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Cytokine superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   beta-Trefoil [ 50352] (8)
Superfamily:   Cytokine [ 50353] (2)
Families:   Fibroblast growth factors (FGF) [ 50354] (9)
  Interleukin-1 (IL-1) [ 50362] (5)


Superfamily statistics
Genomes (144) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 2,535 3,170 61
Proteins 2,480 3,112 61


Functional annotation
General category Processes_EC
Detailed category Immune response

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus0.00000000036650Least InformativeDirect
Biological Process (BP)biological regulation00Least InformativeDirect
Biological Process (BP)single-organism cellular process0.012350.000001015Least InformativeInherited
Biological Process (BP)immune system process0.0000091990Moderately InformativeDirect
Biological Process (BP)cell communication0.0000000003460Moderately InformativeDirect
Biological Process (BP)anatomical structure morphogenesis0.0000000087680.000001145Moderately InformativeDirect
Biological Process (BP)positive regulation of metabolic process0.00032810.0002364Moderately InformativeDirect
Biological Process (BP)regulation of cell communication0.00023940.000000002525Moderately InformativeDirect
Biological Process (BP)regulation of signaling0.00019420.000000001769Moderately InformativeDirect
Biological Process (BP)signaling00Moderately InformativeDirect
Biological Process (BP)regulation of localization0.00028460Moderately InformativeDirect
Biological Process (BP)system development0.00055470.0005103Moderately InformativeDirect
Biological Process (BP)regulation of developmental process0.000000000018760.00000000686Moderately InformativeDirect
Biological Process (BP)regulation of multicellular organismal process00Moderately InformativeDirect
Biological Process (BP)cellular response to chemical stimulus0.0000039420.000000001811Moderately InformativeDirect
Biological Process (BP)regulation of nitrogen compound metabolic process0.13461Moderately InformativeInherited
Biological Process (BP)regulation of biosynthetic process0.11611Moderately InformativeInherited
Biological Process (BP)regulation of cellular metabolic process0.3381Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.012720.0000000003178Moderately InformativeInherited
Biological Process (BP)response to organic substance0.000000000000022650.007078Moderately InformativeInherited
Biological Process (BP)cellular developmental process0.062580.4592Moderately InformativeInherited
Biological Process (BP)regulation of molecular function0.11360.03092Moderately InformativeInherited
Biological Process (BP)regulation of response to stimulus0.0044790.00000219Moderately InformativeInherited
Biological Process (BP)response to stress0.45430.1631Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.37290.4498Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.033010.000002406Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.060791Moderately InformativeInherited
Biological Process (BP)cell adhesion0.00071970.0000001188InformativeDirect
Biological Process (BP)cell surface receptor signaling pathway0.00000018070.00000000009541InformativeDirect
Biological Process (BP)response to temperature stimulus0.000000097540InformativeDirect
Biological Process (BP)animal organ morphogenesis00.000005145InformativeDirect
Biological Process (BP)positive regulation of signal transduction0.0000094360.0000007326InformativeDirect
Biological Process (BP)positive regulation of gene expression0.0000064440.000105InformativeDirect
Biological Process (BP)regulation of lipid metabolic process0.0000000077210.0000000004536InformativeDirect
Biological Process (BP)regulation of anatomical structure morphogenesis0.0000000053820.0000004547InformativeDirect
Biological Process (BP)positive regulation of cellular protein metabolic process0.0006160.00000000003203InformativeDirect
Biological Process (BP)growth0.00000000000013050.0000001696InformativeDirect
Biological Process (BP)regulation of locomotion0.00000001820.000000000000003692InformativeDirect
Biological Process (BP)regulation of cell proliferation0.000000000047420InformativeDirect
Biological Process (BP)regulation of phosphorylation0.0000000000013420InformativeDirect
Biological Process (BP)positive regulation of catalytic activity0.00000000011490.0003319InformativeDirect
Biological Process (BP)positive regulation of phosphate metabolic process0.000000000000093710.00003303InformativeDirect
Biological Process (BP)regulation of secretion0.000047460.00004309InformativeDirect
Biological Process (BP)positive regulation of developmental process0.0000000000360.00000178InformativeDirect
Biological Process (BP)positive regulation of multicellular organismal process0.000000000000017080InformativeDirect
Biological Process (BP)regulation of cellular component movement0.0000000047580InformativeDirect
Biological Process (BP)regulation of transferase activity0.0000000000012280.000000002227InformativeDirect
Biological Process (BP)positive regulation of nitrogen compound metabolic process0.000091280.009775InformativeInherited
Biological Process (BP)positive regulation of macromolecule biosynthetic process0.00003070.03986InformativeInherited
Biological Process (BP)positive regulation of transport0.95620.004493InformativeInherited
Biological Process (BP)regulation of cytokine production0.52560.002568InformativeInherited
Biological Process (BP)regulation of protein localization11InformativeInherited
Biological Process (BP)positive regulation of cellular biosynthetic process0.00019670.1132InformativeInherited
Biological Process (BP)epithelium development0.0015760.3037InformativeInherited
Biological Process (BP)regulation of protein modification process0.014750.000001596InformativeInherited
Biological Process (BP)regulation of intracellular signal transduction0.0035490.00000008546InformativeInherited
Biological Process (BP)regulation of cell differentiation0.17680.03503InformativeInherited
Biological Process (BP)embryo development0.19440.1931InformativeInherited
Biological Process (BP)positive regulation of immune system process0.9570.0000003953InformativeInherited
Biological Process (BP)anatomical structure formation involved in morphogenesis0.0085730.00198InformativeInherited
Biological Process (BP)leukocyte cell-cell adhesion0.000024120Highly InformativeDirect
Biological Process (BP)transmembrane receptor protein tyrosine kinase signaling pathway00Highly InformativeDirect
Biological Process (BP)cell proliferation0.000021940.00000000000003235Highly InformativeDirect
Biological Process (BP)response to heat0.000012060.000000000000913Highly InformativeDirect
Biological Process (BP)regulation of epithelial cell migration0.000074230.0000000007219Highly InformativeDirect
Biological Process (BP)positive regulation of cell migration0.00010640.0002164Highly InformativeDirect
Biological Process (BP)tube morphogenesis00.000000000003577Highly InformativeDirect
Biological Process (BP)positive regulation of MAPK cascade0.00073910.0000008442Highly InformativeDirect
Biological Process (BP)positive regulation of angiogenesis0.00058280.0000007649Highly InformativeDirect
Biological Process (BP)positive regulation of lipid metabolic process0.0000000012480.000000008121Highly InformativeDirect
Biological Process (BP)regulation of lymphocyte proliferation0.000069940.0000002464Highly InformativeDirect
Biological Process (BP)regulation of steroid biosynthetic process00Highly InformativeDirect
Biological Process (BP)positive regulation of lymphocyte activation0.000050180Highly InformativeDirect
Biological Process (BP)regulation of cell division0.00000000000060030.0000004016Highly InformativeDirect
Biological Process (BP)developmental growth involved in morphogenesis0.000055450.0007744Highly InformativeDirect
Biological Process (BP)cellular response to growth factor stimulus0.000000000000025370Highly InformativeDirect
Biological Process (BP)regulation of protein serine/threonine kinase activity00.0004233Highly InformativeDirect
Biological Process (BP)regulation of cytokine secretion0.020620.000001583Highly InformativeInherited
Biological Process (BP)positive regulation of cytokine production0.96010.0006254Highly InformativeInherited
Biological Process (BP)positive regulation of protein secretion0.016280.000007518Highly InformativeInherited
Biological Process (BP)morphogenesis of an epithelium0.028680.0009203Highly InformativeInherited
Biological Process (BP)epithelial cell differentiation0.30490.7122Highly InformativeInherited
Biological Process (BP)lymphocyte activation0.0000015610.5907Highly InformativeInherited
Biological Process (BP)appendage development0.014420.0001581Highly InformativeInherited
Biological Process (BP)positive regulation of leukocyte proliferation0.78630.000001772Highly InformativeInherited
Biological Process (BP)activation of protein kinase activity0.22230.002138Highly InformativeInherited
Biological Process (BP)gastrulation0.40230.9275Highly InformativeInherited
Molecular Function (MF)binding0.000000043180.000000000000001646Least InformativeDirect
Molecular Function (MF)carbohydrate derivative binding0.00000000017540.000003Moderately InformativeDirect
Molecular Function (MF)protein binding0.00067040.001006Moderately InformativeInherited
Molecular Function (MF)anion binding0.00000000000074330.6085Moderately InformativeInherited
Molecular Function (MF)receptor binding00InformativeDirect
Molecular Function (MF)sulfur compound binding00InformativeDirect
Molecular Function (MF)macromolecular complex binding0.000000000083830.1142InformativeInherited
Molecular Function (MF)heparin binding00Highly InformativeDirect
Molecular Function (MF)cytokine receptor binding0.99321Highly InformativeInherited
Cellular Component (CC)cytoplasmic part0.42550.7623Least InformativeInherited
Cellular Component (CC)extracellular region part00Moderately InformativeDirect
Cellular Component (CC)extracellular space00InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism cellular process 0.000001015 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) macromolecule metabolic process 0.3067 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.9716 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.000007498 Moderately Informative Direct
Biological Process (BP) cell communication 0 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.000001145 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0.0002364 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 0.000000002525 Moderately Informative Direct
Biological Process (BP) regulation of signaling 0.000000001769 Moderately Informative Direct
Biological Process (BP) signaling 0 Moderately Informative Direct
Biological Process (BP) regulation of localization 0 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.000002406 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0.00000219 Moderately Informative Direct
Biological Process (BP) system development 0.0005103 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.00000000686 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.0000000003178 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.000000001811 Moderately Informative Direct
Biological Process (BP) regulation of nitrogen compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.03092 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.0661 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.01419 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.4498 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.007078 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.6893 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.05836 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 0.4592 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.5065 Moderately Informative Inherited
Biological Process (BP) response to stress 0.1631 Moderately Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.0000003953 Informative Direct
Biological Process (BP) cell adhesion 0.0000001188 Informative Direct
Biological Process (BP) cell surface receptor signaling pathway 0.00000000009541 Informative Direct
Biological Process (BP) response to temperature stimulus 0 Informative Direct
Biological Process (BP) response to bacterium 0.0002661 Informative Direct
Biological Process (BP) animal organ morphogenesis 0.000005145 Informative Direct
Biological Process (BP) positive regulation of signal transduction 0.0000007326 Informative Direct
Biological Process (BP) positive regulation of gene expression 0.000105 Informative Direct
Biological Process (BP) regulation of hormone levels 0.00002692 Informative Direct
Biological Process (BP) lipid localization 0.00000555 Informative Direct
Biological Process (BP) phosphorylation 0.0000005641 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 0.0000000004536 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.0000004547 Informative Direct
Biological Process (BP) regulation of protein modification process 0.000001596 Informative Direct
Biological Process (BP) positive regulation of cellular protein metabolic process 0.00000000003203 Informative Direct
Biological Process (BP) growth 0.0000001696 Informative Direct
Biological Process (BP) locomotion 0.000000000002673 Informative Direct
Biological Process (BP) regulation of locomotion 0.000000000000003692 Informative Direct
Biological Process (BP) regulation of cell proliferation 0 Informative Direct
Biological Process (BP) regulation of phosphorylation 0 Informative Direct
Biological Process (BP) positive regulation of catalytic activity 0.0003319 Informative Direct
Biological Process (BP) positive regulation of phosphate metabolic process 0.00003303 Informative Direct
Biological Process (BP) secretion 0.000001379 Informative Direct
Biological Process (BP) regulation of secretion 0.00004309 Informative Direct
Biological Process (BP) positive regulation of developmental process 0.00000178 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0 Informative Direct
Biological Process (BP) regulation of cellular component movement 0 Informative Direct
Biological Process (BP) regulation of transferase activity 0.000000002227 Informative Direct
Biological Process (BP) negative regulation of cell death 0.00001089 Informative Direct
Biological Process (BP) regulation of intracellular signal transduction 0.00000008546 Informative Direct
Biological Process (BP) negative regulation of transport 0.07526 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0.009775 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.03986 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.002568 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.1132 Informative Inherited
Biological Process (BP) movement of cell or subcellular component 0.006396 Informative Inherited
Biological Process (BP) epithelium development 0.3037 Informative Inherited
Biological Process (BP) system process 0.9545 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.00198 Informative Inherited
Biological Process (BP) regulation of protein localization 1 Informative Inherited
Biological Process (BP) positive regulation of transport 0.004493 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) response to inorganic substance 0.2009 Informative Inherited
Biological Process (BP) regulation of cell differentiation 0.03503 Informative Inherited
Biological Process (BP) embryo development 0.1931 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 1 Informative Inherited
Biological Process (BP) regulation of cell cycle 0.4936 Informative Inherited
Biological Process (BP) central nervous system development 0.5576 Informative Inherited
Biological Process (BP) cell death 0.08849 Informative Inherited
Biological Process (BP) circulatory system development 0.1178 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.3121 Informative Inherited
Biological Process (BP) MAPK cascade 0 Highly Informative Direct
Biological Process (BP) angiogenesis 0.0007939 Highly Informative Direct
Biological Process (BP) positive regulation of cytokine production 0.0006254 Highly Informative Direct
Biological Process (BP) morphogenesis of an epithelium 0.0009203 Highly Informative Direct
Biological Process (BP) apoptotic process 0.00001917 Highly Informative Direct
Biological Process (BP) inflammatory response 0.000002722 Highly Informative Direct
Biological Process (BP) leukocyte cell-cell adhesion 0 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0 Highly Informative Direct
Biological Process (BP) cell proliferation 0.00000000000003235 Highly Informative Direct
Biological Process (BP) response to heat 0.000000000000913 Highly Informative Direct
Biological Process (BP) regulation of epithelial cell migration 0.0000000007219 Highly Informative Direct
Biological Process (BP) organic hydroxy compound transport 0.0000000008882 Highly Informative Direct
Biological Process (BP) cell migration 0.00000000001563 Highly Informative Direct
Biological Process (BP) positive regulation of cell migration 0.0002164 Highly Informative Direct
Biological Process (BP) tube morphogenesis 0.000000000003577 Highly Informative Direct
Biological Process (BP) gliogenesis 0.00000000181 Highly Informative Direct
Biological Process (BP) positive regulation of MAPK cascade 0.0000008442 Highly Informative Direct
Biological Process (BP) positive regulation of angiogenesis 0.0000007649 Highly Informative Direct
Biological Process (BP) positive regulation of lipid metabolic process 0.000000008121 Highly Informative Direct
Biological Process (BP) response to copper ion 0.000000000000003692 Highly Informative Direct
Biological Process (BP) appendage development 0.0001581 Highly Informative Direct
Biological Process (BP) inner ear development 0.0002869 Highly Informative Direct
Biological Process (BP) regulation of lymphocyte proliferation 0.0000002464 Highly Informative Direct
Biological Process (BP) regulation of cytokine secretion 0.000001583 Highly Informative Direct
Biological Process (BP) positive regulation of protein secretion 0.000007518 Highly Informative Direct
Biological Process (BP) regulation of steroid biosynthetic process 0 Highly Informative Direct
Biological Process (BP) positive regulation of lymphocyte activation 0 Highly Informative Direct
Biological Process (BP) regulation of cell division 0.0000004016 Highly Informative Direct
Biological Process (BP) developmental growth involved in morphogenesis 0.0007744 Highly Informative Direct
Biological Process (BP) positive regulation of leukocyte proliferation 0.000001772 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 0 Highly Informative Direct
Biological Process (BP) regulation of protein serine/threonine kinase activity 0.0004233 Highly Informative Direct
Biological Process (BP) negative regulation of secretion by cell 0.0002928 Highly Informative Direct
Biological Process (BP) regulation of mitotic cell cycle phase transition 0.1591 Highly Informative Inherited
Biological Process (BP) positive regulation of cell adhesion 0.3005 Highly Informative Inherited
Biological Process (BP) sensory organ morphogenesis 0.8591 Highly Informative Inherited
Biological Process (BP) epithelial cell differentiation 0.7122 Highly Informative Inherited
Biological Process (BP) regulation of hormone secretion 0.7761 Highly Informative Inherited
Biological Process (BP) signal release 0.1849 Highly Informative Inherited
Biological Process (BP) lymphocyte activation 0.5907 Highly Informative Inherited
Biological Process (BP) response to molecule of bacterial origin 0.007069 Highly Informative Inherited
Biological Process (BP) activation of protein kinase activity 0.002138 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 1 Highly Informative Inherited
Biological Process (BP) brain development 0.02303 Highly Informative Inherited
Biological Process (BP) chemotaxis 0.01655 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.02205 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 0.07234 Highly Informative Inherited
Biological Process (BP) gastrulation 0.9275 Highly Informative Inherited
Molecular Function (MF) binding 0.000000000000001646 Least Informative Direct
Molecular Function (MF) transferase activity 0.7553 Least Informative Inherited
Molecular Function (MF) metal ion binding 0.00001709 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.000003 Moderately Informative Direct
Molecular Function (MF) molecular function regulator 0.00000000431 Moderately Informative Direct
Molecular Function (MF) protein binding 0.001006 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.008545 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.6085 Moderately Informative Inherited
Molecular Function (MF) receptor binding 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.0003331 Informative Direct
Molecular Function (MF) sulfur compound binding 0 Informative Direct
Molecular Function (MF) kinase activity 0.001167 Informative Inherited
Molecular Function (MF) macromolecular complex binding 0.1142 Informative Inherited
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0.00000002555 Highly Informative Direct
Molecular Function (MF) copper ion binding 0 Highly Informative Direct
Molecular Function (MF) heparin binding 0 Highly Informative Direct
Molecular Function (MF) cytokine receptor binding 1 Highly Informative Inherited
Molecular Function (MF) protein kinase activity 0.001904 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 0.7623 Least Informative Inherited
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) extracellular space 0 Informative Direct
Cellular Component (CC) cell surface 0.00009461 Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.5066Least InformativeInherited
Disease Ontology (DO)immune system disease0.7922Least InformativeInherited
Disease Ontology (DO)skin disease0.000584Moderately InformativeDirect
Disease Ontology (DO)endocrine system disease0.000728Moderately InformativeDirect
Disease Ontology (DO)blood coagulation disease0.003968Moderately InformativeInherited
Disease Ontology (DO)lower respiratory tract disease0.02917Moderately InformativeInherited
Disease Ontology (DO)connective tissue disease0.03232Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.04127Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.1018Moderately InformativeInherited
Disease Ontology (DO)sensory system disease0.1902Moderately InformativeInherited
Disease Ontology (DO)disease by infectious agent0.4921Moderately InformativeInherited
Disease Ontology (DO)periodontal disease0.000011InformativeDirect
Disease Ontology (DO)physical disorder0.00002251InformativeDirect
Disease Ontology (DO)autoimmune disease of skin and connective tissue0.0009928InformativeDirect
Disease Ontology (DO)hemorrhagic disease0.001269InformativeInherited
Disease Ontology (DO)female reproductive system disease0.001584InformativeInherited
Disease Ontology (DO)parasitic protozoa infectious disease0.006458InformativeInherited
Disease Ontology (DO)arthropathy0.01918InformativeInherited
Disease Ontology (DO)interstitial lung disease0.02417InformativeInherited
Disease Ontology (DO)retinal disease0.02695InformativeInherited
Disease Ontology (DO)purpura0.0001144Highly InformativeDirect
Disease Ontology (DO)Behcet's disease0.0001362Highly InformativeDirect
Disease Ontology (DO)obstructive lung disease0.0001447Highly InformativeDirect
Disease Ontology (DO)primary open angle glaucoma0.0002793Highly InformativeDirect
Disease Ontology (DO)endometriosis0.0004309Highly InformativeDirect
Disease Ontology (DO)spondylitis0.000975Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the face0.03789Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the oral cavity0.4073Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of dental morphology0.07691Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.03342Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.558Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.9632Least InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.003603Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.02307Moderately InformativeInherited
Mammalian Phenotype (MP)embryo phenotype0.4335Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.7806Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal limb morphology0.01522InformativeInherited
Mammalian Phenotype (MP)abnormal systemic artery morphology0.1495InformativeInherited
Mammalian Phenotype (MP)abnormal coat appearance1InformativeInherited
Mammalian Phenotype (MP)abnormal right subclavian artery morphology0.0002831Highly InformativeDirect
Mammalian Phenotype (MP)abnormal body temperature homeostasis0.0008172Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart atrium morphology0.0008549Highly InformativeDirect
Mammalian Phenotype (MP)abnormal aortic arch morphology0.005687Highly InformativeInherited
Mammalian Phenotype (MP)abnormal forelimb morphology0.06296Highly InformativeInherited
Mammalian Phenotype (MP)abnormal hair growth0.19Highly InformativeInherited

Document: MP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0Least InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)nervous system0Least InformativeDirect
Fly Anatomy (FA)cell0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)central nervous system0Moderately InformativeDirect
Fly Anatomy (FA)late embryo0Moderately InformativeDirect
Fly Anatomy (FA)portion of tissue0Moderately InformativeDirect
Fly Anatomy (FA)developing material anatomical entity0Moderately InformativeDirect
Fly Anatomy (FA)abdominal segment0InformativeDirect
Fly Anatomy (FA)extended germ band embryo0InformativeDirect
Fly Anatomy (FA)dorsal closure embryo0InformativeDirect
Fly Anatomy (FA)primordium0InformativeDirect
Fly Anatomy (FA)CNS glial cell0Highly InformativeDirect
Fly Anatomy (FA)late extended germ band embryo0Highly InformativeDirect
Fly Anatomy (FA)early extended germ band embryo0Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)compound organ0.1951Least InformativeInherited
Zebrafish Anatomy (ZA)organism subdivision0.2967Least InformativeInherited
Zebrafish Anatomy (ZA)anatomical cluster0.1284Moderately InformativeInherited
Zebrafish Anatomy (ZA)head0.654Moderately InformativeInherited
Zebrafish Anatomy (ZA)skeletal element0.0007312InformativeDirect
Zebrafish Anatomy (ZA)surface structure0.01249InformativeInherited
Zebrafish Anatomy (ZA)cranium0.04718InformativeInherited
Zebrafish Anatomy (ZA)pectoral fin0.00007643Highly InformativeDirect
Zebrafish Anatomy (ZA)intramembranous bone0.0001819Highly InformativeDirect
Zebrafish Anatomy (ZA)embryonic structure0.01901Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.0004748Least InformativeDirect
Xenopus ANatomical entity (XAN)tissue0.01199Least InformativeInherited
Xenopus ANatomical entity (XAN)nervous system0.04844Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.1161Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical cluster1Least InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.0000005648Moderately InformativeDirect
Xenopus ANatomical entity (XAN)sensory system0.00002231Moderately InformativeDirect
Xenopus ANatomical entity (XAN)multi-tissue structure0.003084Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.12Moderately InformativeInherited
Xenopus ANatomical entity (XAN)brain0.1654Moderately InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.4402Moderately InformativeInherited
Xenopus ANatomical entity (XAN)alimentary system1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)mesoderm0.000000009178InformativeDirect
Xenopus ANatomical entity (XAN)pharyngeal region0.0000001464InformativeDirect
Xenopus ANatomical entity (XAN)forebrain0.000001549InformativeDirect
Xenopus ANatomical entity (XAN)hindbrain0.00002968InformativeDirect
Xenopus ANatomical entity (XAN)anatomical direction0.0000322InformativeDirect
Xenopus ANatomical entity (XAN)vestibuloauditory system0.00003984InformativeDirect
Xenopus ANatomical entity (XAN)notochord0.0003077InformativeDirect
Xenopus ANatomical entity (XAN)peripheral nervous system0.00251InformativeInherited
Xenopus ANatomical entity (XAN)tail0.007462InformativeInherited
Xenopus ANatomical entity (XAN)skeletal system0.2969InformativeInherited
Xenopus ANatomical entity (XAN)limb0.8011InformativeInherited
Xenopus ANatomical entity (XAN)lens0.00000001187Highly InformativeDirect
Xenopus ANatomical entity (XAN)tail tip0.0000003714Highly InformativeDirect
Xenopus ANatomical entity (XAN)neurogenic placode0.0000006717Highly InformativeDirect
Xenopus ANatomical entity (XAN)cranial neural crest0.000002727Highly InformativeDirect
Xenopus ANatomical entity (XAN)hindlimb0.0000069Highly InformativeDirect
Xenopus ANatomical entity (XAN)tail bud0.00001134Highly InformativeDirect
Xenopus ANatomical entity (XAN)otic vesicle0.0000642Highly InformativeDirect
Xenopus ANatomical entity (XAN)somite0.00009605Highly InformativeDirect
Xenopus ANatomical entity (XAN)limb bud0.0001192Highly InformativeDirect
Xenopus ANatomical entity (XAN)neural tube0.0001364Highly InformativeDirect
Xenopus ANatomical entity (XAN)foregut0.0001625Highly InformativeDirect
Xenopus ANatomical entity (XAN)cranium0.0002179Highly InformativeDirect
Xenopus ANatomical entity (XAN)regenerating tissue0.0002383Highly InformativeDirect
Xenopus ANatomical entity (XAN)mesenchyme0.0002545Highly InformativeDirect
Xenopus ANatomical entity (XAN)olfactory system0.0006896Highly InformativeDirect
Xenopus ANatomical entity (XAN)ganglion0.003628Highly InformativeInherited
Xenopus DEvelopment stage (XDE)NF stage0.0183Least InformativeInherited
Xenopus DEvelopment stage (XDE)embryonic stage0.03484Least InformativeInherited
Xenopus DEvelopment stage (XDE)tailbud stage0.5319InformativeInherited
Xenopus DEvelopment stage (XDE)NF stage 400.0001082Highly InformativeDirect

Document: XA annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)antineoplastic and immunomodulating agents0Least InformativeDirect
Drugbank ATC_code (DB)immunosuppressants0.00324Moderately InformativeInherited
Drugbank ATC_code (DB)interleukin inhibitors0.02013InformativeInherited
Drugbank ATC_code (DB)rilonacept0.0000000009685Highly InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation0Moderately InformativeDirect
Biological processImmunity0.00000005847Moderately InformativeDirect
Biological processAngiogenesis0InformativeDirect
Biological processInflammatory response0InformativeDirect
Biological processInnate immunity0.0000000002954InformativeDirect
Biological processNeurogenesis0.0000229InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0Moderately InformativeDirect
Cellular componentLysosome0InformativeDirect
DiseaseProto-oncogene0.00003392Moderately InformativeDirect
DomainSignal0Least InformativeDirect
Molecular functionHeparin-binding0InformativeDirect
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationGrowth factor0InformativeDirect
Post-translational modificationCytokine0Highly InformativeDirect
Post-translational modificationMitogen0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR008996 SSF50353 Protein matches
Abstract

Human basic fibroblast growth factor (hFGF-2)1 is a globular single chain heparin-binding polypeptide synthesized by different cell types and is involved in processes associated with proliferation and differentiation of cells. The determination of the three-dimensional structure of hFGF-2 by x-ray crystallography revealed a complex all beta-sheet protein without any disulphide bond. The overall structure shows strong homology with the fold of interleukin-1 and can be described as a trigonal pyramid with three topological units consisting each of four anti-parallel beta-sheets, giving the molecules internal pseudo three-fold symmetry. Both proteins share only 10-13% sequence identity, but superposition of their carbon backbone involves 9 of the 12 beta-sheet strands, including the anti-parallel beta-sheet incorporating the N- and C-terminal regions of the molecules [PubMed10567376].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 18 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Cytokine domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 18 hidden Markov models representing the Cytokine superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · Internal database links ]