SUPERFAMILY 1.75 HMM library and genome assignments server

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Cytokine superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   beta-Trefoil [ 50352] (8)
Superfamily:   Cytokine [ 50353] (2)
Families:   Fibroblast growth factors (FGF) [ 50354] (9)
  Interleukin-1 (IL-1) [ 50362] (5)


Superfamily statistics
Genomes (144) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 2,552 3,170 61
Proteins 2,497 3,112 61


Functional annotation
General category Processes_EC
Detailed category Immune response

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process00Least InformativeDirect
Biological Process (BP)developmental process00Least InformativeDirect
Biological Process (BP)single-organism cellular process0.0000000098240.00000000000005914Least InformativeDirect
Biological Process (BP)response to stimulus0.00000000024050Least InformativeDirect
Biological Process (BP)regulation of cellular process0.45520.2892Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.1481Least InformativeInherited
Biological Process (BP)localization0.19410.03139Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.72751Least InformativeInherited
Biological Process (BP)immune system process0.00016630Moderately InformativeDirect
Biological Process (BP)signal transduction0.00024140.0000000000000161Moderately InformativeDirect
Biological Process (BP)anatomical structure morphogenesis0.0000033790.000002802Moderately InformativeDirect
Biological Process (BP)response to endogenous stimulus0.0000000000000032610Moderately InformativeDirect
Biological Process (BP)tissue development0.000000075270.000000008177Moderately InformativeDirect
Biological Process (BP)positive regulation of metabolic process0.00000000034360.00000001808Moderately InformativeDirect
Biological Process (BP)response to organic substance00.00002646Moderately InformativeDirect
Biological Process (BP)regulation of localization0.000059110.0000000000002989Moderately InformativeDirect
Biological Process (BP)positive regulation of molecular function0.00011720.0003846Moderately InformativeDirect
Biological Process (BP)organ development0.000062370.0004403Moderately InformativeDirect
Biological Process (BP)positive regulation of cellular process0.000010750.00000000006233Moderately InformativeDirect
Biological Process (BP)regulation of developmental process00Moderately InformativeDirect
Biological Process (BP)regulation of multicellular organismal process00Moderately InformativeDirect
Biological Process (BP)cellular response to chemical stimulus0.0000000022590.000000000000001938Moderately InformativeDirect
Biological Process (BP)cellular localization0.16740.8442Moderately InformativeInherited
Biological Process (BP)reproduction0.020430.001467Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.00000052740.08029Moderately InformativeInherited
Biological Process (BP)cell differentiation00.1558Moderately InformativeInherited
Biological Process (BP)regulation of catalytic activity0.99780.09586Moderately InformativeInherited
Biological Process (BP)regulation of phosphate metabolic process10.00000000000002119Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.9481Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.081090.1125Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.0017250.009939Moderately InformativeInherited
Biological Process (BP)positive regulation of response to stimulus0.82820.01242Moderately InformativeInherited
Biological Process (BP)organic substance transport0.00045180.01883Moderately InformativeInherited
Biological Process (BP)regulation of biological quality11Moderately InformativeInherited
Biological Process (BP)nervous system development10.8305Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.000059770.9202Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.68130.6613Moderately InformativeInherited
Biological Process (BP)regulation of macromolecule biosynthetic process0.000000068370.5064Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process0.00000037620.2497Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.23770.0003693Moderately InformativeInherited
Biological Process (BP)regulation of protein phosphorylation0.00000000000033730InformativeDirect
Biological Process (BP)regulation of transcription from RNA polymerase II promoter0.00000021270.0000009326InformativeDirect
Biological Process (BP)enzyme linked receptor protein signaling pathway00InformativeDirect
Biological Process (BP)response to wounding0.00042940.000000007547InformativeDirect
Biological Process (BP)positive regulation of gene expression0.0000000000000048660.000000000007613InformativeDirect
Biological Process (BP)regulation of hormone levels0.0000017050.0009653InformativeDirect
Biological Process (BP)regulation of lipid metabolic process0.0000020580.000000015InformativeDirect
Biological Process (BP)regulation of anatomical structure morphogenesis0.000005470.0001292InformativeDirect
Biological Process (BP)tube development00InformativeDirect
Biological Process (BP)growth0.0000000052360.00001566InformativeDirect
Biological Process (BP)regulation of locomotion0.000000000077610InformativeDirect
Biological Process (BP)regulation of cell proliferation00InformativeDirect
Biological Process (BP)positive regulation of nucleobase-containing compound metabolic process0.00000000010990.0000002474InformativeDirect
Biological Process (BP)positive regulation of phosphate metabolic process0.000000000000018560.00000001303InformativeDirect
Biological Process (BP)anatomical structure formation involved in morphogenesis0.00039460.0000003514InformativeDirect
Biological Process (BP)tissue morphogenesis0.0000000020280.000000000002322InformativeDirect
Biological Process (BP)positive regulation of developmental process00.000000000000003755InformativeDirect
Biological Process (BP)positive regulation of multicellular organismal process0.0000000010630InformativeDirect
Biological Process (BP)regulation of cellular component movement0.00000000002640InformativeDirect
Biological Process (BP)cellular response to endogenous stimulus0.00000051850.0000000000007309InformativeDirect
Biological Process (BP)cardiovascular system development0.00020240.000002084InformativeDirect
Biological Process (BP)sensory organ development0.041730.002668InformativeInherited
Biological Process (BP)epithelium development0.015750.03252InformativeInherited
Biological Process (BP)gland development0.0026980.001041InformativeInherited
Biological Process (BP)central nervous system development0.23970.2242InformativeInherited
Biological Process (BP)cytoplasmic transport0.0037750.001457InformativeInherited
Biological Process (BP)regulation of cell development0.62460.6428InformativeInherited
Biological Process (BP)regulation of growth0.070260.0004343InformativeInherited
Biological Process (BP)developmental process involved in reproduction0.96470.6809InformativeInherited
Biological Process (BP)positive regulation of macromolecule biosynthetic process0.00000000071920.001429InformativeInherited
Biological Process (BP)positive regulation of cellular biosynthetic process0.0000000034720.007708InformativeInherited
Biological Process (BP)protein localization to organelle0.0008510.1703InformativeInherited
Biological Process (BP)regulation of kinase activity0.69190.2972InformativeInherited
Biological Process (BP)regulation of cytokine production0.6440.02975InformativeInherited
Biological Process (BP)organ morphogenesis0.19330.03407InformativeInherited
Biological Process (BP)embryonic organ development0.028750.0001474InformativeInherited
Biological Process (BP)embryonic morphogenesis0.066390.00005564InformativeInherited
Biological Process (BP)positive regulation of signal transduction0.0022990.000000001449InformativeInherited
Biological Process (BP)secretion by cell0.0055460.1578InformativeInherited
Biological Process (BP)protein transport0.38560.1669InformativeInherited
Biological Process (BP)nitrogen compound transport0.0042570.07813InformativeInherited
Biological Process (BP)positive regulation of protein metabolic process0.1090.0004788InformativeInherited
Biological Process (BP)cellular component morphogenesis0.48450.6011InformativeInherited
Biological Process (BP)intracellular signal transduction10.207InformativeInherited
Biological Process (BP)MAPK cascade0.00091970Highly InformativeDirect
Biological Process (BP)angiogenesis0.00000060880.00000000000003788Highly InformativeDirect
Biological Process (BP)transmembrane receptor protein tyrosine kinase signaling pathway00Highly InformativeDirect
Biological Process (BP)response to heat0.00019470.000000000002256Highly InformativeDirect
Biological Process (BP)hormone transport0.0000000066930.000006866Highly InformativeDirect
Biological Process (BP)glial cell differentiation0.000094440.00000191Highly InformativeDirect
Biological Process (BP)protein import0.000029040.0000008735Highly InformativeDirect
Biological Process (BP)diencephalon development0.000004150.0000000003951Highly InformativeDirect
Biological Process (BP)respiratory tube development0.0000000000000032610Highly InformativeDirect
Biological Process (BP)positive regulation of cell migration0.000080460.00003595Highly InformativeDirect
Biological Process (BP)protein localization to nucleus0.0000059720.0000004158Highly InformativeDirect
Biological Process (BP)limb morphogenesis0.0000000049210.00000863Highly InformativeDirect
Biological Process (BP)endocrine system development0.0000015480.0000003496Highly InformativeDirect
Biological Process (BP)amide transport0.000000025730.00005547Highly InformativeDirect
Biological Process (BP)protein targeting to nucleus0.0000015440.00000006213Highly InformativeDirect
Biological Process (BP)cell fate commitment0.00000000000920.000000000191Highly InformativeDirect
Biological Process (BP)positive regulation of lipid metabolic process0.0000004040.0000000176Highly InformativeDirect
Biological Process (BP)positive regulation of transcription, DNA-dependent0.0000000028720.000284Highly InformativeDirect
Biological Process (BP)branching morphogenesis of an epithelial tube00.0000000001379Highly InformativeDirect
Biological Process (BP)stem cell development0.00010540.0000001407Highly InformativeDirect
Biological Process (BP)regulation of steroid biosynthetic process00Highly InformativeDirect
Biological Process (BP)nuclear import0.0000061890.00000007673Highly InformativeDirect
Biological Process (BP)regulation of cell division0.0000000000026240.0000007998Highly InformativeDirect
Biological Process (BP)mesenchyme development0.000025170.00000003233Highly InformativeDirect
Biological Process (BP)respiratory system development0.0000000000012950Highly InformativeDirect
Biological Process (BP)cellular response to growth factor stimulus00Highly InformativeDirect
Biological Process (BP)renal system development0.000000000000034860.0000000000009556Highly InformativeDirect
Biological Process (BP)regulation of cellular response to growth factor stimulus0.000010440.0000004685Highly InformativeDirect
Biological Process (BP)regulation of organ morphogenesis0.000000013020.0000002115Highly InformativeDirect
Biological Process (BP)regulation of striated muscle tissue development10Highly InformativeInherited
Biological Process (BP)regulation of developmental growth0.30370.05331Highly InformativeInherited
Biological Process (BP)regulation of transmembrane receptor protein serine/threonine kinase signaling pathway0.0017570.04282Highly InformativeInherited
Biological Process (BP)ear development0.0034410.000000003987Highly InformativeInherited
Biological Process (BP)embryonic organ morphogenesis0.0047430.00000241Highly InformativeInherited
Biological Process (BP)signal release0.000000073690.05729Highly InformativeInherited
Biological Process (BP)pattern specification process0.056690.1168Highly InformativeInherited
Biological Process (BP)developmental growth0.000011170.001522Highly InformativeInherited
Biological Process (BP)skeletal system development0.097130.002294Highly InformativeInherited
Biological Process (BP)connective tissue development0.11780.001287Highly InformativeInherited
Biological Process (BP)cell morphogenesis involved in differentiation0.10510.3654Highly InformativeInherited
Molecular Function (MF)binding0.0000000084110Least InformativeDirect
Molecular Function (MF)anion binding0.000000061770.8756Moderately InformativeInherited
Molecular Function (MF)receptor binding00InformativeDirect
Molecular Function (MF)carbohydrate derivative binding0.000000000000041230.000000000001599InformativeDirect
Molecular Function (MF)sulfur compound binding00.000000000000004577InformativeDirect
Molecular Function (MF)heparin binding0.000000000000011360Highly InformativeDirect
Molecular Function (MF)growth factor receptor binding00Highly InformativeDirect
Cellular Component (CC)cytoplasmic part0.1520.2645Least InformativeInherited
Cellular Component (CC)cytosol0.000081910.000000164Moderately InformativeDirect
Cellular Component (CC)extracellular region part00Moderately InformativeDirect
Cellular Component (CC)extracellular space00InformativeDirect
Cellular Component (CC)extracellular matrix0.000000029570.00000000002703InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.00000000000005914 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.2892 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 0.03139 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) signal transduction 0.0000000000000161 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.000002802 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0 Moderately Informative Direct
Biological Process (BP) tissue development 0.000000008177 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0.00000001808 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.00002646 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0.00000000000002119 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.0000000000002989 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 0.0003846 Moderately Informative Direct
Biological Process (BP) organ development 0.0004403 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.00000000006233 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.0003693 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.000000000000001938 Moderately Informative Direct
Biological Process (BP) cellular localization 0.8442 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.001467 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.01242 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.009939 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.2469 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.1558 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.09586 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.1125 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.08029 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.5432 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.01883 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.9202 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.8305 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.6613 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.5064 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.2497 Moderately Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0 Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.0000009326 Informative Direct
Biological Process (BP) apoptotic process 0.00000007169 Informative Direct
Biological Process (BP) immune response 0.000005207 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 0 Informative Direct
Biological Process (BP) response to wounding 0.000000007547 Informative Direct
Biological Process (BP) positive regulation of signal transduction 0.000000001449 Informative Direct
Biological Process (BP) regulation of intracellular protein kinase cascade 0.000000005459 Informative Direct
Biological Process (BP) positive regulation of gene expression 0.000000000007613 Informative Direct
Biological Process (BP) regulation of hormone levels 0.0009653 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 0.000000015 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.0001292 Informative Direct
Biological Process (BP) tube development 0 Informative Direct
Biological Process (BP) growth 0.00001566 Informative Direct
Biological Process (BP) regulation of growth 0.0004343 Informative Direct
Biological Process (BP) locomotion 0.0000000000006571 Informative Direct
Biological Process (BP) regulation of locomotion 0 Informative Direct
Biological Process (BP) regulation of cell proliferation 0 Informative Direct
Biological Process (BP) single-organism behavior 0.0001322 Informative Direct
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 0.0000002474 Informative Direct
Biological Process (BP) positive regulation of phosphate metabolic process 0.00000001303 Informative Direct
Biological Process (BP) embryonic organ development 0.0001474 Informative Direct
Biological Process (BP) embryonic morphogenesis 0.00005564 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.0000003514 Informative Direct
Biological Process (BP) tissue morphogenesis 0.000000000002322 Informative Direct
Biological Process (BP) regulation of cell activation 0.00007899 Informative Direct
Biological Process (BP) positive regulation of developmental process 0.000000000000003755 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0 Informative Direct
Biological Process (BP) positive regulation of protein metabolic process 0.0004788 Informative Direct
Biological Process (BP) regulation of cellular component movement 0 Informative Direct
Biological Process (BP) localization of cell 0.000000001487 Informative Direct
Biological Process (BP) cellular response to endogenous stimulus 0.0000000000007309 Informative Direct
Biological Process (BP) cardiovascular system development 0.000002084 Informative Direct
Biological Process (BP) regulation of cell cycle process 0.2509 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.9056 Informative Inherited
Biological Process (BP) cellular component movement 0.03174 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.1083 Informative Inherited
Biological Process (BP) response to hormone stimulus 1 Informative Inherited
Biological Process (BP) sensory organ development 0.002668 Informative Inherited
Biological Process (BP) epithelium development 0.03252 Informative Inherited
Biological Process (BP) gland development 0.001041 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.3562 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.001457 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.6809 Informative Inherited
Biological Process (BP) reproductive system development 0.3769 Informative Inherited
Biological Process (BP) organ morphogenesis 0.03407 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.1327 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.207 Informative Inherited
Biological Process (BP) regulation of secretion 0.2611 Informative Inherited
Biological Process (BP) negative regulation of transport 0.09336 Informative Inherited
Biological Process (BP) positive regulation of transport 0.0948 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.6154 Informative Inherited
Biological Process (BP) response to inorganic substance 0.6647 Informative Inherited
Biological Process (BP) regulation of cell development 0.6428 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.001429 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.007708 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.5242 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.06659 Informative Inherited
Biological Process (BP) response to organonitrogen compound 0.6123 Informative Inherited
Biological Process (BP) regulation of protein localization 1 Informative Inherited
Biological Process (BP) regulation of immune response 0.4191 Informative Inherited
Biological Process (BP) protein localization to organelle 0.1703 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 0.4949 Informative Inherited
Biological Process (BP) regulation of purine nucleotide metabolic process 0.001473 Informative Inherited
Biological Process (BP) regulation of nucleoside metabolic process 0.2084 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.7894 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.02975 Informative Inherited
Biological Process (BP) response to bacterium 0.003204 Informative Inherited
Biological Process (BP) response to lipid 1 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.001504 Informative Inherited
Biological Process (BP) central nervous system development 0.2242 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.4656 Informative Inherited
Biological Process (BP) leukocyte activation 1 Informative Inherited
Biological Process (BP) secretion by cell 0.1578 Informative Inherited
Biological Process (BP) protein transport 0.1669 Informative Inherited
Biological Process (BP) nitrogen compound transport 0.07813 Informative Inherited
Biological Process (BP) regulation of ion transport 0.03779 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.6011 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.2972 Informative Inherited
Biological Process (BP) MAPK cascade 0 Highly Informative Direct
Biological Process (BP) angiogenesis 0.00000000000003788 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0 Highly Informative Direct
Biological Process (BP) response to heat 0.000000000002256 Highly Informative Direct
Biological Process (BP) hormone transport 0.000006866 Highly Informative Direct
Biological Process (BP) glial cell differentiation 0.00000191 Highly Informative Direct
Biological Process (BP) regulation of striated muscle tissue development 0 Highly Informative Direct
Biological Process (BP) protein import 0.0000008735 Highly Informative Direct
Biological Process (BP) diencephalon development 0.0000000003951 Highly Informative Direct
Biological Process (BP) neural tube development 0.0006627 Highly Informative Direct
Biological Process (BP) respiratory tube development 0 Highly Informative Direct
Biological Process (BP) positive regulation of cell migration 0.00003595 Highly Informative Direct
Biological Process (BP) response to lipopolysaccharide 0.0001323 Highly Informative Direct
Biological Process (BP) regulation of mononuclear cell proliferation 0.00000000000002119 Highly Informative Direct
Biological Process (BP) protein localization to nucleus 0.0000004158 Highly Informative Direct
Biological Process (BP) limb morphogenesis 0.00000863 Highly Informative Direct
Biological Process (BP) endocrine system development 0.0000003496 Highly Informative Direct
Biological Process (BP) amide transport 0.00005547 Highly Informative Direct
Biological Process (BP) positive regulation of ion transport 0.0009152 Highly Informative Direct
Biological Process (BP) positive regulation of MAPK cascade 0.0000003851 Highly Informative Direct
Biological Process (BP) response to peptide hormone stimulus 0.000000007782 Highly Informative Direct
Biological Process (BP) ear development 0.000000003987 Highly Informative Direct
Biological Process (BP) protein targeting to nucleus 0.00000006213 Highly Informative Direct
Biological Process (BP) cell fate commitment 0.000000000191 Highly Informative Direct
Biological Process (BP) positive regulation of lipid metabolic process 0.0000000176 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-dependent 0.000284 Highly Informative Direct
Biological Process (BP) regulation of nucleocytoplasmic transport 0.00001426 Highly Informative Direct
Biological Process (BP) embryonic organ morphogenesis 0.00000241 Highly Informative Direct
Biological Process (BP) branching morphogenesis of an epithelial tube 0.0000000001379 Highly Informative Direct
Biological Process (BP) stem cell development 0.0000001407 Highly Informative Direct
Biological Process (BP) positive regulation of epithelial cell proliferation 0.0002756 Highly Informative Direct
Biological Process (BP) regulation of steroid biosynthetic process 0 Highly Informative Direct
Biological Process (BP) positive regulation of cell activation 0.0001256 Highly Informative Direct
Biological Process (BP) neuromuscular process 0.0002582 Highly Informative Direct
Biological Process (BP) regulation of striated muscle cell differentiation 0.000004227 Highly Informative Direct
Biological Process (BP) nuclear import 0.00000007673 Highly Informative Direct
Biological Process (BP) regulation of cell division 0.0000007998 Highly Informative Direct
Biological Process (BP) mesenchyme development 0.00000003233 Highly Informative Direct
Biological Process (BP) respiratory system development 0 Highly Informative Direct
Biological Process (BP) neural precursor cell proliferation 0.0006734 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 0 Highly Informative Direct
Biological Process (BP) renal system development 0.0000000000009556 Highly Informative Direct
Biological Process (BP) positive regulation of cell cycle process 0.000006682 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.0000004685 Highly Informative Direct
Biological Process (BP) cellular response to peptide 0.000000002403 Highly Informative Direct
Biological Process (BP) regulation of organ morphogenesis 0.0000002115 Highly Informative Direct
Biological Process (BP) regulation of G1/S transition of mitotic cell cycle 0.00000000318 Highly Informative Direct
Biological Process (BP) developmental growth 0.001522 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.05331 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.2988 Highly Informative Inherited
Biological Process (BP) chemotaxis 0.304 Highly Informative Inherited
Biological Process (BP) regulation of hormone secretion 0.1276 Highly Informative Inherited
Biological Process (BP) negative regulation of secretion 0.001852 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.05396 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.003749 Highly Informative Inherited
Biological Process (BP) regulation of mitosis 0.01492 Highly Informative Inherited
Biological Process (BP) regulation of angiogenesis 0.001114 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 0.0301 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0.001133 Highly Informative Inherited
Biological Process (BP) regulation of intracellular protein transport 0.003306 Highly Informative Inherited
Biological Process (BP) regulation of protein localization to nucleus 0.006867 Highly Informative Inherited
Biological Process (BP) immune response-regulating cell surface receptor signaling pathway 0.005631 Highly Informative Inherited
Biological Process (BP) artery morphogenesis 0.1424 Highly Informative Inherited
Biological Process (BP) positive regulation of leukocyte proliferation 0.2953 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.04282 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.05379 Highly Informative Inherited
Biological Process (BP) positive regulation of protein kinase activity 0.01516 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.1168 Highly Informative Inherited
Biological Process (BP) signal release 0.05729 Highly Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 0.2189 Highly Informative Inherited
Biological Process (BP) telencephalon development 0.01199 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.3123 Highly Informative Inherited
Biological Process (BP) adult behavior 0.1127 Highly Informative Inherited
Biological Process (BP) heart morphogenesis 0.03774 Highly Informative Inherited
Biological Process (BP) skeletal system development 0.002294 Highly Informative Inherited
Biological Process (BP) connective tissue development 0.001287 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 0.9884 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.3654 Highly Informative Inherited
Biological Process (BP) ossification 0.002379 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) cation binding 0.7839 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.8756 Moderately Informative Inherited
Molecular Function (MF) receptor binding 0 Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.000000000001599 Informative Direct
Molecular Function (MF) sulfur compound binding 0.000000000000004577 Informative Direct
Molecular Function (MF) copper ion binding 0 Highly Informative Direct
Molecular Function (MF) heparin binding 0 Highly Informative Direct
Molecular Function (MF) growth factor receptor binding 0 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0.2645 Least Informative Inherited
Cellular Component (CC) cytosol 0.000000164 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) extracellular space 0 Informative Direct
Cellular Component (CC) cell surface 0.00002655 Informative Direct
Cellular Component (CC) extracellular matrix 0.00000000002703 Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.1932Least InformativeInherited
Disease Ontology (DO)organ system cancer0.213Least InformativeInherited
Disease Ontology (DO)skin disease0.0003372Moderately InformativeDirect
Disease Ontology (DO)endocrine system disease0.0006633Moderately InformativeDirect
Disease Ontology (DO)mouth disease0.005351Moderately InformativeInherited
Disease Ontology (DO)obstructive lung disease0.006559Moderately InformativeInherited
Disease Ontology (DO)connective tissue disease0.0441Moderately InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.1949Moderately InformativeInherited
Disease Ontology (DO)hematologic cancer0.2209Moderately InformativeInherited
Disease Ontology (DO)chronic obstructive pulmonary disease0.0002125InformativeDirect
Disease Ontology (DO)hemorrhagic disease0.0004843InformativeDirect
Disease Ontology (DO)physical disorder0.0005132InformativeDirect
Disease Ontology (DO)malaria0.001154InformativeInherited
Disease Ontology (DO)lymphoma0.007268InformativeInherited
Disease Ontology (DO)arthropathy0.01089InformativeInherited
Disease Ontology (DO)female reproductive system disease0.179InformativeInherited
Disease Ontology (DO)purpura0.00002904Highly InformativeDirect
Disease Ontology (DO)spondylitis0.0003888Highly InformativeDirect
Disease Ontology (DO)Hodgkin's lymphoma0.0004843Highly InformativeDirect
Disease Ontology (DO)endometriosis0.0005826Highly InformativeDirect
Disease Ontology (DO)Behcet's disease0.0005953Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of head and neck0Least InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.478Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.5715Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis1Least InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.05596Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.2002Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.2919Moderately InformativeInherited
Mammalian Phenotype (MP)renal/urinary system phenotype0.457Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin secretion0.4518InformativeInherited
Mammalian Phenotype (MP)abnormal ureteric bud morphology0.0006993Highly InformativeDirect
Mammalian Phenotype (MP)abnormal interleukin-1 beta secretion0.0009076Highly InformativeDirect
Mammalian Phenotype (MP)abnormal hair growth0.03223Highly InformativeInherited
Mammalian Phenotype (MP)abnormal skin physiology0.05839Highly InformativeInherited

Document: MP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0Least InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)cell0Least InformativeDirect
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)late embryo0Moderately InformativeDirect
Fly Anatomy (FA)developing material anatomical entity0Moderately InformativeDirect
Fly Anatomy (FA)extended germ band embryo0InformativeDirect
Fly Anatomy (FA)dorsal closure embryo0InformativeDirect
Fly Anatomy (FA)primordium0InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)multi-tissue structure0Least InformativeDirect
Zebrafish Anatomy (ZA)nervous system0.1095Least InformativeInherited
Zebrafish Anatomy (ZA)paired fin0.0002051Moderately InformativeDirect
Zebrafish Anatomy (ZA)peripheral nervous system0.000329InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0.1247Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.2567Least InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.0000004986Moderately InformativeDirect
Xenopus ANatomical entity (XAN)visual system0.003173Moderately InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.003503Moderately InformativeInherited
Xenopus ANatomical entity (XAN)surface structure0.02111Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.461Moderately InformativeInherited
Xenopus ANatomical entity (XAN)pharyngeal region0.0000000001134InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0.000003535InformativeDirect
Xenopus ANatomical entity (XAN)vestibuloauditory system0.000004227InformativeDirect
Xenopus ANatomical entity (XAN)cranial placode0.00002876InformativeDirect
Xenopus ANatomical entity (XAN)notochord0.00006686InformativeDirect
Xenopus ANatomical entity (XAN)anatomical direction0.0001141InformativeDirect
Xenopus ANatomical entity (XAN)mesenchyme0.0004799InformativeDirect
Xenopus ANatomical entity (XAN)neural plate0.01289InformativeInherited
Xenopus ANatomical entity (XAN)primordium0.01773InformativeInherited
Xenopus ANatomical entity (XAN)tail0.1973InformativeInherited
Xenopus ANatomical entity (XAN)limb0.8308InformativeInherited
Xenopus ANatomical entity (XAN)cranial neural crest0.0000003366Highly InformativeDirect
Xenopus ANatomical entity (XAN)appendage0.000006635Highly InformativeDirect
Xenopus ANatomical entity (XAN)chordoneural hinge0.000007536Highly InformativeDirect
Xenopus ANatomical entity (XAN)limb bud0.00002182Highly InformativeDirect
Xenopus ANatomical entity (XAN)optic vesicle0.00006387Highly InformativeDirect
Xenopus ANatomical entity (XAN)intersomitic region0.0002073Highly InformativeDirect
Xenopus ANatomical entity (XAN)stomodeal-hypophyseal primordium0.0005273Highly InformativeDirect
Xenopus ANatomical entity (XAN)lens0.0008938Highly InformativeDirect
Xenopus ANatomical entity (XAN)involuted dorsal mesoderm0.0009695Highly InformativeDirect
Xenopus ANatomical entity (XAN)midbrain-hindbrain boundary0.0009755Highly InformativeDirect

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation0Moderately InformativeDirect
Biological processAngiogenesis0InformativeDirect
Biological processInflammatory response0InformativeDirect
Biological processNeurogenesis0.00001393InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
DiseaseProto-oncogene0.00002483Moderately InformativeDirect
DomainSignal0Least InformativeDirect
Molecular functionHeparin-binding0InformativeDirect
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationGrowth factor0InformativeDirect
Post-translational modificationCytokine0Highly InformativeDirect
Post-translational modificationMitogen0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR008996 SSF50353 Protein matches
Abstract

Human basic fibroblast growth factor (hFGF-2)1 is a globular single chain heparin-binding polypeptide synthesized by different cell types and is involved in processes associated with proliferation and differentiation of cells. The determination of the three-dimensional structure of hFGF-2 by x-ray crystallography revealed a complex all beta-sheet protein without any disulphide bond. The overall structure shows strong homology with the fold of interleukin-1 and can be described as a trigonal pyramid with three topological units consisting each of four anti-parallel beta-sheets, giving the molecules internal pseudo three-fold symmetry. Both proteins share only 10-13% sequence identity, but superposition of their carbon backbone involves 9 of the 12 beta-sheet strands, including the anti-parallel beta-sheet incorporating the N- and C-terminal regions of the molecules [PubMed10567376].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 18 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Cytokine domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 18 hidden Markov models representing the Cytokine superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]