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Trypsin-like serine proteases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Trypsin-like serine proteases [ 50493]
Superfamily:   Trypsin-like serine proteases [ 50494] (4)
Families:   Prokaryotic proteases [ 50495] (15)
  Eukaryotic proteases [ 50514] (47)
  Viral proteases [ 50596] (4)
  Viral cysteine protease of trypsin fold [ 50603] (3)


Superfamily statistics
Genomes (3,102) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 36,499 247,001 291
Proteins 34,150 234,619 291


Functional annotation
General category Processes_IC
Detailed category Proteases

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Nucleotidyltransferases0Least InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.2689Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Least InformativeInherited
Enzyme Commission (EC)In phosphorous-containing anhydrides0Moderately InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0Moderately InformativeDirect
Enzyme Commission (EC)Cysteine endopeptidases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an0.000000001469Moderately InformativeDirect
Enzyme Commission (EC)Omega peptidases1Moderately InformativeInherited
Enzyme Commission (EC)Methyltransferases0.3112Moderately InformativeInherited
Enzyme Commission (EC)mRNA (nucleoside-2'-O-)-methyltransferase0InformativeDirect
Enzyme Commission (EC)RNA-directed RNA polymerase0InformativeDirect
Enzyme Commission (EC)mRNA (guanine-N(7)-)-methyltransferase0InformativeDirect
Enzyme Commission (EC)Nucleoside-triphosphatase0InformativeDirect
Enzyme Commission (EC)Flavivirin0.000000000001561InformativeDirect
Enzyme Commission (EC)SARS coronavirus main proteinase0.0000000476InformativeDirect
Enzyme Commission (EC)Picornain 3C0.00000000000001101Highly InformativeDirect
Enzyme Commission (EC)Hepacivirin0.000000000468Highly InformativeDirect
Enzyme Commission (EC)Togavirin0.000000008498Highly InformativeDirect
Enzyme Commission (EC)Picornain 2A0.00000001621Highly InformativeDirect
Enzyme Commission (EC)Nuclear-inclusion-a endopeptidase0.0000000476Highly InformativeDirect
Enzyme Commission (EC)Coagulation factor Xa0.0000008542Highly InformativeDirect
Enzyme Commission (EC)Calicivirin0.00002318Highly InformativeDirect
Enzyme Commission (EC)Helper-component proteinase0.0000507Highly InformativeDirect
Enzyme Commission (EC)Coagulation factor IXa0.00008367Highly InformativeDirect
Enzyme Commission (EC)Plasmin0.0001015Highly InformativeDirect
Enzyme Commission (EC)Protein C (activated)0.0001485Highly InformativeDirect
Enzyme Commission (EC)T-plasminogen activator0.0002633Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)hematopoietic system disease0.000139Moderately InformativeDirect
Disease Ontology (DO)skin disease0.00697Moderately InformativeInherited
Disease Ontology (DO)inherited blood coagulation disease0.0009167InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.2371Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.8738Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the head0.9598Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature1Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology1Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.000002207Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.2613Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiovascular system physiology0.2621Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of immune system physiology0.4072Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.4933Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal reproductive system morphology0.749Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal oral cavity morphology1Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal skeletal muscle morphology1Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of complement system0.0002186InformativeDirect
Phenotypic Abnormality (PA)Abnormality of blood circulation0.007355InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the menstrual cycle0.07175InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the coagulation cascade0.163InformativeInherited
Phenotypic Abnormality (PA)Abnormal bleeding0.2542InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the dentition0.5534InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the nose0.7348InformativeInherited
Phenotypic Abnormality (PA)Joint hemorrhage0.000000007262Highly InformativeDirect
Phenotypic Abnormality (PA)Prolonged prothrombin time0.00001456Highly InformativeDirect
Phenotypic Abnormality (PA)Intramuscular hematoma0.00002483Highly InformativeDirect
Phenotypic Abnormality (PA)Epistaxis0.0004287Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the gingiva0.00219Highly InformativeInherited
Phenotypic Abnormality (PA)Hemolytic anemia1Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.0583Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.38Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.9928Least InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.3807Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.5128Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.7571Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.8437Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.9942Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood coagulation0.00004059InformativeDirect
Mammalian Phenotype (MP)abnormal uvea morphology0.01707InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel physiology0.4893InformativeInherited
Mammalian Phenotype (MP)abnormal humoral immune response0.9434InformativeInherited
Mammalian Phenotype (MP)decreased susceptibility to induced choroidal neovascularization0.0001016Highly InformativeDirect
Mammalian Phenotype (MP)abnormal complement pathway0.0004001Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)pericellular component development variant0.000000002746Moderately InformativeDirect
Worm Phenotype (WP)basement membrane remodeling variant0.0000000003888InformativeDirect

Document: WP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)trunk0.5356Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical system1Least InformativeInherited
Xenopus ANatomical entity (XAN)viscus0.03293Moderately InformativeInherited
Xenopus ANatomical entity (XAN)alimentary system0.04137Moderately InformativeInherited
Xenopus ANatomical entity (XAN)pancreas0.0001041Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.0000000000001078Moderately InformativeDirect
Enzyme Commission (EC)Transferring one-carbon groups0.6923Moderately InformativeInherited
Enzyme Commission (EC)RNA-directed RNA polymerase0InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0InformativeDirect
Enzyme Commission (EC)Cysteine endopeptidases0InformativeDirect
Enzyme Commission (EC)In phosphorus-containing anhydrides0InformativeDirect
Enzyme Commission (EC)RNA helicase0InformativeDirect
Enzyme Commission (EC)Omega peptidases1InformativeInherited
Enzyme Commission (EC)mRNA (guanine-N(7)-)-methyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Methyltransferase cap10Highly InformativeDirect
Enzyme Commission (EC)Flavivirin0Highly InformativeDirect
Enzyme Commission (EC)Nucleoside-triphosphate phosphatase0Highly InformativeDirect
Enzyme Commission (EC)Picornain 3C0.00000000000001478Highly InformativeDirect
Enzyme Commission (EC)SARS coronavirus main proteinase0.0000002825Highly InformativeDirect

Document: EC annotation of SCOP domains

InterPro annotation
Cross references IPR009003 SSF50494 Protein matches
Abstract

This signature recognises a large group of serine and cysteine peptidases (including prokaryotic, eukaryotic and viral), which share a common closed beta barrel structure.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 181 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Trypsin-like serine proteases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 181 hidden Markov models representing the Trypsin-like serine proteases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]