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Cytokine superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   beta-Trefoil [ 50352] (8)
Superfamily:   Cytokine [ 50353] (2)
Families:   Fibroblast growth factors (FGF) [ 50354] (9)
  Interleukin-1 (IL-1) [ 50362] (5)


Superfamily statistics
Genomes (147) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 2,542 5,601 61
Proteins 2,487 5,505 61


Functional annotation
General category Processes_EC
Detailed category Immune response

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process00Least InformativeDirect
Biological Process (BP)response to stimulus0.000000016280Least InformativeDirect
Biological Process (BP)biological regulation00Least InformativeDirect
Biological Process (BP)single-organism cellular process10.001736Least InformativeInherited
Biological Process (BP)immune system process0.0000082220Moderately InformativeDirect
Biological Process (BP)cell communication0.00000000000032370Moderately InformativeDirect
Biological Process (BP)anatomical structure morphogenesis0.0000001880.00000519Moderately InformativeDirect
Biological Process (BP)response to endogenous stimulus0.000000000018980Moderately InformativeDirect
Biological Process (BP)tissue development0.0000000040270.000000002006Moderately InformativeDirect
Biological Process (BP)positive regulation of metabolic process0.00035830.0004894Moderately InformativeDirect
Biological Process (BP)regulation of cell communication0.00013760.0000000008663Moderately InformativeDirect
Biological Process (BP)regulation of signaling0.00015390.000000001063Moderately InformativeDirect
Biological Process (BP)regulation of localization0.0002450Moderately InformativeDirect
Biological Process (BP)single organism signaling0.0000000059040Moderately InformativeDirect
Biological Process (BP)animal organ development0.000000055160.0000006407Moderately InformativeDirect
Biological Process (BP)regulation of developmental process0.000000000029960.000000007794Moderately InformativeDirect
Biological Process (BP)regulation of multicellular organismal process00Moderately InformativeDirect
Biological Process (BP)cellular response to chemical stimulus0.000013090.000000005198Moderately InformativeDirect
Biological Process (BP)regulation of macromolecule biosynthetic process0.049041Moderately InformativeInherited
Biological Process (BP)cell differentiation0.0000034330.2797Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.031670.000002919Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.11481Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.021651Moderately InformativeInherited
Biological Process (BP)response to organic substance0.00000000000021040.006879Moderately InformativeInherited
Biological Process (BP)regulation of molecular function0.12180.02157Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.38140.5726Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.4320.9405Moderately InformativeInherited
Biological Process (BP)regulation of response to stimulus0.0036420.000001551Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process0.10471Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.016730.0000000001632Moderately InformativeInherited
Biological Process (BP)cell activation0.00016130.000000000589InformativeDirect
Biological Process (BP)regulation of transcription from RNA polymerase II promoter00.0009878InformativeDirect
Biological Process (BP)cell surface receptor signaling pathway0.00000034580.00000000008388InformativeDirect
Biological Process (BP)response to temperature stimulus0.00000017650InformativeDirect
Biological Process (BP)animal organ morphogenesis00.00001145InformativeDirect
Biological Process (BP)positive regulation of signal transduction0.0000079060.000001036InformativeDirect
Biological Process (BP)positive regulation of gene expression0.0000020270.0001041InformativeDirect
Biological Process (BP)regulation of lipid metabolic process0.0000000045230.0000000006645InformativeDirect
Biological Process (BP)regulation of anatomical structure morphogenesis0.0000000012110.0000005064InformativeDirect
Biological Process (BP)positive regulation of cellular protein metabolic process0.00032840.00000000001215InformativeDirect
Biological Process (BP)growth0.0000000000005110.0000007506InformativeDirect
Biological Process (BP)regulation of locomotion0.00000001890InformativeDirect
Biological Process (BP)regulation of cell proliferation0.0000000000024670InformativeDirect
Biological Process (BP)regulation of phosphorylation0.0000000000035280InformativeDirect
Biological Process (BP)positive regulation of catalytic activity0.00000000031380.0009573InformativeDirect
Biological Process (BP)positive regulation of nucleobase-containing compound metabolic process0.000035980.0007365InformativeDirect
Biological Process (BP)positive regulation of phosphate metabolic process0.00000000000025050.00003408InformativeDirect
Biological Process (BP)regulation of secretion0.0000640.0000635InformativeDirect
Biological Process (BP)positive regulation of developmental process0.00000000002120.0000003592InformativeDirect
Biological Process (BP)positive regulation of multicellular organismal process0.000000000000006150InformativeDirect
Biological Process (BP)regulation of cellular component movement0.0000000044770InformativeDirect
Biological Process (BP)regulation of transferase activity0.0000000000021630.00000001903InformativeDirect
Biological Process (BP)positive regulation of macromolecule biosynthetic process0.000026430.03892InformativeInherited
Biological Process (BP)positive regulation of transport0.94460.004105InformativeInherited
Biological Process (BP)regulation of protein localization11InformativeInherited
Biological Process (BP)epithelium development0.0014520.2854InformativeInherited
Biological Process (BP)positive regulation of immune system process0.95170.0000007911InformativeInherited
Biological Process (BP)regulation of peptide transport0.032120.1494InformativeInherited
Biological Process (BP)positive regulation of cellular biosynthetic process0.00013620.109InformativeInherited
Biological Process (BP)regulation of intracellular signal transduction0.0031040.00000002103InformativeInherited
Biological Process (BP)regulation of cell differentiation0.2030.0261InformativeInherited
Biological Process (BP)embryo development0.27190.4006InformativeInherited
Biological Process (BP)regulation of cytokine production0.53520.001379InformativeInherited
Biological Process (BP)regulation of protein modification process0.011740.000000965InformativeInherited
Biological Process (BP)anatomical structure formation involved in morphogenesis0.014090.004027InformativeInherited
Biological Process (BP)kidney development00.00000000000002436Highly InformativeDirect
Biological Process (BP)enzyme linked receptor protein signaling pathway0.0000000000057130.00000000001672Highly InformativeDirect
Biological Process (BP)cell-cell signaling0.00056560Highly InformativeDirect
Biological Process (BP)cell proliferation0.0000057420Highly InformativeDirect
Biological Process (BP)response to heat0.000010520.000000000002679Highly InformativeDirect
Biological Process (BP)regulation of epithelial cell migration0.000064180.00000000061Highly InformativeDirect
Biological Process (BP)positive regulation of cell migration0.00017510.0001525Highly InformativeDirect
Biological Process (BP)tube morphogenesis00.000000000000114Highly InformativeDirect
Biological Process (BP)regulation of MAP kinase activity0.000040150.0003137Highly InformativeDirect
Biological Process (BP)positive regulation of MAPK cascade0.00065980.0000005325Highly InformativeDirect
Biological Process (BP)positive regulation of angiogenesis0.0003030.0000003326Highly InformativeDirect
Biological Process (BP)positive regulation of lipid metabolic process0.00000000073660.000000001839Highly InformativeDirect
Biological Process (BP)positive regulation of transcription from RNA polymerase II promoter00.0008013Highly InformativeDirect
Biological Process (BP)regulation of lymphocyte proliferation0.000078290.0000001737Highly InformativeDirect
Biological Process (BP)regulation of steroid biosynthetic process00Highly InformativeDirect
Biological Process (BP)positive regulation of lymphocyte activation0.000056270Highly InformativeDirect
Biological Process (BP)regulation of cell division0.00000000000024920.0000004425Highly InformativeDirect
Biological Process (BP)response to growth factor00Highly InformativeDirect
Biological Process (BP)positive regulation of protein serine/threonine kinase activity00.00002826Highly InformativeDirect
Biological Process (BP)regulation of cytokine secretion0.027250.000007507Highly InformativeInherited
Biological Process (BP)positive regulation of cytokine production0.95060.0007645Highly InformativeInherited
Biological Process (BP)positive regulation of peptide secretion0.044560.00167Highly InformativeInherited
Biological Process (BP)positive regulation of protein transport0.017080.0009764Highly InformativeInherited
Biological Process (BP)positive regulation of secretion by cell0.25710.0005243Highly InformativeInherited
Biological Process (BP)morphogenesis of an epithelium0.026960.0003119Highly InformativeInherited
Biological Process (BP)epithelial cell differentiation0.36420.8666Highly InformativeInherited
Biological Process (BP)appendage development0.01020.0001641Highly InformativeInherited
Biological Process (BP)lymphocyte activation0.000000056550.0518Highly InformativeInherited
Biological Process (BP)positive regulation of leukocyte proliferation0.77410.000002624Highly InformativeInherited
Biological Process (BP)activation of protein kinase activity0.11180.001167Highly InformativeInherited
Biological Process (BP)developmental growth involved in morphogenesis0.000042490.00132Highly InformativeInherited
Biological Process (BP)gastrulation0.37450.8613Highly InformativeInherited
Molecular Function (MF)binding0.00000039080.000000000000168Least InformativeDirect
Molecular Function (MF)carbohydrate derivative binding0.000000000010660.0000001619Moderately InformativeDirect
Molecular Function (MF)anion binding0.00000000000023390.5359Moderately InformativeInherited
Molecular Function (MF)receptor binding00InformativeDirect
Molecular Function (MF)sulfur compound binding00InformativeDirect
Molecular Function (MF)macromolecular complex binding0.000000000027570.004374InformativeInherited
Molecular Function (MF)heparin binding00Highly InformativeDirect
Molecular Function (MF)cell adhesion molecule binding00.0000007001Highly InformativeDirect
Molecular Function (MF)cytokine receptor binding11Highly InformativeInherited
Cellular Component (CC)extracellular region part00Moderately InformativeDirect
Cellular Component (CC)extracellular space00InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.001736 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 0.3416 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 0.1876 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.00001392 Moderately Informative Direct
Biological Process (BP) cell communication 0 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.00000519 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0 Moderately Informative Direct
Biological Process (BP) tissue development 0.000000002006 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0.0004894 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 0.0000000008663 Moderately Informative Direct
Biological Process (BP) regulation of signaling 0.000000001063 Moderately Informative Direct
Biological Process (BP) regulation of localization 0 Moderately Informative Direct
Biological Process (BP) single organism signaling 0 Moderately Informative Direct
Biological Process (BP) animal organ development 0.0000006407 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.000002919 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0.000001551 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.000000007794 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.0000000001632 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.000000005198 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.2797 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.006879 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.02157 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.4912 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.1648 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.5726 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.9405 Moderately Informative Inherited
Biological Process (BP) response to biotic stimulus 0.6197 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.6055 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.1173 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.06625 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) defense response 0.01667 Moderately Informative Inherited
Biological Process (BP) cell activation 0.000000000589 Informative Direct
Biological Process (BP) positive regulation of immune system process 0.0000007911 Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.0009878 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0.0005393 Informative Direct
Biological Process (BP) cell surface receptor signaling pathway 0.00000000008388 Informative Direct
Biological Process (BP) response to temperature stimulus 0 Informative Direct
Biological Process (BP) response to wounding 0.0003046 Informative Direct
Biological Process (BP) response to bacterium 0.0002817 Informative Direct
Biological Process (BP) animal organ morphogenesis 0.00001145 Informative Direct
Biological Process (BP) positive regulation of signal transduction 0.000001036 Informative Direct
Biological Process (BP) positive regulation of gene expression 0.0001041 Informative Direct
Biological Process (BP) regulation of hormone levels 0.0001202 Informative Direct
Biological Process (BP) lipid localization 0.00002331 Informative Direct
Biological Process (BP) phosphorylation 0.0000004201 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 0.0000000006645 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.0000005064 Informative Direct
Biological Process (BP) regulation of protein modification process 0.000000965 Informative Direct
Biological Process (BP) positive regulation of cellular protein metabolic process 0.00000000001215 Informative Direct
Biological Process (BP) growth 0.0000007506 Informative Direct
Biological Process (BP) locomotion 0.00000000000007943 Informative Direct
Biological Process (BP) regulation of locomotion 0 Informative Direct
Biological Process (BP) regulation of cell proliferation 0 Informative Direct
Biological Process (BP) regulation of phosphorylation 0 Informative Direct
Biological Process (BP) positive regulation of catalytic activity 0.0009573 Informative Direct
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 0.0007365 Informative Direct
Biological Process (BP) positive regulation of phosphate metabolic process 0.00003408 Informative Direct
Biological Process (BP) regulation of secretion 0.0000635 Informative Direct
Biological Process (BP) positive regulation of developmental process 0.0000003592 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0 Informative Direct
Biological Process (BP) regulation of cellular component movement 0 Informative Direct
Biological Process (BP) regulation of transferase activity 0.00000001903 Informative Direct
Biological Process (BP) localization of cell 0.000000001208 Informative Direct
Biological Process (BP) negative regulation of cell death 0.000008466 Informative Direct
Biological Process (BP) regulation of intracellular signal transduction 0.00000002103 Informative Direct
Biological Process (BP) negative regulation of transport 0.07516 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.03892 Informative Inherited
Biological Process (BP) regulation of cell cycle 0.5343 Informative Inherited
Biological Process (BP) regulation of protein localization 1 Informative Inherited
Biological Process (BP) epithelium development 0.2854 Informative Inherited
Biological Process (BP) regulation of peptide transport 0.1494 Informative Inherited
Biological Process (BP) positive regulation of transport 0.004105 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.4689 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) secretion by cell 0.01111 Informative Inherited
Biological Process (BP) response to metal ion 0.007658 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.109 Informative Inherited
Biological Process (BP) response to organic cyclic compound 1 Informative Inherited
Biological Process (BP) response to nitrogen compound 1 Informative Inherited
Biological Process (BP) regulation of cell differentiation 0.0261 Informative Inherited
Biological Process (BP) system process 0.8611 Informative Inherited
Biological Process (BP) embryo development 0.4006 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 1 Informative Inherited
Biological Process (BP) central nervous system development 0.4254 Informative Inherited
Biological Process (BP) cell death 0.08622 Informative Inherited
Biological Process (BP) circulatory system development 0.1835 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.001379 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.004027 Informative Inherited
Biological Process (BP) MAPK cascade 0 Highly Informative Direct
Biological Process (BP) positive regulation of cytokine production 0.0007645 Highly Informative Direct
Biological Process (BP) kidney development 0.00000000000002436 Highly Informative Direct
Biological Process (BP) morphogenesis of an epithelium 0.0003119 Highly Informative Direct
Biological Process (BP) apoptotic process 0.0000204 Highly Informative Direct
Biological Process (BP) inflammatory response 0.00001054 Highly Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.00000000001672 Highly Informative Direct
Biological Process (BP) cell-cell signaling 0 Highly Informative Direct
Biological Process (BP) cell proliferation 0 Highly Informative Direct
Biological Process (BP) response to heat 0.000000000002679 Highly Informative Direct
Biological Process (BP) regulation of epithelial cell migration 0.00000000061 Highly Informative Direct
Biological Process (BP) organic hydroxy compound transport 0.00000002201 Highly Informative Direct
Biological Process (BP) cytokine-mediated signaling pathway 0.0005292 Highly Informative Direct
Biological Process (BP) positive regulation of cell migration 0.0001525 Highly Informative Direct
Biological Process (BP) tube morphogenesis 0.000000000000114 Highly Informative Direct
Biological Process (BP) granulocyte activation 0.0001103 Highly Informative Direct
Biological Process (BP) gliogenesis 0.00000000004319 Highly Informative Direct
Biological Process (BP) regulation of MAP kinase activity 0.0003137 Highly Informative Direct
Biological Process (BP) positive regulation of MAPK cascade 0.0000005325 Highly Informative Direct
Biological Process (BP) positive regulation of angiogenesis 0.0000003326 Highly Informative Direct
Biological Process (BP) positive regulation of lipid metabolic process 0.000000001839 Highly Informative Direct
Biological Process (BP) positive regulation of transcription from RNA polymerase II promoter 0.0008013 Highly Informative Direct
Biological Process (BP) response to copper ion 0 Highly Informative Direct
Biological Process (BP) appendage development 0.0001641 Highly Informative Direct
Biological Process (BP) regulation of lymphocyte proliferation 0.0000001737 Highly Informative Direct
Biological Process (BP) regulation of cytokine secretion 0.000007507 Highly Informative Direct
Biological Process (BP) regulation of steroid biosynthetic process 0 Highly Informative Direct
Biological Process (BP) positive regulation of protein transport 0.0009764 Highly Informative Direct
Biological Process (BP) positive regulation of lymphocyte activation 0 Highly Informative Direct
Biological Process (BP) regulation of cell division 0.0000004425 Highly Informative Direct
Biological Process (BP) positive regulation of leukocyte proliferation 0.000002624 Highly Informative Direct
Biological Process (BP) response to growth factor 0 Highly Informative Direct
Biological Process (BP) positive regulation of protein serine/threonine kinase activity 0.00002826 Highly Informative Direct
Biological Process (BP) negative regulation of secretion by cell 0.0003347 Highly Informative Direct
Biological Process (BP) positive regulation of secretion by cell 0.0005243 Highly Informative Direct
Biological Process (BP) regulation of mitotic cell cycle phase transition 0.1804 Highly Informative Inherited
Biological Process (BP) positive regulation of cell adhesion 0.2705 Highly Informative Inherited
Biological Process (BP) leukocyte migration 0.1612 Highly Informative Inherited
Biological Process (BP) epithelial cell differentiation 0.8666 Highly Informative Inherited
Biological Process (BP) positive regulation of peptide secretion 0.00167 Highly Informative Inherited
Biological Process (BP) regulation of hormone secretion 0.7867 Highly Informative Inherited
Biological Process (BP) lymphocyte activation 0.0518 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.009157 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 0.05756 Highly Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.6607 Highly Informative Inherited
Biological Process (BP) response to molecule of bacterial origin 0.004147 Highly Informative Inherited
Biological Process (BP) embryonic organ development 0.5057 Highly Informative Inherited
Biological Process (BP) sensory organ morphogenesis 0.9587 Highly Informative Inherited
Biological Process (BP) cell chemotaxis 0.03061 Highly Informative Inherited
Biological Process (BP) developmental growth involved in morphogenesis 0.00132 Highly Informative Inherited
Biological Process (BP) heart development 0.08922 Highly Informative Inherited
Biological Process (BP) camera-type eye development 0.003682 Highly Informative Inherited
Biological Process (BP) gastrulation 0.8613 Highly Informative Inherited
Biological Process (BP) activation of protein kinase activity 0.001167 Highly Informative Inherited
Molecular Function (MF) binding 0.000000000000168 Least Informative Direct
Molecular Function (MF) transferase activity 0.7624 Least Informative Inherited
Molecular Function (MF) metal ion binding 0.00003243 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.0000001619 Moderately Informative Direct
Molecular Function (MF) molecular function regulator 0.000000007333 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.008665 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.5359 Moderately Informative Inherited
Molecular Function (MF) receptor binding 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.0003349 Informative Direct
Molecular Function (MF) sulfur compound binding 0 Informative Direct
Molecular Function (MF) kinase activity 0.001176 Informative Inherited
Molecular Function (MF) macromolecular complex binding 0.004374 Informative Inherited
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0.00000003856 Highly Informative Direct
Molecular Function (MF) copper ion binding 0 Highly Informative Direct
Molecular Function (MF) heparin binding 0 Highly Informative Direct
Molecular Function (MF) cell adhesion molecule binding 0.0000007001 Highly Informative Direct
Molecular Function (MF) cytokine receptor binding 1 Highly Informative Inherited
Molecular Function (MF) protein kinase activity 0.001928 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 0.8439 Least Informative Inherited
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) extracellular space 0 Informative Direct
Cellular Component (CC) cell surface 0.0001765 Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation0Moderately InformativeDirect
Biological processImmunity0.00000009808Moderately InformativeDirect
Biological processAngiogenesis0InformativeDirect
Biological processInflammatory response0InformativeDirect
Biological processInnate immunity0.0000000003334InformativeDirect
Biological processNeurogenesis0.00002424InformativeDirect
Cellular componentCytoplasmic vesicle0Moderately InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentLysosome0InformativeDirect
DiseaseProto-oncogene0.00002712Moderately InformativeDirect
DomainSignal0Least InformativeDirect
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationHeparin-binding0InformativeDirect
Post-translational modificationCytokine0Highly InformativeDirect
Post-translational modificationGrowth factor0Highly InformativeDirect
Post-translational modificationMitogen0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR008996 SSF50353 Protein matches
Abstract

Human basic fibroblast growth factor (hFGF-2)1 is a globular single chain heparin-binding polypeptide synthesized by different cell types and is involved in processes associated with proliferation and differentiation of cells. The determination of the three-dimensional structure of hFGF-2 by x-ray crystallography revealed a complex all beta-sheet protein without any disulphide bond. The overall structure shows strong homology with the fold of interleukin-1 and can be described as a trigonal pyramid with three topological units consisting each of four anti-parallel beta-sheets, giving the molecules internal pseudo three-fold symmetry. Both proteins share only 10-13% sequence identity, but superposition of their carbon backbone involves 9 of the 12 beta-sheet strands, including the anti-parallel beta-sheet incorporating the N- and C-terminal regions of the molecules [PubMed10567376].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 18 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Cytokine domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 18 hidden Markov models representing the Cytokine superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]