249e-05 Highly Informative Direct
Biological Process (BP) positive regulation of ion transport 0.000919 Highly Informative Direct
Biological Process (BP) positive regulation of MAPK cascade 4.719e-07 Highly Informative Direct
Biological Process (BP) response to peptide hormone stimulus 7.113e-09 Highly Informative Direct
Biological Process (BP) ear development 3.672e-09 Highly Informative Direct
Biological Process (BP) protein targeting to nucleus 5.766e-08 Highly Informative Direct
Biological Process (BP) cell fate commitment 2.644e-10 Highly Informative Direct
Biological Process (BP) regulation of angiogenesis 0.000772 Highly Informative Direct
Biological Process (BP) positive regulation of lipid metabolic process 2.382e-08 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-dependent 0.0002736 Highly Informative Direct
Biological Process (BP) regulation of nucleocytoplasmic transport 1.383e-05 Highly Informative Direct
Biological Process (BP) embryonic organ morphogenesis 2.488e-06 Highly Informative Direct
Biological Process (BP) branching morphogenesis of an epithelial tube 1.66e-10 Highly Informative Direct
Biological Process (BP) stem cell development 1.421e-07 Highly Informative Direct
Biological Process (BP) positive regulation of epithelial cell proliferation 0.0002789 Highly Informative Direct
Biological Process (BP) regulation of steroid biosynthetic process 0 Highly Informative Direct
Biological Process (BP) positive regulation of cell activation 0.0001449 Highly Informative Direct
Biological Process (BP) neuromuscular process 0.0002731 Highly Informative Direct
Biological Process (BP) nuclear import 7.133e-08 Highly Informative Direct
Biological Process (BP) regulation of cell division 8.305e-07 Highly Informative Direct
Biological Process (BP) mesenchyme development 3.735e-08 Highly Informative Direct
Biological Process (BP) respiratory system development 0 Highly Informative Direct
Biological Process (BP) neural precursor cell proliferation 0.0007768 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 0 Highly Informative Direct
Biological Process (BP) renal system development 1.305e-12 Highly Informative Direct
Biological Process (BP) positive regulation of cell cycle process 7.86e-06 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 3.809e-07 Highly Informative Direct
Biological Process (BP) cellular response to peptide 2.419e-09 Highly Informative Direct
Biological Process (BP) regulation of organ morphogenesis 3.926e-08 Highly Informative Direct
Biological Process (BP) regulation of G1/S transition of mitotic cell cycle 3.032e-09 Highly Informative Direct
Biological Process (BP) developmental growth 0.001863 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.02855 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.2939 Highly Informative Inherited
Biological Process (BP) chemotaxis 0.3286 Highly Informative Inherited
Biological Process (BP) regulation of hormone secretion 0.115 Highly Informative Inherited
Biological Process (BP) negative regulation of secretion 0.00206 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.05792 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.002814 Highly Informative Inherited
Biological Process (BP) regulation of mitosis 0.01486 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 0.0301 Highly Informative Inherited
Biological Process (BP) regulation of intracellular protein transport 0.003488 Highly Informative Inherited
Biological Process (BP) regulation of protein localization to nucleus 0.007981 Highly Informative Inherited
Biological Process (BP) immune response-regulating cell surface receptor signaling pathway 0.005565 Highly Informative Inherited
Biological Process (BP) artery morphogenesis 0.1467 Highly Informative Inherited
Biological Process (BP) positive regulation of leukocyte proliferation 0.2967 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.0447 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.05646 Highly Informative Inherited
Biological Process (BP) positive regulation of protein kinase activity 0.02111 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.1276 Highly Informative Inherited
Biological Process (BP) signal release 0.05641 Highly Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 0.2297 Highly Informative Inherited
Biological Process (BP) telencephalon development 0.01198 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.2995 Highly Informative Inherited
Biological Process (BP) adult behavior 0.1096 Highly Informative Inherited
Biological Process (BP) heart morphogenesis 0.03816 Highly Informative Inherited
Biological Process (BP) skeletal system development 0.002591 Highly Informative Inherited
Biological Process (BP) connective tissue development 0.001395 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 0.9995 Highly Informative Inherited
Biological Process (BP) ossification 0.002316 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) cation binding 0.7644 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.8926 Moderately Informative Inherited
Molecular Function (MF) receptor binding 0 Informative Direct
Molecular Function (MF) transition metal ion binding 2.156e-09 Informative Direct
Molecular Function (MF) carbohydrate derivative binding 1.766e-12 Informative Direct
Molecular Function (MF) sulfur compound binding 4.58e-15 Informative Direct
Molecular Function (MF) copper ion binding 0 Highly Informative Direct
Molecular Function (MF) heparin binding 0 Highly Informative Direct
Molecular Function (MF) growth factor receptor binding 0 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0.2487 Least Informative Inherited
Cellular Component (CC) cytosol 1.251e-07 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) extracellular space 0 Informative Direct
Cellular Component (CC) cell surface 2.796e-05 Informative Direct
Cellular Component (CC) extracellular matrix 2.521e-11 Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.1119Least InformativeInherited
Disease Ontology (DO)organ system cancer0.3559Least InformativeInherited
Disease Ontology (DO)skin disease0.0003434Moderately InformativeDirect
Disease Ontology (DO)endocrine system disease0.001686Moderately InformativeInherited
Disease Ontology (DO)bone disease0.01707Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.05037Moderately InformativeInherited
Disease Ontology (DO)hematologic cancer0.102Moderately InformativeInherited
Disease Ontology (DO)benign neoplasm0.1226Moderately InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.1954Moderately InformativeInherited
Disease Ontology (DO)periodontitis0.0001988InformativeDirect
Disease Ontology (DO)hemorrhagic disease0.0004482InformativeDirect
Disease Ontology (DO)malaria0.001137InformativeInherited
Disease Ontology (DO)female reproductive system disease0.001672InformativeInherited
Disease Ontology (DO)arthropathy0.01015InformativeInherited
Disease Ontology (DO)lymphoma0.01587InformativeInherited
Disease Ontology (DO)vasculitis0.06771InformativeInherited
Disease Ontology (DO)cell type benign neoplasm0.09265InformativeInherited
Disease Ontology (DO)purpura2.743e-05Highly InformativeDirect
Disease Ontology (DO)spondylitis0.0003643Highly InformativeDirect
Disease Ontology (DO)Hodgkin's lymphoma0.0004994Highly InformativeDirect
Disease Ontology (DO)endometriosis0.0005245Highly InformativeDirect
Disease Ontology (DO)Behcet's disease0.0006127Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of head and neck0Least InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.4731Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.5464Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis1Least InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.05484Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.196Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.2885Moderately InformativeInherited
Mammalian Phenotype (MP)renal/urinary system phenotype0.4598Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin secretion0.4588InformativeInherited
Mammalian Phenotype (MP)abnormal coat appearance0.9417InformativeInherited
Mammalian Phenotype (MP)abnormal ureteric bud morphology0.0006988Highly InformativeDirect
Mammalian Phenotype (MP)abnormal interleukin-1 beta secretion0.0008605Highly InformativeDirect
Mammalian Phenotype (MP)abnormal hair growth0.03144Highly InformativeInherited
Mammalian Phenotype (MP)abnormal skin physiology0.05737Highly InformativeInherited

Document: MP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0Least InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)cell0Least InformativeDirect
Fly Anatomy (FA)late embryo0Moderately InformativeDirect
Fly Anatomy (FA)developing material anatomical entity0Moderately InformativeDirect
Fly Anatomy (FA)extended germ band embryo0InformativeDirect
Fly Anatomy (FA)dorsal closure embryo0InformativeDirect
Fly Anatomy (FA)primordium0InformativeDirect
Fly Anatomy (FA)glial cell0Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)multi-tissue structure0Least InformativeDirect
Zebrafish Anatomy (ZA)nervous system0.1125Least InformativeInherited
Zebrafish Anatomy (ZA)surface structure0Moderately InformativeDirect
Zebrafish Anatomy (ZA)peripheral nervous system0.0003393InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0.1246Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.2568Least InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure4.548e-07Moderately InformativeDirect
Xenopus ANatomical entity (XAN)visual system0.003114Moderately InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.003363Moderately InformativeInherited
Xenopus ANatomical entity (XAN)surface structure0.02092Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.4557Moderately InformativeInherited
Xenopus ANatomical entity (XAN)pharyngeal region1.022e-10InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm3.387e-06InformativeDirect
Xenopus ANatomical entity (XAN)vestibuloauditory system3.532e-06InformativeDirect
Xenopus ANatomical entity (XAN)cranial placode2.749e-05InformativeDirect
Xenopus ANatomical entity (XAN)notochord6.366e-05InformativeDirect
Xenopus ANatomical entity (XAN)anatomical direction0.000105InformativeDirect
Xenopus ANatomical entity (XAN)mesenchyme0.0004344InformativeDirect
Xenopus ANatomical entity (XAN)neural plate0.01171InformativeInherited
Xenopus ANatomical entity (XAN)primordium0.0166InformativeInherited
Xenopus ANatomical entity (XAN)tail0.1965InformativeInherited
Xenopus ANatomical entity (XAN)limb0.8312InformativeInherited
Xenopus ANatomical entity (XAN)cranial neural crest2.505e-07Highly InformativeDirect
Xenopus ANatomical entity (XAN)chordoneural hinge6.64e-06Highly InformativeDirect
Xenopus ANatomical entity (XAN)appendage6.656e-06Highly InformativeDirect
Xenopus ANatomical entity (XAN)limb bud2.187e-05Highly InformativeDirect
Xenopus ANatomical entity (XAN)optic vesicle5.33e-05Highly InformativeDirect
Xenopus ANatomical entity (XAN)intersomitic region0.0001621Highly InformativeDirect
Xenopus ANatomical entity (XAN)stomodeal-hypophyseal primordium0.000534Highly InformativeDirect
Xenopus ANatomical entity (XAN)lens0.0008654Highly InformativeDirect
Xenopus ANatomical entity (XAN)midbrain-hindbrain boundary0.000903Highly InformativeDirect
Xenopus ANatomical entity (XAN)involuted dorsal mesoderm0.0009735Highly InformativeDirect

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation0Moderately InformativeDirect
Biological processAngiogenesis0InformativeDirect
Biological processInflammatory response0InformativeDirect
Biological processNeurogenesis1.326e-05InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
DiseaseProto-oncogene2.518e-05Moderately InformativeDirect
DomainSignal0Least InformativeDirect
Molecular functionHeparin-binding0InformativeDirect
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationGrowth factor0InformativeDirect
Post-translational modificationCytokine0Highly InformativeDirect
Post-translational modificationMitogen0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR008996 SSF50353 Protein matches
Abstract

Human basic fibroblast growth factor (hFGF-2)1 is a globular single chain heparin-binding polypeptide synthesized by different cell types and is involved in processes associated with proliferation and differentiation of cells. The determination of the three-dimensional structure of hFGF-2 by x-ray crystallography revealed a complex all beta-sheet protein without any disulphide bond. The overall structure shows strong homology with the fold of interleukin-1 and can be described as a trigonal pyramid with three topological units consisting each of four anti-parallel beta-sheets, giving the molecules internal pseudo three-fold symmetry. Both proteins share only 10-13% sequence identity, but superposition of their carbon backbone involves 9 of the 12 beta-sheet strands, including the anti-parallel beta-sheet incorporating the N- and C-terminal regions of the molecules [PubMed10567376].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 18 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Cytokine domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 18 hidden Markov models representing the Cytokine superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]