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Trypsin-like serine proteases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Trypsin-like serine proteases [ 50493]
Superfamily:   Trypsin-like serine proteases [ 50494] (4)
Families:   Prokaryotic proteases [ 50495] (15)
  Eukaryotic proteases [ 50514] (47)
  Viral proteases [ 50596] (4)
  Viral cysteine protease of trypsin fold [ 50603] (3)


Superfamily statistics
Genomes (3,102) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 36,499 204,311 291
Proteins 34,150 193,026 291


Functional annotation
General category Processes_IC
Detailed category Proteases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process0.0000000000000031440.000004821Least InformativeDirect
Biological Process (BP)macromolecule metabolic process0.0000000000000016250Least InformativeDirect
Biological Process (BP)primary metabolic process0.000036630.0000001141Least InformativeDirect
Biological Process (BP)biological regulation0.00000062660Least InformativeDirect
Biological Process (BP)organonitrogen compound metabolic process0.0000000000036490Least InformativeDirect
Biological Process (BP)single-organism metabolic process11Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.81611Least InformativeInherited
Biological Process (BP)single-organism cellular process0.82531Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process11Least InformativeInherited
Biological Process (BP)heterocycle metabolic process11Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process11Least InformativeInherited
Biological Process (BP)response to stimulus0.10510.01877Least InformativeInherited
Biological Process (BP)immune system process0.00022220.0001651Moderately InformativeDirect
Biological Process (BP)defense response0.00026540.0005494Moderately InformativeDirect
Biological Process (BP)regulation of response to stimulus0.000075460.0000000467Moderately InformativeDirect
Biological Process (BP)multi-organism process0.000038730Moderately InformativeDirect
Biological Process (BP)regulation of developmental process0.21460.5328Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.0010150.0000009732Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.019630.0003867Moderately InformativeInherited
Biological Process (BP)response to biotic stimulus0.014320.000002037Moderately InformativeInherited
Biological Process (BP)gene expression0.60730.7148Moderately InformativeInherited
Biological Process (BP)regulation of cell communication0.68641Moderately InformativeInherited
Biological Process (BP)regulation of signaling0.99171Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.0012290.0000000000007828Moderately InformativeInherited
Biological Process (BP)reproduction0.000000034010.001961Moderately InformativeInherited
Biological Process (BP)cell differentiation0.013371Moderately InformativeInherited
Biological Process (BP)tissue development0.20651Moderately InformativeInherited
Biological Process (BP)single-organism catabolic process0.64021Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.32891Moderately InformativeInherited
Biological Process (BP)animal organ development0.10970.8117Moderately InformativeInherited
Biological Process (BP)response to external stimulus0.0083420.00112Moderately InformativeInherited
Biological Process (BP)single-organism transport0.89680.552Moderately InformativeInherited
Biological Process (BP)proteolysis00InformativeDirect
Biological Process (BP)immune response0.0000097210.000000000005637InformativeDirect
Biological Process (BP)regulation of response to external stimulus0.000021950InformativeDirect
Biological Process (BP)negative regulation of multicellular organismal process0.000037790InformativeDirect
Biological Process (BP)positive regulation of developmental process0.70381InformativeInherited
Biological Process (BP)regulation of cell differentiation0.0041490.00002733InformativeInherited
Biological Process (BP)epithelium development0.64461InformativeInherited
Biological Process (BP)cell death0.000000028650.001505InformativeInherited
Biological Process (BP)interspecies interaction between organisms0.58740InformativeInherited
Biological Process (BP)defense response to other organism0.27151InformativeInherited
Biological Process (BP)system process0.58240.06518InformativeInherited
Biological Process (BP)positive regulation of signal transduction0.35011InformativeInherited
Biological Process (BP)cell activation0.00026180.1016InformativeInherited
Biological Process (BP)multi-organism reproductive process0.04041InformativeInherited
Biological Process (BP)negative regulation of response to stimulus0.0010780.08473InformativeInherited
Biological Process (BP)anatomical structure formation involved in morphogenesis0.15581InformativeInherited
Biological Process (BP)generation of neurons11InformativeInherited
Biological Process (BP)central nervous system development0.16391InformativeInherited
Biological Process (BP)single organism reproductive process0.048010.3505InformativeInherited
Biological Process (BP)tetrapyrrole metabolic process0.042830.05634InformativeInherited
Biological Process (BP)behavior0.0073760.0003023InformativeInherited
Biological Process (BP)response to extracellular stimulus0.13541InformativeInherited
Biological Process (BP)multicellular organism reproduction0.0046520.003868InformativeInherited
Biological Process (BP)vesicle-mediated transport0.11330.019InformativeInherited
Biological Process (BP)secretion by cell0.0078060.0002446InformativeInherited
Biological Process (BP)immune effector process0.017960.00000034InformativeInherited
Biological Process (BP)neutrophil mediated immunity0.00000016310.000002743Highly InformativeDirect
Biological Process (BP)digestion0.00095510.0004481Highly InformativeDirect
Biological Process (BP)cobalamin metabolic process0.00001210.000006512Highly InformativeDirect
Biological Process (BP)fertilization0.00000013030.0000000006536Highly InformativeDirect
Biological Process (BP)cellular component disassembly0.00000000017640.000000000000001925Highly InformativeDirect
Biological Process (BP)extracellular matrix organization0.00000000000001780.000000000000007296Highly InformativeDirect
Biological Process (BP)negative regulation of response to external stimulus0.000017750.0000000005497Highly InformativeDirect
Biological Process (BP)multicellular organism metabolic process0.0000000072440.000008143Highly InformativeDirect
Biological Process (BP)negative regulation of coagulation0.00000019870Highly InformativeDirect
Biological Process (BP)protein maturation0.00000000014870Highly InformativeDirect
Biological Process (BP)interaction with symbiont0.00012280.00003295Highly InformativeDirect
Biological Process (BP)negative regulation of hemostasis0.0000086710Highly InformativeDirect
Biological Process (BP)regulation of response to wounding0.00019970Highly InformativeDirect
Biological Process (BP)positive regulation of cell development0.14420.06597Highly InformativeInherited
Biological Process (BP)epithelial cell differentiation0.0038380.3695Highly InformativeInherited
Biological Process (BP)modification of morphology or physiology of other organism involved in symbiotic interaction0.0013220Highly InformativeInherited
Biological Process (BP)killing of cells of other organism0.63290.3404Highly InformativeInherited
Biological Process (BP)single-organism behavior0.027050.1174Highly InformativeInherited
Biological Process (BP)nervous system process0.96260.02372Highly InformativeInherited
Biological Process (BP)response to nutrient levels0.0025350.09767Highly InformativeInherited
Biological Process (BP)multi-multicellular organism process0.0054430.0000001763Highly InformativeInherited
Biological Process (BP)granulocyte activation0.35250.1485Highly InformativeInherited
Biological Process (BP)myeloid cell activation involved in immune response0.36150.04391Highly InformativeInherited
Biological Process (BP)regulation of blood pressure0.00040920.05091Highly InformativeInherited
Molecular Function (MF)hydrolase activity00Least InformativeDirect
Molecular Function (MF)binding0.61891Least InformativeInherited
Molecular Function (MF)anion binding0.36191Moderately InformativeInherited
Molecular Function (MF)carbohydrate derivative binding0.041960.9589Moderately InformativeInherited
Molecular Function (MF)metal ion binding0.54090.1218Moderately InformativeInherited
Molecular Function (MF)sulfur compound binding0.00000017940.0003645InformativeDirect
Molecular Function (MF)peptidase activity, acting on L-amino acid peptides0.33960.5504InformativeInherited
Molecular Function (MF)calcium ion binding0.00067080.000000008675Highly InformativeDirect
Molecular Function (MF)heparin binding0.0000000010940.000001342Highly InformativeDirect
Molecular Function (MF)serine hydrolase activity00Highly InformativeDirect
Cellular Component (CC)intracellular organelle part11Least InformativeInherited
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)endomembrane system0.000002850.0005412Moderately InformativeDirect
Cellular Component (CC)vesicle0.0000000014990.0000001012Moderately InformativeDirect
Cellular Component (CC)extracellular region part00Moderately InformativeDirect
Cellular Component (CC)intracellular organelle lumen0.70751Moderately InformativeInherited
Cellular Component (CC)vacuole0.0000025280.01507Moderately InformativeInherited
Cellular Component (CC)secretory granule0.000000000000075970.00000000000000156InformativeDirect
Cellular Component (CC)cytoplasmic vesicle part0.00018330.007038InformativeInherited
Cellular Component (CC)vacuolar part0.00015860.01767InformativeInherited
Cellular Component (CC)lytic vacuole0.0000000054310.1724InformativeInherited
Cellular Component (CC)vacuolar lumen0.00000000053190.0000014Highly InformativeDirect
Cellular Component (CC)cytoplasmic vesicle lumen0.0000000016320.00000007027Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0.000004821 Least Informative Direct
Biological Process (BP) macromolecule metabolic process 0 Least Informative Direct
Biological Process (BP) primary metabolic process 0.0000001141 Least Informative Direct
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.01877 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) immune system process 0.0001651 Moderately Informative Direct
Biological Process (BP) defense response 0.0005494 Moderately Informative Direct
Biological Process (BP) response to biotic stimulus 0.000002037 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 0.0000002921 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0.00000266 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.0000000000007828 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0.0000000467 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.0000009732 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0 Moderately Informative Direct
Biological Process (BP) multi-organism process 0 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.0003867 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 0.00000003639 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.5328 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.01705 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.00112 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) animal organ development 0.8117 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) peptide metabolic process 0.9222 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) ion transport 0.917 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.001492 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.9059 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) single organism signaling 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.001961 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.552 Moderately Informative Inherited
Biological Process (BP) gene expression 0.7148 Moderately Informative Inherited
Biological Process (BP) immune effector process 0.00000034 Informative Direct
Biological Process (BP) proteolysis 0 Informative Direct
Biological Process (BP) immune response 0.000000000005637 Informative Direct
Biological Process (BP) behavior 0.0003023 Informative Direct
Biological Process (BP) response to wounding 0 Informative Direct
Biological Process (BP) regulation of catabolic process 0 Informative Direct
Biological Process (BP) posttranscriptional regulation of gene expression 0 Informative Direct
Biological Process (BP) negative regulation of gene expression 0.00000000000008258 Informative Direct
Biological Process (BP) regulation of response to external stimulus 0 Informative Direct
Biological Process (BP) secretion by cell 0.0002446 Informative Direct
Biological Process (BP) regulation of cellular amide metabolic process 0 Informative Direct
Biological Process (BP) regulation of cell proliferation 0.00000004636 Informative Direct
Biological Process (BP) negative regulation of molecular function 0 Informative Direct
Biological Process (BP) interspecies interaction between organisms 0 Informative Direct
Biological Process (BP) regulation of cell differentiation 0.00002733 Informative Direct
Biological Process (BP) positive regulation of phosphate metabolic process 0.00006695 Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0 Informative Direct
Biological Process (BP) regulation of cellular localization 0.00000000000002102 Informative Direct
Biological Process (BP) regulation of hormone levels 0.3861 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) positive regulation of developmental process 1 Informative Inherited
Biological Process (BP) transmembrane transport 0.06686 Informative Inherited
Biological Process (BP) animal organ morphogenesis 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.9265 Informative Inherited
Biological Process (BP) metal ion transport 0.01683 Informative Inherited
Biological Process (BP) cell death 0.001505 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) regulation of immune response 0.0142 Informative Inherited
Biological Process (BP) multi-organism reproductive process 1 Informative Inherited
Biological Process (BP) regulation of defense response 0.3828 Informative Inherited
Biological Process (BP) defense response to other organism 1 Informative Inherited
Biological Process (BP) system process 0.06518 Informative Inherited
Biological Process (BP) response to bacterium 0.208 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) embryo development 1 Informative Inherited
Biological Process (BP) cell activation 0.1016 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.08473 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 1 Informative Inherited
Biological Process (BP) regulation of growth 0.8364 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) central nervous system development 1 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 1 Informative Inherited
Biological Process (BP) positive regulation of gene expression 0.6733 Informative Inherited
Biological Process (BP) regulation of proteolysis 0.1905 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 0.0289 Informative Inherited
Biological Process (BP) tetrapyrrole metabolic process 0.05634 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 1 Informative Inherited
Biological Process (BP) response to extracellular stimulus 1 Informative Inherited
Biological Process (BP) single organism reproductive process 0.3505 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.003868 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.4009 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.019 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.3769 Informative Inherited
Biological Process (BP) regulation of protein modification process 1 Informative Inherited
Biological Process (BP) regulation of phosphorylation 0.7007 Informative Inherited
Biological Process (BP) neutrophil mediated immunity 0.000002743 Highly Informative Direct
Biological Process (BP) regulation of humoral immune response 0.0001721 Highly Informative Direct
Biological Process (BP) digestion 0.0004481 Highly Informative Direct
Biological Process (BP) regulation of cell shape 0.0008387 Highly Informative Direct
Biological Process (BP) cobalamin metabolic process 0.000006512 Highly Informative Direct
Biological Process (BP) fertilization 0.0000000006536 Highly Informative Direct
Biological Process (BP) response to mechanical stimulus 0.0001626 Highly Informative Direct
Biological Process (BP) regulation of autophagy 0 Highly Informative Direct
Biological Process (BP) viral process 0.000000000001711 Highly Informative Direct
Biological Process (BP) cellular component disassembly 0.000000000000001925 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0.000000000000007296 Highly Informative Direct
Biological Process (BP) positive regulation of cellular catabolic process 0 Highly Informative Direct
Biological Process (BP) negative regulation of defense response 0.00000009812 Highly Informative Direct
Biological Process (BP) negative regulation of response to external stimulus 0.0000000005497 Highly Informative Direct
Biological Process (BP) carbohydrate homeostasis 0.0001921 Highly Informative Direct
Biological Process (BP) wound healing 0.000008313 Highly Informative Direct
Biological Process (BP) multicellular organism metabolic process 0.000008143 Highly Informative Direct
Biological Process (BP) multi-multicellular organism process 0.0000001763 Highly Informative Direct
Biological Process (BP) coagulation 0 Highly Informative Direct
Biological Process (BP) negative regulation of coagulation 0 Highly Informative Direct
Biological Process (BP) defense response to Gram-positive bacterium 0.0002198 Highly Informative Direct
Biological Process (BP) protein maturation 0 Highly Informative Direct
Biological Process (BP) interaction with symbiont 0.00003295 Highly Informative Direct
Biological Process (BP) modification of morphology or physiology of other organism involved in symbiotic interaction 0 Highly Informative Direct
Biological Process (BP) regulation of protein processing 0.0000000000006496 Highly Informative Direct
Biological Process (BP) inorganic cation transmembrane transport 0.00003723 Highly Informative Direct
Biological Process (BP) negative regulation of hemostasis 0 Highly Informative Direct
Biological Process (BP) regulation of response to wounding 0 Highly Informative Direct
Biological Process (BP) regulation of epithelial cell proliferation 0.2532 Highly Informative Inherited
Biological Process (BP) positive regulation of cell development 0.06597 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.1946 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.6787 Highly Informative Inherited
Biological Process (BP) killing of cells of other organism 0.3404 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 0.107 Highly Informative Inherited
Biological Process (BP) regulation of G-protein coupled receptor protein signaling pathway 0.05439 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.01762 Highly Informative Inherited
Biological Process (BP) regulation of viral process 0.2201 Highly Informative Inherited
Biological Process (BP) embryonic organ development 0.1066 Highly Informative Inherited
Biological Process (BP) sensory organ morphogenesis 0.05159 Highly Informative Inherited
Biological Process (BP) positive regulation of nucleotide metabolic process 0.002333 Highly Informative Inherited
Biological Process (BP) regulation of cyclic nucleotide metabolic process 0.001274 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.3765 Highly Informative Inherited
Biological Process (BP) regulation of cell growth 0.002158 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.3625 Highly Informative Inherited
Biological Process (BP) positive regulation of proteolysis 0.04763 Highly Informative Inherited
Biological Process (BP) epithelial cell differentiation 0.3695 Highly Informative Inherited
Biological Process (BP) single-organism behavior 0.1174 Highly Informative Inherited
Biological Process (BP) nervous system process 0.02372 Highly Informative Inherited
Biological Process (BP) hemostasis 0.005079 Highly Informative Inherited
Biological Process (BP) response to nutrient levels 0.09767 Highly Informative Inherited
Biological Process (BP) granulocyte activation 0.1485 Highly Informative Inherited
Biological Process (BP) myeloid cell activation involved in immune response 0.04391 Highly Informative Inherited
Biological Process (BP) regulation of production of molecular mediator of immune response 0.9493 Highly Informative Inherited
Biological Process (BP) positive regulation of immune effector process 0.9123 Highly Informative Inherited
Biological Process (BP) positive regulation of response to external stimulus 0.3817 Highly Informative Inherited
Biological Process (BP) regulation of blood pressure 0.05091 Highly Informative Inherited
Biological Process (BP) innate immune response 0.007273 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) molecular function regulator 1 Moderately Informative Inherited
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 0.9589 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 1 Moderately Informative Inherited
Molecular Function (MF) metal ion binding 0.1218 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) sulfur compound binding 0.0003645 Informative Direct
Molecular Function (MF) nucleotidyltransferase activity 0.4995 Informative Inherited
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 1 Informative Inherited
Molecular Function (MF) passive transmembrane transporter activity 0.09061 Informative Inherited
Molecular Function (MF) metal ion transmembrane transporter activity 0.0423 Informative Inherited
Molecular Function (MF) monovalent inorganic cation transmembrane transporter activity 0.009578 Informative Inherited
Molecular Function (MF) peptidase activity, acting on L-amino acid peptides 0.5504 Informative Inherited
Molecular Function (MF) calcium ion binding 0.000000008675 Highly Informative Direct
Molecular Function (MF) drug binding 0.0007985 Highly Informative Direct
Molecular Function (MF) heparin binding 0.000001342 Highly Informative Direct
Molecular Function (MF) serine hydrolase activity 0 Highly Informative Direct
Molecular Function (MF) monosaccharide binding 0.000005104 Highly Informative Direct
Molecular Function (MF) RNA polymerase activity 0.0006872 Highly Informative Direct
Molecular Function (MF) ion channel activity 0.04016 Highly Informative Inherited
Molecular Function (MF) exopeptidase activity 1 Highly Informative Inherited
Molecular Function (MF) gated channel activity 0.008911 Highly Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) endomembrane system 0.0005412 Moderately Informative Direct
Cellular Component (CC) vesicle 0.0000001012 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) vacuole 0.01507 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) extracellular space 0.000000344 Informative Direct
Cellular Component (CC) secretory granule 0.00000000000000156 Informative Direct
Cellular Component (CC) extracellular organelle 0.00000000006355 Informative Direct
Cellular Component (CC) cytoplasmic vesicle part 0.007038 Informative Inherited
Cellular Component (CC) nuclear envelope 0.002345 Informative Inherited
Cellular Component (CC) Golgi apparatus 0.3139 Informative Inherited
Cellular Component (CC) vacuolar part 0.01767 Informative Inherited
Cellular Component (CC) lytic vacuole 0.1724 Informative Inherited
Cellular Component (CC) acrosomal vesicle 0.0002635 Highly Informative Direct
Cellular Component (CC) vacuolar lumen 0.0000014 Highly Informative Direct
Cellular Component (CC) nuclear membrane 0.000001141 Highly Informative Direct
Cellular Component (CC) cytoplasmic vesicle lumen 0.00000007027 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Nucleotidyltransferases0Least InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.2689Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Least InformativeInherited
Enzyme Commission (EC)In phosphorous-containing anhydrides0Moderately InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0Moderately InformativeDirect
Enzyme Commission (EC)Cysteine endopeptidases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an0.000000001469Moderately InformativeDirect
Enzyme Commission (EC)Omega peptidases1Moderately InformativeInherited
Enzyme Commission (EC)Methyltransferases0.3112Moderately InformativeInherited
Enzyme Commission (EC)mRNA (nucleoside-2'-O-)-methyltransferase0InformativeDirect
Enzyme Commission (EC)RNA-directed RNA polymerase0InformativeDirect
Enzyme Commission (EC)mRNA (guanine-N(7)-)-methyltransferase0InformativeDirect
Enzyme Commission (EC)Nucleoside-triphosphatase0InformativeDirect
Enzyme Commission (EC)Flavivirin0.000000000001561InformativeDirect
Enzyme Commission (EC)SARS coronavirus main proteinase0.0000000476InformativeDirect
Enzyme Commission (EC)Picornain 3C0.00000000000001101Highly InformativeDirect
Enzyme Commission (EC)Hepacivirin0.000000000468Highly InformativeDirect
Enzyme Commission (EC)Togavirin0.000000008498Highly InformativeDirect
Enzyme Commission (EC)Picornain 2A0.00000001621Highly InformativeDirect
Enzyme Commission (EC)Nuclear-inclusion-a endopeptidase0.0000000476Highly InformativeDirect
Enzyme Commission (EC)Coagulation factor Xa0.0000008542Highly InformativeDirect
Enzyme Commission (EC)Calicivirin0.00002318Highly InformativeDirect
Enzyme Commission (EC)Helper-component proteinase0.0000507Highly InformativeDirect
Enzyme Commission (EC)Coagulation factor IXa0.00008367Highly InformativeDirect
Enzyme Commission (EC)Plasmin0.0001015Highly InformativeDirect
Enzyme Commission (EC)Protein C (activated)0.0001485Highly InformativeDirect
Enzyme Commission (EC)T-plasminogen activator0.0002633Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.3112Least InformativeInherited
Biological processImmunity0Moderately InformativeDirect
Biological processApoptosis0Moderately InformativeDirect
Biological processIon transport0Moderately InformativeDirect
Biological processHost-virus interaction0Moderately InformativeDirect
Biological processUbl conjugation pathway0.00000000000002551Moderately InformativeDirect
Biological processVirulence0.0007707Moderately InformativeDirect
Biological processEukaryotic host gene expression shutoff by virus0InformativeDirect
Biological processVirus entry into host cell0InformativeDirect
Biological processHemostasis0InformativeDirect
Biological processViral RNA replication0InformativeDirect
Biological processViral immunoevasion0InformativeDirect
Biological processmRNA processing0.00000000000000168InformativeDirect
Biological processCytolysis0.0000000005851InformativeDirect
Biological processDNA replication0.0000002054InformativeDirect
Biological processInnate immunity0.0005043InformativeDirect
Biological processAcute phase0Highly InformativeDirect
Biological processFusion of virus membrane with host endosomal membrane0Highly InformativeDirect
Biological processModulation of host ubiquitin pathway by viral deubiquitinase0Highly InformativeDirect
Biological processActivation of host autophagy by virus0Highly InformativeDirect
Biological processmRNA capping0Highly InformativeDirect
Biological processComplement pathway0.00000000000002254Highly InformativeDirect
Biological processInhibition of host NF-kappa-B by virus0.0000000000001243Highly InformativeDirect
Biological processInhibition of host ISG15 by virus0.00000000008816Highly InformativeDirect
Biological processComplement alternate pathway0.000008306Highly InformativeDirect
Biological processDecay of host mRNAs by virus0.00002983Highly InformativeDirect
Biological processInhibition of host STAT2 by virus0.00003232Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentVirion0Moderately InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentHost nucleus0InformativeDirect
Cellular componentCapsid protein0InformativeDirect
Cellular componentHost cytoplasm0InformativeDirect
Cellular componentHost membrane0InformativeDirect
Cellular componentPeriplasm0.000004851InformativeDirect
Cellular componentHost endoplasmic reticulum0Highly InformativeDirect
Cellular componentHost cytoplasmic vesicle0Highly InformativeDirect
Cellular componentViral envelope protein0.0006531Highly InformativeDirect
Coding sequence diversityRibosomal frameshifting0Moderately InformativeDirect
Coding sequence diversityAlternative promoter usage0.0008766Moderately InformativeDirect
DiseaseOncogene0Moderately InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainSH3-binding0InformativeDirect
DomainEGF-like domain0InformativeDirect
DomainSignal-anchor0.000001437InformativeDirect
DomainKringle0Highly InformativeDirect
DomainSushi0Highly InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationNucleotidyltransferase0Moderately InformativeDirect
Post-translational modificationRNA-binding0.000002986Moderately InformativeDirect
Post-translational modificationNuclease1Moderately InformativeInherited
Post-translational modificationToxin0InformativeDirect
Post-translational modificationSerine protease0InformativeDirect
Post-translational modificationHelicase0InformativeDirect
Post-translational modificationIon channel0InformativeDirect
Post-translational modificationExonuclease0.000000000000923InformativeDirect
Post-translational modificationAntimicrobial0.00000005074InformativeDirect
Post-translational modificationMethyltransferase0.000003629InformativeDirect
Post-translational modificationThiol protease0.00008283InformativeDirect
Post-translational modificationHeparin-binding0.0001207InformativeDirect
Post-translational modificationRNA-directed RNA polymerase0Highly InformativeDirect
Post-translational modificationHemostasis impairing toxin0Highly InformativeDirect
Post-translational modificationViral nucleoprotein0Highly InformativeDirect
Post-translational modificationViral ion channel0Highly InformativeDirect
Post-translational modificationAntibiotic0.0000000000004672Highly InformativeDirect
Post-translational modificationGrowth factor binding0.0000000001625Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationCleavage on pair of basic residues0Moderately InformativeDirect
Post-translational modificationHydroxylation0InformativeDirect
Post-translational modificationZymogen0InformativeDirect
Post-translational modificationMyristate0.0000000002454InformativeDirect
Post-translational modificationSulfation0.000004992InformativeDirect
Post-translational modificationGamma-carboxyglutamic acid0Highly InformativeDirect
Post-translational modificationCovalent protein-RNA linkage0Highly InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR009003 SSF50494 Protein matches
Abstract

This signature recognises a large group of serine and cysteine peptidases (including prokaryotic, eukaryotic and viral), which share a common closed beta barrel structure.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 103 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Trypsin-like serine proteases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 103 hidden Markov models representing the Trypsin-like serine proteases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]