SUPERFAMILY 1.75 HMM library and genome assignments server


Trypsin-like serine proteases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Trypsin-like serine proteases [ 50493]
Superfamily:   Trypsin-like serine proteases [ 50494] (4)
Families:   Prokaryotic proteases [ 50495] (15)
  Eukaryotic proteases [ 50514] (47)
  Viral proteases [ 50596] (4)
  Viral cysteine protease of trypsin fold [ 50603] (3)


Superfamily statistics
Genomes (2,368) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 29,747 80,880 291
Proteins 28,125 78,015 291


Functional annotation
General category Processes_IC
Detailed category Proteases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)protein metabolic process00Least InformativeDirect
Biological Process (BP)response to stimulus10.765Least InformativeInherited
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)single-organism metabolic process11Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis11Least InformativeInherited
Biological Process (BP)multicellular organismal process0.0021830.4446Least InformativeInherited
Biological Process (BP)multi-organism process0.32696.138e-08Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.046810.0001451Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.050161Moderately InformativeInherited
Biological Process (BP)regulation of response to stimulus0.01447.303e-06Moderately InformativeInherited
Biological Process (BP)regulation of cell communication0.41571Moderately InformativeInherited
Biological Process (BP)regulation of signaling0.40321Moderately InformativeInherited
Biological Process (BP)gene expression11Moderately InformativeInherited
Biological Process (BP)system process0.12750.08502Moderately InformativeInherited
Biological Process (BP)immune system process0.0067410.004919Moderately InformativeInherited
Biological Process (BP)proteolysis00InformativeDirect
Biological Process (BP)defense response0.00084935.89e-06InformativeDirect
Biological Process (BP)response to wounding2.391e-066.635e-14InformativeDirect
Biological Process (BP)cellular component disassembly1.044e-082.076e-15InformativeDirect
Biological Process (BP)regulation of response to external stimulus0.00068034.008e-15InformativeDirect
Biological Process (BP)regulation of response to stress0.05657.814e-06InformativeInherited
Biological Process (BP)response to other organism0.83751InformativeInherited
Biological Process (BP)positive regulation of signal transduction0.24410.3174InformativeInherited
Biological Process (BP)blood circulation10.0007328InformativeInherited
Biological Process (BP)single-organism behavior0.5831InformativeInherited
Biological Process (BP)immune effector process0.22270.0006228InformativeInherited
Biological Process (BP)positive regulation of immune system process0.57110.002472InformativeInherited
Biological Process (BP)immune response0.0016296.537e-08InformativeInherited
Biological Process (BP)regulation of immune response0.90010.08091InformativeInherited
Biological Process (BP)regulation of blood pressure1.998e-080.0003224Highly InformativeDirect
Biological Process (BP)protein processing1.203e-110Highly InformativeDirect
Biological Process (BP)regulation of blood coagulation0.00089840Highly InformativeDirect
Biological Process (BP)extracellular matrix organization1.282e-084.571e-12Highly InformativeDirect
Biological Process (BP)multicellular organismal metabolic process2.433e-091.009e-05Highly InformativeDirect
Biological Process (BP)defense response to Gram-positive bacterium0.00058685.09e-08Highly InformativeDirect
Biological Process (BP)regulation of G-protein coupled receptor protein signaling pathway0.001880.01667Highly InformativeInherited
Biological Process (BP)learning or memory0.020490.01414Highly InformativeInherited
Biological Process (BP)activation of immune response0.8750.0001608Highly InformativeInherited
Biological Process (BP)humoral immune response0.96925.737e-06Highly InformativeInherited
Biological Process (BP)innate immune response0.71030.0001204Highly InformativeInherited
Biological Process (BP)protein activation cascade0.042890Highly InformativeInherited
Biological Process (BP)inflammatory response0.027250.7518Highly InformativeInherited
Biological Process (BP)leukocyte mediated immunity0.69690.9151Highly InformativeInherited
Molecular Function (MF)hydrolase activity00Least InformativeDirect
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)anion binding0.9751Moderately InformativeInherited
Molecular Function (MF)peptidase activity00InformativeDirect
Molecular Function (MF)endopeptidase activity5.926e-080Highly InformativeDirect
Molecular Function (MF)serine-type peptidase activity00Highly InformativeDirect
Molecular Function (MF)glycosaminoglycan binding1.916e-050.001472Highly InformativeInherited
Molecular Function (MF)sulfur compound binding4.06e-050.006855Highly InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)extracellular region00Moderately InformativeDirect
Cellular Component (CC)vesicle0.1810.07727Moderately InformativeInherited
Cellular Component (CC)extracellular space01.415e-11InformativeDirect
Cellular Component (CC)secretory granule2.867e-051.27e-10InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.765 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.4446 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) regulation of response to stimulus 7.303e-06 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.0001451 Moderately Informative Direct
Biological Process (BP) multi-organism process 6.138e-08 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.5152 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) system process 0.08502 Moderately Informative Inherited
Biological Process (BP) reproduction 0.6553 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.004919 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) immune effector process 0.0006228 Informative Direct
Biological Process (BP) proteolysis 0 Informative Direct
Biological Process (BP) defense response 5.89e-06 Informative Direct
Biological Process (BP) immune response 6.537e-08 Informative Direct
Biological Process (BP) blood circulation 0.0007328 Informative Direct
Biological Process (BP) response to wounding 6.635e-14 Informative Direct
Biological Process (BP) cellular component disassembly 2.076e-15 Informative Direct
Biological Process (BP) regulation of response to external stimulus 4.008e-15 Informative Direct
Biological Process (BP) secretion 0.0001767 Informative Direct
Biological Process (BP) regulation of body fluid levels 1.679e-13 Informative Direct
Biological Process (BP) regulation of response to stress 7.814e-06 Informative Direct
Biological Process (BP) positive regulation of nitrogen compound metabolic process 1 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.342 Informative Inherited
Biological Process (BP) response to external stimulus 1 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) apoptotic process 0.01352 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.5055 Informative Inherited
Biological Process (BP) sensory organ development 0.6322 Informative Inherited
Biological Process (BP) metal ion transport 0.122 Informative Inherited
Biological Process (BP) transmembrane transport 0.1647 Informative Inherited
Biological Process (BP) response to other organism 1 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.1258 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.002472 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 1 Informative Inherited
Biological Process (BP) regulation of reproductive process 0.005667 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.3174 Informative Inherited
Biological Process (BP) embryonic organ development 0.03338 Informative Inherited
Biological Process (BP) organ morphogenesis 0.8578 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.9576 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 1 Informative Inherited
Biological Process (BP) positive regulation of protein metabolic process 0.06976 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.08109 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.00486 Informative Inherited
Biological Process (BP) regulation of cell development 0.5413 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.03892 Informative Inherited
Biological Process (BP) single-organism behavior 1 Informative Inherited
Biological Process (BP) single organism reproductive process 0.1645 Informative Inherited
Biological Process (BP) multi-organism reproductive process 0.03429 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.3748 Informative Inherited
Biological Process (BP) sexual reproduction 0.3151 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.975 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 1 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 1 Informative Inherited
Biological Process (BP) positive regulation of phosphorus metabolic process 0.4943 Informative Inherited
Biological Process (BP) regulation of immune response 0.08091 Informative Inherited
Biological Process (BP) protein catabolic process 1 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 0.5381 Informative Inherited
Biological Process (BP) regulation of growth 0.007892 Informative Inherited
Biological Process (BP) activation of immune response 0.0001608 Highly Informative Direct
Biological Process (BP) exocytosis 1.07e-11 Highly Informative Direct
Biological Process (BP) humoral immune response 5.737e-06 Highly Informative Direct
Biological Process (BP) hemostasis 0 Highly Informative Direct
Biological Process (BP) regulation of blood pressure 0.0003224 Highly Informative Direct
Biological Process (BP) fertilization 2.124e-07 Highly Informative Direct
Biological Process (BP) regulation of cellular ketone metabolic process 1.478e-06 Highly Informative Direct
Biological Process (BP) negative regulation of cell development 3.508e-09 Highly Informative Direct
Biological Process (BP) monovalent inorganic cation transport 8.056e-05 Highly Informative Direct
Biological Process (BP) protein processing 0 Highly Informative Direct
Biological Process (BP) regulation of blood coagulation 0 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 4.571e-12 Highly Informative Direct
Biological Process (BP) regulation of cellular amine metabolic process 3.909e-11 Highly Informative Direct
Biological Process (BP) modification of morphology or physiology of other organism 6.117e-14 Highly Informative Direct
Biological Process (BP) wound healing 3.475e-05 Highly Informative Direct
Biological Process (BP) regulation of multi-organism process 3.406e-05 Highly Informative Direct
Biological Process (BP) multicellular organismal metabolic process 1.009e-05 Highly Informative Direct
Biological Process (BP) multi-multicellular organism process 4.07e-08 Highly Informative Direct
Biological Process (BP) innate immune response 0.0001204 Highly Informative Direct
Biological Process (BP) positive regulation of epithelial cell proliferation 4.504e-05 Highly Informative Direct
Biological Process (BP) coagulation 0 Highly Informative Direct
Biological Process (BP) defense response to Gram-positive bacterium 5.09e-08 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 4.804e-05 Highly Informative Direct
Biological Process (BP) regulation of protein processing 0 Highly Informative Direct
Biological Process (BP) protein activation cascade 0 Highly Informative Direct
Biological Process (BP) apoptotic signaling pathway 0.0003438 Highly Informative Direct
Biological Process (BP) regulation of organ morphogenesis 1.601e-06 Highly Informative Direct
Biological Process (BP) inner ear development 0.001765 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 0.004005 Highly Informative Inherited
Biological Process (BP) ion transmembrane transport 0.002265 Highly Informative Inherited
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 0.001562 Highly Informative Inherited
Biological Process (BP) sensory perception 0.1114 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 0.07453 Highly Informative Inherited
Biological Process (BP) regulation of G-protein coupled receptor protein signaling pathway 0.01667 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.001757 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.001268 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis 0.006919 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.9499 Highly Informative Inherited
Biological Process (BP) adult behavior 0.07267 Highly Informative Inherited
Biological Process (BP) learning or memory 0.01414 Highly Informative Inherited
Biological Process (BP) regulation of inflammatory response 0.9352 Highly Informative Inherited
Biological Process (BP) inflammatory response 0.7518 Highly Informative Inherited
Biological Process (BP) leukocyte mediated immunity 0.9151 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) peptidase activity 0 Informative Direct
Molecular Function (MF) inorganic cation transmembrane transporter activity 0.1123 Informative Inherited
Molecular Function (MF) metal ion transmembrane transporter activity 0.0551 Informative Inherited
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 0.004189 Informative Inherited
Molecular Function (MF) endopeptidase activity 0 Highly Informative Direct
Molecular Function (MF) serine-type peptidase activity 0 Highly Informative Direct
Molecular Function (MF) monosaccharide binding 1.525e-05 Highly Informative Direct
Molecular Function (MF) channel regulator activity 0.01714 Highly Informative Inherited
Molecular Function (MF) ion gated channel activity 0.01364 Highly Informative Inherited
Molecular Function (MF) glycosaminoglycan binding 0.001472 Highly Informative Inherited
Molecular Function (MF) sulfur compound binding 0.006855 Highly Informative Inherited
Molecular Function (MF) ion channel activity 0.08077 Highly Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) extracellular region 0 Moderately Informative Direct
Cellular Component (CC) endoplasmic reticulum 0.06212 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 0.8966 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 1 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 0.679 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) vesicle 0.07727 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) extracellular space 1.415e-11 Informative Direct
Cellular Component (CC) secretory granule 1.27e-10 Informative Direct
Cellular Component (CC) vacuole 0.7115 Informative Inherited
Cellular Component (CC) nuclear envelope 0.004524 Informative Inherited
Cellular Component (CC) external encapsulating structure 0.009705 Informative Inherited
Cellular Component (CC) Golgi apparatus 1 Informative Inherited
Cellular Component (CC) cell envelope 3.994e-08 Highly Informative Direct
Cellular Component (CC) nuclear membrane 1.182e-07 Highly Informative Direct
Cellular Component (CC) periplasmic space 4.838e-12 Highly Informative Direct
Cellular Component (CC) external encapsulating structure part 2.67e-09 Highly Informative Direct
Cellular Component (CC) acrosomal vesicle 0.0765 Highly Informative Inherited
Cellular Component (CC) cytoplasmic vesicle part 0.02818 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Nucleotidyltransferases0Least InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.2689Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Least InformativeInherited
Enzyme Commission (EC)In phosphorous-containing anhydrides0Moderately InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0Moderately InformativeDirect
Enzyme Commission (EC)Cysteine endopeptidases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an1.469e-09Moderately InformativeDirect
Enzyme Commission (EC)Omega peptidases1Moderately InformativeInherited
Enzyme Commission (EC)Methyltransferases0.3112Moderately InformativeInherited
Enzyme Commission (EC)mRNA (nucleoside-2'-O-)-methyltransferase0InformativeDirect
Enzyme Commission (EC)RNA-directed RNA polymerase0InformativeDirect
Enzyme Commission (EC)mRNA (guanine-N(7)-)-methyltransferase0InformativeDirect
Enzyme Commission (EC)Nucleoside-triphosphatase0InformativeDirect
Enzyme Commission (EC)Flavivirin1.561e-12InformativeDirect
Enzyme Commission (EC)SARS coronavirus main proteinase4.76e-08InformativeDirect
Enzyme Commission (EC)Picornain 3C1.101e-14Highly InformativeDirect
Enzyme Commission (EC)Hepacivirin4.68e-10Highly InformativeDirect
Enzyme Commission (EC)Togavirin8.498e-09Highly InformativeDirect
Enzyme Commission (EC)Picornain 2A1.621e-08Highly InformativeDirect
Enzyme Commission (EC)Nuclear-inclusion-a endopeptidase4.76e-08Highly InformativeDirect
Enzyme Commission (EC)Coagulation factor Xa8.542e-07Highly InformativeDirect
Enzyme Commission (EC)Calicivirin2.318e-05Highly InformativeDirect
Enzyme Commission (EC)Helper-component proteinase5.07e-05Highly InformativeDirect
Enzyme Commission (EC)Coagulation factor IXa8.367e-05Highly InformativeDirect
Enzyme Commission (EC)Plasmin0.0001015Highly InformativeDirect
Enzyme Commission (EC)Protein C (activated)0.0001485Highly InformativeDirect
Enzyme Commission (EC)T-plasminogen activator0.0002633Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)skin disease0.009837Moderately InformativeInherited
Disease Ontology (DO)vascular disease0.08679Moderately InformativeInherited
Disease Ontology (DO)heart disease0.08996Moderately InformativeInherited
Disease Ontology (DO)myocardial infarction0.0001467InformativeDirect
Disease Ontology (DO)vascular skin disease0.08082InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
ONset and clinical course (ON)Variable expressivity0.0008045Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of head and neck0.9Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.9044Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.9981Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.01294Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.6498Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genital system0.7617Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal bleeding0.02803InformativeInherited
Phenotypic Abnormality (PA)Puberty and gonadal disorders0.09924InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system physiology0.4921InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the nose0.542InformativeInherited
Phenotypic Abnormality (PA)Joint hemorrhage5.971e-06Highly InformativeDirect
Phenotypic Abnormality (PA)Menorrhagia4.346e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Epistaxis4.346e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Deep venous thrombosis4.615e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of coagulation0.001032Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.01131Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.1364Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.9368Least InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to infection0.001133Moderately InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.3292Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.6292Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.7961Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.9333Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood coagulation1.629e-06InformativeDirect
Mammalian Phenotype (MP)increased susceptibility to infection0.0002416InformativeDirect
Mammalian Phenotype (MP)abnormal uvea morphology0.01819InformativeInherited
Mammalian Phenotype (MP)pathological neovascularization0.037InformativeInherited
Mammalian Phenotype (MP)decreased susceptibility to induced choroidal neovascularization9.943e-05Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)pericellular component development variant3.341e-06Moderately InformativeDirect
Worm Phenotype (WP)basement membrane remodeling variant1.136e-06InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)alimentary system0.00198Least InformativeInherited
Xenopus ANatomical entity (XAN)viscus0.1448Least InformativeInherited
Xenopus ANatomical entity (XAN)pancreas0.0004335Highly InformativeDirect
Xenopus DEvelopment stage (XDE)tadpole1.073e-06InformativeDirect
Xenopus DEvelopment stage (XDE)NF stage 556.87e-05Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)shoot apex0Least InformativeDirect
Plant ANatomical entity (PAN)vascular leaf0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.256Moderately InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Moderately InformativeInherited
Enzyme Commission (EC)RNA-directed RNA polymerase0InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0InformativeDirect
Enzyme Commission (EC)Cysteine endopeptidases0InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides0InformativeDirect
Enzyme Commission (EC)RNA helicase0InformativeDirect
Enzyme Commission (EC)Omega peptidases1InformativeInherited
Enzyme Commission (EC)mRNA (guanine-N(7)-)-methyltransferase0Highly InformativeDirect
Enzyme Commission (EC)mRNA (nucleoside-2'-O)-methyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Nucleoside-triphosphate phosphatase0Highly InformativeDirect
Enzyme Commission (EC)Picornain 3C8.852e-15Highly InformativeDirect
Enzyme Commission (EC)Flavivirin1.419e-12Highly InformativeDirect
Enzyme Commission (EC)Picornain 2A1.432e-08Highly InformativeDirect
Enzyme Commission (EC)SARS coronavirus main proteinase4.256e-08Highly InformativeDirect

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)blood and blood forming organs1.506e-06Least InformativeDirect
Drugbank ATC_code (DB)antihemorrhagics1.774e-06InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processApoptosis0Moderately InformativeDirect
Biological processIon transport0Moderately InformativeDirect
Biological processHost-virus interaction0Moderately InformativeDirect
Biological processViral RNA replication0InformativeDirect
Biological processViral immunoevasion0InformativeDirect
Biological processVirus entry into host cell0InformativeDirect
Biological processViral attachment to host cell0InformativeDirect
Biological processUbl conjugation pathway1.514e-14InformativeDirect
Biological processCytolysis1.137e-10InformativeDirect
Biological processInnate immunity0.0004324InformativeDirect
Biological processAcute phase0Highly InformativeDirect
Biological processmRNA capping0Highly InformativeDirect
Biological processActivation of host autophagy by virus0Highly InformativeDirect
Biological processModulation of host ubiquitin pathway by viral deubiquitinase0Highly InformativeDirect
Biological processFusion of virus membrane with host endosomal membrane0Highly InformativeDirect
Biological processViral ion channel0Highly InformativeDirect
Biological processComplement pathway5.948e-12Highly InformativeDirect
Biological processModulation of host cell cycle by virus4.889e-09Highly InformativeDirect
Biological processInhibition of host ISG15 by virus5.598e-09Highly InformativeDirect
Biological processInhibition of host TYK2 by virus3.932e-08Highly InformativeDirect
Biological processComplement alternate pathway0.0002442Highly InformativeDirect
Biological processHost gene expression shutoff by virus1Highly InformativeInherited
Cellular componentMembrane0Least InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentVirion0InformativeDirect
Cellular componentHost cytoplasm0InformativeDirect
Cellular componentHost membrane0InformativeDirect
Cellular componentHost nucleus0InformativeDirect
Cellular componentPeriplasm2.39e-07InformativeDirect
Cellular componentHost cytoplasmic vesicle0Highly InformativeDirect
Cellular componentHost endoplasmic reticulum0Highly InformativeDirect
Cellular componentViral envelope protein0.000816Highly InformativeDirect
Coding sequence diversityRibosomal frameshifting0Moderately InformativeDirect
Coding sequence diversityAlternative promoter usage9.522e-05Moderately InformativeDirect
DiseaseOncogene0Moderately InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainSignal-anchor1.07e-06Moderately InformativeDirect
DomainEGF-like domain0InformativeDirect
DomainSH3-binding0InformativeDirect
DomainKringle0Highly InformativeDirect
DomainSushi0Highly InformativeDirect
Molecular functionMetal-binding1Least InformativeInherited
Molecular functionNucleotide-binding1Least InformativeInherited
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionRNA-binding2.715e-12Moderately InformativeDirect
Molecular functionZinc-finger0.0001005Moderately InformativeDirect
Molecular functionHelicase0InformativeDirect
Molecular functionGrowth factor binding3.577e-11Highly InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationNucleotidyltransferase0Moderately InformativeDirect
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationNuclease1Moderately InformativeInherited
Post-translational modificationCapsid protein0InformativeDirect
Post-translational modificationIon channel0InformativeDirect
Post-translational modificationSerine protease0InformativeDirect
Post-translational modificationToxin0InformativeDirect
Post-translational modificationExonuclease8.595e-13InformativeDirect
Post-translational modificationAntimicrobial2.114e-08InformativeDirect
Post-translational modificationThiol protease0.0001332InformativeDirect
Post-translational modificationRNA-directed RNA polymerase0Highly InformativeDirect
Post-translational modificationHemostasis impairing toxin0Highly InformativeDirect
Post-translational modificationAntibiotic7.172e-14Highly InformativeDirect
Post-translational modificationAntioxidant1.438e-09Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationCleavage on pair of basic residues0Moderately InformativeDirect
Post-translational modificationHydroxylation0InformativeDirect
Post-translational modificationZymogen0InformativeDirect
Post-translational modificationMyristate1.778e-08InformativeDirect
Post-translational modificationCovalent protein-RNA linkage0Highly InformativeDirect
Post-translational modificationGamma-carboxyglutamic acid0Highly InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR009003 SSF50494 Protein matches
Abstract

This signature recognises a large group of serine and cysteine peptidases (including prokaryotic, eukaryotic and viral), which share a common closed beta barrel structure.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 103 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Trypsin-like serine proteases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 103 hidden Markov models representing the Trypsin-like serine proteases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · Internal database links ]