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EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Elongation factor/aminomethyltransferase common domain [ 50464] (2)
Superfamily:   EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain [ 50465]
Families:   EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain [ 50466] (6)


Superfamily statistics
Genomes (3,259) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 10,771 60,771 24
Proteins 10,757 60,725 24


Functional annotation
General category Information
Detailed category Translation

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biosynthetic process 0 Least Informative Direct
Biological Process (BP) cellular nitrogen compound metabolic process 0 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0.000000000000009084 Least Informative Direct
Biological Process (BP) macromolecule metabolic process 0.0000003993 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.08447 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.01998 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) amide biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) peptide metabolic process 0 Moderately Informative Direct
Biological Process (BP) gene expression 0 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 0.0001752 Moderately Informative Direct
Biological Process (BP) tissue development 0.4714 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.9067 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.9509 Moderately Informative Inherited
Biological Process (BP) reproduction 0.2851 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.9862 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.7067 Moderately Informative Inherited
Biological Process (BP) purine-containing compound metabolic process 0.05918 Moderately Informative Inherited
Biological Process (BP) nucleoside phosphate metabolic process 0.001798 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.6974 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.3874 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.258 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) growth 0.000001554 Informative Direct
Biological Process (BP) glycosyl compound metabolic process 0.000004531 Informative Direct
Biological Process (BP) reproductive system development 0.0004668 Informative Direct
Biological Process (BP) nucleobase-containing compound catabolic process 0.0008009 Informative Direct
Biological Process (BP) post-embryonic development 0.002831 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.02823 Informative Inherited
Biological Process (BP) cell development 0.386 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.01797 Informative Inherited
Biological Process (BP) single organism reproductive process 0.1089 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.03186 Informative Inherited
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 0.3304 Informative Inherited
Biological Process (BP) regulation of catabolic process 0.002196 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 0.693 Informative Inherited
Biological Process (BP) negative regulation of gene expression 0.5042 Informative Inherited
Biological Process (BP) trichome differentiation 0.00000000001569 Highly Informative Direct
Biological Process (BP) translational initiation 0.0000000009316 Highly Informative Direct
Biological Process (BP) cellular component disassembly 0.0000000009684 Highly Informative Direct
Biological Process (BP) purine ribonucleoside metabolic process 0.00000001658 Highly Informative Direct
Biological Process (BP) seed development 0.00000002173 Highly Informative Direct
Biological Process (BP) cell growth 0.0000003015 Highly Informative Direct
Biological Process (BP) developmental growth involved in morphogenesis 0.000001279 Highly Informative Direct
Biological Process (BP) positive regulation of cellular catabolic process 0.00001844 Highly Informative Direct
Biological Process (BP) RNA catabolic process 0.00006389 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 0.00216 Highly Informative Inherited
Molecular Function (MF) binding 0.000000000000001615 Least Informative Direct
Molecular Function (MF) hydrolase activity 0.00001201 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.000000000000007771 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.000000000001237 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0.000000001135 Moderately Informative Direct
Molecular Function (MF) nucleic acid binding 0.0004168 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.3996 Moderately Informative Inherited
Molecular Function (MF) purine nucleotide binding 0 Informative Direct
Molecular Function (MF) ribonucleotide binding 0 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0 Informative Direct
Molecular Function (MF) RNA binding 0 Informative Direct
Molecular Function (MF) nucleotidyltransferase activity 0.0003971 Informative Direct
Molecular Function (MF) purine nucleoside binding 0 Highly Informative Direct
Molecular Function (MF) translation factor activity, RNA binding 0 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0.0000000008725 Least Informative Direct
Cellular Component (CC) protein complex 0.0471 Least Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Nucleotidyltransferases0Least InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep1Moderately InformativeInherited
Enzyme Commission (EC)Sulfate adenylyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Adenylyl-sulfate kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processProtein biosynthesis0InformativeDirect
Biological processNonsense-mediated mRNA decay0.00009831Highly InformativeDirect
Biological processNodulation0.0001137Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionGTP-binding0InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationNucleotidyltransferase0Moderately InformativeDirect
Post-translational modificationInitiation factor0InformativeDirect
Post-translational modificationElongation factor0Highly InformativeDirect
Post-translational modificationMethylation0.0000008486Moderately InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR009001 SSF50465 Protein matches
Abstract

A beta barrel of circularly permuted topology is found in the C-terminus of many translation elongation and initiation factors. This domain is found in the elongation factors EF1A (or EF-Tu) of both eukaryotes and prokaryotes, which functions to recognize and transport aminoacyl-tRNA to the acceptor (A) site of the ribosome during the elongation process [PubMed10715211, PubMed11106763]. This domain is also found in the initiation factor IF2 gamma subunit of eukaryotes [PubMed11927566], which functions to transport the initiator methionyl-tRNA to the ribosome. The C-terminal extension of mitochondrial EF1A (or EF-Tu) has structural similarities with DNA recognising zinc fingers, suggesting that the extension may be involved in recognition of RNA.

More information about EF1A proteins can be found at Protein of the Month: Elongation Factors.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 11 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 11 hidden Markov models representing the EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]