SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.


Cytokine superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   beta-Trefoil [ 50352] (8)
Superfamily:   Cytokine [ 50353] (2)
Families:   Fibroblast growth factors (FGF) [ 50354] (9)
  Interleukin-1 (IL-1) [ 50362] (5)


Superfamily statistics
Genomes (147) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 2,542 5,601 61
Proteins 2,487 5,505 61


Functional annotation
General category Processes_EC
Detailed category Immune response

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus0.0000000018350Least InformativeDirect
Biological Process (BP)biological regulation00Least InformativeDirect
Biological Process (BP)single-organism cellular process10.002794Least InformativeInherited
Biological Process (BP)immune system process0.000023690Moderately InformativeDirect
Biological Process (BP)cell communication0.0000000000000960Moderately InformativeDirect
Biological Process (BP)anatomical structure morphogenesis0.0000000087780.000001436Moderately InformativeDirect
Biological Process (BP)positive regulation of metabolic process0.0003220.0004371Moderately InformativeDirect
Biological Process (BP)regulation of cell communication0.00010160.0000000004414Moderately InformativeDirect
Biological Process (BP)regulation of signaling0.0001250.0000000005295Moderately InformativeDirect
Biological Process (BP)regulation of localization0.00019080Moderately InformativeDirect
Biological Process (BP)single organism signaling0.00000000098510Moderately InformativeDirect
Biological Process (BP)system development0.0004460.0003939Moderately InformativeDirect
Biological Process (BP)regulation of developmental process0.00000000001090.000000004733Moderately InformativeDirect
Biological Process (BP)regulation of multicellular organismal process00Moderately InformativeDirect
Biological Process (BP)cellular response to chemical stimulus0.000010620.00000000507Moderately InformativeDirect
Biological Process (BP)regulation of macromolecule biosynthetic process0.052741Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process0.1131Moderately InformativeInherited
Biological Process (BP)response to organic substance0.000000000000025970.004822Moderately InformativeInherited
Biological Process (BP)cellular developmental process0.066250.4868Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.020581Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.11231Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.024010.000001788Moderately InformativeInherited
Biological Process (BP)regulation of response to stimulus0.002850.000001139Moderately InformativeInherited
Biological Process (BP)regulation of molecular function0.11230.01674Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.46480.9237Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.37480.4368Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.018940.00000000009053Moderately InformativeInherited
Biological Process (BP)cell surface receptor signaling pathway0.00000022340.0000000001304InformativeDirect
Biological Process (BP)cell-cell signaling0.00055430InformativeDirect
Biological Process (BP)response to temperature stimulus0.0000001110InformativeDirect
Biological Process (BP)animal organ morphogenesis00.000002335InformativeDirect
Biological Process (BP)tissue development0.00000000014540.0000000002863InformativeDirect
Biological Process (BP)positive regulation of signal transduction0.0000095710.0000007725InformativeDirect
Biological Process (BP)positive regulation of gene expression0.0000016740.0001453InformativeDirect
Biological Process (BP)regulation of lipid metabolic process0.000000004310.0000000009298InformativeDirect
Biological Process (BP)regulation of anatomical structure morphogenesis0.0000000016110.0000001125InformativeDirect
Biological Process (BP)positive regulation of cellular protein metabolic process0.00031390.00000000001247InformativeDirect
Biological Process (BP)growth0.00000000000014390.0000001583InformativeDirect
Biological Process (BP)regulation of locomotion0.000000013420.000000000000001945InformativeDirect
Biological Process (BP)regulation of cell proliferation0.000000000013870InformativeDirect
Biological Process (BP)regulation of phosphorylation0.0000000000012230InformativeDirect
Biological Process (BP)positive regulation of catalytic activity0.00000000014710.0009923InformativeDirect
Biological Process (BP)positive regulation of nucleobase-containing compound metabolic process0.000038420.0008386InformativeDirect
Biological Process (BP)positive regulation of phosphate metabolic process0.00000000000008950.00003709InformativeDirect
Biological Process (BP)regulation of secretion0.000045190.00005201InformativeDirect
Biological Process (BP)positive regulation of developmental process0.000000000024330.000001278InformativeDirect
Biological Process (BP)positive regulation of multicellular organismal process0.0000000000000061020InformativeDirect
Biological Process (BP)regulation of cellular component movement0.000000002820InformativeDirect
Biological Process (BP)regulation of transferase activity0.0000000000010130.0000000186InformativeDirect
Biological Process (BP)regulation of establishment of protein localization0.00036490.0000000001304InformativeDirect
Biological Process (BP)positive regulation of transport0.9520.003826InformativeInherited
Biological Process (BP)regulation of cytokine production0.52120.00132InformativeInherited
Biological Process (BP)regulation of peptide transport0.032180.1648InformativeInherited
Biological Process (BP)positive regulation of cellular biosynthetic process0.00012760.1108InformativeInherited
Biological Process (BP)positive regulation of macromolecule biosynthetic process0.000024980.03212InformativeInherited
Biological Process (BP)regulation of transcription, DNA-templated0.015870.8353InformativeInherited
Biological Process (BP)regulation of intracellular signal transduction0.0032060.00000004569InformativeInherited
Biological Process (BP)regulation of cell differentiation0.15610.03216InformativeInherited
Biological Process (BP)cell activation0.0012340.000000009996InformativeInherited
Biological Process (BP)regulation of protein modification process0.0092760.0000008191InformativeInherited
Biological Process (BP)embryo development0.22310.3148InformativeInherited
Biological Process (BP)anatomical structure formation involved in morphogenesis0.0088580.001603InformativeInherited
Biological Process (BP)kidney development00.0000000000000109Highly InformativeDirect
Biological Process (BP)regulation of transcription from RNA polymerase II promoter00.0008695Highly InformativeDirect
Biological Process (BP)transmembrane receptor protein tyrosine kinase signaling pathway00Highly InformativeDirect
Biological Process (BP)cell proliferation0.00003090.000000000000003764Highly InformativeDirect
Biological Process (BP)response to heat0.000012790.0000000000007347Highly InformativeDirect
Biological Process (BP)regulation of epithelial cell migration0.000074210.0000000005315Highly InformativeDirect
Biological Process (BP)positive regulation of cell migration0.00015760.0002445Highly InformativeDirect
Biological Process (BP)tube morphogenesis00.00000000000002124Highly InformativeDirect
Biological Process (BP)regulation of MAP kinase activity0.000041930.0003129Highly InformativeDirect
Biological Process (BP)positive regulation of MAPK cascade0.00071740.0000009158Highly InformativeDirect
Biological Process (BP)positive regulation of angiogenesis0.00047880.0000008146Highly InformativeDirect
Biological Process (BP)positive regulation of lipid metabolic process0.00000000084510.000000003391Highly InformativeDirect
Biological Process (BP)positive regulation of transcription, DNA-templated0.000004890.0005977Highly InformativeDirect
Biological Process (BP)regulation of lymphocyte proliferation0.000062260.0000001587Highly InformativeDirect
Biological Process (BP)regulation of steroid biosynthetic process00Highly InformativeDirect
Biological Process (BP)positive regulation of lymphocyte activation0.000046220Highly InformativeDirect
Biological Process (BP)regulation of cell division0.000000000000220.0000004145Highly InformativeDirect
Biological Process (BP)developmental growth involved in morphogenesis0.00006710.0009662Highly InformativeDirect
Biological Process (BP)cellular response to growth factor stimulus0.000000000000017570Highly InformativeDirect
Biological Process (BP)positive regulation of protein serine/threonine kinase activity00.0000393Highly InformativeDirect
Biological Process (BP)positive regulation of cytokine production0.95950.0006463Highly InformativeInherited
Biological Process (BP)positive regulation of peptide secretion0.047180.00166Highly InformativeInherited
Biological Process (BP)positive regulation of protein transport0.019290.001079Highly InformativeInherited
Biological Process (BP)positive regulation of secretion by cell0.26110.0004662Highly InformativeInherited
Biological Process (BP)regulation of cytokine secretion0.024620.000006626Highly InformativeInherited
Biological Process (BP)epithelial cell differentiation0.34540.8225Highly InformativeInherited
Biological Process (BP)morphogenesis of an epithelium0.019780.000255Highly InformativeInherited
Biological Process (BP)lymphocyte activation0.0000014090.03641Highly InformativeInherited
Biological Process (BP)appendage development0.0084720.00009515Highly InformativeInherited
Biological Process (BP)positive regulation of leukocyte proliferation0.78350.000001761Highly InformativeInherited
Biological Process (BP)activation of protein kinase activity0.12070.001487Highly InformativeInherited
Biological Process (BP)gastrulation0.39320.8835Highly InformativeInherited
Molecular Function (MF)binding0.000000072070.00000000000001324Least InformativeDirect
Molecular Function (MF)carbohydrate derivative binding0.00000000014870.00000237Moderately InformativeDirect
Molecular Function (MF)anion binding0.0000000000008790.6214Moderately InformativeInherited
Molecular Function (MF)receptor binding00InformativeDirect
Molecular Function (MF)sulfur compound binding00InformativeDirect
Molecular Function (MF)macromolecular complex binding0.000000000018240.004461InformativeInherited
Molecular Function (MF)heparin binding00Highly InformativeDirect
Molecular Function (MF)cell adhesion molecule binding00.0000009093Highly InformativeDirect
Molecular Function (MF)cytokine receptor binding11Highly InformativeInherited
Cellular Component (CC)cytoplasmic part0.37490.753Least InformativeInherited
Cellular Component (CC)extracellular region part00Moderately InformativeDirect
Cellular Component (CC)extracellular space00InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) primary metabolic process 0.9829 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 0.2939 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.002794 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 0.1578 Least Informative Inherited
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.00000841 Moderately Informative Direct
Biological Process (BP) cell communication 0 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.000001436 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0.0004371 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 0.0000000004414 Moderately Informative Direct
Biological Process (BP) regulation of signaling 0.0000000005295 Moderately Informative Direct
Biological Process (BP) regulation of localization 0 Moderately Informative Direct
Biological Process (BP) single organism signaling 0 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.000001788 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0.000001139 Moderately Informative Direct
Biological Process (BP) system development 0.0003939 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.000000004733 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.00000000009053 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.00000000507 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.004822 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.6305 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.119 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.9237 Moderately Informative Inherited
Biological Process (BP) response to biotic stimulus 0.676 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.01674 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.04579 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 0.4868 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.1489 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.6324 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.4368 Moderately Informative Inherited
Biological Process (BP) cell activation 0.000000009996 Informative Direct
Biological Process (BP) cell surface receptor signaling pathway 0.0000000001304 Informative Direct
Biological Process (BP) cell-cell signaling 0 Informative Direct
Biological Process (BP) response to temperature stimulus 0 Informative Direct
Biological Process (BP) response to bacterium 0.0002919 Informative Direct
Biological Process (BP) animal organ morphogenesis 0.000002335 Informative Direct
Biological Process (BP) tissue development 0.0000000002863 Informative Direct
Biological Process (BP) positive regulation of signal transduction 0.0000007725 Informative Direct
Biological Process (BP) positive regulation of gene expression 0.0001453 Informative Direct
Biological Process (BP) regulation of hormone levels 0.0001248 Informative Direct
Biological Process (BP) lipid localization 0.00001926 Informative Direct
Biological Process (BP) phosphorylation 0.0000004049 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 0.0000000009298 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.0000001125 Informative Direct
Biological Process (BP) regulation of protein modification process 0.0000008191 Informative Direct
Biological Process (BP) positive regulation of cellular protein metabolic process 0.00000000001247 Informative Direct
Biological Process (BP) growth 0.0000001583 Informative Direct
Biological Process (BP) locomotion 0.000000000006092 Informative Direct
Biological Process (BP) regulation of locomotion 0.000000000000001945 Informative Direct
Biological Process (BP) regulation of cell proliferation 0 Informative Direct
Biological Process (BP) regulation of phosphorylation 0 Informative Direct
Biological Process (BP) positive regulation of catalytic activity 0.0009923 Informative Direct
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 0.0008386 Informative Direct
Biological Process (BP) positive regulation of phosphate metabolic process 0.00003709 Informative Direct
Biological Process (BP) regulation of secretion 0.00005201 Informative Direct
Biological Process (BP) positive regulation of developmental process 0.000001278 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0 Informative Direct
Biological Process (BP) regulation of cellular component movement 0 Informative Direct
Biological Process (BP) regulation of transferase activity 0.0000000186 Informative Direct
Biological Process (BP) negative regulation of cell death 0.00001046 Informative Direct
Biological Process (BP) regulation of establishment of protein localization 0.0000000001304 Informative Direct
Biological Process (BP) regulation of intracellular signal transduction 0.00000004569 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0.003364 Informative Inherited
Biological Process (BP) negative regulation of transport 0.0694 Informative Inherited
Biological Process (BP) regulation of cell cycle 0.4957 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.00132 Informative Inherited
Biological Process (BP) regulation of peptide transport 0.1648 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.1108 Informative Inherited
Biological Process (BP) positive regulation of transport 0.003826 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.3349 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) response to metal ion 0.00765 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.03212 Informative Inherited
Biological Process (BP) regulation of transcription, DNA-templated 0.8353 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 1 Informative Inherited
Biological Process (BP) regulation of cell differentiation 0.03216 Informative Inherited
Biological Process (BP) secretion by cell 0.01043 Informative Inherited
Biological Process (BP) system process 0.8089 Informative Inherited
Biological Process (BP) sensory organ development 0.08051 Informative Inherited
Biological Process (BP) central nervous system development 0.5846 Informative Inherited
Biological Process (BP) cell death 0.07196 Informative Inherited
Biological Process (BP) circulatory system development 0.1205 Informative Inherited
Biological Process (BP) embryo development 0.3148 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.001603 Informative Inherited
Biological Process (BP) MAPK cascade 0 Highly Informative Direct
Biological Process (BP) angiogenesis 0.000792 Highly Informative Direct
Biological Process (BP) positive regulation of cytokine production 0.0006463 Highly Informative Direct
Biological Process (BP) kidney development 0.0000000000000109 Highly Informative Direct
Biological Process (BP) morphogenesis of an epithelium 0.000255 Highly Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.0008695 Highly Informative Direct
Biological Process (BP) apoptotic process 0.00001702 Highly Informative Direct
Biological Process (BP) inflammatory response 0.000004826 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0 Highly Informative Direct
Biological Process (BP) cell proliferation 0.000000000000003764 Highly Informative Direct
Biological Process (BP) response to heat 0.0000000000007347 Highly Informative Direct
Biological Process (BP) regulation of epithelial cell migration 0.0000000005315 Highly Informative Direct
Biological Process (BP) organic hydroxy compound transport 0.00000001763 Highly Informative Direct
Biological Process (BP) positive regulation of cell migration 0.0002445 Highly Informative Direct
Biological Process (BP) tube morphogenesis 0.00000000000002124 Highly Informative Direct
Biological Process (BP) gliogenesis 0.000000005218 Highly Informative Direct
Biological Process (BP) regulation of MAP kinase activity 0.0003129 Highly Informative Direct
Biological Process (BP) positive regulation of MAPK cascade 0.0000009158 Highly Informative Direct
Biological Process (BP) positive regulation of angiogenesis 0.0000008146 Highly Informative Direct
Biological Process (BP) positive regulation of lipid metabolic process 0.000000003391 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-templated 0.0005977 Highly Informative Direct
Biological Process (BP) response to copper ion 0 Highly Informative Direct
Biological Process (BP) appendage development 0.00009515 Highly Informative Direct
Biological Process (BP) inner ear development 0.0002949 Highly Informative Direct
Biological Process (BP) regulation of lymphocyte proliferation 0.0000001587 Highly Informative Direct
Biological Process (BP) regulation of cytokine secretion 0.000006626 Highly Informative Direct
Biological Process (BP) regulation of steroid biosynthetic process 0 Highly Informative Direct
Biological Process (BP) positive regulation of lymphocyte activation 0 Highly Informative Direct
Biological Process (BP) regulation of cell division 0.0000004145 Highly Informative Direct
Biological Process (BP) developmental growth involved in morphogenesis 0.0009662 Highly Informative Direct
Biological Process (BP) positive regulation of leukocyte proliferation 0.000001761 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 0 Highly Informative Direct
Biological Process (BP) positive regulation of protein serine/threonine kinase activity 0.0000393 Highly Informative Direct
Biological Process (BP) negative regulation of secretion by cell 0.000279 Highly Informative Direct
Biological Process (BP) positive regulation of secretion by cell 0.0004662 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.01022 Highly Informative Inherited
Biological Process (BP) positive regulation of peptide secretion 0.00166 Highly Informative Inherited
Biological Process (BP) positive regulation of protein transport 0.001079 Highly Informative Inherited
Biological Process (BP) epithelial cell differentiation 0.8225 Highly Informative Inherited
Biological Process (BP) regulation of hormone secretion 0.7598 Highly Informative Inherited
Biological Process (BP) signal release 0.16 Highly Informative Inherited
Biological Process (BP) lymphocyte activation 0.03641 Highly Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.6596 Highly Informative Inherited
Biological Process (BP) response to molecule of bacterial origin 0.00651 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 1 Highly Informative Inherited
Biological Process (BP) sensory organ morphogenesis 0.9181 Highly Informative Inherited
Biological Process (BP) brain development 0.02538 Highly Informative Inherited
Biological Process (BP) leukocyte migration 0.2835 Highly Informative Inherited
Biological Process (BP) chemotaxis 0.01315 Highly Informative Inherited
Biological Process (BP) positive regulation of cell adhesion 0.2643 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 0.06277 Highly Informative Inherited
Biological Process (BP) gastrulation 0.8835 Highly Informative Inherited
Biological Process (BP) activation of protein kinase activity 0.001487 Highly Informative Inherited
Molecular Function (MF) binding 0.00000000000001324 Least Informative Direct
Molecular Function (MF) transferase activity 0.7207 Least Informative Inherited
Molecular Function (MF) metal ion binding 0.00002172 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.00000237 Moderately Informative Direct
Molecular Function (MF) molecular function regulator 0.00000000415 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.007016 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.6214 Moderately Informative Inherited
Molecular Function (MF) receptor binding 0 Informative Direct
Molecular Function (MF) kinase activity 0.0009509 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.0002651 Informative Direct
Molecular Function (MF) sulfur compound binding 0 Informative Direct
Molecular Function (MF) macromolecular complex binding 0.004461 Informative Inherited
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0.00000002965 Highly Informative Direct
Molecular Function (MF) copper ion binding 0 Highly Informative Direct
Molecular Function (MF) heparin binding 0 Highly Informative Direct
Molecular Function (MF) cell adhesion molecule binding 0.0000009093 Highly Informative Direct
Molecular Function (MF) cytokine receptor binding 1 Highly Informative Inherited
Molecular Function (MF) protein kinase activity 0.001807 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 0.753 Least Informative Inherited
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) extracellular space 0 Informative Direct
Cellular Component (CC) cell surface 0.0001103 Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.4933Least InformativeInherited
Disease Ontology (DO)endocrine system disease0.0007027Moderately InformativeDirect
Disease Ontology (DO)skin disease0.0007669Moderately InformativeDirect
Disease Ontology (DO)lower respiratory tract disease0.02872Moderately InformativeInherited
Disease Ontology (DO)connective tissue disease0.03285Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.04262Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.1006Moderately InformativeInherited
Disease Ontology (DO)sensory system disease0.185Moderately InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.2074Moderately InformativeInherited
Disease Ontology (DO)disease by infectious agent0.4963Moderately InformativeInherited
Disease Ontology (DO)periodontal disease0.00001039InformativeDirect
Disease Ontology (DO)physical disorder0.00002227InformativeDirect
Disease Ontology (DO)bullous pemphigoid0.00009014InformativeDirect
Disease Ontology (DO)hemorrhagic disease0.001259InformativeInherited
Disease Ontology (DO)female reproductive system disease0.001632InformativeInherited
Disease Ontology (DO)parasitic protozoa infectious disease0.006457InformativeInherited
Disease Ontology (DO)arthropathy0.01945InformativeInherited
Disease Ontology (DO)interstitial lung disease0.02441InformativeInherited
Disease Ontology (DO)purpura0.0001098Highly InformativeDirect
Disease Ontology (DO)obstructive lung disease0.0001365Highly InformativeDirect
Disease Ontology (DO)Behcet's disease0.0001395Highly InformativeDirect
Disease Ontology (DO)primary open angle glaucoma0.0002917Highly InformativeDirect
Disease Ontology (DO)endometriosis0.0004523Highly InformativeDirect
Disease Ontology (DO)gastritis0.0009957Highly InformativeDirect
Disease Ontology (DO)spondylitis0.0009957Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the face0.03847Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the oral cavity0.4099Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of dental morphology0.07945Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.04062Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.3974Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.9625Least InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.001155Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.01577Moderately InformativeInherited
Mammalian Phenotype (MP)hearing/vestibular/ear phenotype0.07125Moderately InformativeInherited
Mammalian Phenotype (MP)embryo phenotype0.2777Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.8115Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal limb morphology0.0133InformativeInherited
Mammalian Phenotype (MP)abnormal systemic artery morphology0.152InformativeInherited
Mammalian Phenotype (MP)abnormal coat appearance1InformativeInherited
Mammalian Phenotype (MP)abnormal right subclavian artery morphology0.0002679Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart atrium morphology0.0006267Highly InformativeDirect
Mammalian Phenotype (MP)abnormal body temperature homeostasis0.000817Highly InformativeDirect
Mammalian Phenotype (MP)abnormal aortic arch morphology0.0054Highly InformativeInherited
Mammalian Phenotype (MP)abnormal forelimb morphology0.0652Highly InformativeInherited
Mammalian Phenotype (MP)abnormal hair growth0.1838Highly InformativeInherited

Document: MP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0Least InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)nervous system0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect
Fly Anatomy (FA)somatic cell0Least InformativeDirect
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)central nervous system0Moderately InformativeDirect
Fly Anatomy (FA)late embryo0Moderately InformativeDirect
Fly Anatomy (FA)developing material anatomical entity0Moderately InformativeDirect
Fly Anatomy (FA)abdominal segment0InformativeDirect
Fly Anatomy (FA)extended germ band embryo0InformativeDirect
Fly Anatomy (FA)dorsal closure embryo0InformativeDirect
Fly Anatomy (FA)primordium0InformativeDirect
Fly Anatomy (FA)CNS glial cell0Highly InformativeDirect
Fly Anatomy (FA)late extended germ band embryo0Highly InformativeDirect
Fly Anatomy (FA)early extended germ band embryo0Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)compound organ0.1978Least InformativeInherited
Zebrafish Anatomy (ZA)organism subdivision0.2789Least InformativeInherited
Zebrafish Anatomy (ZA)anatomical cluster0.1246Moderately InformativeInherited
Zebrafish Anatomy (ZA)head0.6551Moderately InformativeInherited
Zebrafish Anatomy (ZA)skeletal element0.0007353InformativeDirect
Zebrafish Anatomy (ZA)surface structure0.01198InformativeInherited
Zebrafish Anatomy (ZA)cranium0.04654InformativeInherited
Zebrafish Anatomy (ZA)pectoral fin0.00007144Highly InformativeDirect
Zebrafish Anatomy (ZA)intramembranous bone0.0001797Highly InformativeDirect
Zebrafish Anatomy (ZA)embryonic structure0.01963Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.0005178Least InformativeDirect
Xenopus ANatomical entity (XAN)tissue0.01257Least InformativeInherited
Xenopus ANatomical entity (XAN)nervous system0.05006Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.1178Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical cluster1Least InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.0000006358Moderately InformativeDirect
Xenopus ANatomical entity (XAN)multi-tissue structure0.003238Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.1198Moderately InformativeInherited
Xenopus ANatomical entity (XAN)brain0.1701Moderately InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.4434Moderately InformativeInherited
Xenopus ANatomical entity (XAN)visual system0.85Moderately InformativeInherited
Xenopus ANatomical entity (XAN)alimentary system1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)neuroectoderm0.0000000001383InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0.00000001952InformativeDirect
Xenopus ANatomical entity (XAN)pharyngeal region0.0000003021InformativeDirect
Xenopus ANatomical entity (XAN)forebrain0.000003451InformativeDirect
Xenopus ANatomical entity (XAN)notochord0.00003122InformativeDirect
Xenopus ANatomical entity (XAN)anatomical direction0.00003781InformativeDirect
Xenopus ANatomical entity (XAN)hindbrain0.00005255InformativeDirect
Xenopus ANatomical entity (XAN)vestibuloauditory system0.00006874InformativeDirect
Xenopus ANatomical entity (XAN)peripheral nervous system0.002715InformativeInherited
Xenopus ANatomical entity (XAN)tail0.007673InformativeInherited
Xenopus ANatomical entity (XAN)skeletal system0.3002InformativeInherited
Xenopus ANatomical entity (XAN)limb0.7989InformativeInherited
Xenopus ANatomical entity (XAN)lens0.00000001703Highly InformativeDirect
Xenopus ANatomical entity (XAN)chordoneural hinge0.0000006591Highly InformativeDirect
Xenopus ANatomical entity (XAN)neurogenic placode0.0000008393Highly InformativeDirect
Xenopus ANatomical entity (XAN)cranial neural crest0.000004895Highly InformativeDirect
Xenopus ANatomical entity (XAN)hindlimb0.000006841Highly InformativeDirect
Xenopus ANatomical entity (XAN)otic vesicle0.0001089Highly InformativeDirect
Xenopus ANatomical entity (XAN)limb bud0.0001151Highly InformativeDirect
Xenopus ANatomical entity (XAN)neural tube0.0001565Highly InformativeDirect
Xenopus ANatomical entity (XAN)somite0.000164Highly InformativeDirect
Xenopus ANatomical entity (XAN)foregut0.0001965Highly InformativeDirect
Xenopus ANatomical entity (XAN)regenerating tissue0.0002432Highly InformativeDirect
Xenopus ANatomical entity (XAN)cranium0.0002718Highly InformativeDirect
Xenopus ANatomical entity (XAN)mesenchyme0.0003291Highly InformativeDirect
Xenopus ANatomical entity (XAN)olfactory system0.00083Highly InformativeDirect
Xenopus ANatomical entity (XAN)ganglion0.004193Highly InformativeInherited
Xenopus DEvelopment stage (XDE)NF stage0.01837Least InformativeInherited
Xenopus DEvelopment stage (XDE)embryonic stage0.0341Least InformativeInherited
Xenopus DEvelopment stage (XDE)late tailbud stage0.05198InformativeInherited
Xenopus DEvelopment stage (XDE)NF stage 400.0001046Highly InformativeDirect

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation0Moderately InformativeDirect
Biological processImmunity0.00000006742Moderately InformativeDirect
Biological processAngiogenesis0InformativeDirect
Biological processInflammatory response0InformativeDirect
Biological processInnate immunity0.0000000003178InformativeDirect
Biological processNeurogenesis0.00002408InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0Moderately InformativeDirect
Cellular componentLysosome0InformativeDirect
DiseaseProto-oncogene0.00002753Moderately InformativeDirect
DomainSignal0Least InformativeDirect
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationHeparin-binding0InformativeDirect
Post-translational modificationCytokine0Highly InformativeDirect
Post-translational modificationGrowth factor0Highly InformativeDirect
Post-translational modificationMitogen0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR008996 SSF50353 Protein matches
Abstract

Human basic fibroblast growth factor (hFGF-2)1 is a globular single chain heparin-binding polypeptide synthesized by different cell types and is involved in processes associated with proliferation and differentiation of cells. The determination of the three-dimensional structure of hFGF-2 by x-ray crystallography revealed a complex all beta-sheet protein without any disulphide bond. The overall structure shows strong homology with the fold of interleukin-1 and can be described as a trigonal pyramid with three topological units consisting each of four anti-parallel beta-sheets, giving the molecules internal pseudo three-fold symmetry. Both proteins share only 10-13% sequence identity, but superposition of their carbon backbone involves 9 of the 12 beta-sheet strands, including the anti-parallel beta-sheet incorporating the N- and C-terminal regions of the molecules [PubMed10567376].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 18 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Cytokine domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 18 hidden Markov models representing the Cytokine superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]